Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
23 "Adipose tissue"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Metabolic Risk/Epidemiology
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
Tong Bu, Ziyan Sun, Yi Pan, Xia Deng, Guoyue Yuan
Received August 14, 2023  Accepted January 1, 2024  Published online April 1, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0277    [Epub ahead of print]
  • 241 View
  • 9 Download
AbstractAbstract PDFPubReader   ePub   
Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.
Original Article
Lifestyle
Associations of Ultra-Processed Food Intake with Body Fat and Skeletal Muscle Mass by Sociodemographic Factors
Sukyoung Jung, Jaehee Seo, Jee Young Kim, Sohyun Park
Received September 19, 2023  Accepted November 7, 2023  Published online February 2, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0335    [Epub ahead of print]
  • 1,138 View
  • 72 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The effects of excessive ultra-processed food (UPF) consumption on body composition measures or sociodemographic disparities are understudied in Korea. We aimed to investigate the association of UPF intake with percent body fat (PBF) and percent appendicular skeletal muscle mass (PASM) by sociodemographic status in adults.
Methods
This study used data from the Korea National Health and Nutrition Examination Survey 2008–2011 (n=11,123 aged ≥40 years). We used a NOVA system to classify all foods reported in a 24-hour dietary recall, and the percentage of energy intake (%kcal) from UPFs was estimated. PBF and PASM were measured by dual-energy X-ray absorptiometry. Tertile (T) 3 of PBF indicated adiposity and T1 of PASM indicated low skeletal muscle mass, respectively. Multinomial logistic regression models were used to estimate odds ratios (OR) with 95% confidence interval (CI) after adjusting covariates.
Results
UPF intake was positively associated with PBF-defined adiposity (ORper 10% increase, 1.04; 95% CI, 1.002 to 1.08) and low PASM (ORper 10% increase, 1.05; 95% CI, 1.01 to 1.09). These associations were stronger in rural residents (PBF: ORper 10% increase, 1.14; 95% CI, 1.06 to 1.23; PASM: ORper 10% increase, 1.15; 95% CI, 1.07 to 1.23) and not college graduates (PBF: ORper 10% increase, 1.06; 95% CI, 1.02 to 1.11; PASM: ORper 10% increase, 1.07; 95% CI, 1.03 to 1.12) than their counterparts.
Conclusion
A higher UPF intake was associated with higher adiposity and lower skeletal muscle mass among Korean adults aged 40 years and older, particularly in those from rural areas and with lower education levels.
Reviews
Pathophysiology
Epicardial Adipose Tissue and Heart Failure, Friend or Foe?
Dong-Hyuk Cho, Seong-Mi Park
Received June 20, 2023  Accepted December 11, 2023  Published online February 2, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0190    [Epub ahead of print]
  • 764 View
  • 70 Download
  • 1 Crossref
AbstractAbstract PDFPubReader   ePub   
Heart failure (HF) management guidelines recommend individualized assessments based on HF phenotypes. Adiposity is a known risk factor for HF. Recently, there has been an increased interest in organ-specific adiposity, specifically the role of the epicardial adipose tissue (EAT), in HF risk. EAT is easily assessable through various imaging modalities and is anatomically and functionally connected to the myocardium. In pathological conditions, EAT secretes inflammatory cytokines, releases excessive fatty acids, and increases mechanical load on the myocardium, resulting in myocardial remodeling. EAT plays a pathophysiological role in characterizing both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). In HFrEF, EAT volume is reduced, reflecting an impaired metabolic reservoir, whereas in HFpEF, the amount of EAT is associated with worse biomarker and hemodynamic profiles, indicating increased EAT activity. Studies have examined the possibility of therapeutically targeting EAT, and recent studies using sodium glucose cotransporter 2 inhibitors have shown potential in reducing EAT volume. However, further research is required to determine the clinical implications of reducing EAT activity in patients with HF.

Citations

Citations to this article as recorded by  
  • New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review
    Jorge E. Jalil, Luigi Gabrielli, María Paz Ocaranza, Paul MacNab, Rodrigo Fernández, Bruno Grassi, Paulina Jofré, Hugo Verdejo, Monica Acevedo, Samuel Cordova, Luis Sanhueza, Douglas Greig
    International Journal of Molecular Sciences.2024; 25(8): 4407.     CrossRef
Basic Research
Adipose Tissue and Metabolic Health
Sung-Min An, Seung-Hee Cho, John C. Yoon
Diabetes Metab J. 2023;47(5):595-611.   Published online July 24, 2023
DOI: https://doi.org/10.4093/dmj.2023.0011
  • 3,702 View
  • 430 Download
  • 2 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   ePub   
In this review, we provide a brief synopsis of the connections between adipose tissue and metabolic health and highlight some recent developments in understanding and exploiting adipocyte biology. Adipose tissue plays critical roles in the regulation of systemic glucose and lipid metabolism and secretes bioactive molecules possessing endocrine, paracrine, and autocrine functions. Dysfunctional adipose tissue has a detrimental impact on metabolic health and is intimately involved in key aspects of metabolic diseases such as insulin resistance, lipid overload, inflammation, and organelle stress. Differences in the distribution of fat depots and adipose characteristics relate to divergent degrees of metabolic dysfunction found in metabolically healthy and unhealthy obese individuals. Thermogenic adipocytes increase energy expenditure via mitochondrial uncoupling or adenosine triphosphate-consuming futile substrate cycles, while functioning as a metabolic sink and participating in crosstalk with other metabolic organs. Manipulation of adipose tissue provides a wealth of opportunities to intervene and combat the progression of associated metabolic diseases. We discuss current treatment modalities for obesity including incretin hormone analogs and touch upon emerging strategies with therapeutic potential including exosome-based therapy, pharmacological activation of brown and beige adipocyte thermogenesis, and administration or inhibition of adipocyte-derived factors.

Citations

Citations to this article as recorded by  
  • Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads
    Srinivasa Reddy Bonam, Dylan Mastrippolito, Philippe Georgel, Sylviane Muller
    Trends in Pharmacological Sciences.2024; 45(1): 81.     CrossRef
  • Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts
    Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
    Biomolecular Concepts.2024;[Epub]     CrossRef
  • Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes
    Sneha Dhokte, Krzysztof Czaja
    Nutrients.2024; 16(7): 1015.     CrossRef
  • Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity
    Cristina Elena Negroiu, Iulia Tudorașcu, Cristina Maria Bezna, Sanziana Godeanu, Marina Diaconu, Raluca Danoiu, Suzana Danoiu
    Journal of Clinical Medicine.2024; 13(7): 1973.     CrossRef
Original Article
Metabolic Risk/Epidemiology
Association of Myosteatosis with Nonalcoholic Fatty Liver Disease, Severity, and Liver Fibrosis Using Visual Muscular Quality Map in Computed Tomography
Hwi Seung Kim, Jiwoo Lee, Eun Hee Kim, Min Jung Lee, In Young Bae, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim, Chang Hee Jung
Diabetes Metab J. 2023;47(1):104-117.   Published online January 26, 2023
DOI: https://doi.org/10.4093/dmj.2022.0081
  • 3,182 View
  • 175 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The association of myosteatosis measured using visual muscular quality map in computed tomography (CT) with nonalcoholic fatty liver disease (NAFLD), its severity, and fibrosis was analyzed in a large population.
Methods
Subjects (n=13,452) with abdominal CT between 2012 and 2013 were measured total abdominal muscle area (TAMA) at L3 level. TAMA was segmented into intramuscular adipose tissue and skeletal muscle area (SMA), which was further classified into normal attenuation muscle area (NAMA) and low attenuation muscle area (LAMA). The following variables were adopted as indicators of myosteatosis: SMA/body mass index (BMI), NAMA/BMI, NAMA/TAMA, and LAMA/BMI. NAFLD and its severity were assessed by ultrasonography, and liver fibrosis was measured by calculating the NAFLD fibrosis score (NFS) and fibrosis-4 index (FIB-4) scores.
Results
According to multiple logistic regression analyses, as quartiles of SMA/BMI, NAMA/BMI, and NAMA/TAMA increased, the odds ratios (ORs) for NAFLD decreased in each sex (P for trend <0.001 for all). The ORs of moderate/severe NAFLD were significantly higher in the Q1 group than in the Q4 group for SMA/BMI, NAMA/BMI, and NAMA/TAMA in men. The ORs of intermediate/high liver fibrosis scores assessed by NFS and FIB-4 scores increased linearly with decreasing quartiles for SMA/BMI, NAMA/BMI, and NAMA/TAMA in each sex (P for trend <0.001 for all). Conversely, the risk for NAFLD and fibrosis were positively associated with LAMA/BMI quartiles in each sex (P for trend <0.001 for all).
Conclusion
A higher proportion of good quality muscle was associated with lower risks of NAFLD and fibrosis.

Citations

Citations to this article as recorded by  
  • Association of Myosteatosis with Nonalcoholic Fatty Liver Disease, Severity, and Liver Fibrosis Using Visual Muscular Quality Map in Computed Tomography (Diabetes Metab J 2023;47:104-17)
    Hwi Seung Kim, Hong-Kyu Kim, Chang Hee Jung
    Diabetes & Metabolism Journal.2023; 47(2): 304.     CrossRef
  • Association of Myosteatosis with Nonalcoholic Fatty Liver Disease, Severity, and Liver Fibrosis Using Visual Muscular Quality Map in Computed Tomography (Diabetes Metab J 2023;47:104-17)
    Eun Roh
    Diabetes & Metabolism Journal.2023; 47(2): 301.     CrossRef
  • Sarcopenia, a condition shared by various diseases: can we alleviate or delay the progression?
    Giovanni Tarantino, Gaia Sinatti, Vincenzo Citro, Silvano Santini, Clara Balsano
    Internal and Emergency Medicine.2023; 18(7): 1887.     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Current view of the surgical anatomy of the anterolateral abdominal wall muscles and their aponeuroses
    A.V. Pavlov, A.S. Baranova, A.V. Fedoseyev, A.I. Vvedensky, G.S. Lazutina, N.V. Ovchinnikova, I.V. Bakharev
    Operativnaya khirurgiya i klinicheskaya anatomiya (Pirogovskii nauchnyi zhurnal).2023; 7(3): 44.     CrossRef
  • Muscle Fat Content Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Chinese Adults
    W. Guo, X. Zhao, D. Cheng, X. Liang, M. Miao, X. Li, J. Lu, N. Xu, Shuang Hu, Qun Zhang
    The Journal of nutrition, health and aging.2023; 27(11): 960.     CrossRef
Reviews
Basic Research
Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation
Eun Ju Bae, Byung-Hyun Park
Diabetes Metab J. 2023;47(2):164-172.   Published online January 12, 2023
DOI: https://doi.org/10.4093/dmj.2022.0270
  • 3,682 View
  • 229 Download
  • 4 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Adipose tissue (AT) inflammation is strongly associated with obesity-induced insulin resistance. When subjected to metabolic stress, adipocytes become inflamed and secrete a plethora of cytokines and chemokines, which recruit circulating immune cells to AT. Although sirtuin 6 (Sirt6) is known to control genomic stabilization, aging, and cellular metabolism, it is now understood to also play a pivotal role in the regulation of AT inflammation. Sirt6 protein levels are reduced in the AT of obese humans and animals and increased by weight loss. In this review, we summarize the potential mechanism of AT inflammation caused by impaired action of Sirt6 from the immune cells’ point of view. We first describe the properties and functions of immune cells in obese AT, with an emphasis on discrete macrophage subpopulations which are central to AT inflammation. We then highlight data that links Sirt6 to functional phenotypes of AT inflammation. Importantly, we discuss in detail the effects of Sirt6 deficiency in adipocytes, macrophages, and eosinophils on insulin resistance or AT browning. In our closing perspectives, we discuss emerging issues in this field that require further investigation.

Citations

Citations to this article as recorded by  
  • The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms
    Adrianna Dzidek, Olga Czerwińska-Ledwig, Małgorzata Żychowska, Wanda Pilch, Anna Piotrowska
    International Journal of Molecular Sciences.2023; 24(11): 9655.     CrossRef
  • Exploring the Influence of Age, Gender and Body Mass Index on Colorectal Cancer Location
    Dorel Popovici, Cristian Stanisav, Sorin Saftescu, Serban Negru, Radu Dragomir, Daniel Ciurescu, Razvan Diaconescu
    Medicina.2023; 59(8): 1399.     CrossRef
Metabolic risk/Epidemiology
Obesity, Diabetes, and Increased Cancer Progression
Dae-Seok Kim, Philipp E. Scherer
Diabetes Metab J. 2021;45(6):799-812.   Published online November 22, 2021
DOI: https://doi.org/10.4093/dmj.2021.0077
  • 13,993 View
  • 657 Download
  • 70 Web of Science
  • 75 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including liver, pancreatic, endometrial, colorectal, and post-menopausal breast cancer. The path towards developing obesity and diabetes is affected by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, and hyperlipidemia. The metabolic abnormalities associated with changes in the levels of these factors in obesity and diabetes have the potential to significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways. Here, we highlight the cellular and molecular pathways that constitute the links between obesity, diabetes, cancer risk and mortality. This includes a description of the existing evidence supporting the obesity-driven morphological and functional alternations of cancer cells and adipocytes through complex interactions within the tumor microenvironment.

Citations

Citations to this article as recorded by  
  • Triglyceride‐glucose index (TyG index) and endometrial carcinoma risk: A retrospective cohort study
    Haimeng Shi, Feifei Guo, Kang Zheng, Rong Li, Huaijun Zhou
    International Journal of Gynecology & Obstetrics.2024; 164(1): 298.     CrossRef
  • Association between total cholesterol levels and all-cause mortality among newly diagnosed patients with cancer
    Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • The Role of Adipokines in Tumor Progression and Its Association with Obesity
    Jae Won Kim, Jun Hyeok Kim, Yoon Jae Lee
    Biomedicines.2024; 12(1): 97.     CrossRef
  • Triglyceride-glucose index is a risk factor for breast cancer in China: a cross-sectional study
    Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Insulin Resistance: The Increased Risk of Cancers
    Leszek Szablewski
    Current Oncology.2024; 31(2): 998.     CrossRef
  • Epigenetic modifications in obesity‐associated diseases
    Yiqian Long, Chao Mao, Shuang Liu, Yongguang Tao, Desheng Xiao
    MedComm.2024;[Epub]     CrossRef
  • The Juncture of Diabetes, Cancer, and Observational Population-based Studies: Novel Insights From Canadian Provincial Health Records
    Terra Arnason, Kerry Mansell
    Canadian Journal of Diabetes.2024;[Epub]     CrossRef
  • The impact of chemotherapy on adipose tissue remodeling: The molecular players involved in this tissue wasting
    Samuel Barbosa, Mafalda Barbosa Pedrosa, Rita Ferreira, Daniel Moreira-Gonçalves, Lúcio Lara Santos
    Biochimie.2024; 223: 1.     CrossRef
  • Epidemiological and transcriptome data identify shared gene signatures and immune cell infiltration in type 2 diabetes and non-small cell lung cancer
    Qian Yuan, Long Li, Liu-shun Wang, Shi-gui Xing
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • THE INFLUENCE OF DIABETES-ASSOCIATED FACTORS OF ONCOGENESIS ON THE RISK OF BREAST AND ENDOMETRIAL CANCER AND ON THE SURVIVAL OF WOMEN WITH THIS CANCER
    Tamara S. Vatseba, Liubov K. Sokolova, Vasyl Ye. Neyko, Valentyna V. Dzvonkovska, Oksana V. Muravlova, Volodymyr V. Derpak
    Clinical and Preventive Medicine.2024; (2): 99.     CrossRef
  • Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
    Heléna Safadi, Ágnes Balogh, Judit Lám, Attila Nagy, Éva Belicza
    Diabetes Research and Clinical Practice.2024; 211: 111665.     CrossRef
  • Colorectal Cancer: Epidemiology, Risk Factors, and Prevention
    Gholamreza Roshandel, Fatemeh Ghasemi-Kebria, Reza Malekzadeh
    Cancers.2024; 16(8): 1530.     CrossRef
  • Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer
    Antonino Colloca, Isabella Donisi, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D’Onofrio
    Cells.2024; 13(8): 663.     CrossRef
  • Ultra‐processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Guo‐Chao Zhong, Qian Zhu, Dong Cai, Jie‐Jun Hu, Xin Dai, Jian‐Ping Gong, Wei‐Ping Sun
    International Journal of Cancer.2023; 152(5): 835.     CrossRef
  • Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay
    Cristina Pagano, Erika di Zazzo, Giorgio Avilia, Beatrice Savarese, Giovanna Navarra, Maria Chiara Proto, Donatella Fiore, Monica Rienzo, Patrizia Gazzerro, Chiara Laezza, Maurizio Bifulco
    International Journal of Cancer.2023; 152(12): 2464.     CrossRef
  • Metabolites as signalling molecules
    Steven Andrew Baker, Jared Rutter
    Nature Reviews Molecular Cell Biology.2023; 24(5): 355.     CrossRef
  • Characterization of neuroendocrine regulation- and metabolism-associated molecular features and prognostic indicators with aid to clinical chemotherapy and immunotherapy of patients with pancreatic cancer
    Biao Zhang, Qihang Yuan, Bolin Zhang, Shuang Li, Zhizhou Wang, Hangyu Liu, Fanyue Meng, Xu Chen, Dong Shang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Concentration of Selected Adipokines and Factors Regulating Carbohydrate Metabolism in Patients with Head and Neck Cancer in Respect to Their Body Mass Index
    Jarosław Nuszkiewicz, Jolanta Czuczejko, Wiktor Dróżdż, Alina Woźniak, Bogdan Małkowski, Karolina Szewczyk-Golec
    International Journal of Molecular Sciences.2023; 24(4): 3283.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • A novel five-gene metabolism-related risk signature for predicting prognosis and immune infiltration in endometrial cancer: A TCGA data mining
    Huaqing Huang, Xintong Cai, Jiexiang Lin, Qiaoling Wu, Kailin Zhang, Yibin Lin, Bin Liu, Jie Lin
    Computers in Biology and Medicine.2023; 155: 106632.     CrossRef
  • Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
    Ines D. Teixeira, Eugenia Carvalho, Ermelindo C. Leal
    Antibiotics.2023; 12(3): 467.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Relationship Between Physical Exercise and Cognitive Impairment Among Older Adults with Type 2 Diabetes: Chain Mediating Roles of Sleep Quality and Depression
    Han Zhang, Yefan Zhang, Sen Sheng, Yang Xing, Zhongchen Mou, Yanqiu Zhang, Zhixue Shi, Zhenjie Yu, Qianqian Gao, Weiqin Cai, Qi Jing
    Psychology Research and Behavior Management.2023; Volume 16: 817.     CrossRef
  • The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer
    Rosa Divella, Graziella Marino, Stefania Infusino, Laura Lanotte, Gaia Gadaleta-Caldarola, Gennaro Gadaleta-Caldarola
    Nutrients.2023; 15(7): 1667.     CrossRef
  • Distribution of ABO blood groups and Rh factor in benign and malign thyroid nodules
    Muzaffer Serdar DENİZ
    Journal of Health Sciences and Medicine.2023; 6(2): 462.     CrossRef
  • The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer
    Sebastian Stępień, Paweł Olczyk, Joanna Gola, Katarzyna Komosińska-Vassev, Aleksandra Mielczarek-Palacz
    Cells.2023; 12(8): 1118.     CrossRef
  • Coronary Revascularization in Patients With Cancer
    Bala Pushparaji, Teodora Donisan, Dinu Valentin Balanescu, Jong Kun Park, Dominique J. Monlezun, Abdelrahman Ali, Ibrahim Halil Inanc, Jaime Caballero, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, Cezar Iliescu
    Current Treatment Options in Cardiovascular Medicine.2023; 25(6): 143.     CrossRef
  • Hepatocellular carcinoma in a large cohort of type 2 diabetes patients
    Carlo B. Giorda, Roberta Picariello, Barbara Tartaglino, Elisa Nada, Giuseppe Costa, Roberta Manti, Luca Monge, Roberto Gnavi
    Diabetes Research and Clinical Practice.2023; 200: 110684.     CrossRef
  • Prediction of Hypoglycemia in Diabetic Patients During Colonoscopy Preparation
    Xiaohua Lu, Lingqiao Xie, Wane Zhao, Chuangbiao Zhang, Xixi Luo, Yan Zhou
    Experimental and Clinical Endocrinology & Diabetes.2023; 131(05): 274.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin
    Mike R. Wilson, Shannon Harkins, Jake J. Reske, Rebecca A. Siwicki, Marie Adams, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
    Reproductive Biology and Endocrinology.2023;[Epub]     CrossRef
  • The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
    Byungyong Ahn
    International Journal of Molecular Sciences.2023; 24(10): 8811.     CrossRef
  • Mechanism of Cephalophyllum cephalus Intervention in Diabetes Based on Network Pharmacology and Molecular Docking Technology
    志梁 范
    Hans Journal of Medicinal Chemistry.2023; 11(02): 81.     CrossRef
  • Development and validation of a prognostic model based on metabolic risk score to predict overall survival of endometrial cancer in Chinese patients
    Xingchen Li, Xiao Yang, Yuan Cheng, Yangyang Dong, Jingyuan Wang, Jianliu Wang
    Journal of Gynecologic Oncology.2023;[Epub]     CrossRef
  • Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness
    Ting-Yu Chang, Kuo-Cheng Lan, Chia-Hung Wu, Meei-Ling Sheu, Rong-Sen Yang, Shing-Hwa Liu
    Archives of Toxicology.2023; 97(8): 2231.     CrossRef
  • The Link between Diabetes, Pancreatic Tumors, and miRNAs—New Players for Diagnosis and Therapy?
    Małgorzata Kozłowska, Agnieszka Śliwińska
    International Journal of Molecular Sciences.2023; 24(12): 10252.     CrossRef
  • Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions
    Leonardo de Andrade Mesquita, Laura Fink Wayerbacher, Gilberto Schwartsmann, Fernando Gerchman
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • Distinct Lipid Phenotype of Cancer-Associated Fibroblasts (CAFs) Isolated From Overweight/Obese Endometrial Cancer Patients as Assessed Using Raman Spectroscopy
    Tze Hua Yeu, Intan Sofia Omar, S.F. Abdul Sani, Dharini Pathmanathan, Boon Tong Goh, Nithyialakshmi Ravindran, Ik Hui Teo, Yogeeta Gunasagran, Noor Azmi Mat Adenan, Ivy Chung, Amira Hajirah Abd Jamil
    Applied Spectroscopy.2023; 77(7): 723.     CrossRef
  • Global, Regional, and National Epidemiology of Diabetes in Children From 1990 to 2019
    Kexin Zhang, Chengxia Kan, Fang Han, Jingwen Zhang, Chuanhua Ding, Zhentao Guo, Na Huang, Yang Zhang, Ningning Hou, Xiaodong Sun
    JAMA Pediatrics.2023; 177(8): 837.     CrossRef
  • The effects of physical exercise therapy on weight control: its regulation of adipocyte physiology and metabolic capacity
    Hyun Jung Park, Sung Ja Rhie, Insop Shim
    Journal of Exercise Rehabilitation.2023; 19(3): 141.     CrossRef
  • The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells
    Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elv
    Journal of Experimental & Clinical Cancer Research.2023;[Epub]     CrossRef
  • Signal detection in real‐world data and confirmation in clinical trials: Diabetes as a case study for a conversation worth having
    Elad Sharon, Megan Othus, Zoe Eloise Quandt
    Cancer.2023; 129(18): 2769.     CrossRef
  • Ultra-Processed Food Consumption and Obesity in Korean Adults
    Jee-Seon Shim, Kyoung Hwa Ha, Dae Jung Kim, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2023; 47(4): 547.     CrossRef
  • Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer
    Vanda Marques, Fabiola Arella, Marta B. Afonso, André A. Santos, Cecília M.P. Rodrigues
    Clinical Science.2023; 137(15): 1095.     CrossRef
  • Diabetes and two kinds of primary tumors in a patient with thalassemia: a case report and literature review
    Xiaoyan Yu, Yi Peng, Tingting Nie, Wenjia Sun, Yajuan Zhou
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study
    Eyun Song, Soon Young Hwang, Min Jeong Park, Ahreum Jang, Kyeong Jin Kim, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
    Metabolism.2023; 148: 155678.     CrossRef
  • Obesity and Colorectal Cancer
    Jundeok Lee, Su Young Kim
    The Korean Journal of Gastroenterology.2023; 82(2): 63.     CrossRef
  • Cognitive Behavioural Therapies for Weight-Loss in Adults: A Scoping Review Protocol
    Laura María Compañ-Gabucio, Diana Mancheño-Bañón, Laura Torres-Collado, Jesús Vioque, Manuela García-de-la-Hera
    Healthcare.2023; 11(18): 2473.     CrossRef
  • Saxagliptin, a selective dipeptidyl peptidase-4 inhibitor, alleviates somatic cell aneugenicity and clastogenicity in diabetic mice
    Sabry M. Attia, Sheikh F. Ahmad, Ahmed Nadeem, Mohamed S.M. Attia, Mushtaq A. Ansari, Abdelkader E. Ashour, Norah A. Albekairi, Mohammed A. Al-Hamamah, Ali A. Alshamrani, Saleh A. Bakheet
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis.2023; 892: 503707.     CrossRef
  • Mechanisms of Linggui Zhugan Decoction in the Treatment of Obesity Based on Network Pharmacology
    Chunmei Liu, Li Zhang, Yubin Yang
    Science of Advanced Materials.2023; 15(9): 1265.     CrossRef
  • Beyond Body Size: Adiponectin as a Key Player in Obesity-Driven Cancers
    Maurizio Capuozzo, Venere Celotto, Loris Landi, Francesco Ferrara, Francesco Sabbatino, Francesco Perri, Marco Cascella, Vincenza Granata, Mariachiara Santorsola, Alessandro Ottaiano
    Nutrition and Cancer.2023; 75(10): 1848.     CrossRef
  • Impact of sarcopenic obesity on post-hepatectomy bile leakage for hepatocellular carcinoma
    Hikaru Hayashi, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Hitoshi Masuo, Takahiro Yoshizawa, Kiyotaka Hosoda, Hiroki Sakai, Koya Yasukawa, Yuji Soejima, Ezio Lanza
    PLOS ONE.2023; 18(10): e0286353.     CrossRef
  • Colorectal Cancer: From Risk Factors to Oncogenesis
    Vlad Alexandru Ionescu, Gina Gheorghe, Nicolae Bacalbasa, Alexandru Laurentiu Chiotoroiu, Camelia Diaconu
    Medicina.2023; 59(9): 1646.     CrossRef
  • The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
    Barbara Mensah Sankofi, Estefania Valencia-Rincón, Malika Sekhri, Adriana L. Ponton-Almodovar, Jamie J. Bernard, Elizabeth A. Wellberg
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis
    Tingting Kong, Yunpeng Gu, Lei Sun, Run Zhou, Jie Li, Junping Shi
    Endocrine Journal.2023; 70(10): 959.     CrossRef
  • Impact of Caloric Restriction in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Prospective Case Control Study
    Isabella Castellano, Francesco Gallo, Paola Durelli, Taira Monge, Maurizio Fadda, Jasna Metovic, Paola Cassoni, Fulvio Borella, Carlo Raucci, Monica Menischetti, Alessandra Beano, Giuseppe Migliaretti, Concetta Finocchiaro
    Nutrients.2023; 15(21): 4677.     CrossRef
  • Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia
    Na Cui, Wensen Zhang, Fazhi Su, Zhihong Zhang, Biao Li, Donghui Peng, Yanping Sun, Yuanning Zeng, Bingyou Yang, Haixue Kuang, Qiuhong Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Is MG53 a potential therapeutic target for cancer?
    Yunyu Du, Tieying Li, Muqing Yi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Blood Biomarkers Panels for Screening of Colorectal Cancer and Adenoma on a Machine Learning-Assisted Detection Platform
    Hui Wang, Zhiwei Zhou, Haijun Li, Weiguang Xiang, Yilin Lan, Xiaowen Dou, Xiuming Zhang
    Cancer Control.2023;[Epub]     CrossRef
  • Post-treatment serum triglyceride: An effective biomarker for body fat mass and overall survival in esophageal squamous cell cancer patients treated with chemoradiotherapy
    Jiahua Lyu, Ningjing Yang, Wang Guan, Ling Xiao, Xinyu Nie, Long Liang, Hansong Bai, Churong Li, Hao Kuang, Xiao Wang, Tao Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Research Progress of MicroRNA-122 in Obesity and Type 2 Diabetes
    路路 潘
    Advances in Clinical Medicine.2022; 12(06): 5706.     CrossRef
  • Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022
    Ethan Lazarus, Harold Edward Bays
    Obesity Pillars.2022; 3: 100026.     CrossRef
  • Obesity Fact Sheet in Korea, 2021: Trends in Obesity Prevalence and Obesity-Related Comorbidity Incidence Stratified by Age from 2009 to 2019
    Ye Seul Yang, Byoung-Duck Han, Kyungdo Han, Jin-Hyung Jung, Jang Won Son
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 169.     CrossRef
  • Fried food consumption and the risk of pancreatic cancer: A large prospective multicenter study
    Guo-Chao Zhong, Qian Zhu, Jian-Ping Gong, Dong Cai, Jie-Jun Hu, Xin Dai, Jun-Hua Gong
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Intermittent Fasting Is Associated With a Decreased Risk of Age-Related Macular Degeneration
    Eun Young Choi, Min Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Minyoung Lee
    American Journal of Ophthalmology.2022; 243: 1.     CrossRef
  • Metformin Mitigated Obesity-Driven Cancer Aggressiveness in Tumor-Bearing Mice
    Chun-Jung Chen, Chih-Cheng Wu, Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Wen-Ying Chen, Su-Lan Liao, Jiaan-Der Wang
    International Journal of Molecular Sciences.2022; 23(16): 9134.     CrossRef
  • Visceral fat area and body fat percentage measured by bioelectrical impedance analysis correlate with glycometabolism
    Shuying Li, Shaoping Li, Jie Ding, Weihong Zhou
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer
    Roberto Buonaiuto, Fabiana Napolitano, Sara Parola, Pietro De Placido, Valeria Forestieri, Giovanna Pecoraro, Alberto Servetto, Luigi Formisano, Pietro Formisano, Mario Giuliano, Grazia Arpino, Sabino De Placido, Carmine De Angelis
    Biomolecules.2022; 12(10): 1394.     CrossRef
  • Adipokines as Regulators of Autophagy in Obesity-Linked Cancer
    Alin García-Miranda, Alejandra Garcia-Hernandez, Eduardo Castañeda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
    Cells.2022; 11(20): 3230.     CrossRef
  • Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
    Linyue Dong, Heyao Wang, Kaixian Chen, Yiming Li
    Biomedicine & Pharmacotherapy.2022; 156: 113981.     CrossRef
  • Changes in the Fecal Metabolome Accompany an Increase in Aberrant Crypt Foci in the Colon of C57BL/6 Mice Fed with a High-Fat Diet
    Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Andrew D. Magnuson, Matthew J. Picklo
    Biomedicines.2022; 10(11): 2891.     CrossRef
  • Targeting Adiponectin in Breast Cancer
    Rawan Nehme, Mona Diab-Assaf, Caroline Decombat, Laetitia Delort, Florence Caldefie-Chezet
    Biomedicines.2022; 10(11): 2958.     CrossRef
  • Multidisciplinary Progress in Obesity Research
    Xiaoqing Lu, Yuxin Jin, Dexin Li, Jingxin Zhang, Jingyan Han, Yin Li
    Genes.2022; 13(10): 1772.     CrossRef
  • The association between serum copper and obesity and all-cause mortality: the NHANES 2011–2016
    Hongrong Wu, Qingqi Li, Kaifang Zhang, Jianfeng Zhao
    Environmental Science and Pollution Research.2022; 30(11): 31395.     CrossRef
  • The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities
    Christina S. Ennis, Pablo Llevenes, Yuhan Qiu, Ruben Dries, Gerald V. Denis
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
Metabolic Risk/Epidemiology
Computed Tomography-Derived Myosteatosis and Metabolic Disorders
Iva Miljkovic, Chantal A. Vella, Matthew Allison
Diabetes Metab J. 2021;45(4):482-491.   Published online July 30, 2021
DOI: https://doi.org/10.4093/dmj.2020.0277
  • 6,146 View
  • 232 Download
  • 41 Web of Science
  • 44 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
The role of ectopic adipose tissue infiltration into skeletal muscle (i.e., myosteatosis) for metabolic disorders has received considerable and increasing attention in the last 10 years. The purpose of this review was to evaluate and summarize existing studies focusing on computed tomography (CT)-derived measures of myosteatosis and metabolic disorders. There is consistent evidence that CT-derived myosteatosis contributes to dysglycemia, insulin resistance, type 2 diabetes mellitus, and inflammation, and, to some extent, dyslipidemia, independent of general obesity, visceral fat, and other relevant risk factors, suggesting that it may serve as a tool for metabolic risk prediction. Identification of which muscles should be examined, and the standardized CT protocols to be employed, are necessary to enhance the applicability of findings from epidemiologic studies of myosteatosis. Additional and longer longitudinal studies are necessary to confirm a role of myosteatosis in the development of type 2 diabetes mellitus, and examine these associations in a variety of muscles across multiple race/ethnic populations. Given the emerging role of myosteatosis in metabolic health, well-designed intervention studies are needed to investigate relevant lifestyle and pharmaceutical approaches.

