Concern about the Safety of Bisphenol A Substitutes

Min Kyong Moon

doi:10.4093/dmj.2019.0027

Articles

Page Path: HOME > Diabetes Metab J > Volume 43(1); 2019 > Article

Editorial Epidemiology Concern about the Safety of Bisphenol A Substitutes: Min Kyong Moon^1,2; Diabetes & Metabolism Journal 2019;43(1):46-48.
DOI: https://doi.org/10.4093/dmj.2019.0027
Published online: February 19, 2019

6,573 Views
85 Download
68 Web of Science
67 Crossref
69 Scopus

¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

²Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.

Corresponding author: Min Kyong Moon. Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. mkmoon@snu.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

prev next

Full Article

Download PDF

NOTES
REFERENCES
About this article

Bisphenol A (BPA) is a base material for the production of polycarbonate plastic and epoxy resin, and it is one of the most produced chemicals [1]. BPA is a well-known endocrine disruptor and has a weak estrogenic effect. The adverse effects of BPA are largely related to its estrogenic activity [2 3], and they can disturb reproductive function. In addition, recent epidemiologic evidence has also shown that BPA is implicated in cardiovascular disease, type 2 diabetes mellitus, and obesity: high serum or urine BPA levels have been positively associated with diabetes mellitus [4 5], cardiovascular disease [4], obesity, and insulin resistance [6]. Therefore, BPA has been regulated in many countries. BPA was banned in baby bottles in Canada in 2008, in France in 2010, and in the European Union in 2011 [7]. Such regulations have led to the development of substitutes such as bisphenol S (BPS) and bisphenol F (BPF).

These BPA substitutes-based products are consumed under the label of “BPA-free.” This term gives the impression that the products are safe, but the safety of the substitutes is not fully verified [8 9]. Because of structural similarities with BPA (Fig. 1), these alternatives also show endocrine disruption effects like BPA, and many studies on adverse health effects of these alternatives are being reported.

In this issue of the Diabetes and Metabolism Journal, Liu et al. [10] evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents using data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014. They found that exposure to BPF was positively associated with higher risk of obesity in children and adolescents, especially in boys. In terms of BPS, they did not observe significant associations with either general obesity or abdominal obesity. In their previous article, BPF or BPS was not significantly associated with obesity in U.S. adults [11]. BPS and BPF may have less harmful impact on health than BPA. However, as noted by the authors, since BPS or BPF has not replaced BPA for a long time, no significant results could be obtained due to their relative low exposure.

In a systematic review regarding comparison of the hormonal activity of BPA substitutes, the hormonal activities of BPS and BPF were in the same order of magnitude and of similar action as BPA (estrogenic, anti-estrogenic, androgenic, and anti-androgenic) in vitro and in vivo [9]. BPS and BPF showed altered organ weights, reproductive end points, and enzyme expression. In a recent study, the agonistic and/or antagonistic activities of BPA and its eight analogues (BPAF, BPAP, BPB, BPE, BPF, BPP, BPS, and BPZ) against human nuclear receptors (estrogen receptors [ERs], androgen receptor, glucocorticoid receptor, pregnane X receptor, and constitutive androstane receptor) were characterized via in vitro transactivation assays (Fig. 2) [12]. All the test compounds, except for BPP, showed both ERα- and ERβ-agonistic activities, with BPAF being the most potent. BPF and BPS were found to show weaker estrogenic activities than BPA. Their results suggested that BPA analogues demonstrate multiple effects via human nuclear receptors in a similar manner to BPA, and several analogues might have more potent endocrine-disrupting activity than BPA.

In Korea, BPS are used for thermal receipt papers and BPF as a water pipe coating agent instead of BPA [13]. In the study measuring the concentrations of BPA, BPS, and BPF in the rivers of Japan, Korea, China, and India, BPF was the major bisphenol in rivers and the levels exceeded those of BPA. In the Han River in Korea, median concentrations of BPA, BPS, and BPF were 144, 41, and 555 ng/L, respectively. These were much higher compared with Nakdong River or Yeongsan River, where no BPF was detected [14]. This could be associated with the use of BPF-coated water pipes in Seoul [13]. In 2012, Liao et al. [14] analyzed BPS concentrations in 315 urine samples collected from the general populations in the United States and seven Asian countries including Korea. The urinary BPS concentration in Korea was very low (0.030 ng/mL) compared with Japan (1.18 ng/mL), United States (0.299 ng/mL) or China (0.226 ng/mL). However, the results are likely to change as BPS is replacing BPA for thermal receipt papers.

Because BPA substitutes such as BPS and BPF have similar structures to BPA, they appear to have similar metabolism, potencies, and action to BPA. In addition, they may pose similar potential health hazards as BPA. Continued biomonitoring of these bisphenols in populations and thorough investigations on their health effects in humans are needed. Manufacturers should continue to seek alternative safe materials rather than merely replacing BPA with bisphenol analogs.

NOTES

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

REFERENCES

1. Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, Soto AM. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 2007;148:116-127. Article PubMed
2. Hiroi H, Tsutsumi O, Momoeda M, Takai Y, Osuga Y, Taketani Y. Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. Endocr J 1999;46:773-778. Article PubMed
3. Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y. The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type. Endocr J 2002;49:465-471. Article PubMed
4. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008;300:1303-1310. Article PubMed
5. Shankar A, Teppala S. Relationship between urinary bisphenol A levels and diabetes mellitus. J Clin Endocrinol Metab 2011;96:3822-3826. Article PubMed PMC
6. Wang T, Li M, Chen B, Xu M, Xu Y, Huang Y, Lu J, Chen Y, Wang W, Li X, Liu Y, Bi Y, Lai S, Ning G. Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 2012;97:E223-E227. Article PubMed PDF
7. Cano-Nicolau J, Vaillant C, Pellegrini E, Charlier TD, Kah O, Coumailleau P. Estrogenic effects of several BPA analogs in the developing zebrafish brain. Front Neurosci 2016;10:112Article PubMed PMC
8. Eladak S, Grisin T, Moison D, Guerquin MJ, N'Tumba-Byn T, Pozzi-Gaudin S, Benachi A, Livera G, Rouiller-Fabre V, Habert R. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril 2015;103:11-21. Article PubMed
9. Rochester JR, Bolden AL. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Perspect 2015;123:643-650. Article PubMed PMC
10. Liu B, Lehmler HJ, Sun Y, Xu G, Sun Q, Snetselaar LG, Wallace RB, Bao W. Association of bisphenol A and its substitutes, bisphenol F and bisphenol S, with obesity in United States children and adolescents. Diabetes Metab J 2019;43:59-75. Article PubMed PMC PDF
11. Liu B, Lehmler HJ, Sun Y, Xu G, Liu Y, Zong G, Sun Q, Hu FB, Wallace RB, Bao W. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 2017;1:e114-e122. Article PubMed PMC
12. Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K. Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology 2019;413:48-55. Article PubMed
13. Song CY, Kim W, Gye MC. Current state of use and the risks of bisphenols: a minireview. Korean J Environ Biol 2017;35:581-594.Article
14. Liao C, Liu F, Alomirah H, Loi VD, Mohd MA, Moon HB, Nakata H, Kannan K. Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures. Environ Sci Technol 2012;46:6860-6866. Article PubMed

Fig. 1

Chemical structures of (A) bisphenol A, (B) bisphenol S, and (C) bisphenol F.

Fig. 2

Profiling of bisphenol A (BPA) and eight its analogues on transcriptional activity via human nuclear receptors. Adapted from Kojima et al. [12], with permission from Elsevier. ERα, human estrogen receptors α; ERβ, human estrogen receptors β; AR, androgen receptor; GR, glucocorticoid receptor; PXR, pregnane X receptor; CAR, constitutive androstane receptor; REC20, the concentrations of the compound equal to 20% of the maximal response of the positive control intensity; RIC20, the concentrations of the test compounds showing 20% inhibition of the activities induced by the endogenous hormones or vehicle control.

