Diabetes & Metabolism Journal

Original Articles

Metabolic Risk/Epidemiology
Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults: Jonghwa Jin, Hyein Woo, Youngeun Jang, Won-Ki Lee, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi; Diabetes Metab J. 2023;47(3):426-436. Published online March 6, 2023; DOI: https://doi.org/10.4093/dmj.2022.0099

2,510 View
128 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.
Methods
A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.
Results
The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women.
Conclusion
CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.

Citations

Citations to this article as recorded by

Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study
Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng, Xianliang Zhou
Journal of Translational Medicine.2023;[Epub] CrossRef

Metabolic Risk/Epidemiology
Sex Differences of Visceral Fat Area and Visceral-to-Subcutaneous Fat Ratio for the Risk of Incident Type 2 Diabetes Mellitus: Eun Hee Kim, Hong-Kyu Kim, Min Jung Lee, Sung-Jin Bae, Jaewon Choe, Chang Hee Jung, Chul-Hee Kim, Joong-Yeol Park, Woo Je Lee; Diabetes Metab J. 2022;46(3):486-498. Published online November 18, 2021; DOI: https://doi.org/10.4093/dmj.2021.0095

9,319 View
367 Download
19 Web of Science
22 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
This study aimed to determine the optimal cut-off values of visceral fat area (VFA) and visceral-to-subcutaneous fat ratio (VSR) for predicting incident type 2 diabetes mellitus (T2DM).
Methods
A total of 10,882 individuals (6,835 men; 4,047 women) free of T2DM at baseline aged between 30 and 79 years who underwent abdominal computed tomography scan between 2012 and 2013 as a part of routine health check-ups were included and followed. VFA, subcutaneous fat area, and VSR on L3 vertebral level were measured at baseline.
Results
During a median follow-up of 4.8 years, 730 (8.1% for men; 4.3% for women) incident cases of T2DM were identified. Receiver operating characteristic curve analysis showed that the optimal cut-off values of VFA and VSR for predicting incident T2DM were 130.03 cm² and 1.08 in men, respectively, and 85.7 cm² and 0.48 in women, respectively. Regardless of sex, higher VFA and VSR were significantly associated with a higher risk of incident T2DM. Compared with the lowest quartiles of VFA and VSR, the highest quartiles had adjusted odds ratios of 2.62 (95% confidence interval [CI], 1.73 to 3.97) and 1.55 (95% CI, 1.14 to 2.11) in men, respectively, and 32.49 (95% CI, 7.42 to 142.02) and 11.07 (95% CI, 3.89 to 31.50) in women, respectively.
Conclusion
Higher VFA and VSR at baseline were independent risk factors for the development of T2DM. Sex-specific reference values for visceral fat obesity (VFA ≥130 cm² or VSR ≥1.0 in men; VFA ≥85 cm² or VSR ≥0.5 in women) are proposed for the prediction of incident T2DM.

Citations

Citations to this article as recorded by

Severity of adipose tissue dysfunction is associated with progression of pre-diabetes to type 2 diabetes: the Tehran Lipid and Glucose Study
Mohammad Jalali, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Farhad Hosseinpanah
BMC Public Health.2024;[Epub] CrossRef
Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models
Huan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Tetsuya Mizoue
BMJ Open Diabetes Research & Care.2024; 12(1): e003680. CrossRef
Adipose organ dysfunction and type 2 diabetes: Role of nitric oxide
Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi
Biochemical Pharmacology.2024; 221: 116043. CrossRef
Prediction of high visceral adipose tissue for sex‐specific community residents in Taiwan
Yu‐Hsuan Chang, Chin‐Sung Chang, Chieh‐Yu Liu, Yin‐Fan Chang, Shiow‐Ching Shun
Nursing & Health Sciences.2024;[Epub] CrossRef
Guidelines for obesity clinic consultations in primary healthcare clinics
Jee-Hyun Kang, Kyoung-Kon Kim
Journal of the Korean Medical Association.2024; 67(4): 240. CrossRef
Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study
Fan Wu, Yanlan Liu, Chenying Lin, Nahal Haghbin, Longfei Xia, Yaoshuang Li, Tong Chen, Huina Qiu, Weiran Jiang, Jingbo Li, Jingna Lin
BMC Geriatrics.2024;[Epub] CrossRef
Body Composition and Metabolic Dysfunction Really Matter for the Achievement of Better Outcomes in High-Grade Serous Ovarian Cancer
Mauricio A. Cuello, Fernán Gómez, Ignacio Wichmann, Felipe Suárez, Sumie Kato, Elisa Orlandini, Jorge Brañes, Carolina Ibañez
Cancers.2023; 15(4): 1156. CrossRef
MEDICINAL BIOMAGNETISM FOR THE TREATMENT OF OBESITY
Ana Vergínia Campagnollo Bueno, Michelli Gonçalves Seneda, Ângela Mara Rambo, Ana Clara Campagnolo Gonçalves Toledo, Caroline Cabral de Azevedo, Adriane Viapiana Bossa
Health and Society.2023; 3(01): 411. CrossRef
Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
Min-Kyung Lee, Jae-Hyuk Lee, Seo Young Sohn, Jiyeon Ahn, Oak-Kee Hong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef
The correlation between visceral fat/subcutaneous fat area ratio and monocyte/high-density lipoprotein ratio in patients with type 2 diabetes mellitus and albuminuria
Haiyan Lin, Jun Zhu, Chen Zheng, Xiaoming Xu, Shandong Ye
Journal of Diabetes and its Complications.2023; 37(11): 108521. CrossRef
Effects of the abdominal fat distribution on the relationship between exposure to air pollutants and thyroid hormones among Korean adult males
Hyun-Jin Kim, Byungmi Kim, Seyoung Kim, Hyuktae Kwon, Jae Moon Yun, Belong Cho, Jin-Ho Park
European Journal of Medical Research.2023;[Epub] CrossRef
Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
Clinical and Molecular Hepatology.2023; 29(4): 987. CrossRef
Visceral adipose tissue reference data computed for GE HealthCare DXA from the National Health and Nutrition Examination Survey data set
Jonathan P. Bennett, Brandon K. Quon, Bo Fan, En Liu, Leila Kazemi, Rosa C. Villegas‐Valle, Raj Ahgun, Xian‐pin Wu, Hou‐De Zhou, Ying Lu, John A. Shepherd
Obesity.2023; 31(12): 2947. CrossRef
Comparison of bioelectrical body and visceral fat indices and anthropometric measures in relation to type 2 diabetes by sex among Chinese adults, a cross-sectional study
Jiangshan He, Binbin Zhang, Yaqi Fan, Yuxue Wang, Mianzhi Zhang, Chunjun Li, Li Zhang, Pei Guo, Minying Zhang
Frontiers in Public Health.2023;[Epub] CrossRef
The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics
Jiajun Qiu, Maobin Kuang, Yang Zou, Ruijuan Yang, Qing Shangguan, Dingyang Liu, Guotai Sheng, Wei Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
Ren Jie Phang, Rebecca H. Ritchie, Derek J. Hausenloy, Jarmon G. Lees, Shiang Y. Lim
Cardiovascular Research.2022;[Epub] CrossRef
Implication of Sex Differences in Visceral Fat for the Assessment of Incidence Risk of Type 2 Diabetes Mellitus
Sang Hyeon Ju, Hyon-Seung Yi
Diabetes & Metabolism Journal.2022; 46(3): 414. CrossRef
Visceral fat area and body fat percentage measured by bioelectrical impedance analysis correlate with glycometabolism
Shuying Li, Shaoping Li, Jie Ding, Weihong Zhou
BMC Endocrine Disorders.2022;[Epub] CrossRef
The Demographic Specific Abdominal Fat Composition and Distribution Trends in US Adults from 2011 to 2018
Furong Xu, Jacob E. Earp, Bryan J. Blissmer, Ingrid E. Lofgren, Matthew J. Delmonico, Geoffrey W. Greene
International Journal of Environmental Research and Public Health.2022; 19(19): 12103. CrossRef
Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat
Ji Yeon Seo, Yoo Min Han, Su Jin Chung, Seon Hee Lim, Jung Ho Bae, Goh Eun Chung
Cancers.2022; 14(21): 5256. CrossRef
Recent Advances in Visceral Obesity and Related Diseases
佳佳魏
Advances in Clinical Medicine.2022; 12(12): 11686. CrossRef
Gender differences in the ideal cutoffs of visceral fat area for predicting MAFLD in China
Pingping Yu, Huachao Yang, Xiaoya Qi, Ruixue Bai, Shouqin Zhang, Jianping Gong, Ying Mei, Peng Hu
Lipids in Health and Disease.2022;[Epub] CrossRef

Metabolic Risk/Epidemiology
Intra-Abdominal Fat and High Density Lipoprotein Cholesterol Are Associated in a Non-Linear Pattern in Japanese-Americans: Sun Ok Song, You-Cheol Hwang, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko; Diabetes Metab J. 2020;44(2):277-285. Published online March 10, 2020; DOI: https://doi.org/10.4093/dmj.2019.0008

4,671 View
63 Download
3 Web of Science
4 Crossref

Abstract PDF PubReader

Background

We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots.

Methods

We examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal subcutaneous (SCF), and thigh fat (TF) areas in 641 Japanese-American men and women. IAF, SCF, and TF were measured by CT at the level of the umbilicus and mid-thigh. The associations between fat area measurements and HDL-C were examined using multivariate linear regression analysis adjusting for age, sex, diabetes family history, homeostasis model assessment of insulin resistance (HOMA-IR), and body mass index (BMI). Non-linearity was assessed using fractional polynomials.

Results

Mean±standard deviation of HDL-C concentration and IAF in men and women were 1.30±0.34 mg/dL, 105±55.3 cm², and 1.67±0.43 mg/dL, 74.4±46.6 cm² and differed significantly by gender for both comparisons (P<0.001). In univariate analysis, HDL-C concentration was significantly associated with CT-measured fat depots. In multivariate analysis, IAF was significantly and non-linearly associated with HDL-C concentration adjusted for age, sex, BMI, HOMA-IR, SCF, and TF (IAF: β=−0.1012, P<0.001; IAF²: β=0.0008, P<0.001). SCF was also negatively and linearly associated with HDL-C (β=−0.4919, P=0.001).

Conclusion

HDL-C does not linearly decline with increasing IAF in Japanese-Americans. A more complex pattern better fits this association.

Citations

Citations to this article as recorded by

Associations of Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Trunk Fat Mass and Visceral Fat Accumulation
Yansu Wang, Yiting Xu, Tingting Hu, Yunfeng Xiao, Yufei Wang, Xiaojing Ma, Haoyong Yu, Yuqian Bao
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 121. CrossRef
Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake
Urszula Miksza, Edyta Adamska-Patruno, Witold Bauer, Joanna Fiedorczuk, Przemyslaw Czajkowski, Monika Moroz, Krzysztof Drygalski, Andrzej Ustymowicz, Elwira Tomkiewicz, Maria Gorska, Adam Kretowski
Scientific Reports.2023;[Epub] CrossRef
Computed tomography-based investigation of the correlation of abdominal fat areas with metabolic syndrome
Kai-Yuan Cheng, Tsung-Hsien Yen, Jay Wu, Pei-Hsuan Li, Tian-Yu Shih
Journal of Radiological Science.2023; 48(1): 15. CrossRef
Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
Sun Ok Song, You-Cheol Hwang, Han Uk Ryu, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
Endocrinology and Metabolism.2021; 36(4): 835. CrossRef

Obesity and Metabolic Syndrome
Association between Blood Mercury Level and Visceral Adiposity in Adults: Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim; Diabetes Metab J. 2017;41(2):113-120. Published online December 21, 2016; DOI: https://doi.org/10.4093/dmj.2017.41.2.113

4,858 View
46 Download
38 Web of Science
39 Crossref

Abstract PDF PubReader

Background

Few studies have examined the association between mercury exposure and obesity. The aim of this study is to investigate the association between blood mercury concentrations and indices of obesity in adults.

Methods

A total of 200 healthy subjects, aged 30 to 64 years, who had no history of cardiovascular or malignant disease, were examined. Anthropometric and various biochemical profiles were measured. Visceral adipose tissue (VAT) was measured using dual-energy X-ray absorptiometry (DXA).

Results

All subjects were divided into three groups according to blood mercury concentrations. Compared with the subjects in the lowest tertile of mercury, those in the highest tertile were more likely to be male; were current alcohol drinkers and smokers; had a higher body mass index (BMI), waist circumference (WC), and VAT; had higher levels of blood pressure, fasting glucose, and insulin resistance; and consumed more fish. The blood mercury concentration was significantly associated with anthropometric parameters, showing relationships with BMI, WC, and VAT. After adjusting for multiple risk factors, the odds ratios (ORs) for high mercury concentration was significantly higher in the highest VAT tertile than in the lowest VAT tertile (OR, 2.66; 95% confidence interval, 1.05 to 6.62; P<0.05).

Conclusion

The blood mercury concentration was significantly associated with VAT in healthy adults. Further studies are warranted to confirm our findings.

Citations

Citations to this article as recorded by

Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults
Gaojie Fan, Qing Liu, Mingyang Wu, Jianing Bi, Xiya Qin, Qing Fang, Zhengce Wan, Yongman Lv, Youjie Wang, Lulu Song
Biological Trace Element Research.2023; 201(8): 3697. CrossRef
Methylmercury drives lipid droplet formation and adipokine expression during the late stages of adipocyte differentiation in 3T3-L1 cells
Yasukazu Takanezawa, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono
Toxicology.2023; 486: 153446. CrossRef
Expression Profiling of Adipogenic and Anti-Adipogenic MicroRNA Sequences following Methylmercury Exposure in Caenorhabditis elegans
Giancarlo Garofalo, Tyson Nielsen, Samuel Caito
Toxics.2023; 11(11): 934. CrossRef
Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
Food Risk Assess Europe.2023;[Epub] CrossRef
Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
Environmental Research.2022; 204: 111888. CrossRef
The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age
Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
Biological Trace Element Research.2022; 200(8): 3554. CrossRef
MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans
Tyson Nielsen, Nicole Crawford, Megan Martell, Belal Khalil, Farooq Imtiaz, Jennifer L. Newell-Caito, Samuel Caito
Chemical Research in Toxicology.2022; 35(1): 77. CrossRef
Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population
Héctor Hernández-Mendoza, Héctor Edmundo Álvarez-Loredo, Elizabeth Teresita Romero-Guzmán, Darío Gaytán-Hernández, Consuelo Chang-Rueda, Israel Martínez-Navarro, Bertha Irene Juárez-Flores, María Judith Rios-Lugo
Biological Trace Element Research.2022; 200(12): 4916. CrossRef
Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review
Yang Zhou, Frank Peprah Addai, Xinshuang Zhang, Yuelin Liu, Yinfeng Wang, Feng Lin, Alex Tuffour, Jie Gu, Guangxiang Liu, Haifeng Shi
Environmental Chemistry Letters.2022; 20(3): 1611. CrossRef
Differential fat accumulation in early adulthood according to adolescent‐BMI and heavy metal exposure
Larissa Betanzos‐Robledo, Martha M. Téllez‐Rojo, Hector Lamadrid‐Figueroa, Ernesto Roldan‐Valadez, Karen E. Peterson, Erica C. Jansen, Nil Basu, Alejandra Cantoral
New Directions for Child and Adolescent Development.2022; 2022(181-182): 37. CrossRef
The Association of Mercury and ALT with Obesity in Korean Adults: Using Data from the Korea National Health and Nutrition Examination Survey for 11 Years (KNHANES 2005, 2008~2017)
Sang Shin Pyo
Korean Journal of Clinical Laboratory Science.2022; 54(3): 192. CrossRef
Plasma titanium level is positively associated with metabolic syndrome: A survey in China’s heavy metal polluted regions
Miao Huang, Jingyuan Chen, Guangyu Yan, Yiping Yang, Dan Luo, Xiang Chen, Meian He, Hong Yuan, Zhijun Huang, Yao Lu
Ecotoxicology and Environmental Safety.2021; 208: 111435. CrossRef
Relationship Between Elevated Hair Mercury Levels, Essential Element Status, and Metabolic Profile in Overweight and Obese Adults
Anatoly V. Skalny, Jung-Su Chang, Igor P. Bobrovnitsky, Philippe Yu Kopylov, Margarita G. Skalnaya, Shih-Yi Huang, Monica Maria Bastos Paoliello, Ekaterina S. Ivanova, Weu Wang, Alexey A. Tinkov
Biological Trace Element Research.2021; 199(8): 2874. CrossRef
Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis
Ping Xu, Aiping Liu, Fengna Li, Alexey A. Tinkov, Longjian Liu, Ji-Chang Zhou
Environmental Pollution.2021; 273: 116480. CrossRef
Cadmium, lead and mercury in the blood of psoriatic and vitiligo patients and their possible associations with dietary habits
Marta Wacewicz-Muczyńska, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Maria H. Borawska
Science of The Total Environment.2021; 757: 143967. CrossRef
Crude oil and public health issues in Niger Delta, Nigeria: Much ado about the inevitable
Orish Ebere Orisakwe
Environmental Research.2021; 194: 110725. CrossRef
Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
Scientific Reports.2021;[Epub] CrossRef
Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China
Qi Zhong, Qi-rong Qin, Wan-jun Yang, Jia-liu He, Jin-liang Zhu, Zhen-yu Zhu, Fen Huang
Environmental Pollution.2021; 285: 117150. CrossRef
Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014
Yun-Jung Yang, Eun-Jung Yang, Kyongjin Park, Subin Oh, Taehyen Kim, Yeon-Pyo Hong
International Journal of Environmental Research and Public Health.2021; 18(12): 6412. CrossRef
Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease
Anatoly V. Skalny, Philippe Yu Kopylov, Monica M. B. Paoliello, Jung-Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.-J. Chao, Jan Aaseth, Sergei N. Chebotarev, Alexey A. Tinkov
International Journal of Environmental Research and Public Health.2021; 18(15): 8195. CrossRef
Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice
Cássia R. Roque, Letícia R. Sampaio, Mayumi N. Ito, Daniel V. Pinto, Juan S.R. Caminha, Paulo I.G. Nunes, Ramon S. Raposo, Flávia A. Santos, Cláudia C. Windmöller, Maria Elena Crespo-Lopez, Jacqueline I. Alvarez-Leite, Reinaldo B. Oriá, Ronald F. Pinheiro
Toxicology.2021; 464: 152992. CrossRef
Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent
Nicole Crawford, Megan Martell, Tyson Nielsen, Belal Khalil, Farooq Imtiaz, Etienne Nguidjo, Jennifer Newell-Caito, Julia Bornhorst, Tanja Schwerdtle, Samuel Caito
Toxics.2021; 9(11): 287. CrossRef
Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
Manal Abudawood, Hajera Tabassum, Atheer H. Alanazi, Fatmah Almusallam, Feda Aljaser, Mir Naiman Ali, Naif D. Alenzi, Samyah T. Alanazi, Manal A. Alghamdi, Ghadah H. Altoum, Manar A. Alzeer, Majed O. Alotaibi, Arwa Abudawood, Hazem K. Ghneim, Lulu Abdulla
Scientific Reports.2021;[Epub] CrossRef
Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Ratio in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey
Ky Young Cho
Children.2021; 8(12): 1087. CrossRef
The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Journal of Trace Elements in Medicine and Biology.2020; 62: 126601. CrossRef
Elevated blood mercury level has a non-linear association with infertility in U.S. women: Data from the NHANES 2013–2016
Fangfang Zhu, Chi Chen, Yingxuan Zhang, Si Chen, Xian Huang, Jingwei Li, Yanxi Wang, Xiaorong Liu, Gaopi Deng, Jie Gao
Reproductive Toxicology.2020; 91: 53. CrossRef
Methylmercury Induces Metabolic Alterations in Caenorhabditis elegans: Role for C/EBP Transcription Factor
Samuel W Caito, Jennifer Newell-Caito, Megan Martell, Nicole Crawford, Michael Aschner
Toxicological Sciences.2020; 174(1): 112. CrossRef
Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children
Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara He
JAMA Network Open.2020; 3(3): e201007. CrossRef
Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause
Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
Frontiers in Endocrinology.2019;[Epub] CrossRef
Mercury leads to features of polycystic ovary syndrome in rats
Eduardo Merlo, Ingridy R.G. Schereider, Maylla R. Simões, Dalton V. Vassallo, Jones B. Graceli
Toxicology Letters.2019; 312: 45. CrossRef
In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status
Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng, Xiaobin Wang
BMC Medicine.2019;[Epub] CrossRef
Mercury Is Taken Up Selectively by Cells Involved in Joint, Bone, and Connective Tissue Disorders
Roger Pamphlett, Stephen Kum Jew
Frontiers in Medicine.2019;[Epub] CrossRef
Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
Yonsei Medical Journal.2019; 60(8): 804. CrossRef
Chronic mercury at low doses impairs white adipose tissue plasticity
Danize Aparecida Rizzetti, Patricia Corrales, Janaina Trindade Piagette, José Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Toxicology.2019; 418: 41. CrossRef
Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
Xin Wang, Bhramar Mukherjee, Sung Kyun Park
Environment International.2018; 121: 683. CrossRef
Blood mercury concentration in relation to metabolic and weight phenotypes using the KNHANES 2011–2013 data
Kayoung Lee
International Archives of Occupational and Environmental Health.2018; 91(2): 185. CrossRef
The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013
Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim
Korean Journal of Pediatrics.2018; 61(4): 121. CrossRef
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Antonio Planchart, Adrian Green, Cathrine Hoyo, Carolyn J. Mattingly
Current Environmental Health Reports.2018; 5(1): 110. CrossRef
Association between Blood Mercury Level and Visceral Adiposity in Adults
Seong-Su Moon
Diabetes & Metabolism Journal.2017; 41(2): 96. CrossRef

The Role of Skeletal Muscle in Development of Nonalcoholic Fatty Liver Disease: Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee; Diabetes Metab J. 2013;37(4):278-285. Published online August 14, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.4.278

4,647 View
49 Download
58 Crossref

Abstract PDF PubReader

Background

Nonalcoholic fatty liver disease (NAFLD) is closely correlated with abnormal accumulation of visceral fat, but the role of skeletal muscle remains unclear. The aim of this study was to elucidate the role of skeletal muscle in development of NAFLD.

Methods

Among 11,116 subjects (6,242 males), we examined the effects of skeletal muscle mass and visceral fat area (VFA, by bioelectric impedance analysis) on NAFLD using by the fatty liver index (FLI).

Results

Of the total subjects (9,565 total, 5,293 males) included, 1,848 were classified as having NALFD (FLI ≥60). Body mass index, lipid profile, fasting plasma glucose, hemoglobin A1c, prevalence of type 2 diabetes (DM), hypertension (HTN), and metabolic syndrome were higher in males than females, but FLI showed no significant difference. The low FLI group showed the lowest VFA and highest skeletal muscle mass of all the groups. Skeletal muscle to visceral fat ratio (SVR) and skeletal muscle index had inverse correlations with FLI, when adjusted for age and gender. In multivariate regression analysis, SVR was negatively associated with FLI. Among SVR quartiles, the highest quartile showed very low risk of NAFLD when adjusted for age, gender, lipid profile, DM, HTN, and high sensitivity C-reactive protein from the lowest quartiles (odds ratio, 0.037; 95% confidence interval, 0.029 to 0.049).

Conclusion

Skeletal muscle mass was inversely associated with visceral fat area, and higher skeletal muscle mass may have a beneficial effect in preventing NAFLD. These results suggest that further studies are needed to ameliorate or slow the progression of sarcopenia.

Citations

Citations to this article as recorded by

Effects of nonalcoholic fatty liver disease on sarcopenia: evidence from genetic methods
Jiaqin Yuan, Jinglin Zhang, Qiang Luo, Lipeng Peng
Scientific Reports.2024;[Epub] CrossRef
Influence of Sugar-Sweetened Beverages Intake on Sarcopenic Obesity, Visceral Obesity, and Sarcopenia in Lebanese Patients with MASLD: A Case-Control Study
Maha Hoteit, Myriam Dagher, Nikolaos Tzenios, Najat Al Kaaki, Ghadir Rkein, Abdul Rahman Chahine, Yonna Sacre, Samer Hotayt, Rami Matar, Mahmoud Hallal, Micheal Maitar, Bilal Hotayt
Healthcare.2024; 12(5): 591. CrossRef
Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population
Chenbing Liu, Nan Li, Di Sheng, Yahong Shao, Lihong Qiu, Chao Shen, Zhong Liu
Lipids in Health and Disease.2024;[Epub] CrossRef
Using hyperhomocysteinemia and body composition to predict the risk of non-alcoholic fatty liver disease in healthcare workers
Xiaoyan Hao, Honghai He, Liyuan Tao, Peng Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Diagnostic Criteria and Prognostic Relevance of Sarcopenia in Patients with Inflammatory Bowel Disease—A Systematic Review
Claudia-Gabriela Potcovaru, Petruța Violeta Filip, Oana-Maria Neagu, Laura Sorina Diaconu, Teodor Salmen, Delia Cinteză, Anca Pantea Stoian, Florin Bobirca, Mihai Berteanu, Corina Pop
Journal of Clinical Medicine.2023; 12(14): 4713. CrossRef
Association between Muscle Mass Deficits and Metabolic Dysfunction-Associated Fatty Liver Disease in Adults with Body Mass Index Less than 23 kg/m2
Mi Young Lee, Hee Jeong Choi, Han Jin Oh
Korean Journal of Family Practice.2023; 13(3): 171. CrossRef
Sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio and non-alcoholic steatohepatitis in patients with biopsy-proven non-alcoholic fatty liver disease
Gang Li, Rafael S. Rios, Xin-Xin Wang, Yue Yu, Kenneth I. Zheng, Ou-Yang Huang, Liang-Jie Tang, Hong-Lei Ma, Yi Jin, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng
British Journal of Nutrition.2022; 127(11): 1613. CrossRef
2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Zi Hui Wan, Natasha Sook Yee Tang, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui,
Clinical Gastroenterology and Hepatology.2022; 20(12): 2809. CrossRef
Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies
Annalisa Cespiati, Marica Meroni, Rosa Lombardi, Giovanna Oberti, Paola Dongiovanni, Anna Ludovica Fracanzani
Biomedicines.2022; 10(1): 182. CrossRef
Impact of Sarcopenia on the Severity of the Liver Damage in Patients With Non-alcoholic Fatty Liver Disease
Vittoria Zambon Azevedo, Cristina Alina Silaghi, Thomas Maurel, Horatiu Silaghi, Vlad Ratziu, Raluca Pais
Frontiers in Nutrition.2022;[Epub] CrossRef
Fatty Liver Index and Skeletal Muscle Density
Julie A. Pasco, Sophia X. Sui, Emma C. West, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Natalie K. Hyde, Lana J. Williams, Zoe S. J. Liu, Mark A. Kotowicz
Calcified Tissue International.2022; 110(6): 649. CrossRef
Skeletal muscle mass to visceral fat area ratio as a predictor of NAFLD in lean and overweight men and women with effect modification by sex
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Hyun‐Suk Jung, Chan‐won Kim, Hyungseok Oh, Mi Kyung Kim, Won Sohn, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne
Hepatology Communications.2022; 6(9): 2238. CrossRef
Association of Low Skeletal Muscle Mass with the Phenotype of Lean Non-Alcoholic Fatty Liver Disease
Jun-Hyeon Byeon, Min-Kyu Kang, Min-Cheol Kim
Healthcare.2022; 10(5): 850. CrossRef
Muscle strength, but not body mass index, is associated with mortality in patients with non‐alcoholic fatty liver disease
Phunchai Charatcharoenwitthaya, Khemajira Karaketklang, Wichai Aekplakorn
Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2393. CrossRef
Effect of progressive resistance training with weight loss compared with weight loss alone on the fatty liver index in older adults with type 2 diabetes: secondary analysis of a 12-month randomized controlled trial
Christine L Freer, Elena S George, Sze-Yen Tan, Gavin Abbott, David W Dunstan, Robin M Daly
BMJ Open Diabetes Research & Care.2022; 10(5): e002950. CrossRef
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis
Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
Journal of Clinical Investigation.2021;[Epub] CrossRef
“Bioelectrical impedance analysis in managing sarcopenic obesity in NAFLD”
David J. Hanna, Scott T. Jamieson, Christine S. Lee, Christopher A. Pluskota, Nicole J. Bressler, Peter N. Benotti, Sandeep Khurana, David D. K. Rolston, Christopher D. Still
Obesity Science & Practice.2021; 7(5): 629. CrossRef
Decreased Muscle-to-Fat Mass Ratio Is Associated with Low Muscular Fitness and High Alanine Aminotransferase in Children and Adolescent Boys in Organized Sports Clubs
Kai Ushio, Yukio Mikami, Hiromune Obayashi, Hironori Fujishita, Kouki Fukuhara, Tetsuhiko Sakamitsu, Kazuhiko Hirata, Yasunari Ikuta, Hiroaki Kimura, Nobuo Adachi
Journal of Clinical Medicine.2021; 10(11): 2272. CrossRef
Association of Skeletal Muscle and Adipose Tissue Distribution with Histologic Severity of Non-Alcoholic Fatty Liver
Min-Kyu Kang, Jung-Hun Baek, Young-Oh Kweon, Won-Young Tak, Se-Young Jang, Yu-Rim Lee, Keun Hur, Gyeonghwa Kim, Hye-Won Lee, Man-Hoon Han, Joon-Hyuk Choi, Soo-Young Park, Jung-Gil Park
Diagnostics.2021; 11(6): 1061. CrossRef
Association of Body Composition and Sarcopenia with NASH in Obese Patients
Sophia Marie-Therese Schmitz, Lena Schooren, Andreas Kroh, Alexander Koch, Christine Stier, Ulf Peter Neumann, Tom Florian Ulmer, Patrick Hamid Alizai
Journal of Clinical Medicine.2021; 10(15): 3445. CrossRef
Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation
Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A.M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung
Molecular and Cellular Endocrinology.2021; 538: 111464. CrossRef
Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk
Kenneth Pasmans, Michiel E. Adriaens, Peter Olinga, Ramon Langen, Sander S. Rensen, Frank G. Schaap, Steven W. M. Olde Damink, Florian Caiment, Luc J. C. van Loon, Ellen E. Blaak, Ruth C. R. Meex
Frontiers in Endocrinology.2021;[Epub] CrossRef
Muscle mass and cellular membrane integrity assessment in patients with nonalcoholic fatty liver disease
Iasmin dos Santos Barreto, Raquel Oliveira dos Santos, Raquel Rocha, Claudineia de Souza, Naiade Almeida, Luiza Valois Vieira, Rafael Leiróz, Manoel Sarno, Carla Daltro, Helma Pinchemel Cotrim
Revista da Associação Médica Brasileira.2021; 67(9): 1233. CrossRef
A significant association of non-obese non-alcoholic fatty liver disease with sarcopenic obesity
Kazuhiro Kashiwagi, Michiyo Takayama, Kayoko Fukuhara, Ryoko Shimizu-Hirota, Po-Sung Chu, Nobuhiro Nakamoto, Nagamu Inoue, Yasushi Iwao, Takanori Kanai
Clinical Nutrition ESPEN.2020; 38: 86. CrossRef
Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats
BoYoon Chang, Dae Sung Kim, SungYeon Kim
Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1. CrossRef
Sarcopenia is associated with non-alcoholic fatty liver disease in men with type 2 diabetes
D.H. Seo, Y.-h. Lee, S.W. Park, Y.J. Choi, B.W. Huh, E. Lee, K.B. Huh, S.H. Kim, B.-S. Cha
Diabetes & Metabolism.2020; 46(5): 362. CrossRef
Nonalcoholic fatty liver disease and sarcopenia: pathophysiological connections and therapeutic implications
Tiziana Fernández-Mincone, Felipe Contreras-Briceño, Maximiliano Espinosa-Ramírez, Patricio García-Valdés, Antonio López-Fuenzalida, Arnoldo Riquelme, Juan Pablo Arab, Daniel Cabrera, Marco Arrese, Francisco Barrera
Expert Review of Gastroenterology & Hepatology.2020; 14(12): 1141. CrossRef
Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
Min Kyu Kang, Jung Gil Park, Min Cheol Kim
Yonsei Medical Journal.2020; 61(10): 860. CrossRef
Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
Hwi Young Kim, Su Jung Baik, Hye Ah Lee, Byoung Kwon Lee, Hye Sun Lee, Tae Hun Kim, Kwon Yoo
Scientific Reports.2020;[Epub] CrossRef
Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice
Myung-Sook Choi, Ji-Young Choi, Eun-Young Kwon
Journal of Medicinal Food.2020; 23(10): 1019. CrossRef
Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis
Changzhou Cai, Xin Song, Yishu Chen, Xueyang Chen, Chaohui Yu
Hepatology International.2020; 14(1): 115. CrossRef
Sarcopenia Is a New Risk Factor of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease
Min Kyu Kang, Kyeong Ok Kim, Min Cheol Kim, Jung Gil Park, Byung Ik Jang
Digestive Diseases.2020; 38(6): 507. CrossRef
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women
Yajie Zhang, Dajiang Lu, Renwei Wang, Weijie Fu, Shengnian Zhang
Medicina.2019; 55(10): 629. CrossRef
Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study
Beom-Jun Kim, Seong Hee Ahn, Seung Hun Lee, Seongbin Hong, Mark W. Hamrick, Carlos M. Isales, Jung-Min Koh
Aging.2019; 11(13): 4547. CrossRef
Nonalcoholic Fatty Liver Disease in Nonobese Subjects of African Origin Has Atypical Metabolic Characteristics
Debbie S Thompson, Ingrid A Tennant, Deanne P Soares, Clive Osmond, Chris D Byrne, Terrence E Forrester, Michael S Boyne
Journal of the Endocrine Society.2019; 3(11): 2051. CrossRef
Sarcopenia in patients with non‐alcoholic fatty liver disease: is it a clinically significant entity?
C. H. De Fré, M. A. De Fré, W. J. Kwanten, B. J. Op de Beeck, L. F. Van Gaal, S. M. Francque
Obesity Reviews.2019; 20(2): 353. CrossRef
Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution
Louise Johanna Maria Alferink, Katerina Trajanoska, Nicole Stephanie Erler, Josje Dorothea Schoufour, Robert Jacobus de Knegt, M. Arfan Ikram, Harry Leonardus Antonius Janssen, Oscar H. Franco, Herold J. Metselaar, Fernando Rivadeneira, Sarwa Darwish Mura
Journal of Bone and Mineral Research.2019; 34(7): 1254. CrossRef
Sarcopenia Is Significantly Associated with Presence and Severity of Nonalcoholic Fatty Liver Disease
Goh Eun Chung, Min Joo Kim, Jeong Yoon Yim, Joo Sung Kim, Ji Won Yoon
Journal of Obesity & Metabolic Syndrome.2019; 28(2): 129. CrossRef
Association of low skeletal muscle mass with advanced liver fibrosis in patients with non‐alcoholic fatty liver disease
Min Kyu Kang, Jung Gil Park, Heon Ju Lee, Min Cheol Kim
Journal of Gastroenterology and Hepatology.2019; 34(9): 1633. CrossRef
Whole‐body vibration for patients with nonalcoholic fatty liver disease: a 6‐month prospective study
Sechang Oh, Natsumi Oshida, Noriko Someya, Tsuyoshi Maruyama, Tomonori Isobe, Yoshikazu Okamoto, Taeho Kim, Bokun Kim, Junichi Shoda
Physiological Reports.2019; 7(9): e14062. CrossRef
L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice
Tomonori SATO, Nao MURAMATSU, Yoshiaki ITO, Yoshio YAMAMOTO, Takashi NAGASAWA
Journal of Nutritional Science and Vitaminology.2018; 64(3): 192. CrossRef
Short-term treatment with metformin reduces hepatic lipid accumulation but induces liver inflammation in obese mice
Alexandre Abilio de Souza Teixeira, Camila O. Souza, Luana A. Biondo, Loreana Sanches Silveira, Edson A. Lima, Helena A. Batatinha, Adriane Pereira Araujo, Michele Joana Alves, Sandro Massao Hirabara, Rui Curi, José Cesar Rosa Neto
Inflammopharmacology.2018; 26(4): 1103. CrossRef
Vitamin D and Related Deficiencies, Sarcopenia and Visceral Obesity in Obese People with NAFLD
Mihaela Petrova
Gastroenterology & Hepatology: Open Access.2018;[Epub] CrossRef
Grip Strength Moderates the Association between Anthropometric and Body Composition Indicators and Liver Fat in Youth with an Excess of Adiposity
Robinson Ramírez-Vélez, Mikel Izquierdo, Jorge Correa-Bautista, Alejandra Tordecilla-Sanders, María Correa-Rodríguez, Jacqueline Schmidt Rio-Valle, Emilio González-Jiménez, Katherine González-Ruíz
Journal of Clinical Medicine.2018; 7(10): 347. CrossRef
Longitudinal Changes in Muscle Mass and Strength, and Bone Mass in Older Adults: Gender-Specific Associations Between Muscle and Bone Losses
Kyoung Min Kim, Soo Lim, Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang
The Journals of Gerontology: Series A.2018; 73(8): 1062. CrossRef
Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle
Eleonora Poggiogalle, Lorenzo Maria Donini, Andrea Lenzi, Claudio Chiesa, Lucia Pacifico
World Journal of Gastroenterology.2017; 23(10): 1747. CrossRef
Sarcopenia and non-alcoholic fatty liver disease: Is there a relationship? A systematic review
Cristiane V Tovo, Sabrina A Fernandes, Caroline Buss, Angelo A de Mattos
World Journal of Hepatology.2017; 9(6): 326. CrossRef
Multiple molecular targets in the liver, adipose tissue and skeletal muscle in ginger-elicited amelioration of nonalcoholic fatty liver disease
Chunxia Wang, Robert Batey, Johji Yamahara, Yuhao Li
Journal of Functional Foods.2017; 36: 43. CrossRef
Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thu, Nana Takao, Hiromi Tsutsumi, Yutaka Kimura
Diabetes & Metabolism Journal.2016; 40(2): 147. CrossRef
Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects
Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Andrea Lenzi, Lorenzo Maria Donini, Rasheed Ahmad
PLOS ONE.2016; 11(1): e0145811. CrossRef
The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes
Yoshitaka Hashimoto, Takafumi Osaka, Takuya Fukuda, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
Endocrine Journal.2016; 63(10): 877. CrossRef
Sarcopenia and the cardiometabolic syndrome: A narrative review
G. Bahat, B. İlhan
European Geriatric Medicine.2016; 7(3): 220. CrossRef
Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey
Hee Yeon Kim, Chang Wook Kim, Chung-Hwa Park, Jong Young Choi, Kyungdo Han, Anwar T Merchant, Yong-Moon Park
Hepatobiliary & Pancreatic Diseases International.2016; 15(1): 39. CrossRef
Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
Sven M. Francque, Denise van der Graaff, Wilhelmus J. Kwanten
Journal of Hepatology.2016; 65(2): 425. CrossRef
Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia
Kyoung Min Kim, Hak Chul Jang, Soo Lim
The Korean Journal of Internal Medicine.2016; 31(4): 643. CrossRef
Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population
Ge Meng, Hongmei Wu, Liyun Fang, Chunlei Li, Fei Yu, Qing Zhang, Li Liu, Huanmin Du, Hongbin Shi, Yang Xia, Xiaoyan Guo, Xing Liu, Xue Bao, Qian Su, Yeqing Gu, Huijun Yang, Bin Yu, Yuntang Wu, Zhong Sun, Kaijun Niu
Scientific Reports.2016;[Epub] CrossRef
Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)
Stefano Balducci, Patrizia Cardelli, Luca Pugliese, Valeria D’Errico, Jonida Haxhi, Elena Alessi, Carla Iacobini, Stefano Menini, Lucilla Bollanti, Francesco G. Conti, Antonio Nicolucci, Giuseppe Pugliese
Diabetes Research and Clinical Practice.2015; 109(2): 355. CrossRef
Sarcopenia is a risk factor for elevated aminotransferase in men independently of body mass index, dietary habits, and physical activity
Ki Deok Yoo, Dae Won Jun, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Ho Soon Choi
Digestive and Liver Disease.2015; 47(4): 303. CrossRef

Influence of Visceral Adiposity on Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus: Eun-Hee Jang, Na-Young Kim, Yong-Moon Park, Mee-Kyoung Kim, Ki Hyun Baek, Ki-Ho Song, Kwang Woo Lee, Hyuk-Sang Kwon; Diabetes Metab J. 2012;36(4):285-292. Published online August 20, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.4.285

3,605 View
36 Download
5 Crossref

Abstract PDF PubReader

Background

The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus.

Methods

Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, and the visceral fat area was assessed using computed tomography. CAN was diagnosed using a cardiovascular reflex test. We analyzed the correlation between the visceral fat area and each parameter in this test.

Results

The mean age, body mass index (BMI), and duration of diabetes of the study population were 60±14 years (mean±standard deviation), 25.1±4.2 kg/m², and 12.3±8.9 years, respectively. The visceral fat area showed positive correlations with age, BMI, waist circumference, and subcutaneous fat area. There was no statistically significant difference in the cardiovascular reflex test outcome between genders. Univariate linear regression analysis showed that an increased visceral fat area diminished good heart rate response to a Valsalva maneuver (R²=4.9%, P=0.013 in an unadjusted model), but only in women. This statistical association was preserved after adjusting for age and BMI (R²=9.8%, P=0.0072).

Conclusion

The results of this study suggest that visceral adiposity contributes to an autonomic imbalance to some degree, as demonstrated by the impaired cardiovascular reflex test among women with type 2 diabetes.

Citations

Citations to this article as recorded by

Excessive generalized and visceral adiposity is associated with a higher prevalence of diabetic retinopathy in Caucasian patients with type 2 diabetes
Andrea Tumminia, Agostino Milluzzo, Nunzia Carrubba, Federica Vinciguerra, Roberto Baratta, Lucia Frittitta
Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 763. CrossRef
Obesity, Metabolic Syndrome and the Risk of Microvascular Complications in Patients with Diabetes mellitus
Niki Katsiki, Panagiotis Anagnostis, Kalliopi Kotsa, Dimitrios G. Goulis, Dimitri P. Mikhailidis
Current Pharmaceutical Design.2019; 25(18): 2051. CrossRef
Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Diabetes & Metabolism Journal.2018; 42(2): 169. CrossRef
Gender differences in the perception of difficulty of self-management in patients with diabetes mellitus: a mixed-methods approach
Hideyo Tsutsui, Kyoko Nomura, Masataka Kusunoki, Tetsuya Ishiguro, Takayoshi Ohkubo, Yoshiharu Oshida
Diabetology International.2016; 7(3): 289. CrossRef
Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus
Chan-Hee Jung, Bo-Yeon Kim, Kyu-Jin Kim, Sang-Hee Jung, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
Cardiovascular Diabetology.2014;[Epub] CrossRef

ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity: Yeul Bum Park, Yun Jung Choi, So Young Park, Jong Yeon Kim, Seong Ho Kim, Dae Kyu Song, Kyu Chang Won, Yong Woon Kim; Diabetes Metab J. 2011;35(3):219-225. Published online June 30, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.3.219

3,542 View
31 Download
14 Crossref

Abstract PDF PubReader

Background

The hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (K_ATP) channels in the hypothalamic neurons. We hypothesized that a lack of glucose sensing in the hypothalamus affects the regulations of appetite and body weight.

Methods

To evaluate this hypothesis, the responses to glucose loading and high fat feeding for eight weeks were compared in Kir6.2 knock-out (KO) mice and control C57BL/6 mice, because Kir6.2 is a key component of the K_ATP channel.

Results

The hypothalamic neuropeptide Y (NPY) analyzed one hour after glucose injection was suppressed in C57BL/6 mice, but not in Kir6.2 KO mice, suggesting a blunted hypothalamic response to glucose in Kir6.2 KO mice. The hypothalamic NPY expression at a fed state was elevated in Kir6.2 KO mice and was accompanied with hyperphagia. However, the retroperitoneal fat mass was markedly decreased in Kir6.2 KO mice compared to that in C57BL/6 mice. Moreover, the body weight and visceral fat following eight weeks of high fat feeding in Kir6.2 KO mice were not significantly different from those in control diet-fed Kir6.2 KO mice, while body weight and visceral fat mass were elevated due to high fat feeding in C57BL/6 mice.

Conclusion

These results suggested that Kir6.2 KO mice showed a blunted hypothalamic response to glucose loading and elevated hypothalamic NPY expression accompanied with hyperphagia, while visceral fat mass was decreased, suggesting resistance to diet-induced obesity. Further study is needed to explain this phenomenon.

Citations

Citations to this article as recorded by

17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling
Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean-Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang
Molecular Metabolism.2020; 42: 101053. CrossRef
Brain Glucose-Sensing Mechanism and Energy Homeostasis
A. J. López-Gambero, F. Martínez, K. Salazar, M. Cifuentes, F. Nualart
Molecular Neurobiology.2019; 56(2): 769. CrossRef
The involvement of purinergic signalling in obesity
Geoffrey Burnstock, Daniela Gentile
Purinergic Signalling.2018; 14(2): 97. CrossRef
High‐fat‐diet‐induced remission of diabetes in a subset of KATP‐GOF insulin‐secretory‐deficient mice
Zihan Yan, Zeenat A. Shyr, Manuela Fortunato, Alecia Welscher, Mariana Alisio, Michael Martino, Brian N. Finck, Hannah Conway, Maria S. Remedi
Diabetes, Obesity and Metabolism.2018; 20(11): 2574. CrossRef
Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis
Yue Ma, Risheka Ratnasabapathy, Chioma Izzi‐Engbeaya, Marie‐Sophie Nguyen‐Tu, Errol Richardson, Sufyan Hussain, Ivan De Backer, Christopher Holton, Mariana Norton, Gaelle Carrat, Blanche Schwappach, Guy A. Rutter, Waljit S. Dhillo, James Gardiner
Diabetes, Obesity and Metabolism.2018; 20(9): 2246. CrossRef
Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2
Woo Young Chung, Jung Woo Han, Woon Heo, Min Goo Lee, Joo Young Kim
Molecular and Cellular Biochemistry.2018; 447(1-2): 165. CrossRef
Insights into the role of neuronal glucokinase
Ivan De Backer, Sufyan S. Hussain, Stephen R. Bloom, James V. Gardiner
American Journal of Physiology-Endocrinology and Metabolism.2016; 311(1): E42. CrossRef
Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels
Julia Illison, Lijun Tian, Heather McClafferty, Martin Werno, Luke H. Chamberlain, Veronika Leiss, Antonia Sassmann, Stefan Offermanns, Peter Ruth, Michael J. Shipston, Robert Lukowski
Diabetes.2016; 65(12): 3621. CrossRef
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes
Leslie J. Baier, Yunhua Li Muller, Maria Sara Remedi, Michael Traurig, Paolo Piaggi, Gregory Wiessner, Ke Huang, Alyssa Stacy, Sayuko Kobes, Jonathan Krakoff, Peter H. Bennett, Robert G. Nelson, William C. Knowler, Robert L. Hanson, Colin G. Nichols, Clif
Diabetes.2015; 64(12): 4322. CrossRef
Glucokinase activity in the arcuate nucleus regulates glucose intake
Syed Hussain, Errol Richardson, Yue Ma, Christopher Holton, Ivan De Backer, Niki Buckley, Waljit Dhillo, Gavin Bewick, Shuai Zhang, David Carling, Steve Bloom, James Gardiner
Journal of Clinical Investigation.2015; 125(1): 337. CrossRef
Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population
Ewan R. Pearson
Diabetes.2015; 64(12): 3993. CrossRef
Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems
Uttio Roy Chowdhury, Cindy K. Bahler, Bradley H. Holman, Peter I. Dosa, Michael P. Fautsch, Ted S Acott
PLOS ONE.2015; 10(11): e0141783. CrossRef
Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: Functions of glucose and lipid metabolism in the feed intake of chickens
Xin-Ling Fang, Xiao-Tong Zhu, Sheng-Feng Chen, Zhi-Qi Zhang, Qing-Jie Zeng, Lin Deng, Jian-Long Peng, Jian-Jian Yu, Li-Na Wang, Song-Bo Wang, Ping Gao, Qing-Yan Jiang, Gang Shu
Poultry Science.2014; 93(11): 2841. CrossRef
Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat–Fed Mice
Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Bo-Ra Kim, Jong-Keun Son, Seung-Ho Lee, Yong-Woon Kim
Journal of Medicinal Food.2013; 16(1): 2. CrossRef

First
Prev
Page of 1
Next
Last

Search