Diabetes & Metabolism Journal

Original Articles

Epidemiology
Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population: So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee-Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim; Diabetes Metab J. 2016;40(5):367-375. Published online July 26, 2016; DOI: https://doi.org/10.4093/dmj.2016.40.5.367

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Abstract PDF Supplementary Material PubReader

Background

We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population.

Methods

We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile.

Results

Compared to those in the highest tertile (≥14.3 ng/mL), the odds ratio (OR) for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86) for the 1st tertile (<9.7 ng/mL) and 1.19 (95% CI, 0.08 to 1.62) for the 2nd tertile (9.7 to 14.3 ng/mL) after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56).

Conclusion

Serum 25(OH)D has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.

Citations

Citations to this article as recorded by

Vitamin D and Cardiovascular Diseases: An Update
Farrookh Haider, Hashsaam Ghafoor, Omar F Hassan, Khalid Farooqui, Ali O. Mohamed Bel Khair, Faryal Shoaib
Cureus.2023;[Epub] CrossRef
Vitamin D as predictor Marker of kidney disease in males with type 2 diabetes mellitus
Abeer J. Hassan, Sarmad Ajeel Hazzaa, Dunya Najim Alden Ahmed
Bionatura.2022; 7(2): 1. CrossRef
Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver
Kokab Namakin, Mahya Hosseini, Mahmoud Zardast, Mahyar Mohammadifard
Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(2): 187. CrossRef
The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter
Nam Ju Heo, Hyo Eun Park, Ji Won Yoon, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Jeong Yoon Yim, Goh Eun Chung
Journal of Clinical Medicine.2021; 10(12): 2611. CrossRef
Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)—a population-based study
Bo Wan, Yuan Gao, Yushan Zheng, Ruanqin Chen
Endocrine Journal.2021; 68(6): 631. CrossRef
Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience
Vincenzo Pilone, Salvatore Tramontano, Carmen Cutolo, Federica Marchese, Antonio Maria Pagano, Federica Di Spirito, Luigi Schiavo
International Journal for Vitamin and Nutrition Research.2020; 90(3-4): 346. CrossRef
Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
Yonsei Medical Journal.2019; 60(8): 804. CrossRef
Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Hyeon Chang Kim
Epidemiology and Health.2017; 39: e2017016. CrossRef
Vitamin D and coronary atherosclerosis
Dae Jung Kim
Osteoporosis and Sarcopenia.2017; 3(4): 201. CrossRef

Effects of Vitamin D and Calcium Intervention on the Improvement of Resistance in Patients with Type 2 Diabetes Mellitus.: Young Mee Choi, Jun Ho Lee, Ji Sook Han; Korean Diabetes J. 2009;33(4):324-334. Published online August 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.4.324

2,516 View
46 Download
6 Crossref

Abstract PDF

BACKGROUND
Recent reports suggest that the intake of vitamin D and calcium may influence insulin resistance. The aim of this study was to assess the effects of vitamin D and calcium intervention on the improvement of blood glucose and insulin resistance in patients with type 2 diabetes mellitus (DM). METHODS: Fasting blood glucose, glycosylated hemoglobin A1c (HbA1C), serum 25(OH)D3, serum lipid levels, insulin secretion, and activity and dietary surveys were analyzed in type 2 DM patients both before and after a 12-week vitamin D and calcium intake intervention. RESULTS: The serum 25(OH)D3 level was found to be negatively correlated with insulin resistance and fasting blood glucose. Calcium intake level was also negatively correlated with insulin resistance. Fasting blood glucose, HbA1C, and HOMA-IR decreased significantly (P <0.05) following vitamin D and calcium intake intervention in the medical nutrition therapy (MNT) group, while there was no such change observed in the control group. Dietary calcium and vitamin D intakes were significantly (P <0.05) higher in the MNT group than in the control group. The concentrations of serum 25(OH)D3 and insulin secretion increased slightly in the MNT group following the 12-week intervention; however, these results did not reach statistical significance. CONCLUSION: The results of the present study indicate that calcium and vitamin D intervention may be helpful in improving fasting blood glucose, HbA1C, serum 25(OH)D3 and HOMA-IR in patients with type 2 DM who have insufficient serum 25(OH)D3 concentrations.

Citations

Citations to this article as recorded by

Comparison of Biological Markers and Lifestyle Factors on the Presence of Diabetes Mellitus in Middle-aged adults
Hye-Sun Keum, Soon-Rim Suh
Journal of the Korea Academia-Industrial cooperation Society.2016; 17(2): 104. CrossRef
A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea
Ohk-Hyun Ryu, Sungwha Lee, Jaemyung Yu, Moon-Gi Choi, Hyung Joon Yoo, Franco Mantero
Endocrine Journal.2014; 61(2): 167. CrossRef
A Study of Snack Consumption, Night-Eating Habits, and Nutrient Intake in Gestational Diabetes Mellitus
Hee-jin Park, JinJu Lee, Ji-Myung Kim, Hyun Ah Lee, Sung-Hoon Kim, Yuri Kim
Clinical Nutrition Research.2013; 2(1): 42. CrossRef
Vitamin D and Diabetes
Dallae Ju
Journal of Korean Diabetes.2011; 12(2): 104. CrossRef
Nutrients and Dish Intake by Fasting Blood Glucose Level
Jihyun Choi, Hyun-Kyung Moon
The Korean Journal of Nutrition.2010; 43(5): 463. CrossRef
Vitamin D and Diabetes Mellitus
Jung Hyun Noh
Korean Diabetes Journal.2009; 33(4): 276. CrossRef

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