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Diabetes Metab J : Diabetes & Metabolism Journal



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Brief Report
A Potential Issue with Screening Prediabetes or Diabetes Using Serum Glucose: A Delay in Diagnosis
Jun Goo Kang, Cheol-Young Park, Sung-Hee Ihm, Sung Woo Park
Diabetes Metab J. 2016;40(5):414-417.   Published online September 1, 2016
  • 3,668 View
  • 51 Download
  • 11 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   

The aim of this study was to compare the fasting serum glucose level with the fasting plasma glucose level for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay in sample processing and how such delays can impact the diagnosis of hyperglycemic states. Among 1,254 participants who had normoglycemia or impaired fasting glucose (IFG) assessed by the fasting serum glucose level, 20.9% were newly diagnosed with diabetes based on the plasma fasting glucose level. Of the participants with normoglycemia, 62.1% and 14.2% were newly diagnosed with IFG and diabetes, respectively, according to the plasma fasting glucose level. In our clinical laboratory for performing health examinations, the time delay from blood sampling to glycemic testing averaged 78±52 minutes. These findings show that the ordinary time delay for sample processing of the serum glucose for screening hyperglycemic states may be an important reason for these diagnoses to be underestimated in Korea.


Citations to this article as recorded by  
  • Comparing glycemic traits in defining diabetes among rural Chinese older adults
    Pin Wang, Yuanjing Li, Mingqi Wang, Lin Song, Yi Dong, Xiaolei Han, Jaakko Tuomilehto, Yongxiang Wang, Yifeng Du, Chengxuan Qiu, Fredirick Lazaro mashili
    PLOS ONE.2024; 19(1): e0296694.     CrossRef
  • Serum glucose, a cost-effective alternate of plasma glucose in diagnosing and monitoring diabetes mellitus
    Vivek Pant, Anders Kallner
    International Journal of Diabetes in Developing Countries.2023; 43(3): 377.     CrossRef
  • Hyperglycemia and prematurity: a narrative review
    Dimitrios Angelis, Mambarambath A. Jaleel, Luc P. Brion
    Pediatric Research.2023; 94(3): 892.     CrossRef
  • Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
    Kanyin Liane Ong, Lauryn K Stafford, Susan A McLaughlin, Edward J Boyko, Stein Emil Vollset, Amanda E Smith, Bronte E Dalton, Joe Duprey, Jessica A Cruz, Hailey Hagins, Paulina A Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mo
    The Lancet.2023; 402(10397): 203.     CrossRef
  • PM2.5 exposure increases the risk of preterm birth in pre-pregnancy impaired fasting glucose women: A cohort study in a Southern province of China
    Zhijiang Liang, Lina Zhao, Jialing Qiu, Xinhong Zhu, Min Jiang, Guocheng Liu, Qingguo Zhao
    Environmental Research.2022; 204: 112403.     CrossRef
  • The impact of maternal prepregnancy impaired fasting glucose on preterm birth and large for gestational age: a large population-based cohort study
    Jie Tang, Xinhong Zhu, Mingzhen Li, Dongming Huang, Qingguo Zhao
    American Journal of Obstetrics and Gynecology.2020; 222(3): 265.e1.     CrossRef
  • Utility of point‐of‐care vs reference laboratory testing for the evaluation of glucose levels
    O. M. Andriankaja, F. J. Muñoz‐Torres, J. L. Vergara, C. M. Pérez, K. Joshipura
    Diabetic Medicine.2019; 36(5): 626.     CrossRef
  • Pre-analytical factors in blood glucose measurement
    Alpesh Goyal, Yashdeep Gupta
    Diabetes Research and Clinical Practice.2019; 158: 107802.     CrossRef
  • Long-term stability of glucose: glycolysis inhibitor vs. gel barrier tubes
    Theresa Winter, Anke Hannemann, Juliane Suchsland, Matthias Nauck, Astrid Petersmann
    Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(8): 1251.     CrossRef
  • Blood Glucose Measurement: Is Serum Equal to Plasma?
    Hye Soon Kim
    Diabetes & Metabolism Journal.2016; 40(5): 365.     CrossRef
Original Article
Investigating Susceptibility to Diabetes Using Features of the Adipose Tissue in Response to In Utero Polycyclic Aromatic Hydrocarbons Exposure
Worlanyo E. Gato, Daniel A. Hunter, Shamaya L. Whitby, Christopher A. Mays, Wilson Yau
Diabetes Metab J. 2016;40(6):494-508.   Published online August 12, 2016
  • 3,922 View
  • 92 Download
  • 7 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   

In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability. 2AA is a polycyclic aromatic hydrocarbon found in a variety of products.


To accomplish the study objective, pregnant dams were fed various amounts of 2AA adulterated diets from gestation through postnatal period. The neonates and older offspring were analyzed for diabetic-like genes in the ATs and analysis of serum glucose. Furthermore, weight monitoring, histopathology and immunohistochemical (IHC) staining for CD68 in AT, adipocyte size determination and adiponectin amounts in serum were undertaken.


Up-regulation of adiponectin and interleukin-6 genes were noted in the pups and older rats. Combination of intrauterine 2AA toxicity with moderate high fat diet exhibited gene expression patterns similar to those of the neonates. Elevated serum glucose levels were noted in treated groups. IHC of the AT indicated no significant malformations; however, CD68+ cells were greater in the animals treated to 2AA. Similarly, mean sizes of the adipocytes were larger in treated and combined 2AA and moderate high fat animals. Adiponectin was reduced in 2AA groups.


From the preceding, it appears intrauterine 2AA disturbance, when combined with excess fat accumulation will lead to greater risk for the diabetic condition.


Citations to this article as recorded by  
  • The Role of Persistent Organic Pollutants in Obesity: A Review of Laboratory and Epidemiological Studies
    Jan Aaseth, Dragana Javorac, Aleksandra Djordjevic, Zorica Bulat, Anatoly Skalny, Irina Zaitseva, Michael Aschner, Alexey Tinkov
    Toxics.2022; 10(2): 65.     CrossRef
  • The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus
    Xue Wang, Ang Li, Qun Xu
    International Journal of Environmental Research and Public Health.2022; 19(13): 7605.     CrossRef
  • Dietary ingestion of 2-aminoanthracene (2AA) and the risk for type-1 diabetes (T1D)
    Isaiah Seise, Zachary A. Pilz, Moses Yeboah Kusi, Bethany Bogan, Brittany Jean McHale, Worlanyo E. Gato
    Journal of Environmental Science and Health, Part A.2020; 55(14): 1638.     CrossRef
  • Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects
    Elham Barati, Hamideh Ghazizadeh, Fatemeh Sadabadi, Elham Kazemi, Gordon A. Ferns, Amir Avan, Majid Ghayour-Mobarhan
    Biochemical Genetics.2019; 57(5): 695.     CrossRef
  • The hepatic effects in dams that ingested 2-aminoanthracene during gestation and lactation
    Raven E Ulieme, Surjania Awer, John C Stagg, Wilson Yau, Worlanyo E Gato
    Toxicology and Industrial Health.2019; 35(9): 568.     CrossRef

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