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Review Insulin Resistance in Polycystic Ovary Syndrome.
Yeon Ah Sung
Diabetes & Metabolism Journal 2008;32(1):1-6
Published online: February 1, 2008
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Department of Internal Medicine, Ewha Womans University School of Medicine, Korea.

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age and now recognized as an important metabolic and reproductive disorder. The majority of women with PCOS have insulin resistance and this is regarded to have a central etiological role in PCOS. Insulin resistance and concomitant hyperinsulinemia modifies reproductive function by driving androgen production, suppression of sex hormone-binding globulin (SHBG) and disruption of insulin signaling pathways in the central nervous system. Insulin resistance, together with defects in insulin secretion, confers markedly increased risk for type 2 diabetes mellitus and metabolic syndrome. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and preserved other actions. Genetic and environmental abnormalities interact to produce peripheral insulin resistance in PCOS. The numerous in vivo and in vitro data supporting the central role of insulin resistance in the pathogenesis of PCOS have led a new therapy for PCOS with insulin-sensitizing agents.

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    • Citation for the content below
    Insulin Resistance in Polycystic Ovary Syndrome.
    Korean Diabetes J. 2008;32(1):1-6.   Published online February 1, 2008
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Sung YA. Insulin Resistance in Polycystic Ovary Syndrome.. Diabetes Metab J. 2008;32(1):1-6.

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