Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 29(4); 2005 > Article
Original Article Relationship of LDL Particle Size to IMT and Insulin Resistance in Non-Diabetic Adult.
Jina Park, Chul Sik Kim, Jong Suk Park, Dol Mi Kim, Min Ho Cho, Jee Hyun Kong, Hai Jin Kim, Jeong Ho Kim, Chul Woo Ahn, Kyung Rae Kim, Bong Soo Cha, Sung Kil Lim, Hyun Chul Lee
Diabetes & Metabolism Journal 2005;29(4):333-343
DOI: https://doi.org/
Published online: July 1, 2005
  • 1,059 Views
  • 17 Download
  • 0 Crossref
  • 0 Scopus
1Department of Internal Medicine, Yonsei University College of Medicine, Korea.
2Department of Internal Medicine, Hallym University College of Medicine, Korea.
3Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

BACKGROUND
The aims of this study were to investigate the predictor of the low density lipoprotein(LDL) particle size and the relationship of the LDL particle size to the levels of insulin resistance and the carotid intima-media thickness (IMT) in healthy Koreans. METHODS: The subjects were 47 and 89 clinically healthy males and females, aged between 32 and 70years, without medications that could potentially alter glucose and lipid metabolisms. The mean LDL particle size was determined by polyacrylamide tube gel electrophoresis(Lipoprint(r) LDL, Quantimetrix), the insulin resistance using a short insulin tolerance test kit, and the subclinical atherosclerosis from the carotid intima-media thickness. RESULTS: The LDL particle size was found to be significantly correlated with insulin resistance using a simple Pearson's correlation(r=0.233, P<0.01), but the independent predictors of the LDL particle size, as determined by a multiple stepwise regression analysis, were serum triglyceride(TG), high density lipoprotein(HDL) cholesterol level and age(beta=-0.403, P=< 0.001; beta=0.309, P=0.003; beta=-0.219, P=0.016, respectively). Significant relationships were found between an increasing IMT and the traditional risk factors of atherosclerosis: age, LDL cholesterol, HDL cholesterol, systolic and diastolic blood pressure(r=0.490, P<0.001; r=-0.251, P<0.01; r=0.211, P<0.05; r=0.298, P<0.01; r=0.263, P<0.01, respectively). However, no significant correlation was found between an increasing IMT and the LDL particle size (r=-0.172, P=0.075). CONCLUSION: The best predictors for the LDL particle size were the serum TG level, HDL cholesterol level and age. Insulin resistance was not found to be an independent predictor of the LDL particle size. Small dense LDL was not found to be a predictor of the IMT in healthy Koreans.

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Relationship of LDL Particle Size to IMT and Insulin Resistance in Non-Diabetic Adult.
    Korean Diabetes J. 2005;29(4):333-343.   Published online July 1, 2005
    Close
Related articles
Park J, Kim CS, Park JS, Kim DM, Cho MH, Kong JH, Kim HJ, Kim JH, Ahn CW, Kim KR, Cha BS, Lim SK, Lee HC. Relationship of LDL Particle Size to IMT and Insulin Resistance in Non-Diabetic Adult.. Diabetes Metab J. 2005;29(4):333-343.
DOI: https://doi.org/.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer