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Probiotics as Complementary Treatment for Metabolic Disorders
Mélanie Le Barz, Fernando F. Anhê, Thibaut V. Varin, Yves Desjardins, Emile Levy, Denis Roy, Maria C. Urdaci, André Marette
Diabetes Metab J. 2015;39(4):291-303.   Published online August 17, 2015
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AbstractAbstract PDFPubReader   

Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic diet can drastically alter bacterial populations (i.e., dysbiosis) leading to activation of pro-inflammatory mechanisms and metabolic endotoxemia, therefore promoting insulin resistance and cardiometabolic disorders. To counteract these deleterious effects, probiotic strains have been developed with the aim of reshaping the microbiome to improve gut health. In this review, we focus on benefits of widely used probiotics describing their potential mechanisms of action, especially their ability to decrease metabolic endotoxemia by restoring the disrupted intestinal mucosal barrier. We also discuss the perspective of using new bacterial strains such as butyrate-producing bacteria and the mucolytic Akkermansia muciniphila, as well as the use of prebiotics to enhance the functionality of probiotics. Finally, this review introduces the notion of genetically engineered bacterial strains specifically developed to deliver anti-inflammatory molecules to the gut.


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  • Akkermansia muciniphila and Alcohol‐Related Liver Diseases. A Systematic Review
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    Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
  • Next generation probiotics: Engineering live biotherapeutics
    Sanjeeva Kumar Murali, Thomas J. Mansell
    Biotechnology Advances.2024; 72: 108336.     CrossRef
  • metaProbiotics: a tool for mining probiotic from metagenomic binning data based on a language model
    Shufang Wu, Tao Feng, Waijiao Tang, Cancan Qi, Jie Gao, Xiaolong He, Jiaxuan Wang, Hongwei Zhou, Zhencheng Fang
    Briefings in Bioinformatics.2024;[Epub]     CrossRef
  • Dietary supplementation of Lactobacillus brevis SAD ameliorates high-fat diet-induced hyperglycemia and associated metabolic issues in Swiss albino mice
    Amlan Jyoti Ghosh, Supriyo Ghosh, Rejuan Islam, Sagar Sarkar, Tilak Saha
    Egyptian Journal of Basic and Applied Sciences.2024; 11(1): 148.     CrossRef
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    Evan Forth, Benjamin Buehner, Ana Storer, Cassandra Sgarbossa, Roumen Milev, Arthi Chinna Meyyappan
    Frontiers in Behavioral Neuroscience.2023;[Epub]     CrossRef
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    Marwa Al-Moghazy, Doha H. Abou baker, Hoda S. El-Sayed
    Biocatalysis and Agricultural Biotechnology.2023; 49: 102664.     CrossRef
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    Miriam Cabello-Olmo, María Oneca, Raquel Urtasun, María J. Pajares, Saioa Goñi, José I. Riezu-Boj, Fermín I. Milagro, Josune Ayo, Ignacio J. Encio, Miguel Barajas, Miriam Araña
    Pharmaceutics.2023; 15(4): 1203.     CrossRef
  • Anti-Inflammatory, Antioxidant, Metabolic and Gut Microbiota Modulation Activities of Probiotic in Cardiac Remodeling Condition: Evidence from Systematic Study and Meta-Analysis of Randomized Controlled Trials
    Nurpudji Astuti Taslim, Muhammad Yusuf, Ade Meidian Ambari, Imke Maria Del Rosario Puling, Filzatuz Zahro Ibrahim, Hardinsyah Hardinsyah, Rudy Kurniawan, William Ben Gunawan, Nelly Mayulu, Victor F. F. Joseph, Nindy Sabrina, Mochammad Rizal, Trina Ekawati
    Probiotics and Antimicrobial Proteins.2023; 15(4): 1049.     CrossRef
  • Probiotics and Health: A Review
    Priti Tomar, Shikha Sharma, Neha Dangi
    Current Probiotics.2023;[Epub]     CrossRef
  • SCD Probiotics mitigate cafeteria diet‐induced liver damage in Wistar rats during development
    Taha Ceylani, Harun Önlü, Seda Keskin, Hüseyin Allahverdi, Hikmet Taner Teker
    Journal of Gastroenterology and Hepatology.2023; 38(12): 2142.     CrossRef
  • Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability
    Yongbo Kang, Xing Kang, Hao Yang, Haixia Liu, Xiaodan Yang, Qingqing Liu, Haixia Tian, Yang Xue, Peng Ren, Xiaoyu Kuang, Yue Cai, Mingwei Tong, Lin Li, Weiping Fan
    Pharmacological Research.2022; 175: 106020.     CrossRef
