Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.

Jun Hwa Hong; Ji Hye Lee; Jong Ho Shin; Dong Pil Kim; Bong Suk Ko; Byung Joon Kim; Hyun Jin Kim; Kang Seo Park

doi:10.4093/kdj.2008.32.6.529

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Case Report Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.: Jun Hwa Hong, Ji Hye Lee, Jong Ho Shin, Dong Pil Kim, Bong Suk Ko, Byung Joon Kim, Hyun Jin Kim, Kang Seo Park; Diabetes & Metabolism Journal 2008;32(6):529-531
DOI: https://doi.org/10.4093/kdj.2008.32.6.529
Published online: December 1, 2008

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Department of Internal Medicine, Eulji University School of Medicine, Korea.

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Abstract

Allergic reaction to human insulin is uncommon. But they can cause mild to severe symptoms such as dyspnea, hypotensive shock, etc. Here we report the case of a patient with type 2 diabetes and insulin allergy successfully managed with desensitization. A 60-year-old man with insulin allergy was transferred. He had poorly controlled type 2 diabetes (fasting blood glucose 230 mg/dL). He developed itching sense and erythema at the injection sites of human insulin in a few minutes. And serum IgE level was elevated to 1618.0 IU/mL. The insulin was changed to other preparations, including short and long-acting insulin analogues, with similar responses. He was commenced on twice a day injection protocol in addition to his oral hypoglycemic agents, and achieved fair control (fasting blood glucose 100 mg/dL) on 24 units of Novomix Flex Pen per day, with little or no skin or systemic reaction. This is the case report of insulin allergy in type 2 diabetes being successfully managed by desensitization.

Keywords: Allergy;Desensitization;Insulin;

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Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.

Korean Diabetes J. 2008;32(6):529-531. Published online December 1, 2008

DOI: https://doi.org/10.4093/kdj.2008.32.6.529

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