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1 "Immunosuppressive agents"
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Sulwon Lecture 2011
Post-Renal Transplant Diabetes Mellitus in Korean Subjects: Superimposition of Transplant-Related Immunosuppressant Factors on Genetic and Type 2 Diabetic Risk Factors
Hyun Chul Lee
Diabetes Metab J. 2012;36(3):199-206.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.199
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  • 9 Crossref
AbstractAbstract PDFPubReader   

Postrenal transplantation diabetes mellitus (PTDM), or new-onset diabetes after organ transplantation, is an important chronic transplant-associated complication. Similar to type 2 diabetes, decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind the development of PTDM. However, β-cell dysfunction rather than insulin resistance seems to be a greater contributing factor in the development of PTDM. Increased age, family history of diabetes, ethnicity, genetic variation, obesity, and hepatitis C are partially accountable for an increased underlying risk of PTDM in renal allograft recipients. In addition, the use of and kinds of immunosuppressive agents are key transplant-associated risk factors. Recently, a number of genetic variants or polymorphisms susceptible to immunosuppressants have been reported to be associated with calcineurin inhibition-induced β-cell dysfunction. The identification of high risk factors of PTDM would help prevent PTDM and improve long-term patient outcomes by allowing for personalized immunosuppressant regimens and by managing cardiovascular risk factors.

Citations

Citations to this article as recorded by  
  • Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience
    Guillermo E. Guzmán, Angela M. Victoria, Isabella Ramos, Alejandro Maldonado, Eliana Manzi, Juan F. Contreras-Valero, Liliana Mesa, Johanna Schweineberg, Juan G. Posada, Jorge I. Villegas, Luis A. Caicedo, Carlos E. Durán
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Synthesis of Fructose Biosensors and Progressing Their Efficiency Using Californium Colloidal Nanoparticles for Detecting Fructose and Triglycerides
    Alireza Heidari
    Advanced Science, Engineering and Medicine.2020; 12(8): 1002.     CrossRef
  • Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
    Hisao Shimada, Junji Uchida, Shunji Nishide, Kazuya Kabei, Akihiro Kosoku, Keiko Maeda, Tomoaki Iwai, Toshihide Naganuma, Yoshiaki Takemoto, Tatsuya Nakatani
    Journal of Clinical Medicine.2019; 8(7): 920.     CrossRef
  • Diabètes post-transplantation rénale
    Danièle Dubois-Laforgue
    Néphrologie & Thérapeutique.2017; 13: S137.     CrossRef
  • Risk assessment and management of post-transplant diabetes mellitus
    Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Metabolism.2016; 65(10): 1559.     CrossRef
  • Renal posttransplantation diabetes mellitus: An overview
    Ana Laura Pimentel, Andrea Carla Bauer, Joíza Lins Camargo
    Clinica Chimica Acta.2015; 450: 327.     CrossRef
  • HMG CoA Reductase Inhibitor Treatment Induces Dysglycemia in Renal Allograft Recipients
    Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Yongin Cho, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang
    Transplantation.2014; 97(4): 419.     CrossRef
  • Statin therapy is associated with the development of new-onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels
    Yongin Cho, Min Jung Lee, Eun Yeong Choe, Chang Hee Jung, Dong Jin Joo, Myoung Soo Kim, Bong Soo Cha, Joong-Yeol Park, Eun Seok Kang
    Liver Transplantation.2014; 20(5): 557.     CrossRef
  • Post-Transplant Diabetes Mellitus: Is It Associated With Poor Allograft Outcomes in Renal Transplants?
    J.Y. Choi, O.J. Kwon
    Transplantation Proceedings.2013; 45(8): 2892.     CrossRef

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