Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 43(1); 2019 > Article
Editorial
Epidemiology Concern about the Safety of Bisphenol A Substitutes
Min Kyong Moon1,2orcid
Diabetes & Metabolism Journal 2019;43(1):46-48.
DOI: https://doi.org/10.4093/dmj.2019.0027
Published online: February 19, 2019
  • 6,183 Views
  • 83 Download
  • 64 Web of Science
  • 63 Crossref
  • 67 Scopus

1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

2Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.

Corresponding author: Min Kyong Moon. Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. mkmoon@snu.ac.kr

Copyright © 2019 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bisphenol A (BPA) is a base material for the production of polycarbonate plastic and epoxy resin, and it is one of the most produced chemicals [1]. BPA is a well-known endocrine disruptor and has a weak estrogenic effect. The adverse effects of BPA are largely related to its estrogenic activity [23], and they can disturb reproductive function. In addition, recent epidemiologic evidence has also shown that BPA is implicated in cardiovascular disease, type 2 diabetes mellitus, and obesity: high serum or urine BPA levels have been positively associated with diabetes mellitus [45], cardiovascular disease [4], obesity, and insulin resistance [6]. Therefore, BPA has been regulated in many countries. BPA was banned in baby bottles in Canada in 2008, in France in 2010, and in the European Union in 2011 [7]. Such regulations have led to the development of substitutes such as bisphenol S (BPS) and bisphenol F (BPF).
These BPA substitutes-based products are consumed under the label of “BPA-free.” This term gives the impression that the products are safe, but the safety of the substitutes is not fully verified [89]. Because of structural similarities with BPA (Fig. 1), these alternatives also show endocrine disruption effects like BPA, and many studies on adverse health effects of these alternatives are being reported.
In this issue of the Diabetes and Metabolism Journal, Liu et al. [10] evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents using data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014. They found that exposure to BPF was positively associated with higher risk of obesity in children and adolescents, especially in boys. In terms of BPS, they did not observe significant associations with either general obesity or abdominal obesity. In their previous article, BPF or BPS was not significantly associated with obesity in U.S. adults [11]. BPS and BPF may have less harmful impact on health than BPA. However, as noted by the authors, since BPS or BPF has not replaced BPA for a long time, no significant results could be obtained due to their relative low exposure.
In a systematic review regarding comparison of the hormonal activity of BPA substitutes, the hormonal activities of BPS and BPF were in the same order of magnitude and of similar action as BPA (estrogenic, anti-estrogenic, androgenic, and anti-androgenic) in vitro and in vivo [9]. BPS and BPF showed altered organ weights, reproductive end points, and enzyme expression. In a recent study, the agonistic and/or antagonistic activities of BPA and its eight analogues (BPAF, BPAP, BPB, BPE, BPF, BPP, BPS, and BPZ) against human nuclear receptors (estrogen receptors [ERs], androgen receptor, glucocorticoid receptor, pregnane X receptor, and constitutive androstane receptor) were characterized via in vitro transactivation assays (Fig. 2) [12]. All the test compounds, except for BPP, showed both ERα- and ERβ-agonistic activities, with BPAF being the most potent. BPF and BPS were found to show weaker estrogenic activities than BPA. Their results suggested that BPA analogues demonstrate multiple effects via human nuclear receptors in a similar manner to BPA, and several analogues might have more potent endocrine-disrupting activity than BPA.
In Korea, BPS are used for thermal receipt papers and BPF as a water pipe coating agent instead of BPA [13]. In the study measuring the concentrations of BPA, BPS, and BPF in the rivers of Japan, Korea, China, and India, BPF was the major bisphenol in rivers and the levels exceeded those of BPA. In the Han River in Korea, median concentrations of BPA, BPS, and BPF were 144, 41, and 555 ng/L, respectively. These were much higher compared with Nakdong River or Yeongsan River, where no BPF was detected [14]. This could be associated with the use of BPF-coated water pipes in Seoul [13]. In 2012, Liao et al. [14] analyzed BPS concentrations in 315 urine samples collected from the general populations in the United States and seven Asian countries including Korea. The urinary BPS concentration in Korea was very low (0.030 ng/mL) compared with Japan (1.18 ng/mL), United States (0.299 ng/mL) or China (0.226 ng/mL). However, the results are likely to change as BPS is replacing BPA for thermal receipt papers.
Because BPA substitutes such as BPS and BPF have similar structures to BPA, they appear to have similar metabolism, potencies, and action to BPA. In addition, they may pose similar potential health hazards as BPA. Continued biomonitoring of these bisphenols in populations and thorough investigations on their health effects in humans are needed. Manufacturers should continue to seek alternative safe materials rather than merely replacing BPA with bisphenol analogs.

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

  • 1. Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, Soto AM. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 2007;148:116-127. ArticlePubMed
  • 2. Hiroi H, Tsutsumi O, Momoeda M, Takai Y, Osuga Y, Taketani Y. Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. Endocr J 1999;46:773-778. ArticlePubMed
  • 3. Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y. The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type. Endocr J 2002;49:465-471. ArticlePubMed
  • 4. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008;300:1303-1310. ArticlePubMed
  • 5. Shankar A, Teppala S. Relationship between urinary bisphenol A levels and diabetes mellitus. J Clin Endocrinol Metab 2011;96:3822-3826. ArticlePubMedPMC
  • 6. Wang T, Li M, Chen B, Xu M, Xu Y, Huang Y, Lu J, Chen Y, Wang W, Li X, Liu Y, Bi Y, Lai S, Ning G. Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 2012;97:E223-E227. ArticlePubMedPDF
  • 7. Cano-Nicolau J, Vaillant C, Pellegrini E, Charlier TD, Kah O, Coumailleau P. Estrogenic effects of several BPA analogs in the developing zebrafish brain. Front Neurosci 2016;10:112ArticlePubMedPMC
  • 8. Eladak S, Grisin T, Moison D, Guerquin MJ, N'Tumba-Byn T, Pozzi-Gaudin S, Benachi A, Livera G, Rouiller-Fabre V, Habert R. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril 2015;103:11-21. ArticlePubMed
  • 9. Rochester JR, Bolden AL. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Perspect 2015;123:643-650. ArticlePubMedPMC
  • 10. Liu B, Lehmler HJ, Sun Y, Xu G, Sun Q, Snetselaar LG, Wallace RB, Bao W. Association of bisphenol A and its substitutes, bisphenol F and bisphenol S, with obesity in United States children and adolescents. Diabetes Metab J 2019;43:59-75. ArticlePubMedPMCPDF
  • 11. Liu B, Lehmler HJ, Sun Y, Xu G, Liu Y, Zong G, Sun Q, Hu FB, Wallace RB, Bao W. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 2017;1:e114-e122. ArticlePubMedPMC
  • 12. Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K. Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology 2019;413:48-55. ArticlePubMed
  • 13. Song CY, Kim W, Gye MC. Current state of use and the risks of bisphenols: a minireview. Korean J Environ Biol 2017;35:581-594.Article
  • 14. Liao C, Liu F, Alomirah H, Loi VD, Mohd MA, Moon HB, Nakata H, Kannan K. Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures. Environ Sci Technol 2012;46:6860-6866. ArticlePubMed
Fig. 1

Chemical structures of (A) bisphenol A, (B) bisphenol S, and (C) bisphenol F.

dmj-43-46-g001.jpg
Fig. 2

Profiling of bisphenol A (BPA) and eight its analogues on transcriptional activity via human nuclear receptors. Adapted from Kojima et al. [12], with permission from Elsevier. ERα, human estrogen receptors α; ERβ, human estrogen receptors β; AR, androgen receptor; GR, glucocorticoid receptor; PXR, pregnane X receptor; CAR, constitutive androstane receptor; REC20, the concentrations of the compound equal to 20% of the maximal response of the positive control intensity; RIC20, the concentrations of the test compounds showing 20% inhibition of the activities induced by the endogenous hormones or vehicle control.

dmj-43-46-g002.jpg

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • The use of alternatives assessment in chemicals management policies: Needs for greater impact
      Catherine Rudisill, Molly Jacobs, Monika Roy, Lauren Brown, Rae Eaton, Tim Malloy, Holly Davies, Joel Tickner
      Integrated Environmental Assessment and Management.2024; 20(4): 1035.     CrossRef
    • Toxic Ingredients in Personal Care Products: A Dermatological Perspective
      Rachel R. Lin, Deborah A. Lin, Andrea D. Maderal
      Dermatitis®.2024; 35(2): 121.     CrossRef
    • Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
      Sonal Sangwan, Rajasri Bhattacharyya, Dibyajyoti Banerjee
      Liver International.2024; 44(5): 1093.     CrossRef
    • Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor
      Rajesh Kumar Pathak, Da-Woon Jung, Seung-Hee Shin, Buom-Yong Ryu, Hee-Seok Lee, Jun-Mo Kim
      Journal of Hazardous Materials.2024; 469: 133935.     CrossRef
    • Epoxidized technical Kraft lignin as a particulate resin component for high-performance anticorrosive coatings
      Alessio Truncali, Tejasvi Laxminarayan, Narayanan Rajagopalan, Claus Erik Weinell, Søren Kiil, Mats Johansson
      Journal of Coatings Technology and Research.2024;[Epub]     CrossRef
    • Bisphenol A analysis and quantification inconsistencies via HPLC-UV: a systematic review with technical notes
      Cristian-Emilian Pop, Bogdan Andrei Miu, Dávid Németh, Robert Wolff, Dan Florin Mihăilescu, Sorin Marius Avramescu, Maria Mernea
      Discover Applied Sciences.2024;[Epub]     CrossRef
    • Gene Target Prediction of Environmental Chemicals Using Coupled Matrix–Matrix Completion
      Kai Wang, Nicole Kim, Maryam Bagherian, Kai Li, Elysia Chou, Justin A. Colacino, Dana C. Dolinoy, Maureen A. Sartor
      Environmental Science & Technology.2024; 58(13): 5889.     CrossRef
    • Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system
      Melissa Dibbernn Ganzerla, Nathalia de Carvalho Indolfo, Larissa Cleres Moreira Oliveira, Tabata Renee Doratioto, Thayná Mendonça Avelino, Rafael Junior de Azevedo, Larissa Bueno Tofani, Maiara Ferreira Terra, Giovanna Blazutti Elias, Irene Layane de Sous
      Toxicology in Vitro.2024; 98: 105849.     CrossRef
    • Experimental toxicological assessment of the degree of hazard of a mixture of chemical compounds migrating from materials intended for use in drinking water supply
      Anna V. Alekseeva, Yuriy A. Rakhmanin, Rufina I. Mikhailova, Natalia A. Egorova, Ludmila V. Khripach, Valentina V. Yurchenko
      Hygiene and sanitation.2024; 103(4): 365.     CrossRef
    • Impacts associated with the plastic polymers polycarbonate, polystyrene, polyvinyl chloride, and polybutadiene across their life cycle: A review
      Bhedita J. Seewoo, Enoch V.S. Wong, Yannick R. Mulders, Louise M. Goodes, Ela Eroglu, Manuel Brunner, Aleksandra Gozt, Priyanka Toshniwal, Christos Symeonides, Sarah A. Dunlop
      Heliyon.2024; 10(12): e32912.     CrossRef
    • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
      Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
      Exposure and Health.2023; 15(1): 53.     CrossRef
    • An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products
      John N. Hahladakis, Eleni Iacovidou, Spyridoula Gerassimidou
      Integrated Environmental Assessment and Management.2023; 19(1): 45.     CrossRef
    • Bisphenol A alternatives continuously contribute to the endocrine disruption in cetaceans
      Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Jiaxue Wu, Yuping Wu
      Environment International.2023; 171: 107679.     CrossRef
    • Interactions of Bisphenol A with Artemia franciscana and the ameliorative effect of probiotics
      Despoina Giamaki, Malamati Tsiotsiou, Sevnta Chousein Oglou, Maria Touraki
      Environmental Toxicology and Pharmacology.2023; 98: 104064.     CrossRef
    • Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years
      Sarah Dee Geiger, Salma Musaad, Jennifer Hill, Andréa Aguiar, Susan Schantz
      Neurotoxicology and Teratology.2023; 96: 107152.     CrossRef
    • The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S
      Soňa Kucharíková, Patrícia Hockicková, Kamila Melnikov, Zuzana Bárdyová, Alžbeta Kaiglová
      Toxicology Reports.2023; 10: 341.     CrossRef
    • Endocrine-active and endocrine-disrupting compounds in food – occurrence, formation and relevance
      Constanze Stiefel, Florian Stintzing
      NFS Journal.2023; 31: 57.     CrossRef
    • Early Environment and Telomeres: a Long-Term Toxic Relationship
      José Francisco Herrera-Moreno, Diddier Prada, Andrea A. Baccarelli
      Current Environmental Health Reports.2023; 10(2): 112.     CrossRef
    • Bisphenol A prevents MCF‐7 breast cell apoptosis via the inhibition of progesterone receptor transactivation
      Masahiro Ogawa, Junya Kitamoto, Takeo Takeda, Megumi Terada
      Journal of Biochemical and Molecular Toxicology.2023;[Epub]     CrossRef
    • Interaction of micro(nano)plastics and bisphenols in the environment: A recent perspective on adsorption mechanisms, influencing factors and ecotoxic impacts
      Dandan Gao, Muhammad Junaid, Xikun Chen, Hongping Liao, Guanglong Chen, Jun Wang
      TrAC Trends in Analytical Chemistry.2023; 165: 117132.     CrossRef
    • Plastic ingestion by two cetacean groups: Ziphiidae and Delphinidae
      Sergio López-Martínez, Esther Giménez-Luque, Jose Luis Molina-Pardo, Sandra Manzano-Medina, Héctor Arribas-Arias, Rafael Gavara, Carmen Morales-Caselles, Marga L. Rivas
      Environmental Pollution.2023; 333: 121932.     CrossRef
    • Endocrine‐disrupting compounds and metabolomic reprogramming in breast cancer
      Cassandra Winz, Wei‐Xing Zong, Nanjoo Suh
      Journal of Biochemical and Molecular Toxicology.2023;[Epub]     CrossRef
    • Microwave‐assisted fractionation and functionalization of technical lignin toward thermoset resins
      Alessio Truncali, Iuliana Ribca, Jenevieve Yao, Minna Hakkarainen, Mats Johansson
      Journal of Applied Polymer Science.2023;[Epub]     CrossRef
    • Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling
      Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
      Frontiers in Endocrinology.2023;[Epub]     CrossRef
    • Gestational exposure to bisphenol S induces microvesicular steatosis in male rat offspring by modulating metaflammation
      Archana Molangiri, Saikanth Varma, Kota Sri Naga Hridayanka, Myadara Srinivas, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
      Science of The Total Environment.2023; 904: 166775.     CrossRef
    • The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals
      Bhedita J Seewoo, Louise M Goodes, Louise Mofflin, Yannick R Mulders, Enoch VS Wong, Priyanka Toshniwal, Manuel Brunner, Jennifer Alex, Brady Johnston, Ahmed Elagali, Aleksandra Gozt, Greg Lyle, Omrik Choudhury, Terena Solomons, Christos Symeonides, Sarah
      Environment International.2023; 181: 108225.     CrossRef
    • In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th Differentiation
      Pia Štrukelj Pahović, Martina Iulini, Ambra Maddalon, Valentina Galbiati, Erica Buoso, Marija Sollner Dolenc, Emanuela Corsini
      Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(14): 1750.     CrossRef
    • Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation
      Handule Lee, Juyoung Park, Kwangsik Park
      Toxics.2023; 11(12): 986.     CrossRef
    • Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products
      Manel Chebbi, Asma Beltifa, Sana Alibi, Giuseppa Di Bella, Vincenzo Loturco, Olivier Sire, Hedi Ben Mansour, Véronique Le Tilly
      International Journal of Environmental Health Research.2022; 32(2): 252.     CrossRef
    • Determination of contamination levels for multiple endocrine disruptors in hair from a non-occupationally exposed population living in Liege (Belgium)
      Julien Claessens, Catherine Pirard, Corinne Charlier
      Science of The Total Environment.2022; 815: 152734.     CrossRef
    • Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa
      Mimi Nguyen, Reem Sabry, Ola S. Davis, Laura A. Favetta
      Genes.2022; 13(1): 142.     CrossRef
    • Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study
      Ruth Naomi, Muhammad Dain Yazid, Hasnah Bahari, Yong Yoke Keong, Retnagowri Rajandram, Hashim Embong, Soo Huat Teoh, Shariff Halim, Fezah Othman
      International Journal of Molecular Sciences.2022; 23(6): 2969.     CrossRef
    • The Importance of Addressing Early-Life Environmental Exposures in Cancer Epidemiology
      Nicole M. Niehoff, Mandy Goldberg, Alexandra J. White
      Current Epidemiology Reports.2022; 9(2): 49.     CrossRef
    • Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis
      Hong-Mei Li, Yuan-Yuan Li, Ying-Chi Zhang, Jin-Bo Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin
      Ecotoxicology and Environmental Safety.2022; 236: 113453.     CrossRef
    • Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F
      Somin Lee, Kyu Sup An, Hye Jin Kim, Hye Jin Noh, JaeWon Lee, Jiho Lee, Kyung Seuk Song, Chanhee Chae, Hyeon Yeol Ryu
      Archives of Toxicology.2022; 96(6): 1711.     CrossRef
    • Detection of Bisphenol A and Four Analogues in Atmospheric Emissions in Petrochemical Complexes Producing Polypropylene in South America
      Joaquín Hernández Fernández, Yoleima Guerra, Heidi Cano
      Molecules.2022; 27(15): 4832.     CrossRef
    • Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis
      Chen Huang, Yuqin Wang, Xiao Lin, Ting Fung Chan, Keng Po Lai, Rong Li
      Ecotoxicology and Environmental Safety.2022; 242: 113897.     CrossRef
    • Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study
      Mahendra K. Pant, Abul. H. Ahmad, Manisha Naithani, Jayanti Pant
      Clinical and Experimental Pediatrics.2022; 65(9): 459.     CrossRef
    • Synthesis and reproductive toxicity of bisphenol A analogs with cyclic side chains in Caenorhabditis elegans
      Andrew H Roberts, John E Bowen, Xinrui Zhou, Isabella Burke, Maxwell H Wenaas, Timothy A Blake, Shannon C Timmons, Aleksandra Kuzmanov
      Toxicology and Industrial Health.2022; 38(10): 665.     CrossRef
    • Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives
      Poonam Sharma, Reena Vishwakarma, Sunita Varjani, Krishna Gautam, Vivek K. Gaur, Alvina Farooqui, Raveendran Sindhu, Parameswaran Binod, Mukesh Kumar Awasthi, Preeti Chaturvedi, Ashok Pandey
      Environmental Research.2022; 215: 114198.     CrossRef
    • Climate change and the water quality threats posed by the emerging contaminants per- and polyfluoroalkyl substances (PFAS) and microplastics
      Malcolm J. Gander
      Water International.2022; : 1.     CrossRef
    • Bisphenol AF induces multiple behavioral and biochemical changes in zebrafish (Danio rerio) at different life stages
      Chenyang Rao, Xianglin Cao, Lulu Li, Jiameng Zhou, Dandan Sun, Baohua Li, Suqi Guo, Rongjie Yuan, Han Cui, Jianjun Chen
      Aquatic Toxicology.2022; 253: 106345.     CrossRef
    • Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
      Niyazi Emre Kurşunoğlu, Banu Pinar Sarer Yurekli
      World Journal of Clinical Cases.2022; 10(31): 11226.     CrossRef
    • Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway
      Emilia Kourmaeva, Reem Sabry, Laura A. Favetta
      Frontiers in Endocrinology.2022;[Epub]     CrossRef
    • Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology
      Maria Popescu, Talia B. Feldman, Tanuja Chitnis
      Frontiers in Pharmacology.2021;[Epub]     CrossRef
    • Determination of Bisphenol Analogues in Infant Formula Products from India and Evaluating the Health Risk in Infants Asssociated with Their Exposure
      Kajal Karsauliya, Manisha Bhateria, Ashish Sonker, Sheelendra Pratap Singh
      Journal of Agricultural and Food Chemistry.2021; 69(13): 3932.     CrossRef
    • Bisphenols' occurrence in bivalves as sentinel of environmental contamination
      Elena Baralla, Valeria Pasciu, Maria Vittoria Varoni, Maria Nieddu, Roberto Demuro, Maria Piera Demontis
      Science of The Total Environment.2021; 785: 147263.     CrossRef
    • Bisphenol A and its effects on the systemic organs of children
      Sarah Zulkifli, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir, Noor Shafina Mohd Nor
      European Journal of Pediatrics.2021; 180(10): 3111.     CrossRef
    • Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis
      Yue Niu, Min Zhu, Mengqi Dong, Jinbo Li, Yuanyuan Li, Yiming Xiong, Pengyan Liu, Zhanfen Qin
      Aquatic Toxicology.2021; 237: 105902.     CrossRef
    • Urinary Bisphenol A Concentrations and Parameters of Ovarian Reserve among Women from a Fertility Clinic
      Ewelina Czubacka, Bartosz Wielgomas, Anna Klimowska, Michał Radwan, Paweł Radwan, Anetta Karwacka, Paweł Kałużny, Joanna Jurewicz
      International Journal of Environmental Research and Public Health.2021; 18(15): 8041.     CrossRef
    • Bisphenol S and Bisphenol F Are Less Disruptive to Cardiac Electrophysiology, as Compared With Bisphenol A
      Tomas M Prudencio, Luther M Swift, Devon Guerrelli, Blake Cooper, Marissa Reilly, Nina Ciccarelli, Jiansong Sheng, Rafael Jaimes, Nikki Gillum Posnack
      Toxicological Sciences.2021; 183(1): 214.     CrossRef
    • Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation
      Hye-Min Kim, Seon-Min Lee, Jungil Choi, Nak-Kyun Soung, Jeong-Doo Heo
      Molecules.2021; 26(20): 6100.     CrossRef
    • Plastic pollution: why is it a public health problem?
      Andrew Daltry, Lea Merone, Peter Tait
      Australian and New Zealand Journal of Public Health.2021; 45(6): 535.     CrossRef
    • Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization
      Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin
      Environmental Pollution.2020; 260: 113980.     CrossRef
    • Road impact in a protected area with rich biodiversity: the case of the Sebitoli road in Kibale National Park, Uganda
      Sabrina Krief, Alba Iglesias-González, Brice Marc René Appenzeller, John Paul Okimat, Jean-Baptiste Fini, Barbara Demeneix, Sophie Vaslin-Reimann, Sophie Lardy-Fontan, Nelson Guma, Petra Spirhanzlova
      Environmental Science and Pollution Research.2020; 27(22): 27914.     CrossRef
    • Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
      Manelle Ramadan, Blake Cooper, Nikki Gillum Posnack
      Birth Defects Research.2020; 112(17): 1362.     CrossRef
    • Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays
      Asuka A. Orr, Shujun He, Meichen Wang, Alicia Goodall, Sara E. Hearon, Timothy D. Phillips, Phanourios Tamamis
      Computers & Chemical Engineering.2020; 143: 107063.     CrossRef
    • Challenges of plastic waste generation and management in sub-Saharan Africa: A review
      Olusola Olaitan Ayeleru, Sisanda Dlova, Ojo Jeremiah Akinribide, Freeman Ntuli, Williams Kehinde Kupolati, Paula Facal Marina, Anton Blencowe, Peter Apata Olubambi
      Waste Management.2020; 110: 24.     CrossRef
    • Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage
      Rubén Martínez, Laia Navarro-Martín, Morgane van Antro, Inmaculada Fuertes, Marta Casado, Carlos Barata, Benjamin Piña
      Chemosphere.2020; 246: 125704.     CrossRef
    • Plastics derived endocrine‐disrupting compounds and their effects on early development
      Sanjay Basak, Mrinal K. Das, Asim K. Duttaroy
      Birth Defects Research.2020; 112(17): 1308.     CrossRef
    • Estimated Dietary Bisphenol-A Exposure and Adiposity in Samoan Mothers and Children
      Lacey W. Heinsberg, Christina N.N. Bui, Jennifer C. Hartle, Susan M. Sereika, Courtney C. Choy, Dongqing Wang, Christina Soti-Ulberg, Take Naseri, Muagututia Sefuiva Reupena, Rachel L. Duckham, Jennifer J. Park, Nicola L. Hawley, Nicole C. Deziel
      Toxics.2020; 8(3): 67.     CrossRef
    • Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
      Ilaria Cimmino, Francesca Fiory, Giuseppe Perruolo, Claudia Miele, Francesco Beguinot, Pietro Formisano, Francesco Oriente
      International Journal of Molecular Sciences.2020; 21(16): 5761.     CrossRef
    • Toxicological considerations of nano-sized plastics
      PA Stapleton
      AIMS Environmental Science.2019; 6(5): 367.     CrossRef

    • PubReader PubReader
    • Cite this Article
      Cite this Article
      export Copy Download
      Close
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

      Format:
      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      Include:
      • Citation for the content below
      Concern about the Safety of Bisphenol A Substitutes
      Diabetes Metab J. 2019;43(1):46-48.   Published online February 19, 2019
      Close
    • XML DownloadXML Download
    Figure
    Moon MK. Concern about the Safety of Bisphenol A Substitutes. Diabetes Metab J. 2019;43(1):46-48.
    DOI: https://doi.org/10.4093/dmj.2019.0027.

    Diabetes Metab J : Diabetes & Metabolism Journal
    Close layer