Table 1Changes in FPG and HbA1c in IGC group before DAA, 3 months after therapy
Variable |
IGC group (n=292) |
NIGC group (n=86) |
Control group (n=60) |
Before DAAs therapy |
3 Months after therapy |
Before DAAs therapy |
3 Months after therapy |
Baseline |
After 3 months |
FPG, mg/dL |
|
|
|
|
|
|
Range |
105–252 |
85–186 |
108–248 |
110–249 |
108–245 |
107–248 |
Mean±SD |
184.5±27.9 |
136.5±22.5 |
179.9±25.6 |
181.2±25.9 |
178.1±24.3 |
180.1±26.2 |
HbA1c, % |
|
|
|
|
|
|
Range |
6.9–8.7 |
6.4–7.7 |
6.8–8.8 |
6.8–8.7 |
6.9–8.8 |
6.8–8.9 |
Mean±SD |
8.1±0.44 |
7.3±0.34 |
8.2±0.48 |
8.1±0.46 |
8.2±0.43 |
8.3±0.46 |
Table 2Comparison between IGC group and NIGC group as regards age, sex, BMI, duration of T2DM, family history of T2DM, and Child-Pugh classification
Variable |
IGC group (n=292) |
NIGC group (n=86) |
P valuea
|
Age, yr |
53.25±4.6 |
52.34±4.9 |
0.113b
|
BMI before therapy, kg/m2
|
27.76±2.7 |
27.24±2.98 |
0.130b
|
BMI after therapy, kg/m2
|
27.74±2.8 |
27.25±3.0 |
0.156b
|
Duration of T2DM, yr |
9.41±4.69 |
13.24±4.25 |
0.001b
|
Sex |
|
|
0.632c
|
Male |
141 (48.3) |
39 (45.3) |
Female |
151 (51.7) |
47 (54.7) |
Family history of T2DM |
|
|
0.001c
|
Positive |
125 (42.8) |
58 (67.4) |
Negative |
167 (57.2) |
28 (32.6) |
Child-Pugh classification |
|
|
0.021c
|
A |
254 (87.0) |
66 (76.7) |
B |
38 (13.0) |
20 (23.3) |
Table 3Multivariate logistic regression analysis for factors affected glycemic control with direct-acting antiviral agents
Factor |
B |
P value |
Odds ratio |
95% CI |
Duration of T2DM (<7 years) |
0.479 |
0.000 |
2.452 |
1.335–4.504 |
Child-Pugh classification (child A) |
0.407 |
0.001 |
2.025 |
1.106–3.711 |
Family history of T2DM (negative) |
0.916 |
0.000 |
2.767 |
1.667–4.595 |