1Research Center for Endocrine and Metabolic Diseases, Chungnam National University College of Medicine, Daejeon, Korea.
2Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Korea.
Copyright © 2020 Korean Diabetes Association
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Disease model | Organism | Organ/tissue | Findings | Reference |
---|---|---|---|---|
Cardiovascular | Mouse, human | Brain, Heart | Predictive biomarker for mortality related to stroke, myocardial infarction, cardiac ischemia, and heart failure | [1819232425] |
Cardiovascular | Rat, mouse | Heart | GDF15 protects against cardiac hypertrophy and ischemia reperfusion injury | [2021] |
Inflammation | Mouse | Macrophage | GDF15 polarizes macrophages toward anti-inflammatory M2 | [3031] |
Liver fibrosis and NASH | Mouse | Liver | Alcohol-induced fibrosis is attenuated by GDF15; GDF15 Tg mice have reduced symptoms of NASH | [6162] |
Cancer | In vitro, mouse | Lung and glioma | GDF15 induces apoptosis | [3435] |
Cancer | Various | Various | GDF15 promotes proliferation and metastasis | [32] |
Aging | Mouse, human | Serum | Increased serum GDF15 correlated with age | [3839] |
Mitochondrial dysfunction | Mouse | Various | Increased GDF15 induction and improved metabolism | [73145] |
Longevity | Mouse | Whole body | Female GDF15 Tg mice have increased lifespan | [46] |
Disease model | Organism | Organ/tissue | Findings | Reference |
---|---|---|---|---|
Cardiovascular | Mouse, human | Brain, Heart | Predictive biomarker for mortality related to stroke, myocardial infarction, cardiac ischemia, and heart failure | [ |
Cardiovascular | Rat, mouse | Heart | GDF15 protects against cardiac hypertrophy and ischemia reperfusion injury | [ |
Inflammation | Mouse | Macrophage | GDF15 polarizes macrophages toward anti-inflammatory M2 | [ |
Liver fibrosis and NASH | Mouse | Liver | Alcohol-induced fibrosis is attenuated by GDF15; GDF15 Tg mice have reduced symptoms of NASH | [ |
Cancer | In vitro, mouse | Lung and glioma | GDF15 induces apoptosis | [ |
Cancer | Various | Various | GDF15 promotes proliferation and metastasis | [ |
Aging | Mouse, human | Serum | Increased serum GDF15 correlated with age | [ |
Mitochondrial dysfunction | Mouse | Various | Increased GDF15 induction and improved metabolism | [ |
Longevity | Mouse | Whole body | Female GDF15 Tg mice have increased lifespan | [ |
GDF15, growth differentiation factor 15; NASH, nonalcoholic steatohepatitis; Tg, transgenic.