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1 "Islets of Langerhans transplantation"
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Islet Studies and Transplantation
Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells
Yu-Sik Kim, Seung-Woo Cho, Bomin Ko, Jisoo Shin, Chul Woo Ahn
Diabetes Metab J. 2018;42(2):164-168.   Published online March 28, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.164
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AbstractAbstract PDFPubReader   

Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation. Alginate has been considered to be a reliable biomaterial, as it enhances islet survival and does not hamper hormone secretion. Alginate-catechol (Al-CA) hydrogel was reported to provide high mechanical strength and chemical stability without deformation over a wide range of pH values. In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation.

Citations

Citations to this article as recorded by  
  • Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives
    Chandan Maity, Nikita Das
    Topics in Current Chemistry.2022;[Epub]     CrossRef
  • Alginate: Enhancement Strategies for Advanced Applications
    Alejandro Hurtado, Alaa A. A. Aljabali, Vijay Mishra, Murtaza M. Tambuwala, Ángel Serrano-Aroca
    International Journal of Molecular Sciences.2022; 23(9): 4486.     CrossRef
  • Alginate Functionalization for the Microencapsulation of Insulin Producing Cells
    N. A. Len’shina, A. N. Konev, A. A. Baten’kin, P. S. Bardina, E. I. Cherkasova, A. V. Kashina, E. V. Zagainova, V. E. Zagainov, S. A. Chesnokov
    Polymer Science, Series B.2021; 63(6): 640.     CrossRef
  • Strategies to Functionalize the Anionic Biopolymer Na-Alginate without Restricting Its Polyelectrolyte Properties
    Luca Szabó, Sandrine Gerber-Lemaire, Christine Wandrey
    Polymers.2020; 12(4): 919.     CrossRef
  • Catechol-Functionalized Alginate Nanoparticles as Mucoadhesive Carriers for Intravesical Chemotherapy
    Nitjawan Sahatsapan, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opanasopit, Prasopchai Patrojanasophon
    AAPS PharmSciTech.2020;[Epub]     CrossRef

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