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Diabetes Metab J : Diabetes & Metabolism Journal



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Original Article
The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension
Ji Hyun Kim, Su Jin Oh, Jung Min Lee, Eun Gyoung Hong, Jae Myung Yu, Kyung Ah Han, Kyung Wan Min, Hyun Shik Son, Sang Ah Chang
Diabetes Metab J. 2011;35(3):236-242.   Published online June 30, 2011
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AbstractAbstract PDFPubReader   

Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with type 2 diabetes and hypertension.


We used pulse wave analysis to measure central aortic waveform in a total of 98 subjects. In 47 of these patients, pulse wave velocity measurements were obtained before and after 12 weeks of treatment with valsartan.


In the central aortic waveform analysis, the aortic pulse pressure and augmentation index were significantly decreased after valsartan treatment, as was the aortic pulse wave velocity. Factors contributing to the improvement in pulse wave velocity were the fasting blood glucose and haemoglobin A1c levels.


Short-term treatment with valsartan improves arterial stiffness in patients with type 2 diabetes and hypertension, and the glucose status at baseline was associated with this effect.


Citations to this article as recorded by  
  • Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial
    Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte
    Diabetes, Obesity and Metabolism.2023; 25(1): 198.     CrossRef
  • Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome
    Ami B Bhatt, J Stewart Buck, Jonah P Zuflacht, Jessica Milian, Samoneh Kadivar, Kimberlee Gauvreau, Michael N Singh, Mark A Creager
    Vascular Medicine.2015; 20(4): 317.     CrossRef
  • The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis
    Feng Peng, Hongming Pan, Bin Wang, Jinxiu Lin, Wenquan Niu
    Hypertension Research.2015; 38(9): 613.     CrossRef
  • Arterial stiffness in atherosclerotic renovascular hypertension
    Ljiljana Fodor, Vedran Premužić, Vanja Ivković, Dražen Perkov, Mario Laganović, Tajana Željković Vrkić, Živka Dika, Marijana Živko, Bojan Jelaković
    Journal of Hypertension.2014; 32(11): 2238.     CrossRef
  • Improvement of arterial wall characteristics by the low-dose fluvastatin and valsartan combination in type 1 diabetes mellitus patients
    Vedran Savić, Barbara Eržen, Miodrag Janić, Mojca Lunder, Maja Boncelj, Karin Kanc, Andrej Janež, Mišo Šabovič
    Diabetes and Vascular Disease Research.2013; 10(5): 420.     CrossRef
  • The association between regional arterial stiffness and diabetic retinopathy in type 2 diabetes
    Won Jun Kim, Cheol-Young Park, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim, SuJeong Song
    Atherosclerosis.2012; 225(1): 237.     CrossRef
  • Letter: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42)
    Chul-Hee Kim
    Diabetes & Metabolism Journal.2011; 35(4): 427.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal