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Original Articles
- Obesity and Metabolic Syndrome
- Increased Risk of Progression of Coronary Artery Calcification in Male Subjects with High Baseline Waist-to-Height Ratio: The Kangbuk Samsung Health Study
- Hyung-Geun Oh, Shriram Nallamshetty, Eun-Jung Rhee
- Diabetes Metab J. 2016;40(1):54-61. Published online February 19, 2016
- DOI: https://doi.org/10.4093/dmj.2016.40.1.54
- 4,081 View
- 30 Download
- 10 Web of Science
- 12 Crossref
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Abstract
PDF
PubReader Background The waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of baseline WHtR and progression of coronary artery calcification (CAC) over 4 years of follow-up in apparently healthy Korean men.
Methods A total of 1,048 male participants (mean age, 40.9 years) in a health-screening program in Kangbuk Samsung Hospital, Seoul, Korea who repeated a medical check-up in 2010 and 2014 were recruited. Baseline WHtR was calculated using the value for the waist in 2010 divided by the value for height in 2010. The CAC score (CACS) of each subject was measured by multi-detector computed tomography in both 2010 and 2014. Progression of CAC was defined as a CACS change over 4 years greater than 0.
Results During the follow-up period, progression of CAC occurred in 278 subjects (26.5%). The subjects with CAC progression had slightly higher but significant baseline WHtR compared to those who did not show CAC progression (0.51±0.04 vs. 0.50±0.04,
P <0.01). The proportion of subjects with CAC progression significantly increased as the baseline WHtR increased from the 1st quartile to 4th quartile groups (18.3%, 18.7%, 28.8%, and 34.2%;P <0.01). The risk for CAC progression was elevated with an odds ratio of 1.602 in the 4th quartile group of baseline WHtR even after adjustment for confounding variables (95% confidence interval, 1.040 to 2.466).Conclusion Increased baseline WHtR was associated with increased risk for CAC progression. WHtR might be a useful screening tool to identify individuals at high risk for subclinical atherosclerosis.
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Citations
Citations to this article as recorded by
- Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis
Mahmood Shaker Khazaal, Farqad Bader Hamdan, Qasim Sharhan Al-Mayah
Journal of Medicine and Life.2023; 16(3): 463. CrossRef - Differences in the number of stented coronary arteries based on the seven traditional obesity parameters among patients with coronary artery diseases undergoing cardiac catheterization
Audai A Hayajneh, Islam M Alhusban, Mohammad Rababa, Sami Al-Rawashdeh, Shatha Al-Sabbah, Dania Bani-Hamad
Electronic Journal of General Medicine.2022; 19(5): em391. CrossRef - Predictive Model for High Coronary Artery Calcium Score in Young Patients with Non-Dialysis Chronic Kidney Disease
Tae Ryom Oh, Su Hyun Song, Hong Sang Choi, Sang Heon Suh, Chang Seong Kim, Ji Yong Jung, Kyu Hun Choi, Kook-Hwan Oh, Seong Kwon Ma, Eun Hui Bae, Soo Wan Kim
Journal of Personalized Medicine.2021; 11(12): 1372. CrossRef - Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
Aldo Javier Vázquez Mézquita, Michelle Claire Williams, Rafael Choza Chenhalls, Nancy Berenice Guzmán Martínez, Ana Patricia Chischistz Condey, Maria José Acosta Falomir, Marco Antonio Téliz Meneses, María Nayeli Vázquez Sánchez
SAGE Open Medicine.2020; 8: 205031212093823. CrossRef - The association of waist-to-height ratio and other anthropometric measurements with subclinical atherosclerosis: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Rosana Raele, Paulo A. Lotufo, Marcio S. Bittencourt, Maria de Jesus M. Fonseca, Alessandra C. Goulart, Itamar S. Santos, Isabela M. Bensenor
Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(11): 1989. CrossRef - The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
