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Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
Diabetes Metab J. 2024;48(3):405-417.   Published online February 1, 2024
DOI: https://doi.org/10.4093/dmj.2023.0196
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  • 2 Web of Science
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury. The present study investigated the role of pyruvate dehydrogenase kinase 4 (PDK4) in ROS production and inflammation following IR injury.
Methods
We used a streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected to IR by clamping both renal pedicles. Cellular apoptosis and inflammatory markers were evaluated in NRK-52E cells and mouse primary tubular cells after hypoxia and reoxygenation using a hypoxia work station.
Results
Following IR injury in diabetic mice, the expression of PDK4, rather than the other PDK isoforms, was induced with a marked increase in pyruvate dehydrogenase E1α (PDHE1α) phosphorylation. This was accompanied by a pronounced ROS activation, as well as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) production. Notably, sodium dichloroacetate (DCA) attenuated renal IR injury-induced apoptosis which can be attributed to reducing PDK4 expression and PDHE1α phosphorylation levels. DCA or shPdk4 treatment reduced oxidative stress and decreased TNF-α, IL-6, IL-1β, and MCP-1 production after IR or hypoxia-reoxygenation injury.
Conclusion
PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.

Citations

Citations to this article as recorded by  
  • Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury
    Jaemin Lee
    Diabetes & Metabolism Journal.2024; 48(3): 385.     CrossRef
  • Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
    Seahyoung Lee
    Antioxidants.2024; 13(6): 656.     CrossRef
Reviews
Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
Nam Ho Jeoung
Diabetes Metab J. 2015;39(3):188-197.   Published online June 15, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.3.188
  • 7,675 View
  • 153 Download
  • 110 Web of Science
  • 99 Crossref
AbstractAbstract PDFPubReader   

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to acetyl-CoA. Tight control of PDC is critical because it plays a key role in glucose disposal. PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns, kinetic properties, and sensitivities to regulatory molecules. During the last decades, the up-regulation of PDKs has been observed in the tissues of patients and mammals with metabolic diseases, which suggests that the inhibition of these kinases may have beneficial effects for treating metabolic diseases. This review summarizes the recent advances in the role of specific PDK isoenzymes on the induction of metabolic diseases and describes the effects of PDK inhibition on the prevention of metabolic diseases using pharmacological inhibitors. Based on these reports, PDK isoenzymes are strong therapeutic targets for preventing and treating metabolic diseases.

Citations

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  • Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
    Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu
    The Journal of Infectious Diseases.2024; 229(4): 1178.     CrossRef
  • Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria
    Konstantin S. Plokhikh, Semen V. Nesterov, Yuriy M. Chesnokov, Anton G. Rogov, Roman A. Kamyshinsky, Aleksandr L. Vasiliev, Lev S. Yaguzhinsky, Raif G. Vasilov
    The FEBS Journal.2024; 291(1): 132.     CrossRef
  • Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
    Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha
    International Journal of Molecular Sciences.2024; 25(2): 807.     CrossRef
  • Gamut of glycolytic enzymes in vascular smooth muscle cell proliferation: Implications for vascular proliferative diseases
    Ankan Sarkar, Sandip V. Pawar, Kanwaljit Chopra, Manish Jain
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(3): 167021.     CrossRef
  • Recent advances in pyruvate dehydrogenase kinase inhibitors: Structures, inhibitory mechanisms and biological activities
    Yiyang Li, Zhizhong Xie, Xiaoyong Lei, Xiaoyan Yang, Sheng Huang, Weixi Yuan, Xiangping Deng, Zhe Wang, Guotao Tang
    Bioorganic Chemistry.2024; 144: 107160.     CrossRef
  • Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments
    Jianda Yue, Jiawei Xu, Yekui Yin, Yuanyuan Shu, Yaqi Li, Tingting Li, Zirui Zou, Zihan Wang, Fengjiao Li, Mengqi Zhang, Songping Liang, Xiao He, Zhonghua Liu, Ying Wang
    International Journal of Biological Macromolecules.2024; 262: 129970.     CrossRef
  • Metabolic regulation of skeletal cell fate and function
    Steve Stegen, Geert Carmeliet
    Nature Reviews Endocrinology.2024; 20(7): 399.     CrossRef
  • Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer
    Wonyoung Park, Shibo Wei, Chu-Long Xie, Jung Ho Han, Bo-Sung Kim, Bosung Kim, Jung-Sook Jin, Eun-Sun Yang, Min Kyoung Cho, Dongryeol Ryu, Hao-Xian Yang, Sung-Jin Bae, Ki-Tae Ha
    Experimental & Molecular Medicine.2024; 56(5): 1137.     CrossRef
  • Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase
    Masafumi Inoue, Hironobu Nagamori, Toru Morita, Satoru Kobayashi, Koichi Suzawa, Yuki Kitao, Tomoyuki Saito, Iichiro Kawahara, Takuya Orita, Shota Akai, Tsuyoshi Adachi, Takahisa Motomura
    Bioorganic & Medicinal Chemistry Letters.2024; 109: 129839.     CrossRef
  • Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
    Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
    Diabetes & Metabolism Journal.2024; 48(3): 405.     CrossRef
  • Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads
    Yuejiao Wang, Xue Wang, Chaoqi Du, Zeming Wang, Jiahui Wang, Nan Zhou, Baohua Wang, Ke Tan, Yumei Fan, Pengxiu Cao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Research into how carvacrol and metformin affect several human proteins in a hyperglycemic condition: A comparative study in silico and in vitro
    Nail Besli, Nilufer Ercin, Miguel Carmena-Bargueño, Bahar Sarikamis, Rabia Kalkan Cakmak, Guven Yenmis, Horacio Pérez-Sánchez, Merve Beker, Ulkan Kilic
    Archives of Biochemistry and Biophysics.2024; 758: 110062.     CrossRef
  • Glycolysis, the sweet appetite of the tumor microenvironment
    Zeinab Kooshan, Lilibeth Cárdenas-Piedra, Judith Clements, Jyotsna Batra
    Cancer Letters.2024; 600: 217156.     CrossRef
  • Anaerobic Glycolysis and Ischemic Stroke: From Mechanisms and Signaling Pathways to Natural Product Therapy
    Jia Pu, Jin Han, Jiehong Yang, Li Yu, Haitong Wan
    ACS Chemical Neuroscience.2024; 15(17): 3090.     CrossRef
  • Effective strategies alleviate mitochondrial toxicity of perfluorooctanoic acid: Modification of functional head group and inhibition of toxic target
    Ruijia Zhang, Lanyin Tu, Yingshi Lin, Jiahui Liu, Tong Liang, Wenhua Lu, Baowei Chen, Tiangang Luan
    Journal of Hazardous Materials.2024; 479: 135733.     CrossRef
  • MicroRNA-382 as a tumor suppressor during tumor progression
    Yalda Samsami, Iman Akhlaghipour, Negin Taghehchian, Mahsa Palizkaran Yazdi, Saba Farrokhi, Hamid Reza Rahimi, Meysam Moghbeli
    Bioorganic & Medicinal Chemistry Letters.2024; 113: 129967.     CrossRef
  • Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
    Hui-fang Zhang, Hui-ming Liu, Jia-yi Xiang, Xing-cheng Zhou, Dan Wang, Rong-yu Chen, Wan-lin Tan, Lu-qun Liang, Ling-ling Liu, Ming-jun Shi, Fan Zhang, Ying Xiao, Yu-xia Zhou, Tian Zhang, Lei Tang, Bing Guo, Yuan-yuan Wang
    Acta Pharmacologica Sinica.2023; 44(5): 1051.     CrossRef
  • Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer
    Weijing He, Qingguo Li, Xinxiang Li
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(1): 188837.     CrossRef
  • Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3
    Kehinde S. Olaniyi, Stephanie E. Areloegbe
    Nutrition.2023; 107: 111914.     CrossRef
  • Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines
    Lijun Gong, Fang Wei, Frank J. Gonzalez, Guolin Li
    Hepatology.2023; 78(5): 1625.     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors
    Deniz Arslan, Matthieu Schoumacher, Sébastien Dilly, Benaïssa Elmoualij, Danièle Zorzi, Pascale Quatresooz, Vincent Lambert, Agnès Noël, Bernard Pirotte, Pascal de Tullio
    Medicinal Chemistry.2023; 19(3): 276.     CrossRef
  • AP2α negatively regulates PDHA1 in cervical cancer cells to promote aggressive features and aerobic glycolysis in vitro and in vivo
    Lijie Zhao, Rong Geng, Yi Huang, Jiping Zhang, Haiying Cheng, Cankun Zhou, Yifeng Wang
    Journal of Gynecologic Oncology.2023;[Epub]     CrossRef
  • Pyruvate dehydrogenase kinase inhibitor dichloroacetate augments autophagy mediated constraining the replication of Mycobacteroides massiliense in macrophages
    Hailian Quan, Hyewon Chung, Sungmo Je, Jung Joo Hong, Bum-Joon Kim, Yi Rang Na, Seung Hyeok Seok
    Microbes and Infection.2023; 25(7): 105139.     CrossRef
  • Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
    Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan
    Blood Advances.2023; 7(11): 2347.     CrossRef
  • Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue
    Zhi-Hong Wen, Chun-Sung Sung, Sung-Chun Lin, Zhi-Kang Yao, Yu-Cheng Lai, Yu-Wei Liu, Yu-Yan Wu, Hsi-Wen Sun, Hsin-Tzu Liu, Wu-Fu Chen, Yen-Hsuan Jean
    International Journal of Molecular Sciences.2023; 24(13): 10770.     CrossRef
  • TUG1 protects against ferroptosis of hepatic stellate cells by upregulating PDK4-mediated glycolysis
    Xiangting Zhang, Luying Zhao, Kanglei Ying, Jun Xu, Yangjin Huang, Ruhuang Zhu, Yinrong Ding, Weimin Cai, Xiao Wu, Dan Miao, Qian Xu, Yuan Zeng, Fujun Yu
    Chemico-Biological Interactions.2023; 383: 110673.     CrossRef
  • Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
    Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
    Chenyu Li, Chuanbin Liu, Junfeng Zhang, Yanyu Lu, Bingtong Jiang, Huabao Xiong, Chunxia Li
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Implications of tempol in pyruvate dehydrogenase kinase 3 targeted anticancer therapeutics: Computational, spectroscopic, and calorimetric studies
    Saleha Anwar, Debarati DasGupta, Alaa Shafie, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Moyad Shahwan, Farah Anjum, Waleed Al Abdulmonem, Sharaf E. Sharaf, Md. Imtaiyaz Hassan
    Journal of Molecular Liquids.2022; 350: 118581.     CrossRef
  • Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect
    Mohamed A. Nassan, Adil Aldhahrani, Hamada H. Amer, Ahmed Elhenawy, Ayman A. Swelum, Omar M. Ali, Yasser H. Zaki
    Molecules.2022; 27(3): 756.     CrossRef
  • An enzyme-responsive and NIR-triggered lipid–polymer hybrid nanoplatform for synergistic photothermal/chemo cancer therapy
    Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
    Biomaterials Science.2022; 10(9): 2370.     CrossRef
  • BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway
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    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
    Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
    Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
  • Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs
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    Cells.2022; 11(19): 2973.     CrossRef
  • PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level
    Yan Song, Juan Zhang, Lei Zhang, Suxia Zhang, Chengcheng Shen, Jincheng Wang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Changes in the Expression of Pyruvate Dehydrogenase Kinase Isoenzymes During Early Differentiation of Mouse Embryonic Stem Cells
    Saime GÜZEL
    Journal of Research in Veterinary Medicine.2022; 41(2): 92.     CrossRef
  • Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation
    Sunil Poudel, Gil Martins, M. Leonor Cancela, Paulo J. Gavaia
    International Journal of Molecular Sciences.2022; 23(23): 15160.     CrossRef
  • Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer
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    Journal of Biomolecular Structure and Dynamics.2021; 39(2): 586.     CrossRef
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    International Journal of Molecular Sciences.2021; 22(2): 764.     CrossRef
  • BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
    Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
    Developmental Cell.2021; 56(8): 1182.     CrossRef
  • Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
    Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li
    Bioscience Reports.2021;[Epub]     CrossRef
  • Identification of differentially expressed genes and the role of PDK4 in CD14+ monocytes of coronary artery disease
    Pei Du, Ren Guo, Keqin Gao, Shuang Yang, Baige Yao, Haobo Cui, Ming Zhao, Sujie Jia
    Bioscience Reports.2021;[Epub]     CrossRef
  • Radiation-Induced Metabolic Shifts in the Hepatic Parenchyma: Findings from 18F-FDG PET Imaging and Tissue NMR Metabolomics in a Mouse Model for Hepatocellular Carcinoma
    Yi-Hsiu Chung, Cheng-Kun Tsai, Ching-Fang Yu, Wan-Ling Wang, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen, Gigin Lin
    Molecules.2021; 26(9): 2573.     CrossRef
  • Long non-coding RNA AFAP1-AS1 facilitates ovarian cancer progression by regulating the miR-107/PDK4 axis
    Bao Liu, Li Yan, Yugang Chi, Yuhan Sun, Xiaoyu Yang
    Journal of Ovarian Research.2021;[Epub]     CrossRef
  • Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
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    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568.     CrossRef
  • Metabolic Alterations in Sepsis
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  • Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex
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    Cell Death & Disease.2021;[Epub]     CrossRef
  • circ_0005962 functions as an oncogene to aggravate NSCLC progression
    Zhihong Zhang, Zhenxiu Shan, Rubin Chen, Xiaorong Peng, Bin Xu, Liang Xiao, Guofei Zhang
    Open Medicine.2021; 16(1): 997.     CrossRef
  • Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways
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    Aging.2021; 13(17): 21155.     CrossRef
  • Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis
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    Molecular and Cellular Biology.2021;[Epub]     CrossRef
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    Journal of Applied Oral Science.2021;[Epub]     CrossRef
  • Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
    I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva
    Cellular and Molecular Life Sciences.2021; 78(23): 7451.     CrossRef
  • Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells
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    BMB Reports.2021; 54(11): 563.     CrossRef
  • Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area
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    International Journal of Molecular Sciences.2021; 22(23): 13068.     CrossRef
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    International Journal of Molecular Sciences.2020; 21(17): 6021.     CrossRef
  • Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy
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    Cancers.2020; 12(1): 181.     CrossRef
  • Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
    Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • STAT3‐dependent analysis revealsPDK4as independent predictor of recurrence in prostate cancer
    Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger, Jan Pencik, Petra Kodajova, Sandra Högler, Georg Stockmaier, Sandra Grund‐Gröschk
    Molecular Systems Biology.2020;[Epub]     CrossRef
  • Differential effects of metformin on reductive activity and energy production in pituitary tumor cells compared to myogenic precursors
    Giovanni Tulipano, Simone Paghera, Cristina Missale, Andrea Giustina
    Endocrine.2020; 69(3): 604.     CrossRef
  • Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
    Xiqiong Han, Wenqi Ma, Yi Zhu, Xuejiao Sun, Naifeng Liu
    Molecular and Cellular Endocrinology.2020; 514: 110878.     CrossRef
  • Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells
    Giovanni Tulipano, Andrea Giustina
    Pituitary.2020; 23(3): 223.     CrossRef
  • Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
    Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
    Cancer & Metabolism.2020;[Epub]     CrossRef
  • miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer
    Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li
    Molecular Therapy - Oncolytics.2020; 17: 509.     CrossRef
  • Bayesian variable selection for high dimensional predictors and self-reported outcomes
    Xiangdong Gu, Mahlet G Tadesse, Andrea S Foulkes, Yunsheng Ma, Raji Balasubramanian
    BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
  • Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?
    Jordy M. M. Kocken, Paula A. da Costa Martins
    International Journal of Molecular Sciences.2020; 21(23): 8901.     CrossRef
  • Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
    Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha
    Scientific Reports.2020;[Epub]     CrossRef
  • Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
    Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Ri
    eLife.2019;[Epub]     CrossRef
  • Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
    Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
    Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
  • Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
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    European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells
    Rokibul Islam, Jae-Gyu Kim, Yohan Park, Jung-Yoon Cho, Kim-Cuong Cap, A-Ra Kho, Won-Suk Chung, Sang-Won Suh, Jae-Bong Park
    The FASEB Journal.2019; 33(2): 2072.     CrossRef
  • ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts
    Tatsufumi Goto, Kumi Ubukawa, Isuzu Kobayashi, Kotomi Sugawara, Ken Asanuma, Yumi Sasaki, Yong-Mei Guo, Naoto Takahashi, Kenichi Sawada, Hideki Wakui, Wataru Nunomura
    Experimental Hematology.2019; 72: 14.     CrossRef
  • Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity
    Choong-Hwan Kwak, Jung-Hee Lee, Eun-Yeong Kim, Chang Woo Han, Keuk-Jun Kim, Hanna Lee, MyoungLae Cho, Se Bok Jang, Cheorl-Ho Kim, Tae-Wook Chung, Ki-Tae Ha
    Cancers.2019; 11(5): 712.     CrossRef
  • Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server
    Andreia S.P. Pereira, Helena den Haan, Jorge Peña-García, Marién M. Moreno, Horacio Pérez-Sánchez, Zeno Apostolides
    Molecules.2019; 24(10): 2002.     CrossRef
  • Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
    Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez, Zeno Apostolides
    Molecules.2019; 24(22): 4030.     CrossRef
  • Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
    Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
    Cells.2019; 8(11): 1449.     CrossRef
  • Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
    Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
    Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
  • Molecular interactions underpinning the phenotype of hibernation in mammals
    Matthew T. Andrews
    Journal of Experimental Biology.2019;[Epub]     CrossRef
  • Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma
    Surangkana Sanmai, Tanakorn Proungvitaya, Temduang Limpaiboon, Daraporn Chua‑On, Wunchana Seubwai, Sittiruk Roytrakul, Sopit Wongkham, Chaisiri Wongkham, Ongart Somintara, Sakkarn Sangkhamanon, Siriporn Proungvitaya
    Oncology Letters.2019;[Epub]     CrossRef
  • Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells
    Li Xie, Junqing Miao, Xiangchao Li, Xiaoping Yi, Ju Chu
    RSC Advances.2019; 9(61): 35760.     CrossRef
  • Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
    F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
    Oncogene.2018; 37(8): 1062.     CrossRef
  • Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
    Lise Van Wyngene, Jolien Vandewalle, Claude Libert
    EMBO Molecular Medicine.2018;[Epub]     CrossRef
  • Effects of β-caryophyllene on arginine ADP-ribosyltransferase 1-mediated regulation of glycolysis in colorectal cancer under high-glucose conditions
    Li Zhou, Mu-Lu Zhan, Yi Tang, Ming Xiao, Ming Li, Qing-Shu Li, Lian Yang, Xian Li, Wen-Wen Chen, Ya-Lan Wang
    International Journal of Oncology.2018;[Epub]     CrossRef
  • PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
    Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
    Diabetes.2018; 67(10): 2054.     CrossRef
  • Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer
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    Oncotarget.2017; 8(68): 112841.     CrossRef
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  • Spatial Organization of Metabolic Enzyme Complexes in Cells
    Danielle L. Schmitt, Songon An
    Biochemistry.2017; 56(25): 3184.     CrossRef
  • Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells
    Wenjia Zhang, Jing Su, Huadan Xu, Shanshan Yu, Yanan Liu, Yong Zhang, Liankun Sun, Ying Yue, Xiaoli Zhou, Aamir Ahmad
    PLOS ONE.2017; 12(6): e0179672.     CrossRef
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    Rejuvenation Research.2017; 20(4): 263.     CrossRef
  • Regulation of pyruvate dehydrogenase (PDH) in the hibernating ground squirrel, ( Ictidomys tridecemlineatus )
    Sanoji Wijenayake, Shannon N. Tessier, Kenneth B. Storey
    Journal of Thermal Biology.2017; 69: 199.     CrossRef
  • Nuclear localization of metabolic enzymes in immunity and metastasis
    Yuchen He, Menghui Gao, Yiqu Cao, Haosheng Tang, Shuang Liu, Yongguang Tao
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(2): 359.     CrossRef
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    Nutrients.2016; 8(12): 772.     CrossRef
  • Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
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    Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
  • Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
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    Scientific Reports.2016;[Epub]     CrossRef
  • Drugs that Affect Cardiac Metabolism: Focus on Perhexiline
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    Cardiovascular Drugs and Therapy.2016; 30(4): 399.     CrossRef
  • Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
    Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
    International Journal of Molecular Sciences.2016; 17(3): 340.     CrossRef
  • Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
    Camille Lehuédé, Fanny Dupuy, Rebecca Rabinovitch, Russell G. Jones, Peter M. Siegel
    Cancer Research.2016; 76(18): 5201.     CrossRef
Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee
Diabetes Metab J. 2012;36(5):328-335.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.328
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AbstractAbstract PDFPubReader   

The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it has been reported that PDC is phosphorylated and inactivated by PDK2 and PDK4 in metabolically active tissues including liver, skeletal muscle, heart, and kidney during starvation and diabetes, the precise mechanisms by which expression of PDK2 and PDK4 are transcriptionally regulated still remains unclear. Insulin represses the expression of PDK2 and PDK4 via phosphorylation of FOXO through PI3K/Akt signaling pathway. Several nuclear hormone receptors activated due to fasting or increased fat supply, including peroxisome proliferator-activated receptors, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors, also participate in the up-regulation of PDK2 and PDK4; however, the endogenous ligands that bind those nuclear receptors have not been identified. It has been recently suggested that growth hormone, adiponectin, epinephrine, and rosiglitazone also control the expression of PDK4 in tissue-specific manners. In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.

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    BMC Sports Science, Medicine and Rehabilitation.2024;[Epub]     CrossRef
  • Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOS
    Ling Hong, Shan Xiao, Lianghui Diao, Ruochun Lian, Cong Chen, Yong Zeng, Su Liu
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  • Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes
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    Biological and Pharmaceutical Bulletin.2024; 47(9): 1542.     CrossRef
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    Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju
    BMC Cancer.2023;[Epub]     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
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    Sanjana Kannikeswaran, Daniel G Whitney, Maureen J Devlin, Ying Li, Michelle S Caird, Andrea I Alford
    JBMR Plus.2023;[Epub]     CrossRef
  • Targeting PDK2 rescues stress-induced impaired brain energy metabolism
    Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang
    Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
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    Kidney International.2023; 104(4): 724.     CrossRef
  • High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression
    Pengyu Wei, Dongxu Lin, Changcheng Luo, Mengyang Zhang, Bolang Deng, Kai Cui, Zhong Chen
    Scientific Reports.2023;[Epub]     CrossRef
  • PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression
    Zhouji Ma, Ran Mo, Ping Yang, Youjun Ding, Hao Zhang, Zheng Dong, Yutong Chen, Qian Tan
    The FASEB Journal.2023;[Epub]     CrossRef
  • PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
    Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan
    Cell Death Discovery.2023;[Epub]     CrossRef
  • CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function
    Huimin Niu, Xiayu Ren, Enxue Tan, Xing Wan, Yu Wang, Honghong Shi, Yanjuan Hou, Lihua Wang
    Renal Failure.2023;[Epub]     CrossRef
  • PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
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    Antioxidants & Redox Signaling.2022; 36(7-9): 505.     CrossRef
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    Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li
    Journal of Bioenergetics and Biomembranes.2022; 54(1): 17.     CrossRef
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    Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper
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    Zongling Wang, Lizhi Wang, Lina Dai, Yanan Wang, Erhong Li, Shuyuan An, Fengliang Wang, Dan Liu, Wen Pan
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    Applied Physiology, Nutrition, and Metabolism.2021; 46(4): 299.     CrossRef
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    Kanchan Phadwal, Christina Vrahnas, Ian G. Ganley, Vicky E. MacRae
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  • BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
    Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
    Developmental Cell.2021; 56(8): 1182.     CrossRef
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    BMC Genomics.2021;[Epub]     CrossRef
  • PDK2: An Underappreciated Regulator of Liver Metabolism
    Benjamin L. Woolbright, Robert A. Harris
    Livers.2021; 1(2): 82.     CrossRef
  • Endocrine Influence on Cardiac Metabolism in Development and Regeneration
    Niall Graham, Guo N Huang
    Endocrinology.2021;[Epub]     CrossRef
  • Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas
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  • Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20
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    Cancer Science.2021; 112(9): 3585.     CrossRef
  • Skeletal muscle energy metabolism in obesity
    Abel M. Mengeste, Arild C. Rustan, Jenny Lund
    Obesity.2021; 29(10): 1582.     CrossRef
  • Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
    Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Je
    PLOS Pathogens.2021; 17(10): e1009991.     CrossRef
  • Transcriptional and free radical responses to LVAD therapy
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    Translational Medicine Communications.2020;[Epub]     CrossRef
  • Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
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  • Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply
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    Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
  • Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
    Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall
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    Gastroenterology.2020; 158(6): 1650.     CrossRef
  • The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
    Tao Gao, Dan He, Xin Liu, Fang Ji, Jianhong Xu, Jianrong Shi
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  • PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis
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    Journal of Bone and Mineral Research.2020; 36(3): 553.     CrossRef
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  • Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
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  • PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
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  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
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  • The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
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  • Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
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    Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
  • PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
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    Diabetes.2019; 68(3): 571.     CrossRef
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    Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
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    Biochemical and Biophysical Research Communications.2019; 516(4): 1097.     CrossRef
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    Journal of Biological Chemistry.2019; 294(45): 16831.     CrossRef
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    Mitochondrion.2019; 49: 97.     CrossRef
  • Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
    Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris, John A. Taylor
    Molecular Cancer Therapeutics.2019; 18(10): 1673.     CrossRef
  • Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
    Patricia G. Rosenstein, Brett S. Tennent‐Brown, Dez Hughes
    Journal of Veterinary Emergency and Critical Care.2018; 28(2): 85.     CrossRef
  • SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
    Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S. Atreya, Ullas Kolthur‐Seetharam, Nagalingam R. Sundaresan
    Journal of Cellular Physiology.2018; 233(7): 5478.     CrossRef
  • Metabolic Changes Associated With Muscle Expression of SOD1G93A
    Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musarò
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue
    Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López, María del Mar Romero, Marià Alemany
    PeerJ.2018; 6: e5440.     CrossRef
  • Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
    Lidan Zhao, Ryan P. McMillan, Guohao Xie, Samantha G. L. W. Giridhar, Lance H. Baumgard, Samer El-Kadi, Joshua Selsby, Jason Ross, Nicholas Gabler, Matthew W. Hulver, Robert P. Rhoads
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1096.     CrossRef
  • Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
    Rong Ke, Qicao Xu, Cong Li, Lingyu Luo, Deqiang Huang
    Cell Biology International.2018; 42(4): 384.     CrossRef
  • Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism
    Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu
    Scientific Reports.2018;[Epub]     CrossRef
  • Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
    Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
    Oncotarget.2017; 8(68): 112841.     CrossRef
  • Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
    Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
    Kidney International.2017; 91(4): 880.     CrossRef
  • PPARβ/δ in human cancer
    Rolf Müller
    Biochimie.2017; 136: 90.     CrossRef
  • The physiological and molecular response of Aurelia sp.1 under hypoxia
    Guoshan Wang, Yu Zhen, Zhigang Yu, Yan Shi, Qing Zhao, Jianyan Wang, Tiezhu Mi
    Scientific Reports.2017;[Epub]     CrossRef
  • A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration
    Víctor López del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 801.     CrossRef
  • Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
    Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
    The Journal of Nutritional Biochemistry.2017; 39: 126.     CrossRef
  • Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
    Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier
    PLOS ONE.2017; 12(10): e0186021.     CrossRef
  • Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy
    Sahoko Ichihara, Yuka Suzuki, Jie Chang, Kentaro Kuzuya, Chisa Inoue, Yuki Kitamura, Shinji Oikawa
    Scientific Reports.2017;[Epub]     CrossRef
  • Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
    Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli, Sylvie Bortoli
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Oncogenic role of PDK4 in human colon cancer cells
    D Leclerc, D N T Pham, N Lévesque, M Truongcao, W D Foulkes, C Sapienza, R Rozen
    British Journal of Cancer.2017; 116(7): 930.     CrossRef
  • Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
    Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama
    The Journal of Poultry Science.2017; 54(4): 292.     CrossRef
  • Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
    Peter W Stacpoole
    JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
  • Reference Gene Selection and Prednisolone Target Gene Expression in Adipose Tissues of Friesian Cattle
    Sara Divari, Enrica Berio, Bartolomeo Biolatti, Francesca Tiziana Cannizzo
    Journal of Agricultural and Food Chemistry.2017; 65(50): 11140.     CrossRef
  • Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
    Luana Naia, Teresa Cunha-Oliveira, Joana Rodrigues, Tatiana R. Rosenstock, Ana Oliveira, Márcio Ribeiro, Catarina Carmo, Sofia I. Oliveira-Sousa, Ana I. Duarte, Michael R. Hayden, A. Cristina Rego
    The Journal of Neuroscience.2017; 37(10): 2776.     CrossRef
  • Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
    Mina Kim, Dae Keun Kim, Youn-Soo Cha
    Journal of Medicinal Food.2016; 19(5): 442.     CrossRef
  • Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
    Hana Park, Nam Ho Jeoung
    Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
  • Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
    Jaechan Leem, In-Kyu Lee
    Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
  • Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
    Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress
    Frontiers in Physiology.2016;[Epub]     CrossRef
  • MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
    Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
    PLOS Genetics.2016; 12(10): e1006308.     CrossRef
  • Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
    Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, Jing Wang
    Journal of Biological Chemistry.2016; 291(33): 17405.     CrossRef
  • Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk
    Franziska Koch, Ole Lamp, Mehdi Eslamizad, Joachim Weitzel, Björn Kuhla, Andrew C. Gill
    PLOS ONE.2016; 11(8): e0160912.     CrossRef
  • Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver
    Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland, Brenda K. Richards
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
    Mithilesh Kumar Jha, In-Kyu Lee, Kyoungho Suk
    Neuroscience & Biobehavioral Reviews.2016; 68: 1.     CrossRef
  • 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
    Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar
    Journal of Biological Chemistry.2016; 291(3): 1514.     CrossRef
  • Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
    Sina Oppermann, Avery J. Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, Guizhei Wang, Jarkko Ylanko, Brian Leber, David Andrews, David E. Spaner
    Oncotarget.2016; 7(45): 72608.     CrossRef
  • Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments
    Hiroshi Kido, Irene L. Indalao, Hyejin Kim, Takashi Kimoto, Satoko Sakai, Etsuhisa Takahashi
    Respiratory Investigation.2016; 54(5): 312.     CrossRef
  • Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity
    Tao Gao, Jian Chen, Zhiqi Shi, Yin-Won Lee
    PLOS ONE.2016; 11(6): e0158077.     CrossRef
  • Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
    Michael J. Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F. Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E. Scott, Lubos Bohunek, Jerzy E. Kulpa, S. R. Wayne Chen, David Fedida, Roger W. Brownsey, Christoph H. Borchers, Leonard J. Fo
    Journal of Biological Chemistry.2016; 291(45): 23490.     CrossRef
  • Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
    Nam Ho Jeoung
    Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
  • Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells
    Mariana Regueira, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, María Fernanda Riera
    REPRODUCTION.2015; 150(4): 311.     CrossRef
  • Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes
    Anna Polus, Beata Kiec-Wilk, Urszula Razny, Anna Gielicz, Gerd Schmitz, Aldona Dembinska-Kiec
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2015; 1851(9): 1146.     CrossRef
  • A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
    Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René
    EMBO Molecular Medicine.2015; 7(5): 526.     CrossRef
  • A genetic perspective on rapid evolution in cane toads (Rhinella marina)
    Lee A. Rollins, Mark F. Richardson, Richard Shine
    Molecular Ecology.2015; 24(9): 2264.     CrossRef
  • Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
    Qin Hao, Rachita Yadav, Astrid L. Basse, Sidsel Petersen, Si B. Sonne, Simon Rasmussen, Qianhua Zhu, Zhike Lu, Jun Wang, Karine Audouze, Ramneek Gupta, Lise Madsen, Karsten Kristiansen, Jacob B. Hansen
    American Journal of Physiology-Endocrinology and Metabolism.2015; 308(5): E380.     CrossRef
  • Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
    Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myeong Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A
    Scientific Reports.2015;[Epub]     CrossRef
  • Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
    Laura D. Brown, Paul J. Rozance, Jennifer L. Bruce, Jacob E. Friedman, William W. Hay, Stephanie R. Wesolowski
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R920.     CrossRef
  • The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
    T Joshi, M Johnson, R Newton, M A Giembycz
    British Journal of Pharmacology.2015; 172(10): 2634.     CrossRef
  • The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
    Jianrong Lu, Ming Tan, Qingsong Cai
    Cancer Letters.2015; 356(2): 156.     CrossRef
  • The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
    In-Kyu Lee
    Diabetes & Metabolism Journal.2014; 38(3): 181.     CrossRef
  • Rapid in Vitro Metabolism of the Flame Retardant Triphenyl Phosphate and Effects on Cytotoxicity and mRNA Expression in Chicken Embryonic Hepatocytes
    Guanyong Su, Doug Crump, Robert J. Letcher, Sean W. Kennedy
    Environmental Science & Technology.2014; 48(22): 13511.     CrossRef
  • Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury
    Michael A. Petrie, Manish Suneja, Elizabeth Faidley, Richard K. Shields
    Physiological Reports.2014; 2(2): e00248.     CrossRef
  • Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
    Kazuhiko Yamane, Irene L. Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido, Amy Lynn Adamson
    PLoS ONE.2014; 9(5): e98032.     CrossRef
  • Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal
    Maria Guitart, Óscar Osorio-Conles, Thais Pentinat, Judith Cebrià, Judit García-Villoria, David Sala, David Sebastián, Antonio Zorzano, Antonia Ribes, Josep C. Jiménez-Chillarón, Celia García-Martínez, Anna M. Gómez-Foix, Cedric Moro
    PLoS ONE.2014; 9(5): e98109.     CrossRef
  • CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
    Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2014; 1843(2): 372.     CrossRef
  • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
    Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, Anne C. Ferguson-Smith
    Proceedings of the National Academy of Sciences.2014; 111(45): 16088.     CrossRef
  • The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
    Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
    Nutrition & Metabolism.2014;[Epub]     CrossRef
  • Time‐dependent effects of the flame retardant tris(1,3‐dichloro‐2‐propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds
    Amani Farhat, Doug Crump, Emily Porter, Suzanne Chiu, Robert J. Letcher, Guanyong Su, Sean W. Kennedy
    Environmental Toxicology and Chemistry.2014; 33(12): 2842.     CrossRef
  • Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue
    S Zhang, R P McMillan, M W Hulver, P B Siegel, L H Sumners, W Zhang, M A Cline, E R Gilbert
    International Journal of Obesity.2014; 38(10): 1374.     CrossRef
  • Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
    Yolanda F. Otero, John M. Stafford, Owen P. McGuinness
    Journal of Biological Chemistry.2014; 289(30): 20462.     CrossRef
  • Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells
    Eili Tranheim Kase, Nataša Nikolić, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan, Darcy Johannsen
    PLoS ONE.2013; 8(4): e59972.     CrossRef
  • Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
    Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian
    Diabetes & Metabolism Journal.2013; 37(4): 270.     CrossRef
  • The orphan nuclear receptors in cancer and diabetes
    Harmit S. Ranhotra
    Journal of Receptors and Signal Transduction.2013; 33(4): 207.     CrossRef
  • Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
    Daniel Leclerc, Nancy Lévesque, Yuanhang Cao, Liyuan Deng, Qing Wu, Jasmine Powell, Carmen Sapienza, Rima Rozen
    Cancer Prevention Research.2013; 6(11): 1171.     CrossRef
Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
Nam Ho Jeoung, Robert A. Harris
Korean Diabetes J. 2010;34(5):274-283.   Published online October 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.5.274
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AbstractAbstract PDFPubReader   

In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In the fasted state a relatively low activity of the PDC helps maintain blood glucose levels by conserving pyruvate and other three carbon compounds for gluconeogenesis. The relative activities of the pyruvate dehydrogenase kinases (PDKs) and the opposing pyruvate dehydrogenase phosphatases determine the activity of PDC in the fed and fasted states. Up regulation of PDK4 is largely responsible for inactivation of PDC in the fasted state. PDK4 knockout mice have lower fasting blood glucose levels than wild type mice, proving that up regulation of PDK4 is important for normal glucose homeostasis. In type 2 diabetes, up regulation of PDK4 also inactivates PDC, which promotes gluconeogenesis and thereby contributes to the hyperglycemia characteristic of this disease. When fed a high fat diet, wild type mice develop fasting hyperglycemia but PDK4 knockout mice remain euglycemic, proving that up regulation of PDK4 contributes to hyperglycemia in diabetes. These finding suggest PDK4 inhibitors might prove useful in the treatment of type 2 diabetes.

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  • Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women
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  • The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse
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    Atherosclerosis.2024; : 118599.     CrossRef
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    Chen Bai, Yisi Liu, Yichen Zhao, Qing Ye, Cheng Zhao, Yang Liu, Jiangang Wang
    Journal of Cardiovascular Translational Research.2022; 15(6): 1393.     CrossRef
  • The impact of different feeds on DNA methylation, glycolysis/gluconeogenesis signaling pathway, and gene expression of sheep muscle
    Feng Song, Zaccheaus Pazamilala Akonyani, Ying Li, Deqiqige Su, Lantuya Wu, Yue Pang, Sile Hu, Dubala Wu, Chun Li, Ding Yang, Jianghong Wu
    PeerJ.2022; 10: e13455.     CrossRef
  • Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1‐13C]‐l‐lactate
    Jun Chen, Edward P. Hackett, Zoltan Kovacs, Craig R. Malloy, Jae Mo Park
    Magnetic Resonance in Medicine.2021; 85(3): 1175.     CrossRef
  • Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
    Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
    Journal of Diabetes Investigation.2021; 12(1): 21.     CrossRef
  • Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
    Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Gokhan Zengin, Nicoleta Negrut, Delia Carmen Nistor-Cseppento, Flavia Maria Pavel, Raluca Anca Corb Aron, Simona Bungau
    International Journal of Molecular Sciences.2021; 22(6): 3179.     CrossRef
  • Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
    Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li
    Bioscience Reports.2021;[Epub]     CrossRef
  • PDK2: An Underappreciated Regulator of Liver Metabolism
    Benjamin L. Woolbright, Robert A. Harris
    Livers.2021; 1(2): 82.     CrossRef
  • Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
    Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
    Experimental & Molecular Medicine.2021; 53(9): 1390.     CrossRef
  • Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells
    Ling Jin, Minkyoung Cho, Bo-Sung Kim, Jung Ho Han, Sungmi Park, In-Kyu Lee, Dongryeol Ryu, Jae Ho Kim, Sung-Jin Bae, Ki-Tae Ha
    BMB Reports.2021; 54(11): 563.     CrossRef
  • Aberrant PDK4 Promoter Methylation Preceding Hyperglycemia in a Mouse Model
    Sulistyo Emantoko Dwi Putra, Stephanie Singajaya, Ferensia Thesman, Dicky Andhika Pranoto, Ricky Sanjaya, Yoanes Maria Vianney, Ida Bagus Made Artadana
    Applied Biochemistry and Biotechnology.2020; 190(3): 1023.     CrossRef
  • Plasma Lipid Profile and Cardiac Risk Markers in Diabetic Nephropathy
    Nagendra Subba Rammaiah, Praveenkumar Deverbhavi, Kashinath Rattihalli Thirumala
    Journal of Evolution of Medical and Dental Sciences.2020; 9(8): 516.     CrossRef
  • The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis
    Khalia R. Primer, Peter J. Psaltis, Joanne T.M. Tan, Christina A. Bursill
    International Journal of Molecular Sciences.2020; 21(10): 3633.     CrossRef
  • The lncRNA ENST00000608794 acts as a competing endogenous RNA to regulate PDK4 expression by sponging miR-15b-5p in dexamethasone induced steatosis
    Fengqiong Liu, Qing Chen, Fa Chen, Jing Wang, Ruijie Gong, Baochang He
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(10): 1449.     CrossRef
  • The Changing Landscape of Pharmacotherapy for Diabetes Mellitus: A Review of Cardiovascular Outcomes
    Linda Wu, Jenny E. Gunton
    International Journal of Molecular Sciences.2019; 20(23): 5853.     CrossRef
  • Emerging role of the orphan nuclear receptor estrogen-related receptor gamma in liver metabolic diseases
    Don-Kyu Kim, Hueng-Sik Choi
    Liver Research.2019; 3(2): 99.     CrossRef
  • Characterization of in vitro and in vivo metabolism of leelamine using liquid chromatography-tandem mass spectrometry
    Riya Shrestha, Jung Jae Jo, DooHyun Lee, Taeho Lee, Sangkyu Lee
    Xenobiotica.2019; 49(5): 577.     CrossRef
  • Proteomics of Rat Lungs Infected by Cryptococcus gattii Reveals a Potential Warburg-like Effect
    Rafael L. Rosa, Markus Berger, Lucélia Santi, David Driemeier, Paula Barros Terraciano, Alexandre R. Campos, Jorge A. Guimarães, Marilene H. Vainstein, John R. Yates, Walter O. Beys-da-Silva
    Journal of Proteome Research.2019; 18(11): 3885.     CrossRef
  • Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease
    Waqar Ahmad
    Experimental Brain Research.2018; 236(11): 2857.     CrossRef
  • Peroxisome proliferator-activated receptor β/δ does not regulate glucose uptake and lactose synthesis in bovine mammary epithelial cells cultivated in vitro
    Jayant Lohakare, Johan S Osorio, Massimo Bionaz
    Journal of Dairy Research.2018; 85(3): 295.     CrossRef
  • Protective potential of Averrhoa bilimbi fruits in ameliorating the hepatic key enzymes in streptozotocin-induced diabetic rats
    Surya B Kurup, Mini S
    Biomedicine & Pharmacotherapy.2017; 85: 725.     CrossRef
  • Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
    Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
    Kidney International.2017; 91(4): 880.     CrossRef
  • PDK4 Deficiency Induces Intrinsic Apoptosis in Response to Starvation in Fibroblasts from Doberman Pinschers with Dilated Cardiomyopathy
    Kathryn Taggart, Amara Estrada, Patrick Thompson, Francisco Lourenco, Sara Kirmani, Silveli Suzuki-Hatano, Christina A. Pacak
    BioResearch Open Access.2017; 6(1): 182.     CrossRef
  • High-salt intake negatively regulates fat deposition in mouse
    Huanxian Cui, Shuyan Yang, Maiqing Zheng, Ranran Liu, Guiping Zhao, Jie Wen
    Scientific Reports.2017;[Epub]     CrossRef
  • The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus
    Jasmine Plows, Florence Budin, Rebecka Andersson, Valerie Mills, Katherine Mace, Sandra Davidge, Mark Vickers, Philip Baker, Irma Silva-Zolezzi, Joanna Stanley
    Nutrients.2017; 9(2): 141.     CrossRef
  • Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis
    John A Burns, Huanjia Zhang, Elizabeth Hill, Eunsoo Kim, Ryan Kerney
    eLife.2017;[Epub]     CrossRef
  • Equine performance genes and the future of doping in horseracing
    Tessa Wilkin, Anna Baoutina, Natasha Hamilton
    Drug Testing and Analysis.2017; 9(9): 1456.     CrossRef
  • Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model
    Tao WANG, Hong-Guo SUN, Yong-Li HUA, Peng-Ling LI, Yan-Ming WEI
    Chinese Journal of Natural Medicines.2016; 14(3): 210.     CrossRef
  • MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
    Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
    PLOS Genetics.2016; 12(10): e1006308.     CrossRef
  • Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats
    Subramani Srinivasan, Udaiyar Muruganathan
    Chemico-Biological Interactions.2016; 250: 38.     CrossRef
  • Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
    Hana Park, Nam Ho Jeoung
    Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
  • Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion
    Kripa Raman, Stefanie Aeschbacher, Matthias Bossard, Thomas Hochgruber, Andreas J. Zimmermann, Beat A. Kaufmann, Katrin Pumpol, Peter Rickenbacker, Guillaume Paré, David Conen, Alena Talkachova
    PLOS ONE.2016; 11(6): e0157550.     CrossRef
  • Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver
    Poonamjot Deol, Jane R. Evans, Joseph Dhahbi, Karthikeyani Chellappa, Diana S. Han, Stephen Spindler, Frances M. Sladek, Jonathan Peterson
    PLOS ONE.2015; 10(7): e0132672.     CrossRef
  • Type 2 diabetes mellitus
    Ralph A. DeFronzo, Ele Ferrannini, Leif Groop, Robert R. Henry, William H. Herman, Jens Juul Holst, Frank B. Hu, C. Ronald Kahn, Itamar Raz, Gerald I. Shulman, Donald C. Simonson, Marcia A. Testa, Ram Weiss
    Nature Reviews Disease Primers.2015;[Epub]     CrossRef
  • Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
    Nam Ho Jeoung
    Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
  • Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: Functions of glucose and lipid metabolism in the feed intake of chickens
    Xin-Ling Fang, Xiao-Tong Zhu, Sheng-Feng Chen, Zhi-Qi Zhang, Qing-Jie Zeng, Lin Deng, Jian-Long Peng, Jian-Jian Yu, Li-Na Wang, Song-Bo Wang, Ping Gao, Qing-Yan Jiang, Gang Shu
    Poultry Science.2014; 93(11): 2841.     CrossRef
  • The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
    Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
    Nutrition & Metabolism.2014;[Epub]     CrossRef
  • Proteome-Based Systems Biology Analysis of the Diabetic Mouse Aorta Reveals Major Changes in Fatty Acid Biosynthesis as Potential Hallmark in Diabetes Mellitus–Associated Vascular Disease
    Holger Husi, Tom Van Agtmael, William Mullen, Ferdinand H. Bahlmann, Joost P. Schanstra, Antonia Vlahou, Christian Delles, Paul Perco, Harald Mischak
    Circulation: Cardiovascular Genetics.2014; 7(2): 161.     CrossRef
  • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice
    Sasmita Tripathy, Kelli A. Lytle, Robert D. Stevens, James R. Bain, Christopher B. Newgard, Andrew S. Greenberg, Li-Shin Huang, Donald B. Jump
    Journal of Lipid Research.2014; 55(7): 1448.     CrossRef
  • Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum
    Elaine M. Richards, Charles E. Wood, Maria Belen Rabaglino, Andrew Antolic, Maureen Keller-Wood
    Physiological Genomics.2014; 46(15): 547.     CrossRef
  • Novel Agents for the Treatment of Type 2 Diabetes
    Ralph A. DeFronzo, Curtis L. Triplitt, Muhammad Abdul-Ghani, Eugenio Cersosimo
    Diabetes Spectrum.2014; 27(2): 100.     CrossRef
  • Serotonin (5-HT) Affects Expression of Liver Metabolic Enzymes and Mammary Gland Glucose Transporters during the Transition from Pregnancy to Lactation
    Jimena Laporta, Tonia L. Peters, Kathryn E. Merriman, Chad M. Vezina, Laura L. Hernandez, Julie A. Chowen
    PLoS ONE.2013; 8(2): e57847.     CrossRef
  • Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats
    Deon B. Williams, Zhongxiao Wan, Bruce C. Frier, Rhonda C. Bell, Catherine J. Field, David C. Wright
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2012; 302(1): R49.     CrossRef
  • Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome
    Seong-Su Moon, Jung-Eun Lee, Young-Sil Lee, Su-Won Kim, Nam Ho Jeoung, In-Kyu Lee, Jung-Guk Kim
    Diabetes Research and Clinical Practice.2012; 95(2): 230.     CrossRef
  • Sex-dependent differences in rat hepatic lipid accumulation and insulin sensitivity in response to diet-induced obesity
    Antònia Nadal-Casellas, Ana Maria Proenza, Isabel Lladó, Magdalena Gianotti
    Biochemistry and Cell Biology.2012; 90(2): 164.     CrossRef
  • Prednisolone-Induced Changes in Gene-Expression Profiles in Healthy Volunteers
    Erik JM Toonen, Wilco WM Fleuren, Ulla Nässander, Marie-José C van Lierop, Susanne Bauerschmidt, Wim HA Dokter, Wynand Alkema
    Pharmacogenomics.2011; 12(7): 985.     CrossRef

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