1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
2Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
3National Institute of Health, Seoul, Korea.
4Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.
5Department of life science, Sogang University, Seoul, Korea.
6Department of Internal Medicine, Inje University College of Medicine, Busan, Korea.
7Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
Copyright © 2010 Korean Diabetes Association
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Data are given as means ± standard deviation for normally distributed variables, and otherwise as medians (range). BMI, body mass index; HDL-C, high density lipoprotein cholesterol. a
Genotype distributions are shown as numbers (%). Odds ratio (OR), 95% confidence interval (CI), and Type 2 diabetic patients were divided into three subgroups according to age at diagnosis. ORs are expressed per difference in number of rare alleles using an additive model after controlling for sex and body mass index (BMI). FDR, false discovery rate. a'Early onset' was defined as diabetic subjects with the age at diagnosis of 25 ≤ < 40, bAverage-onset included subjects with age at diagnosis of 40 ≤ < 60, cand age at diagnosis of ≥ 60 years was considered late-onset, dOR between control and all type 2 diabetes patients, eOR between normal controls and early-onset diabetes patients, fOR between normal controls and subjects with average- and late-onset diabetes, gFDR, adjusting for multiple comparisons in the multivariate binary regression analyses of additive effects of polymorphisms in early-onset diabetes compared to control subjects, h
Each haplotype with a frequency of > 0.05 is shown. The genotype of each haplotype is shown according to the sequence: g.-385, g.-36, g.209, g.1385, and g.2199. OR, odds ratio; CI, confidence interval. a'Early onset' was defined as the diabetic subjects with the age at diagnosis of 25 ≤ < 40, b'Other' was defined as the diabetic subjects with the age at diagnosis of 40 years or more, cOR between control and all type 2 diabetes patients after controlling for sex and body mass index (BMI) using the dominant model, dOR between normal controls and early-onset diabetes patients after controlling for sex and BMI using the dominant model, eOR between normal controls and the other diabetes patients after controlling for sex and BMI using the dominant model, f