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Original Article
- Dietary Oleate Has Beneficial Effects on Every Step of Non-Alcoholic Fatty Liver Disease Progression in a Methionine- and Choline-Deficient Diet-Fed Animal Model
- Ji Young Lee, Jae Hoon Moon, Jong Suk Park, Byung-Wan Lee, Eun Seok Kang, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha
- Diabetes Metab J. 2011;35(5):489-496. Published online October 31, 2011
- DOI: https://doi.org/10.4093/dmj.2011.35.5.489
- 30,904 View
- 45 Download
- 17 Crossref
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Abstract
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PubReader Background Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the development and progression of NAFLD in a methionine- and choline-deficient (MCD) diet-fed animal model.
Methods A total of 30 C57BL/6J mice were randomly divided into three groups (
n =10 in each group) and fed various experimental diets for four weeks: chow, MCD diet, or OMCD (MCD diet with oleate, 0.5 mg/g/day). Liver samples were examined for steatohepatitis and fibrosis parameters and associated genes.Results Additional dietary oleate dramatically reduced MCD diet-induced hepatic steatosis. Hepatic carbohydrate responsive element-binding protein was overexpressed in MCD diet-fed mice, and dietary oleate prevented this overexpression (
P <0.001). Dietary oleate partially prevented MCD diet-induced serum level increases in aspartate aminotransferase and alanine aminotransferase (P <0.001, respectively). The mRNA expressions of hepatic monocyte chemoattractant protein 1, tumor necrosis factor-α and matrix metalloproteinase-9 were increased in MCD diet-fed mice, and this overexpression of inflammatory molecules was prevented by dietary oleate (P <0.001). Hepatic pericellular fibrosis was observed in MCD diet-fed mice, and dietary oleate prevented this fibrosis. Altogether, dietary oleate prevented MCD diet-induced hepatic steatosis, inflammation and fibrosis.Conclusion Dietary oleate has beneficial effects in every step of NAFLD development and progression and could be a nutritional option for NAFLD prevention and treatment.
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Citations
Citations to this article as recorded by
- Bidirectional association between NAFLD and gallstone disease: a systematic review and meta-analysis of observational studies
Shengying Gu, Shanshan Hu, Shuowen Wang, Chendong Qi, Chenyang Shi, Guorong Fan
Expert Review of Gastroenterology & Hepatology.2023; 17(3): 283. CrossRef - The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease
Camelia Munteanu, Betty Schwartz
Antioxidants.2023; 12(4): 903. CrossRef - Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease
Anja Hess, Stefan D Gentile, Amel Ben Saad, Raza‐Ur Rahman, Tim Habboub, Daniel S Pratt, Alan C Mullen
The EMBO Journal.2023;[Epub] CrossRef - Histopathological Examination of the Effects of Tocilizumab and Dexamethasone on the Liver in Rats of Oleic Acid induced Acute Lung Injury
Funda TERZİ, Hüseyin Serkan EROL
Balıkesır Health Sciences Journal.2022;[Epub] CrossRef - Identifying Lipid Metabolites Influenced by Oleic Acid Administration Using High-Performance Liquid Chromatography–Mass Spectrometry-Based Lipidomics
Chao Xu, Dan Song, Askild L. Holck, Youyou Zhou, Rong Liu
ACS Omega.2020; 5(20): 11314. CrossRef - Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders
P. Vineeth Daniel, Prosenjit Mondal
European Journal of Cell Biology.2020; 99(8): 151128. CrossRef - PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
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Cell Death & Disease.2019;[Epub] CrossRef - Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels
Jianzhong Ye, Longxian Lv, Wenrui Wu, Yating Li, Ding Shi, Daiqiong Fang, Feifei Guo, Huiyong Jiang, Ren Yan, Wanchun Ye, Lanjuan Li
Frontiers in Microbiology.2018;[Epub] CrossRef - Olive oil combined with Lycium barbarum polysaccharides attenuates liver apoptosis and inflammation induced by carbon tetrachloride in rats
Yun-Yun Chiang, Jane C.-J. Chao
Journal of Functional Foods.2018; 48: 329. CrossRef - Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Marion Régnier, Alice Marmugi, Fadila Benhamed, Justine Bertrand-Michel, Laila Mselli-Lakhal, Nicolas Loiseau, Pascal G. Martin, Jean-Marc Lobaccaro, Laurent Ferrier, Catherine Postic,
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Simon Ducheix, Maria Carmela Vegliante, Gaetano Villani, Nicola Napoli, Carlo Sabbà, Antonio Moschetta
Cellular and Molecular Life Sciences.2016; 73(20): 3809. CrossRef - Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
Young Mi Song, Yong-ho Lee, Ji-Won Kim, Dong-Sik Ham, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee
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Sanja Stojsavljević
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Emily B. Button, Andrew S. Mitchell, Marcia M. Domingos, Jessica H.‐J. Chung, Ryan M. Bradley, Ashkan Hashemi, Phillip M. Marvyn, Ashley C. Patterson, Ken D. Stark, Joe Quadrilatero, Robin E. Duncan
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World Journal of Hepatology.2013; 5(10): 558. CrossRef - Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction
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Autophagy.2012; 8(7): 1085. CrossRef
- Bidirectional association between NAFLD and gallstone disease: a systematic review and meta-analysis of observational studies
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