Citations

Citations to this article as recorded by  
  • Association of Muscle Fat Content and Muscle Mass With Impaired Lung Function in Young Adults With Obesity: Evaluation With MRI
    Xin Yu, Yan-Hao Huang, You-Zhen Feng, Zhong-Yuan Cheng, Cun-Chuan Wang, Xiang-Ran Cai
    Academic Radiology.2024; 31(1): 9.     CrossRef
  • Subtype-specific Body Composition and Metabolic Risk in Patients With Primary Aldosteronism
    Seung Shin Park, Chang Ho Ahn, Sang Wan Kim, Ji Won Yoon, Jung Hee Kim
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e788.     CrossRef
  • Myosteatosis as a novel predictor of new‐onset diabetes mellitus after kidney transplantation
    Takahito Wakamiya, Takuya Fujimoto, Takahito Endo, Shun Nishioka, Naoki Yokoyama, Shimpei Yamashita, Kazuro Kikkawa, Yoji Hyodo, Takeshi Ishimura, Yasuo Kohjimoto, Isao Hara, Masato Fujisawa
    International Journal of Urology.2024; 31(1): 39.     CrossRef
  • Predictors of visceral and subcutaneous adipose tissue and muscle density: The ShapeUp! Kids study
    Gertraud Maskarinec, Yurii Shvetsov, Michael C. Wong, Devon Cataldi, Jonathan Bennett, Andrea K. Garber, Steven D. Buchthal, Steven B. Heymsfield, John A. Shepherd
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 799.     CrossRef
  • Association of daily carbohydrate intake with intermuscular adipose tissue in Korean individuals with obesity: a cross-sectional study
    Ha-Neul Choi, Young-Seol Kim, Jung-Eun Yim
    Nutrition Research and Practice.2024; 18(1): 78.     CrossRef
  • Myosteatosis is associated with poor survival after kidney transplantation: a large retrospective cohort validation
    Jie Chen, Yue Li, Chengjie Li, Turun Song
    Abdominal Radiology.2024; 49(4): 1210.     CrossRef
  • Regenerative rehabilitation measures to restore tissue function after arsenic exposure
    Adam A. Jasper, Kush H. Shah, Helmet Karim, Swathi Gujral, Iva Miljkovic, Caterina Rosano, Aaron Barchowsky, Amrita Sahu
    Current Opinion in Biomedical Engineering.2024; 30: 100529.     CrossRef
  • Impact of CFTR Modulator Therapy on Body Composition as Assessed by Thoracic Computed Tomography: A Follow-Up Study
    Víctor Navas-Moreno, Fernando Sebastian-Valles, Víctor Rodríguez-Laval, Carolina Knott-Torcal, Mónica Marazuela, Nuria Sánchez de la Blanca, Jose Alfonso Arranz Martín, Rosa María Girón, Miguel Antonio Sampedro-Núñez
    Nutrition.2024; : 112425.     CrossRef
  • Myosteatosis predicts postoperative complications and long‐term survival in robotic gastrectomy for gastric cancer: A propensity score analysis
    Pingan Ding, Jiaxiang Wu, Haotian Wu, Tongkun Li, Jiaxuan Yang, Li Yang, Honghai Guo, Yuan Tian, Peigang Yang, Lingjiao Meng, Qun Zhao
    European Journal of Clinical Investigation.2024;[Epub]     CrossRef
  • A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence
    Eunhye Seo, Yeongkeun Kwon, Ahmad ALRomi, Mohannad Eledreesi, Sungsoo Park
    Reviews in Endocrine and Metabolic Disorders.2024;[Epub]     CrossRef
  • Body Composition at CT and Risk of Future Disease
    Michael A. Ohliger
    Radiology.2023;[Epub]     CrossRef
  • Association between hypertension and myosteatosis evaluated by abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Hypertension Research.2023; 46(4): 845.     CrossRef
  • Muscle fat infiltration in chronic kidney disease: a marker related to muscle quality, muscle strength and sarcopenia
    Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
    Journal of Nephrology.2023; 36(3): 895.     CrossRef
  • Myosteatosis: a potential missing link between hypertension and metabolic disorder in the Asian population
    Minyoung Lee, Sungha Park
    Hypertension Research.2023; 46(6): 1603.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • Association between sarcopenic obesity and poor muscle quality based on muscle quality map and abdominal computed tomography
    Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Joong‐Yeol Park, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
    Obesity.2023; 31(6): 1547.     CrossRef
  • Chest CT opportunistic biomarkers for phenotyping high-risk COVID-19 patients: a retrospective multicentre study
    Anna Palmisano, Chiara Gnasso, Alberto Cereda, Davide Vignale, Riccardo Leone, Valeria Nicoletti, Simone Barbieri, Marco Toselli, Francesco Giannini, Marco Loffi, Gianluigi Patelli, Alberto Monello, Gianmarco Iannopollo, Davide Ippolito, Elisabetta Maria
    European Radiology.2023; 33(11): 7756.     CrossRef
  • Early menopause and premature ovarian insufficiency may increase the risk of sarcopenia: A systematic review and meta-analysis
    Efstathios Divaris, Panagiotis Anagnostis, Nifon K. Gkekas, Evangelia Kouidi, Dimitrios G. Goulis
    Maturitas.2023; 175: 107782.     CrossRef
  • The Important Role of Intermuscular Adipose Tissue on Metabolic Changes Interconnecting Obesity, Ageing and Exercise: A Systematic Review
    I Gusti Putu Suka Aryana, Ivana Beatrice Paulus, Sanjay Kalra, Dian Daniella, Raden Ayu Tuty Kuswardhani, Ketut Suastika, Sony Wibisono
    European Endocrinology.2023; 19(1): 54.     CrossRef
  • Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
    Caterina Rosano, Anne Newman, Adam Santanasto, Xiaonan Zhu, Bret Goodpaster, Iva Miljkovic
    Journal of the American Geriatrics Society.2023; 71(9): 2759.     CrossRef
  • Myosteatosis and bone marrow adiposity are not associated among postmenopausal women with fragility fractures
    Sammy Badr, Héloïse Dapvril, Daniela Lombardo, Huda Khizindar, Claire Martin, Bernard Cortet, Anne Cotten, Julien Paccou
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Relationship between trunk intramuscular adipose tissue content and prevalence of metabolic syndrome in middle-aged Japanese men
    Noriko I. Tanaka, Masataka Suwa, Hisashi Maeda, Aya Tomita, Takayuki Imoto, Hiroshi Akima
    Nutrition.2023; 113: 112083.     CrossRef
  • Skeletal muscle alterations indicate poor prognosis in cirrhotic patients: a multicenter cohort study in China
    Xin Zeng, Zhi-Wen Shi, Jia-Jun Yu, Li-Fen Wang, Chun-Yan Sun, Yuan-Yuan Luo, Pei-Mei Shi, Yong Lin, Yue-Xiang Chen, Jia Guo, Chun-Qing Zhang, Wei-Fen Xie
    Hepatology International.2023;[Epub]     CrossRef
  • Sarcopenic obesity and its relation with muscle quality and mortality in patients on chronic hemodialysis
    Alice Sabatino, Carla Maria Avesani, Giuseppe Regolisti, Marianna Adinolfi, Giuseppe Benigno, Marco Delsante, Enrico Fiaccadori, Ilaria Gandolfini
    Clinical Nutrition.2023; 42(8): 1359.     CrossRef
  • Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women
    Adrianna I. Acevedo‐Fontánez, Ryan K. Cvejkus, Joseph M. Zmuda, Allison L. Kuipers, Emma Barinas‐Mitchell, Akira Sekikawa, Victor Wheeler, Caterina Rosano, Iva Miljkovic
    Obesity.2023; 31(9): 2398.     CrossRef
  • Obesity, Sarcopenia and Myosteatosis: Impact on Clinical Outcomes in the Operative Management of Crohn’s Disease
    Mark Donnelly, Dorothee Driever, Éanna J Ryan, Jessie A Elliott, John Finnegan, Deirdre McNamara, Ian Murphy, Kevin C Conlon, Paul C Neary, Dara O Kavanagh, James M O’Riordan
    Inflammatory Bowel Diseases.2023;[Epub]     CrossRef
  • Meld-sarcopenia score and skeletal muscle density predicts short-term readmission of patients with hepatic encephalopathy
    Shuo Yang, Lin Zhang, Qian Jin, Jian Wang, Danli Ma, Jie Gao, Rui Huang
    European Journal of Radiology.2023; 169: 111178.     CrossRef
  • Muscle Fat Content Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Chinese Adults
    W. Guo, X. Zhao, D. Cheng, X. Liang, M. Miao, X. Li, J. Lu, N. Xu, Shuang Hu, Qun Zhang
    The Journal of nutrition, health and aging.2023; 27(11): 960.     CrossRef
  • Association between relative muscle strength and hypertension in middle-aged and older Chinese adults
    Jin-hua Luo, Tu-ming Zhang, Lin-lin Yang, Yu-ying Cai, Yu Yang
    BMC Public Health.2023;[Epub]     CrossRef
  • Dynapenic Abdominal Obesity as a Risk Factor for Metabolic Syndrome in Individual 50 Years of Age or Older: English Longitudinal Study of Ageing
    P.C. Ramírez, R. de Oliveira Máximo, D. Capra de Oliveira, A.F. de Souza, M. Marques Luiz, M. L. Bicigo Delinocente, A. Steptoe, C. de Oliveira, Tiago da Silva Alexandre
    The Journal of nutrition, health and aging.2023; 27(12): 1188.     CrossRef
  • Editorial Comment to Myosteatosis as a novel predictor of urinary incontinence after robot‐assisted radical prostatectomy
    Nobuhiro Haga, Naotaka Gunge, Hiroshi Matsuzaki, Yu Okabe, Takeshi Miyazaki
    International Journal of Urology.2022; 29(1): 40.     CrossRef
  • Ammonia and the Muscle: An Emerging Point of View on Hepatic Encephalopathy
    Simone Di Cola, Silvia Nardelli, Lorenzo Ridola, Stefania Gioia, Oliviero Riggio, Manuela Merli
    Journal of Clinical Medicine.2022; 11(3): 611.     CrossRef
  • Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
    Jae-Young Lim, Walter R. Frontera
    European Journal of Applied Physiology.2022; 122(6): 1383.     CrossRef
  • Sarcopenia in Patients with Cirrhosis after Transjugular Intrahepatic Portosystemic Shunt Placement
    Jiacheng Liu, Jinqiang Ma, Chongtu Yang, Manman Chen, Qin Shi, Chen Zhou, Songjiang Huang, Yang Chen, Yingliang Wang, Tongqiang Li, Bin Xiong
    Radiology.2022; 303(3): 711.     CrossRef
  • Myosteatosis Significantly Predicts Persistent Dyspnea and Mobility Problems in COVID-19 Survivors
    Rebecca De Lorenzo, Anna Palmisano, Antonio Esposito, Chiara Gnasso, Valeria Nicoletti, Riccardo Leone, Davide Vignale, Elisabetta Falbo, Marica Ferrante, Marta Cilla, Cristiano Magnaghi, Sabina Martinenghi, Giordano Vitali, Alessio Molfino, Patrizia Rove
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Prognostic value of myosteatosis in patients with lung cancer: a systematic review and meta-analysis
    Shaofang Feng, Huiwen Mu, Rong Hou, Yunxin Liu, Jianjun Zou, Zheng Zhao, Yubing Zhu
    International Journal of Clinical Oncology.2022; 27(7): 1127.     CrossRef
  • Muscle Fat Content Is Strongly Associated With Hyperuricemia: A Cross-Sectional Study in Chinese Adults
    Ningxin Chen, Tingting Han, Hongxia Liu, Jie Cao, Wenwen Liu, Didi Zuo, Ting Zhang, Xiucai Lan, Xian Jin, Yurong Weng, Yaomin Hu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Advances in muscle health and nutrition: A toolkit for healthcare professionals
    Carla M. Prado, Francesco Landi, Samuel T.H. Chew, Philip J. Atherton, Jeroen Molinger, Tobias Ruck, Maria Cristina Gonzalez
    Clinical Nutrition.2022; 41(10): 2244.     CrossRef
  • Factors related to trunk intramuscular adipose tissue content – A comparison of younger and older men
    Funa Kitagawa, Madoka Ogawa, Akito Yoshiko, Yoshiharu Oshida, Teruhiko Koike, Hiroshi Akima, Noriko I. Tanaka
    Experimental Gerontology.2022; 168: 111922.     CrossRef
  • Association of myosteatosis with various body composition abnormalities and longer length of hospitalization in patients with decompensated cirrhosis
    Xiaoyu Wang, Mingyu Sun, Yifan Li, Gaoyue Guo, Wanting Yang, Lihong Mao, Zihan Yu, Yangyang Hui, Xiaofei Fan, Binxin Cui, Kui Jiang, Chao Sun
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Peripheral bone structure, geometry, and strength and muscle density as derived from peripheral quantitative computed tomography and mortality among rural south Indian older adults
    Guru Rajesh Jammy, Robert M. Boudreau, Iva Miljkovic, Pawan Kumar Sharma, Sudhakar Pesara Reddy, Susan L. Greenspan, Anne B. Newman, Jane A. Cauley, Bert B. Little
    PLOS Global Public Health.2022; 2(10): e0000333.     CrossRef
  • Muscle fat contents rather than muscle mass determines nonalcoholic steatohepatitis and liver fibrosis in patients with severe obesity
    Eugene Han, Mi Kyung Kim, Hye Won Lee, Seungwan Ryu, Hye Soon Kim, Byoung Kuk Jang, Youngsung Suh
    Obesity.2022; 30(12): 2440.     CrossRef
  • Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease
    Pei Xiao, Pu Liang, Panjun Gao, Jinyi Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Imaging based body composition profiling and outcomes after oncologic liver surgery
    Lorenzo Bernardi, Raffaello Roesel, Filippo Vagelli, Pietro Majno-Hurst, Alessandra Cristaudi
    Frontiers in Oncology.2022;[Epub]     CrossRef
Basic Research
Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Okamatsu-Ogura Yuko, Masayuki Saito
Diabetes Metab J. 2021;45(6):840-852.   Published online June 25, 2021
DOI: https://doi.org/10.4093/dmj.2020.0291
  • 8,977 View
  • 504 Download
  • 16 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.

Citations

Citations to this article as recorded by  
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
    Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
    Biochemical Pharmacology.2024; 220: 116012.     CrossRef
  • Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
    Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
    Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
  • Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
    Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
    Biomolecules.2024; 14(4): 483.     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
    Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
    iScience.2023; 26(7): 107239.     CrossRef
  • In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
    Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
    Journal of Applied Physiology.2023; 135(2): 251.     CrossRef
  • Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Journal of Evolutionary Biochemistry and Physiology.2023; 59(4): 1020.     CrossRef
  • UNCOUPLING PROTEIN UCP1 EXPRESSION DYNAMICS IN ADIPOSE TISSUES OF THE OUTBRED ICR MICE IN POSTNATAL ONTOGENESIS
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Журнал эволюционной биохимии и физиологии.2023; 59(4): 255.     CrossRef
  • Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
    Sunghyun Kang, Hwan-Woo Park, Kyung Ho Han
    International Journal of Molecular Sciences.2022; 23(14): 7834.     CrossRef
  • Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
    Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Possible roles of exercise and apelin against pregnancy complications
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Relationships between the expression of adipose genes and profiles of hospitalized dogs
    Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama, Takashi Kobayashi, Yusuke Yamashita, Kei Kazama, Ken Onda, Masayuki Funaba, Masaru Murakami
    Veterinary Research Communications.2022; 46(4): 1239.     CrossRef
  • Garlic (Allium sativum L.) in diabetes and its complications: Recent advances in mechanisms of action
    Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
    Critical Reviews in Food Science and Nutrition.2022; : 1.     CrossRef
  • Fruit of Gardenia jasminoides Induces Mitochondrial Activation and Non-Shivering Thermogenesis through Regulation of PPARγ
    Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
    Antioxidants.2021; 10(9): 1418.     CrossRef
Original Articles
Basic Research
Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway
Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
Diabetes Metab J. 2021;45(6):921-932.   Published online February 22, 2021
DOI: https://doi.org/10.4093/dmj.2020.0187
  • 8,417 View
  • 410 Download
  • 20 Web of Science
  • 21 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs that exhibit multiple extraglycemic effects. However, there are conflicting results regarding the effects of SGLT2 inhibition on energy expenditure and thermogenesis. Therefore, we investigated the effect of ipragliflozin (a selective SGLT2 inhibitor) on energy metabolism.
Methods
Six-week-old male 129S6/Sv mice with a high propensity for adipose tissue browning were randomly assigned to three groups: normal chow control, 60% high-fat diet (HFD)-fed control, and 60% HFD-fed ipragliflozin-treated groups. The administration of diet and medication was continued for 16 weeks.
Results
The HFD-fed mice became obese and developed hepatic steatosis and adipose tissue hypertrophy, but their random glucose levels were within the normal ranges; these features are similar to the metabolic features of a prediabetic condition. Ipragliflozin treatment markedly attenuated HFD-induced hepatic steatosis and reduced the size of hypertrophied adipocytes to that of smaller adipocytes. In the ipragliflozin treatment group, uncoupling protein 1 (Ucp1) and other thermogenesis-related genes were significantly upregulated in the visceral and subcutaneous adipose tissue, and fatty acid oxidation was increased in the brown adipose tissue. These effects were associated with a significant reduction in the insulin-to-glucagon ratio and the activation of the AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1) pathway in the liver and adipose tissue.
Conclusion
SGLT2 inhibition by ipragliflozin showed beneficial metabolic effects in 129S6/Sv mice with HFD-induced obesity that mimics prediabetic conditions. Our data suggest that SGLT2 inhibitors, through their upregulation of energy expenditure, may have therapeutic potential in prediabetic obesity.

Citations

Citations to this article as recorded by  
  • SGLT2 inhibitors and AMPK: The road to cellular housekeeping?
    Nasser Safaie, Shahab Masoumi, Shaban Alizadeh, Pourya Mirzajanzadeh, Hamid Reza Nejabati, Mobasher Hajiabbasi, Vahid Alivirdiloo, Neda Chobdari Basmenji, Aysan Derakhshi Radvar, Ziba Majidi, Yousef Faridvand
    Cell Biochemistry and Function.2024;[Epub]     CrossRef
  • Mechanisms of SGLT2 Inhibitors in Heart Failure and Their Clinical Value
    Yafei Xie, Yujie Wei, Dan Li, Jie Pu, Hong Ding, Xiaowei Zhang
    Journal of Cardiovascular Pharmacology.2023; 81(1): 4.     CrossRef
  • Current Treatment Options, Including Diet, Exercise, and Medications
    Mazen Noureddin, Manal F. Abdelmalek
    Clinics in Liver Disease.2023; 27(2): 397.     CrossRef
  • SGLT2 Inhibitors and Kidney Diseases: A Clinical Perspective
    Panagiotis Theofilis, Rigas G. Kalaitzidis
    Current Medicinal Chemistry.2023; 30(23): 2595.     CrossRef
  • Treatment of obesity-related diabetes: significance of thermogenic adipose tissue and targetable receptors
    Ruping Pan, Jiadai Liu, Yong Chen
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Immunomodulatory Effects of SGLT2 Inhibitors—Targeting Inflammation and Oxidative Stress in Aging
    Ema Schönberger, Vjera Mihaljević, Kristina Steiner, Sandra Šarić, Tomislav Kurevija, Ljiljana Trtica Majnarić, Ines Bilić Ćurčić, Silvija Canecki-Varžić
    International Journal of Environmental Research and Public Health.2023; 20(17): 6671.     CrossRef
  • SGLT‐2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat PCOS model
    Manal Moustafa Mahmoud, Laila Ahmed Rashed, Somia Abdulatif Soliman, Safaa Mostafa Sayed, Omneya Kamel, Samaa Samir Kamar, Rania El Sayed Hussien
    Physiological Reports.2023;[Epub]     CrossRef
  • Resting energy expenditure based on equation estimation can predict renal outcomes in patients with type 2 diabetes mellitus and biopsy-proven diabetic kidney disease
    Xiang Xiao, Shuming Ji, Junlin Zhang, Deying Kang, Fang Liu
    Renal Failure.2023;[Epub]     CrossRef
  • Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
    Zhicheng Gao, Jiaqi Bao, Yilan Hu, Junjie Tu, Lifang Ye, Lihong Wang
    Current Drug Targets.2023; 24(13): 1009.     CrossRef
  • SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1
    Weijie Wang, Yilan Li, Yanxiu Zhang, Tao Ye, Kui Wang, Shuijie Li, Yao Zhang
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling
    Ke Lin, Na Yang, Wu Luo, Jin-fu Qian, Wei-wei Zhu, Shi-ju Ye, Chen-xin Yuan, Di-yun Xu, Guang Liang, Wei-jian Huang, Pei-ren Shan
    Acta Pharmacologica Sinica.2022; 43(10): 2624.     CrossRef
  • Pleiotropic effects of SGLT2 inhibitors and heart failure outcomes
    Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Gerasimos Siasos, Kostas Tsioufis, Dimitris Tousoulis
    Diabetes Research and Clinical Practice.2022; 188: 109927.     CrossRef
  • Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models
    Sandra Feijóo-Bandín, Alana Aragón-Herrera, Manuel Otero-Santiago, Laura Anido-Varela, Sandra Moraña-Fernández, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago
    International Journal of Molecular Sciences.2022; 23(10): 5634.     CrossRef
  • Potential molecular mechanism of action of sodium-glucose co-transporter 2 inhibitors in the prevention and management of diabetic retinopathy
    Lia Meuthia Zaini, Arief S Kartasasmita, Tjahjono D Gondhowiardjo, Maimun Syukri, Ronny Lesmana
    Expert Review of Ophthalmology.2022; 17(3): 199.     CrossRef
  • New insights and advances of sodium-glucose cotransporter 2 inhibitors in heart failure
    Juexing Li, Lei Zhou, Hui Gong
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis
    Milton Packer
    Circulation.2022; 146(18): 1383.     CrossRef
  • Nutraceutical activation of Sirt1: a review
    James J DiNicolantonio, Mark F McCarty, James H O'Keefe
    Open Heart.2022; 9(2): e002171.     CrossRef
  • Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells
    Jing Xu, Munehiro Kitada, Yoshio Ogura, Haijie Liu, Daisuke Koya
    Cells.2021; 10(6): 1457.     CrossRef
  • Could Sodium/Glucose Co-Transporter-2 Inhibitors Have Antiarrhythmic Potential in Atrial Fibrillation? Literature Review and Future Considerations
    Dimitrios A. Vrachatis, Konstantinos A. Papathanasiou, Konstantinos E. Iliodromitis, Sotiria G. Giotaki, Charalampos Kossyvakis, Konstantinos Raisakis, Andreas Kaoukis, Vaia Lambadiari, Dimitrios Avramides, Bernhard Reimers, Giulio G. Stefanini, Michael C
    Drugs.2021; 81(12): 1381.     CrossRef
  • Differential Pathophysiological Mechanisms in Heart Failure With a Reduced or Preserved Ejection Fraction in Diabetes
    Milton Packer
    JACC: Heart Failure.2021; 9(8): 535.     CrossRef
  • Ketone bodies: from enemy to friend and guardian angel
    Hubert Kolb, Kerstin Kempf, Martin Röhling, Martina Lenzen-Schulte, Nanette C. Schloot, Stephan Martin
    BMC Medicine.2021;[Epub]     CrossRef
Others
Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical Mixtures? Association between Physical Activity and Persistent Organic Pollutants
Yu-Mi Lee, Ji-Yeon Shin, Se-A Kim, David R. Jacobs, Duk-Hee Lee
Diabetes Metab J. 2020;44(5):764-774.   Published online May 11, 2020
DOI: https://doi.org/10.4093/dmj.2019.0158
  • 5,354 View
  • 87 Download
  • 5 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs), have emerged as a new risk factor of many chronic diseases. As serum concentrations of POPs in humans are mainly determined by both their release from adipose tissue to circulation and their elimination from circulation, management of these internal pathways may be important in controlling the serum concentrations of POPs. As habitual physical activity can increase the elimination of POPs from circulation, we evaluated whether chronic physical activity is related to low serum POP concentrations.

Methods

A cross-sectional study of 1,850 healthy adults (age ≥20 years) without cardio-metabolic diseases who participated in the U.S. National Health and Nutrition Examination Survey 1999 to 2004 was conducted. Information on moderate or vigorous leisure-time physical activity was obtained based on questionnaires. Serum concentrations of OCPs and polychlorinated biphenyls were investigated as typical POPs.

Results

Serum concentrations of OCPs among physically active subjects were significantly lower than those among physically inactive subjects (312.8 ng/g lipid vs. 538.0 ng/g lipid, P<0.001). This difference was maintained after adjustment for potential confounders. When analyses were restricted to physically active subjects, there were small decreases in the serum concentrations of OCPs with increasing duration of physical activity, showing a curvilinear relationship over the whole range of physical activity (Pquadratic <0.001). In analyses stratified by age, sex, body mass index, and smoking status, a strong inverse association was similarly observed among all subgroups.

Conclusion

Physical activity may assist in decreasing serum concentrations of lipophilic chemical mixtures such as OCPs.