Jung-Hwan Cho, Eun-Jung Rhee, Se-Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Hye Soon Park, Yang-Hyun Kim, Soon-Jib Yoo, Won-Young Lee
Diabetes & Metabolism Journal.2019; 43(2): 206. CrossRef - Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
Eun-Jung Rhee
Diabetes & Metabolism Journal.2018; 42(1): 19. CrossRef - The renal tubular damage marker urinary N-acetyl-β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes
So Ra Kim, Yong-ho Lee, Sang-Guk Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Cardiovascular Diabetology.2017;[Epub] CrossRef - Influencia de la actividad física y el consumo calórico sobre la adiposidad visceral en adultos de la ciudad de Cuenca, Ecuador
Rina Ortiz, Maritza Torres, Wilson Siguencia, Nube Sigüenza-Cobos, Juan Salazar, Roberto Añez, Joselyn Rojas, Valmore Bermúdez
Revista Argentina de Endocrinología y Metabolismo.2017; 54(4): 160. CrossRef - The association between various indices of obesity and severity of atherosclerosis in adults in the north of Iran
Arsalan Salari, Maryam Shakiba, Marjan Mahdavi-Roshan, Mahboobeh Gholipour, Moona Naghshbandi, Ramin Rajabi
Medicine.2016; 95(50): e5670. CrossRef - Diet Quality and Mortality Risk in Metabolically Obese Normal-Weight Adults
Yong-Moon Mark Park, Teresa T. Fung, Susan E. Steck, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T. Merchant
Mayo Clinic Proceedings.2016; 91(10): 1372. CrossRef - Waist Circumference as a Marker of Obesity Is More Predictive of Coronary Artery Calcification than Body Mass Index in Apparently Healthy Korean Adults: The Kangbuk Samsung Health Study
Jongsin Park, Eun Seo Lee, Da Young Lee, Jihyun Kim, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinology and Metabolism.2016; 31(4): 559. CrossRef
- Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis
- ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
- Dae Joon Jeong, Dong Gyu Lee, Hee-Jung Kim, Eun Hee Cho, Sang-Wook Kim
- Korean Diabetes J. 2010;34(5):320-326. Published online October 31, 2010
- DOI: https://doi.org/10.4093/kdj.2010.34.5.320
- 4,148 View
- 35 Download
- 4 Crossref
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Abstract
PDFPubReader
Background Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients.
Methods The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified.
Results The prevalence of subjects carrying the KQ genotype was 12.9% (
n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18;P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959).Conclusions The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
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Citations
Citations to this article as recorded by- Evaluation of NPP1 as a Novel Biomarker of Coronary Artery Disease: A Pilot Study in Human Beings
Amir Hooshang Mohammadpour, Saeed Nazemi, Fatemeh Mashhadi, Atefeh Rezapour, Mohammad Afshar, Sepideh Afzalnia, Afsaneh Mohammadi, Hamid Reza Mashreghi Moghadam, Maryam Moradian, Seyed Mohammad Hasan Moallem, Saeed Falahaty, Azadeh Zayerzadeh, Sepideh Ely
Advanced Pharmaceutical Bulletin.2018; 8(3): 489. CrossRef - ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus
S. Sumi, Surya Ramachandran, V RamanKutty, Maulin M. Patel, T. N. Anand, Ajit S Mullasari, C. C. Kartha
Molecular and Cellular Biochemistry.2017; 435(1-2): 67. CrossRef - Genetics in Arterial Calcification
Frank Rutsch, Yvonne Nitschke, Robert Terkeltaub, Dwight A. Towler
Circulation Research.2011; 109(5): 578. CrossRef - Distribution of allelic variants of genes inhibitors and activators ectopic calcification in patients with acute coronary syndrome
V. Yu. Harbuzova, O. A. Obukhova, I. O. Rozumenko, Ye. I. Dubovyk, T. M. Oleshko, Ye. A. Harbuzova, D. V. Shvachko, O. V. Ataman
Faktori eksperimental'noi evolucii organizmiv.1970; 21: 306. CrossRef
- Evaluation of NPP1 as a Novel Biomarker of Coronary Artery Disease: A Pilot Study in Human Beings
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