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Volume 36(3); June 2012
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Retinoid Metabolism and Diabetes Mellitus
Eun-Jung Rhee, Jorge Plutzky
Diabetes Metab J. 2012;36(3):167-180.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.167
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  • 64 Download
  • 52 Crossref
AbstractAbstract PDFPubReader   

Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders. Given the special concern over the recent increase in the prevalence of diabetes worldwide, the role of retinoid metabolism on glucose metabolism and insulin resistance in the human body is of marked importance. Therefore, in this issue, we review the literature on the association of retinoid metabolism with glucose tolerance, with regard to insulin secretion, pancreatic autoimmunity, insulin sensitivity and lipid metabolism. Further, we tried to assess the possibility of using retinoids as a novel therapeutic strategy for diabetes.

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Citations to this article as recorded by  
  • Dysregulated cysteine metabolism leads to worsened liver pathology in diabetes-tuberculosis comorbid condition
    Shweta Chaudhary, Falak Pahwa, Ranjan K. Nanda
    Journal of Biological Chemistry.2024; 300(2): 105634.     CrossRef
  • Role of dietary antioxidants in diabetes: An overview
    Mohamed Shafras, Rasangi Sabaragamuwa, Mohamed Suwair
    Food Chemistry Advances.2024; 4: 100666.     CrossRef
  • Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults
    Casper S. Poulsen, Dan Hesse, Gabriel R. Fernandes, Tue H. Hansen, Timo Kern, Allan Linneberg, Lore Van Espen, Torben Jørgensen, Trine Nielsen, Amra C. Alibegovic, Jelle Matthijnssens, Oluf Pedersen, Henrik Vestergaard, Torben Hansen, Mette K. Andersen
    Scientific Reports.2024;[Epub]     CrossRef
  • Retinoic acid signaling is critical for generation of pancreatic progenitors from human embryonic stem cells
    Niloufer P. Dumasia, Aparna P. Khanna, Prasad S. Pethe
    Growth Factors.2023; 41(1): 8.     CrossRef
  • Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection
    Alexis Yero, Ralph-Sydney Mboumba Bouassa, Petronela Ancuta, Jerome Estaquier, Mohammad-Ali Jenabian
    Cytokine & Growth Factor Reviews.2023; 69: 1.     CrossRef
  • The transcriptomic and epigenetic alterations in type 2 diabetes mellitus patients of Chinese Tibetan and Han populations
    Xian Wang, Jie Liu, Qiuhong Wang, Qiu Chen
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Pericytes modulate islet immune cells and insulin secretion through Interleukin-33 production in mice
    Guzel Burganova, Anat Schonblum, Lina Sakhneny, Alona Epshtein, Tomer Wald, Mika Tzaig, Limor Landsman
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry
    Wasim Akram, Mohd Rihan, Sakeel Ahmed, Swamita Arora, Sameer Ahmad, Rahul Vashishth
    Marine Drugs.2023; 21(3): 193.     CrossRef
  • Metabolite Profiling of the Gut–Renal–Cerebral Axis Reveals a Particular Pattern in Early Diabetic Kidney Disease in T2DM Patients
    Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Ligia Petrica
    International Journal of Molecular Sciences.2023; 24(7): 6212.     CrossRef
  • Multimodal plasma metabolomics and lipidomics in elucidating metabolic perturbations in tuberculosis patients with concurrent type 2 diabetes
    Nguyen Thi Hai Yen, Nguyen Ky Anh, Rannissa Puspita Jayanti, Nguyen Ky Phat, Dinh Hoa Vu, Jong-Lyul Ghim, Sangzin Ahn, Jae-Gook Shin, Jee Youn Oh, Nguyen Phuoc Long, Dong Hyun Kim
    Biochimie.2023; 211: 153.     CrossRef
  • Microbiota dysbiosis associated with type 2 diabetes-like effects caused by chronic exposure to a mixture of chlorinated persistent organic pollutants in zebrafish
    Hyojin Lee, Sojeong Yoon, Youngja Hwang Park, Jeong-Soo Lee, Dong Young Rhyu, Ki-Tae Kim
    Environmental Pollution.2023; 334: 122108.     CrossRef
  • Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis
    Hanyu Yang, Mengxiang Su, Ming Liu, Yun Sheng, Liang Zhu, Lu Yang, Ruijing Mu, Jianjun Zou, Xiaodong Liu, Li Liu
    Acta Pharmaceutica Sinica B.2023; 13(9): 3728.     CrossRef
  • The Association and Mediating Biomarkers of Serum Retinol in Influencing the Development of Type 2 Diabetes: A Prospective Cohort Study in Middle-Aged and Elderly Population
    Xiuyu Pang, Sen Yang, Xiaoyu Guo, Hongyin Li, Yingfeng Zhang, Chunbo Wei, Yu Wang, Changhao Sun, Ying Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Quantification of All-Trans Retinoic Acid by Liquid Chromatography–Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes
    Jakob Morgenstern, Thomas Fleming, Elisabeth Kliemank, Maik Brune, Peter Nawroth, Andreas Fischer
    Metabolites.2021; 11(1): 60.     CrossRef
  • Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects
    Yunting Zhou, Huiying Wang, Junming Zhou, Shanhu Qiu, Tingting Cai, Huiqin Li, Ziyang Shen, Yun Hu, Bo Ding, Menghui Luo, Rong Huang, Rengna Yan, Wei Xu, Cong He, Yumin Zhang, Fengfei Li, Zilin Sun, Jianhua Ma
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association between Vitamin A, E and Type 2 Diabetes Mellitus in Korea: Korean National Health and Nutrition Examination Survey 2016–2018
    Kyungpyo Kim, Junho Choi, Serng Bai Pak
    Korean Journal of Family Practice.2021; 11(2): 135.     CrossRef
  • Serum Retinal and Retinoic Acid Predict the Development of Type 2 Diabetes Mellitus in Korean Subjects with Impaired Fasting Glucose from the KCPS-II Cohort
    Youngmin Han, Yeunsoo Yang, Minjoo Kim, Sun Ha Jee, Hye Jin Yoo, Jong Ho Lee
    Metabolites.2021; 11(8): 510.     CrossRef
  • The Interactions of Insulin and Vitamin A Signaling Systems for the Regulation of Hepatic Glucose and Lipid Metabolism
    Guoxun Chen
    Cells.2021; 10(8): 2160.     CrossRef
  • RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth
    Xiulin Jiang, Yaomei He, Qiushuo Shen, Lincan Duan, Yixiao Yuan, Lin Tang, Yulin Shi, Baiyang Liu, Haoqing Zhai, Peng Shi, Cuiping Yang, Yongbin Chen
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Research Progress in Vitamin A and Autism Spectrum Disorder
    Zhonghui Liu, Jingyu Wang, Qu Xu, Qin Hong, Jiansheng Zhu, Xia Chi, Enzo Emanuele
    Behavioural Neurology.2021; 2021: 1.     CrossRef
  • Reductive Effect of Acitretin on Blood Glucose Levels in Chinese Patients With Psoriasis
    Hua Qian, Yehong Kuang, Juan Su, Menglin Chen, Xiang Chen, Chengzhi Lv, Wangqing Chen, Wu Zhu
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin
    Claudie Dhuique-Mayer, Laura Gence, Karine Portet, Didier Tousch, Patrick Poucheret
    Food & Function.2020; 11(10): 9263.     CrossRef
  • CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease
    Joseph T. Glessner, Jin Li, Akshatha Desai, Melody Palmer, Dokyoon Kim, Anastasia Marie Lucas, Xiao Chang, John J. Connolly, Berta Almoguera, John B. Harley, Gail P. Jarvik, Marylyn D. Ritchie, Patrick M.A. Sleiman, Dan M. Roden, David Crosslin, Hakon Hak
    International Journal of Cardiology.2020; 298: 107.     CrossRef
  • Pancreatic stellate cell‐potentiated insulin secretion from Min6 cells is independent of interleukin 6‐mediated pathway
    Ratnakar R. Bynigeri, Sasikala Mitnala, Rupjyoti Talukdar, Surya S. Singh, Nageshwar R. Duvvuru
    Journal of Cellular Biochemistry.2020; 121(1): 840.     CrossRef
  • Impaired CPT1A Gene Expression Response to Retinoic Acid Treatment in Human PBMC as Predictor of Metabolic Risk
    Margalida Cifre, Andreu Palou, Paula Oliver
    Nutrients.2020; 12(8): 2269.     CrossRef
  • All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage
    Ahmad Alatshan, Gergő E. Kovács, Azzam Aladdin, Zsolt Czimmerer, Krisztina Tar, Szilvia Benkő
    Cells.2020; 9(7): 1591.     CrossRef
  • Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients
    Lina Quteineh, Agnieszka Wójtowicz, Pierre-Yves Bochud, Severine Crettol, Frederik Vandenberghe, Jean-Pierre Venetz, Oriol Manuel, Dela Golshayan, Roger Lehmann, Nicolas J. Mueller, Isabelle Binet, Christian van Delden, Jürg Steiger, Paul Mohacsi, Jean-Fr
    American Journal of Transplantation.2019; 19(1): 238.     CrossRef
  • Vitamin A and Wound Healing
    Roman Zinder, Rachel Cooley, Lucian G. Vlad, Joseph A. Molnar
    Nutrition in Clinical Practice.2019; 34(6): 839.     CrossRef
  • In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring
    Javier Esteban, Marina Serrano-Maciá, Ismael Sánchez-Pérez, Paloma Alonso-Magdalena, María de la Cruz Pellín, Marta García-Arévalo, Ángel Nadal, Jose Barril
    Food and Chemical Toxicology.2019; 126: 142.     CrossRef
  • Risk variants disrupting enhancers of T H 1 and T REG cells in type 1 diabetes
    Peng Gao, Yasin Uzun, Bing He, Sarah E. Salamati, Julie K. M. Coffey, Eva Tsalikian, Kai Tan
    Proceedings of the National Academy of Sciences.2019; 116(15): 7581.     CrossRef
  • Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
    Mónika Sztretye, Beatrix Dienes, Mónika Gönczi, Tamás Czirják, László Csernoch, László Dux, Péter Szentesi, Anikó Keller-Pintér
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease
    Eleonora Scorletti, Paul R. Afolabi, Elizabeth A. Miles, Debbie E. Smith, Amal Almehmadi, Albandri Alshathry, Helen E. Moyses, Geraldine F. Clough, Mark Wright, Janisha Patel, Laure Bindels, Nathalie M. Delzenne, Philip C. Calder, Christopher D. Byrne
    Contemporary Clinical Trials.2018; 71: 113.     CrossRef
  • Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats
    Asdrubal Aguilera-Mendez, María G. Hernández-Equihua, Alfonso C. Rueda-Rocha, Clotilde Guajardo-López, Renato Nieto-Aguilar, Deyanira Serrato-Ochoa, León F. Ruíz Herrera, José A. Guzmán-Nateras
    Nutrition Research.2018; 57: 86.     CrossRef
  • Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
    Nicola Morrice, George D. Mcilroy, Seshu R. Tammireddy, Jennifer Reekie, Kirsty D. Shearer, Mary K. Doherty, Mirela Delibegović, Phillip D. Whitfield, Nimesh Mody
    Scientific Reports.2017;[Epub]     CrossRef
  • Vitamin supplements in type 2 diabetes mellitus management: A review
    Mabel Kar-Wai Yan, Hanan Khalil
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S589.     CrossRef
  • Isotretinoin als „second hit“ bei Schizophrenie?
    Michael Kaczmarczyk, Carolin Laqua, Julian Hellmann-Regen, Isabella Heuser, Francesca Regen, Eric Hahn
    NeuroTransmitter.2017; 28(1): 29.     CrossRef
  • Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial
    J Libien, MJ Kupersmith, W Blaner, MP McDermott, S Gao, Y Liu, J Corbett, M Wall
    Journal of the Neurological Sciences.2017; 372: 78.     CrossRef
  • Synthesis of a new insulin-mimetic anti-diabetic drug containing vitamin A and vanadium(IV) salt: Chemico-biological characterizations
    Abdel Majid A Adam, Ahmed M Naglah, Mohamed A Al-Omar, Moamen S Refat
    International Journal of Immunopathology and Pharmacology.2017; 30(3): 272.     CrossRef
  • The LC–MS-based metabolomics of hydroxytyrosol administration in rats reveals amelioration of the metabolic syndrome
    Nikolaos Lemonakis, Hemant Poudyal, Maria Halabalaki, Lindsay Brown, Anthony Tsarbopoulos, Alexios-Leandros Skaltsounis, Evagelos Gikas
    Journal of Chromatography B.2017; 1041-1042: 45.     CrossRef
  • High serum carotenoids are associated with lower risk for developing elevated serum alanine aminotransferase among Japanese subjects: the Mikkabi cohort study
    Minoru Sugiura, Mieko Nakamura, Kazunori Ogawa, Yoshinori Ikoma, Masamichi Yano
    British Journal of Nutrition.2016; 115(8): 1462.     CrossRef
  • Retinoids have therapeutic action in type 2 diabetes
    Dilnasheen Meerza, Sarah Iqbal, Sufian Zaheer, Imrana Naseem
    Nutrition.2016; 32(7-8): 898.     CrossRef
  • Altered retinol status and expression of retinol-related proteins in streptozotocin-induced type 1 diabetic model rats
    Kimitaka Takitani, Keisuke Inoue, Maki Koh, Hiroshi Miyazaki, Akiko Inoue, Kanta Kishi, Hiroshi Tamai
    Journal of Clinical Biochemistry and Nutrition.2015; 56(3): 195.     CrossRef
  • Role of vitamin A in type 2 diabetes mellitus biology: Effects of intervention therapy in a deficient state
    Sarah Iqbal, Imrana Naseem
    Nutrition.2015; 31(7-8): 901.     CrossRef
  • Prepartum vitamin A supplementation enhances goat doe health status and kid viability and performance
    Mabrouk A. Abd Eldaim, Khalid M. Gaafar, Ragab A. Darwish, Hamad D. Mahboub, Mohamed A. Helal
    Small Ruminant Research.2015; 129: 6.     CrossRef
  • Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion
    William T. Moore, Suzanne M. Bowser, Dane W. Fausnacht, Linda L. Staley, Kyung-Shin Suh, Dongmin Liu
    Current Diabetes Reports.2015;[Epub]     CrossRef
  • High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study
    Minoru Sugiura, Mieko Nakamura, Kazunori Ogawa, Yoshinori Ikoma, Masamichi Yano
    BMJ Open Diabetes Research & Care.2015; 3(1): e000147.     CrossRef
  • Gestational diabetes: a risk of puerperal hypovitaminosis A?
    FERNANDA B.S. RESENDE, LARISSA Q. DE LIRA, EVELLYN C. GRILO, MAYARA S.R. LIMA, ROBERTO DIMENSTEIN
    Anais da Academia Brasileira de Ciências.2015; 87(1): 463.     CrossRef
  • Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components
    Marcia Teske, Ana Paula B. Melges, Fabiola Isabel S. de Souza, Fernando Luiz A. Fonseca, Roseli Oselka S. Sarni
    Revista Paulista de Pediatria.2014; 32(1): 50.     CrossRef
  • Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism
    Bing M. Liao, Katy Raddatz, Ling Zhong, Benjamin L. Parker, Mark J. Raftery, Carsten Schmitz-Peiffer
    PROTEOMICS.2014; 14(21-22): 2578.     CrossRef
  • Effect of all-trans-retinoic acid on the structure of thyroid gland and pituitary tyrotrophs in streptozotocin-diabetic male rats
    Ola A. Hussein, Amel M.M. Abdel-Hafez
    The Egyptian Journal of Histology.2013; 36(3): 691.     CrossRef
  • Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet (HFD) Diabetic Mice
    Yurong Guo, Manjula Darshi, Yuliang Ma, Guy A. Perkins, Zhouxin Shen, Kristofer J. Haushalter, Rintaro Saito, Ai Chen, Yun Sok Lee, Hemal H. Patel, Steven P. Briggs, Mark H. Ellisman, Jerrold M. Olefsky, Susan S. Taylor
    Molecular & Cellular Proteomics.2013; 12(12): 3744.     CrossRef
  • Deriving at candidate genes of metabolic stress from pancreas of WNIN/GR-Ob mutant rats
    Himadri Singh, Nappanveettil Giridharan, Ramesh Bhonde, Vijayalakshmi Venkatesan
    Islets.2013; 5(4): 133.     CrossRef
Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
Christos S. Mantzoros
Diabetes Metab J. 2012;36(3):181-189.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.181
  • 2,815 View
  • 28 Download
  • 18 Crossref
AbstractAbstract PDFPubReader   

Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, have low leptin levels. In the context of open-label, uncontrolled studies leptin administration, in physiological replacement doses, has been shown to have metabolically salutary effects in the rare patients with the syndrome of congenital lipodystrophy accompanied by leptin deficiency. Much more patients with lipodystrophy suffer from lipodystrophy and the metabolic syndrome associated with the use of highly active antiretroviral therapy. In this so called highly active antiretroviral therapy (HAART)-associated lipodystrophy and metabolic syndrome, patients demonstrate fat maldistribution with dyslipidemia, insulin resistance, and other metabolic complications. Leptin administration has been shown to decrease central fat mass and to improve fasting insulin/glucose levels and insulin sensitivity in human immunodeficiency virus-infected hypoleptinemic patients with HAART induced lipodystrophy and the metabolic syndrome. By contrast, the results of leptin treatment in leptin replete or hyperleptinemic obese individuals with glucose intolerance and diabetes mellitus have been minimal or null, presumably due to leptin tolerance or resistance that impairs leptin action. In this review, we present the emerging clinical applications and potential therapeutic uses of leptin in humans with lipodystrophy and the metabolic syndrome.

Citations

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  • Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery
    Michail Kokkorakis, Angeliki Katsarou, Niki Katsiki, Christos S. Mantzoros
    Metabolism.2023; 148: 155689.     CrossRef
  • The common pathophysiologic threads between Asian Indian diabetic’s ‘Thin Fat Phenotype’ and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences
    Aditya Saxena, Pradeep Tiwari, Nitin Wahi, Anshul Kumar, Sandeep Kumar Mathur
    Adipocyte.2020; 9(1): 253.     CrossRef
  • The effect of underweight on female and male reproduction
    Chrysoula Boutari, Panagiotis D. Pappas, Gesthimani Mintziori, Meletios P. Nigdelis, Loukas Athanasiadis, Dimitrios G. Goulis, Christos S. Mantzoros
    Metabolism.2020; 107: 154229.     CrossRef
  • Clinical presentations, metabolic abnormalities and end-organ complications in patients with familial partial lipodystrophy
    Baris Akinci, Huseyin Onay, Tevfik Demir, Şenay Savas-Erdeve, Ramazan Gen, Ilgin Yildirim Simsir, Fatma Ela Keskin, Mehmet Sercan Erturk, Ayse Kubat Uzum, Guzin Fidan Yaylali, Nilufer Kutbay Ozdemir, Tahir Atik, Samim Ozen, Banu Sarer Yurekli, Tugce Apayd
    Metabolism.2017; 72: 109.     CrossRef
  • CURRENT STATE OF THE PROBLEM OF OVERWEIGHT AND OBESITY IN WOMEN
    L. V. Tkachenko, N. I. Sviridova, T. V. Skladanovskaya
    Journal of Volgograd State Medical University.2017; 14(4): 3.     CrossRef
  • Leptin and Hormones
    Georgios A. Triantafyllou, Stavroula A. Paschou, Christos S. Mantzoros
    Endocrinology and Metabolism Clinics of North America.2016; 45(3): 633.     CrossRef
  • An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lepob/Lepob mouse
    Vinay Bhaskar, Ira D. Goldfine, Resi Gerstner, Kristen Michelson, Catarina Tran, Genevieve Nonet, David Bohmann, Elizabeth Pongo, Jingsong Zhao, Arnold H. Horwitz, Toshihiko Takeuchi, Mark White, John A. Corbin
    Obesity.2016; 24(8): 1687.     CrossRef
  • Lipodystrophic Diabetes Mellitus: a Lesson for Other Forms of Diabetes?
    Romina Ficarella, Luigi Laviola, Francesco Giorgino
    Current Diabetes Reports.2015;[Epub]     CrossRef
  • Aldehyde Dehydrogenase 1A1: Friend or Foe to Female Metabolism?
    Jennifer Petrosino, David DiSilvestro, Ouliana Ziouzenkova
    Nutrients.2014; 6(3): 950.     CrossRef
  • Comparative endocrinology of leptin: Assessing function in a phylogenetic context
    Richard L. Londraville, Yazmin Macotela, Robert J. Duff, Marietta R. Easterling, Qin Liu, Erica J. Crespi
    General and Comparative Endocrinology.2014; 203: 146.     CrossRef
  • Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge
    J.A. Paniagua, J.M. Escandell-Morales, D. Gil-Contreras, F.J. Berral de la Rosa, M. Romero-Jimenez, A. Gómez-Urbano, A. Sanchez-Lopez, E. Bellido, A. Poyato, B. Calatayud, A.J. Vidal-Puig
    Nutrition.2014; 30(2): 177.     CrossRef
  • The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review
    Konstantinos Michalakis, Gesthimani Mintziori, Athina Kaprara, Basil C. Tarlatzis, Dimitrios G. Goulis
    Metabolism.2013; 62(4): 457.     CrossRef
  • Dietary supplementation with long-chain monounsaturated fatty acids attenuates obesity-related metabolic dysfunction and increases expression of PPAR gamma in adipose tissue in type 2 diabetic KK-Ay mice
    Zhi-Hong Yang, Hiroko Miyahara, Yusuke Iwasaki, Jiro Takeo, Masashi Katayama
    Nutrition & Metabolism.2013; 10(1): 16.     CrossRef
  • Embryo-transfer of the F2 postnatal calorie restricted female rat offspring into a control intra-uterine environment normalizes the metabolic phenotype
    Meena Garg, Manikkavasagar Thamotharan, Yun Dai, Paul W.N. Lee, Sherin U. Devaskar
    Metabolism.2013; 62(3): 432.     CrossRef
  • Obesity in the ageing man
    K. Michalakis, D.G. Goulis, A. Vazaiou, G. Mintziori, A. Polymeris, A. Abrahamian-Michalakis
    Metabolism.2013; 62(10): 1341.     CrossRef
  • Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index
    Yusuf Ozkan, Esra Suay Timurkan, Suleyman Aydin, İbrahim Sahin, Mustafa Timurkan, Cihan Citil, Mehmet Kalayci, Musa Yilmaz, Aziz Aksoy, Zekiye Catak
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome
    Maria Dalamaga, Konstantinos Karmaniolas, John Chamberland, Athina Nikolaidou, Antigoni Lekka, Amalia Dionyssiou-Asteriou, Christos S. Mantzoros
    Metabolism.2013; 62(12): 1830.     CrossRef
  • Metabolische Korrektur mit Leptin
    Konstanze Miehle, Michael Stumvoll, Mathias Fasshauer, Wieland Kiess, Thomas Kapellen
    Info Diabetologie.2012; 6(5): 37.     CrossRef
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Seok Man Son
Diabetes Metab J. 2012;36(3):190-198.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.190
  • 5,097 View
  • 53 Download
  • 82 Crossref
AbstractAbstract PDFPubReader   

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

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  • Relationship of phytochemicals and antioxidant activities in Gymnema inodorum leaf extracts
    Onanong Nuchuchua, Wanwisa Srinuanchai, Chaisak Chansriniyom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Nitra Nuengchamnong, Uracha Ruktanonchai
    Heliyon.2024; 10(1): e23175.     CrossRef
  • The Role of Glutathione and Its Precursors in Type 2 Diabetes
    Dawn Tuell, George Ford, Evan Los, William Stone
    Antioxidants.2024; 13(2): 184.     CrossRef
  • Combined toxicity of microplastics and copper on Goniopora columns
    Ya-Ting Chen, De-Sing Ding, Yee Cheng Lim, Cheng-Di Dong, Shu-Ling Hsieh
    Environmental Pollution.2024; 345: 123515.     CrossRef
  • Oxidative stress, endothelial dysfunction, and N-acetylcysteine in type-2 diabetes mellitus
    Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
    Antioxidants & Redox Signaling.2024;[Epub]     CrossRef
  • Acacia gum: Chemistry, properties & food applications
    Deepak Mudgil, Sheweta Mudgil
    Food and Humanity.2024; 2: 100264.     CrossRef
  • High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
    Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
    Life Sciences.2023; 312: 121208.     CrossRef
  • Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
    Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
    Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
    Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
    Aquaculture Research.2023; 2023: 1.     CrossRef
  • Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
    Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
    Cells.2023; 12(4): 583.     CrossRef
  • In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
    Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
    Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
  • Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
    Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
    Biochimie.2022; 195: 114.     CrossRef
  • Effects of Smoking on Diabetic Nephropathy
    Yasemin Gündoğdu, İnan Anaforoğlu
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
    Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
    Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
    Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
  • Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
    Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
    Aquatic Toxicology.2022; 250: 106259.     CrossRef
  • “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
    Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
  • Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
    Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
    Molecules.2022; 27(22): 8043.     CrossRef
  • p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
    Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
    Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
  • Elucidation of phytochemicals and antioxidants properties of Sasa quelpaertensis
    Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
    International Journal of Food Properties.2021; 24(1): 210.     CrossRef
  • Organelle dynamics of endothelial mitochondria in diabetic angiopathy
    Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
    European Journal of Pharmacology.2021; 895: 173865.     CrossRef
  • Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
    Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
    Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
    Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
  • NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
    Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
    Cells.2021; 10(2): 314.     CrossRef
  • Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
    Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
    Sweta Pal, G. Nageswar Rao, Arttatrana Pal
    Life Sciences.2021; 279: 119693.     CrossRef
  • The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
    Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
    Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
  • The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
    V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
    Cytology and Genetics.2021; 55(4): 331.     CrossRef
  • Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
    Hollie Speer, Andrew J. McKune
    Antioxidants.2021; 10(8): 1247.     CrossRef
  • Natural Antioxidants in New Age-Related Diseases
    Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
    Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
  • Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
    Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
    Obesity Medicine.2020; 19: 100274.     CrossRef
  • Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
    Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
    Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
  • Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
    Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
    Industrial Crops and Products.2020; 146: 112158.     CrossRef
  • Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
    Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Heme on Pulmonary Malaria: Friend or Foe?
    Tatiana Almeida Pádua, Mariana Conceição Souza
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
    Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
    Experimental Eye Research.2020; 201: 108255.     CrossRef
  • The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
    Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
    Nutrients.2020; 12(7): 2108.     CrossRef
  • Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
    Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
    Antioxidants.2020; 9(6): 491.     CrossRef
  • Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
    Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
  • Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
    M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
    Surfaces and Interfaces.2020; 19: 100540.     CrossRef
  • The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
    Sheetal Panday, Raghav Talreja, Mahendra Kavdia
    Microvascular Research.2020; 131: 104010.     CrossRef
  • Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
    V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
    Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
  • Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
    Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
    Frontiers in Veterinary Science.2020;[Epub]     CrossRef
  • Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
    Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
  • Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
    J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
    Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
  • Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
    Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • The impact of xanthine oxidase (XO) on hemolytic diseases
    Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
    Redox Biology.2019; 21: 101072.     CrossRef
  • What is responsible for antioxidant properties of polyphenolic compounds from plants?
    Małgorzata Olszowy
    Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
  • Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
    Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
    Cells.2019; 8(5): 464.     CrossRef
  • Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
    Xiaojuan Yang, Jing Song, Liang-Jun Yan
    Antioxidants.2019; 8(2): 32.     CrossRef
  • Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
    Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
    Current Eye Research.2019; 44(3): 294.     CrossRef
  • Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
    Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
    Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
    Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
    Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
  • Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
    Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
    Reproductive Sciences.2018; 25(11): 1531.     CrossRef
  • Nutrients and Oxidative Stress: Friend or Foe?
    Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
    Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • An Update on Hypertension in Children With Type 1 Diabetes
    Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
    Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
  • Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
    Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
    Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
    Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
  • Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
    Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
    Food Research International.2017; 95: 117.     CrossRef
  • Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
    Veerappan Ramanathan, Malarvili Thekkumala
    Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
  • Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
    Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
    Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
  • Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
    Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
    BioImpacts.2017; 7(4): 219.     CrossRef
  • The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
    Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
    The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
  • Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
    Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
    Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
    Aging and disease.2016; 7(1): 90.     CrossRef
  • İNSAN VE HAYVANLARDA DİABETES MELLİTUS
    Özlem ÖZMEN, Senay TOPSAKAL
    Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
  • The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
    Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
    Pharmacological Research.2016; 113: 186.     CrossRef
  • Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
    Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
    Food Chemistry.2016; 201: 315.     CrossRef
  • Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
    Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
    Endocrine.2015; 50(2): 405.     CrossRef
  • Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
    Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
    International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
  • Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
    L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
    British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
  • Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
    Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
    Pathophysiology.2015; 22(4): 189.     CrossRef
  • Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
    J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
    Oral Diseases.2015; 21(5): 634.     CrossRef
  • Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
    Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
    PLOS ONE.2015; 10(4): e0123987.     CrossRef
  • Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
    Abeer Hanafy, Jihan M. Badr
    Natural Product Research.2014; 28(24): 2351.     CrossRef
  • Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
    TM Boĭchuk, TP Savchuk
    Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
  • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    Paulo Zoé Costa, Raquel Soares
    Life Sciences.2013; 92(22): 1037.     CrossRef
  • Oxidative-stress-induced epigenetic changes in chronic diabetic complications
    Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
    Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
  • Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
    Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
    Archives of Medical Research.2013; 44(7): 514.     CrossRef
  • Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
    Daye Cheng, Bin Liang, Yunhui Li
    BioMed Research International.2013; 2013: 1.     CrossRef
Sulwon Lecture 2011
Post-Renal Transplant Diabetes Mellitus in Korean Subjects: Superimposition of Transplant-Related Immunosuppressant Factors on Genetic and Type 2 Diabetic Risk Factors
Hyun Chul Lee
Diabetes Metab J. 2012;36(3):199-206.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.199
  • 3,553 View
  • 31 Download
  • 9 Crossref
AbstractAbstract PDFPubReader   

Postrenal transplantation diabetes mellitus (PTDM), or new-onset diabetes after organ transplantation, is an important chronic transplant-associated complication. Similar to type 2 diabetes, decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind the development of PTDM. However, β-cell dysfunction rather than insulin resistance seems to be a greater contributing factor in the development of PTDM. Increased age, family history of diabetes, ethnicity, genetic variation, obesity, and hepatitis C are partially accountable for an increased underlying risk of PTDM in renal allograft recipients. In addition, the use of and kinds of immunosuppressive agents are key transplant-associated risk factors. Recently, a number of genetic variants or polymorphisms susceptible to immunosuppressants have been reported to be associated with calcineurin inhibition-induced β-cell dysfunction. The identification of high risk factors of PTDM would help prevent PTDM and improve long-term patient outcomes by allowing for personalized immunosuppressant regimens and by managing cardiovascular risk factors.

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  • Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience
    Guillermo E. Guzmán, Angela M. Victoria, Isabella Ramos, Alejandro Maldonado, Eliana Manzi, Juan F. Contreras-Valero, Liliana Mesa, Johanna Schweineberg, Juan G. Posada, Jorge I. Villegas, Luis A. Caicedo, Carlos E. Durán
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Synthesis of Fructose Biosensors and Progressing Their Efficiency Using Californium Colloidal Nanoparticles for Detecting Fructose and Triglycerides
    Alireza Heidari
    Advanced Science, Engineering and Medicine.2020; 12(8): 1002.     CrossRef
  • Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
    Hisao Shimada, Junji Uchida, Shunji Nishide, Kazuya Kabei, Akihiro Kosoku, Keiko Maeda, Tomoaki Iwai, Toshihide Naganuma, Yoshiaki Takemoto, Tatsuya Nakatani
    Journal of Clinical Medicine.2019; 8(7): 920.     CrossRef
  • Diabètes post-transplantation rénale
    Danièle Dubois-Laforgue
    Néphrologie & Thérapeutique.2017; 13: S137.     CrossRef
  • Risk assessment and management of post-transplant diabetes mellitus
    Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Metabolism.2016; 65(10): 1559.     CrossRef
  • Renal posttransplantation diabetes mellitus: An overview
    Ana Laura Pimentel, Andrea Carla Bauer, Joíza Lins Camargo
    Clinica Chimica Acta.2015; 450: 327.     CrossRef
  • HMG CoA Reductase Inhibitor Treatment Induces Dysglycemia in Renal Allograft Recipients
    Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Yongin Cho, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang
    Transplantation.2014; 97(4): 419.     CrossRef
  • Statin therapy is associated with the development of new-onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels
    Yongin Cho, Min Jung Lee, Eun Yeong Choe, Chang Hee Jung, Dong Jin Joo, Myoung Soo Kim, Bong Soo Cha, Joong-Yeol Park, Eun Seok Kang
    Liver Transplantation.2014; 20(5): 557.     CrossRef
  • Post-Transplant Diabetes Mellitus: Is It Associated With Poor Allograft Outcomes in Renal Transplants?
    J.Y. Choi, O.J. Kwon
    Transplantation Proceedings.2013; 45(8): 2892.     CrossRef
Editorial
The Role of Cortisol in the Pathogenesis of the Metabolic Syndrome
In-Kyung Jeong
Diabetes Metab J. 2012;36(3):207-210.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.207
  • 3,269 View
  • 31 Download
  • 11 Crossref
PDFPubReader   

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  • Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection
    Simran Kaur, Niharika Gupta, Bansi D. Malhotra
    Expert Review of Molecular Diagnostics.2023; 23(3): 217.     CrossRef
  • Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients
    Thomas P. Dooley, Johnny Martín Paredes Pérez, Carlos Rengifo Rodriquez
    Clinical Phytoscience.2022;[Epub]     CrossRef
  • GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome
    León F. Villegas Vílchez, Julio Hidalgo Ascencios, Thomas P. Dooley
    BMC Complementary Medicine and Therapies.2022;[Epub]     CrossRef
  • Evaluation of Stress and Associated Biochemical Changes in Patients with Type 2 Diabetes Mellitus and Obesity
    Kanchan Tyagi, Nidhi Bharal Agarwal, Prem Kapur, Sunil Kohli, Rajinder K Jalali
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 705.     CrossRef
  • Association between hair cortisol concentration and metabolic syndrome
    Eglė Mazgelytė, Asta Mažeikienė, Neringa Burokienė, Rėda Matuzevičienė, Aušra Linkevičiūtė, Zita Aušrelė Kučinskienė, Dovilė Karčiauskaitė
    Open Medicine.2021; 16(1): 873.     CrossRef
  • Modeling the Influence of Chronic Sleep Restriction on Cortisol Circadian Rhythms, with Implications for Metabolic Disorders
    Rohit Rao, Pramod Somvanshi, Elizabeth B. Klerman, Charles Marmar, Francis J. Doyle
    Metabolites.2021; 11(8): 483.     CrossRef
  • A metabolic handbook for the COVID-19 pandemic
    Janelle S. Ayres
    Nature Metabolism.2020; 2(7): 572.     CrossRef
  • Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets
    Nerea Gandoy-Fieiras, Jose Ramon Gonzalez-Juanatey, Sonia Eiras
    International Journal of Molecular Sciences.2020; 21(7): 2641.     CrossRef
  • Treatments of nonalcoholic fatty liver disease in adults who have no other illness: A Review article
    Sepideh Ahadi, Afshin Gharekhani, Afshin Shiva
    Arab Journal of Gastroenterology.2019; 20(4): 189.     CrossRef
  • HSD11B1 gene polymorphisms in type 2 diabetes and metabolic syndrome—Do we have evidence for the association?
    Nayana Devang, Nandini M, Satish Rao, Prabha Adhikari
    International Journal of Diabetes in Developing Countries.2016; 36(1): 95.     CrossRef
  • Type 2 diabetes mellitus and depression
    Andrey. Ya. Kravchenko, V. V. Sahnenko, A. V. Budnevskyj, S. N. Podvygyn
    Clinical Medicine (Russian Journal).2016; 94(2): 97.     CrossRef
Original Articles
Effects of Aerobic Exercise Intensity on Abdominal and Thigh Adipose Tissue and Skeletal Muscle Attenuation in Overweight Women with Type 2 Diabetes Mellitus
Ji Yeon Jung, Kyung Ah Han, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
Diabetes Metab J. 2012;36(3):211-221.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.211
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AbstractAbstract PDFPubReader   
Background

We investigated the effects of exercise intensity on abdominal and mid-thigh adipose tissue, attenuation of skeletal muscle, and insulin sensitivity in overweight women with type 2 diabetes mellitus (T2DM).

Methods

Twenty-eight patients were randomly assigned to control (CG, n=12), moderate intensity exercise (MEG, n=8), or vigorous intensity exercise (VEG, n=8) group. Subjects in both exercise groups completed a 12-week exercise program (MEG, 3.6 to 5.2 METs; VEG, ≥5.2 METs) that was monitored by accelerometers. We assessed body mass index (BMI), total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), mid-thigh intramuscular adipose tissue (TIMAT), total skeletal muscle (TTM), low density skeletal muscle (TLDM), and normal density skeletal muscle (TNDM) using computed tomography, and measured insulin sensitivity with an insulin tolerance test (KITT), before and after the intervention.

Results

At baseline, the mean age was 53.8±7.9 years, duration of diabetes was 3.8±2.3 years, and BMI was 26.6±2.6 kg/m2. After 12 weeks, the percent change (%C) in BMI, TIMAT, and TLDM were not different among three groups. However, %C in TFA and VFA were significantly reduced in MEG compared to CG (P=0.026 and P=0.008, respectively). %C SFA was significantly reduced in VEG compared to CG (P=0.038) and %C TTM, TNDM, and KITT were significantly increased in VEG compared to the CG (P=0.044, P=0.007, and P=0.016, respectively).

Conclusion

Although there was no difference in the change in BMI among groups, TFA and VFA were more reduced in MEG, and only VEG increased TTM, TNDM, and insulin sensitivity compared to CG.

Citations

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  • Intermuscular adipose tissue in metabolic disease
    Bret H. Goodpaster, Bryan C. Bergman, Andrea M. Brennan, Lauren M. Sparks
    Nature Reviews Endocrinology.2023; 19(5): 285.     CrossRef
  • Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials
    Francesco Recchia, Chit K. Leung, Angus P. Yu, Welton Leung, Danny J. Yu, Daniel Y. Fong, David Montero, Chi-Ho Lee, Stephen H.S. Wong, Parco M. Siu
    British Journal of Sports Medicine.2023; 57(16): 1035.     CrossRef
  • Muscle quality: the assessment, prognosis, and intervention
    翔 畑中, 洋祐 大須賀
    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2023; 60(2): 103.     CrossRef
  • Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function
    Kristine M. Erlandson, Triin Umbleja, Michael T. Lu, Jana Taron, Heather J. Ribaudo, Edgar T. Overton, Rachel M. Presti, David W. Haas, Paul E. Sax, Michael T. Yin, Bingxue Kris Zhai, Rochelle Louis, Namrata Upadhyay, Parastou Eslami, Pamela S. Douglas, M
    JAIDS Journal of Acquired Immune Deficiency Syndromes.2023; 94(2): 174.     CrossRef
  • Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
    Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
    Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
    Obesity Reviews.2022;[Epub]     CrossRef
  • Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis
    Robinson Ramírez-Vélez, Yasmin Ezzatvar, Mikel Izquierdo, Antonio García-Hermoso
    Journal of Applied Physiology.2021; 130(1): 245.     CrossRef
  • Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
    Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
    International Journal of Obesity.2021; 45(5): 982.     CrossRef
  • Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis
    Mauro Tuñón-Suárez, Alvaro Reyes-Ponce, Rodrigo Godoy-Órdenes, Nicolás Quezada, Marcelo Flores-Opazo
    Physical Therapy.2021;[Epub]     CrossRef
  • Low-attenuation muscle is a predictor of diabetes mellitus: A population-based cohort study
    Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
    Nutrition.2020; 74: 110752.     CrossRef
  • Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis
    Guillem Jabardo-Camprubí, Rafel Donat-Roca, Mercè Sitjà-Rabert, Raimon Milà-Villarroel, Judit Bort-Roig
    Physiology & Behavior.2020; 215: 112786.     CrossRef
  • High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Middle-Aged and Older Patients with Type 2 Diabetes: A Randomized Controlled Crossover Trial of the Acute Effects of Treadmill Walking on Glycemic Control
    Romeu Mendes, Nelson Sousa, José Luís Themudo-Barata, Victor Machado Reis
    International Journal of Environmental Research and Public Health.2019; 16(21): 4163.     CrossRef
  • Trunk muscle quality assessed by computed tomography: Association with adiposity indices and glucose tolerance in men
    Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
    Metabolism.2018; 85: 205.     CrossRef
  • Counting Footsteps with a Pedometer to Improve HMW Adiponectin and Metabolic Syndrome among Young Female Adults in the United Arab Emirates
    Hayder Hasan, Amita Attlee, Hamid Jan Bin Jan Mohamed, Norliyana Aris, Wan Abdul Manan Bin Wan Muda
    Journal of Obesity.2018; 2018: 1.     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
    Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
    Acta Diabetologica.2016; 53(5): 769.     CrossRef
  • A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
    R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
    Obesity Reviews.2016; 17(8): 664.     CrossRef
  • Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
    Thomas Brioche, Allan F. Pagano, Guillaume Py, Angèle Chopard
    Molecular Aspects of Medicine.2016; 50: 56.     CrossRef
  • Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes
    Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han
    Diabetes & Metabolism Journal.2014; 38(6): 439.     CrossRef
  • Intermuscular Fat: A Review of the Consequences and Causes
    Odessa Addison, Robin L. Marcus, Paul C. LaStayo, Alice S. Ryan
    International Journal of Endocrinology.2014; 2014: 1.     CrossRef
  • Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome
    Byung Sam Park, Ji Sung Yoon
    Diabetes & Metabolism Journal.2013; 37(6): 458.     CrossRef
Influence of the Duration of Diabetes on the Outcome of a Diabetes Self-Management Education Program
Seung-Hyun Ko, Sin-Ae Park, Jae-Hyoung Cho, Sun-Hye Ko, Kyung-Mi Shin, Seung-Hwan Lee, Ki-Ho Song, Yong-Moon Park, Yu-Bae Ahn
Diabetes Metab J. 2012;36(3):222-229.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.222
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AbstractAbstract PDFPubReader   
Background

Diabetes education and lifestyle modification are critical components in controlling blood glucose levels of people with type 2 diabetes. Until now, available data on the effectiveness of education with respect to the duration of diabetes are limited. We investigated whether adherence to lifestyle behavior modification prompted by diabetes education was influenced by the duration of diabetes.

Methods

Two hundred and twenty-five people with type 2 diabetes were recruited for an intensive, collaborative, group-based diabetes education program with annual reinforcement. We divided the patients into two groups based on the duration of their diabetes prior to the education program (≤1 year [≤1Y] vs. ≥3 years [≥3Y]). Dietary habits, physical activity, and the frequency of blood glucose self-monitoring were evaluated with a questionnaire prior to education and at the follow-up endpoint.

Results

The mean follow-up period was 32.2 months. The mean hemoglobin A1c (A1C) value was significantly lower in the ≤1Y group. Self-care behaviors, measured by scores for dietary habits (P=0.004) and physical activity (P<0.001), were higher at the endpoint in the ≤1Y group than in the ≥3Y group. Logistic regression analysis revealed that a longer diabetes duration before education was significantly associated with mean A1C levels greater than or equal to 7.0% (53 mmol/mol).

Conclusion

Diabetes duration influenced the effectiveness of diabetes education on lifestyle behavior modification and glycemic control. More-intense, regular, and sustained reinforcement with encouragement may be required for individuals with longstanding type 2 diabetes.

Citations

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  • Prevalence of type 2 diabetes complications and its association with diet knowledge and skills and self‐care barriers in Tabriz, Iran: A cross‐sectional study
    Habib Jalilian, Elnaz Javanshir, Leila Torkzadeh, Saeedeh Fehresti, Nazanin Mir, Majid Heidari‐Jamebozorgi, Somayeh Heydari
    Health Science Reports.2023;[Epub]     CrossRef
  • Continuing the quality improvement of an electronic personal health record and interactive website for people with diabetes in Scotland (My Diabetes My Way)
    Cathy Shields, Nicholas T. Conway, Brian Allardice, Deborah J. Wake, Scott G. Cunningham
    Diabetic Medicine.2023;[Epub]     CrossRef
  • The use of nomogram for detecting mild cognitive impairment in patients with type 2 diabetes mellitus
    Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Yu Xie, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Wenjie Dai
    Journal of Diabetes.2023; 15(5): 448.     CrossRef
  • DENTAL IMPLANT TREATMENT IN DIABETES MELLITUS (DM) PATIENTS: REVIEW
    Hakob Khachatryan
    BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2023; : 121.     CrossRef
  • An association between socioeconomic status and preventive screening for diabetic eye and kidney complications among individuals with type 2 diabetes
    Changwoo Shon, Jongnam Hwang
    Korean Journal of Health Education and Promotion.2023; 40(5): 27.     CrossRef
  • Association of quality of life with medication adherence and glycemic control in patients with type 1 diabetes
    Farimah Fayyaz, Parham Mardi, Sahar Sobhani, Leily Sokoty, Fatemeh Aghamahdi, Mostafa Qorbani
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • Effect of aerobic training on baroreflex sensitivity, heart rate recovery, and heart rate variability in type 2 diabetes: a systematic review
    Sarah Parveen, Muhammad Azharuddin, Majumi M. Noohu
    International Journal of Diabetes in Developing Countries.2023;[Epub]     CrossRef
  • Managing type 2 diabetes and depression with Mindfulness-integrated Cognitive Behavior Therapy (MiCBT)
    Fateh Sohrabi, Ahmad Sohrabi, Narges Shams-Alizadeh, Bruno A. Cayoun
    Discover Psychology.2022;[Epub]     CrossRef
  • Perception of benefits and barriers associated with dementia prevention behaviors among people with diabetes
    Noppamas Pipatpiboon, Nut Koonrungsesomboon, Wachira Suriyawong, Jirapas Sripetchwandee, Sue Turale
    Nursing & Health Sciences.2022; 24(1): 274.     CrossRef
  • An exploratory study on the knowledge, attitude and practice of sharp disposal among type 2 diabetes mellitus patients in Northern Peninsular Malaysia
    Jin Yi Choo, Yen Ping Ng, Ahmad Kamal Ariffin Abdul Jamil, Wei Kai Heng, Yee Mei Ng, Jing Ng, Cheng Hoon Yap
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(4): 102479.     CrossRef
  • Efficacy of Personalized Diabetes Self-care Using an Electronic Medical Record–Integrated Mobile App in Patients With Type 2 Diabetes: 6-Month Randomized Controlled Trial
    Eun Young Lee, Seon-Ah Cha, Jae-Seung Yun, Sun-Young Lim, Jin-Hee Lee, Yu-Bae Ahn, Kun-Ho Yoon, Min Kyung Hyun, Seung-Hyun Ko
    Journal of Medical Internet Research.2022; 24(7): e37430.     CrossRef
  • Real-world Benefits of Diabetes Management App Use and Self-monitoring of Blood Glucose on Glycemic Control: Retrospective Analyses
    Ya-Ting Chang, Yu-Zhen Tu, Hung-Yi Chiou, Ken Lai, Neng Chun Yu
    JMIR mHealth and uHealth.2022; 10(6): e31764.     CrossRef
  • Glycemic control and its influencing factors in type 2 diabetes patients in Anhui, China
    Xiu-Ya Xing, Xin-Yi Wang, Xi Fang, Jing-Qiao Xu, Ye-Ji Chen, Wei Xu, Hua-Dong Wang, Zhi-Rong Liu, Sha-Sha Tao
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Time for Using Machine Learning for Dose Guidance in Titration of People With Type 2 Diabetes? A Systematic Review of Basal Insulin Dose Guidance
    Camilla Heisel Nyholm Thomsen, Stine Hangaard, Thomas Kronborg, Peter Vestergaard, Ole Hejlesen, Morten Hasselstrøm Jensen
    Journal of Diabetes Science and Technology.2022; : 193229682211459.     CrossRef
  • Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes
    Marko Grahovac, Marko Kumric, Marino Vilovic, Dinko Martinovic, Ante Kreso, Tina Ticinovic Kurir, Josip Vrdoljak, Karlo Prizmic, Joško Božić
    World Journal of Diabetes.2021; 12(11): 1942.     CrossRef
  • Impact of Diabetes and Disease Duration on Work Status Among U.S. Older Adults
    Miriam Mutambudzi, Cesar Gonzalez Gonzalez, Rebecca Wong
    Journal of Aging and Health.2020; 32(5-6): 432.     CrossRef
  • The association of illness perceptions and God locus of health control with self-care behaviours in patients with type 2 diabetes in Saudi Arabia
    Mohsen Alyami, Anna Serlachius, Ibrahim Mokhtar, Elizabeth Broadbent
    Health Psychology and Behavioral Medicine.2020; 8(1): 329.     CrossRef
  • The Impact of a Community-Based Food Education Program on Nutrition-Related Knowledge in Middle-Aged and Older Patients with Type 2 Diabetes: Results of a Pilot Randomized Controlled Trial
    Carlos Vasconcelos, António Almeida, Maria Cabral, Elisabete Ramos, Romeu Mendes
    International Journal of Environmental Research and Public Health.2019; 16(13): 2403.     CrossRef
  • Diabetes-Related Health Care Utilization and Dietary Intake Among Food Pantry Clients
    Eric M. Bomberg, Sophie Rosenmoss, Morgan Smith, Elaine Waxman, Hilary K. Seligman
    Health Equity.2019; 3(1): 644.     CrossRef
  • Factors Contributing to Sharp Waste Disposal at Health Care Facility Among Diabetic Patients in North-East Peninsular Malaysia
    Ummu Atiyyah Hasan, Suhaily Mohd Hairon, Najib Majdi Yaacob, Aziah Daud, Anees Abdul Hamid, Norzaihan Hassan, Mohd Faiz Ariffin, Lau Yi Vun
    International Journal of Environmental Research and Public Health.2019; 16(13): 2251.     CrossRef
  • Effectiveness of Diabetes Community Sharp Disposal Education Module in Primary Care: An Experimental Study in North-East Peninsular Malaysia
    Ummu Atiyyah Hasan, Suhaily Mohd Hairon, Najib Majdi Yaacob, Aziah Daud, Anees Abdul Hamid, Norzaihan Hassan, Mohd Faiz Ariffin, Lau Yi Vun
    International Journal of Environmental Research and Public Health.2019; 16(18): 3356.     CrossRef
  • Analysis of the Relationship between the Referral and Evolution of Patients with Type 2 Diabetes Mellitus
    Camilo Alvarez, Cecilia Saint-Pierre, Valeria Herskovic, Marcos Sepúlveda
    International Journal of Environmental Research and Public Health.2018; 15(7): 1534.     CrossRef
  • Clinical characteristics of Chinese patients with duration of type 2 diabetes >40 years
    Tingting Song, Yingying Luo, Xuhui Wang, Jing Li, Qian Han, Hong Zhu, Wei Zhao, Weidong Li, Zhong Sun, Xilin Yang
    Journal of Diabetes.2017; 9(1): 45.     CrossRef
  • Impacto de intervenções educativas na redução das complicações diabéticas: revisão sistemática
    Marcela Machado Menezes, Camila Takáo Lopes, Lilia de Souza Nogueira
    Revista Brasileira de Enfermagem.2016; 69(4): 773.     CrossRef
  • The Well-Being and Treatment Satisfaction of Diabetic Patients in an Outpatient Setting at a General Hospital in Korea
    Hwa-Sun Park, Sin Na Lee, Min Young Baek, Seung Hee Yu, Young Sil Eom, Sihoon Lee, Ki Young Lee, Yeun Sun Kim, Byung Joon Kim, Kwang Won Kim, Ie Byung Park
    The Journal of Korean Diabetes.2016; 17(2): 123.     CrossRef
  • Poor glycemic control in type 2 diabetes in the South of the Sahara: The issue of limited access to an HbA1c test
    Alioune Camara, Naby M. Baldé, Joelle Sobngwi-Tambekou, André P. Kengne, Mansour M. Diallo, Alain P.K. Tchatchoua, Amadou Kaké, Ngamani Sylvie, Beverley Balkau, Fabrice Bonnet, Eugène Sobngwi
    Diabetes Research and Clinical Practice.2015; 108(1): 187.     CrossRef
  • Effect of Group Training on Glycemic Control in Patients With Diabetes Type-I
    Marjan Naseri, Shahnaz Rostami, Bahman Dashtebozorgi
    Jundishapur Journal of Chronic Disease Care.2015;[Epub]     CrossRef
  • Clinical audit of patients using DPP4 inhibitors in longstanding type 2 diabetes
    K.V.S. Hari Kumar, A.K. Gupta
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2015; 9(4): 277.     CrossRef
  • Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women
    Hye-Ok Lee, Jung-Eun Yim, Young-Seol Kim, Ryowon Choue
    Nutrition Research and Practice.2014; 8(4): 469.     CrossRef
  • Inverse Association between Glycated Albumin and Insulin Secretory Function May Explain Higher Levels of Glycated Albumin in Subjects with Longer Duration of Diabetes
    Yong-ho Lee, Mi Hyang Kown, Kwang Joon Kim, Eun Young Lee, Daham Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Marià Alemany
    PLoS ONE.2014; 9(9): e108772.     CrossRef
  • Systematic review of the psychometric properties and theoretical grounding of instruments evaluating self‐care in people with type 2 Diabetes Mellitus
    Jorge Caro‐Bautista, Francisco Javier Martín‐Santos, Jose Miguel Morales‐Asencio
    Journal of Advanced Nursing.2014; 70(6): 1209.     CrossRef
  • It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
    Sang Yong Kim
    Diabetes & Metabolism Journal.2014; 38(3): 194.     CrossRef
  • Efficacy of the Smartphone-Based Glucose Management Application Stratified by User Satisfaction
    Hun-Sung Kim, Wona Choi, Eun Kyoung Baek, Yun A Kim, So Jung Yang, In Young Choi, Kun-Ho Yoon, Jae-Hyoung Cho
    Diabetes & Metabolism Journal.2014; 38(3): 204.     CrossRef
  • Education as Prescription for Patients with Type 2 Diabetes Mellitus: Compliance and Efficacy in Clinical Practice
    Mi Yeon Kim, Sunghwan Suh, Sang-Man Jin, Se Won Kim, Ji Cheol Bae, Kyu Yeon Hur, Sung Hye Kim, Mi Yong Rha, Young Yun Cho, Myung-Shik Lee, Moon Kyu Lee, Kwang-Won Kim, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2012; 36(6): 452.     CrossRef
Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus
Eun Yeong Choe, Yong-ho Lee, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee
Diabetes Metab J. 2012;36(3):230-236.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.230
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AbstractAbstract PDFPubReader   
Background

The present study investigates the efficacy in glycemic control by adding once-a-day glulisine to glargine as a basal plus regimen and factors influencing glycemic control with the basal plus regimen in Korean subjects with type 2 diabetes.

Methods

In the present retrospective study, subjects previously treated with the basal plus regimens for at least 6 months were reviewed. Changes in glycemic profiles and clinical parameters were evaluated.

