Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Previous issues

Page Path
HOME > Browse > Previous issues
11 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 37(1); February 2013
Prev issue Next issue
Reviews
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
Hayley M. O'Neill
Diabetes Metab J. 2013;37(1):1-21.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.1
  • 8,889 View
  • 146 Download
  • 180 Crossref
AbstractAbstract PDFPubReader   

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).

Citations

Citations to this article as recorded by  
  • Molecular mechanisms underlying sarcopenia in heart failure
    Cody A. Rutledge
    The Journal of Cardiovascular Aging.2024;[Epub]     CrossRef
  • Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation
    Yuying Li, Pengjun Shi, Kang Yao, Qian Lin, Mansheng Wang, Zhenping Hou, Wenjie Tang, Hui Diao
    Animal Nutrition.2024; 16: 299.     CrossRef
  • Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
    Abduldaheem Turki Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, Muna S. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy
    Indian Journal of Clinical Biochemistry.2024;[Epub]     CrossRef
  • Small peptides: could they have a big role in metabolism and the response to exercise?
    Muhammed M. Atakan, İbrahim Türkel, Berkay Özerkliğ, Şükran N. Koşar, Dale F. Taylor, Xu Yan, David J. Bishop
    The Journal of Physiology.2024; 602(4): 545.     CrossRef
  • The genetic and dietary landscape of the muscle insulin signalling network
    Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
    eLife.2024;[Epub]     CrossRef
  • Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation
    Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
    Redox Biology.2024; 70: 103079.     CrossRef
  • The genetic and dietary landscape of the muscle insulin signalling network
    Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
    eLife.2024;[Epub]     CrossRef
  • AMPK activation modulates IL‐36‐induced inflammatory responses by regulating IκBζ expression in the skin
    Yi‐Ting Huang, Ling‐Ya Chiu, Po‐Hsuan Lu, Pa‐Fan Hsiao, Jen‐Yu Wang, Ping‐Hsun Lu, Nan‐Lin Wu
    British Journal of Pharmacology.2024;[Epub]     CrossRef
  • Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
    Manar Mohammed El Tabaa, Maram Mohammed El Tabaa, Eman Rashad, Mohammed Salah Elballal, Ola Elazazy
    International Immunopharmacology.2024; 132: 111954.     CrossRef
  • Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions
    Xingsheng Jin, Yang Chen, Bingxiang Xu, Haili Tian
    Biology.2024; 13(4): 247.     CrossRef
  • Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study
    Daiahun Thabah, Donkupar Syiem, Careen Liza Pakyntein, Sagnik Banerjee, Cynthia Erica Kharshiing, Atanu Bhattacharjee
    Archives of Physiology and Biochemistry.2023; 129(5): 1071.     CrossRef
  • The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review
    Eren Canbolat, Funda Pınar Cakıroglu
    Critical Reviews in Food Science and Nutrition.2023; 63(4): 449.     CrossRef
  • Hydrogen Sulfide Regulates Glucose Uptake in Skeletal Muscles via S-Sulfhydration of AMPK in Muscle Fiber Type-Dependent Way
    Kelin Li, Minghui Wang, Ruxia Wang, Xiaojuan Wang, Hongchao Jiao, Jingpeng Zhao, Yunlei Zhou, Haifang Li, Hai Lin
    The Journal of Nutrition.2023; 153(10): 2878.     CrossRef
  • Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
    Ishitha Reddy, Yamini Yadav, Chinmoy Sankar Dey
    Cellular and Molecular Neurobiology.2023; 43(4): 1551.     CrossRef
  • Gene expression profile analysis unravelled the systems level association of renal cell carcinoma with diabetic nephropathy and Matrix-metalloproteinase-9 as a potential therapeutic target
    Aditya Rao, Pavan Gollapalli, Nandini Prasad Shetty
    Journal of Biomolecular Structure and Dynamics.2023; 41(16): 7535.     CrossRef
  • Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
    Ha-Thanh-Tung Pham, Eun-Jin Park, Byeol Ryu, Hee-Ju Lee, Thi-Phuong Doan, Hyo-Moon Cho, Thi-Linh-Giang Pham, Won-Keun Oh
    Phytochemistry.2023; 205: 113513.     CrossRef
  • The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB–mediated inflammatory response
    Jingjing Liu, Jiao Lu, Liumei Zhang, Yuting Liu, Yuan Zhang, Yaran Gao, Xinmeng Yuan, Mengqi Xiang, Qiang Tang
    Biomedicine & Pharmacotherapy.2023; 157: 114080.     CrossRef
  • Recent advances in sea cucumber peptide: Production, bioactive properties, and prospects
    Jiacong Man, A. M. Abd El‐Aty, Zuzhe Wang, Mingqian Tan
    Food Frontiers.2023; 4(1): 131.     CrossRef
  • Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide
    Soo Yue Yin, Siddiqua Ayesha, Chellasamy Panneerselvam, Adel Ibrahim Alalawy, Fahad Mohamed Almutairi, Mohamed Ali Seyed
    Drugs and Drug Candidates.2023; 2(1): 52.     CrossRef
  • Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review
    Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou, Baoan Chen
    Biomolecules.2023; 13(2): 250.     CrossRef
  • The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
    Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
    Nutrients.2023; 15(7): 1660.     CrossRef
  • Modulation of GPC-4 and GPLD1 serum levels by improving glycemic indices in type 2 diabetes: Resistance training and hawthorn extract intervention
    Ali Heidarianpour, Maryam Keshvari, Siamak Shahidi, Mohammad Zarei
    Heliyon.2023; 9(4): e15537.     CrossRef
  • Oral administration of wild plant‐derived minerals and red ginseng ameliorates insulin resistance in fish through different pathways
    Kiyomi Takase, Izuru Kakuta
    Physiological Reports.2023;[Epub]     CrossRef
  • Anti‐fatigue properties of the ethanol extract of Moringa oleifera leaves in mice
    Xiangyu Bian, Yawen Wang, Renren Yang, Yuying Ma, Weiyun Dong, Changjiang Guo, Weina Gao
    Journal of the Science of Food and Agriculture.2023; 103(11): 5500.     CrossRef
  • AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis
    Ankita Sharma, Sumit Kr Anand, Neha Singh, Upendra Nath Dwivedi, Poonam Kakkar
    Experimental Cell Research.2023; 428(1): 113614.     CrossRef
  • Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells
    Caizhu Wang, Ruqin Lin, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng, Jikai Wen
    Biochemical Pharmacology.2023; 214: 115645.     CrossRef
  • Gαi‐coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals
    Do‐Hyung Lee, Kyung‐Sun Heo, Chang‐Seon Myung
    Obesity.2023; 31(7): 1871.     CrossRef
  • Sapogeninas de Chenopodium quinoa Willd como activadores potenciales de AMPKβ2 para la homeostasis independiente de insulina
    Ricardo Enrique Grados Torrez, Dayana Pamela Bello- Kopa, Ricardo Enrique Grados-Torrez
    Gaceta Médica Boliviana.2023; 46(1): 6.     CrossRef
  • Potential mechanisms of multimodal prehabilitation effects on surgical complications: a narrative review
    Daniel Sibley, Maggie Chen, Malcolm A West, Andrew G Matthew, Daniel Santa Mina, Ian Randall
    Applied Physiology, Nutrition, and Metabolism.2023; 48(9): 639.     CrossRef
  • Insights into the molecular mechanism of muscle textural quality improvement treated by exercise using comparative transcriptome analysis on the hybrid (Erythroculter ilishaeformis ♀ × Ancherythroculter nigrocauda ♂)
    Lang Zhang, Huijie Wei, Yali Yu, Qing Li, Ziwei Song, Yanhong Sun, Pei Li, Jian Chen, Jinhua Gan, Hui Zhang, Xiaorong Lu, Guiying Wang, Li He
    Aquaculture Reports.2023; 31: 101672.     CrossRef
  • Risks and benefits of salicylates in food: a narrative review
    Joanna Suliburska, Rafsan Syabani Cholik
    Nutrition Reviews.2023;[Epub]     CrossRef
  • Nrf2 modulates the benefits of evening exercise in type 2 diabetes
    Babatunde Fasipe, Ismail Laher
    Sports Medicine and Health Science.2023; 5(4): 251.     CrossRef
  • Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-related Quality of Life in Middle-aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
    Jinghua Zhang, Wilson Wai San Tam, Kanokwan Hounsri, Joji Kusuyama, Vivien Xi Wu
    Archives of Physical Medicine and Rehabilitation.2023;[Epub]     CrossRef
  • Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats
    Douglas Lopes Almeida, Gabriel Sergio Fabricio, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Camila Cristina Ianoni Matiusso, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Audrei Pavanello, Ananda Malta, Kesia Palma-Rigo, Paulo Cezar de F
    Journal of Developmental Origins of Health and Disease.2022; 13(3): 406.     CrossRef
  • Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function
    Xue Wang, Yu-ting Zhu, Yi Zhu, Yan-ling Sun, Jun Huang, Zhe Li, Yan Wang, Jun-chao Wu, Zheng-hong Qin, Fang Lin
    Acta Pharmacologica Sinica.2022; 43(4): 850.     CrossRef
  • The Molecular Signature of High-intensity Training in the Human Body
    Patrick Wahl, Wilhelm Bloch, Sebastian Proschinger
    International Journal of Sports Medicine.2022; 43(03): 195.     CrossRef
  • Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin
    Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang, Yen Wei
    Materials Chemistry Frontiers.2022; 6(2): 128.     CrossRef
  • Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
    Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisic
    International Journal of Molecular Sciences.2022; 23(1): 548.     CrossRef
  • Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats
    Zakiah N. Almohawes, Attalla El-Kott, Kareem Morsy, Ali A. Shati, Ayman E. El-Kenawy, Heba S. Khalifa, Fahmy G. Elsaid, Abd-El-Karim M. Abd-Lateif, Ahmed Abu-Zaiton, Eman R. Ebealy, Mohamed M. Abdel-Daim, Reham A. Ghanem, Eman M. Abd-Ella
    Archives of Physiology and Biochemistry.2022; : 1.     CrossRef
  • The Effect of Various Training on the Expression of the 5’amp-Activated Protein Kinase Α2 and Glucose Transporter - 4 in Type-2 Diabetes Mellitus Rat
    Rahmi Rahmi, Yetty Machrina, Zulham Yamamoto
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1.     CrossRef
  • Avian Orexin: Feed Intake Regulator or Something Else?
    Alison Ramser, Sami Dridi
    Veterinary Sciences.2022; 9(3): 112.     CrossRef
  • Luteolin Synergistically Enhances Antitumor Activity of Oxaliplatin in Colorectal Carcinoma via AMPK Inhibition
    Chan Ho Jang, Nayoung Moon, Jinkyung Lee, Min Jeong Kwon, Jisun Oh, Jong-Sang Kim
    Antioxidants.2022; 11(4): 626.     CrossRef
  • Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity
    Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition
    Jinsoo Kim, Jinyoung Son, Dohee Ahn, Gibeom Nam, Xiaodi Zhao, Hyuna Park, Woojoo Jeong, Sang J. Chung
    International Journal of Molecular Sciences.2022; 23(7): 3927.     CrossRef
  • Effect of Long-Term Supplementation with Acetic Acid on the Skeletal Muscle of Aging Sprague Dawley Rats
    Hitomi Maruta, Reina Abe, Hiromi Yamashita
    International Journal of Molecular Sciences.2022; 23(9): 4691.     CrossRef
  • AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway
    Vishal Kothari, Jeganathan Ramesh Babu, Suresh T. Mathews, Regis Moreau
    PLOS ONE.2022; 17(5): e0266472.     CrossRef
  • Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling
    Md Badrul Alam, Jeong‐Sic Ra, Ji‐Young Lim, Bo‐Rim Song, Ahsan Javed, Sang‐Han Lee
    Molecular Nutrition & Food Research.2022;[Epub]     CrossRef
  • Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
    Tara McDonnell, Leanne Cussen, Marie McIlroy, Michael W. O’Reilly
    Therapeutic Advances in Endocrinology and Metabolism.2022; 13: 204201882211131.     CrossRef
  • Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats
    Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu
    Food Science and Human Wellness.2022; 11(6): 1614.     CrossRef
  • Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models
    Jing Bai, Shuai Zhang, Jinjing Cao, Hongbin Sun, Zhiguo Mang, Wei L. Shen, Hao Li
    Phytomedicine.2022; 105: 154366.     CrossRef
  • N-Octyl Caffeamide, a Caffeic Acid Amide Derivative, Prevents Progression of Diabetes and Hepatic Steatosis in High-Fat Diet Induced Obese Mice
    Miao-Yi Wu, Chia-Chu Liu, Su-Chu Lee, Yueh-Hsiung Kuo, Tusty-Jiuan Hsieh
    International Journal of Molecular Sciences.2022; 23(16): 8948.     CrossRef
  • The Potential Therapeutic Role of Metformin in Diabetic and Non-Diabetic Bone Impairment
    Wei Mu, Guoqiang Liang, Yue Feng, Yunyun Jiang, Falin Qu
    Pharmaceuticals.2022; 15(10): 1274.     CrossRef
  • Characteristics of the Protocols Used in Electrical Pulse Stimulation of Cultured Cells for Mimicking In Vivo Exercise: A Systematic Review, Meta-Analysis, and Meta-Regression
    Eleni Nintou, Eleni Karligiotou, Maria Vliora, Leonidas G. Ioannou, Andreas D. Flouris
    International Journal of Molecular Sciences.2022; 23(21): 13446.     CrossRef
  • Heliciopsides A−E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake
    Byeol Ryu, Eun-Jin Park, Thi-Phuong Doan, Hyo-Moon Cho, Jin-Pyo An, Thi-Linh-Giang Pham, Ha-Thanh-Tung Pham, Won-Keun Oh
    Pharmaceuticals.2022; 15(11): 1315.     CrossRef
  • Why are physical activity breaks more effective than a single session of isoenergetic exercise in reducing postprandial glucose? A systemic review and meta-analysis
    Hannah Gouldrup, Tongyu Ma
    Journal of Sports Sciences.2021; 39(2): 212.     CrossRef
  • TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation
    Hee-Seon Park, Ji-Won Song, Jin-Ho Park, Byung-Kwan Lim, Og-Sung Moon, Hwa-Young Son, Jae-Hyuk Lee, Bin Gao, Young-Suk Won, Hyo-Jung Kwon
    Autophagy.2021; 17(9): 2549.     CrossRef
  • Dissecting the molecular pathways involved in the effects of physical activity on breast cancers cells: A narrative review
    Francesca Maria Orlandella, Anna Elisa De Stefano, Paola Lucia Chiara Iervolino, Pasqualina Buono, Andrea Soricelli, Giuliana Salvatore
    Life Sciences.2021; 265: 118790.     CrossRef
  • In silico study to quantify the effect of exercise on surface GLUT4 translocation in diabetes management
    Darshna M. Joshi, Jignesh Patel, Hardik Bhatt
    Network Modeling Analysis in Health Informatics and Bioinformatics.2021;[Epub]     CrossRef
  • Rationale for the use of metformin and exercise to counteract statin‐associated side effects
    Jonida Haxhi, Paul D. Thompson
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats
    Yun Ma, Hitomi Maruta, Baojun Sun, Chengduo Wang, Chiaki Isono, Hiromi Yamashita
    Amino Acids.2021; 53(2): 159.     CrossRef
  • The Effect of Swimming Training and Cinnamon Consumption on the Gene Expression of GLUT4 and Insulin Receptor in the Brown Adipose Tissue of Diabetic Rats
    Mojtaba Karimi Fard, Ali Khajehlandi, Amin Mohammadi
    Gene, Cell and Tissue.2021;[Epub]     CrossRef
  • Antiobesity effect of Brassica juncea cultivated in Jeongseon with optimized sinigrin content using 3T3‐L1 adipocytes
    Hee‐Yeon Kwon, Sun‐Il Choi, Xionggao Han, Xiao Men, Gill‐Woong Jang, Ye‐Eun Choi, Ok‐Hwan Lee
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel
    Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li
    Food & Function.2021; 12(9): 4221.     CrossRef
  • Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle
    Ji H. Kang, Ji E. Park, Jason Dagoon, Stewart W. C. Masson, Troy L. Merry, Shannon N. Bremner, Jessica R. Dent, Simon Schenk
    Journal of Applied Physiology.2021; 130(6): 1893.     CrossRef
  • TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells
    Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
    Cells.2021; 10(6): 1560.     CrossRef
  • Effects of exercise on cellular and tissue aging
    Priscila Viana Carapeto, Cristina Aguayo-Mazzucato
    Aging.2021; 13(10): 14522.     CrossRef
  • Biglycan reduces body weight by regulating food intake in mice and improves glucose metabolism through AMPK/AKT dual pathways in skeletal muscle
    InHyeok Chung, Shin Ae Kim, Seolsong Kim, Jung Ok Lee, Clara Yongjoo Park, Juhee Lee, Jun Kang, Jin Young Lee, Ilhyeok Seo, Hye Jeong Lee, Jeong Ah Han, Min Ju Kang, Eunice Lim, Su Jin Kim, Sang Woo Wu, Joo Yeon Oh, Ji Hyung Chung, Eun‐Kyoung Kim, Hyeon S
    The FASEB Journal.2021;[Epub]     CrossRef
  • A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
    Ibrahim Mohammed, Morley D. Hollenberg, Hong Ding, Chris R. Triggle
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever
    Fred J. DiMenna, Avigdor D. Arad
    Cardiovascular Endocrinology & Metabolism.2021; 10(3): 149.     CrossRef
  • Comparative analyses of liver transcriptomes reveal the effect of exercise on growth-, glucose metabolism-, and oxygen transport-related genes and signaling pathways in grass carp (Ctenopharyngodon idella)
    Lang Zhang, Xiaohui Li, Yali Yu, Lin Zhang, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Jie Peng, Li He
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2021; 262: 111081.     CrossRef
  • Effects of moderate exercise on hepatic amino acid and fatty acid composition, liver transcriptome, and intestinal microbiota in channel catfish (Ictalurus punctatus)
    Lang Zhang, Yali Yu, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Xiaohui Li, Li He
    Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.2021; 40: 100921.     CrossRef
  • Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ
    Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K. Leong, Ching-Feng Weng
    Biomedicine & Pharmacotherapy.2021; 144: 112333.     CrossRef
  • The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells
    Lakshi A. Dayarathne, Sachithra S. Ranaweera, Premkumar Natraj, Priyanka Rajan, Young Jae Lee, Chang-Hoon Han
    Journal of Veterinary Science.2021;[Epub]     CrossRef
  • Inhibition of Digestive Enzyme and Stimulation of Human Liver Cells (HepG2) Glucose Uptake by Date Seeds Extract
    Hira Shakoor, Fatima Abdelfattah, Khaula Albadi, Mentalla Adib, Jaleel Kizhakkayil, Carine Platat
    Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1.     CrossRef
  • Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin
    Saman Bahrambeigi, Vahid Shafiei-Irannejad
    Biochemical Pharmacology.2020; 174: 113787.     CrossRef
  • Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
    Sung Sup Park, Young-Kyo Seo
    International Journal of Molecular Sciences.2020; 21(6): 1949.     CrossRef
  • Regulation of podocytes function by AMP-activated protein kinase
    Dorota Rogacka, Irena Audzeyenka, Agnieszka Piwkowska
    Archives of Biochemistry and Biophysics.2020; 692: 108541.     CrossRef
  • AMPK'nin Biyokimyası: Etki Mekanizmaları ve Diyabetin Tedavisindeki Önemi
    Cemalettin KİSMİROĞLU, Serdar CENGİZ, Mustafa YAMAN
    European Journal of Science and Technology.2020; : 162.     CrossRef
  • Potent Inhibitory Effect of BJ-3105, a 6-Alkoxypyridin-3-ol Derivative, on Murine Colitis Is Mediated by Activating AMPK and Inhibiting NOX
    Pallavi Gurung, Sadan Dahal, Prakash Chaudhary, Diwakar Guragain, Ujjwala Karmacharya, Jung-Ae Kim, Byeong-Seon Jeong
    International Journal of Molecular Sciences.2020; 21(9): 3145.     CrossRef
  • Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in skeletal muscle
    Wai-Kin So, Hyoung Kyu Kim, Yingxian Chen, Seung Hun Jeong, Patrick Ka Kit Yeung, Billy C. K. Chow, Jin Han, Sookja K. Chung
    Pflügers Archiv - European Journal of Physiology.2020; 472(2): 195.     CrossRef
  • Metformin ameliorates animal models of dermatitis
    Soo Young Choi, Chanmi Lee, Min-Jeong Heo, Yeong Min Choi, In-sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung
    Inflammopharmacology.2020; 28(5): 1293.     CrossRef
  • Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators
    Junwei Wang, Junhua Liu, Zhifu Xie, Jia Li, Jingya Li, Lihong Hu
    Bioorganic & Medicinal Chemistry Letters.2020; 30(2): 126790.     CrossRef
  • The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
    Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min‐Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin‐Seok Lee, Chang‐Gue Son, Kwon‐Ho Song, Tae Woo Kim, Eun‐Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin R. W. Ngoei, Naomi X. Y. Ling, Jonat
    The FEBS Journal.2020; 287(10): 2087.     CrossRef
  • Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
    Khanyisani Ziqubu, Christo J. F. Muller, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Nnini Obonye, Johan Louw, Abidemi P. Kappo, Sonia Silvestri, Patrick Orlando, Luca Tiano, Sithandiwe E. Mazibuko-Mbeje
    Molecules.2020; 25(8): 1773.     CrossRef
  • Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner
    Dong-Yeon Kim, Su-Geun Lim, Kyoungho Suk, Won-Ha Lee
    Biochemistry and Cell Biology.2020; 98(2): 137.     CrossRef
  • cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells
    Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato
    Journal of Functional Foods.2020; 64: 103632.     CrossRef
  • Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice
    Florian Juszczak, Maud Vlassembrouck, Olivia Botton, Thomas Zwakhals, Morgane Decarnoncle, Alexandra Tassin, Nathalie Caron, Anne-Emilie Declèves
    International Journal of Molecular Sciences.2020; 22(1): 350.     CrossRef
  • The Regulation of Fat Metabolism during Aerobic Exercise
    Antonella Muscella, Erika Stefàno, Paola Lunetti, Loredana Capobianco, Santo Marsigliante
    Biomolecules.2020; 10(12): 1699.     CrossRef
  • Chronic neuromuscular electrical stimulation improves muscle mass and insulin sensitivity in a mouse model
    Adiel Lotri-Koffi, Marion Pauly, Emeline Lemarié, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pépin, Isabelle Vivodtzev
    Scientific Reports.2019;[Epub]     CrossRef
  • Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer
    Kyuwan Lee, Debu Tripathy, Wendy Demark-Wahnefried, Kerry S. Courneya, Nathalie Sami, Leslie Bernstein, Darcy Spicer, Thomas A. Buchanan, Joanne E. Mortimer, Christina M. Dieli-Conwright
    JAMA Oncology.2019; 5(5): 710.     CrossRef
  • Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
    Jiyoung Moon, Min Jin Ha, Min-Jeong Shin, Oh Yoen Kim, Eun Hye Yoo, Juhyun Song, Ji Hyung Chung
    Nutrients.2019; 11(12): 3035.     CrossRef
  • Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes
    Md Badrul Alam, Vivek K. Bajpai, Jeong-Sic Ra, Ji-Young Lim, Hongyan An, Shruti Shukla, Khong Trong Quan, Imran Khan, Yun Suk Huh, Young-Kyu Han, MinKyun Na, Sang-Han Lee
    Food and Chemical Toxicology.2019; 129: 337.     CrossRef
  • AMPKα2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet
    Zhong-Guang SUN, Ge TIAN, Xiao-Ci ZHENG, Wen-Ying LIU, Xue-Ting LUO, Jing XIAO, Hui SONG, Xin XU
    Journal of Nutritional Science and Vitaminology.2019; 65(6): 491.     CrossRef
  • Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals
    Sanghee Park, Kristen D. Turner, Donghai Zheng, Jeffrey J. Brault, Kai Zou, Alec B. Chaves, Thomas S. Nielsen, Charles J. Tanner, Jonas T. Treebak, Joseph A. Houmard
    The Journal of Physiology.2019; 597(2): 449.     CrossRef
  • Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics
    Eric Francelino Andrade, Víviam de Oliveira Silva, Débora Ribeiro Orlando, Luciano José Pereira
    Current Diabetes Reviews.2019; 15(2): 105.     CrossRef
  • Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway
    Nami Kim, Mi Sun Kang, Miso Nam, Shin Ae Kim, Geum-Sook Hwang, Hyeon Soo Kim
    International Journal of Molecular Sciences.2019; 20(19): 4751.     CrossRef
  • Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats
    Jeong Rim Ko, Dae Yun Seo, Tae Nyun Kim, Se Hwan Park, Hyo-Bum Kwak, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
    Journal of Clinical Medicine.2019; 8(5): 666.     CrossRef
  • Metformin; an old antidiabetic drug with new potentials in bone disorders
    Saman Bahrambeigi, Bahman Yousefi, Mahdi Rahimi, Vahid Shafiei-Irannejad
    Biomedicine & Pharmacotherapy.2019; 109: 1593.     CrossRef
  • A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study
    Ritu Varshney, Rutusmita Mishra, Neeladrisingha Das, Debabrata Sircar, Partha Roy
    Journal of Functional Foods.2019; 59: 194.     CrossRef
  • Akt activation: A potential strategy to ameliorate insulin resistance
    Zhengyi Zhang, Huadong Liu, Jiankang Liu
    Diabetes Research and Clinical Practice.2019; 156: 107092.     CrossRef
  • Chitosan encapsulated nanocurcumin induces GLUT-4 translocation and exhibits enhanced anti-hyperglycemic function
    Pratibha Chauhan, Akhilesh Kumar Tamrakar, Sunil Mahajan, G.B.K.S. Prasad
    Life Sciences.2018; 213: 226.     CrossRef
  • Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity
    Victor Castro, Marta Skowronska, Jorge Lombardi, Jane He, Neil Seth, Martina Velichkovska, Michal Toborek
    Journal of Cerebral Blood Flow & Metabolism.2018; 38(2): 317.     CrossRef
  • Interactions between dietary carbohydrate and metformin: Implications on energy sensing, insulin signaling pathway, glycolipid metabolism and glucose tolerance in blunt snout bream Megalobrama amblycephala
    Chao Xu, Wen-Bin Liu, Ding-Dong Zhang, Xiu-Fei Cao, Hua-Juan Shi, Xiang-Fei Li
    Aquaculture.2018; 483: 183.     CrossRef
  • Gossypol from Cottonseeds Ameliorates Glucose Uptake by Mimicking Insulin Signaling and Improves Glucose Homeostasis in Mice with Streptozotocin-Induced Diabetes
    Md Badrul Alam, Hongyan An, Jeong-Sic Ra, Ji-young Lim, Seung-Hyun Lee, Chi-Yeol Yoo, Sang-Han Lee
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
    Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund
    JCI Insight.2018;[Epub]     CrossRef
  • Aerobic exercise training decreases cereblon and increases AMPK signaling in the skeletal muscle of STZ-induced diabetic rats
    Jeong Rim Ko, Dae Yun Seo, Se Hwan Park, Hyo Bum Kwak, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
    Biochemical and Biophysical Research Communications.2018; 501(2): 448.     CrossRef
  • AMPK in skeletal muscle function and metabolism
    Rasmus Kjøbsted, Janne R. Hingst, Joachim Fentz, Marc Foretz, Maria‐Nieves Sanz, Christian Pehmøller, Michael Shum, André Marette, Remi Mounier, Jonas T. Treebak, Jørgen F. P. Wojtaszewski, Benoit Viollet, Louise Lantier
    The FASEB Journal.2018; 32(4): 1741.     CrossRef
  • Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
    Tianyi Wang, Yanmei Niu, Sujuan Liu, Hairui Yuan, Xiaolei Liu, Li Fu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(10): 3368.     CrossRef
  • Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury
    Peng Wang, Lizhu Jiang, Nian Zhou, Hao Zhou, Huzhe Liu, Wenrui Zhao, Hanxiang Zhang, Xiang Zhang, Zhenming Hu
    Oncotarget.2018; 9(9): 8427.     CrossRef
  • Cocoa Flavanol Supplementation and Exercise: A Systematic Review
    Lieselot Decroix, Danusa Dias Soares, Romain Meeusen, Elsa Heyman, Cajsa Tonoli
    Sports Medicine.2018; 48(4): 867.     CrossRef
  • Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes
    Hojun Lee, Wook Song
    Journal of Obesity & Metabolic Syndrome.2018; 27(3): 150.     CrossRef
  • Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice
    Jarinyaporn Naowaboot, Supaporn Wannasiri, Patchareewan Pannangpetch
    Nutrition Research.2018; 56: 51.     CrossRef
  • Cell-Specific “Competition for Calories” Drives Asymmetric Nutrient-Energy Partitioning, Obesity, and Metabolic Diseases in Human and Non-human Animals
    Edward Archer, Gregory Pavela, Samantha McDonald, Carl J. Lavie, James O. Hill
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
    Baile Wang, Kenneth Cheng
    International Journal of Molecular Sciences.2018; 19(11): 3552.     CrossRef
  • Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
    Danqing Feng, Tesfaye Biftu, F. Anthony Romero, Ahmet Kekec, James Dropinski, Andrew Kassick, Shiyao Xu, Marc M. Kurtz, Anantha Gollapudi, Qing Shao, Xiaodong Yang, Ku Lu, Gaochao Zhou, Daniel Kemp, Robert W. Myers, Hong-Ping Guan, Maria E. Trujillo, Cai
    ACS Medicinal Chemistry Letters.2018; 9(1): 39.     CrossRef
  • 2-Bromo-4′-methoxychalcone and 2-Iodo-4′-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5′-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice
    Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu, Tusty-Jiuan Hsieh
    International Journal of Molecular Sciences.2018; 19(9): 2763.     CrossRef
  • Dynamic transcriptomic analysis in hircine longissimus dorsi muscle from fetal to neonatal development stages
    Siyuan Zhan, Wei Zhao, Tianzeng Song, Yao Dong, Jiazhong Guo, Jiaxue Cao, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang
    Functional & Integrative Genomics.2018; 18(1): 43.     CrossRef
  • Oyster mushroom functions as an anti-hyperglycaemic through phosphorylation of AMPK and increased expression of GLUT4 in type 2 diabetic model rats
    Mohammad Asrafuzzaman, Mohammad M. Rahman, Manoj Mandal, Mohammad Marjuque, Amrita Bhowmik, Begum Rokeya, Zahid Hassan, Mohammad Omar Faruque
    Journal of Taibah University Medical Sciences.2018; 13(5): 465.     CrossRef
  • AMP-activated protein kinase α1 in Megalobrama amblycephala: Molecular characterization and the transcriptional modulation by nutrient restriction and glucose and insulin loadings
    Chao Xu, Xiang-Fei Li, Hua-Juan Shi, Jie Liu, Li Zhang, Wen-Bin Liu
    General and Comparative Endocrinology.2018; 267: 66.     CrossRef
  • Comprehensive Relevance of AMPK in Adaptive Responses of Physical Exercise, Skeletal Muscle and Neuromuscular Disorders
    Jun-Ho Lee
    Journal of The Korean Society of Physical Medicine.2018; 13(3): 141.     CrossRef
  • Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism
    Natalie Janzen, Jamie Whitfield, Nolan Hoffman
    International Journal of Molecular Sciences.2018; 19(11): 3344.     CrossRef
  • Exercising with blocked muscle glycogenolysis: Adaptation in the McArdle mouse
    Tue L. Nielsen, Tomàs Pinós, Astrid Brull, John Vissing, Thomas O. Krag
    Molecular Genetics and Metabolism.2018; 123(1): 21.     CrossRef
  • Pharmacological activities of mogrosides
    Can Liu, Longhai Dai, Yueping Liu, Dequan Dou, Yuanxia Sun, Lanqing Ma
    Future Medicinal Chemistry.2018; 10(8): 845.     CrossRef
  • Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4
    Kevin R.W. Ngoei, Christopher G. Langendorf, Naomi X.Y. Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A. Camerino, Scott R. Walker, Ylva E. Bozikis, Toby A. Dite, Ashley J. Ovens, William J. Smiles, Roxane Jacobs, He Huang, Michael W. Parker, John W. Sc
    Cell Chemical Biology.2018; 25(6): 728.     CrossRef
  • Fiber type-specific analysis of AMPK isoforms in human skeletal muscle: advancement in methods via capillary nanoimmunoassay
    Irene S. Tobias, Kara K. Lazauskas, Jose A. Arevalo, James R. Bagley, Lee E. Brown, Andrew J. Galpin
    Journal of Applied Physiology.2018; 124(4): 840.     CrossRef
  • Insulin Mimetic Activity of 3,4-Seco and Hexanordammarane Triterpenoids Isolated from Gynostemma longipes
    Ha Thanh Tung Pham, Thi Kim Quy Ha, Hyo Moon Cho, Ba Wool Lee, Jin Pyo An, Van On Tran, Won Keun Oh
    Journal of Natural Products.2018; 81(11): 2470.     CrossRef
  • Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism
    A.D. Booth, A.M. Magnuson, J. Fouts, Y. Wei, D. Wang, M.J. Pagliassotti, M.T. Foster
    Adipocyte.2018; 7(4): 261.     CrossRef
  • Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase
    Kasandra S. Hunter, Stephen J. Davies
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Neurogenic obesity and systemic inflammation following spinal cord injury: A review
    Gary J. Farkas, David R. Gater
    The Journal of Spinal Cord Medicine.2018; 41(4): 378.     CrossRef
  • In Defense of Sugar: A Critique of Diet-Centrism
    Edward Archer
    Progress in Cardiovascular Diseases.2018; 61(1): 10.     CrossRef
  • Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation
    Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck
    Journal of Neuroinflammation.2018;[Epub]     CrossRef
  • Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin‐Induced Diabetic Mice
    Joo‐Hui Han, Nguyen Quoc Tuan, Min‐Ho Park, Khong Trong Quan, Joonseok Oh, Kyung‐Sun Heo, MinKyun Na, Chang‐Seon Myung
    Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
  • Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
    Robert W. Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M. Kurtz, Maria Trujillo, Dinko Gonzalez Trotter, Danqing Feng, Shiyao Xu, George Eiermann, Marie A. Holahan, Daniel Rubins, Stacey C
    Science.2017; 357(6350): 507.     CrossRef
  • Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk
    Mohammad Adil, Mohd Nizam Mansoori, Divya Singh, Amit Dattatraya Kandhare, Manju Sharma
    Biomedicine & Pharmacotherapy.2017; 94: 1010.     CrossRef
  • Rb2 inhibits α-glucosidase and regulates glucose metabolism by activating AMPK pathways in HepG2 cells
    Hui Teng, Lei Chen, Ting Fang, Benyao Yuan, Qiyang Lin
    Journal of Functional Foods.2017; 28: 306.     CrossRef
  • The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury
    Bing F. Wang, Jun Yoshioka
    Journal of Cardiovascular Pharmacology and Therapeutics.2017; 22(3): 219.     CrossRef
  • Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
    Adrián Hernández Alonso
    Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140.     CrossRef
  • Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells
    Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang, Hyeon Soo Kim
    Scientific Reports.2017;[Epub]     CrossRef
  • Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
    Prasenjit Manna, Arunkumar E. Achari, Sushil K. Jain
    Archives of Biochemistry and Biophysics.2017; 615: 22.     CrossRef
  • Care of the Athlete With Type 1 Diabetes Mellitus: A Clinical Review
    William B. Horton, Jose S. Subauste
    International Journal of Endocrinology and Metabolism.2016;[Epub]     CrossRef
  • Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice
    Joo-Hee Choi, P.B.Tirupathi Pichiah, Min-Jung Kim, Youn-Soo Cha
    Journal of Clinical Biochemistry and Nutrition.2016; 59(1): 31.     CrossRef
  • Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
    Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C. Jang, Kyong Soo Park
    Diabetes & Metabolism Journal.2016; 40(5): 406.     CrossRef
  • Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss
    H.P. Vasantha Rupasinghe, Satvir Sekhon-Loodu, Theodora Mantso, Mihalis I. Panayiotidis
    Pharmacology & Therapeutics.2016; 165: 153.     CrossRef
  • Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise
    Haiyan Wang, Naveen Sharma, Edward B. Arias, Gregory D. Cartee
    The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.2016; 71(3): 323.     CrossRef
  • Acute resistance exercise-induced IGF1 expression and subsequent GLUT4 translocation
    Kohei Kido, Satoru Ato, Takumi Yokokawa, Yuhei Makanae, Koji Sato, Satoshi Fujita
    Physiological Reports.2016; 4(16): e12907.     CrossRef
  • Regulation and function of AMPK in physiology and diseases
    Sang-Min Jeon
    Experimental & Molecular Medicine.2016; 48(7): e245.     CrossRef
  • Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
    Junjeong Choi, Ji-Hyun Lee, Ilkyoo Koh, Jin-Kyoung Shim, Junseong Park, Jeong Yong Jeon, Mijin Yun, Se Hoon Kim, Jong In Yook, Eui Hyun Kim, Jong Hee Chang, Sun Ho Kim, Yong Min Huh, Su Jae Lee, Michael Pollak, Pilnam Kim, Seok-Gu Kang, Jae-Ho Cheong
    Oncotarget.2016; 7(40): 65643.     CrossRef
  • [6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects
    Jung Ok Lee, Nami Kim, Hye Jeong Lee, Ji Wook Moon, Soo Kyung Lee, Su Jin Kim, Joong Kwan Kim, Sun Hwa Park, Hyeon Soo Kim
    Journal of Cellular Biochemistry.2015; 116(7): 1401.     CrossRef
  • A glance at … exercise and glucose uptake
    Michael J. Glade, Kyl Smith
    Nutrition.2015; 31(6): 893.     CrossRef
  • Exercising insulin sensitivity: AMPK turns on autophagy!
    Yossi Dagon, Christos Mantzoros, Young-Bum Kim
    Metabolism.2015; 64(6): 655.     CrossRef
  • Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice
    José M. Costa Júnior, Morgana R. Rosa, André O. Protzek, Flávia M. de Paula, Sandra M. Ferreira, Luiz F. Rezende, Emerielle C. Vanzela, Cláudio C. Zoppi, Leonardo R. Silveira, Isis C. Kettelhut, Antonio C. Boschero, Camila A. M. de Oliveira, Everardo M. C
    Amino Acids.2015; 47(4): 745.     CrossRef
  • Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells
    Xiang-Yang Zhang, Tong-Tong Zhang, Dan-Dan Song, Jun- Hao Zhou, Rong Han, Zheng-Hong Qin, Rui Sheng
    Molecular Brain.2015;[Epub]     CrossRef
  • Identification of adenine modulating AMPK activation in NIH/3T3 cells by proteomic approach
    Guang-Huar Young, Jiun-Tsai Lin, Yi-Fang Cheng, Chun-Fang Huang, Cheng-Yu Chao, Jing-Yi Nong, Po-Ku Chen, Han-Min Chen
    Journal of Proteomics.2015; 120: 204.     CrossRef
  • Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats
    Naveen Sharma, Haiyan Wang, Edward B. Arias, Carlos M. Castorena, Gregory D. Cartee
    American Journal of Physiology-Endocrinology and Metabolism.2015; 308(7): E603.     CrossRef
  • Human muscle fibre type‐specific regulation of AMPK and downstream targets by exercise
    Dorte E. Kristensen, Peter H. Albers, Clara Prats, Otto Baba, Jesper B. Birk, Jørgen F. P. Wojtaszewski
    The Journal of Physiology.2015; 593(8): 2053.     CrossRef
  • Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK
    Qun Huang, Lei Chen, Hui Teng, Hongbo Song, Xiaoqi Wu, Meiyu Xu
    Journal of Functional Foods.2015; 19: 487.     CrossRef
  • Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells
    Mohamad Abu Bakar, Kian-Kai Cheng, Mohamad Sarmidi, Harisun Yaakob, Hasniza Huri
    Molecules.2015; 20(5): 8242.     CrossRef
  • Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance
    Mark J. W. Hanssen, Roel Wierts, Joris Hoeks, Anne Gemmink, Boudewijn Brans, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetologia.2015; 58(3): 586.     CrossRef
  • Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise
    Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg
    Physiological Reports.2015; 3(7): e12444.     CrossRef
  • Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation
    Sukriti Krishan, Des R. Richardson, Sumit Sahni
    Molecular Pharmacology.2015; 87(3): 363.     CrossRef
  • Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle
    Takashi Sasaki, Rieko Nakata, Hiroyasu Inoue, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
    American Journal of Physiology-Endocrinology and Metabolism.2014; 306(9): E1085.     CrossRef
  • A novel heterozygous mutation in the glucokinase gene conferring exercise-induced symptomatic hyperglycaemia responsive to sulfonylurea
    M.S.E. Ebrahim, M.L. Lawson, M.T. Geraghty
    Diabetes & Metabolism.2014; 40(4): 310.     CrossRef
  • Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice
    Kwon-Il Seo, Jin Lee, Ra-Yeong Choi, Hae-In Lee, Ju-Hye Lee, Yong-Ki Jeong, Myung-Joo Kim, Mi-Kyung Lee
    Food & Function.2014; 5(7): 1579.     CrossRef
  • The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions
    M.F.P. Silvestre, B. Viollet, P.W. Caton, J. Leclerc, I. Sakakibara, M. Foretz, M.C. Holness, M.C. Sugden
    Life Sciences.2014; 100(1): 55.     CrossRef
  • Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation
    Fan-Lun Liu, Jui-Ling Hsu, Yean-Jang Lee, Yu-Shun Dong, Fan-Lu Kung, Ching-Shih Chen, Jih-Hwa Guh
    European Journal of Pharmacology.2014; 730: 90.     CrossRef
  • Fighting obesity: When muscle meets fat
    Xin Yang, Pengpeng Bi, Shihuan Kuang
    Adipocyte.2014; 3(4): 280.     CrossRef
  • Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway
    Bo-Lin Chen, Li-Ting Wang, Kuo-How Huang, Ching-Chia Wang, Chih-Kang Chiang, Shing-Hwa Liu
    The Journal of Nutritional Biochemistry.2014; 25(11): 1226.     CrossRef
  • AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
    Louise Lantier, Joachim Fentz, Rémi Mounier, Jocelyne Leclerc, Jonas T. Treebak, Christian Pehmøller, Nieves Sanz, Iori Sakakibara, Emmanuelle Saint‐Amand, Stéphanie Rimbaud, Pascal Maire, André Marette, Renée Ventura‐Clapier, Arnaud Ferry, Jørgen F. P. W
    The FASEB Journal.2014; 28(7): 3211.     CrossRef
  • Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity
    Mario Ost, Franziska Werner, Janine Dokas, Susanne Klaus, Anja Voigt, Juergen Eckel
    PLoS ONE.2014; 9(4): e94689.     CrossRef
  • Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
    Min-Jung Park, Dong-Il Kim, Seul-Ki Lim, Joo-Hee Choi, Jong-Choon Kim, Kyung-Chul Yoon, Jee-Bum Lee, Jae-Hyuk Lee, Ho-Jae Han, In-Pyo Choi, Hyoung-Chin Kim, Soo-Hyun Park
    Journal of Hepatology.2014; 61(5): 1151.     CrossRef
  • Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells
    Zhu Li, Chang-Lin Ni, Zhi Yao, Li-Ming Chen, Wen-Yan Niu
    Metabolism.2014; 63(8): 1022.     CrossRef
  • Effects of metformin on weight loss
    Steven K. Malin, Sangeeta R. Kashyap
    Current Opinion in Endocrinology, Diabetes & Obesity.2014; 21(5): 323.     CrossRef
  • Changes of Blood Glucose and Lactate Concentration in Body Wearing Firefighting Protective Equipments
    Chang-Hoon Bang
    Journal of Korean Society of Hazard Mitigation.2014; 14(1): 263.     CrossRef
  • Exercise, Energy Intake, Glucose Homeostasis, and the Brain
    Henriette van Praag, Monika Fleshner, Michael W. Schwartz, Mark P. Mattson
    The Journal of Neuroscience.2014; 34(46): 15139.     CrossRef
  • The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
    Takuya Sakurai, Junetsu Ogasawara, Takako Kizaki, Shogo Sato, Yoshinaga Ishibashi, Motoko Takahashi, Osamu Kobayashi, Shuji Oh-ishi, Junichi Nagasawa, Kazuto Takahashi, Hitoshi Ishida, Tetsuya Izawa, Hideki Ohno
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Flavonoids from Tetrastigma obtectum enhancing glucose consumption in insulin-resistance HepG2 cells via activating AMPK
    Mei-Na Jin, Guo-Ru Shi, Sheng-An Tang, Nan-Qin, Wei Qiao, Hong-Quan Duan
    Fitoterapia.2013; 90: 240.     CrossRef
  • AMPK, insulin resistance, and the metabolic syndrome
    Neil B. Ruderman, David Carling, Marc Prentki, José M. Cacicedo
    Journal of Clinical Investigation.2013; 123(7): 2764.     CrossRef
  • Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
    Veronica Martinez Marignac, Sarah Smith, Nader Toban, Miguel Bazile, Raquel Aloyz
    Oncotarget.2013; 4(12): 2550.     CrossRef
  • Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats
    Wenjuan Xing, Youyou Li, Haifeng Zhang, Chunjuan Mi, Zuoxu Hou, Michael J. Quon, Feng Gao
    American Journal of Physiology-Heart and Circulatory Physiology.2013; 305(8): H1111.     CrossRef
  • AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma
    Chin-Jung Hsu, Min-Huan Wu, Chin-Yuan Chen, Chun-Hao Tsai, Horng-Chaung Hsu, Chih-Hsin Tang
    Cell Communication and Signaling.2013;[Epub]     CrossRef
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Masayuki Saito
Diabetes Metab J. 2013;37(1):22-29.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.22
  • 5,654 View
  • 83 Download
  • 91 Crossref
AbstractAbstract PDFPubReader   

Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.

Citations

Citations to this article as recorded by  
  • Taraxacum mongolicum polysaccharide promotes white adipocyte browning by regulating miR-134-3p via Akt/GSK-3β signalling
    Xiaoyu Yue, Ling Zhong, Mengyan Ye, Yue Luan, Qiang Zhang, Qin Wang
    International Journal of Biological Macromolecules.2024; 257: 128296.     CrossRef
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • Nuciferine prevents obesity by activating brown adipose tissue
    Chunlong Yan, Yang Zhan, Shouli Yuan, Yujing Cao, Yi Chen, Meng Dong, Hanlin Zhang, Li Chen, Rui Jiang, Wenjun Liu, Wanzhu Jin, Yuanyuan Huang
    Food & Function.2024; 15(2): 967.     CrossRef
  • Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy
    Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
    Nutrients.2024; 16(4): 513.     CrossRef
  • CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
    Matthieu Leuillier, Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard, Raphaël G.P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiébaut, Isabelle Schmitz-Afonso, Séverine Nobis, Cynthia Campart,
    Journal of Advanced Research.2023; 43: 163.     CrossRef
  • Metabolic effects of lipectomy and of adipose tissue transplantation
    Sarah Davis, Samantha Hocking, Matthew J. Watt, Jenny E. Gunton
    Obesity.2023; 31(1): 7.     CrossRef
  • Modulation of the thermosensory system by oxytocin
    Ugo Zayan, Laura Caccialupi Da Prato, Françoise Muscatelli, Valéry Matarazzo
    Frontiers in Molecular Neuroscience.2023;[Epub]     CrossRef
  • Regenerative Medicine for Polycystic Ovary Syndrome: Stem Cell-Based Therapies and Brown Adipose Tissue Activation
    Mario Karam, Hélène Najjar, Marwan El Sabban, Aline Hamade, Fadia Najjar
    Stem Cell Reviews and Reports.2023; 19(4): 853.     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • p27Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice
    Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martinez, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
    International Journal of Molecular Sciences.2023; 24(3): 2664.     CrossRef
  • Energy metabolism and thermoregulation during sleep in young and old females
    Jaehoon Seol, Chihiro Kokudo, Insung Park, Simeng Zhang, Katsuhiko Yajima, Tomohiro Okura, Kumpei Tokuyama
    Scientific Reports.2023;[Epub]     CrossRef
  • Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
    Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew
    Scientific Reports.2023;[Epub]     CrossRef
  • Ado-Mediated Depletion of Taurine Impairs Mitochondrial Respiratory Capacity and Alters the Chromatin Landscape of Inguinal Adipose Tissue
    Pei-Yin Tsai, Bo Shui, Seoyeon Lee, Yang Liu, Yue Qu, Chloe Cheng, Kaydine Edwards, Callie Wong, Ryan Meng-Killeen, Paul D. Soloway, Joeva J. Barrow
    Nutrients.2023; 15(16): 3532.     CrossRef
  • Metabolic associated fatty liver disease is a disease related to sympathetic nervous system activation
    Zhao-Chun Chi
    World Chinese Journal of Digestology.2022; 30(11): 465.     CrossRef
  • Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
    Stefan Tholen, Roma Patel, Agnieszka Agas, Kyle M. Kovary, Atefeh Rabiee, Hayley T. Nicholls, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
    Cell Reports.2022; 39(13): 111018.     CrossRef
  • KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure
    Ju-hong Jang, Jeong Woong Lee, Min Ji Cho, Byungtae Hwang, Min-Gi Kwon, Dong-Hwan Kim, Nam-Kyung Lee, Jangwook Lee, Young-Jun Park, Yong Ryoul Yang, Jinchul Kim, Yong-Hoon Kim, Tae Hyeon An, Kyoung-Jin Oh, Kwang-Hee Bae, Jong-Gil Park, Jeong-Ki Min
    Experimental & Molecular Medicine.2022; 54(8): 1250.     CrossRef
  • Brown fat-associated postprandial thermogenesis in humans: Different effects of isocaloric meals rich in carbohydrate, fat, and protein
    Sayuri Aita, Mami Matsushita, Takeshi Yoneshiro, Takuya Hatano, Toshimitsu Kameya, Iwao Ohkubo, Masayuki Saito
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans
    Anna Borup, Ida Donkin, Mariëtte R. Boon, Martin Frydland, Borja Martinez-Tellez, Annika Loft, Sune H. Keller, Andreas Kjaer, Jesper Kjaergaard, Christian Hassager, Romain Barrès, Patrick C. N. Rensen, Christina Christoffersen
    Scientific Reports.2022;[Epub]     CrossRef
  • Signaling Pathways Regulating Thermogenesis
    Chihiro Tabuchi, Hei Sook Sul
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice
    Yejin Jeon, Ji-Young Choi, Eun-Hwa Jang, Je Kyung Seong, Kyunglim Lee
    International Journal of Obesity.2021; 45(7): 1576.     CrossRef
  • Diurnal variations of brown fat thermogenesis and fat oxidation in humans
    Mami Matsushita, Shinsuke Nirengi, Masanobu Hibi, Hitoshi Wakabayashi, Sang-il Lee, Masayuki Domichi, Naoki Sakane, Masayuki Saito
    International Journal of Obesity.2021; 45(11): 2499.     CrossRef
  • Adipose browning response to burn trauma is impaired with aging
    Abdikarim Abdullahi, Carly M. Knuth, Christopher Auger, Thibacg Sivayoganathan, Alexandra Parousis, Marc G. Jeschke
    JCI Insight.2021;[Epub]     CrossRef
  • The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
    Chang-Hyung Lee, Young-A Choi, Sung-Jin Heo, Parkyong Song
    International Journal of Environmental Research and Public Health.2021; 18(17): 9165.     CrossRef
  • Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
    Okamatsu-Ogura Yuko, Masayuki Saito
    Diabetes & Metabolism Journal.2021; 45(6): 840.     CrossRef
  • Comparative Transcriptome Profiling of Young and Old Brown Adipose Tissue Thermogenesis
    Yumin Kim, Baeki E. Kang, Dongryeol Ryu, So Won Oh, Chang-Myung Oh
    International Journal of Molecular Sciences.2021; 22(23): 13143.     CrossRef
  • Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring
    Tiange Li, Han Gong, Qichen Yuan, Min Du, Fazheng Ren, Xueying Mao
    The FASEB Journal.2020; 34(3): 4619.     CrossRef
  • Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: Sex-related differences
    T.C. Peixoto, E.G. Moura, P.N. Soares, I.M. Bertasso, C.B. Pietrobon, F.A.H. Caramez, R.A. Miranda, E. Oliveira, A.C. Manhães, P.C. Lisboa
    Food and Chemical Toxicology.2020; 140: 111328.     CrossRef
  • Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice
    Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
    Cell Reports.2020; 33(1): 108237.     CrossRef
  • Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway
    Subramani Manigandan, Jong Won Yun
    Biotechnology and Bioprocess Engineering.2020; 25(3): 345.     CrossRef
  • Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men
    Masayuki Saito, Mami Matsushita, Takeshi Yoneshiro, Yuko Okamatsu-Ogura
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Differences in [18F]FDG uptake in BAT of UCP1 −/− and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis
    Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan, Rosa T. Branca
    EJNMMI Research.2020;[Epub]     CrossRef
  • Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
    Ineke H.N. Luijten, Barbara Cannon, Jan Nedergaard
    Molecular Aspects of Medicine.2019; 68: 42.     CrossRef
  • Sexual Dimorphism of Brown Adipose Tissue Function
    Lindsay J. Robinson, James Law, Valerie Astle, Marta Gutiérrez-García, Shalini Ojha, Michael E. Symonds, Nicola Pitchford, Helen Budge
    The Journal of Pediatrics.2019; 210: 166.     CrossRef
  • Cold Induced Depot-Specific Browning in Ferret Aortic Perivascular Adipose Tissue
    Bàrbara Reynés, Evert M. van Schothorst, Jaap Keijer, Enzo Ceresi, Paula Oliver, Andreu Palou
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism
    Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio
    Nutrition & Metabolism.2019;[Epub]     CrossRef
  • Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice
    Gabriela Cavazza Cerri, Leandro Ceotto Freitas Lima, Deborah de Farias Lelis, Lucíola da Silva Barcelos, John David Feltenberger, Samuel Vidal Mussi, Renato Sobral Monteiro-Junior, Robson Augusto Souza dos Santos, Lucas Antônio Miranda Ferreira, Sérgio He
    Life Sciences.2019; 218: 292.     CrossRef
  • Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
    Qinyang Jiang, Xiaofang Cheng, Yueyue Cui, Qin Xia, Xueyu Yan, Mingyuan Zhang, Ganqiu Lan, Jiaqi Liu, Tizhong Shan, Yanna Huang
    Food & Function.2019; 10(6): 3334.     CrossRef
  • Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
    Yea Eun Kang, Hyun Jin Kim, Minho Shong
    Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
  • Inter‐organ communication: a gatekeeper for metabolic health
    Judit Castillo‐Armengol, Lluis Fajas, Isabel C Lopez‐Mejia
    EMBO reports.2019;[Epub]     CrossRef
  • Clinical Implications of UCP1 mRNA Expression in Human Cervical Adipose Tissue Under Physiological Conditions
    Ju Hee Lee, Ji Min Kim, Min Jeong Choi, Yea Eun Kang, Kyoung Hye Joung, Hyon‐Seung Yi, Koon Soon Kim, Bon Jeong Ku, Bon Seok Koo, Minho Shong, Hyun Jin Kim
    Obesity.2018; 26(6): 1008.     CrossRef
  • Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
    Kenneth D’Souza, Geena Paramel, Petra Kienesberger
    Nutrients.2018; 10(4): 399.     CrossRef
  • Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
    Clément Pierre, Florent Guillebaud, Coraline Airault, Nathalie Baril, Rym Barbouche, Etienne Save, Stéphanie Gaigé, Bruno Bariohay, Michel Dallaporta, Jean-Denis Troadec
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes
    Kanae Nakamura, Tsunao Kishida, Akika Ejima, Riho Tateyama, Satoru Morishita, Tomoji Ono, Michiaki Murakoshi, Keikichi Sugiyama, Hoyoku Nishino, Osam Mazda
    BioMetals.2018; 31(3): 415.     CrossRef
  • Association of wrist and ambient temperature with cold-induced brown adipose tissue and skeletal muscle [18F]FDG uptake in young adults
    Borja Martinez-Tellez, Huiwen Xu, Guillermo Sanchez-Delgado, Francisco M. Acosta, Patrick C. N. Rensen, Jose M. Llamas-Elvira, Jonatan R. Ruiz
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1281.     CrossRef
  • Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
    Yongguo Li, Katharina Schnabl, Sarah-Madeleine Gabler, Monja Willershäuser, Josefine Reber, Angelos Karlas, Sanna Laurila, Minna Lahesmaa, Mueez u Din, Andrea Bast-Habersbrunner, Kirsi A. Virtanen, Tobias Fromme, Florian Bolze, Libbey S. O’Farrell, Jorge
    Cell.2018; 175(6): 1561.     CrossRef
  • Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
    G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
    International Journal of Obesity.2018; 42(3): 542.     CrossRef
  • Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
    Daniel C. Berry, Yuwei Jiang, Robert W. Arpke, Elizabeth L. Close, Aki Uchida, David Reading, Eric D. Berglund, Michael Kyba, Jonathan M. Graff
    Cell Metabolism.2017; 25(1): 166.     CrossRef
  • Postprandial Increase in Energy Expenditure Correlates with Body Weight Reduction in Patients with Type 2 Diabetes Receiving Diet Therapy
    Daisuke Sanoyama, Mototsugu Nagao, Akira Asai, Yuko Nakamura, Kazumi Sato, Yasushi Nakajima, Shinichi Oikawa, Hitoshi Sugihara
    Journal of Atherosclerosis and Thrombosis.2017; 24(4): 422.     CrossRef
  • Physiological regulation and metabolic role of browning in white adipose tissue
    Aleksandra Jankovic, Vesna Otasevic, Ana Stancic, Biljana Buzadzic, Aleksandra Korac, Bato Korac
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
    Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
    Daniela Guarino, Monica Nannipieri, Giorgio Iervasi, Stefano Taddei, Rosa Maria Bruno
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans
    Takayuki Nishimura, Takafumi Katsumura, Midori Motoi, Hiroki Oota, Shigeki Watanuki
    Scientific Reports.2017;[Epub]     CrossRef
  • Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation
    Yuwei Jiang, Daniel C Berry, Jonathan M Graff
    eLife.2017;[Epub]     CrossRef
  • Ovarian hormones and obesity
    Brigitte Leeners, Nori Geary, Philippe N. Tobler, Lori Asarian
    Human Reproduction Update.2017; 23(3): 300.     CrossRef
  • Nutritional approaches for managing obesity-associated metabolic diseases
    Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
    Journal of Endocrinology.2017; 233(3): R145.     CrossRef
  • Lower core body temperature and greater body fat are components of a human thrifty phenotype
    M Reinhardt, M Schlögl, S Bonfiglio, S B Votruba, J Krakoff, M S Thearle
    International Journal of Obesity.2016; 40(5): 754.     CrossRef
  • Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
    Aleix Gavaldà-Navarro, José M. Moreno-Navarrete, Tania Quesada-López, Montserrat Cairó, Marta Giralt, José M. Fernández-Real, Francesc Villarroya
    Diabetologia.2016; 59(10): 2208.     CrossRef
  • Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function
    Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff
    Nature Communications.2016;[Epub]     CrossRef
  • Control of human energy expenditure by cytochrome c oxidase subunit IV-2
    Tomas A. Schiffer, Maria Peleli, Michaela L. Sundqvist, Björn Ekblom, Jon O. Lundberg, Eddie Weitzberg, Filip J. Larsen
    American Journal of Physiology-Cell Physiology.2016; 311(3): C452.     CrossRef
  • Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species
    Lars Rebiger, Sigurd Lenzen, Ilir Mehmeti
    Bioscience Reports.2016;[Epub]     CrossRef
  • Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
    Mark J.W. Hanssen, Anouk A.J.J. van der Lans, Boudewijn Brans, Joris Hoeks, Kelly M.C. Jardon, Gert Schaart, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetes.2016; 65(5): 1179.     CrossRef
  • Phytochemicals as novel agents for the induction of browning in white adipose tissue
    Yusra Azhar, Ashish Parmar, Colette N. Miller, Janaiya S. Samuels, Srujana Rayalam
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Energy expenditure and intake during puberty in healthy nonobese adolescents: a systematic review
    Hoi Lun Cheng, Mazen Amatoury, Katharine Steinbeck
    The American Journal of Clinical Nutrition.2016; 104(4): 1061.     CrossRef
  • MRI characterization of brown adipose tissue in obese and normal-weight children
    Jie Deng, Samantha E. Schoeneman, Huiyuan Zhang, Soyang Kwon, Cynthia K. Rigsby, Richard M. Shore, Jami L. Josefson
    Pediatric Radiology.2015; 45(11): 1682.     CrossRef
  • A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
    Martin Reinhardt, Marie S. Thearle, Mostafa Ibrahim, Maximilian G. Hohenadel, Clifton Bogardus, Jonathan Krakoff, Susanne B. Votruba
    Diabetes.2015; 64(8): 2859.     CrossRef
  • Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    S Wang, X Liang, Q Yang, X Fu, C J Rogers, M Zhu, B D Rodgers, Q Jiang, M V Dodson, M Du
    International Journal of Obesity.2015; 39(6): 967.     CrossRef
  • Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
    Masayuki Saito
    The Korean Journal of Obesity.2015; 24(1): 1.     CrossRef
  • Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes
    Colette N. Miller, Jeong-Yeh Yang, Emily England, Amelia Yin, Clifton A. Baile, Srujana Rayalam, Graça Soveral
    PLOS ONE.2015; 10(9): e0138344.     CrossRef
  • Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity
    M. Luisa Bonet, Jose A. Canas, Joan Ribot, Andreu Palou
    Archives of Biochemistry and Biophysics.2015; 572: 112.     CrossRef
  • Calorie hoarding and thrifting: Foxa3 finds a way
    Xinran Ma, Lingyan Xu, Elisabetta Mueller
    Adipocyte.2015; 4(4): 325.     CrossRef
  • Can thermogenic adipocytes protect from obesity?
    L. N. Medvedev, E. I. Elsukova
    Journal of Physiology and Biochemistry.2015; 71(4): 847.     CrossRef
  • Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice
    Yuko Okamatsu-Ogura, Ayumi Tsubota, Kana Ohyama, Yoshihito Nogusa, Masayuki Saito, Kazuhiro Kimura
    Journal of Functional Foods.2015; 19: 1.     CrossRef
  • Energy Expenditure in Humans and Other Primates: A New Synthesis
    Herman Pontzer
    Annual Review of Anthropology.2015; 44(1): 169.     CrossRef
  • Gene expression of peripheral blood mononuclear cells is affected by cold exposure
    Bàrbara Reynés, Estefanía García-Ruiz, Paula Oliver, Andreu Palou
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R824.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
    PLOS ONE.2015; 10(11): e0141724.     CrossRef
  • Food Ingredients as Anti-Obesity Agents
    Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
    Trends in Endocrinology & Metabolism.2015; 26(11): 585.     CrossRef
  • Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity
    Yumie Morimoto-Kobayashi, Kazuaki Ohara, Chika Takahashi, Sayoko Kitao, Guanying Wang, Yoshimasa Taniguchi, Mikio Katayama, Katsuya Nagai, Qinghua Sun
    PLOS ONE.2015; 10(6): e0131042.     CrossRef
  • Role of forkhead box protein A3 in age-associated metabolic decline
    Xinran Ma, Lingyan Xu, Oksana Gavrilova, Elisabetta Mueller
    Proceedings of the National Academy of Sciences.2014; 111(39): 14289.     CrossRef
  • Thermoneutrality results in prominent diet‐induced body weight differences in C57BL/6J mice, not paralleled by diet‐induced metabolic differences
    Femke P. M. Hoevenaars, Melissa Bekkenkamp‐Grovenstein, Rolf J. R. J. Janssen, Sandra G. Heil, Annelies Bunschoten, Elise F. Hoek‐van den Hil, Sophie Snaas‐Alders, Katja Teerds, Evert M. van Schothorst, Jaap Keijer
    Molecular Nutrition & Food Research.2014; 58(4): 799.     CrossRef
  • Vijftig tinten vet
    Mattees van Dijk
    Tijdschrift voor praktijkondersteuning.2014; 9(6): 170.     CrossRef
  • MRI detection of brown adipose tissue with low fat content in newborns with hypothermia
    Houchun H. Hu, Tai-Wei Wu, Larry Yin, Mimi S. Kim, Jonathan M. Chia, Thomas G. Perkins, Vicente Gilsanz
    Magnetic Resonance Imaging.2014; 32(2): 107.     CrossRef
  • The origin and definition of brite versus white and classical brown adipocytes
    Matthias Rosenwald, Christian Wolfrum
    Adipocyte.2014; 3(1): 4.     CrossRef
  • Expression of “brown-in-white” adipocyte biomarkers shows gender differences and the influence of early dietary exposure
    María Servera, Nora López, Francisca Serra, Andreu Palou
    Genes & Nutrition.2014;[Epub]     CrossRef
  • Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
    Paul Lee, Sheila Smith, Joyce Linderman, Amber B. Courville, Robert J. Brychta, William Dieckmann, Charlotte D. Werner, Kong Y. Chen, Francesco S. Celi
    Diabetes.2014; 63(11): 3686.     CrossRef
  • Food Function Study of Obesity and Fat Energy Metabolism
    Teruo Kawada
    Nippon Eiyo Shokuryo Gakkaishi.2014; 67(3): 119.     CrossRef
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
    Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano, Teruo Kawada
    Food Science & Nutrition.2014; 2(6): 634.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2013; 32(6): 397.     CrossRef
  • Ghrelin
    Geetali Pradhan, Susan L. Samson, Yuxiang Sun
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 619.     CrossRef
  • Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management
    Takeshi Yoneshiro, Masayuki Saito
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 625.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular.2013; 32(6): 397.     CrossRef
Nutritional Status and Cardiac Autophagy
Jihyun Ahn, Jaetaek Kim
Diabetes Metab J. 2013;37(1):30-35.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.30
  • 3,522 View
  • 34 Download
  • 16 Crossref
AbstractAbstract PDFPubReader   

Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it may have a cardioprotective effect by decreasing oxidative damage brought on by aging and cardiovascular diseases. Although cardiac autophagy is critical to regulating protein quality and maintaining cellular function and survival, increased or excessive autophagy may have deleterious effects on the heart under some circumstances, including pressure overload-induced heart failure. The importance of autophagy has been shown in nutrient supply and preservation of energy in times of limitation, such as ischemia. Some studies have suggested that a transition from obesity to metabolic syndrome may involve progressive changes in myocardial inflammation, mitochondrial dysfunction, fibrosis, apoptosis, and myocardial autophagy.

Citations

Citations to this article as recorded by  
  • The Newly Proposed Mechanism of Cardiomyocyte Protection of Carvedilol- Anti-Apoptosis Pattern of Carvedilol in Anoxia by Inducing Autophagy Partly through the AMPK/mTOR Pathway
    Jingru Li, Chaozhong Li, Guihu Sun, Longjun Li, Yongli Zeng, Huawei Wang, Xinyu Wu, Ping Yang, Yunzhu Peng, Luqiao Wang
    Letters in Drug Design & Discovery.2023; 20(10): 1600.     CrossRef
  • Mitophagy for cardioprotection
    Allen Sam Titus, Eun-Ah Sung, Daniela Zablocki, Junichi Sadoshima
    Basic Research in Cardiology.2023;[Epub]     CrossRef
  • Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models
    Minru Liao, Qiang Xie, Yuqian Zhao, Chengcan Yang, Congcong Lin, Guan Wang, Bo Liu, Lingjuan Zhu
    Pharmacological Research.2022; 176: 106077.     CrossRef
  • How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives
    Giovanni Corsetti, Evasio Pasini, Claudia Romano, Carol Chen-Scarabelli, Tiziano M. Scarabelli, Vincenzo Flati, Louis Saravolatz, Francesco S. Dioguardi
    International Journal of Molecular Sciences.2021; 22(7): 3332.     CrossRef
  • Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation
    Vasantha L. Kolachala, Chrissy Lopez, Ming Shen, Dmitry Shayakhmetov, Nitika Arora Gupta
    Apoptosis.2021; 26(5-6): 361.     CrossRef
  • Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells
    Yunchun Kuang, Bo Hu, Ge Feng, Mingli Xiang, Yuejia Deng, Minmin Tan, Jie Li, Jinlin Song
    Biogerontology.2020; 21(1): 13.     CrossRef
  • Protective effects of salvianolic acid B against hydrogen peroxide‑induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms
    Shan Gao, Shiqin Li, Qin Li, Fuyong Zhang, Mengqi Sun, Zilin Wan, Shurong Wang
    International Journal of Molecular Medicine.2019;[Epub]     CrossRef
  • Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression
    Wei Yu, Jinjin Qin, Chunjuan Chen, Yucai Fu, Wei Wang
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • Cardiac fibrosis in the ageing heart: Contributors and mechanisms
    Lu Lu, Jingbin Guo, Yue Hua, Kevin Huang, Ruth Magaye, Jake Cornell, Darren J. Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Aihua Chen, Wei Xiao, Qiang Fu, Bing Hui Wang
    Clinical and Experimental Pharmacology and Physiology.2017; 44(S1): 55.     CrossRef
  • MicroRNA-199a acts as a potential suppressor of cardiomyocyte autophagy through targeting Hspa5
    Liang Chen, Fei-Yu Wang, Zhen-Yu Zeng, Ling Cui, Jian Shen, Xiao-Wei Song, Pan Li, Xian-Xian Zhao, Yong-Wen Qin
    Oncotarget.2017; 8(38): 63825.     CrossRef
  • Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells
    Hong Yao, Lichun Zhou, Linlin Tang, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han
    BioScience Trends.2017; 11(5): 557.     CrossRef
  • Hongjingtian Injection Attenuates Myocardial Oxidative Damage via Promoting Autophagy and Inhibiting Apoptosis
    Shujing Zhang, Ling Zhang, Han Zhang, Guanwei Fan, Jiuwen Qiu, Zongbao Fang, Haibo Wu, Yi Wang, Xiaoping Zhao
    Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
  • Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts
    S Ghavami, R H Cunnington, S Gupta, B Yeganeh, K L Filomeno, D H Freed, S Chen, T Klonisch, A J Halayko, E Ambrose, R Singal, I M C Dixon
    Cell Death & Disease.2015; 6(3): e1696.     CrossRef
  • The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie‐restricted mouse heart
    Julia Schipke, Ewgenija Banmann, Sandeep Nikam, Robert Voswinckel, Karin Kohlstedt, Annemarieke E. Loot, Ingrid Fleming, Christian Mühlfeld
    Journal of Anatomy.2014; 225(5): 539.     CrossRef
  • Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
    Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
    Endocrinology.2013; 154(8): 2626.     CrossRef
  • Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
    Stephen C. Kolwicz, Suneet Purohit, Rong Tian
    Circulation Research.2013; 113(5): 603.     CrossRef
Editorial
The Efficacy of Vildagliptin in Korean Patients with Type 2 Diabetes
Jun Sung Moon, Kyu Chang Won
Diabetes Metab J. 2013;37(1):36-39.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.36
  • 2,787 View
  • 27 Download
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • The effect of glargine versus glimepiride on pancreatic β-cell function in patients with type 2 diabetes uncontrolled on metformin monotherapy: open-label, randomized, controlled study
    Jun Sung Moon, Kyoung Soo Ha, Ji Sung Yoon, Hyoung Woo Lee, Hyun Chul Lee, Kyu Chang Won
    Acta Diabetologica.2014; 51(2): 277.     CrossRef
Original Articles
Factor Structure of Indices of the Second Derivative of the Finger Photoplethysmogram with Metabolic Components and Other Cardiovascular Risk Indicators
Tomoyuki Kawada, Toshiaki Otsuka
Diabetes Metab J. 2013;37(1):40-45.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.40
  • 3,118 View
  • 29 Download
  • 8 Crossref
AbstractAbstract PDFPubReader   
Background

The second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among various cardiovascular risk factors.

Methods

The SDPTG was determined in the second forefinger of the left hand in 1,055 male workers (mean age, 44.2±6.4 years). Among 4 waves of SDPTG components, the ratios of the height of the "a" wave to that of the "b" and "d" waves were expressed as b/a and d/a, and used as SDPTG indices for the analysis.

Results

Principal axis factoring analysis was conducted using age, SDPTG indices, components of MetS, and the serum levels of C-reactive protein (CRP) and uric acid. Three factors were extracted, and the SDPTG indices were categorized in combination with age as the third factor. Metabolic components and the SDPTG indices were independently categorized. These three factors explained 44.4% of the total variation. Multiple logistic regression analysis revealed age, d/a, serum uric acid, serum CRP, and regular exercise as independent determinants of the risk of MetS. The odds ratios (95% confidence intervals) were 1.08 (1.04 to 1.11), 0.10 (0.01 to 0.73), 1.24 (1.06 to 1.44), 3.59 (2.37 to 5.42), and 0.48 (0.28 to 0.82), respectively.

Conclusion

The SDPTG indices were categorized in combination with age, and they differed in characteristics from components of MetS or inflammatory markers. In addition, this cross-sectional study also revealed decrease of the d/a as a risk factor for the development of MetS.

Citations

Citations to this article as recorded by  
  • Presence of hypertension might pose a potential pitfall in detection of diabetes mellitus non-invasively using the second derivative of photoplethysmography
    Ahmet Taş, Yaren Alan, Ilke Kara, Abdullah Savas, Muhammed Ikbal Bayhan, Diren Ekici, Zeynep Atay, Fatih Sezer, Cagla Kitapli, Sabahattin Umman, Murat Sezer
    Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization.2024;[Epub]     CrossRef
  • Diagnostic Features and Potential Applications of PPG Signal in Healthcare: A Systematic Review
    Malak Abdullah Almarshad, Md Saiful Islam, Saad Al-Ahmadi, Ahmed S. BaHammam
    Healthcare.2022; 10(3): 547.     CrossRef
  • Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review
    Vincent G. Pluimakers, Selveta S. van Santen, Marta Fiocco, Marie‐Christine E. Bakker, Aart J. van der Lelij, Marry M. van den Heuvel‐Eibrink, Sebastian J. C. M. M. Neggers
    Obesity Reviews.2021;[Epub]     CrossRef
  • Age-Related Changes in the Characteristics of the Elderly Females Using the Signal Features of an Earlobe Photoplethysmogram
    Jeong-Woo Seo, Jungmi Choi, Kunho Lee, Jaeuk U. Kim
    Sensors.2021; 21(23): 7782.     CrossRef
  • Screening Test on Metabolic Syndrome Using Electro Interstitial Scan Instrument


    Phawit Norchai, Thipaporn Tharavanij, Picha Suwannahitatorn, Thammanard Charernboon
    Medical Devices: Evidence and Research.2020; Volume 13: 237.     CrossRef
  • Evaluation of Cardiorespiratory Function During Cardiopulmonary Exercise Testing in Untreated Hypertensive and Healthy Subjects
    Yahui Zhang, Zhihao Jiang, Lin Qi, Lisheng Xu, Xingguo Sun, Xinmei Chu, Yanling Liu, Tianjing Zhang, Stephen E. Greenwald
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Second derivative of the finger photoplethysmogram and cardiovascular mortality in middle-aged and elderly Japanese women
    Noriko Inoue, Hideshi Kawakami, Hideya Yamamoto, Chikako Ito, Saeko Fujiwara, Hideo Sasaki, Yasuki Kihara
    Hypertension Research.2017; 40(2): 207.     CrossRef
  • Photoplethysmogram second derivative review: Analysis and applications
    K Qawqzeh Yousef, Uldis Rubins, Alharbi Mafawez
    Scientific Research and Essays.2015; 10(21): 633.     CrossRef
Increasing Prevalence of Type 2 Diabetes in a Rural Bangladeshi Population: A Population Based Study for 10 Years
Bishwajit Bhowmik, Faria Afsana, Lien My Diep, Sanjida Binte Munir, Erica Wright, Sharif Mahmood, A. K. Azad Khan, Akhtar Hussain
Diabetes Metab J. 2013;37(1):46-53.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.46
  • 4,732 View
  • 38 Download
  • 27 Crossref
AbstractAbstract PDFPubReader   
Background

To observe changes in the prevalence of type 2 diabetes mellitus (DM) and impaired fasting glucose (IFG) and its associated risk factors in a rural Bangladeshi population over a 10-year period.

Methods

Three cross-sectional studies were undertaken in a rural community (aged ≥20 years) in 1999, 2004, and 2009. Structured questionnaires including sociodemographic parameters, anthropometric measurements, blood pressure, and blood glucose values were recorded. DM and IFG were diagnosed using 1999 World Health Organization criteria.

Results

Age standardized prevalence of DM increased significantly (P<0.001) from 1999 to 2009 (2.3%, 6.8%, and 7.9% in 1999, 2004, and 2009, respectively). The prevalence of IFG increased significantly (P=0.011) from 4.6% to 5.8% between 1999 and 2004 but then decreased from 5.8% to 5.3% during 2004 to 2009. Significant linear trends were shown in both sexes for general and central obesity as indicated by body mass index, waist circumference, and waist hip ratio (WHR). Increasing age and systolic blood pressure were significant risk factors for DM in all three studies. WHR for males was also significantly associated with the risk of DM in all three studies. WHR for females was only significantly associated with DM in 2009.

Conclusion

A significant rise in the prevalence of DM was observed in this population over 10 years. This increase was seen in both sexes, and in all age groups. A significant increase in the prevalence of the associated risk factors of general and central obesity was observed in both sexes.

Citations

Citations to this article as recorded by  
  • Depression and health-related quality of life of patients with type 2 diabetes attending tertiary level hospitals in Dhaka, Bangladesh
    Manish K. Namdeo, Sarita Verma, Rajat Das Gupta, Rubana Islam, Shaila Nazneen, Lal B. Rawal
    Global Health Research and Policy.2023;[Epub]     CrossRef
  • A quantile regression approach to identify risk factors for high blood glucose levels among Bangladeshi individuals
    Mst. Farjana Aktar, Mashfiqul Huq Chowdhury, Md. Siddikur Rahman
    Health Science Reports.2023;[Epub]     CrossRef
  • Association of anthropometric indices with cardiometabolic risk factors in adult Bangladeshi population
    Farah-Sul Lail, Shamima Afrin, Md Mozammel Haque
    Obesity Medicine.2022; 34: 100444.     CrossRef
  • Diabetes among adults in Bangladesh: changes in prevalence and risk factors between two cross-sectional surveys
    Muhammad Abdul Baker Chowdhury, Mirajul Islam, Jakia Rahman, Md Jamal Uddin, Md. Rabiul Haque
    BMJ Open.2022; 12(8): e055044.     CrossRef
  • Community groups or mobile phone messaging to prevent and control type 2 diabetes and intermediate hyperglycaemia in Bangladesh (DMagic): a cluster-randomised controlled trial
    Edward Fottrell, Naveed Ahmed, Joanna Morrison, Abdul Kuddus, Sanjit Kumer Shaha, Carina King, Hannah Jennings, Kohenour Akter, Tasmin Nahar, Hassan Haghparast-Bidgoli, A K Azad Khan, Anthony Costello, Kishwar Azad
    The Lancet Diabetes & Endocrinology.2019; 7(3): 200.     CrossRef
  • Inequalities in the prevalence of diabetes mellitus and its risk factors in Sri Lanka: a lower middle income country
    Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Rashan Haniffa, Isurujith Kongala Liyanage, Saroj Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne, Lalini Chandika Rajapaksa
    International Journal for Equity in Health.2018;[Epub]     CrossRef
  • Awareness, prevalence, treatment, and control of type 2 diabetes in a semi-urban area of Nepal: Findings from a cross-sectional study conducted as a part of COBIN-D trial
    Bishal Gyawali, Martin Rune Hassan Hansen, Mia Buhl Povlsen, Dinesh Neupane, Peter Krogh Andersen, Craig Steven McLachlan, Annelli Sandbæk, Abhinav Vaidya, Per Kallestrup, Andrew Soundy
    PLOS ONE.2018; 13(11): e0206491.     CrossRef
  • Distribution of diabetes, hypertension and non-communicable disease risk factors among adults in rural Bangladesh: a cross-sectional survey
    Edward Fottrell, Naveed Ahmed, Sanjit Kumer Shaha, Hannah Jennings, Abdul Kuddus, Joanna Morrison, Kohenour Akter, Badrun Nahar, Tasmin Nahar, Hassan Haghparast-Bidgoli, A K Azad Khan, Anthony Costello, Kishwar Azad
    BMJ Global Health.2018; 3(6): e000787.     CrossRef
  • Serum Homocysteine and Its Association with Lipid Profile in Type II Diabetes Mellitus
    Bushra Fiza, Jaishree Choudhary, Maheep Sinha, Rati Mathur
    Indian journal of Medical Biochemistry.2018; 22(1): 26.     CrossRef
  • A Culturally Tailored Community Health Worker Intervention Leads to Improvement in Patient-Centered Outcomes for Immigrant Patients With Type 2 Diabetes
    Nadia S. Islam, Laura C. Wyatt, M.D. Taher, Lindsey Riley, S. Darius Tandon, Michael Tanner, B. Runi Mukherji, Chau Trinh-Shevrin
    Clinical Diabetes.2018; 36(2): 100.     CrossRef
  • Diabetes risk score for identifying cardiometabolic risk factors in adult Bangladeshi population
    Bishwajit Bhowmik, Tasnima Siddiquee, Anindita Mujumder, Tofail Ahmed, Hajera Mahtab, AbulKalam Azad Khan, Akhtar Hussain, Gerd Holmboe-Ottesen, ToneKristin Omsland
    Journal of Diabetology.2018; 9(3): 95.     CrossRef
  • Prediabetes, diagnosed and undiagnosed diabetes, their risk factors and association with knowledge of diabetes in rural Bangladesh: The Bangladesh Population‐based Diabetes and Eye Study
    Fakir M. Amirul Islam, Rahul Chakrabarti, M. Tauhidul Islam, Mohammad Wahab, Ecosse Lamoureux, Robert P. Finger, Jonathan E. Shaw
    Journal of Diabetes.2016; 8(2): 260.     CrossRef
  • The effect of community groups and mobile phone messages on the prevention and control of diabetes in rural Bangladesh: study protocol for a three-arm cluster randomised controlled trial
    Edward Fottrell, Hannah Jennings, Abdul Kuddus, Naveed Ahmed, Joanna Morrison, Kohenour Akter, Sanjit Kumar Shaha, Badrun Nahar, Tasmin Nahar, Hassan Haghparast-Bidgoli, A. K. Azad Khan, Anthony Costello, Kishwar Azad
    Trials.2016;[Epub]     CrossRef
  • Blood glucose and cholesterol levels in adult population of Bangladesh: Results from STEPS 2006 survey
    M. Mostafa Zaman, Sohel Reza Choudhury, Jasimuddin Ahmed, Md. Habibullah Talukder, A.H.M. Shafiqur Rahman
    Indian Heart Journal.2016; 68(1): 52.     CrossRef
  • A survey on socioeconomic determinants of diabetes mellitus management in a lower middle income setting
    Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Rashan Haniffa, Isurujith Kongala Liyanage, Kosala Saroj Amarasiri Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne, Lalini Chandika Rajapakse
    International Journal for Equity in Health.2016;[Epub]     CrossRef
  • Factors that could explain the increasing prevalence of type 2 diabetes among adults in a Canadian province: a critical review and analysis
    Véronique Thibault, Mathieu Bélanger, Emilie LeBlanc, Lise Babin, Stuart Halpine, Beverly Greene, Michelina Mancuso
    Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
  • Factors Associated with Awareness, Attitudes and Practices Regarding Common Eye Diseases in the General Population in a Rural District in Bangladesh: The Bangladesh Population-based Diabetes and Eye Study (BPDES)
    Fakir M. Amirul Islam, Rahul Chakrabarti, Silvia Z. Islam, Robert P. Finger, Christine Critchley, Rohit C. Khanna
    PLOS ONE.2015; 10(7): e0133043.     CrossRef
  • Obesity and associated type 2 diabetes and hypertension in factory workers of Bangladesh
    Bishwajit Bhowmik, Faria Afsana, Tareen Ahmed, Sadeka Akhter, Hasan Ali Choudhury, Anisur Rahman, Tofail Ahmed, Hajera Mahtab, A. K. Azad Khan
    BMC Research Notes.2015;[Epub]     CrossRef
  • Type 2 diabetes and its correlates among adults in Bangladesh: a population based study
    Muhammad Abdul Baker Chowdhury, Md Jamal Uddin, Hafiz M. R. Khan, Md Rabiul Haque
    BMC Public Health.2015;[Epub]     CrossRef
  • Societal Costs of Diabetes Mellitus 2025 and 2040—Forecasts Based on Real World Cost Evidence and Observed Epidemiological Trends in Denmark
    Camilla Sortsø, Martha Emneus, Anders Green, Peter Bjødstrup Jensen, Thomas Eriksson
    Modern Economy.2015; 06(10): 1150.     CrossRef
  • Simple risk score to detect rural Asian Indian (Bangladeshi) adults at high risk for type 2 diabetes
    Bishwajit Bhowmik, Afroza Akhter, Liaquat Ali, Tofail Ahmed, Faruque Pathan, Hajera Mahtab, Abul Kalam Azad Khan, Akhtar Hussain
    Journal of Diabetes Investigation.2015; 6(6): 670.     CrossRef
  • Prevalence of diabetes and prediabetes and their risk factors among Bangladeshi adults: a nationwide survey
    Shamima Akter, M Mizanur Rahman, Sarah Krull Abe, Papia Sultana
    Bulletin of the World Health Organization.2014; 92(3): 204.     CrossRef
  • Development of Multidrug Resistant Tuberculosis in Bangladesh: A Case-Control Study on Risk Factors
    Mahfuza Rifat, Abul Hasnat Milton, John Hall, Christopher Oldmeadow, Md. Akramul Islam, Ashaque Husain, Md. Wahiduzzaman Akhanda, Bodrun Naher Siddiquea, Ulrike Gertrud Munderloh
    PLoS ONE.2014; 9(8): e105214.     CrossRef
  • Knowledge, Attitudes and Practice of Diabetes in Rural Bangladesh: The Bangladesh Population Based Diabetes and Eye Study (BPDES)
    Fakir M. Amirul Islam, Rahul Chakrabarti, Mohamed Dirani, M. Tauhidul Islam, Gail Ormsby, Mohamed Wahab, Christine Critchley, Robert P. Finger, Utpal Sen
    PLoS ONE.2014; 9(10): e110368.     CrossRef
  • Protocol for the DREAM Project (Diabetes Research, Education, and Action for Minorities): a randomized trial of a community health worker intervention to improve diabetic management and control among Bangladeshi adults in NYC
    Nadia Islam, Lindsey Riley, Laura Wyatt, S Darius Tandon, Michael Tanner, Runi Mukherji-Ratnam, Mariano Rey, Chau Trinh-Shevrin
    BMC Public Health.2014;[Epub]     CrossRef
  • Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes
    Soo Lim, Jae Hyun Bae, Eun Ju Chun, Haeryoung Kim, So Yeon Kim, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Jose C. Florez, Hak Chul Jang
    Acta Diabetologica.2014; 51(5): 739.     CrossRef
  • Letter: Increasing Prevalence of Type 2 Diabetes in a Rural Bangladeshi Population: A Population Based Study for 10 Years (Diabetes Metab J2013;37:46-53)
    Nan Hee Kim
    Diabetes & Metabolism Journal.2013; 37(2): 152.     CrossRef
Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes
Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Ihn-Ho Cho, Hyoung Woo Lee
Diabetes Metab J. 2013;37(1):54-62.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.54
  • 3,633 View
  • 29 Download
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

A 64-slice multidetector computed tomography (MDCT) is well known to be a useful noninvasive form of angiography for the general population, but not for certain patients with diabetes. The aim of this study was to investigate the diagnostic accuracy and usefulness of 64-slice MDCT coronary angiography for detecting coronary artery disease in Korean patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 240 patients were included, 74 of whom had type 2 diabetes (M:F=40:33; 41.8±9.5 years). We compared significant coronary stenosis (>50% luminal narrowing) in MDCT with invasive coronary angiography (ICA) by segment, artery, and patient. We also evaluated the influence of obesity and coronary calcium score on MDCT accuracy.

Results

Of the 4,064 coronary segments studied, 4,062 segments (T2DM=1,109) were assessed quantitatively by both MDCT and ICA, and 706 segments (T2DM=226) were detected as a significant lesion by ICA in all patients. Sensitivity, specificity, as well as positive and negative predictive values for the presence of significant stenosis in T2DM were: by segment, 89.4%, 96.4%, 85.8%, and 97.4%, respectively; by artery (n=222), 95.1%, 92.9%, 94.4%, and 93.8%, respectively; by patients (n=74), 98.4%, 100.0%, 98.4%, and 90.0%, respectively. Regardless of presence of diabetes, there was no significant difference in diagnostic accuracy. Obesity (≥25 kg/m2) and coronary calcium score did not also affect the diagnostic accuracy of MDCT.

Conclusion

The 64-slice MDCT coronary angiography was found to have similar diagnostic accuracy with ICA, regardless of diabetes. These results suggest MDCT may be helpful to reduce unnecessary invasive studies for patients with diabetes.

Citations

Citations to this article as recorded by  
  • Can Radiation Dose Burden of CT Angiography be Reduced While Still Accurately Diagnosing Etiology of Acute Chest Pain?
    Sherine M. Sharara, Scott R. Monnin, Manolo Rubio, Rami N. Khouzam, Samar R. Ragheb
    Current Problems in Cardiology.2021; 46(4): 100766.     CrossRef
  • Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus
    Hai-Ting Zhou, De-Li Zhao, Guo-Kun Wang, Tian-Zuo Wang, Hong-Wei Liang, Jin-Ling Zhang
    BMC Cardiovascular Disorders.2020;[Epub]     CrossRef
  • Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study
    Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Dong Hyun Yang, Joon-Won Kang, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2020; 10(1): 92.     CrossRef
  • The impact of non-alcoholic fatty liver disease and metabolic syndrome on the progression of coronary artery calcification
    Yun Kyung Cho, Yu Mi Kang, Jee Hee Yoo, Jiwoo Lee, Seung Eun Lee, Dong Hyun Yang, Joon-Won Kang, Joong-Yeol Park, Chang Hee Jung, Hong-Kyu Kim, Woo Je Lee
    Scientific Reports.2018;[Epub]     CrossRef
  • Effects of Low-density Lipoprotein Cholesterol on Coronary Artery Calcification Progression According to High-density Lipoprotein Cholesterol Levels
    Da Young Lee, Ji Hyun Kim, Se Eun Park, Cheol-young Park, Ki-won Oh, Sung-woo Park, Eun-Jung Rhee, Won-young Lee
    Archives of Medical Research.2017; 48(3): 284.     CrossRef
  • 2013 ACC/AHA Cholesterol Guideline Versus 2004 NCEP ATP III Guideline in the Prediction of Coronary Artery Calcification Progression in a Korean Population
    Yun Kyung Cho, Chang Hee Jung, Yu Mi Kang, Jenie Yoonoo Hwang, Eun Hee Kim, Dong Hyun Yang, Joon‐Won Kang, Joong‐Yeol Park, Hong‐Kyu Kim, Woo Je Lee
    Journal of the American Heart Association.2016;[Epub]     CrossRef
  • Imaging Quality Evaluation of Low Tube Voltage Coronary CT Angiography Using Low Concentration Contrast Medium
    Chengzhong Zhang, Yuejun Yu, Zaixian Zhang, Qingguo Wang, Linfeng Zheng, Yan Feng, Zhiguo Zhou, Guixiang Zhang, Kangan Li, Zhuoli Zhang
    PLOS ONE.2015; 10(3): e0120539.     CrossRef
  • 2013 ACC/AHA versus 2004 NECP ATP III Guidelines in the Assignment of Statin Treatment in a Korean Population with Subclinical Coronary Atherosclerosis
    Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Dong Hyun Yang, Joon-Won Kang, Eun Hee Kim, Duk-Woo Park, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee, Yingmei Feng
    PLOS ONE.2015; 10(9): e0137478.     CrossRef
  • Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
    Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
    Diabetes & Metabolism Journal.2015; 39(5): 414.     CrossRef
  • Association between serum gamma-glutamyltransferase and the progression of coronary artery calcification
    Yun Kyung Cho, Yu Mi Kang, Jenie Yoonoo Hwang, Eun Hee Kim, Dong Hyun Yang, Joon-Won Kang, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Atherosclerosis.2015; 243(1): 300.     CrossRef
  • Role of Bilirubin in Diabetic Vascular Complications: Can Bilirubin Predict More than Just Liver Disease?
    Jun Sung Moon
    Diabetes & Metabolism Journal.2015; 39(5): 384.     CrossRef
  • The Association of Rate of Weight Gain During Early Adulthood With the Prevalence of Subclinical Coronary Artery Disease in Recently Diagnosed Type 2 Diabetes: The MAXWEL-CAD Study
    Soo Lim, Sung Hee Choi, Kyoung Min Kim, Sang Il Choi, Eun Ju Chun, Min Joo Kim, Kyong Soo Park, Hak Chul Jang, Naveed Sattar
    Diabetes Care.2014; 37(9): 2491.     CrossRef
  • Retraction: Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes
    Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Ihn-Ho Cho, Hyoung Woo Lee
    Diabetes & Metabolism Journal.2013; 37(3): 217.     CrossRef
Increased Selenoprotein P Levels in Subjects with Visceral Obesity and Nonalcoholic Fatty Liver Disease
Hae Yoon Choi, Soon Young Hwang, Chang Hee Lee, Ho Cheol Hong, Sae Jeong Yang, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Kyung Mook Choi
Diabetes Metab J. 2013;37(1):63-71.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.63
  • 4,879 View
  • 36 Download
  • 85 Crossref
AbstractAbstract PDFPubReader   
Background

Selenoprotein P (SeP) has recently been reported as a novel hepatokine that regulates insulin resistance and systemic energy metabolism in rodents and humans. We explored the associations among SeP, visceral obesity, and nonalcoholic fatty liver disease (NAFLD).

Methods

We examined serum SeP concentrations in subjects with increased visceral fat area (VFA) or liver fat accumulation measured with computed tomography. Our study subjects included 120 nondiabetic individuals selected from participants of the Korean Sarcopenic Obesity Study. In addition, we evaluated the relationship between SeP and cardiometabolic risk factors, including homeostasis model of insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hsCRP), adiponectin values, and brachial-ankle pulse wave velocity (baPWV).

Results

Subjects with NAFLD showed increased levels of HOMA-IR, hsCRP, VFA, and several components of metabolic syndrome and decreased levels of adiponectin and high density lipoprotein cholesterol than those of controls. Serum SeP levels were positively correlated with VFA, hsCRP, and baPWV and negatively correlated with the liver attenuation index. Not only subjects with visceral obesity but also those with NAFLD exhibited significantly increased SeP levels (P<0.001). In multiple logistic regression analysis, the subjects in the highest SeP tertile showed a higher risk for NAFLD than those in the lowest SeP tertile, even after adjusting for potential confounding factors (odds ratio, 7.48; 95% confidence interval, 1.72 to 32.60; P=0.007).

Conclusion

Circulating SeP levels were increased in subjects with NAFLD as well as in those with visceral obesity and may be a novel biomarker for NAFLD.

Citations

Citations to this article as recorded by  
  • Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease
    Guillaume Henin, Audrey Loumaye, Isabelle A. Leclercq, Nicolas Lanthier
    JHEP Reports.2024; 6(2): 100963.     CrossRef
  • Association between serum trace element, mineral, and amino acid levels with non-alcoholic fatty liver disease (NAFLD) in adult women
    Alexey A. Tinkov, Tatiana V. Korobeinikova, Galina D. Morozova, Michael Aschner, Daria V. Mak, Abel Santamaria, Joao B.T. Rocha, Tatiana I. Sotnikova, Serafima Ia. Tazina, Anatoly V. Skalny
    Journal of Trace Elements in Medicine and Biology.2024; 83: 127397.     CrossRef
  • Adipose-derived extracellular vesicles – a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome
    Dušan Mladenović, Milena Vesković, Nikola Šutulović, Dragan Hrnčić, Olivera Stanojlović, Lena Radić, Jelica Bjekić Macut, Djuro Macut
    Endocrine.2024;[Epub]     CrossRef
  • Association of metabolic-dysfunction associated steatotic liver disease with polycystic ovary syndrome
    Qiuyu Xu, Jie Zhang, Yan Lu, Ling Wu
    iScience.2024; 27(2): 108783.     CrossRef
  • The role of hepatokines in NAFLD
    Norbert Stefan, Fritz Schick, Andreas L. Birkenfeld, Hans-Ulrich Häring, Morris F. White
    Cell Metabolism.2023; 35(2): 236.     CrossRef
  • The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease
    Li Qin, Junru Wu, Xuejing Sun, Xuewei Huang, Wei Huang, Chunyan Weng, Jingjing Cai
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • The Role of Organokines in Obesity and Type 2 Diabetes and Their Functions as Molecular Transducers of Nutrition and Exercise
    Ji Ye Lim, Eunju Kim
    Metabolites.2023; 13(9): 979.     CrossRef
  • Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study
    Aikaterini Giannouli, Charikleia Stefanaki, Christos Kouskoutis, Marianna Konidari, Iliana Mani, Konstantina Konidari, Sophia L. Markantonis, Aimilia Mantzou, Spyridon P. Dourakis, Efthymios Deligeoroglou, Flora Bacopoulou
    Journal of Clinical Medicine.2023; 12(17): 5744.     CrossRef
  • The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach
    Milena Vesković, Nikola Šutulović, Dragan Hrnčić, Olivera Stanojlović, Djuro Macut, Dušan Mladenović
    Current Issues in Molecular Biology.2023; 45(11): 9084.     CrossRef
  • Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2
    Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito
    Communications Biology.2023;[Epub]     CrossRef
  • “Alphabet” Selenoproteins: Implications in Pathology
    Carmen Beatrice Dogaru, Carmen Duță, Corina Muscurel, Irina Stoian
    International Journal of Molecular Sciences.2023; 24(20): 15344.     CrossRef
  • Metabolic dysfunction-associated steatotic liver disease and the heart
    Stan Driessen, Sven M. Francque, Stefan D. Anker, Manuel Castro Cabezas, Diederick E. Grobbee, Maarten E. Tushuizen, Adriaan G. Holleboom
    Hepatology.2023;[Epub]     CrossRef
  • Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis
    Ruirui Yu, Zhoutian Wang, Miaomiao Ma, Ping Xu, Longjian Liu, Alexey A. Tinkov, Xin Gen Lei, Ji-Chang Zhou
    Antioxidants.2022; 11(7): 1263.     CrossRef
  • Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
    Meenakshi Vachher, Savita Bansal, Bhupender Kumar, Sandeep Yadav, Taruna Arora, Nalini Moza Wali, Archana Burman
    Journal of Cellular Biochemistry.2022; 123(10): 1553.     CrossRef
  • Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis
    Bing Yang, Liqing Lu, Dongmei Zhou, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Heping Yang, Xi Yang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Cytokines and regulation of glucose and lipid metabolism in the obesity
    V. I. Scherbakov, G. A. Skosyreva, T. I. Ryabichenko, O. O. Obukhova
    Obesity and metabolism.2022; 19(3): 317.     CrossRef
  • SeP is elevated in NAFLD and participates in NAFLD pathogenesis through AMPK/ACC pathway
    Yi Chen, Xinjue He, Xueyang Chen, Youming Li, Yini Ke
    Journal of Cellular Physiology.2021; 236(5): 3800.     CrossRef
  • Hepatokines and metabolism: Deciphering communication from the liver
    Sharon O. Jensen-Cody, Matthew J. Potthoff
    Molecular Metabolism.2021; 44: 101138.     CrossRef
  • Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD
    Sechang Oh, Takehiko Tsujimoto, Bokun Kim, Fumihiko Uchida, Hideo Suzuki, Seiichiro Iizumi, Tomonori Isobe, Takeji Sakae, Kiyoji Tanaka, Junichi Shoda
    JHEP Reports.2021; 3(3): 100253.     CrossRef
  • Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy
    Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S. Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke R. Sweeney, Alec Friesen, Jason D. Fraser, Valentina Shakhnovich
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association of Urinary and Dietary Selenium and of Serum Selenium Species with Serum Alanine Aminotransferase in a Healthy Italian Population
    Teresa Urbano, Tommaso Filippini, Daniela Lasagni, Tiziana De Luca, Peter Grill, Sabrina Sucato, Elisa Polledri, Guy Djeukeu Noumbi, Marcella Malavolti, Annalisa Santachiara, Thelma A. Pertinhez, Roberto Baricchi, Silvia Fustinoni, Bernhard Michalke, Marc
    Antioxidants.2021; 10(10): 1516.     CrossRef
  • Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
    Kaitlin Day, Lucia A. Seale, Ross M. Graham, Barbara R. Cardoso
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism
    Tae Hyun Kim, Dong-Gyun Hong, Yoon Mee Yang
    Biomedicines.2021; 9(12): 1903.     CrossRef
  • Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis
    Jarosław Jerzy Sak, Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Ewa Kurys-Denis, Hanna Bis-Wencel
    World Journal of Hepatology.2021; 13(12): 2071.     CrossRef
  • Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men
    Scott A Willis, Jack A Sargeant, Thomas Yates, Toshinari Takamura, Hiroaki Takayama, Vinay Gupta, Emily Brittain, Joe Crawford, Siôn A Parry, Alice E Thackray, Veronica Varela-Mato, David J Stensel, Rachel M Woods, Carl J Hulston, Guruprasad P Aithal, Jam
    The Journal of Nutrition.2020; 150(5): 1076.     CrossRef
  • Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity
    Hung‐Tsung Wu, Szu‐Chi Chen, Kang‐Chih Fan, Chun‐Heng Kuo, Shin‐Yu Lin, Shu‐Huei Wang, Chih‐Jen Chang, Hung‐Yuan Li
    The FASEB Journal.2020; 34(2): 2958.     CrossRef
  • Nonalcoholic fatty liver disease and cardiovascular disease phenotypes
    Giandomenico Bisaccia, Fabrizio Ricci, Cesare Mantini, Claudio Tana, Gian Luca Romani, Cosima Schiavone, Sabina Gallina
    SAGE Open Medicine.2020; 8: 205031212093380.     CrossRef
  • Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis
    Anna Baran, Julia Nowowiejska, Julita Anna Krahel, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak
    International Journal of Molecular Sciences.2020; 21(13): 4594.     CrossRef
  • The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
    Adrian M. Gonzalez-Gil, Leticia Elizondo-Montemayor
    Nutrients.2020; 12(6): 1899.     CrossRef
  • Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More
    Ryouhei Tsutsumi, Yoshiro Saito
    Biological and Pharmaceutical Bulletin.2020; 43(3): 366.     CrossRef
  • Selenium and selenoprotein P in nonalcoholic fatty liver disease
    Stergios A. Polyzos, Jannis Kountouras, Antonis Goulas, Leonidas Duntas
    Hormones.2020; 19(1): 61.     CrossRef
  • The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet
    Pengzu Wang, Zhuang Lu, Meng He, Baoming Shi, Xingen Lei, Anshan Shan
    Nutrients.2020; 12(3): 692.     CrossRef
  • The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease
    Young Mi Jung, Seung Mi Lee, Subeen Hong, Ja Nam Koo, Ig Hwan Oh, Byoung Jae Kim, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Sue Shin, Errol R. Norwitz, Chan‐Wook Park, Jong Kwan Jun, Won Kim, Joong Shin Park
    Liver International.2020; 40(10): 2417.     CrossRef
  • Why Multiples of 21? Why does Selenoprotein P Contain Multiple Selenocysteine Residues?
    Janinah Baclaocos, John James Mackrill
    Current Nutraceuticals.2020; 1(1): 42.     CrossRef
  • Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity
    Alexey A. Tinkov, Olga P. Ajsuvakova, Tommaso Filippini, Ji-Chang Zhou, Xin Gen Lei, Eugenia R. Gatiatulina, Bernhard Michalke, Margarita G. Skalnaya, Marco Vinceti, Michael Aschner, Anatoly V. Skalny
    Biomolecules.2020; 10(4): 658.     CrossRef
  • Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines
    Justine Faramia, Giada Ostinelli, Virginie Drolet-Labelle, Frédéric Picard, André Tchernof
    Current Opinion in Pharmacology.2020; 52: 67.     CrossRef
  • Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)
    David Carneros, Guillermo López-Lluch, Matilde Bustos
    Nutrients.2020; 12(11): 3472.     CrossRef
  • Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P
    Gian Paolo Caviglia, Chiara Rosso, Angelo Armandi, Melania Gaggini, Fabrizia Carli, Maria Lorena Abate, Antonella Olivero, Davide Giuseppe Ribaldone, Giorgio Maria Saracco, Amalia Gastaldelli, Elisabetta Bugianesi
    International Journal of Molecular Sciences.2020; 21(22): 8838.     CrossRef
  • Can hepatokines be regarded as novel non-invasive serum biomarkers of intrahepatic lipid content in obese children?
    Marta Flisiak-Jackiewicz, Anna Bobrus-Chociej, Natalia Wasilewska, Eugeniusz Tarasow, Malgorzata Wojtkowska, Dariusz Marek Lebensztejn
    Advances in Medical Sciences.2019; 64(2): 280.     CrossRef
  • Dietary pattern associated with selenoprotein P and MRI-derived body fat volumes, liver signal intensity, and metabolic disorders
    Romina di Giuseppe, Sandra Plachta-Danielzik, Manja Koch, Ute Nöthlings, Sabrina Schlesinger, Jan Borggrefe, Marcus Both, Hans-Peter Müller, Jan Kassubek, Gunnar Jacobs, Wolfgang Lieb
    European Journal of Nutrition.2019; 58(3): 1067.     CrossRef
  • Cytokines and Abnormal Glucose and Lipid Metabolism
    Jie Shi, Jiangao Fan, Qing Su, Zhen Yang
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Role of exercise-induced hepatokines in metabolic disorders
    Gaël Ennequin, Pascal Sirvent, Martin Whitham
    American Journal of Physiology-Endocrinology and Metabolism.2019; 317(1): E11.     CrossRef
  • Metabolomics signature associated with circulating serum selenoprotein P levels
    Romina di Giuseppe, Manja Koch, Ute Nöthlings, Gabi Kastenmüller, Anna Artati, Jerzy Adamski, Gunnar Jacobs, Wolfgang Lieb
    Endocrine.2019; 64(3): 486.     CrossRef
  • Secretomics to Discover Regulators in Diseases
    Parkyong Song, Yonghoon Kwon, Jae-Yeol Joo, Do-Geun Kim, Jong Hyuk Yoon
    International Journal of Molecular Sciences.2019; 20(16): 3893.     CrossRef
  • Impact of Lipotoxicity on Tissue “Cross Talk” and Metabolic Regulation
    Magdalene K. Montgomery, William De Nardo, Matthew J. Watt
    Physiology.2019; 34(2): 134.     CrossRef
  • The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
    Matthew J Watt, Paula M Miotto, William De Nardo, Magdalene K Montgomery
    Endocrine Reviews.2019; 40(5): 1367.     CrossRef
  • Inter-organ cross-talk in metabolic syndrome
    Christina Priest, Peter Tontonoz
    Nature Metabolism.2019; 1(12): 1177.     CrossRef
  • Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population
    Swe Mar Oo, Hirofumi Misu, Yoshiro Saito, Mutsumi Tanaka, Seiji Kato, Yuki Kita, Hiroaki Takayama, Yumie Takeshita, Takehiro Kanamori, Toru Nagano, Masatoshi Nakagen, Takeshi Urabe, Naoto Matsuyama, Shuichi Kaneko, Toshinari Takamura
    Scientific Reports.2018;[Epub]     CrossRef
  • NAFLD and cardiovascular disease
    Elisabete Martins, Ana Oliveira
    Porto Biomedical Journal.2018; 3(2): e2.     CrossRef
  • The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men
    Jack A. Sargeant, Guruprasad P. Aithal, Toshinari Takamura, Hirofumi Misu, Hiroaki Takayama, Jessica A. Douglas, Mark C. Turner, David J. Stensel, Myra A. Nimmo, David R. Webb, Thomas Yates, James A. King
    Applied Physiology, Nutrition, and Metabolism.2018; 43(5): 482.     CrossRef
  • Low Urine pH Is Associated with Non-alcoholic Fatty Liver Disease: A Community-based Cross-sectional Study
    Teruki Miyake, Sakiko Yoshida, Shin Yamamoto, Shinya Furukawa, Osamu Yoshida, Sayaka Kanzaki, Hidenori Senba, Toru Ishihara, Mitsuhito Koizumi, Yoshio Tokumoto, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
    Internal Medicine.2018; 57(19): 2799.     CrossRef
  • Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation
    Ibrahim Cetindağlı, Muammer Kara, Alpaslan Tanoglu, Veysel Ozalper, Serkan Aribal, Yusuf Hancerli, Mehmet Unal, Onur Ozarı, Serdar Hira, Mustafa Kaplan, Yusuf Yazgan
    Clinics and Research in Hepatology and Gastroenterology.2017; 41(5): 516.     CrossRef
  • Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels
    Teruki Miyake, Masashi Hirooka, Osamu Yoshida, Shinya Furukawa, Teru Kumagi, Mitsuhito Koizumi, Shin Yamamoto, Taira Kuroda, Eiji Arimitsu, Eiji Takeshita, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
    Journal of Gastroenterology.2017; 52(2): 237.     CrossRef
  • Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
    Ruth C. R. Meex, Matthew J. Watt
    Nature Reviews Endocrinology.2017; 13(9): 509.     CrossRef
  • Circulating selenoprotein P levels in relation to MRI‐derived body fat volumes, liver fat content, and metabolic disorders
    Romina di Giuseppe, Manja Koch, Sabrina Schlesinger, Jan Borggrefe, Marcus Both, Hans‐Peter Müller, Jan Kassubek, Gunnar Jacobs, Ute Nöthlings, Wolfgang Lieb
    Obesity.2017; 25(6): 1128.     CrossRef
  • Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes
    Natsumi Tajima-Shirasaki, Kiyo-aki Ishii, Hiroaki Takayama, Takayoshi Shirasaki, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Yasumasa Iwasaki, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Yumie Takeshita, Koji Murao, Seiichi Matsugo, Shuichi Kaneko, H
    Journal of Biological Chemistry.2017; 292(26): 10791.     CrossRef
  • Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance
    Miaoxin Chen, Bo Liu, David Wilkinson, Amy T. Hutchison, Campbell H. Thompson, Gary A. Wittert, Leonie K. Heilbronn
    Obesity Research & Clinical Practice.2017; 11(2): 227.     CrossRef
  • Cardiovascular Risk in Patients with Non-alcoholic Fatty Liver Disease
    Hak Soo Kim, Yong Kyun Cho
    The Korean Journal of Gastroenterology.2017; 69(6): 333.     CrossRef
  • Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies
    Yong-ho Lee, Sang-Guk Lee, Chan Joo Lee, Soo Hyun Kim, Young-Mi Song, Mi Ra Yoon, Byung Hun Jeon, Jae Hyuk Lee, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong-Soo Cha
    Scientific Reports.2016;[Epub]     CrossRef
  • Implication of hepatokines in metabolic disorders and cardiovascular diseases
    Tae Woo Jung, Hye Jin Yoo, Kyung Mook Choi
    BBA Clinical.2016; 5: 108.     CrossRef
  • Selenoproteins: Antioxidant selenoenzymes and beyond
    Holger Steinbrenner, Bodo Speckmann, Lars-Oliver Klotz
    Archives of Biochemistry and Biophysics.2016; 595: 113.     CrossRef
  • Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines
    Kyoung-Jin Oh, Da Lee, Won Kim, Baek Han, Sang Lee, Kwang-Hee Bae
    International Journal of Molecular Sciences.2016; 18(1): 8.     CrossRef
  • Pathogenesis of nonalcoholic steatohepatitis
    Wensheng Liu, Robert D. Baker, Tavleen Bhatia, Lixin Zhu, Susan S. Baker
    Cellular and Molecular Life Sciences.2016; 73(10): 1969.     CrossRef
  • Stéatose et résistance à l’insuline : implication des hépatokines
    C. Bertrand, P. Valet, I. Castan-Laurell
    Obésité.2016; 11(3): 170.     CrossRef
  • Pathophysiology of Non Alcoholic Fatty Liver Disease
    Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino
    International Journal of Molecular Sciences.2016; 17(12): 2082.     CrossRef
  • Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study
    Sahar A. Ali, Walaa M.H. Nassif, Dalia H.A. Abdelaziz
    Clinics and Research in Hepatology and Gastroenterology.2016; 40(4): 465.     CrossRef
  • Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
    Sven M. Francque, Denise van der Graaff, Wilhelmus J. Kwanten
    Journal of Hepatology.2016; 65(2): 425.     CrossRef
  • “Omics” of Selenium Biology: A Prospective Study of Plasma Proteome Network Before and After Selenized-Yeast Supplementation in Healthy Men
    Indu Sinha, Kubra Karagoz, Rachel L. Fogle, Christopher S. Hollenbeak, Arnold H. Zea, Kazim Y. Arga, Anne E. Stanley, Wayne C. Hawkes, Raghu Sinha
    OMICS: A Journal of Integrative Biology.2016; 20(4): 202.     CrossRef
  • Nonalcoholic steatohepatitis is strongly associated with sarcopenic obesity in patients with cirrhosis undergoing liver transplant evaluation
    Sandra Carias, Ana Lia Castellanos, Valery Vilchez, Rashmi Nair, Anna Christina Dela Cruz, Jennifer Watkins, Terrence Barrett, Patel Trushar, Karyn Esser, Roberto Gedaly
    Journal of Gastroenterology and Hepatology.2016; 31(3): 628.     CrossRef
  • Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes
    Sofiya Gancheva, Alessandra Bierwagen, Kirti Kaul, Christian Herder, Peter Nowotny, Sabine Kahl, Guido Giani, Birgit Klueppelholz, Birgit Knebel, Paul Begovatz, Klaus Strassburger, Hadi Al-Hasani, Jesper Lundbom, Julia Szendroedi, Michael Roden
    Diabetes.2016; 65(7): 1849.     CrossRef
  • Selenoprotein P is not elevated in gestational diabetes mellitus
    Alev E. Altinova, Ozlem T. Iyidir, Cigdem Ozkan, Damla Ors, Merve Ozturk, Ozlem Gulbahar, Nuray Bozkurt, Fusun B. Toruner, Mujde Akturk, Nuri Cakir, Metin Arslan
    Gynecological Endocrinology.2015; 31(11): 874.     CrossRef
  • Selenium and Human Health: Witnessing a Copernican Revolution?
    Ewa Jablonska, Marco Vinceti
    Journal of Environmental Science and Health, Part C.2015; 33(3): 328.     CrossRef
  • Toenail selenium and risk of type 2 diabetes: the ORDET cohort study
    Marco Vinceti, Sara Grioni, Dorothea Alber, Dario Consonni, Carlotta Malagoli, Claudia Agnoli, Marcella Malavolti, Valeria Pala, Vittorio Krogh, Sabina Sieri
    Journal of Trace Elements in Medicine and Biology.2015; 29: 145.     CrossRef
  • Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet
    Hua Zhao, Ke Li, Jia-Yong Tang, Ji-Chang Zhou, Kang-Ning Wang, Xin-Jie Xia, Xin Gen Lei
    The Journal of Nutrition.2015; 145(7): 1394.     CrossRef
  • Hepatokines as a Link between Obesity and Cardiovascular Diseases
    Hye Jin Yoo, Kyung Mook Choi
    Diabetes & Metabolism Journal.2015; 39(1): 10.     CrossRef
  • The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice
    Takayasu Ideta, Yohei Shirakami, Tsuneyuki Miyazaki, Takahiro Kochi, Hiroyasu Sakai, Hisataka Moriwaki, Masahito Shimizu
    International Journal of Molecular Sciences.2015; 16(12): 29207.     CrossRef
  • Dietary selenate attenuates adiposity and improves insulin sensitivity in high-fat diet-induced obese mice
    Choon Young Kim, Yuyan Zhu, Kimberly K. Buhman, Kee-Hong Kim
    Journal of Functional Foods.2015; 17: 33.     CrossRef
  • Use of a Diabetes Self-Assessment Score to Predict Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
    Gyuri Kim, Yong-ho Lee, Young Min Park, Jungghi Kim, Heesuk Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Dae Jung Kim
    Medicine.2015; 94(27): e1103.     CrossRef
  • Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells
    Sattar Gorgani-Firuzjaee, Khosrow Adeli, Reza Meshkani
    Biochemical and Biophysical Research Communications.2015; 464(2): 441.     CrossRef
  • Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK
    Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    Endocrinology and Metabolism.2015; 30(2): 177.     CrossRef
  • AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes
    Tae Woo Jung, So Young Lee, Ho Cheol Hong, Hae Yoon Choi, Hye Jin Yoo, Sei Hyun Baik, Kyung Mook Choi
    Molecular and Cellular Endocrinology.2014; 382(1): 66.     CrossRef
  • HIF‐1α Expression as a Protective Strategy of HepG2 Cells Against Fatty Acid‐Induced Toxicity
    Wonbaek Yoo, Kyung Hee Noh, Jae Hee Ahn, Ji Hee Yu, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Tae Woo Kim, Hyo Joon Kim, Nan Hee Kim
    Journal of Cellular Biochemistry.2014; 115(6): 1147.     CrossRef
  • Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics
    Jacklyn N. Hellwege, Nicholette D. Palmer, Julie T. Ziegler, Carl D. Langefeld, Carlos Lorenzo, Jill M. Norris, Toshinari Takamura, Donald W. Bowden
    Gene.2014; 534(1): 33.     CrossRef
  • Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children
    B-J Ko, S M Kim, K H Park, H S Park, C S Mantzoros
    International Journal of Obesity.2014; 38(12): 1497.     CrossRef
  • The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels
    Kyung-Soo Kim, Hyun-Ju Oh, Dae-Jung Kim, Soo-Kyung Kim, Seok Won Park, Yong-Wook Cho, Kap-Bum Huh
    Endocrine Journal.2013; 60(12): 1295.     CrossRef
Predictive Clinical Parameters and Glycemic Efficacy of Vildagliptin Treatment in Korean Subjects with Type 2 Diabetes
Jin-Sun Chang, Juyoung Shin, Hun-Sung Kim, Kyung-Hee Kim, Jeong-Ah Shin, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son, Jae-Hyoung Cho
Diabetes Metab J. 2013;37(1):72-80.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.72
  • 3,698 View
  • 31 Download
  • 2 Crossref
AbstractAbstract PDFPubReader   
Background

The aims of this study are to investigate the glycemic efficacy and predictive parameters of vildagliptin therapy in Korean subjects with type 2 diabetes.

Methods

In this retrospective study, we retrieved data for subjects who were on twice-daily 50 mg vildagliptin for at least 6 months, and classified the subjects into five treatment groups. In three of the groups, we added vildagliptin to their existing medication regimen; in the other two groups, we replaced one of their existing medications with vildagliptin. We then analyzed the changes in glucose parameters and clinical characteristics.

Results

Ultimately, 327 subjects were analyzed in this study. Vildagliptin significantly improved hemoglobin A1c (HbA1c) levels over 6 months. The changes in HbA1c levels (ΔHbA1c) at month 6 were -2.24% (P=0.000), -0.77% (P=0.000), -0.80% (P=0.001), -0.61% (P=0.000), and -0.34% (P=0.025) for groups 1, 2, 3, 4, and 5, respectively, with significance. We also found significant decrements in fasting plasma glucose levels in groups 1, 2, 3, and 4 (P<0.05). Of the variables, initial HbA1c levels (P=0.032) and history of sulfonylurea use (P=0.026) were independently associated with responsiveness to vildagliptin treatment.

Conclusion

Vildagliptin was effective when it was used in subjects with poor glycemic control. It controlled fasting plasma glucose levels as well as sulfonylurea treatment in Korean type 2 diabetic subjects.

Citations

Citations to this article as recorded by  
  • Predictive clinical parameters for the hemoglobin A1c-lowering effect of vildagliptin in Japanese patients with type 2 diabetes
    Yukihiro Bando, Masayuki Yamada, Keiko Aoki, Hideo Kanehara, Azusa Hisada, Kazuhiro Okafuji, Daisyu Toya, Nobuyoshi Tanaka
    Diabetology International.2014; 5(4): 229.     CrossRef
  • The Efficacy of Vildagliptin in Korean Patients with Type 2 Diabetes
    Jun Sung Moon, Kyu Chang Won
    Diabetes & Metabolism Journal.2013; 37(1): 36.     CrossRef
Letter
Letter: The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone (Diabetes Metab J 2012;36:371-8)
Sheyu Li, Haoming Tian
Diabetes Metab J. 2013;37(1):81-82.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.81
  • 2,605 View
  • 30 Download
  • 2 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future
    Melissa A. Davidson, Donald R. Mattison, Laurent Azoulay, Daniel Krewski
    Critical Reviews in Toxicology.2018; 48(1): 52.     CrossRef
  • Pioglitazone
    SS Jadhav, VK Shivane, AR Lila, TR Bandgar, NS Shah
    Journal of Postgraduate Medicine.2014; 60(3): 293.     CrossRef
Response
Response: The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone (Diabetes Metab J 2012;36:371-8)
Kwang Joon Kim, Sun Ok Song, Byung-Wan Lee
Diabetes Metab J. 2013;37(1):83-84.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.83
  • 2,922 View
  • 27 Download
PDFPubReader   

Diabetes Metab J : Diabetes & Metabolism Journal