Citations

Citations to this article as recorded by  
  • Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review
    Quentin A. Serrano, Sébastien Le Garf, Vincent Martin, Serge S. Colson, Nicolas Chevalier
    International Journal of Molecular Sciences.2024; 25(2): 883.     CrossRef
  • Physical exercise and persistent organic pollutants
    Chang Liu, Hui sheng Hou
    Heliyon.2023; 9(9): e19661.     CrossRef
  • Exposure to a low concentration of mixed organochlorine pesticides impairs glucose metabolism and mitochondrial function in L6 myotubes and zebrafish
    Chul-Min Park, Ki-Tae Kim, Dong-Young Rhyu
    Journal of Hazardous Materials.2021; 414: 125437.     CrossRef
  • Can Environmental Pollutants Be a Factor Linking Obesity and COVID-19?
    Duk-Hee Lee
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Letter to the Editor: Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial
    Yu-Mi Lee, Duk-Hee Lee
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(5): 849.     CrossRef
  • Can habitual exercise really increase serum concentrations of persistent organic pollutants?
    Yu-Mi Lee, Duk-Hee Lee
    Environment International.2020; 140: 105615.     CrossRef
  • Response to correspondence ENVINT_2020_552 “Can habitual exercise really increase serum concentrations of persistent organic pollutants?”
    Sidsel L. Domazet, Tina K. Jensen, Anders Grøntved
    Environment International.2020; 140: 105616.     CrossRef
Reviews
Obesity and Metabolic Syndrome
Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors
Injae Hwang, Jae Bum Kim
Diabetes Metab J. 2019;43(6):752-762.   Published online December 26, 2019
DOI: https://doi.org/10.4093/dmj.2019.0174
  • 8,848 View
  • 178 Download
  • 36 Web of Science
  • 38 Crossref
AbstractAbstract PDFPubReader   

Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.

Citations

Citations to this article as recorded by  
  • Lipodystrophy as a target to delay premature aging
    Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
    Trends in Endocrinology & Metabolism.2024; 35(2): 97.     CrossRef
  • Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
    Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi
    PLOS ONE.2024; 19(1): e0296833.     CrossRef
  • NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
    Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li
    Animals.2024; 14(4): 585.     CrossRef
  • Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice
    Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton
    European Journal of Nutrition.2023; 62(1): 321.     CrossRef
  • Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice
    Weihao Chen, Fengyan Meng, Xianyin Zeng, Xiaohan Cao, Guixian Bu, Xiaogang Du, Guozhi Yu, Fanli Kong, Yunkun Li, Tian Gan, Xingfa Han
    International Journal of Molecular Sciences.2023; 24(3): 2308.     CrossRef
  • High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life
    Guadalupe L. Rodríguez-González, Sergio De Los Santos, Dayana Méndez-Sánchez, Luis A. Reyes-Castro, Carlos A. Ibáñez, Patricia Canto, Elena Zambrano
    British Journal of Nutrition.2023; 130(5): 783.     CrossRef
  • Obesity and the risk of cardiometabolic diseases
    Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia
    Nature Reviews Cardiology.2023; 20(7): 475.     CrossRef
  • Abdominal fat and muscle distributions in different stages of colorectal cancer
    Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
    BMC Cancer.2023;[Epub]     CrossRef
  • Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
    Sofía Elena Tesolato, Daniel González-Gamo, Ana Barabash, Paula Claver, Sofía Cristina de la Serna, Inmaculada Domínguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio José Torres, Pilar Iniesta
    Cancers.2023; 15(13): 3324.     CrossRef
  • Lower subcutaneous fat index predicts bone metastasis in breast cancer
    Wen Wang, Wen-Juan Huang, Ping-Ping Liu, Shuang Fu, Meng-Lin Zhang, Xin Zhang, Rui-Tao Wang, Yuan-Xi Huang
    Cancer Biomarkers.2023; 38(1): 121.     CrossRef
  • RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
    Agnieszka Mikłosz, Bartłomiej Łukaszuk, Elżbieta Supruniuk, Kamil Grubczak, Magdalena Kusaczuk, Adrian Chabowski
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
    Griselda Rabadán-Chávez, Rocío I. Díaz de la Garza, Daniel A. Jacobo-Velázquez
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166853.     CrossRef
  • Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
    Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
    Cancer Biomarkers.2023; : 1.     CrossRef
  • Histological pattern and gene expression profiling of thyroid tissue in subjects with obesity
    A. Basolo, A. M. Poma, R. Giannini, G. Ceccarini, C. Pelosini, P. Fierabracci, M. U. Castany, S. Bechi Genzano, C. E. Ambrosini, G. Materazzi, L. Chiovato, F. Basolo, F. Santini, L. Torregrossa
    Journal of Endocrinological Investigation.2022; 45(2): 413.     CrossRef
  • Predictors of non-alcoholic fatty liver disease in children
    Menglong Li, Wen Shu, Jiawulan Zunong, Nubiya Amaerjiang, Huidi Xiao, Dan Li, Sten H. Vermund, Yifei Hu
    Pediatric Research.2022; 92(1): 322.     CrossRef
  • Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
    Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
    Cell Metabolism.2022; 34(3): 458.     CrossRef
  • WT1 in Adipose Tissue: From Development to Adult Physiology
    Karin M. Kirschner, Holger Scholz
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Shall We Begin the Voyage of Adipose Tissue Exploration?
    Yong Geun Jeon
    Molecules and Cells.2022; 45(6): 362.     CrossRef
  • Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
    Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke
    The EMBO Journal.2022;[Epub]     CrossRef
  • The fates of different types of adipose tissue after transplantation in mice
    Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
    The FASEB Journal.2022;[Epub]     CrossRef
  • Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
    Jun Han, Zuoyou Ding, Qiulin Zhuang, Lei Shen, Fan Yang, Szechun Sah, Guohao Wu
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
    Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
    International Journal of Molecular Sciences.2022; 23(3): 1543.     CrossRef
  • Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
    Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández, Albert Lecube
    Nutrients.2022; 15(1): 203.     CrossRef
  • Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
    Alice Chaplin, Ramon Maria Rodriguez, Juan José Segura-Sampedro, Aina Ochogavía-Seguí, Dora Romaguera, Gwendolyn Barceló-Coblijn
    International Journal of Molecular Sciences.2022; 23(21): 13128.     CrossRef
  • Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks
    Paula M. Lorenzo, Ana B. Crujeiras
    Food & Function.2021; 12(4): 1402.     CrossRef
  • Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
    Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
    International Journal of Molecular Sciences.2021; 22(2): 966.     CrossRef
  • Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
    Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Ceramides and Sphingosino-1-Phosphate in Obesity
    Ilona Juchnicka, Mariusz Kuźmicki, Jacek Szamatowicz
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
    Christine Bourgeois, Jennifer Gorwood, Anaelle Olivo, Laura Le Pelletier, Jacqueline Capeau, Olivier Lambotte, Véronique Béréziat, Claire Lagathu
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia
    Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
    Clinical Nutrition.2021; 40(9): 5156.     CrossRef
  • miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients
    Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands
    Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
    Cells.2021; 10(12): 3560.     CrossRef
  • Obesity: The Crossroads of Opinion, Knowledge, and Opportunity
    L. A. Ruyatkina, D. S. Ruyatkin
    Meditsinskiy sovet = Medical Council.2020; (7): 108.     CrossRef
  • Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring
    Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
    Endocrinology.2020;[Epub]     CrossRef
  • Adipose stem cells in obesity: challenges and opportunities
    Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang
    Bioscience Reports.2020;[Epub]     CrossRef
  • Clinical and pathogenetic rationale for the prevention and treatment of obesity
    O.M. Korzh
    Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2020; 2020(2): 146.     CrossRef
  • OBESITY: CLINICAL AND PATHOGENETIC JUSTIFICATION OF PREVENTION AND TREATMENT
    O. M. Korzh
    International Medical Journal.2020; (2): 5.     CrossRef
  • The Effect and Mechanism of Subcutaneous and Visceral Adipose Tissue Loss on Gastric Cancer Patients With Cachexia
    Jun Han, Min Tang, Guyue Zhang, Chaocheng Lu, Jiaqi She, Guohao Wu
    SSRN Electronic Journal .2020;[Epub]     CrossRef
Pathophysiology
Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
Yea Eun Kang, Hyun Jin Kim, Minho Shong
Diabetes Metab J. 2019;43(5):549-559.   Published online October 24, 2019
DOI: https://doi.org/10.4093/dmj.2019.0157
  • 6,699 View
  • 93 Download
  • 9 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   

Obesity results in an inflammatory microenvironment in adipose tissue, leading to the deterioration of tissue protective mechanisms. Although recent studies suggested the importance of type 2 immunity in an anti-inflammatory microenvironment in adipose tissue, the regulatory effects of T helper 2 (Th2) cytokines on systemic metabolic regulation are not fully understood. Recently, we identified the roles of the Th2 cytokine (interleukin 4 [IL-4] and IL-13)-induced adipokine, growth differentiation factor 15 (GDF15), in adipose tissue in regulating systemic glucose metabolism via signal transducer and activator of transcription 6 (STAT6) activation. Moreover, we showed that mitochondrial oxidative phosphorylation is required to maintain these macrophage-regulating autocrine and paracrine signaling pathways via Th2 cytokine-induced secretion of GDF15. In this review, we discuss how the type 2 immune response and Th2 cytokines regulate metabolism in adipose tissue. Specifically, we review the systemic regulatory roles of Th2 cytokines in metabolic disease and the role of mitochondria in maintenance of type 2 responses in adipose tissue homeostasis.

Citations

Citations to this article as recorded by  
  • Orchestration of the Adipose Tissue Immune Landscape by Adipocytes
    David Bradley, Tuo Deng, Dharti Shantaram, Willa A. Hsueh
    Annual Review of Physiology.2024; 86(1): 199.     CrossRef
  • Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease
    Balázs Bence Nyárády, Loretta Zsuzsa Kiss, Zsolt Bagyura, Béla Merkely, Edit Dósa, Orsolya Láng, László Kőhidai, Éva Pállinger
    Biomedicine & Pharmacotherapy.2024; 174: 116475.     CrossRef
  • Evaluation of Mitochondrial Function in Blood Samples Shows Distinct Patterns in Subjects with Thyroid Carcinoma from Those with Hyperplasia
    Julia Bernal-Tirapo, María Teresa Bayo Jiménez, Pedro Yuste-García, Isabel Cordova, Ana Peñas, Francisco-Javier García-Borda, Cesar Quintela, Ignacio Prieto, Cristina Sánchez-Ramos, Eduardo Ferrero-Herrero, María Monsalve
    International Journal of Molecular Sciences.2023; 24(7): 6453.     CrossRef
  • A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
    Ronit Vogt Sionov, Ronit Ahdut-HaCohen
    Biomedicines.2023; 11(9): 2558.     CrossRef
  • Gdf15 deletion exacerbates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice
    Mengyun Deng, Duo Su, Nan Xiao, Zhipeng Zhang, Yifeng Wang, Fuliang Zong, Sha Li, Jinglin Wang, Dongsheng Zhou, Yuee Zhao, Huiying Yang
    Toxicology.2022; 469: 153135.     CrossRef
  • Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies
    Jian Wu, Min Zhang, Allison Faircloth
    Hemato.2022; 3(3): 422.     CrossRef
  • Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
    Liwen Wang, Jie Hu, Haiyan Zhou
    The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
  • Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver
    Seul-Gi Kang, Seong-Eun Lee, Min-Jeong Choi, Joon-Young Chang, Jung-Tae Kim, Ben-Yuan Zhang, Yea-Eun Kang, Ju-Hee Lee, Hyon-Seung Yi, Minho Shong
    Cells.2021; 10(6): 1298.     CrossRef
  • Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
    Jörg Wischhusen, Ignacio Melero, Wolf Herman Fridman
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
    Irina Larionova, Elena Kazakova, Marina Patysheva, Julia Kzhyshkowska
    Cancers.2020; 12(6): 1411.     CrossRef
Original Article
Epidemiology
Longitudinal Changes of Body Composition Phenotypes and Their Association with Incident Type 2 Diabetes Mellitus during a 5-Year Follow-up in Koreans
Hong-Kyu Kim, Min Jung Lee, Eun-Hee Kim, Sung-Jin Bae, Jaewon Choe, Chul-Hee Kim, Joong-Yeol Park
Diabetes Metab J. 2019;43(5):627-639.   Published online April 19, 2019
DOI: https://doi.org/10.4093/dmj.2018.0141
  • 5,043 View
  • 65 Download
  • 19 Web of Science
  • 19 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

To elucidate longitudinal changes of complex body composition phenotypes and their association with incident type 2 diabetes mellitus.

Methods

A total of 17,280 (mean age, 48.1±8.2 years) Korean adults who underwent medical check-ups were included. The mean follow-up duration was 5.5±0.5 years. Body compositions were assessed using a bioelectrical impedance analysis. Four body composition phenotypes were defined using the median of appendicular skeletal muscle mass (ASM) index and fat mass index: low muscle/low fat (LM/LF); high muscle (HM)/LF; LM/high fat (HF); and HM/HF groups.

Results

Of the individuals in the LM/LF or HM/HF groups, over 60% remained in the same group, and over 30% were moved to the LM/HF group. Most of the LM/HF group remained in this group. In the baseline HM/LF group, approximately 30% stayed in the group, and the remaining individuals transitioned to the three other groups in similar proportions. Incident diabetes was significantly lower in participants who remained in the HM/LF group than those who transitioned to the LM/LF or LM/HF group from the baseline HM/LF group in men. ASM index was significantly associated with a decreased risk for incident diabetes in men regardless of obesity status (adjusted odds ratio [OR], 0.71 per kg/m2; 95% confidence interval [CI], 0.52 to 0.97 in non-obese) (adjusted OR, 0.87; 95% CI, 0.77 to 0.98 in obese) after adjusting for other strong risk factors (e.g., baseline glycosylated hemoglobin and homeostasis model assessment of insulin resistance).

Conclusion

Maintenance of ASM may be protective against the development of type 2 diabetes mellitus in men, regardless of obesity status.

Citations

Citations to this article as recorded by  
  • Metabolically healthy obese individuals are still at high risk for diabetes: Application of the marginal structural model
    Hye Ah Lee, Hyesook Park
    Diabetes, Obesity and Metabolism.2024; 26(2): 431.     CrossRef
  • Association of serum gamma-glutamyl transferase with myosteatosis assessed by muscle quality mapping using abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Clinical Imaging.2023; 93: 4.     CrossRef
  • More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study
    Melanie S. Haines, Aaron Leong, Bianca C. Porneala, Victor W. Zhong, Cora E. Lewis, Pamela J. Schreiner, Karen K. Miller, James B. Meigs, Mercedes R. Carnethon
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 105.     CrossRef
  • Association between hypertension and myosteatosis evaluated by abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Hypertension Research.2023; 46(4): 845.     CrossRef
  • Longitudinal association between adiposity changes and lung function deterioration
    Youngmok Park, Jiyoung Kim, Young Sam Kim, Ah Young Leem, Jinyeon Jo, Kyungsoo Chung, Moo Suk Park, Sungho Won, Ji Ye Jung
    Respiratory Research.2023;[Epub]     CrossRef
  • Relevance of body composition in phenotyping the obesities
    Laura Salmón-Gómez, Victoria Catalán, Gema Frühbeck, Javier Gómez-Ambrosi
    Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 809.     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Association between type 2 diabetes and skeletal muscle quality assessed by abdominal computed tomography scan
    Eun Hee Kim, Hong‐Kyu Kim, Min Jung Lee, Sung‐Jin Bae, Kyung Won Kim, Jaewon Choe
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study
    Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hoz
    Journal of Diabetes Investigation.2022; 13(5): 858.     CrossRef
  • Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults
    Jee Hee Yoo, Sung Woon Park, Ji Eun Jun, Sang‐Man Jin, Kyu Yeon Hur, Moon‐Kyu Lee, Mira Kang, Gyuri Kim, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • Reference Data and T-Scores of Lumbar Skeletal Muscle Area and Its Skeletal Muscle Indices Measured by CT Scan in a Healthy Korean Population
    Eun Hee Kim, Kyung Won Kim, Yongbin Shin, Jiwoo Lee, Yousun Ko, Ye-Jee Kim, Min Jung Lee, Sung-Jin Bae, Sung Won Park, Jaewon Choe, Hong-Kyu Kim, Anne Newman
    The Journals of Gerontology: Series A.2021; 76(2): 265.     CrossRef
  • Age- and Sex-Related Differential Associations between Body Composition and Diabetes Mellitus
    Eun Roh, Soon Young Hwang, Jung A Kim, You-Bin Lee, So-hyeon Hong, Nam Hoon Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Diabetes & Metabolism Journal.2021; 45(2): 183.     CrossRef
  • Cardiometabolic Profile of Different Body Composition Phenotypes in Children
    Yi Ying Ong, Jonathan Y Huang, Navin Michael, Suresh Anand Sadananthan, Wen Lun Yuan, Ling-Wei Chen, Neerja Karnani, S Sendhil Velan, Marielle V Fortier, Kok Hian Tan, Peter D Gluckman, Fabian Yap, Yap-Seng Chong, Keith M Godfrey, Mary F-F Chong, Shiao-Yn
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(5): e2015.     CrossRef
  • Age-related changes in muscle quality and development of diagnostic cutoff points for myosteatosis in lumbar skeletal muscles measured by CT scan
    Hong-Kyu Kim, Kyung Won Kim, Eun Hee Kim, Min Jung Lee, Sung-Jin Bae, Yousun Ko, Taeyoung Park, Yongbin Shin, Ye-Jee Kim, Jaewon Choe
    Clinical Nutrition.2021; 40(6): 4022.     CrossRef
  • Comparison of muscle mass and quality between metabolically healthy and unhealthy phenotypes
    Hong‐Kyu Kim, Min Jung Lee, Eun Hee Kim, Sung‐Jin Bae, Kyung Won Kim, Chul‐Hee Kim
    Obesity.2021; 29(8): 1375.     CrossRef
  • Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity
    Melanie S. Haines, Laura E. Dichtel, Kate Santoso, Martin Torriani, Karen K. Miller, Miriam A. Bredella
    International Journal of Obesity.2020; 44(9): 1851.     CrossRef
  • Impact of Social Jetlag on Weight Change in Adults: Korean National Health and Nutrition Examination Survey 2016–2017
    Jin Hwa Kim, Young Sang Lyu, Sang Yong Kim
    International Journal of Environmental Research and Public Health.2020; 17(12): 4383.     CrossRef
  • The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes
    Ailsa A. Welch, Richard P. G. Hayhoe, Donnie Cameron
    Proceedings of the Nutrition Society.2020; 79(1): 158.     CrossRef
  • Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Jung A Kim, Da Hye Kim, Seon Mee Kim, Yong Gyu Park, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyungdo Han, Hye Jin Yoo
    Endocrinology and Metabolism.2019; 34(4): 406.     CrossRef
Brief Report
Complication
Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Diabetes Metab J. 2018;42(2):169-172.   Published online March 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.169
  • 3,382 View
  • 43 Download
AbstractAbstract PDFPubReader   

Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9.5 (PGP 9.5) for whole autonomic nerves was performed. The quantity of immunostained portion of SP, PSP, and PGP 9.5 stained nerve fibers showed decreased trend in diabetic group; however, the ratio of SP/PSP of adipose tissue was higher in diabetic group compared with control group as follows (0.70±0.30 vs. 0.95±0.25, P<0.05; normal vs. diabetic, respectively). Both SP and PSP nerve fibers were observed in white adipose tissue and PSP nerve fibers were suggested as more decreased in diabetes based on our observation.


Diabetes Metab J : Diabetes & Metabolism Journal