  • Role of probiotics and prebiotics in mitigation of different diseases
    Sabeena Manzoor, Shoib Mohmad Wani, Sajad Ahmad Mir, Danish Rizwan
    Nutrition.2022; 96: 111602.     CrossRef
  • Balancing reactive oxygen species generation by rebooting gut microbiota
    Vandna Singh, Shruti Ahlawat, Hari Mohan, Sarvajeet Singh Gill, Krishna Kant Sharma
    Journal of Applied Microbiology.2022; 132(6): 4112.     CrossRef
  • Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation
    Mohamed Mokrani, Kamel Charradi, Ferid Limam, Ezzedine Aouani, Maria C. Urdaci
    Gut Pathogens.2022;[Epub]     CrossRef
  • Anticandidal and Antibiofilm Effect of Synbiotics including Probiotics and Inulin-Type Fructans
    Ricardo García-Gamboa, Miguel Domínguez-Simi, Misael S. Gradilla-Hernández, Jorge Bravo, Andrés Moya, Blanca Ruiz-Álvarez, Marisela González-Avila
    Antibiotics.2022; 11(8): 1135.     CrossRef
  • The Biotics Family: Current Knowledge and Future Perspectives in Metabolic Diseases
    Codrina-Madalina Palade, Georgiana-Anca Vulpoi, Radu-Alexandru Vulpoi, Vasile Liviu Drug, Oana-Bogdana Barboi, Manuela Ciocoiu
    Life.2022; 12(8): 1263.     CrossRef
  • The role of probiotic supplementation on insulin resistance in obesity associated diabetes: A mini review
    Seeme Saha, S M Niazur Rahman, Nazmun Nahar Alam
    Biomedicine.2022; 42(4): 651.     CrossRef
  • In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation
    Dalia Elebeedy, Aml Ghanem, Asmaa Saleh, Mona H. Ibrahim, Omkulthom Al Kamaly, Mohammed A. S. Abourehab, Mohamed A. Ali, Ahmed I. Abd El Maksoud, Mahmoud A. El Hassab, Wagdy M. Eldehna
    International Journal of Molecular Sciences.2022; 23(20): 12200.     CrossRef
  • Machine learning for data integration in human gut microbiome
    Peishun Li, Hao Luo, Boyang Ji, Jens Nielsen
    Microbial Cell Factories.2022;[Epub]     CrossRef
  • Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical Study
    Jalal Moludi, Somaieh Saiedi, Behzad Ebrahimi, Mohammad Alizadeh, Yaser Khajebishak, Sevda Saleh Ghadimi
    Journal of Cardiovascular Translational Research.2021; 14(2): 299.     CrossRef
  • Draft genome sequence of Lactobacillus plantarum strain DMR17 isolated from homemade cow dahi of Sikkim Himalayan region: an evaluation of lactate fermentation and secondary metabolism
    Ranjan Kaushal Tirwa, Ishfaq Nabi Najar, Nagendra Thakur, Lalit Kumar Chaurasia, Buddhiman Tamang
    Archives of Microbiology.2021; 203(1): 305.     CrossRef
  • Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
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    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Probiotics ameliorate chronic low-grade inflammation and fat accumulation with gut microbiota composition change in diet-induced obese mice models
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    Applied Microbiology and Biotechnology.2021; 105(3): 1203.     CrossRef
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  • A Brief Overview on Probiotics: The Health Friendly Microbes
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  • Probiotic-directed modulation of gut microbiota is basal microbiome dependent
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    Gut Microbes.2020; 12(1): 1736974.     CrossRef
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  • Light at night affects gut microbial community and negatively impacts host physiology in diurnal animals: Evidence from captive zebra finches
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    Microbiological Research.2020; 241: 126597.     CrossRef
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    Microorganisms.2020; 8(6): 816.     CrossRef
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  • Gut Microbiota Alteration After Long-Term Consumption of Probiotics in the Elderly
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    PeerJ.2019; 7: e6651.     CrossRef
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    Applied Physiology, Nutrition, and Metabolism.2019; 44(7): 765.     CrossRef
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    Microorganisms.2019; 7(10): 456.     CrossRef
  • Current Understanding of the Gut Microflora in Subjects with Nutrition-Associated Metabolic Disorder Such as Obesity and/or Diabetes: Is There Any Relevance with Oral Microflora?
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  • Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota
    Mohd Baasir Gaisawat, Chad W. MacPherson, Julien Tremblay, Amanda Piano, Michèle M. Iskandar, Thomas A. Tompkins, Stan Kubow
    Microorganisms.2019; 8(1): 60.     CrossRef
  • Benefaction of probiotics for human health: A review
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    Nutrients.2018; 10(6): 773.     CrossRef
  • Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications
    Josef R. Bober, Chase L. Beisel, Nikhil U. Nair
    Annual Review of Biomedical Engineering.2018; 20(1): 277.     CrossRef
  • The journey of gut microbiome – An introduction and its influence on metabolic disorders
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  • Immunomodulatory Effects of Probiotics on Cytokine Profiles
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    Probiotics and Antimicrobial Proteins.2018; 10(1): 22.     CrossRef
  • Microbiota intestinal, sobrepeso y obesidad
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  • Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals
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    Food & Function.2017; 8(1): 250.     CrossRef
  • Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition
    Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami, Giuditta Perozzi
    Genes & Nutrition.2017;[Epub]     CrossRef
  • Heat-killed Bifidobacterium animalis subsp. Lactis CECT 8145 increases lean mass and ameliorates metabolic syndrome in cafeteria-fed obese rats
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    Journal of Functional Foods.2017; 38: 251.     CrossRef
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    Frontiers in Pharmacology.2017;[Epub]     CrossRef
  • Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial
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    Journal of Translational Medicine.2017;[Epub]     CrossRef
  • Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus–Positive Patients: Preliminary Results of a New Study Approach
    Giuseppe Corano Scheri, Saeid Najafi Fard, Ivan Schietroma, Andrea Mastrangelo, Claudia Pinacchio, Noemi Giustini, Sara Serafino, Gabriella De Girolamo, Eugenio Nelson Cavallari, Maura Statzu, Luca Laghi, Annamaria Vullo, Giancarlo Ceccarelli, Vincenzo Vu
    International Journal of Tryptophan Research.2017; 10: 117864691771066.     CrossRef
  • Dairy probiotics: Beyond the role of promoting gut and immune health
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    International Dairy Journal.2017; 67: 46.     CrossRef
  • Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification
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    Physiological Genomics.2017; 49(8): 385.     CrossRef
  • Pterostilbene‐induced changes in gut microbiota composition in relation to obesity
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    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Microbiota manipulation for weight change
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    Microbial Pathogenesis.2017; 106: 146.     CrossRef
  • Targeting the gastrointestinal tract to treat type 2 diabetes
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  • Novel perspectives on therapeutic modulation of the gut microbiota
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  • Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials
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  • Gut Microbiota and Obesity
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  • The antioxidative effects of three lactobacilli on high-fat diet induced obese mice
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    RSC Advances.2016; 6(70): 65808.     CrossRef
  • Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity
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    FEBS Open Bio.2016; 6(1): 64.     CrossRef
  • Gnotobiotic mouse model’s contribution to understanding host–pathogen interactions
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    Cellular and Molecular Life Sciences.2016; 73(20): 3961.     CrossRef
  • Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men
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    Basic and Clinical Andrology.2016;[Epub]     CrossRef
  • A typical day working in a laboratory in 2050: are microbiologists becoming chemists and serene workers?
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  • Nutritional advice for community patients: insights from a panel discussion
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    British Journal of Community Nursing.2016; 21(3): 130.     CrossRef
Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity
Cesar Corzo, Patrick R. Griffin
Diabetes Metab J. 2013;37(6):395-403.   Published online December 12, 2013
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AbstractAbstract PDFPubReader   

Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.


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    Diabetes, Obesity and Metabolism.2023; 25(S3): 3.     CrossRef
  • The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics
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    Frontiers in Genetics.2022;[Epub]     CrossRef
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    P. Nakandakare, C. F. Nicoletti, N. Y. Noronha, C. B. Nonino, P. P. Argentato, N. N. Dejani, L. A. Luzia, M. M. Rogero, P. H. C. Rondó
    International Journal of Obesity.2021; 45(9): 1958.     CrossRef
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    Genes.2020; 11(6): 705.     CrossRef
  • Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
    Mebrahtom Gebrelibanos Hiben, Laura de Haan, Bert Spenkelink, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens
    BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
  • UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis
    Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
    Clinical Science.2020; 134(14): 1911.     CrossRef
  • Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
    Ioannis Koutroulis, Rachael Batabyal, Brittany McNamara, Matthew Ledda, Claire Hoptay, Robert J. Freishtat
    Critical Care Explorations.2019; 1(11): e0061.     CrossRef
  • Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus
    Eugene Han, Eugene Shin, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Role of oral hypoglycemic drugs on inflammatory condition associated with type 2 diabetes mellitus
    Shamim Shaikh Mohiuddin
    Journal of Diabetes, Metabolic Disorders & Control.2018; 5(2): 78.     CrossRef
  • Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
    Bong-Hoi Choi, Zhen Jin, Chin-ok Yi, Juhong Oh, Eun Ae Jeong, Jong Youl Lee, Kyung-ah Park, Kyung Eun Kim, Jung Eun Lee, Hyun-Jin Kim, Jong Ryeal Hahm, Gu Seob Roh, Jonathan M Peterson
    PLOS ONE.2018; 13(7): e0200336.     CrossRef
  • Cucurbita ficifolia (Cucurbitaceae) modulates inflammatory cytokines and IFN-γ in obese mice
    Á. Fortis-Barrera, R. García-Macedo, J.C. Almanza-Perez, G. Blancas-Flores, A. Zamilpa-Alvarez, J.L. Flores-Sáenz, M. Cruz, R. Román-Ramos, F.J. Alarcón-Aguilar
    Canadian Journal of Physiology and Pharmacology.2017; 95(2): 170.     CrossRef
  • Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
    Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
    Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
  • Peroxisome proliferator‐activated receptor‐γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
    Brahmchetna Bedi, Nicholas M. Maurice, Vincent T. Ciavatta, K. Sabrina Lynn, Zhihong Yuan, Samuel A. Molina, Myungsoo Joo, William R. Tyor, Joanna B. Goldberg, Michael Koval, C. Michael Hart, Ruxana T. Sadikot
    The FASEB Journal.2017; 31(8): 3608.     CrossRef
  • Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials
    Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren, Jan Westerink
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation
    Shih-Chun Pan, Ching-Chun Huang, Shio-Jean Lin, Bing-Yu Chen, Chang-Chuan Chan, Yue-Liang Leon Guo
    Environmental Research.2017; 158: 318.     CrossRef
  • The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism
    Margherita Maffei, Ilaria Barone, Gaia Scabia, Ferruccio Santini
    Endocrine Reviews.2016; 37(4): 403.     CrossRef
  • Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma
    Brahmchetna Bedi, Zhihong Yuan, Myungsoo Joo, Susu M. Zughaier, Joanna B. Goldberg, Jack L. Arbiser, C. Michael Hart, Ruxana T. Sadikot, B. A. McCormick
    Infection and Immunity.2016; 84(7): 1975.     CrossRef
  • F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
    Kyeong Won Lee, Soo Heon Kwak, Young Do Koo, Yun-Kyung Cho, Hak Mo Lee, Hye Seung Jung, Young Min Cho, Young Joo Park, Sung Soo Chung, Kyong Soo Park
    Experimental & Molecular Medicine.2016; 48(5): e234.     CrossRef
  • The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
    Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • Lobeglitazone and pioglitazone as add‐ons to metformin for patients with type 2 diabetes: a 24‐week, multicentre, randomized, double‐blind, parallel‐group, active‐controlled, phase III clinical trial with a 28‐week extension
    S.‐M. Jin, C.‐Y. Park, Y. M. Cho, B. J. Ku, C. W. Ahn, B.‐S. Cha, K. W. Min, Y. A. Sung, S. H. Baik, K. W. Lee, K.‐H. Yoon, M.‐K. Lee, S. W. Park
    Diabetes, Obesity and Metabolism.2015; 17(6): 599.     CrossRef
  • Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection
    Travis S. Hughes, Henry D. Wilson, Ian Mitchelle S. de Vera, Douglas J. Kojetin, Paul C. Driscoll
    PLOS ONE.2015; 10(8): e0134474.     CrossRef
  • PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
    Flora Aparecida Milton, Aleksandra Cvoro, Angelica A. Amato, Douglas H. Sieglaff, Carly S. Filgueira, Anithachristy Sigamani Arumanayagam, Maria do Carmo Alves de Lima, Ivan Rocha Pitta, Francisco de Assis Rocha Neves, Paul Webb
    Biochemical and Biophysical Research Communications.2015; 464(3): 718.     CrossRef
  • Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity
    Wei-Xin Liu, Ting Wang, Feng Zhou, Ying Wang, Jun-Wei Xing, Shen Zhang, Shou-Zhi Gu, Li-Xuan Sang, Cong Dai, Hai-Lan Wang
    Biochemical and Biophysical Research Communications.2015; 459(3): 475.     CrossRef
  • Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
    Soo Lim, Kuy-Sook Lee, Jie Eun Lee, Ho Seon Park, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Young Bum Kim, Hak Chul Jang
    Atherosclerosis.2015; 243(1): 107.     CrossRef
  • Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
    A.J. Scheen, N. Esser, N. Paquot
    Diabetes & Metabolism.2015; 41(3): 183.     CrossRef
  • Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein
    Yanxiao Zhang, Jingcheng Yu, Chee Lee, Bin Xu, Maureen A. Sartor, Ronald J. Koenig
    Oncotarget.2015; 6(38): 40418.     CrossRef
  • Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
    Santiago Garcia-Vallvé, Laura Guasch, Sarah Tomas-Hernández, Josep Maria del Bas, Vincent Ollendorff, Lluís Arola, Gerard Pujadas, Miquel Mulero
    Journal of Medicinal Chemistry.2015; 58(14): 5381.     CrossRef
  • Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts
    Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim
    Genomics & Informatics.2014; 12(4): 195.     CrossRef
  • Pax-8–PPAR-γ fusion protein in thyroid carcinoma
    Priyadarshini Raman, Ronald J. Koenig
    Nature Reviews Endocrinology.2014; 10(10): 616.     CrossRef
  • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis
    Shinan Yin, Hua Bai, Danqing Jing
    Diagnostic Pathology.2014;[Epub]     CrossRef
  • Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation
    Ajaykumar N. Sharma, Isabelle E. Bauer, Marsal Sanches, Juan F. Galvez, Giovana B. Zunta-Soares, Joao Quevedo, Flavio Kapczinski, Jair C. Soares
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 54: 289.     CrossRef

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