Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
5 "Glucose metabolism"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Metabolic Risk/Epidemiology
Glucose Effectiveness from Short Insulin-Modified IVGTT and Its Application to the Study of Women with Previous Gestational Diabetes Mellitus
Micaela Morettini, Carlo Castriota, Christian Göbl, Alexandra Kautzky-Willer, Giovanni Pacini, Laura Burattini, Andrea Tura
Diabetes Metab J. 2020;44(2):286-294.   Published online January 13, 2020
DOI: https://doi.org/10.4093/dmj.2019.0016
  • 5,232 View
  • 82 Download
  • 4 Web of Science
  • 3 Crossref
AbstractAbstract PDFPubReader   
Background

This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGDM).

Methods

CSG was designed using the stepwise model selection approach on a population of subjects (n=181) ranging from normal tolerance to type 2 diabetes mellitus (T2DM). CSG was then tested on a population of women with pGDM (n=57). Each subject underwent a 3-hour IM-IVGTT; women with pGDM were observed early postpartum and after a follow-up period of up to 7 years and classified as progressors (PROG) or non-progressors (NONPROG) to T2DM. The minimal model analysis provided a reference SG.

Results

CSG was described as CSG=1.06×10−2+5.71×10−2×KG/Gpeak, KG being the mean slope (absolute value) of loge glucose in 10–25- and 25–50-minute intervals, and Gpeak being the maximum of the glucose curve. Good agreement between CSG and SG in the general population and in the pGDM group, both at baseline and follow-up (even in PROG and NONPROG subgroups), was shown by the Bland-Altman plots (<5% observations outside limits of agreement), and by the test for equivalence (equivalence margin not higher than one standard deviation). At baseline, the PROG subgroup showed significantly lower SG and CSG values compared to the NONPROG subgroup (P<0.03).

Conclusion

CSG is a valid SG predictor. In the pGDM group, glucose effectiveness appeared to be impaired in women progressing to T2DM.

Citations

Citations to this article as recorded by  
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • Unraveling the Factors Determining Development of Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus Through Machine-Learning Techniques
    Ludovica Ilari, Agnese Piersanti, Christian Göbl, Laura Burattini, Alexandra Kautzky-Willer, Andrea Tura, Micaela Morettini
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
Clinical Diabetes & Therapeutics
Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction?
Veronica Falcone, Grammata Kotzaeridi, Melanie Hanne Breil, Ingo Rosicky, Tina Stopp, Gülen Yerlikaya-Schatten, Michael Feichtinger, Wolfgang Eppel, Peter Husslein, Andrea Tura, Christian S. Göbl
Diabetes Metab J. 2019;43(6):785-793.   Published online March 12, 2019
DOI: https://doi.org/10.4093/dmj.2018.0218
  • 8,408 View
  • 80 Download
  • 20 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   
Background

An early identification of the risk groups might be beneficial in reducing morbidities in patients with gestational diabetes mellitus (GDM). Therefore, this study aimed to assess the biochemical predictors of glycemic conditions, in addition to fasting indices of glucose disposal, to predict the development of GDM in later stage and the need of glucose-lowering medication.

Methods

A total of 574 pregnant females (103 with GDM and 471 with normal glucose tolerance [NGT]) were included. A metabolic characterization was performed before 15+6 weeks of gestation by assessing fasting plasma glucose (FPG), fasting insulin (FI), fasting C-peptide (FCP), and glycosylated hemoglobin (HbA1c). Thereafter, the patients were followed-up until the delivery.

Results

Females with NGT had lower levels of FPG, FI, FCP, or HbA1c at the early stage of pregnancy, and therefore, showed an improved insulin action as compared to that in females who developed GDM. Higher fasting levels of FPG and FCP were associated with a higher risk of developing GDM. Moreover, the predictive accuracy of this metabolic profiling was also good to distinguish the patients who required glucose-lowering medications. Indices of glucose disposal based on C-peptide improved the predictive accuracy compared to that based on insulin. A modified quantitative insulin sensitivity check index (QUICKIc) showed the best differentiation in terms of predicting GDM (area under the receiver operating characteristics curve [ROC-AUC], 72.1%) or need for pharmacotherapy (ROC-AUC, 83.7%).

Conclusion

Fasting measurements of glucose and C-peptide as well as the surrogate indices of glycemic condition could be used for stratifying pregnant females with higher risk of GDM at the beginning of pregnancy.

