Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Glucagon stimulation test"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients
Hye-Jin Yoon, Youn-Zoo Cho, Ji-young Kim, Byung-Joon Kim, Keun-Young Park, Gwan-Pyo Koh, Dae-Ho Lee, Dong-Mee Lim
Diabetes Metab J. 2012;36(5):379-387.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.379
  • 5,808 View
  • 43 Download
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM).

Methods

A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed.

Results

In patients with retinopathy, basal C-peptide was 1.9±1.2 ng/mL, and stimulated C-peptide was 2.7±1.6 ng/mL; values were significantly lower compared with patients without retinopathy (P=0.031 and P=0.002, respectively). In patients with nephropathy, basal C-peptide was 1.6±0.9 ng/mL, and stimulated C-peptide was 2.8±1.6 ng/mL; values were significantly lower than those recorded in patients without nephropathy (P=0.020 and P=0.026, respectively). Stimulated C-peptide level was associated with increased prevalence of microvascular complications. Age-, DM duration-, and hemoglobin A1c-adjusted odds ratios for retinopathy in stimulated C-peptide value were 4.18 (95% confidence interval [CI], 1.40 to 12.51) and 3.35 (95% CI, 1.09 to 10.25), respectively. The multiple regression analysis between nephropathy and C-peptide showed that stimulated C-peptide was statistically correlated with nephropathy (P=0.03).

Conclusion

In patients with type 2 diabetes, the glucagon stimulation test was a relatively simple method of short duration for stimulating C-peptide response. Stimulated C-peptide values were associated with microvascular complications to a greater extent than basal C-peptides.

Citations

Citations to this article as recorded by  
  • A Nomogram for Predicting Vision-Threatening Diabetic Retinopathy Among Mild Diabetic Retinopathy Patients: A Case–Control and Prospective Study of Type 2 Diabetes
    Jing Ke, Kun Li, Bin Cao
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 275.     CrossRef
  • The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study
    Ting Pan, Jie Gao, Xinghua Cai, Huihui Zhang, Jun Lu, Tao Lei
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Dysregulation of miR-374a is involved in the progression of diabetic retinopathy and regulates the proliferation and migration of retinal microvascular endothelial cells
    Zhanhong Wang, Xiao Zhang, Yanjun Wang, Dailing Xiao
    Clinical and Experimental Optometry.2022; 105(3): 287.     CrossRef
  • The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey
    Hye Eun Cho, Seung Bum Yang, Mi Young Gi, Ju Ae Cha, so Young Park, Hyun Yoon
    Endocrine Research.2022; 47(2): 80.     CrossRef
  • Effects of Serum C-Peptide Level on Blood Lipid and Cardiovascular and Cerebrovascular Injury in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis
    Juan Qin, Rongli Sun, Ding Ding, Yuvaraja Teekaraman
    Contrast Media & Molecular Imaging.2022; 2022: 1.     CrossRef
  • Investigation of Diabetes Complication Risk Perception and Diabetes Self-Management Skills in Individuals with Diabetes
    Mehmet AYTEMUR, Bahar İNKAYA
    Turkish Journal of Diabetes and Obesity.2022; 6(2): 121.     CrossRef
  • Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness
    Eli Ipp
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association of C-peptide with diabetic vascular complications in type 2 diabetes
    Y. Wang, H. Wan, Y. Chen, F. Xia, W. Zhang, C. Wang, S. Fang, K. Zhang, Q. Li, N. Wang, Y. Lu
    Diabetes & Metabolism.2020; 46(1): 33.     CrossRef
  • Variations in glucose/C-peptide ratio in patients with type 2 diabetes associated with renal function
    John A. D'Elia, Christopher Mulla, Jiankang Liu, Larry A. Weinrauch
    Diabetes Research and Clinical Practice.2019; 150: 1.     CrossRef
  • The pharmacokinetics of porcine C‐peptide after intraperitoneal injection
    Naho Iizuka, Masuhiro Nishimura, Yasutaka Fujita, Osamu Sawamoto, Shinichi Matsumoto
    Xenotransplantation.2019;[Epub]     CrossRef
  • Association of KCNJ11(RS5219) gene polymorphism with biochemical markers of glycemic status and insulin resistance in gestational diabetes mellitus
    Lenin M, Ramesh Ramasamy, Sweta Kulkarani, Seetesh Ghose, Srinivasan A.R.S., Sathish Babu M
    Meta Gene.2018; 16: 134.     CrossRef
  • Glucagon secretion is increased in patients with Type 2 diabetic nephropathy
    Xiaoyu Wang, Juhong Yang, Baocheng Chang, Chunyan Shan, Yanguang Xu, Miaoyan Zheng, Ying Wang, Huizhu Ren, Liming Chen
    Journal of Diabetes and its Complications.2016; 30(3): 488.     CrossRef
  • Relationship between serum C-peptide level and diabetic retinopathy according to estimated glomerular filtration rate in patients with type 2 diabetes
    Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
    Journal of Diabetes and its Complications.2015; 29(3): 350.     CrossRef
  • Independent association between serum C‐peptide levels and fat mass‐to‐lean mass ratio in the aging process
    Ying Li, Lian Shun Zheng, Yue Li, Duo Duo Zhao, Lu Meng
    Geriatrics & Gerontology International.2015; 15(7): 918.     CrossRef
  • Relationship Between β-Cell Function, Metabolic Control, and Microvascular Complications in Type 2 Diabetes Mellitus
    Lihua Zhao, Jing Ma, Shaoxin Wang, Yun Xie
    Diabetes Technology & Therapeutics.2015; 17(1): 29.     CrossRef
  • Association of fasting insulin and C peptide with diabetic retinopathy in Latinos with type 2 diabetes
    Jane Z Kuo, Xiuqing Guo, Ronald Klein, Barbara E Klein, Robert N Weinreb, Pauline Genter, Fone-Ching Hsiao, Mark O Goodarzi, Jerome I Rotter, Yii-Der Ida Chen, Eli Ipp
    BMJ Open Diabetes Research & Care.2014; 2(1): e000027.     CrossRef
  • Association between physical activity and serum C‐peptide levels among the elderly
    Ying Li, Lu Meng, QianQian Miao, Yasuto Sato
    Geriatrics & Gerontology International.2014; 14(3): 647.     CrossRef
  • Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese
    Xiaoling Cai, Xueyao Han, Simin Zhang, Yingying Luo, Yingli Chen, Linong Ji, Alfred S. Lewin
    PLoS ONE.2014; 9(3): e91174.     CrossRef
  • Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset Type 1 and Type 2 Diabetes
    Ramachandran Rajalakshmi, Anandakumar Amutha, Harish Ranjani, Mohammed K. Ali, Ranjit Unnikrishnan, Ranjit Mohan Anjana, K.M. Venkat Narayan, Viswanathan Mohan
    Journal of Diabetes and its Complications.2014; 28(3): 291.     CrossRef
  • Prediction of response to GLP-1 receptor agonist therapy in Japanese patients with type 2 diabetes
    Kenjiro Imai, Tetsuro Tsujimoto, Atsushi Goto, Maki Goto, Miyako Kishimoto, Ritsuko Yamamoto-Honda, Hiroshi Noto, Hiroshi Kajio, Mitsuhiko Noda
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
  • The Association between the Serum C-Peptide Level and Bone Mineral Density
    Ying Li, Hua Liu, Yasuto Sato, Bin He
    PLoS ONE.2013; 8(12): e83107.     CrossRef
  • C-Peptide and Its Career from Innocent Bystander to Active Player in Diabetic Atherogenesis
    Corinna Lebherz, Nikolaus Marx
    Current Atherosclerosis Reports.2013;[Epub]     CrossRef
  • C-Peptide and Vascular Complications in Type 2 Diabetic Subjects
    Seok Man Son
    Diabetes & Metabolism Journal.2012; 36(5): 345.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal