Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine.

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• Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
  Jeffrey Cummings, Andrew Ortiz, Janelle Castellino, Jefferson Kinney
  European Journal of Neuroscience.2022; 56(9): 5727.     CrossRef
• Association of gene polymorphisms with body weight changes in prediabetic patients
  Farida V. Valeeva, Mariya S. Medvedeva, Kamilya B. Khasanova, Elena V. Valeeva, Tatyana A. Kiseleva, Emiliya S. Egorova, Craig Pickering, Ildus I. Ahmetov
  Molecular Biology Reports.2022; 49(6): 4217.     CrossRef
• Analysis of the association of FTO, PPARG and PPARGC1A gene polymorphisms with carbohydrate metabolism disorders
  Farida V. Valeeva, Kamilya B. Khasanova, Elizaveta A. Sozinova, Tatyana A. Kiseleva, Elena V. Valeeva, Emiliya S. Egorova, Ildus I. Ahmetov
  Kazan medical journal.2022; 103(4): 592.     CrossRef
• Associations between new and old anthropometric indices with type 2 diabetes mellitus and risk of metabolic complications: a cross-sectional analytical study
  Parichehr Amiri, Ahmad Zare Javid, Leila Moradi, Neda Haghighat, Rahim Moradi, Hossein Bavi Behbahani, Milad Zarrin, Hadi Bazyar
  Jornal Vascular Brasileiro.2021;[Epub]     CrossRef
• When will individuals meet their personalized probabilities? A philosophical note on risk prediction
  Olaf M. Dekkers, Jesse M. Mulder
  European Journal of Epidemiology.2020; 35(12): 1115.     CrossRef
• From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research
  Radia Khan, Zoey Chua, Jia Tan, Yingying Yang, Zehuan Liao, Yan Zhao
  Medicina.2019; 55(9): 546.     CrossRef
• Systematic analysis of genes and diseases using PheWAS-Associated networks
  Ali Khosravi, Morteza Kouhsar, Bahram Goliaei, B. Jayaram, Ali Masoudi-Nejad
  Computers in Biology and Medicine.2019; 109: 311.     CrossRef
• Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model
  Wen Sun, Guangyuan Xu, Xuan Guo, Guangbin Luo, Lili Wu, Yi Hou, Xiangyu Guo, Jingxin Zhou, Tunhai Xu, Lingling Qin, Yixin Fan, Li Han, Motlalepula Matsabisa, Xuesheng Ma, Tonghua Liu
  Molecular Medicine Reports.2017; 16(2): 1333.     CrossRef
• Are We in the Same Risk of Diabetes Mellitus? Gender- and Age-Specific Epidemiology of Diabetes in 2001 to 2014 in the Korean Population
  Bo Kyung Koo, Min Kyong Moon
  Diabetes & Metabolism Journal.2016; 40(3): 175.     CrossRef
• Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes
  Donghe Li, Sungho Won
  Genomics & Informatics.2016; 14(4): 160.     CrossRef
• Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus
  Nor Bahirah Kasim, Hasniza Zaman Huri, Shireene Ratna Vethakkan, Luqman Ibrahim, Bashar Mudhaffar Abdullah
  Biomarkers in Medicine.2016; 10(4): 403.     CrossRef
• A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes
  Narsingh Verma, Kauser Usman, Naresh Patel, Arvind Jain, Sudhir Dhakre, Anand Swaroop, Manashi Bagchi, Pawan Kumar, Harry G. Preuss, Debasis Bagchi
  Food & Nutrition Research.2016; 60(1): 32382.     CrossRef
• Association between -308G/A TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review
  Geisa Izetti Luna, Izabel Cristina Rodrigues da Silva, Mauro Niskier Sanchez
  Journal of Diabetes Research.2016; 2016: 1.     CrossRef
• Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes
  Mohamad Hafizi Abu Bakar, Mohamad Roji Sarmidi, Kian-Kai Cheng, Abid Ali Khan, Chua Lee Suan, Hasniza Zaman Huri, Harisun Yaakob
  Molecular BioSystems.2015; 11(7): 1742.     CrossRef
• Predictive modeling for incident and prevalent diabetes risk evaluation
  Katya L Masconi, Justin Basile Echouffo-Tcheugui, Tandi E Matsha, Rajiv T Erasmus, Andre Pascal Kengne
  Expert Review of Endocrinology & Metabolism.2015; 10(3): 277.     CrossRef
• Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
  Elena Vladimirovna Kazakova, Yanhui Wu, Meijun Chen, Tongtong Wang, Lulu Sun, Hong Qiao
  Diabetes mellitus.2015; 18(3): 46.     CrossRef
• The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings
  Noraidatulakma Abdullah, John Attia, Christopher Oldmeadow, Rodney J. Scott, Elizabeth G. Holliday
  International Journal of Endocrinology.2014; 2014: 1.     CrossRef
• Translational medicine as a new clinical tool and application which improves metabolic diseases: perspectives from 2012 Sino‐American symposium on clinical and translational medicine
  Lin Shi, Elena López Villar, Chengshui Chen
  Clinical and Translational Medicine.2014;[Epub]     CrossRef
• Frequency of Fat Mass and Obesity-Associated Gene rs9939609 and Peroxisome Proliferator-Activated Receptor Gamma 2 Gene rs1801282 Polymorphisms among Trinidadian Neonates of Different Ethnicities and Their Relationship to Anthropometry at Birth
  Candace E. Cuthbert, D. Dan Ramdath, Jerome E. Foster
  Lifestyle Genomics.2014; 7(1): 39.     CrossRef
• Genetics of type 2 diabetes and potential clinical implications
  Soo Heon Kwak, Kyong Soo Park
  Archives of Pharmacal Research.2013; 36(2): 167.     CrossRef
• Genetics in Diabetes Mellitus - Contribution to the Classification and Management
  Jeesuk Yu
  Annals of Pediatric Endocrinology & Metabolism.2012; 17(4): 211.     CrossRef
• Genome-wide association studies with metabolomics
  Jerzy Adamski
  Genome Medicine.2012; 4(4): 34.     CrossRef
• Typ-2-Diabetes-assoziierte Gene
  J. Kriebel, H. Grallert, T. Illig
  Der Diabetologe.2012; 8(1): 26.     CrossRef