Citations

Citations to this article as recorded by  
  • Maternal fasting serum C-peptide concentrations in the first and second trimesters and subsequent risk of gestational diabetes mellitus: A nested case-control study among Chinese women
    Chuanyu Zhao, Haiyan Liu, Yuzhi Deng, Hanbin Wu, Shuo Wang, Xinyi Lyu, Jueming Lei, Haishan Yang, Meina Hu, Yinzhu Zhao, Xu Ma, Xiaoxuan Zou, Ying Yang
    Diabetes Research and Clinical Practice.2024; 208: 111111.     CrossRef
  • Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes
    Charalampos Milionis, Ioannis Ilias, Anastasia Lekkou, Evangelia Venaki, Eftychia Koukkou
    World Journal of Experimental Medicine.2024;[Epub]     CrossRef
  • Early prediction of gestational diabetes mellitus using maternal demographic and clinical risk factors
    Yanqi Wu, Paul Hamelmann, Myrthe van der Ven, Sima Asvadi, M. Beatrijs van der Hout-van der Jagt, S. Guid Oei, Massimo Mischi, Jan Bergmans, Xi Long
    BMC Research Notes.2024;[Epub]     CrossRef
  • First-trimester fasting plasma glucose as a predictor of subsequent gestational diabetes mellitus and adverse fetomaternal outcomes: A systematic review and meta-analysis
    Saptarshi Bhattacharya, Lakshmi Nagendra, Deep Dutta, Sunetra Mondal, Sowrabha Bhat, John Michael Raj, Hiya Boro, A.B.M. Kamrul-Hasan, Sanjay Kalra
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(6): 103051.     CrossRef
  • Gestationsdiabetes (GDM) (Update 2023)
    Alexandra Kautzky-Willer, Yvonne Winhofer, Herbert Kiss, Veronica Falcone, Angelika Berger, Monika Lechleitner, Raimund Weitgasser, Jürgen Harreiter
    Wiener klinische Wochenschrift.2023; 135(S1): 115.     CrossRef
  • MIDO GDM: an innovative artificial intelligence-based prediction model for the development of gestational diabetes in Mexican women
    Héctor Gallardo-Rincón, María Jesús Ríos-Blancas, Janinne Ortega-Montiel, Alejandra Montoya, Luis Alberto Martinez-Juarez, Julieta Lomelín-Gascón, Rodrigo Saucedo-Martínez, Ricardo Mújica-Rosales, Victoria Galicia-Hernández, Linda Morales-Juárez, Lucía Ma
    Scientific Reports.2023;[Epub]     CrossRef
  • Progress in the Prediction of Gestational Diabetes Mellitus by the Combined Detection of Fasting Blood Glucose and Hemoglobin in Early Pregnancy
    欢欢 赵
    Advances in Clinical Medicine.2023; 13(06): 9980.     CrossRef
  • HOMA‐IR as a risk factor of gestational diabetes mellitus and a novel simple surrogate index in early pregnancy
    Shuoning Song, Yuemei Zhang, Xiaolin Qiao, Yanbei Duo, Jiyu Xu, Zhenyao Peng, Jing Zhang, Yan Chen, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Zechun Lu, Shixuan Liu, Tianyi Zhao, Tao Yuan, Yong Fu, Yingyue Dong, Weigang Zhao, Wei Sun, Ailing Wang
    International Journal of Gynecology & Obstetrics.2022; 157(3): 694.     CrossRef
  • The diagnostic value of glycosylated hemoglobin for gestational diabetes mellitus in Asian populations: A systematic review and meta‐analysis
    Jiani Zhang, Fan Zhou, Tingting Xu, Jinfeng Xu, Yaqian Li, Li Lin, Qi Cao, Xiaodong Wang
    Journal of Obstetrics and Gynaecology Research.2022; 48(4): 902.     CrossRef
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • Gestational Diabetes Mellitus in Pregnant Women with Beta-Thalassemia Minor: A Matched Case-Control Study
    Veronica Falcone, Florian Heinzl, Bianca Karla Itariu, Theresa Reischer, Stephanie Springer, Dana Anaïs Muin, Petra Pateisky, Philipp Foessleitner, Johannes Ott, Alex Farr, Klara Rosta
    Journal of Clinical Medicine.2022; 11(7): 2050.     CrossRef
  • Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta‐analysis
    Nahal Habibi, Aya Mousa, Chau Thien Tay, Mahnaz Bahri Khomami, Rhiannon K. Patten, Prabha H. Andraweera, Molla Wassie, Jared Vandersluys, Ali Aflatounian, Tina Bianco‐Miotto, Shao J. Zhou, Jessica A. Grieger
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus
    Tina Linder, Anna Eder, Cécile Monod, Ingo Rosicky, Daniel Eppel, Katharina Redling, Franziska Geissler, Evelyn A. Huhn, Irene Hösli, Christian S. Göbl
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Identification of potential gene markers in gestational diabetes mellitus
    Weichun Tang, Xiaoyu Wang, Liping Chen, Yiling Lu, Xinyi Kang
    Journal of Clinical Laboratory Analysis.2022;[Epub]     CrossRef
  • Association between early-pregnancy serum C-peptide and risk of gestational diabetes mellitus: a nested case–control study among Chinese women
    Xue Yang, Yi Ye, Yi Wang, Ping Wu, Qi Lu, Yan Liu, Jiaying Yuan, Xingyue Song, Shijiao Yan, Xiaorong Qi, Yi-Xin Wang, Ying Wen, Gang Liu, Chuanzhu Lv, Chun-Xia Yang, An Pan, Jianli Zhang, Xiong-Fei Pan
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • Early Predictors of Gestational Diabetes Mellitus in IVF-Conceived Pregnancies
    Ayla Coussa, Hayder A. Hasan, Thomas M. Barber
    Endocrine Practice.2021; 27(6): 579.     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
  • Early Gestational Diabetes Mellitus: Diagnostic Strategies and Clinical Implications
    Saptarshi Bhattacharya, Lakshmi Nagendra, Aishwarya Krishnamurthy, Om J. Lakhani, Nitin Kapoor, Bharti Kalra, Sanjay Kalra
    Medical Sciences.2021; 9(4): 59.     CrossRef
  • Early markers of gestational diabetes mellitus
    Vedrana Ivić, Jasenka Wagner, Andrijana Müller, Lada Zibar, Marta Kadivnik, Barbara Viljetić, Jelena Omazić
    Biochemia medica.2021; 31(3): 416.     CrossRef
  • Response: Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction? (Diabetes Metab J 2019;43:785–93)
    Christian S. Göbl, Andrea Tura
    Diabetes & Metabolism Journal.2020; 44(1): 209.     CrossRef
  • First-trimester fasting glycemia as a predictor of gestational diabetes (GDM) and adverse pregnancy outcomes
    G. Sesmilo, P. Prats, S. Garcia, I. Rodríguez, A. Rodríguez-Melcón, I. Berges, B. Serra
    Acta Diabetologica.2020; 57(6): 697.     CrossRef
  • Letter: Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction? (Diabetes Metab J 2019;43:785–93)
    Ye Seul Yang, Hye Seung Jung
    Diabetes & Metabolism Journal.2020; 44(1): 199.     CrossRef
  • Auch schon im 1. Trimenon ist Nüchternglukose Prädiktor für Gestationsdiabetes
    Jens Stupin
    Info Diabetologie.2020; 14(2): 14.     CrossRef
  • Comparison of Machine Learning Methods and Conventional Logistic Regressions for Predicting Gestational Diabetes Using Routine Clinical Data: A Retrospective Cohort Study
    Yunzhen Ye, Yu Xiong, Qiongjie Zhou, Jiangnan Wu, Xiaotian Li, Xirong Xiao
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Predictive Power of Unconjugated Estriol in Diagnosis of Gestational Diabetes: A Cohort Study
    Azam Amirian, Nourossadat Kariman, Mehdi Hedayati, Nasrin Borumandnia, Zohre Sheikhan
    Iranian Red Crescent Medical Journal.2019;[Epub]     CrossRef
Reviews
Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
Nam Ho Jeoung
Diabetes Metab J. 2015;39(3):188-197.   Published online June 15, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.3.188
  • 6,561 View
  • 140 Download
  • 101 Web of Science
  • 95 Crossref
AbstractAbstract PDFPubReader   

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to acetyl-CoA. Tight control of PDC is critical because it plays a key role in glucose disposal. PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns, kinetic properties, and sensitivities to regulatory molecules. During the last decades, the up-regulation of PDKs has been observed in the tissues of patients and mammals with metabolic diseases, which suggests that the inhibition of these kinases may have beneficial effects for treating metabolic diseases. This review summarizes the recent advances in the role of specific PDK isoenzymes on the induction of metabolic diseases and describes the effects of PDK inhibition on the prevention of metabolic diseases using pharmacological inhibitors. Based on these reports, PDK isoenzymes are strong therapeutic targets for preventing and treating metabolic diseases.

Citations

Citations to this article as recorded by  
  • Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
    Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu
    The Journal of Infectious Diseases.2024; 229(4): 1178.     CrossRef
  • Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria
    Konstantin S. Plokhikh, Semen V. Nesterov, Yuriy M. Chesnokov, Anton G. Rogov, Roman A. Kamyshinsky, Aleksandr L. Vasiliev, Lev S. Yaguzhinsky, Raif G. Vasilov
    The FEBS Journal.2024; 291(1): 132.     CrossRef
  • Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
    Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha
    International Journal of Molecular Sciences.2024; 25(2): 807.     CrossRef
  • Gamut of glycolytic enzymes in vascular smooth muscle cell proliferation: Implications for vascular proliferative diseases
    Ankan Sarkar, Sandip V. Pawar, Kanwaljit Chopra, Manish Jain
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(3): 167021.     CrossRef
  • Recent advances in pyruvate dehydrogenase kinase inhibitors: Structures, inhibitory mechanisms and biological activities
    Yiyang Li, Zhizhong Xie, Xiaoyong Lei, Xiaoyan Yang, Sheng Huang, Weixi Yuan, Xiangping Deng, Zhe Wang, Guotao Tang
    Bioorganic Chemistry.2024; 144: 107160.     CrossRef
  • Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments
    Jianda Yue, Jiawei Xu, Yekui Yin, Yuanyuan Shu, Yaqi Li, Tingting Li, Zirui Zou, Zihan Wang, Fengjiao Li, Mengqi Zhang, Songping Liang, Xiao He, Zhonghua Liu, Ying Wang
    International Journal of Biological Macromolecules.2024; 262: 129970.     CrossRef
  • Metabolic regulation of skeletal cell fate and function
    Steve Stegen, Geert Carmeliet
    Nature Reviews Endocrinology.2024; 20(7): 399.     CrossRef
  • Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer
    Wonyoung Park, Shibo Wei, Chu-Long Xie, Jung Ho Han, Bo-Sung Kim, Bosung Kim, Jung-Sook Jin, Eun-Sun Yang, Min Kyoung Cho, Dongryeol Ryu, Hao-Xian Yang, Sung-Jin Bae, Ki-Tae Ha
    Experimental & Molecular Medicine.2024; 56(5): 1137.     CrossRef
  • Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase
    Masafumi Inoue, Hironobu Nagamori, Toru Morita, Satoru Kobayashi, Koichi Suzawa, Yuki Kitao, Tomoyuki Saito, Iichiro Kawahara, Takuya Orita, Shota Akai, Tsuyoshi Adachi, Takahisa Motomura
    Bioorganic & Medicinal Chemistry Letters.2024; 109: 129839.     CrossRef
  • Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
    Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
    Diabetes & Metabolism Journal.2024; 48(3): 405.     CrossRef
  • Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads
    Yuejiao Wang, Xue Wang, Chaoqi Du, Zeming Wang, Jiahui Wang, Nan Zhou, Baohua Wang, Ke Tan, Yumei Fan, Pengxiu Cao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Research into how carvacrol and metformin affect several human proteins in a hyperglycemic condition: A comparative study in silico and in vitro
    Nail Besli, Nilufer Ercin, Miguel Carmena-Bargueño, Bahar Sarikamis, Rabia Kalkan Cakmak, Guven Yenmis, Horacio Pérez-Sánchez, Merve Beker, Ulkan Kilic
    Archives of Biochemistry and Biophysics.2024; 758: 110062.     CrossRef
  • Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
    Hui-fang Zhang, Hui-ming Liu, Jia-yi Xiang, Xing-cheng Zhou, Dan Wang, Rong-yu Chen, Wan-lin Tan, Lu-qun Liang, Ling-ling Liu, Ming-jun Shi, Fan Zhang, Ying Xiao, Yu-xia Zhou, Tian Zhang, Lei Tang, Bing Guo, Yuan-yuan Wang
    Acta Pharmacologica Sinica.2023; 44(5): 1051.     CrossRef
  • Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer
    Weijing He, Qingguo Li, Xinxiang Li
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(1): 188837.     CrossRef
  • Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3
    Kehinde S. Olaniyi, Stephanie E. Areloegbe
    Nutrition.2023; 107: 111914.     CrossRef
  • Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines
    Lijun Gong, Fang Wei, Frank J. Gonzalez, Guolin Li
    Hepatology.2023; 78(5): 1625.     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors
    Deniz Arslan, Matthieu Schoumacher, Sébastien Dilly, Benaïssa Elmoualij, Danièle Zorzi, Pascale Quatresooz, Vincent Lambert, Agnès Noël, Bernard Pirotte, Pascal de Tullio
    Medicinal Chemistry.2023; 19(3): 276.     CrossRef
  • AP2α negatively regulates PDHA1 in cervical cancer cells to promote aggressive features and aerobic glycolysis in vitro and in vivo
    Lijie Zhao, Rong Geng, Yi Huang, Jiping Zhang, Haiying Cheng, Cankun Zhou, Yifeng Wang
    Journal of Gynecologic Oncology.2023;[Epub]     CrossRef
  • Pyruvate dehydrogenase kinase inhibitor dichloroacetate augments autophagy mediated constraining the replication of Mycobacteroides massiliense in macrophages
    Hailian Quan, Hyewon Chung, Sungmo Je, Jung Joo Hong, Bum-Joon Kim, Yi Rang Na, Seung Hyeok Seok
    Microbes and Infection.2023; 25(7): 105139.     CrossRef
  • Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
    Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan
    Blood Advances.2023; 7(11): 2347.     CrossRef
  • Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue
    Zhi-Hong Wen, Chun-Sung Sung, Sung-Chun Lin, Zhi-Kang Yao, Yu-Cheng Lai, Yu-Wei Liu, Yu-Yan Wu, Hsi-Wen Sun, Hsin-Tzu Liu, Wu-Fu Chen, Yen-Hsuan Jean
    International Journal of Molecular Sciences.2023; 24(13): 10770.     CrossRef
  • TUG1 protects against ferroptosis of hepatic stellate cells by upregulating PDK4-mediated glycolysis
    Xiangting Zhang, Luying Zhao, Kanglei Ying, Jun Xu, Yangjin Huang, Ruhuang Zhu, Yinrong Ding, Weimin Cai, Xiao Wu, Dan Miao, Qian Xu, Yuan Zeng, Fujun Yu
    Chemico-Biological Interactions.2023; 383: 110673.     CrossRef
  • Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
    Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
    Chenyu Li, Chuanbin Liu, Junfeng Zhang, Yanyu Lu, Bingtong Jiang, Huabao Xiong, Chunxia Li
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Implications of tempol in pyruvate dehydrogenase kinase 3 targeted anticancer therapeutics: Computational, spectroscopic, and calorimetric studies
    Saleha Anwar, Debarati DasGupta, Alaa Shafie, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Moyad Shahwan, Farah Anjum, Waleed Al Abdulmonem, Sharaf E. Sharaf, Md. Imtaiyaz Hassan
    Journal of Molecular Liquids.2022; 350: 118581.     CrossRef
  • Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect
    Mohamed A. Nassan, Adil Aldhahrani, Hamada H. Amer, Ahmed Elhenawy, Ayman A. Swelum, Omar M. Ali, Yasser H. Zaki
    Molecules.2022; 27(3): 756.     CrossRef
  • An enzyme-responsive and NIR-triggered lipid–polymer hybrid nanoplatform for synergistic photothermal/chemo cancer therapy
    Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
    Biomaterials Science.2022; 10(9): 2370.     CrossRef
  • BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway
    Huashun Li, Dongyang Yu, Lianbing Li, Juanjuan Xiao, Yijian Zhu, Yi Liu, Li Mou, Yafei Tian, Linbo Chen, Feng Zhu, Qiuhong Duan, Peipei Xue, Dali Zheng
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
    Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
    Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
  • Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs
    Fereydoon Abedi-Gaballu, Elham Kamal Kazemi, Seyed Ahmad Salehzadeh, Behnaz Mansoori, Farhad Eslami, Ali Emami, Gholamreza Dehghan, Behzad Baradaran, Behzad Mansoori, William C. Cho
    Cells.2022; 11(19): 2973.     CrossRef
  • PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level
    Yan Song, Juan Zhang, Lei Zhang, Suxia Zhang, Chengcheng Shen, Jincheng Wang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Changes in the Expression of Pyruvate Dehydrogenase Kinase Isoenzymes During Early Differentiation of Mouse Embryonic Stem Cells
    Saime GÜZEL
    Journal of Research in Veterinary Medicine.2022; 41(2): 92.     CrossRef
  • Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation
    Sunil Poudel, Gil Martins, M. Leonor Cancela, Paulo J. Gavaia
    International Journal of Molecular Sciences.2022; 23(23): 15160.     CrossRef
  • Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer
    Taj Mohammad, Kaynat Arif, Mohamed F. Alajmi, Afzal Hussain, Asimul Islam, Md. Tabish Rehman, Imtaiyaz Hassan
    Journal of Biomolecular Structure and Dynamics.2021; 39(2): 586.     CrossRef
  • Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
    Russel J. Reiter, Ramaswamy Sharma, Sergio Rosales-Corral
    International Journal of Molecular Sciences.2021; 22(2): 764.     CrossRef
  • BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
    Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
    Developmental Cell.2021; 56(8): 1182.     CrossRef
  • Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
    Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li
    Bioscience Reports.2021;[Epub]     CrossRef
  • Identification of differentially expressed genes and the role of PDK4 in CD14+ monocytes of coronary artery disease
    Pei Du, Ren Guo, Keqin Gao, Shuang Yang, Baige Yao, Haobo Cui, Ming Zhao, Sujie Jia
    Bioscience Reports.2021;[Epub]     CrossRef
  • Radiation-Induced Metabolic Shifts in the Hepatic Parenchyma: Findings from 18F-FDG PET Imaging and Tissue NMR Metabolomics in a Mouse Model for Hepatocellular Carcinoma
    Yi-Hsiu Chung, Cheng-Kun Tsai, Ching-Fang Yu, Wan-Ling Wang, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen, Gigin Lin
    Molecules.2021; 26(9): 2573.     CrossRef
  • Long non-coding RNA AFAP1-AS1 facilitates ovarian cancer progression by regulating the miR-107/PDK4 axis
    Bao Liu, Li Yan, Yugang Chi, Yuhan Sun, Xiaoyu Yang
    Journal of Ovarian Research.2021;[Epub]     CrossRef
  • Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
    Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568.     CrossRef
  • Metabolic Alterations in Sepsis
    Weronika Wasyluk, Agnieszka Zwolak
    Journal of Clinical Medicine.2021; 10(11): 2412.     CrossRef
  • Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex
    Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao, Chenji Wang
    Cell Death & Disease.2021;[Epub]     CrossRef
  • circ_0005962 functions as an oncogene to aggravate NSCLC progression
    Zhihong Zhang, Zhenxiu Shan, Rubin Chen, Xiaorong Peng, Bin Xu, Liang Xiao, Guofei Zhang
    Open Medicine.2021; 16(1): 997.     CrossRef
  • Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways
    Yu Liu, Yan-Qing Li, Shi-Hao Huang, Yong-Long Li, Jia-Wei Xia, Jun-Shuang Jia, Fang Wei, Jia-Hong Wang, Guan-Qi Dai, Yu-Cai Wang, Xiao-Yan Li, Liu-Xin Han, Xiao-Ling Zhang, Xu-Dong Xiang, Wen-Tao Zhao, Dong Xiao, Xiao-Lin Lin
    Aging.2021; 13(17): 21155.     CrossRef
  • Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis
    Yihong Huang, Shuo Zheng, Ying Lin, Liming Ke
    Molecular and Cellular Biology.2021;[Epub]     CrossRef
  • Odontogenic gene expression profile of human dental pulp-derived cells under high glucose influence: a microarray analysis
    Sivaporn HORSOPHONPHONG, Hathaitip SRITANAUDOMCHAI, Siriruk NAKORNCHAI, Nakarin KITKUMTHORN, Rudee SURARIT
    Journal of Applied Oral Science.2021;[Epub]     CrossRef
  • Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
    I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva
    Cellular and Molecular Life Sciences.2021; 78(23): 7451.     CrossRef
  • Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells
    Ling Jin, Minkyoung Cho, Bo-Sung Kim, Jung Ho Han, Sungmi Park, In-Kyu Lee, Dongryeol Ryu, Jae Ho Kim, Sung-Jin Bae, Ki-Tae Ha
    BMB Reports.2021; 54(11): 563.     CrossRef
  • Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area
    Giovanni Tulipano
    International Journal of Molecular Sciences.2021; 22(23): 13068.     CrossRef
  • Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
    Choong-Hwan Kwak, Ling Jin, Jung Ho Han, Chang Woo Han, Eonmi Kim, MyoungLae Cho, Tae-Wook Chung, Sung-Jin Bae, Se Bok Jang, Ki-Tae Ha
    International Journal of Molecular Sciences.2020; 21(17): 6021.     CrossRef
  • Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy
    Chung-Yu Huang, Li-Han Hsu, Chung-Yeh Chen, Gee-Chen Chang, Hui-Wen Chang, Yi-Mei Hung, Ko-Jiunn Liu, Shu-Huei Kao
    Cancers.2020; 12(1): 181.     CrossRef
  • Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
    Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • STAT 3 ‐dependent analysis reveals PDK 4 as independent predictor of recurrence in prostate cancer
    Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger, Jan Pencik, Petra Kodajova, Sandra Högler, Georg Stockmaier, Sandra Grund‐Gröschk
    Molecular Systems Biology.2020;[Epub]     CrossRef
  • Differential effects of metformin on reductive activity and energy production in pituitary tumor cells compared to myogenic precursors
    Giovanni Tulipano, Simone Paghera, Cristina Missale, Andrea Giustina
    Endocrine.2020; 69(3): 604.     CrossRef
  • Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
    Xiqiong Han, Wenqi Ma, Yi Zhu, Xuejiao Sun, Naifeng Liu
    Molecular and Cellular Endocrinology.2020; 514: 110878.     CrossRef
  • Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells
    Giovanni Tulipano, Andrea Giustina
    Pituitary.2020; 23(3): 223.     CrossRef
  • Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
    Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
    Cancer & Metabolism.2020;[Epub]     CrossRef
  • miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer
    Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li
    Molecular Therapy - Oncolytics.2020; 17: 509.     CrossRef
  • Bayesian variable selection for high dimensional predictors and self-reported outcomes
    Xiangdong Gu, Mahlet G Tadesse, Andrea S Foulkes, Yunsheng Ma, Raji Balasubramanian
    BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
  • Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?
    Jordy M. M. Kocken, Paula A. da Costa Martins
    International Journal of Molecular Sciences.2020; 21(23): 8901.     CrossRef
  • Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
    Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha
    Scientific Reports.2020;[Epub]     CrossRef
  • Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
    Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Ri
    eLife.2019;[Epub]     CrossRef
  • Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
    Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
    Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
  • Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
    Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo
    European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells
    Rokibul Islam, Jae-Gyu Kim, Yohan Park, Jung-Yoon Cho, Kim-Cuong Cap, A-Ra Kho, Won-Suk Chung, Sang-Won Suh, Jae-Bong Park
    The FASEB Journal.2019; 33(2): 2072.     CrossRef
  • ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts
    Tatsufumi Goto, Kumi Ubukawa, Isuzu Kobayashi, Kotomi Sugawara, Ken Asanuma, Yumi Sasaki, Yong-Mei Guo, Naoto Takahashi, Kenichi Sawada, Hideki Wakui, Wataru Nunomura
    Experimental Hematology.2019; 72: 14.     CrossRef
  • Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity
    Choong-Hwan Kwak, Jung-Hee Lee, Eun-Yeong Kim, Chang Woo Han, Keuk-Jun Kim, Hanna Lee, MyoungLae Cho, Se Bok Jang, Cheorl-Ho Kim, Tae-Wook Chung, Ki-Tae Ha
    Cancers.2019; 11(5): 712.     CrossRef
  • Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server
    Andreia S.P. Pereira, Helena den Haan, Jorge Peña-García, Marién M. Moreno, Horacio Pérez-Sánchez, Zeno Apostolides
    Molecules.2019; 24(10): 2002.     CrossRef
  • Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
    Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez, Zeno Apostolides
    Molecules.2019; 24(22): 4030.     CrossRef
  • Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
    Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
    Cells.2019; 8(11): 1449.     CrossRef
  • Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
    Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
    Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
  • Molecular interactions underpinning the phenotype of hibernation in mammals
    Matthew T. Andrews
    Journal of Experimental Biology.2019;[Epub]     CrossRef
  • Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma
    Surangkana Sanmai, Tanakorn Proungvitaya, Temduang Limpaiboon, Daraporn Chua‑On, Wunchana Seubwai, Sittiruk Roytrakul, Sopit Wongkham, Chaisiri Wongkham, Ongart Somintara, Sakkarn Sangkhamanon, Siriporn Proungvitaya
    Oncology Letters.2019;[Epub]     CrossRef
  • Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells
    Li Xie, Junqing Miao, Xiangchao Li, Xiaoping Yi, Ju Chu
    RSC Advances.2019; 9(61): 35760.     CrossRef
  • Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
    F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
    Oncogene.2018; 37(8): 1062.     CrossRef
  • Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
    Lise Van Wyngene, Jolien Vandewalle, Claude Libert
    EMBO Molecular Medicine.2018;[Epub]     CrossRef
  • Effects of β-caryophyllene on arginine ADP-ribosyltransferase 1-mediated regulation of glycolysis in colorectal cancer under high-glucose conditions
    Li Zhou, Mu-Lu Zhan, Yi Tang, Ming Xiao, Ming Li, Qing-Shu Li, Lian Yang, Xian Li, Wen-Wen Chen, Ya-Lan Wang
    International Journal of Oncology.2018;[Epub]     CrossRef
  • PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
    Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
    Diabetes.2018; 67(10): 2054.     CrossRef
  • Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer
    Bojana Ristic, Yangzom D. Bhutia, Vadivel Ganapathy
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(1): 246.     CrossRef
  • Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
    Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
    Oncotarget.2017; 8(68): 112841.     CrossRef
  • Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth
    Tae-Wook Chung, Jung Hee Lee, Hee-Jung Choi, Mi-Ju Park, Eun-Yeong Kim, Jung Ho Han, Se Bok Jang, Syng-Ook Lee, Sang Woo Lee, Jin Hang, Li Wan Yi, Ki-Tae Ha
    Journal of Ethnopharmacology.2017; 203: 47.     CrossRef
  • Spatial Organization of Metabolic Enzyme Complexes in Cells
    Danielle L. Schmitt, Songon An
    Biochemistry.2017; 56(25): 3184.     CrossRef
  • Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells
    Wenjia Zhang, Jing Su, Huadan Xu, Shanshan Yu, Yanan Liu, Yong Zhang, Liankun Sun, Ying Yue, Xiaoli Zhou, Aamir Ahmad
    PLOS ONE.2017; 12(6): e0179672.     CrossRef
  • Metabonomic Strategy for the Evaluation of Chinese Medicine Salvia miltiorrhiza and Dalbergia odorifera Interfering with Myocardial Ischemia/Reperfusion Injury in Rats
    Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
    Rejuvenation Research.2017; 20(4): 263.     CrossRef
  • Regulation of pyruvate dehydrogenase (PDH) in the hibernating ground squirrel, ( Ictidomys tridecemlineatus )
    Sanoji Wijenayake, Shannon N. Tessier, Kenneth B. Storey
    Journal of Thermal Biology.2017; 69: 199.     CrossRef
  • Nuclear localization of metabolic enzymes in immunity and metastasis
    Yuchen He, Menghui Gao, Yiqu Cao, Haosheng Tang, Shuang Liu, Yongguang Tao
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(2): 359.     CrossRef
  • The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism
    Ewa Jablonska, Edyta Reszka, Jolanta Gromadzinska, Edyta Wieczorek, Magdalena Krol, Sara Raimondi, Katarzyna Socha, Maria Borawska, Wojciech Wasowicz
    Nutrients.2016; 8(12): 772.     CrossRef
  • Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
    Jaechan Leem, In-Kyu Lee
    Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
  • Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
    Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
    Scientific Reports.2016;[Epub]     CrossRef
  • Drugs that Affect Cardiac Metabolism: Focus on Perhexiline
    Cher-Rin Chong, Benedetta Sallustio, John D. Horowitz
    Cardiovascular Drugs and Therapy.2016; 30(4): 399.     CrossRef
  • Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
    Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
    International Journal of Molecular Sciences.2016; 17(3): 340.     CrossRef
  • Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
    Camille Lehuédé, Fanny Dupuy, Rebecca Rabinovitch, Russell G. Jones, Peter M. Siegel
    Cancer Research.2016; 76(18): 5201.     CrossRef
Obstructive Sleep Apnea and Abnormal Glucose Metabolism
Nan Hee Kim
Diabetes Metab J. 2012;36(4):268-272.   Published online August 20, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.4.268
  • 3,530 View
  • 36 Download
  • 16 Crossref
AbstractAbstract PDFPubReader   

Obstructive sleep apnea (OSA) is a chronic disorder that is prevalent, especially in subjects with obesity or diabetes. OSA is related to several metabolic abnormalities, including diabetes, insulin resistance, hypertension, and cardiovascular diseases. Although Koreans are less obese than Caucasians, the prevalence of OSA is comparable in both groups. Thus, the impact of OSA on metabolism may be similar. Many epidemiologic and experimental studies have demonstrated that OSA is associated with glucose intolerance and insulin resistance via intermittent hypoxia, sleep fragmentation, and sleep deprivation. The effect of continuous positive airway pressure treatment on glucose metabolism is still controversial. Randomized controlled trials are needed to evaluate the ability of OSA treatment to reduce the risk of diabetes and insulin resistance in subjects without diabetes and to ameliorate glucose control in patients with diabetes.

Citations

Citations to this article as recorded by  
  • One-month of a low-energy diet, with no additional effect of high-protein, reduces Obstructive Sleep Apnea severity and improve metabolic parameters in obese males
    Camila Maria de Melo, Marcus Vinicius Lúcio dos Santos Quaresma, Mariana Pantaleão del Re, Sandra Maria Lima Ribeiro, Hanna Karen Moreira Antunes, Sonia M. Togeiro, Sergio Tufik, Marco Túlio de Mello
    Clinical Nutrition ESPEN.2021; 42: 82.     CrossRef
  • Noncontact Sleep Monitoring With Infrared Video Data to Estimate Sleep Apnea Severity and Distinguish Between Positional and Nonpositional Sleep Apnea: Model Development and Experimental Validation
    Sina Akbarian, Nasim Montazeri Ghahjaverestan, Azadeh Yadollahi, Babak Taati
    Journal of Medical Internet Research.2021; 23(11): e26524.     CrossRef
  • Distinguishing Obstructive Versus Central Apneas in Infrared Video of Sleep Using Deep Learning: Validation Study
    Sina Akbarian, Nasim Montazeri Ghahjaverestan, Azadeh Yadollahi, Babak Taati
    Journal of Medical Internet Research.2020; 22(5): e17252.     CrossRef
  • A study of glycemic variability in patients with type 2 diabetes mellitus with obstructive sleep apnea syndrome using a continuous glucose monitoring system
    Suhas S. Khaire, Jugal V. Gada, Ketaki V. Utpat, Nikita Shah, Premlata K. Varthakavi, Nikhil M. Bhagwat
    Clinical Diabetes and Endocrinology.2020;[Epub]     CrossRef
  • Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?
    Alessio Pecori, Fabrizio Buffolo, Jacopo Pieroni, Vittorio Forestiero, Elisa Sconfienza, Franco Veglio, Paolo Mulatero, Silvia Monticone
    Hormone and Metabolic Research.2020; 52(06): 366.     CrossRef
  • Automated Non-Contact Detection of Head and Body Positions During Sleep
    Sina Akbarian, Ghazaleh Delfi, Kaiyin Zhu, Azadeh Yadollahi, Babak Taati
    IEEE Access.2019; 7: 72826.     CrossRef
  • Habitual late sleep initiation is associated with increased incidence of type 2 diabetes mellitus in Korean adults: the Korean Genome and Epidemiology Study
    Ji A Seo, Da Young Lee, Ji Hee Yu, Hyunjoo Cho, Seung Ku Lee, Sooyeon Suh, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
    Sleep.2019;[Epub]     CrossRef
  • Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression
    Tetiana V Serebrovska, Alla G Portnychenko, Tetiana I Drevytska, Vladimir I Portnichenko, Lei Xi, Egor Egorov, Anna V Gavalko, Svitlana Naskalova, Valentina Chizhova, Valeriy B Shatylo
    Experimental Biology and Medicine.2017; 242(15): 1542.     CrossRef
  • Features of continuous glycemic profile and glycemic variability in patients with obstructive sleep apnea syndrome
    Chao-Sheng Peng, Yue-An Cao, Yu-Hong Tian, Wen-Luo Zhang, Jing Xia, Lu Yang
    Diabetes Research and Clinical Practice.2017; 134: 106.     CrossRef
  • Acute Hypoxic Test in Patients with Prediabetes
    Valerii B. Shatylo, Tatiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, Oleg V. Korkushko
    High Altitude Medicine & Biology.2016; 17(2): 101.     CrossRef
  • Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat
    Ji Hee Yu, Jae Hee Ahn, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin, Nan Hee Kim
    The Korean Journal of Internal Medicine.2015; 30(6): 846.     CrossRef
  • Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome
    Natalya Viktorovna Strueva, Galina Afanas'evna Melnichenko, Mikhail Gur'evich Poluektov, Larisa Viktorovna Savel'eva, Gulinara Viktorovna Katsya, Nikolay Petrovich Goncharov
    Obesity and metabolism.2015; 12(2): 24.     CrossRef
  • Obstructive sleep apnea, hypertension and cardiovascular diseases
    C Gonzaga, A Bertolami, M Bertolami, C Amodeo, D Calhoun
    Journal of Human Hypertension.2015; 29(12): 705.     CrossRef
  • Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure
    Elena Olea, Maria Teresa Agapito, Teresa Gallego-Martin, Asuncion Rocher, Angela Gomez-Niño, Ana Obeso, Constancio Gonzalez, Sara Yubero
    Journal of Applied Physiology.2014; 117(7): 706.     CrossRef
  • Effect of Continuous Positive Airway Pressure on Type 2 Diabetes Mellitus and Glucose Metabolism
    Lucy Gallegos, Tejal Dharia, Annette B. Gadegbeku
    Hospital Practice.2014; 42(2): 31.     CrossRef
  • Association of Obstructive Sleep Apnea and Glucose Metabolism in Subjects With or Without Obesity
    Nan Hee Kim, Nam H. Cho, Chang-Ho Yun, Seung Ku Lee, Dae Wui Yoon, Hyun Joo Cho, Jae Hee Ahn, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin
    Diabetes Care.2013; 36(12): 3909.     CrossRef
Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
Christos S. Mantzoros
Diabetes Metab J. 2012;36(3):181-189.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.181
  • 3,002 View
  • 28 Download
  • 18 Crossref
AbstractAbstract PDFPubReader   

Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, have low leptin levels. In the context of open-label, uncontrolled studies leptin administration, in physiological replacement doses, has been shown to have metabolically salutary effects in the rare patients with the syndrome of congenital lipodystrophy accompanied by leptin deficiency. Much more patients with lipodystrophy suffer from lipodystrophy and the metabolic syndrome associated with the use of highly active antiretroviral therapy. In this so called highly active antiretroviral therapy (HAART)-associated lipodystrophy and metabolic syndrome, patients demonstrate fat maldistribution with dyslipidemia, insulin resistance, and other metabolic complications. Leptin administration has been shown to decrease central fat mass and to improve fasting insulin/glucose levels and insulin sensitivity in human immunodeficiency virus-infected hypoleptinemic patients with HAART induced lipodystrophy and the metabolic syndrome. By contrast, the results of leptin treatment in leptin replete or hyperleptinemic obese individuals with glucose intolerance and diabetes mellitus have been minimal or null, presumably due to leptin tolerance or resistance that impairs leptin action. In this review, we present the emerging clinical applications and potential therapeutic uses of leptin in humans with lipodystrophy and the metabolic syndrome.

Citations

Citations to this article as recorded by  
  • Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery
    Michail Kokkorakis, Angeliki Katsarou, Niki Katsiki, Christos S. Mantzoros
    Metabolism.2023; 148: 155689.     CrossRef
  • The common pathophysiologic threads between Asian Indian diabetic’s ‘Thin Fat Phenotype’ and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences
    Aditya Saxena, Pradeep Tiwari, Nitin Wahi, Anshul Kumar, Sandeep Kumar Mathur
    Adipocyte.2020; 9(1): 253.     CrossRef
  • The effect of underweight on female and male reproduction
    Chrysoula Boutari, Panagiotis D. Pappas, Gesthimani Mintziori, Meletios P. Nigdelis, Loukas Athanasiadis, Dimitrios G. Goulis, Christos S. Mantzoros
    Metabolism.2020; 107: 154229.     CrossRef
  • Clinical presentations, metabolic abnormalities and end-organ complications in patients with familial partial lipodystrophy
    Baris Akinci, Huseyin Onay, Tevfik Demir, Şenay Savas-Erdeve, Ramazan Gen, Ilgin Yildirim Simsir, Fatma Ela Keskin, Mehmet Sercan Erturk, Ayse Kubat Uzum, Guzin Fidan Yaylali, Nilufer Kutbay Ozdemir, Tahir Atik, Samim Ozen, Banu Sarer Yurekli, Tugce Apayd
    Metabolism.2017; 72: 109.     CrossRef
  • CURRENT STATE OF THE PROBLEM OF OVERWEIGHT AND OBESITY IN WOMEN
    L. V. Tkachenko, N. I. Sviridova, T. V. Skladanovskaya
    Journal of Volgograd State Medical University.2017; 14(4): 3.     CrossRef
  • Leptin and Hormones
    Georgios A. Triantafyllou, Stavroula A. Paschou, Christos S. Mantzoros
    Endocrinology and Metabolism Clinics of North America.2016; 45(3): 633.     CrossRef
  • An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lepob/Lepob mouse
    Vinay Bhaskar, Ira D. Goldfine, Resi Gerstner, Kristen Michelson, Catarina Tran, Genevieve Nonet, David Bohmann, Elizabeth Pongo, Jingsong Zhao, Arnold H. Horwitz, Toshihiko Takeuchi, Mark White, John A. Corbin
    Obesity.2016; 24(8): 1687.     CrossRef
  • Lipodystrophic Diabetes Mellitus: a Lesson for Other Forms of Diabetes?
    Romina Ficarella, Luigi Laviola, Francesco Giorgino
    Current Diabetes Reports.2015;[Epub]     CrossRef
  • Aldehyde Dehydrogenase 1A1: Friend or Foe to Female Metabolism?
    Jennifer Petrosino, David DiSilvestro, Ouliana Ziouzenkova
    Nutrients.2014; 6(3): 950.     CrossRef
  • Comparative endocrinology of leptin: Assessing function in a phylogenetic context
    Richard L. Londraville, Yazmin Macotela, Robert J. Duff, Marietta R. Easterling, Qin Liu, Erica J. Crespi
    General and Comparative Endocrinology.2014; 203: 146.     CrossRef
  • Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge
    J.A. Paniagua, J.M. Escandell-Morales, D. Gil-Contreras, F.J. Berral de la Rosa, M. Romero-Jimenez, A. Gómez-Urbano, A. Sanchez-Lopez, E. Bellido, A. Poyato, B. Calatayud, A.J. Vidal-Puig
    Nutrition.2014; 30(2): 177.     CrossRef
  • The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review
    Konstantinos Michalakis, Gesthimani Mintziori, Athina Kaprara, Basil C. Tarlatzis, Dimitrios G. Goulis
    Metabolism.2013; 62(4): 457.     CrossRef
  • Dietary supplementation with long-chain monounsaturated fatty acids attenuates obesity-related metabolic dysfunction and increases expression of PPAR gamma in adipose tissue in type 2 diabetic KK-Ay mice
    Zhi-Hong Yang, Hiroko Miyahara, Yusuke Iwasaki, Jiro Takeo, Masashi Katayama
    Nutrition & Metabolism.2013; 10(1): 16.     CrossRef
  • Embryo-transfer of the F2 postnatal calorie restricted female rat offspring into a control intra-uterine environment normalizes the metabolic phenotype
    Meena Garg, Manikkavasagar Thamotharan, Yun Dai, Paul W.N. Lee, Sherin U. Devaskar
    Metabolism.2013; 62(3): 432.     CrossRef
  • Obesity in the ageing man
    K. Michalakis, D.G. Goulis, A. Vazaiou, G. Mintziori, A. Polymeris, A. Abrahamian-Michalakis
    Metabolism.2013; 62(10): 1341.     CrossRef
  • Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index
    Yusuf Ozkan, Esra Suay Timurkan, Suleyman Aydin, İbrahim Sahin, Mustafa Timurkan, Cihan Citil, Mehmet Kalayci, Musa Yilmaz, Aziz Aksoy, Zekiye Catak
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome
    Maria Dalamaga, Konstantinos Karmaniolas, John Chamberland, Athina Nikolaidou, Antigoni Lekka, Amalia Dionyssiou-Asteriou, Christos S. Mantzoros
    Metabolism.2013; 62(12): 1830.     CrossRef
  • Metabolische Korrektur mit Leptin
    Konstanze Miehle, Michael Stumvoll, Mathias Fasshauer, Wieland Kiess, Thomas Kapellen
    Info Diabetologie.2012; 6(5): 37.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer