Diabetes & Metabolism Journal

Review

Basic Research
Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?: Kerstin Rohde, Imke Schamarek, Matthias Blüher; Diabetes Metab J. 2020;44(4):509-528. Published online May 11, 2020; DOI: https://doi.org/10.4093/dmj.2020.0058

11,437 View
284 Download
35 Web of Science
35 Crossref

Premature obesity-related mortality is caused by cardiovascular and pulmonary diseases, type 2 diabetes mellitus, physical disabilities, osteoarthritis, and certain types of cancer. Obesity is caused by a positive energy balance due to hyper-caloric nutrition, low physical activity, and energy expenditure. Overeating is partially driven by impaired homeostatic feedback of the peripheral energy status in obesity. However, food with its different qualities is a key driver for the reward driven hedonic feeding with tremendous consequences on calorie consumption. In addition to visual and olfactory cues, taste buds of the oral cavity process the earliest signals which affect the regulation of food intake, appetite and satiety. Therefore, taste buds may play a crucial role how food related signals are transmitted to the brain, particularly in priming the body for digestion during the cephalic phase. Indeed, obesity development is associated with a significant reduction in taste buds. Impaired taste bud sensitivity may play a causal role in the pathophysiology of obesity in children and adolescents. In addition, genetic variation in taste receptors has been linked to body weight regulation. This review discusses the importance of taste buds as contributing factors in the development of obesity and how obesity may affect the sense of taste, alterations in food preferences and eating behavior.

Citations

Citations to this article as recorded by

Chronic social defeat stress broadly inhibits gene expression in the peripheral taste system and alters taste responses in mice
Katelyn Tu, Mary Zhou, Jidong J. Tan, Loza Markos, Cameron Cloud, Minliang Zhou, Naoki Hayashi, Nancy E. Rawson, Robert F. Margolskee, Hong Wang
Physiology & Behavior.2024; 275: 114446. CrossRef
Commentary: Is obesity associated with taste alterations? a systematic review
Marco Alessandrini, Alessandra Vezzoli, Simona Mrakic-Sposta, Sandro Malacrida, Alessandro Micarelli
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Obese Taste Bud study: Objectives and study design
Alexander Kersten, Andrea Lorenz, Cita Nottmeier, Michael Schmidt, Anuschka Roesner, Florian Christoph Richter, Kristin Röhrborn, A. Veronica Witte, Sebastian Hahnel, Till Koehne, Matthias Blüher, Michael Stumvoll, Kerstin Rohde‐Zimmermann, Imke Schamarek
Diabetes, Obesity and Metabolism.2024;[Epub] CrossRef
Testing reward processing models of obesity using in-the-moment assessments of subjective enjoyment of food and non-food activities
Christina Chwyl, Erica M. LaFata, Sophie R. Abber, Adrienne S. Juarascio, Evan M. Forman
Eating Behaviors.2023; 48: 101698. CrossRef
Taste Function in Adult Humans from Lean Condition to Stage II Obesity: Interactions with Biochemical Regulators, Dietary Habits, and Clinical Aspects
Alessandro Micarelli, Alessandra Vezzoli, Sandro Malacrida, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Ilaria Iennaco, Sara Caputo, Simona Mrakic-Sposta, Marco Alessandrini
Nutrients.2023; 15(5): 1114. CrossRef
Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models
Diana Sousa, Mariana Rocha, Andreia Amaro, Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Tamaeh Monteiro-Alfredo, Cátia Barra, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, José Magalhães, Armando Caseiro, Paulo Cezar de Freitas M
Nutrients.2023; 15(5): 1281. CrossRef
Exercise modifies fatty acid perception and metabolism
Deepankumar Shanmugamprema, Karthi Muthuswamy, Vinithra Ponnusamy, Gowtham Subramanian, Keerthana Vasanthakumar, Vasanth Krishnan, Selvakumar Subramaniam
Acta Physiologica.2023;[Epub] CrossRef
The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception
Imke Schamarek, Lars Anders, Rima M. Chakaroun, Peter Kovacs, Kerstin Rohde-Zimmermann
Nutrition Journal.2023;[Epub] CrossRef
Smell, taste and food habits changes along body mass index increase: an observational study
Alessandro Micarelli, Sandro Malacrida, Alessandra Vezzoli, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Sara Caputo, Simona Mrakic-Sposta, Marco Alessandrini
European Archives of Oto-Rhino-Laryngology.2023; 280(12): 5595. CrossRef
Sweet-inhibiting effects of gurmarin on intake during repeated acute and long-term sugar exposure: A behavioural analysis using an animal model
Raquel Rayo-Morales, Antonio Segura-Carretero, Nicolas Poirier, Loïc Briand, David Garcia-Burgos
Journal of Functional Foods.2023; 108: 105743. CrossRef
Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans
Raquel Rayo-Morales, Antonio Segura-Carretero, Isabel Borras-Linares, David Garcia-Burgos
Heliyon.2023; 9(10): e19733. CrossRef
The oral microbial odyssey influencing chronic metabolic disease
Upasana Gupta, Priyankar Dey
Archives of Physiology and Biochemistry.2023; : 1. CrossRef
Taste of Fat and Obesity: Different Hypotheses and Our Point of View
Laurent Brondel, Didier Quilliot, Thomas Mouillot, Naim Akhtar Khan, Philip Bastable, Vincent Boggio, Corinne Leloup, Luc Pénicaud
Nutrients.2022; 14(3): 555. CrossRef
Effect of Obesity Surgery on Taste
Alhanouf S. Al-Alsheikh, Shahd Alabdulkader, Brett Johnson, Anthony P. Goldstone, Alexander Dimitri Miras
Nutrients.2022; 14(4): 866. CrossRef
Oral motor function in obesity
Mariana Cristina Zanin Castro, Carla Manfredi dos Santos, Raquel Eduardo Lucas, Claudia Maria de Felício, Roberto Oliveira Dantas
Journal of Oral Rehabilitation.2022; 49(5): 529. CrossRef
The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review
Klara Wilk, Wiktoria Korytek, Marta Pelczyńska, Małgorzata Moszak, Paweł Bogdański
Nutrients.2022; 14(6): 1261. CrossRef
Effects of visual and aromatic stimulations on the perception of five fundamental tastes
Mayu Itoh, Aya Kitagawa, Harumi Ouchi, Mana Yamaguchi, Ran Watanabe, Hideyuki Sone, Shin Kamiyama
Bioscience, Biotechnology, and Biochemistry.2022; 86(5): 655. CrossRef
Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET
Kristine Eidal Tanem, Einar Stensvold, Petter Wilberg, Anne B. Skaare, Preet Bano Singh, Petter Brandal, Bente Brokstad Herlofson
Supportive Care in Cancer.2022; 30(7): 6155. CrossRef
Changes in Food Choice, Taste, Desire, and Enjoyment 1 Year after Sleeve Gastrectomy: A Prospective Study
Luigi Schiavo, Silvana Mirella Aliberti, Pietro Calabrese, Anna Maria Senatore, Lucia Severino, Gerardo Sarno, Antonio Iannelli, Vincenzo Pilone
Nutrients.2022; 14(10): 2060. CrossRef
Characterizing Adolescents' Dietary Intake by Taste: Results From the UK National Diet and Nutrition Survey
Areej Bawajeeh, Michael A. Zulyniak, Charlotte E. L. Evans, Janet E. Cade
Frontiers in Nutrition.2022;[Epub] CrossRef
Sleeve Gastrectomy-Induced Body Mass Index Reduction Increases the Intensity of Taste Perception’s and Reduces Bitter-Induced Pleasantness in Severe Obesity
Sara Rurgo, Elena Cantone, Marcella Pesce, Eleonora Efficie, Mario Musella, Barbara Polese, Barbara De Conno, Marta Pagliaro, Luisa Seguella, Bruna Guida, Giuseppe Esposito, Giovanni Sarnelli
Journal of Clinical Medicine.2022; 11(14): 3957. CrossRef
Genetic variation in sweet taste receptors and a mechanistic perspective on sweet and fat taste sensation in the context of obesity
Vinithra Ponnusamy, Gowtham Subramanian, Karthi Muthuswamy, Deepankumar Shanmugamprema, Vasanth Krishnan, Thirunavukkarasu Velusamy, Selvakumar Subramaniam
Obesity Reviews.2022;[Epub] CrossRef
Applying a systems perspective to understand the mechanisms of the European School Fruit and Vegetable Scheme
Mahshid Zolfaghari, Biljana Meshkovska, Anna Banik, Carlijn B M Kamphuis, Birgit Kopainsky, Aleksandra Luszczynska, Celine Murrin, Nanna Lien
European Journal of Public Health.2022; 32(Supplement): iv107. CrossRef
Self-Reported Sensory Decline in Older Adults Is Longitudinally Associated With Both Modality-General and Modality-Specific Factors
Alan O’ Dowd, Rebecca J Hirst, Annalisa Setti, Rose Anne Kenny, Fiona N Newell, Nancy W Glynn
Innovation in Aging.2022;[Epub] CrossRef
The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel: sugar sensing for the regulation of energy homeostasis
Ryusuke Yoshida, Keiko Yasumatsu, Yuzo Ninomiya
Current Opinion in Physiology.2021; 20: 57. CrossRef
Gustatory Function Can Improve after Multimodal Lifestyle Intervention: A Longitudinal Observational Study in Pediatric Patients with Obesity
Laura Kalveram, Jacob Gohlisch, Jana Brauchmann, Johanna Overberg, Peter Kühnen, Susanna Wiegand
Childhood Obesity.2021; 17(2): 136. CrossRef
Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults
Muthuswamy Karthi, Shanmugamprema Deepankumar, Ponnusamy Vinithra, Subramanian Gowtham, Krishnan Vasanth, Palanivelu Praveen Raj, Rajasekaran Senthilkumar, Subramaniam Selvakumar
Clinical Nutrition.2021; 40(5): 2707. CrossRef
Lezzet Algısının Oluşmasında Çevresel ve Genetik Faktörlerin Etkileri
Mücahit MUSLU, Gülden Fatma GÖKÇAY
Batı Karadeniz Tıp Dergisi.2021; 5(1): 7. CrossRef
Food Preferences and Obesity
Sara Spinelli, Erminio Monteleone
Endocrinology and Metabolism.2021; 36(2): 209. CrossRef
Western Diet Induced Remodelling of the Tongue Proteome
Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K. Montgomery, Matthew J. Watt, Benjamin L. Parker
Proteomes.2021; 9(2): 22. CrossRef
Obesity-induced taste dysfunction, and its implications for dietary intake
Fiona Harnischfeger, Robin Dando
International Journal of Obesity.2021; 45(8): 1644. CrossRef
Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020
Jea Hwa Jang, Obin Kwon, Seok Jun Moon, Yong Taek Jeong
Endocrinology and Metabolism.2021; 36(3): 469. CrossRef
Smash of diabetes mellitus on smile
Farhana Akter, Mainul Haque
Advances in Human Biology.2021; 11(3): 273. CrossRef
Perception des acides gras et potentiels évoqués gustatifs : application dans l’obésité
Thomas Mouillot, Laurent Brondel, Agnès Jacquin-Piques
Cahiers de Nutrition et de Diététique.2021; 56(5): 280. CrossRef
Trastornos del gusto como indicador de enfermedad sistémica
Karla Ivohnne Pedraza Maquera, Caroll Johana Uberlinda Lévano Villanueva
Revista Odontológica Basadrina.2021; 5(2): 52. CrossRef

Original Articles

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus: Bo Kyung Koo, Jung Hun Ohn, Soo-Heon Kwak, Min Kyong Moon; Diabetes Metab J. 2014;38(4):285-293. Published online August 20, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.4.285

3,868 View
40 Download
5 Web of Science
4 Crossref

Abstract PDF PubReader

Background

The current perception threshold (CPT) could be quantified by stimulating Aβ and C fibers at 2,000 and 5 Hz, respectively. C fibers play a role in the autonomic nervous system and are involved in temperature and pain sensation. We evaluated the usefulness of CPT for diagnosing distal polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) in diabetic patients.

Methods

The CPT was measured in the index finger (C7 level) and in the third toe (L5 level) in diabetic patients aged 30 to 69 years. We assessed DPN according to the neuropathy total symptom score-6 (NTSS-6) and 10-g monofilament pressure sensation. Subjects with a NTSS-6 >6 or with abnormal 10-g monofilament sensation were defined to have DPN. CAN was evaluated by spectral analysis of heart rate variability and by Ewing's traditional tests.

Results

The subjects with DPN had significantly higher CPT at all of the frequencies than the subjects without DPN (P<0.05). Abnormal 10-g monofilament sensation and NTSS-6 >6 could be most precisely predicted by CPT at 2,000 and 5 Hz, respectively. However, only 6.5% and 19.6% of subjects with DPN had an abnormal CPT at 2,000 Hz at the C7 and L5 levels. Although CPT at 5 Hz showed a negative correlation with the power of low and high frequency in the spectral analysis (P<0.05), only 16.7% of subjects with CAN exhibited an abnormal CPT at the same frequency.

Conclusion

Although the CPT is significantly associated with neuropathic symptoms or signs corresponding to the nerve fiber stimulated, it provides little additional information compared with conventional evaluations.

Citations

Citations to this article as recorded by

New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine
Heng Yang, Gordon Sloan, Yingchun Ye, Shuo Wang, Bihan Duan, Solomon Tesfaye, Ling Gao
Frontiers in Endocrinology.2020;[Epub] CrossRef
Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold
Joong Hyun Park, Jong Chul Won
Diabetes & Metabolism Journal.2018; 42(6): 519. CrossRef
Association between Pain Sensitivity, Central Sensitization, and Functional Disability in Adolescents With Joint Hypermobility
Elizabeth A. Bettini, Ki Moore, Yunfei Wang, Pamela S. Hinds, Julia C. Finkel
Journal of Pediatric Nursing.2018; 42: 34. CrossRef
The impact of neuropathic pain and other comorbidities on the quality of life in patients with diabetes
Vesna Dermanovic Dobrota, Pero Hrabac, Dinko Skegro, Ranko Smiljanic, Savko Dobrota, Ingrid Prkacin, Neva Brkljacic, Kristijan Peros, Martina Tomic, Vesna Lukinovic-Skudar, Vanja Basic Kes
Health and Quality of Life Outcomes.2014;[Epub] CrossRef

Perception of Clinicians and Diabetic Patients on the Importance of Postprandial Glucose Control and Diabetes Education Status: A Cross Sectional Survey: Ji Hun Choi, Cheol Young Park, Bong Soo Cha, In Joo Kim, Tae Sun Park, Joong Yeol Park, Kyung Soo Park, Kun Ho Yoon, In Kyu Lee, Sung Woo Park; Diabetes Metab J. 2012;36(2):120-127. Published online April 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.2.120

3,866 View
33 Download
5 Crossref

Abstract PDF PubReader

Background

Recent studies have shown the importance of postprandial glucose (PPG) in the development of diabetes complications. This study was conducted in order to survey the perceptions of clinicians and diabetic patients with respect to PPG management and the current status of diabetes education.

Methods

This was a cross-sectional study involving face-to-face interviews and an open questionnaire survey conducted in Korea. A total of 300 patients and 130 clinicians completed questionnaires, which included current education status, self monitoring of blood glucose (SMBG), criteria of diagnosis and management, and perceptions relating to PPG management.

Results

While there was a significantly higher perceived need for diabetes education, the sufficiency of the current education was considered to be severely lacking. Fasting plasma glucose (FPG), PPG, and glycosylated hemoglobin (HbA1c) were all important considerations for clinicians when making a diagnosis of diabetes, although PPG was considered less important than FPG or HbA1c in the treatment of diabetes. Most clinicians and patients were aware of the importance of PPG, but actual education on the importance of PPG was not actively being delivered.

Conclusion

Our study showed that the current status of diabetes education is insufficient to meet the needs of the Korean population. A considerable gap was found to exist between awareness and what was actually taught in the current education program in regard to the importance of PPG. These results suggest that clinicians need to be more active in patient education, especially in regard to the importance of PPG.

Citations

Citations to this article as recorded by

Addressing Overbasalization to Achieve Glycemic Targets
Kevin Cowart, Rachel Franks, Olivia Pane, Ellen Murphy, Kelly Oldziej
ADCES in Practice.2022; 10(2): 30. CrossRef
Post hoc efficacy and safety analysis of insulin glargine/lixisenatide fixed- ratio combination in North American patients compared with the rest of world
George Dailey, Harpreet S Bajaj, Terry Dex, Melanie Groleau, William Stager, Aaron Vinik
BMJ Open Diabetes Research & Care.2019; 7(1): e000581. CrossRef
Experiences of Diabetes Education among Educators of Diabetes : a content analysis approach
Soo Jin Kang, Soo Jung Chang
Journal of Korean Public Health Nursing.2016; 30(2): 221. CrossRef
Does Availability of Reliable Home Blood Glucose Data at Diabetes Appointments Improve Glycemia?
Gillian S. Boyd-Woschinko, David L. Kaiser, Michael Diefenbach, Ronald Tamler
Endocrine Practice.2014; 20(4): 299. CrossRef
Safety and effectiveness of insulin aspart in type 2 diabetic patients: Results from the ASEAN cohort of the A1chieve study
Wan Mohamad Wan Bebakar, Mary Anne Lim-Abrahan, Ananá B. Jain, Darren Seah, Pradana Soewondo
Diabetes Research and Clinical Practice.2013; 100: S17. CrossRef

The Effects of Alpha-Lipoic Acid on Epidermal Nerve Preservation in the Diabetic Neuropathy of OLETF Rats.: Ming Han Piao, Ji Hyun Park, Hong Sun Baek, Tae Sun Park; Korean Diabetes J. 2006;30(3):170-176. Published online May 1, 2006; DOI: https://doi.org/10.4093/jkda.2006.30.3.170

1,731 View
16 Download

Abstract PDF: BACKGROUND
Alpha-Lipoic acid (ALA) administration has been reported to ameliorate some of symptoms of peripheral polyneuropathy in diabetic patients and to improve endoneurial nutritive neural blood flow and nerve conduction velocity in diabetic rats. But it is not clear whether ALA has the preservation effect on epidermal nerve fibers (ENFs) density. METHODS: We tested the efficacy of ALA in preserving current perception thresholds (CPTs) and ENFs (numbers/mm) in OLETF (Otsuka Long-Evans Tokushima Fatty) rats, an animal model of type 2 diabetes, which were fed with sucrose until diabetes mellitus developed. Thereafter, one group of OLETF rats was fed with ALA and the other was not for 40 weeks. Diabetic rats were administered with ALA (80 mg/kg of body weight/day) by oral feeding for 40 weeks. The effect of ALA treatment on ENFs preservation was assessed by protein gene product 9.5 immunostaining. Quantification of neuropathic symptoms on the dorsum of hind paws of rat was measured by CPT test every 4 weeks. RESULTS: Numbers of ENF significantly decreased in OLETF rats fed without ALA compared with OLETF rats fed with ALA (P < 0.01). The thresholds at 2000, 250 and 5 Hz in OLETF rats fed with ALA did not increased and OLETF rats without ALA significantly increased at 80 weeks (P < 0.01). CONCLUSION: These observations suggest that administrations of ALA may be useful for preserving ENFs and CPTs in OLETF rats dorsum of hind paws skin.

The Relationship between Salt Perception and Salt Intake in Diabetic patients.: Kye Young Huh, Il Suh, Kyung Rae Kim, Chung Mo Nam, Kyung Won Oh; Korean Diabetes J. 1998;22(1):74-83. Published online January 1, 2001

912 View
19 Download

Abstract PDF: BACKGROUND
The increase of the prevalence rate of diabetes mellitus(DM) and its complications have become a public health problem in Korea. Especially, diabetic macrovascular disease and nephrosis preliminarily require the hypertension treatment which consists of reducing salt intake. Although the salt intake of diabetic patients is so important, there have not been sufficient studies on salt perception and salt intake of diabetic patients in Korea. The purpose of this study was to investigate the relationship between salt perception and salt intake in diabetic patients. METHODS: The materials used in this study were questionnaires, anthropometric measurement, laboratory data and medical charts. Eighty-seven diabetic patients were interviewed at the out-patient department of internal medicine in Yonsei Medical Center Youngdong Severance Hospital. RESULTS: Of these patients, salt intake which was estimated through 24-hour urinary sodium excretion was 16.6gm in men, 12.9gm in women. To the question, 'How much salt do you intake compared to common people?' 38% both men and women answered less. And to the question, Do you think that you should reduce your salt intake?' 55% of men and 33% of women answered 'No. To the question, Do you exert yourself to reduce your salt intake?, 66% of men and 68% of women answered 'Yes. And to the question, Can you reduce your salt intake?, 84% of men and 71% of women answered, Yes. And the major reason of being unable to reduce the salt intake was loss of taste. The relation of 24-hour urinary sodium excretion and duration of DM, the degree of DM control, and the practice of diabetic diet therapy were not significant. CONCLUSION: No significant correlation was found between salt perception and salt intake. Their willingness for the reduction of salt intake were not put into practice in rea1 situation. As a follow-up measure, the medical staff is required to continuously monitor and give feedback to correct the amount of salt intake of diabetic patients. Furthermore, it can be strongly suggested that salt intake reduction program with low salt recipes should be developed and implemented far diabetic patients. This, in conjuction with other therapies such as medical monitoring, will eventually achieve the reduction of salt intake in diabetic patients.

First
Prev
Page of 1
Next
Last

Search