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- HOME > Diabetes Metab J > Volume 30(6); 2006 > Article
- Randomized Controlled Trial Randomized, Open Label, Multicenter Clinical Trial about the Effect of Cilazapril on Vascular Endothelial Function in Patients with Type 2 Diabetes Combined with Hypertension.
- Sang Youl Rhee, Jeong Taek Woo, Sei Hyun Baik, Hyoung Woo Lee, In Kyu Lee, Hye Soon Kim, Moon Kyu Lee, Min Ho Shong, Chung Gu Cho, Byoung Hyun Park, Bong Soo Cha, Young Seol Kim
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Diabetes & Metabolism Journal 2006;30(6):450-458
DOI: https://doi.org/10.4093/jkda.2006.30.6.450
Published online: November 1, 2006
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1Department of Endocrinology and Metabolism, Kyung Hee University, Korea.
2Department of Endocrinology and Metabolism, Korea University, Korea.
3Department of Endocrinology and Metabolism, Young Nam University, Korea.
4Department of Endocrinology and Metabolism, Kyung Pook National University, Korea.
5Department of Endocrinology and Metabolism, Keimyung University, Korea.
6Department of Endocrinology and Metabolism, Sung Kyun Kwan University, Korea.
7Department of Endocrinology and Metabolism, Choong Nam National University, Korea.
8Department of Endocrinology and Metabolism, Won Kwang University, Korea.
9Department of Endocrinology and Metabolism, Yonsei University, Korea.
2Department of Endocrinology and Metabolism, Korea University, Korea.
3Department of Endocrinology and Metabolism, Young Nam University, Korea.
4Department of Endocrinology and Metabolism, Kyung Pook National University, Korea.
5Department of Endocrinology and Metabolism, Keimyung University, Korea.
6Department of Endocrinology and Metabolism, Sung Kyun Kwan University, Korea.
7Department of Endocrinology and Metabolism, Choong Nam National University, Korea.
8Department of Endocrinology and Metabolism, Won Kwang University, Korea.
9Department of Endocrinology and Metabolism, Yonsei University, Korea.
Abstract
BACKGROUND
The angiotensin converting enzyme inhibitor (ACEi) improves the vascular endothelial cell function and has a better clinical outcome by decreasing the LDL cholesterol oxidation, hypercoagulability, oxidative stress and improving the level of endothelial nitric oxide synthesis in patients with type 2 diabetes and hypertension. However, the correlations between the ACEi and the serum markers for the vascular endothelial function in previous studies were not consistent. SUBJECTS AND METHODS: Between July 2003 and April 2005, 104 type 2 diabetes patients with hypertension, who had been admitted to 9 major university hospitals in Korea, were examined. The subjects were randomly allocated to the cilazapril (2.5~5 mg/day) and atenolol (50~100 mg/day) treatment group and given a combination of hydrochlorothiazide and amlodipine. The lipid profile and the markers for endothelial function, such as vWF, VCAM, E-selectin, tPA, fibrinogen, adiponectin, hsCRP, nitrotyrosine were evaluated and the differences in the variables were compared with those obtained 6 months later. RESULTS: A total 56 subjects completed the 6-months follow up period. Regarding the baseline characteristics, there were no significant differences in the variables observed in the two groups except for HbA1c (P = 0.037), vWF (P = 0.048), and hsCRP (P = 0.038). After 6 months, both groups showed a significant and identical decrease in the systolic and diastolic blood pressure compared with the baseline (P < 0.002). However, there were no significant differences in the endothelial markers between each group. On the other hand, there was some deterioration in the triglyceride (P = 0.009) and HbA1c (P = 0.017) levels in the atenolol treatment groups. CONCLUSIONS: There were no significant differences in the endothelial function markers observed between the cilazapril and atenolol groups. However, cilazapril had an identical effect on the blood pressure reduction compared with atenolol but had fewer adverse effects on the glucose and lipid metabolism.
Cite- Rhee SY, Woo JT, Baik SH, Lee HW, Lee IK, Kim HS, Lee MK, Shong MH, Cho CG, Park BH, Cha BS, Kim YS. Randomized, Open Label, Multicenter Clinical Trial about the Effect of Cilazapril on Vascular Endothelial Function in Patients with Type 2 Diabetes Combined with Hypertension.. Diabetes Metab J. 2006;30(6):450-458.
- DOI: https://doi.org/10.4093/jkda.2006.30.6.450.
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