Response: The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women (Diabetes Metab J 2017;41:205-12)

Sasan Amanat; Mohammad Fararouei; Mostafa Dianatinasab

doi:10.4093/dmj.2017.41.4.324

Articles

Page Path: HOME > Diabetes Metab J > Volume 41(4); 2017 > Article

Response Response: The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women (Diabetes Metab J 2017;41:205-12): Sasan Amanat¹, Mohammad Fararouei², Mostafa Dianatinasab²; Diabetes & Metabolism Journal 2017;41(4):324-325.
DOI: https://doi.org/10.4093/dmj.2017.41.4.324
Published online: August 22, 2017

3,109 Views
32 Download

¹Department of nutrition sciences, Evaz School of Health, Larestan University of Medical Sciencens, Larestan, Iran.

²Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Corresponding author: Mostafa Dianatinasab. Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. dianati.epid@gmail.com

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Full Article

Download PDF

NOTES
REFERENCES

We appreciate Dr. Kim's interest and comments on our article entitled “The effect of 12 weeks aerobic, resistance, and combined exercises on omentin-1 levels and insulin resistance among type 2 diabetic middle-aged women” which was published in Diabetes and Metabolism Journal [1].

Omentin is an adipokine, which is expressed and secreted from adipose tissue [2]. Among total body fat storages, visceral adipose tissue (VAT) is distinct in omentin secretion. Serum omentin concentration is related to obesity and type 2 diabetes mellitus [3]. In addition, recent studies reported that omentin level in the bloodstream is increased by lifestyle modification or exercise [4 5]. To understand what is the exact mechanisms of rise in omentin-1 secretion when the above interventions are applied and whether fat depots is only a causal link between lifestyle and change in omentin production or both healthy lifestyle (including physical exercise) and change in fat depots are the main causes for this achievement, measurement of body fat storage is indispensable. In this regard, we completely agree with Dr. Kim that measurement of abdominal circumference could have improved our understanding of the effect of exercise on central obesity and omentin secretion. However, because of cultural and religious sensitivities, we preferred not to measure abdominal circumference of female participants as otherwise, we would have significant decrease in participation rate. Anyhow, due to the following reasons we believe our decision did not critically limit the findings of our study.

VAT can be divided into omental, mesenteric, retroperitoneal, gonadal, and pericardial [6]. As Yang et al. [7] suggested, omental fat expresses and secrets much greater omentin compare to other VAT components and subcutaneous adipose tissue (SAT). Abdominal circumference is a good meter for change in SAT and mesenteric but not omental fat and in return omentin production [8]. Indeed, more accurate methods for measuring different parts of VAT are high-resolution magnetic resonance imaging and computerized tomography scan. Not of these methods were decided to be used in our study due to high costs and potential side effects [9 10].

As suggested by Dr. Kim, We also believe more studies are needed to clarify the mechanisms that physical exercise affect omentin secretion from visceral fat depots.

NOTES

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

REFERENCES

1. AminiLari Z, Fararouei M, Amanat S, Sinaei E, Dianatinasab S, AminiLari M, Daneshi N, Dianatinasab M. The effect of 12 weeks aerobic, resistance, and combined exercises on omentin-1 levels and insulin resistance among type 2 diabetic middle-aged women. Diabetes Metab J 2017;41:205-212. Article PubMed PMC PDF
2. Tan BK, Adya R, Randeva HS. Omentin: a novel link between inflammation, diabesity, and cardiovascular disease. Trends Cardiovasc Med 2010;20:143-148. Article PubMed
3. Pan HY, Guo L, Li Q. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res Clin Pract 2010;88:29-33. Article PubMed
4. Wilms B, Ernst B, Gerig R, Schultes B. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training. Exp Clin Endocrinol Diabetes 2015;123:187-192. Article PubMed
5. Urbanova M, Dostalova I, Trachta P, Drapalova J, Kavalkova P, Haluzikova D, Matoulek M, Lacinova Z, Mraz M, Kasalicky M, Haluzik M. Serum concentrations and subcutaneous adipose tissue mRNA expression of omentin in morbid obesity and type 2 diabetes mellitus: the effect of very-low-calorie diet, physical activity and laparoscopic sleeve gastrectomy. Physiol Res 2014;63:207-218. PubMed
6. Bjorndal B, Burri L, Staalesen V, Skorve J, Berge RK. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes 2011;2011:490650PubMed PMC
7. Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006;290:E1253-E1261. Article PubMed
8. Kuk JL, Lee S, Heymsfield SB, Ross R. Waist circumference and abdominal adipose tissue distribution: influence of age and sex. Am J Clin Nutr 2005;81:1330-1334. Article PubMed
9. Smith-Bindman R, Lipson J, Marcus R, Kim KP, Mahesh M, Gould R, Berrington de Gonzalez A, Miglioretti DL. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med 2009;169:2078-2086. Article PubMed PMC
10. Shen W, Wang Z, Punyanita M, Lei J, Sinav A, Kral JG, Imielinska C, Ross R, Heymsfield SB. Adipose tissue quantification by imaging methods: a proposed classification. Obes Res 2003;11:5-16. Article PubMed PMC

Figure & Data

References

Citations

Citations to this article as recorded by

PubReader

Cite

CITE: export Copy Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Response: The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women (Diabetes Metab J 2017;41:205-12)

Diabetes Metab J. 2017;41(4):324-325. Published online August 22, 2017

DOI: https://doi.org/10.4093/dmj.2017.41.4.324

XML Download