Figure & Data

References

Citations

Citations to this article as recorded by

The use of alternatives assessment in chemicals management policies: Needs for greater impact
Catherine Rudisill, Molly Jacobs, Monika Roy, Lauren Brown, Rae Eaton, Tim Malloy, Holly Davies, Joel Tickner
Integrated Environmental Assessment and Management.2024; 20(4): 1035. CrossRef
Toxic Ingredients in Personal Care Products: A Dermatological Perspective
Rachel R. Lin, Deborah A. Lin, Andrea D. Maderal
Dermatitis®.2024; 35(2): 121. CrossRef
Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
Sonal Sangwan, Rajasri Bhattacharyya, Dibyajyoti Banerjee
Liver International.2024; 44(5): 1093. CrossRef
Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor
Rajesh Kumar Pathak, Da-Woon Jung, Seung-Hee Shin, Buom-Yong Ryu, Hee-Seok Lee, Jun-Mo Kim
Journal of Hazardous Materials.2024; 469: 133935. CrossRef
Epoxidized technical Kraft lignin as a particulate resin component for high-performance anticorrosive coatings
Alessio Truncali, Tejasvi Laxminarayan, Narayanan Rajagopalan, Claus Erik Weinell, Søren Kiil, Mats Johansson
Journal of Coatings Technology and Research.2024;[Epub] CrossRef
Bisphenol A analysis and quantification inconsistencies via HPLC-UV: a systematic review with technical notes
Cristian-Emilian Pop, Bogdan Andrei Miu, Dávid Németh, Robert Wolff, Dan Florin Mihăilescu, Sorin Marius Avramescu, Maria Mernea
Discover Applied Sciences.2024;[Epub] CrossRef
Gene Target Prediction of Environmental Chemicals Using Coupled Matrix–Matrix Completion
Kai Wang, Nicole Kim, Maryam Bagherian, Kai Li, Elysia Chou, Justin A. Colacino, Dana C. Dolinoy, Maureen A. Sartor
Environmental Science & Technology.2024; 58(13): 5889. CrossRef
Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system
Melissa Dibbernn Ganzerla, Nathalia de Carvalho Indolfo, Larissa Cleres Moreira Oliveira, Tabata Renee Doratioto, Thayná Mendonça Avelino, Rafael Junior de Azevedo, Larissa Bueno Tofani, Maiara Ferreira Terra, Giovanna Blazutti Elias, Irene Layane de Sous
Toxicology in Vitro.2024; 98: 105849. CrossRef
Experimental toxicological assessment of the degree of hazard of a mixture of chemical compounds migrating from materials intended for use in drinking water supply
Anna V. Alekseeva, Yuriy A. Rakhmanin, Rufina I. Mikhailova, Natalia A. Egorova, Ludmila V. Khripach, Valentina V. Yurchenko
Hygiene and sanitation.2024; 103(4): 365. CrossRef
Impacts associated with the plastic polymers polycarbonate, polystyrene, polyvinyl chloride, and polybutadiene across their life cycle: A review
Bhedita J. Seewoo, Enoch V.S. Wong, Yannick R. Mulders, Louise M. Goodes, Ela Eroglu, Manuel Brunner, Aleksandra Gozt, Priyanka Toshniwal, Christos Symeonides, Sarah A. Dunlop
Heliyon.2024; 10(12): e32912. CrossRef
Thyroid-disrupting effects of bisphenol S in male Wistar albino rats: Histopathological lesions, follicle cell proliferation and apoptosis, and biochemical changes
Müşerref Bostancı, Burak Kaptaner, Abdulahad Doğan
Toxicology and Industrial Health.2024; 40(11): 559. CrossRef
Bisphenol S Exposure Perturbs Epididymis Function of Adult Male Golden Hamster, Mesocricetus auratus
Jitendra Kumar, Chandana Haldar
Journal of Endocrinology and Reproduction.2024; : 35. CrossRef
The risk of prenatal bisphenol A exposure in early life neurodevelopment: Insights from epigenetic regulation
Norazirah Mat Nayan, Andrean Husin, Rosfaiizah Siran
Early Human Development.2024; 198: 106120. CrossRef
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review
Alexandra E Peters, Emmalee A Ford, Shaun D Roman, Elizabeth G Bromfield, Brett Nixon, Kirsty G Pringle, Jessie M Sutherland
Human Reproduction Update.2024;[Epub] CrossRef
Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
Exposure and Health.2023; 15(1): 53. CrossRef
An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products
John N. Hahladakis, Eleni Iacovidou, Spyridoula Gerassimidou
Integrated Environmental Assessment and Management.2023; 19(1): 45. CrossRef
Bisphenol A alternatives continuously contribute to the endocrine disruption in cetaceans
Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Jiaxue Wu, Yuping Wu
Environment International.2023; 171: 107679. CrossRef
Interactions of Bisphenol A with Artemia franciscana and the ameliorative effect of probiotics
Despoina Giamaki, Malamati Tsiotsiou, Sevnta Chousein Oglou, Maria Touraki
Environmental Toxicology and Pharmacology.2023; 98: 104064. CrossRef
Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years
Sarah Dee Geiger, Salma Musaad, Jennifer Hill, Andréa Aguiar, Susan Schantz
Neurotoxicology and Teratology.2023; 96: 107152. CrossRef
The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S
Soňa Kucharíková, Patrícia Hockicková, Kamila Melnikov, Zuzana Bárdyová, Alžbeta Kaiglová
Toxicology Reports.2023; 10: 341. CrossRef
Endocrine-active and endocrine-disrupting compounds in food – occurrence, formation and relevance
Constanze Stiefel, Florian Stintzing
NFS Journal.2023; 31: 57. CrossRef
Early Environment and Telomeres: a Long-Term Toxic Relationship
José Francisco Herrera-Moreno, Diddier Prada, Andrea A. Baccarelli
Current Environmental Health Reports.2023; 10(2): 112. CrossRef
Bisphenol A prevents MCF‐7 breast cell apoptosis via the inhibition of progesterone receptor transactivation
Masahiro Ogawa, Junya Kitamoto, Takeo Takeda, Megumi Terada
Journal of Biochemical and Molecular Toxicology.2023;[Epub] CrossRef
Interaction of micro(nano)plastics and bisphenols in the environment: A recent perspective on adsorption mechanisms, influencing factors and ecotoxic impacts
Dandan Gao, Muhammad Junaid, Xikun Chen, Hongping Liao, Guanglong Chen, Jun Wang
TrAC Trends in Analytical Chemistry.2023; 165: 117132. CrossRef
Plastic ingestion by two cetacean groups: Ziphiidae and Delphinidae
Sergio López-Martínez, Esther Giménez-Luque, Jose Luis Molina-Pardo, Sandra Manzano-Medina, Héctor Arribas-Arias, Rafael Gavara, Carmen Morales-Caselles, Marga L. Rivas
Environmental Pollution.2023; 333: 121932. CrossRef
Endocrine‐disrupting compounds and metabolomic reprogramming in breast cancer
Cassandra Winz, Wei‐Xing Zong, Nanjoo Suh
Journal of Biochemical and Molecular Toxicology.2023;[Epub] CrossRef
Microwave‐assisted fractionation and functionalization of technical lignin toward thermoset resins
Alessio Truncali, Iuliana Ribca, Jenevieve Yao, Minna Hakkarainen, Mats Johansson
Journal of Applied Polymer Science.2023;[Epub] CrossRef
Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling
Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Frontiers in Endocrinology.2023;[Epub] CrossRef
Gestational exposure to bisphenol S induces microvesicular steatosis in male rat offspring by modulating metaflammation
Archana Molangiri, Saikanth Varma, Kota Sri Naga Hridayanka, Myadara Srinivas, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
Science of The Total Environment.2023; 904: 166775. CrossRef
The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals
Bhedita J Seewoo, Louise M Goodes, Louise Mofflin, Yannick R Mulders, Enoch VS Wong, Priyanka Toshniwal, Manuel Brunner, Jennifer Alex, Brady Johnston, Ahmed Elagali, Aleksandra Gozt, Greg Lyle, Omrik Choudhury, Terena Solomons, Christos Symeonides, Sarah
Environment International.2023; 181: 108225. CrossRef
In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th Differentiation
Pia Štrukelj Pahović, Martina Iulini, Ambra Maddalon, Valentina Galbiati, Erica Buoso, Marija Sollner Dolenc, Emanuela Corsini
Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(14): 1750. CrossRef
Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation
Handule Lee, Juyoung Park, Kwangsik Park
Toxics.2023; 11(12): 986. CrossRef
Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products
Manel Chebbi, Asma Beltifa, Sana Alibi, Giuseppa Di Bella, Vincenzo Loturco, Olivier Sire, Hedi Ben Mansour, Véronique Le Tilly
International Journal of Environmental Health Research.2022; 32(2): 252. CrossRef
Determination of contamination levels for multiple endocrine disruptors in hair from a non-occupationally exposed population living in Liege (Belgium)
Julien Claessens, Catherine Pirard, Corinne Charlier
Science of The Total Environment.2022; 815: 152734. CrossRef
Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa
Mimi Nguyen, Reem Sabry, Ola S. Davis, Laura A. Favetta
Genes.2022; 13(1): 142. CrossRef
Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study
Ruth Naomi, Muhammad Dain Yazid, Hasnah Bahari, Yong Yoke Keong, Retnagowri Rajandram, Hashim Embong, Soo Huat Teoh, Shariff Halim, Fezah Othman
International Journal of Molecular Sciences.2022; 23(6): 2969. CrossRef
The Importance of Addressing Early-Life Environmental Exposures in Cancer Epidemiology
Nicole M. Niehoff, Mandy Goldberg, Alexandra J. White
Current Epidemiology Reports.2022; 9(2): 49. CrossRef
Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis
Hong-Mei Li, Yuan-Yuan Li, Ying-Chi Zhang, Jin-Bo Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin
Ecotoxicology and Environmental Safety.2022; 236: 113453. CrossRef
Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F
Somin Lee, Kyu Sup An, Hye Jin Kim, Hye Jin Noh, JaeWon Lee, Jiho Lee, Kyung Seuk Song, Chanhee Chae, Hyeon Yeol Ryu
Archives of Toxicology.2022; 96(6): 1711. CrossRef
Detection of Bisphenol A and Four Analogues in Atmospheric Emissions in Petrochemical Complexes Producing Polypropylene in South America
Joaquín Hernández Fernández, Yoleima Guerra, Heidi Cano
Molecules.2022; 27(15): 4832. CrossRef
Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis
Chen Huang, Yuqin Wang, Xiao Lin, Ting Fung Chan, Keng Po Lai, Rong Li
Ecotoxicology and Environmental Safety.2022; 242: 113897. CrossRef
Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study
Mahendra K. Pant, Abul. H. Ahmad, Manisha Naithani, Jayanti Pant
Clinical and Experimental Pediatrics.2022; 65(9): 459. CrossRef
Synthesis and reproductive toxicity of bisphenol A analogs with cyclic side chains in Caenorhabditis elegans
Andrew H Roberts, John E Bowen, Xinrui Zhou, Isabella Burke, Maxwell H Wenaas, Timothy A Blake, Shannon C Timmons, Aleksandra Kuzmanov
Toxicology and Industrial Health.2022; 38(10): 665. CrossRef
Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives
Poonam Sharma, Reena Vishwakarma, Sunita Varjani, Krishna Gautam, Vivek K. Gaur, Alvina Farooqui, Raveendran Sindhu, Parameswaran Binod, Mukesh Kumar Awasthi, Preeti Chaturvedi, Ashok Pandey
Environmental Research.2022; 215: 114198. CrossRef
Climate change and the water quality threats posed by the emerging contaminants per- and polyfluoroalkyl substances (PFAS) and microplastics
Malcolm J. Gander
Water International.2022; : 1. CrossRef
Bisphenol AF induces multiple behavioral and biochemical changes in zebrafish (Danio rerio) at different life stages
Chenyang Rao, Xianglin Cao, Lulu Li, Jiameng Zhou, Dandan Sun, Baohua Li, Suqi Guo, Rongjie Yuan, Han Cui, Jianjun Chen
Aquatic Toxicology.2022; 253: 106345. CrossRef
Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
Niyazi Emre Kurşunoğlu, Banu Pinar Sarer Yurekli
World Journal of Clinical Cases.2022; 10(31): 11226. CrossRef
Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway
Emilia Kourmaeva, Reem Sabry, Laura A. Favetta
Frontiers in Endocrinology.2022;[Epub] CrossRef
Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology
Maria Popescu, Talia B. Feldman, Tanuja Chitnis
Frontiers in Pharmacology.2021;[Epub] CrossRef
Determination of Bisphenol Analogues in Infant Formula Products from India and Evaluating the Health Risk in Infants Asssociated with Their Exposure
Kajal Karsauliya, Manisha Bhateria, Ashish Sonker, Sheelendra Pratap Singh
Journal of Agricultural and Food Chemistry.2021; 69(13): 3932. CrossRef
Bisphenols' occurrence in bivalves as sentinel of environmental contamination
Elena Baralla, Valeria Pasciu, Maria Vittoria Varoni, Maria Nieddu, Roberto Demuro, Maria Piera Demontis
Science of The Total Environment.2021; 785: 147263. CrossRef
Bisphenol A and its effects on the systemic organs of children
Sarah Zulkifli, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir, Noor Shafina Mohd Nor
European Journal of Pediatrics.2021; 180(10): 3111. CrossRef
Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis
Yue Niu, Min Zhu, Mengqi Dong, Jinbo Li, Yuanyuan Li, Yiming Xiong, Pengyan Liu, Zhanfen Qin
Aquatic Toxicology.2021; 237: 105902. CrossRef
Urinary Bisphenol A Concentrations and Parameters of Ovarian Reserve among Women from a Fertility Clinic
Ewelina Czubacka, Bartosz Wielgomas, Anna Klimowska, Michał Radwan, Paweł Radwan, Anetta Karwacka, Paweł Kałużny, Joanna Jurewicz
International Journal of Environmental Research and Public Health.2021; 18(15): 8041. CrossRef
Bisphenol S and Bisphenol F Are Less Disruptive to Cardiac Electrophysiology, as Compared With Bisphenol A
Tomas M Prudencio, Luther M Swift, Devon Guerrelli, Blake Cooper, Marissa Reilly, Nina Ciccarelli, Jiansong Sheng, Rafael Jaimes, Nikki Gillum Posnack
Toxicological Sciences.2021; 183(1): 214. CrossRef
Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation
Hye-Min Kim, Seon-Min Lee, Jungil Choi, Nak-Kyun Soung, Jeong-Doo Heo
Molecules.2021; 26(20): 6100. CrossRef
Plastic pollution: why is it a public health problem?
Andrew Daltry, Lea Merone, Peter Tait
Australian and New Zealand Journal of Public Health.2021; 45(6): 535. CrossRef
Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization
Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin
Environmental Pollution.2020; 260: 113980. CrossRef
Road impact in a protected area with rich biodiversity: the case of the Sebitoli road in Kibale National Park, Uganda
Sabrina Krief, Alba Iglesias-González, Brice Marc René Appenzeller, John Paul Okimat, Jean-Baptiste Fini, Barbara Demeneix, Sophie Vaslin-Reimann, Sophie Lardy-Fontan, Nelson Guma, Petra Spirhanzlova
Environmental Science and Pollution Research.2020; 27(22): 27914. CrossRef
Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
Manelle Ramadan, Blake Cooper, Nikki Gillum Posnack
Birth Defects Research.2020; 112(17): 1362. CrossRef
Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays
Asuka A. Orr, Shujun He, Meichen Wang, Alicia Goodall, Sara E. Hearon, Timothy D. Phillips, Phanourios Tamamis
Computers & Chemical Engineering.2020; 143: 107063. CrossRef
Challenges of plastic waste generation and management in sub-Saharan Africa: A review
Olusola Olaitan Ayeleru, Sisanda Dlova, Ojo Jeremiah Akinribide, Freeman Ntuli, Williams Kehinde Kupolati, Paula Facal Marina, Anton Blencowe, Peter Apata Olubambi
Waste Management.2020; 110: 24. CrossRef
Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage
Rubén Martínez, Laia Navarro-Martín, Morgane van Antro, Inmaculada Fuertes, Marta Casado, Carlos Barata, Benjamin Piña
Chemosphere.2020; 246: 125704. CrossRef
Plastics derived endocrine‐disrupting compounds and their effects on early development
Sanjay Basak, Mrinal K. Das, Asim K. Duttaroy
Birth Defects Research.2020; 112(17): 1308. CrossRef
Estimated Dietary Bisphenol-A Exposure and Adiposity in Samoan Mothers and Children
Lacey W. Heinsberg, Christina N.N. Bui, Jennifer C. Hartle, Susan M. Sereika, Courtney C. Choy, Dongqing Wang, Christina Soti-Ulberg, Take Naseri, Muagututia Sefuiva Reupena, Rachel L. Duckham, Jennifer J. Park, Nicola L. Hawley, Nicole C. Deziel
Toxics.2020; 8(3): 67. CrossRef
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Ilaria Cimmino, Francesca Fiory, Giuseppe Perruolo, Claudia Miele, Francesco Beguinot, Pietro Formisano, Francesco Oriente
International Journal of Molecular Sciences.2020; 21(16): 5761. CrossRef
Toxicological considerations of nano-sized plastics
PA Stapleton
AIMS Environmental Science.2019; 6(5): 367. CrossRef

PubReader

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Concern about the Safety of Bisphenol A Substitutes

Diabetes Metab J. 2019;43(1):46-48. Published online February 19, 2019

DOI: https://doi.org/10.4093/dmj.2019.0027

XML Download

Figure

Concern about the Safety of Bisphenol A Substitutes

Fig. 1 Chemical structures of (A) bisphenol A, (B) bisphenol S, and (C) bisphenol F.

Fig. 2 Profiling of bisphenol A (BPA) and eight its analogues on transcriptional activity via human nuclear receptors. Adapted from Kojima et al. [12], with permission from Elsevier. ERα, human estrogen receptors α; ERβ, human estrogen receptors β; AR, androgen receptor; GR, glucocorticoid receptor; PXR, pregnane X receptor; CAR, constitutive androstane receptor; REC20, the concentrations of the compound equal to 20% of the maximal response of the positive control intensity; RIC20, the concentrations of the test compounds showing 20% inhibition of the activities induced by the endogenous hormones or vehicle control.

Fig. 1

Fig. 2

Concern about the Safety of Bisphenol A Substitutes

About this article

Moon MK. Concern about the Safety of Bisphenol A Substitutes. Diabetes Metab J. 2019;43(1):46-48.

DOI: https://doi.org/10.4093/dmj.2019.0027.

Download citation ↓