Fig. 1Ten-year probabilities of atherosclerotic cardiovascular disease (ASCVD) in men from the Korean Genome and Epidemiology Study (KOGES)-Ansan and Ansung study. (A) The Pooled Cohort Equations for non-Hispanic whites. (B) The Pooled Cohort Equations for African Americans. (C) The Framingham Global Cardiovascular Risk Score. (D) The Korean Risk Prediction Model.
Fig. 2Ten-year probabilities of atherosclerotic cardiovascular disease (ASCVD) in women from the Korean Genome and Epidemiology Study (KOGES)-Ansan and Ansung study. (A) The Pooled Cohort Equations for non-Hispanic whites. (B) The Pooled Cohort Equations for African Americans. (C) The Framingham Global Cardiovascular Risk Score. (D) The Korean Risk Prediction Model.
Fig. 3Ten-year probabilities of atherosclerotic cardiovascular disease (ASCVD) in men and women from the Korean Genome and Epidemiology Study (KOGES)-Ansan and Ansung study using the recalibrated and new Pooled Cohort Equations. (A) The recalibrated Pooled Cohort Equations for non-Hispanic whites in men. (B) The recalibrated Pooled Cohort Equations for African Americans in men. (C) The recalibrated Pooled Cohort Equations for non-Hispanic whites in women. (D) The recalibrated Pooled Cohort Equations for African Americans in women. (E) The new Pooled Cohort Equations in men. (F) The new Pooled Cohort Equations in women.
Table 1Baseline characteristics of the study participants
Characteristic |
KOGES |
PCE-WHa
|
PCE-AAa
|
FRS-CVD |
KRPM |
P value |
Men |
3,778 |
9,098 |
1,647 |
3,969 |
119,715 |
|
Age, yr |
51.3±8.6 |
56.2±6.5 |
55.4±5.6 |
48.5±10.8 |
50.1±7.9 |
<0.001 |
Total cholesterol, mg/dL |
192±36 |
211±38 |
208±43 |
213±39 |
197±35 |
<0.001 |
HDL-C, mg/dL |
44±10 |
44±12 |
51±17 |
45±12 |
48±11 |
<0.001 |
Systolic BP, mm Hg |
125±17 |
124±16 |
129±20 |
130±18 |
125±18 |
<0.001 |
BP treatment, % |
8.5 |
16.9 |
31.2 |
10.1 |
NA |
<0.001b
|
Diabetes mellitus, % |
7.8 |
8.8 |
15.9 |
6.5 |
10.5 |
<0.001 |
Current smoker, % |
48.1 |
25.5 |
35.5 |
35.2 |
49.4 |
<0.001 |
Women |
4,154 |
11,240 |
2,641 |
4,522 |
80,295 |
|
Age, yr |
52.4±9.0 |
56.8±6.5 |
55.3±5.4 |
49.1±11.1 |
51.8±8.1 |
<0.001 |
Total cholesterol, mg/dL |
191±35 |
221±41 |
214±44 |
215±44 |
201±37 |
<0.001 |
HDL-C, mg/dL |
46±10 |
58±16 |
59±17 |
58±15 |
54±13 |
<0.001 |
Systolic BP, mm Hg |
124±20 |
121±18 |
127±20 |
126±20 |
125±20 |
<0.001 |
BP treatment, % |
13.1 |
18.5 |
40.8 |
11.8 |
NA |
<0.001b
|
Diabetes mellitus, % |
6.0 |
6.3 |
17.4 |
3.8 |
7.4 |
<0.001 |
Current smoker, % |
3.4 |
24.9 |
22.7 |
34.2 |
4.5 |
<0.001 |
Table 2Predicted and observed risks of atherosclerotic cardiovascular disease among participants from the KOGES-Ansan and Ansung study
Variable |
Predicted risk, % |
Observed risk, % (n) |
Absolute difference |
Discordance, %a
|
C-statistic |
Calibration |
χ2 statistic |
P value |
Men (n=3,778) |
|
|
|
|
|
|
|
PCE-WH |
8.51 |
8.05 (305) |
0.46 |
6 |
0.731 |
10.59 |
0.226 |
PCE-AA |
9.13 |
8.05 (305) |
1.08 |
13 |
0.730 |
17.13 |
0.029 |
FRS-CVD |
15.34 |
8.05 (305) |
7.29 |
91 |
0.730 |
177.71 |
<0.001 |
KRPM |
5.55 |
8.05 (305) |
-2.50 |
-31 |
0.735 |
58.39 |
<0.001 |
Women (n=4,154) |
|
|
|
|
|
|
|
PCE-WH |
3.58 |
7.05 (293) |
-3.47 |
-49 |
0.726 |
258.62 |
<0.001 |
PCE-AA |
5.29 |
7.05 (293) |
-1.76 |
-25 |
0.732 |
107.08 |
<0.001 |
FRS-CVD |
7.23 |
7.05 (293) |
0.18 |
3 |
0.726 |
24.70 |
0.002 |
KRPM |
4.85 |
7.05 (293) |
-2.20 |
-31 |
0.729 |
67.27 |
<0.001 |