Results

A total of 87 subjects were ultimately enrolled in this study. At baseline, mean glycated hemoglobin (A1c) and glycated albumin were 8.5% (8.0% to 9.6%) and 25.2±7.6%, respectively. After treatment with the basal plus regimen, patients had significant reductions of A1c at 6 months (0.8±0.1%, P<0.001) and their postprandial glucose levels were decreased by 48.7±10.3 mg/dL (P<0.001). Multiple logistic regression showed old age (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.02 to 1.55), high initial A1c (OR, 22.21; 95% CI, 2.44 to 201.78), and lower amounts of glargine (OR, 0.85; 95% CI, 0.76 to 0.99), and glimepiride (OR, 0.23; 95% CI, 0.06 to 0.93) at baseline were independently associated with good responders whose A1c reduction was more than 0.5%.

Conclusion

The authors suggest a basal plus regimen may be effective in reducing glucose levels of subjects with old age, high initial A1c, and patients on low doses of glimepiride and glargine. Despite the use of high doses of hypoglycemic agents, elderly patients with poorly-controlled diabetes are preferred for early initiation of the basal plus regimen.

Citations

Citations to this article as recorded by  
  • Titration of basal insulin or immediate addition of rapid acting insulin in patients not at target using basal insulin supported oral antidiabetic treatment – A prospective observational study in 2202 patients
    Thorsten Siegmund, Martin Pfohl, Thomas Forst, Stefan Pscherer, Peter Bramlage, Johannes Foersch, Anja Borck, Jochen Seufert
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11(1): 51.     CrossRef
  • Characteristics Predictive for a Successful Switch from Insulin Analogue Therapy to Oral Hypoglycemic Agents in Patients with Type 2 Diabetes
    Gyuri Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
    Yonsei Medical Journal.2016; 57(6): 1395.     CrossRef
  • Clinical Characteristics of Patients Responding to Once-Daily Basal Insulin Therapy in Korean Subjects with Type 2 Diabetes
    Sun Ok Song, You-Cheol Hwang, Kyu-Jeung Ahn, Bong Soo Cha, Young Duk Song, Dae Wook Lee, Byung-Wan Lee
    Diabetes Therapy.2015; 6(4): 547.     CrossRef
  • The optimal morning:evening ratio in total dose of twice‐daily biphasic insulin analogue in poorly controlled Type 2 diabetes: a 24‐week multi‐centre prospective, randomized controlled, open‐labelled clinical study
    C. H. Jung, J.‐Y. Park, J. H. Cho, K.‐H. Yoon, H. K. Yang, Y.‐H. Lee, B. S. Cha, B.‐W. Lee
    Diabetic Medicine.2014; 31(1): 68.     CrossRef
  • The glycemic efficacies of insulin analogue regimens according to baseline glycemic status in Korean patients with type 2 diabetes: sub‐analysis from the A 1 chieve ® study
    Y.‐C. Hwang, J. G. Kang, K. J. Ahn, B. S. Cha, S.‐H. Ihm, S. Lee, M. Kim, B.‐W. Lee
    International Journal of Clinical Practice.2014; 68(11): 1338.     CrossRef
Metabolic Syndrome versus Framingham Risk Score for Association of Self-Reported Coronary Heart Disease: The 2005 Korean Health and Nutrition Examination Survey
Hye Mi Kang, Dong-Jun Kim
Diabetes Metab J. 2012;36(3):237-244.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.237
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AbstractAbstract PDFPubReader   
Background

Several studies in Western populations have indicated that metabolic syndrome (MetS) is inferior to the Framingham risk score (FRS) in predicting coronary heart disease (CHD). However there has been no study about the predictability of MetS vs. FRS for CHD in Korea.

Methods

Among the 43,145 persons from the third Korea National Health and Nutrition Examination Survey in 2005, laboratory test and nutritional survey data from 5,271 persons were examined. Participants were also asked to recall a physician's diagnosis of CHD.

Results

The median age was 46 (range, 20 to 78) in men (n=2,257) and 44 (range, 20 to 78) years in women (n=3,014). Prevalence of self-reported CHD was 1.7% in men and 2.1% in women. Receiver operating characteristic curves and their respective area under the curve (AUC) were used to compare the ability of the FRS and the number of components of MetS to predict self-reported CHD in each sex. In men, AUC of FRS was significantly larger than that of MetS (0.767 [0.708 to 0.819] vs. 0.677 [0.541 to 0.713], P<0.01). In women, AUC of FRS was comparable to that of MetS (0.777 [0.728 to 0.826] vs. 0.733 [0.673 to 0.795]), and was not significant.

Conclusion

The data suggested that FRS was more closely associated with CHD compared to MetS in Korean men.

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    Scientific Reports.2018;[Epub]     CrossRef
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    IJC Metabolic & Endocrine.2014; 4: 63.     CrossRef
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    Gynecological Endocrinology.2013; 29(10): 921.     CrossRef
  • Hemoglobin A1c Is Positively Correlated with Framingham Risk Score in Older, Apparently Healthy Nondiabetic Korean Adults
    Ji Hye Shin, Ji In Kang, Yun Jung, Young Min Choi, Hyun Jung Park, Jung Hae So, Jin Hwa Kim, Sang Yong Kim, Hak Yeon Bae
    Endocrinology and Metabolism.2013; 28(2): 103.     CrossRef
  • Cardiovascular Disease Risk of Bus Drivers in a City of Korea
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    Annals of Occupational and Environmental Medicine.2013; 25(1): 34.     CrossRef
The Association between Midnight Salivary Cortisol and Metabolic Syndrome in Korean Adults
Yun-Mi Jang, Eun Jung Lee, Dong Lim Kim, Suk Kyeong Kim, Kee-Ho Song
Diabetes Metab J. 2012;36(3):245-250.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.245
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AbstractAbstract PDFPubReader   
Background

The common characteristics of metabolic syndrome (MetS) and Cushing's syndrome suggest that excess cortisol may be involved in the pathogenesis of MetS. Salivary cortisol measurements are simple and can be surrogates for plasma free cortisol, which is the most biologically active form. We evaluated the association between levels of midnight salivary cortisol and MetS in Korean adults.

Methods

A total of 46 subjects, aged 20 to 70 years, who visited the Health Care Center at Konkuk University Hospital from August 2008 to August 2009 were enrolled. We compared the levels of midnight salivary cortisol in subjects with MetS with those in subjects without MetS. We analyzed the associations between midnight salivary cortisol levels and components of MetS.

Results

Midnight salivary cortisol levels were higher in the MetS group (70±42.4 ng/dL, n=12) than that in the group without MetS (48.1±36.8 ng/dL, n=34) (P=0.001). Positive correlations were observed between midnight salivary cortisol levels and waist circumference, fasting blood glucose, and homeostasis model assessment of insulin resistance. The risk for MetS was significantly higher in subjects with midnight salivary cortisol levels ≥100 ng/dL than in those with levels <50 ng/dL (odds ratio, 5.9; 95% confidence interval, 2.35 to 36.4).

Conclusion

The results showed a positive correlation between midnight salivary cortisol levels and MetS, suggesting that hypercortisolism may be related to MetS.

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    Journal of Cancer Research and Therapeutics.2023;[Epub]     CrossRef
  • Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review
    Francis Osei, Andrea Block, Pia-Maria Wippert
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients
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    Endocrine.2020; 70(2): 404.     CrossRef
  • Basal cortisol levels and metabolic syndrome: A systematic review and meta-analysis of observational studies
    Anderson Garcez, Heloísa Marquardt Leite, Elisabete Weiderpass, Vera Maria Vieira Paniz, Guilherme Watte, Raquel Canuto, Maria Teresa Anselmo Olinto
    Psychoneuroendocrinology.2018; 95: 50.     CrossRef
  • Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity–insulin resistance?
    Jitjiroj Ittichaicharoen, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Archives of Oral Biology.2016; 64: 61.     CrossRef
  • The Role of Cortisol in the Pathogenesis of the Metabolic Syndrome
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2012; 36(3): 207.     CrossRef
Letter
Response
Response: Impact of HbA1c Criterion on the Detection of Subjects with Increased Risk for Diabetes among Health Check-Up Recipients in Korea (Diabetes Metab J 2012;36:151-6)
Hong-Kyu Kim, Sung-Jin Bae, Jaewon Choe
Diabetes Metab J. 2012;36(3):253-253.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.253
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Diabetes Metab J : Diabetes & Metabolism Journal