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Review
- Pathophysiology
- Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
- Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim
- Diabetes Metab J. 2024;48(1):37-52. Published online January 3, 2024
- DOI: https://doi.org/10.4093/dmj.2023.0193
- 25,686 View
- 698 Download
- 13 Web of Science
- 14 Crossref
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Abstract
PDF
PubReader 
ePub - Novel strategies are required to reduce the risk of developing diabetes and/or clinical outcomes and complications of diabetes. In this regard, the role of the circadian system may be a potential candidate for the prevention of diabetes. We reviewed evidence from animal, clinical, and epidemiological studies linking the circadian system to various aspects of the pathophysiology and clinical outcomes of diabetes. The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events through interactions between a “central clock” in the suprachiasmatic nucleus and “peripheral clocks” in the whole body. Currently, circadian rhythmicity in humans can be subjectively or objectively assessed by measuring melatonin and glucocorticoid levels, core body temperature, peripheral blood, oral mucosa, hair follicles, rest-activity cycles, sleep diaries, and circadian chronotypes. In this review, we summarized various circadian misalignments, such as altered light-dark, sleep-wake, rest-activity, fasting-feeding, shift work, evening chronotype, and social jetlag, as well as mutations in clock genes that could contribute to the development of diabetes and poor glycemic status in patients with diabetes. Targeting critical components of the circadian system could deliver potential candidates for the treatment and prevention of type 2 diabetes mellitus in the future.
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Citations
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Chronobiology International.2026; 43(1): 104. CrossRef - Unraveling the Tapestry of Health: The Intricate Dance of Circadian Rhythms and Human Diseases
Sidrah Parvez, Andrej Dzupina, Ghizal Fatima, Najah Hadi, Jan Fedacko, Aminat Magomedova, Ammar Mehdi Raza, Nasser Ghaly Yousif, Hekmat B. Alhmadi
Bratislava Medical Journal.2026; 127(2): 492. CrossRef - Diabetes and its complications: molecular mechanisms, prevention and treatment
Lijun Zhao, Jiamin Yuan, Qing Yang, Jing Ma, Fenghao Yang, Yutong Zou, Ke Liu, Fang Liu
Signal Transduction and Targeted Therapy.2026;[Epub] CrossRef - Prediabetes is a window of opportunity for preventive interventions. Part 2
T. V. Adasheva, E. E. Gubernatorova, E. I. Fomina, E. G. Lobanova
Meditsinskiy sovet = Medical Council.2026; (23): 123. CrossRef - Association of daytime circadian-aligned activity with glycemic control in type 2 diabetes: Insights from continuous glucose monitoring and wearable data
Da Young Lee, Jung-Been Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Heon-Jeong Lee, Nan Hee Kim
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INDIAN DRUGS.2026; 63(03): 8. CrossRef - Chrononutrition: Potential, Challenges, and Application in Managing Obesity
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International Journal of Molecular Sciences.2025; 26(11): 5116. CrossRef - Chrononutrition and Energy Balance: How Meal Timing and Circadian Rhythms Shape Weight Regulation and Metabolic Health
Claudia Reytor-González, Daniel Simancas-Racines, Náthaly Mercedes Román-Galeano, Giuseppe Annunziata, Martina Galasso, Raynier Zambrano-Villacres, Ludovica Verde, Giovanna Muscogiuri, Evelyn Frias-Toral, Luigi Barrea
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Molecular and Cellular Biochemistry.2025; 480(12): 5995. CrossRef - Chrononutrition and sleep patterns in individuals with diabetes mellitus: Assessing misalignments and social jetlag
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- Late-eating adolescents consume more energy, make poorer dietary choices, and are more likely to have excess weight: An analysis of the Brazilian Household Budget Survey (2008–2009)
Original Article
- Role of Glucocorticoid Receptor on Insulin Secretion and Synthesis in INS-1 Cells.
- Ju Yeon Yang, Myong Su Kang, Tak Ho Song, In Kook Jeong, Pyong Ju Seo, Hee Jin Kim
- Korean Diabetes J. 2006;30(6):428-434. Published online November 1, 2006
- DOI: https://doi.org/10.4093/jkda.2006.30.6.428
- 2,932 View
- 47 Download
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Abstract
PDF
- BACKGROUND
Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids on insulin secretion and synthesis in pancreatic beta cells are still unclear. We have investigated the direct effects of glucocorticoids on insulin secretion and synthesis in rat insulinoma (INS-1) cells. METHODS: Insulin content and 11.2 mM glucose-stimulated insulin secretion (GSIS) were measured in INS-1 cells after culture with or without 1 micrometer dexamethasone (DEX). Preproinsulin mRNA levels were analyzed by real-time RT-PCR and normalized to the internal control. Effect of RU486 on DEX-induced inhibition of GSIS and preproinsulin mRNA synthesis was evaluated. RESULTS: Insulin content of INS-1 cells cultured in RPMI containing 11.2 mM glucose in the presence of DEX was not different from that of control cells. After 1-h preincubation in 2.8 mM glucose, basal insulin secretion from cells treated with DEX did not differ from that of controls, but GSIS was significantly reduced in the cells treated with DEX in comparison to control cells. The expression of preproinsulin mRNA relative to beta-actin mRNA was also lower in the cells treated with DEX. Glucocorticoid receptor antagonist improved DEX-induced inhibition of GSIS and preproinsulin mRNA synthesis. CONCLUSION: DEX inhibited GSIS and preproinsulin mRNA synthesis in INS-1 cells. Glucocorticoid receptor antagonist ameliorated the reduced GSIS and preproinsulin mRNA synthesis induced by DEX.
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