INTRODUCTION

The adult gut microbiota comprises 10 to 100 trillion microorganisms, which is equivalent to ten times the number of our total somatic and germ cells [1]. Further, the collective genomes of gut microbiota (microbiome) contain 100- to 150-fold more genes than our own genome [2]. The gut microbiota has coevolved with humans and has shown profound effects on various host responses. Recent findings have suggested that an altered gut microbial composition is associated with metabolic diseases, including obesity, diabetes, or non-alcoholic fatty liver disease. These findings have indicated that the gut microbiota should be considered as an important factor to modulate host metabolism and metabolic disorders.

OBESITY-ASSOCIATED CHANGES IN THE COMPOSITION OF INTESTINAL MICROBIOTA

The gut microbiota plays an important role in the regulation of the host's metabolism and the extraction of energy from ingested food. Gut microbiota have not only the beneficial functions for the host but also the pathophysiological interactions with the host, particularly in the case of obesity and related metabolic disorders. Recent studies have shown that changes in the gut microbiota may be related in the pathogenesis of obesity and diabetes. For example, germ-free mice are protected from high fat diet (HFD)-induced obesity and metabolic dysfunction, including glucose intolerance, which is due to derepression of fasting-induced adipose factor (Fiaf), an inhibitor of lipoprotein lipase (LPL) [134]. Additionally, the colonization of germ-free animals with gut microbiota isolated from conventionally raised obese donors led to a significant increase in body fat content and insulin resistance in recipient mice [56]. Most bacterial species in the mouse and human gut belong to the phyla Bacteroidetes and Firmicutes. Compared with their lean counterparts, leptin-deficient ob/ob mice showed a decrease in Bacteroidetes and a corresponding increase in Firmicutes [7]. Interestingly, studies with humans also have shown that gut microbiota composition differs between obese and lean subjects [57]. Recently, two large metagenome-wide association studies reported that subjects with type 2 diabetes mellitus (T2DM) had a lower proportion of butyrate-producing Clostridiales (Roseburia and Faecalibacterium prausnitzii) and greater proportions of Clostridiales that do not produce butyrate, suggesting a protective role of butyrate-producing bacteria against T2DM [89].

Currently, it is not known whether these changes in the intestinal microbiota composition are secondary to the altered gastrointestinal motility and small intestinal bacterial overgrowth that are often seen in T2DM. Nevertheless, selected intestinal bacterial strains may function in the clinic as early diagnostic markers to better identify obese subjects who might be prone to develop T2DM, and provide a novel therapeutic modality against obesity or T2DM.

MECHANISMS BY WHICH INTESTINAL MICROBIOTA ARE ASSOCIATED WITH OBESITY AND DIABETES

Short-chain fatty acids

An essential role of gut microbiota is the fermentation of dietary polysaccharides that the host cannot otherwise digest. Dietary fibers constitute the indigestible portion of plant foods containing insoluble and soluble fibers. These soluble fibers are digested by enzymes derived from the gut microbiota into short-chain fatty acids (SCFAs). SCFAs (butyrate, acetate, and propionate) are absorbed in the intestines and used as energy by the host. In addition to their role as energy substrates, SCFAs function as regulators of food or energy intake [10] and inflammation [11]. It is well known that SCFAs are associated with increased satiety and reduced food intake [10]. SCFAs bind to G protein-coupled receptors, (GPCRs) such as GPR41 and GPR43, which are expressed in the enteroendocrine cells [12]. This action leads to the secretion of certain peptide hormones, such as peptide YY (PYY), that are released basolaterally into the systemic circulation, enabling a form of communication between the gut milieu and the host. Reduced food intake is, in part, due to the increases in the gut hormones, such as glucagon-like peptide (GLP)-1 and PYY [13] which decrease appetite and energy intake, and due to the decreased release of the gut peptide ghrelin, which increases food intake through effects on the hypothalamic and brainstem reward-related circuits (Fig. 1) [14]. SCFAs-mediated activation of GPR43 resulted in suppression of insulin signaling in the adipose tissue subsequently preventing fat accumulation [15]. Recent study reported that dietary soluble fibers exert their antiobesity and antidiabetic effects via the induction of intestinal gluconeogenesis (IGN), which is contrary to the general idea that gluconeogenesis impairs glucose tolerance [16]. Butyrate activates IGN gene expression through a cAMP-dependent mechanism, while propionate, itself a substrate of IGN, activates IGN gene expression via a gut-brain neural circuit [16]. Glucose released by IGN is detected by a portal vein glucose sensor that signals to the brain through the peripheral nervous system, thus exerting beneficial effects on food intake and improving glucose tolerance (Fig. 1)[1617].

Gut permeability and metabolic endotoxemia

Several recent studies have suggested that disruption of the gut barrier function and the gut microbiota-derived endotoxemia could contribute to the pathogenesis of obesity and T2DM [1819]. A HFD dramatically increased gut permeability and reduced the expression of tight junction protein, such as zonula occludens-1 and occludin, in the intestinal epithelial cells of mice (Fig. 2) [20]. Disruption of the gut barrier in genetically or HFD-induced obese mice increased gut permeability, resulting in the leakage of lipopolysaccharide into the portal blood circulation (Fig. 2) [212223]. Consistent with this concept, the modulation of the gut microbiota composition with antibiotics or prebiotics improved gut permeability, reduced metabolic endotoxemia, lowered inflammation, and alleviated glucose intolerance [24].

INTESTINAL MICROBIOTA MODULATION AS NOVEL THERAPEUTIC STRATEGIES FOR OBESITY AND DIABETES

Prebiotics

Prebiotics are non-digestible but fermentable polysaccharides, such as inulin, fructo-, oligosaccharides, galato-oligosaccharides, or lactulose. Foods artificially enriched with these fibers are defined as prebiotics, which promote SCFA production and the growth of beneficial bacteria, especially Bifidobacterium and Lactobacillus [25]. Studies in healthy humans and rodents have demonstrated that prebiotic consumption reduces hunger and enhances satiety [26]. As discussed above, this modulation of ingestive behavior is mediated, in part, by SCFA-induced changes in gut peptide secretion. Additionally, by promoting Bifidobacterium populations, prebiotics improve gut barrier function [27].

Probiotics

Probiotics are defined as live microorganisms that confer a beneficial health effect on the host when administered in proper amounts. Some probiotic strains, especially those of the genera Lactobacillus and Bifidobacterium, have been shown to ameliorate obesity and metabolic disorders. The suggested mechanisms include inhibition of the pathogen adhesion to gut mucosa, stabilization of the microbial community, or improvement of the mucosal integrity and barrier function [2728293031]. The improvements of gut barrier function may reflect the actions of the SCFA products of bacterial fermentation. A recent study reported the direct beneficial actions of Lactobacilli on the epithelial cells and on the enteric nervous system regulating gut contractility [32].

Drugs

A recent study showed that metformin, widely used for treatment of T2DM, is able to slow aging in Caenorhabditis elegans by metabolically altering Escherichia coli with which it is cocultured [33]. This effect was found to be due to the alteration of folate and the methionine metabolism of E. coli by metformin. Metformin decreased the methionine cycle and increased the levels of both S-adenosylmethionine (SAMe) and S-adenosylhomocystein. SAMe acts a co-repressor of methionine synthesis genes and also inhibits the folate cycle, resulting in decelerated aging in the worm [33].

Metformin can also affect the intestinal microbiota of mammals. We have demonstrated that metformin is able to affect the mouse microbiota and increase the abundance of Akkermansia muciniphila, a mucin-degrading G (-) anaerobes, in the gut of experimental mice fed a HFD (Fig. 2) [34]. We also observed that the administration of A. muciniphila had similar beneficial metabolic effects to that of metformin administration: (1) increased the number of mucin-producing goblet cells was similarly found after the administration of metformin or A. muciniphila; (2) diminished regulatory T (Treg) cell numbers and elevated interleukin 1β (IL-1β) or IL-6 mRNA expression in the visceral adipose tissue of mice fed a HFD were similarly reversed after the administration of metformin or A. muciniphila. Mucin has recently been shown to enhance delivery of tolerogenic immunoregulatory signal to the intestinal epithelium by forming galectin-3-dectin-1-FcγRIIB complex besides its classical role as a physical barrier [35] This study therefore underscores that drugs, such as metformin, might exert therapeutic effects, at least in part by modulating the gut micriobiota.

Fecal microbiota transplantation

Recently, articles in the literature regarding fecal microbiota transplantation (FMT) have aroused strong interest. FMT is reported to be a highly successful therapy for recurrent Clostridium difficile infection [36]. These results also suggested a potential therapeutic effect of FMT in metabolic syndrome or T2DM. A recent study showed that FMT via a gastroduodenal tube from lean donors into obese subjects with metabolic syndrome induced a significant improvement of insulin sensitivity in the recipients [37]. FMT resulted in an increase of the microbial diversity and a 2.5-fold increase in the proportion of butyrate producer Roseburia intestinalis after 6 weeks of treatment, whereas, fecal SCFA levels were decreased. Despite this first evidence that such as approach could be attractive, more information is needed with larger, well-designed studies to prove whether such approaches are overall beneficial for patients with metabolic syndrome or T2DM.

CONCLUSIONS

Intestinal microbiota may play an important role in the pathogenesis of T2DM by influencing body weight, proinflammatory activity, and insulin resistance (Fig. 1). Future studies are required to increase our understanding of the complex interplay between intestinal microbiota and the host with T2DM and to enable the development of innovative and effective treatments for T2DM.

Acknowledgements

ACKNOWLEDGMENTS

This study was supported by a Global Research Laboratory Grant (K21004000003-12A0500-00310) from the National Research Foundation of Korea and the Ulsan National Institute of Science and Technology Research Fund (2014M3A9D8034459).

NOTES

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

REFERENCES

• 1. Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005;307:1915-1920. ArticlePubMed
• 2. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Dore J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J, Bork P, Ehrlich SD, Wang J. MetaHIT Consortium. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010;464:59-65. ArticlePubMedPMCPDF
• 3. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004;101:15718-15723. ArticlePubMedPMC
• 4. Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 2007;104:979-984. ArticlePubMedPMC
• 5. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006;444:1027-1031. ArticlePubMedPDF
• 6. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008;3:213-223. ArticlePubMedPMC
• 7. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005;102:11070-11075. ArticlePubMedPMC
• 8. Karlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B, Nielsen J, Backhed F. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013;498:99-103. ArticlePubMedPDF
• 9. Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, Peng Y, Zhang D, Jie Z, Wu W, Qin Y, Xue W, Li J, Han L, Lu D, Wu P, Dai Y, Sun X, Li Z, Tang A, Zhong S, Li X, Chen W, Xu R, Wang M, Feng Q, Gong M, Yu J, Zhang Y, Zhang M, Hansen T, Sanchez G, Raes J, Falony G, Okuda S, Almeida M, LeChatelier E, Renault P, Pons N, Batto JM, Zhang Z, Chen H, Yang R, Zheng W, Li S, Yang H, Wang J, Ehrlich SD, Nielsen R, Pedersen O, Kristiansen K, Wang J. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012;490:55-60. ArticlePubMedPDF
• 10. Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 2006;55:1484-1490. ArticlePubMedPDF
• 11. Conterno L, Fava F, Viola R, Tuohy KM. Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? Genes Nutr 2011;6:241-260. ArticlePubMedPMCPDF
• 12. Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki SI, Kuwahara A. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 2008;59(Suppl 2):251-262.
• 13. Delzenne N, Blundell J, Brouns F, Cunningham K, De Graaf K, Erkner A, Lluch A, Mars M, Peters HP, Westerterp-Plantenga M. Gastrointestinal targets of appetite regulation in humans. Obes Rev 2010;11:234-250. ArticlePubMed
• 14. Alvarez-Castro P, Pena L, Cordido F. Ghrelin in obesity, physiological and pharmacological considerations. Mini Rev Med Chem 2013;13:541-552. ArticlePubMed
• 15. Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 2013;4:1829ArticlePubMedPMCPDF
• 16. De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Backhed F, Mithieux G. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 2014;156:84-96. ArticlePubMed
• 17. Delaere F, Duchampt A, Mounien L, Seyer P, Duraffourd C, Zitoun C, Thorens B, Mithieux G. The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing. Mol Metab 2012;2:47-53. ArticlePubMedPMC
• 18. de Kort S, Keszthelyi D, Masclee AA. Leaky gut and diabetes mellitus: what is the link? Obes Rev 2011;12:449-458. ArticlePubMed
• 19. Everard A, Lazarevic V, Gaia N, Johansson M, Stahlman M, Backhed F, Delzenne NM, Schrenzel J, Francois P, Cani PD. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 2014;8:2116-2130. ArticlePubMedPMCPDF
• 20. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009;58:1091-1103. ArticlePubMedPMC
• 21. Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Palu G, Martines D. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G518-G525. ArticlePubMed
• 22. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmee E, Cousin B, Sulpice T, Chamontin B, Ferrieres J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007;56:1761-1772. ArticlePubMedPDF
• 23. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008;57:1470-1481. ArticlePubMedPDF
• 24. Everard A, Lazarevic V, Derrien M, Girard M, Muccioli GG, Neyrinck AM, Possemiers S, Van Holle A, Francois P, de Vos WM, Delzenne NM, Schrenzel J, Cani PD. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011;60:2775-2786. ArticlePubMedPMCPDF
• 25. Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Leotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A. Prebiotic effects: metabolic and health benefits. Br J Nutr 2010;104(Suppl 2):S1-S63. Article
• 26. Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, De Backer F, Neyrinck AM, Delzenne NM. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 2009;90:1236-1243. ArticlePubMed
• 27. Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007;50:2374-2383. ArticlePubMedPDF
• 28. Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermudez-Humaran LG, Smirnova N, Berge M, Sulpice T, Lahtinen S, Ouwehand A, Langella P, Rautonen N, Sansonetti PJ, Burcelin R. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med 2011;3:559-572. ArticlePubMedPMCPDF
• 29. Ewaschuk J, Endersby R, Thiel D, Diaz H, Backer J, Ma M, Churchill T, Madsen K. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007;46:841-850. ArticlePubMed
• 30. Guarner F. Studies with inulin-type fructans on intestinal infections, permeability, and inflammation. J Nutr 2007;137(11 Suppl):2568S-2571S. ArticlePubMed
• 31. Moreira AP, Texeira TF, Ferreira AB, Peluzio Mdo C, Alfenas Rde C. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr 2012;108:801-809. ArticlePubMed
• 32. Lakhan SE, Kirchgessner A. Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction. J Transl Med 2011;9:202ArticlePubMedPMCPDF
• 33. Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cocheme HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 2013;153:228-239. ArticlePubMedPMC
• 34. Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, Bae JW. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 2014;63:727-735. ArticlePubMed
• 35. Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 2013;342:447-453. ArticlePubMedPMC
• 36. van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG, Speelman P, Dijkgraaf MG, Keller JJ. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013;368:407-415. ArticlePubMed
• 37. Vrieze A, Van Nood E, Holleman F, Salojarvi J, Kootte RS, Bartelsman JF, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, Van Hylckama Vlieg JE, Bloks VW, Groen AK, Heilig HG, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JB, Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012;143:913-916.e7. ArticlePubMed

Fig. 1

Gut microbiota regulation of host metabolism. Undigested carbohydrates are fermented by gut microbiota into short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate. SCFAs affect the host metabolism in several ways. SCFAs can signal through G protein-coupled receptor 41 (GPR41) on enteroendocrine cells, inducing the secretion of peptide YY (PYY) which inhibits gut motility, increases intestinal transit rate, and reduces the harvest of energy from the diet. Engagement of GPR43 by SCFAs has been shown to trigger the glucogon-like peptide 1 (GLP-1) to increase insulin sensitivity. Gut microbiota efficiently suppresses fasting-induced adipose factor (Fiaf) expression in the ileum, which inhibits lipoprotein lipase (LPL) activity and fat storage in white adipose tissue. SCFAs-mediated activation of GPR43 results in suppression of insulin signaling in the adipose tissue and subsequent prevention of fat accumulation. SCFAs also activate intestinal gluconeogenesis (IGN) via a gut-brain neural circuit, which can improve glucose metabolism and reduce food intake. VLDL, very low density lipoprotein; FFA, free fatty acid.

Fig. 2

Effect of high fat diet (HFD) and metformin on gut microbiota and intestinal environment. A HFD induces gut microbial alteration, which increases gut permeability and reduces the expression of tight junction protein, such as zonula occludens (ZO)-1 and occludin, in the intestinal epithelial cells, results in the passage of lipopolysaccharide (LPS) into the portal blood circulation. The disruption of the gut barrier function and the gut microbiota-derived endotoxemia could contribute to the pathogenesis of obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). Metformin is able to affect the mouse microbiota and restored the decreased abundance of Akkermansia muciniphila, a mucin-degrading G (-) anaerobes, in the gut of mice fed a HFD to that of mice fed normal chow diet. A. muciniphila had similar beneficial metabolic effects to that of metformin administration.

Figure & Data

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  The American Journal of Clinical Nutrition.2024; 119(3): 599.     CrossRef
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  Atieh Mirzababaei, Maryam Mahmoodi, Abbasali Keshtkar, Haleh Ashraf, Faezeh Abaj, Neda Soveid, Mahya Mehri Hajmir, Mina Radmehr, Pardis Khalili, Khadijeh Mirzaei
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
  Yi Pan, Tong Bu, Xia Deng, Jue Jia, Guoyue Yuan
  Endocrine.2024; 84(1): 1.     CrossRef
• The Role of Gut Microbiota in Obesity
  Anna Celina Durma, Adam Daniel Durma, Adam Smialowski, Leszek Czupryniak
  Advancements of Microbiology.2024; 63(1): 33.     CrossRef
• Engineered Probiotics for the Management of Congenital Metabolic Diseases: A Systematic Review
  Meisam Barati, Erfan Mosharkesh, Amir Hossein Tahmassian, Maryam Khodaei, Masoumeh Jabbari, Ali Kalhori, Mohsen Alipour, Afshin Abdi Ghavidel, Sajad Khalili-Moghadam, Anwar Fathollahi, Sayed Hossein Davoodi
  Preventive Nutrition and Food Science.2024; 29(1): 1.     CrossRef
• The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
  Mohamed J. Saadh, Hani Moslem Ahmed, Zaid Khalid Alani, Rafil Adnan Hussein Al Zuhairi, Zainab M. Almarhoon, Hijaz Ahmad, Mohammed Ubaid, Nathera Hussin Alwan
  NeuroMolecular Medicine.2024;[Epub]     CrossRef
• Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity
  Gabriela Leite, Gillian M. Barlow, Mohamad Rashid, Ava Hosseini, Daniel Cohrs, Gonzalo Parodi, Walter Morales, Stacy Weitsman, Ali Rezaie, Mark Pimentel, Ruchi Mathur
  American Journal of Gastroenterology.2024; 119(6): 1141.     CrossRef
• Ingesting yeast extract causes excitation of neurogenic and myogenic colonic motor patterns in the rat
  Hongfei Li, Yanzhao Ji, Hesheng Luo, Jan D. Huizinga, Ji‐Hong Chen
  Journal of Cellular and Molecular Medicine.2024;[Epub]     CrossRef
• Metformin intolerance in type 2 diabetes mellitus – the possibility of using a multi-strain probiotic
  Mirela Hendel, Krzysztof Irlik, Hanna Kwiendacz, Igor Łoniewski, Karolina Skonieczna-Żydecka, Janusz Gumprecht, Katarzyna Nabrdalik
  Current Topics in Diabetes.2024; (1): 1.     CrossRef
• Probiotics an emerging therapeutic approach towards gut-brain-axis oriented chronic health issues induced by microplastics: A comprehensive review
  Ieshita Pan, Suganiya Umapathy
  Heliyon.2024; 10(11): e32004.     CrossRef
• IL-1 Receptor Contributes to the Maintenance of the Intestinal Barrier via IL-22 during Obesity and Metabolic Syndrome in Experimental Model
  Melissa Machado, Vanessa Rodrigues, Sara Barbosa, Jefferson Elias-Oliveira, Ítalo Pereira, Jéssica Pereira, Thaílla Pacheco, Daniela Carlos
  Microorganisms.2024; 12(8): 1717.     CrossRef
• Gut microbiota characteristics of colorectal cancer patients in Hubei, China, and differences with cohorts from other Chinese regions
  Jianguo Shi, Hexiao Shen, Hui Huang, Lifang Zhan, Wei Chen, Zhuohui Zhou, Yongling Lv, Kai Xiong, Zhiwei Jiang, Qiyi Chen, Lei Liu
  Frontiers in Microbiology.2024;[Epub]     CrossRef
• Consumption of dietary turmeric promotes fat browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice
  Chengcheng Yang, Yao Du, Tong Zhao, Lu Zhao, Lu Liu, Luyao Liu, Xingbin Yang
  Food & Function.2024; 15(15): 8153.     CrossRef
• Acute Pre- and Post-administration of Lactiplantibacillus plantarum 2034 and Its Secretory Metabolites Ameliorates Hyperglycaemia, Hyperlipidaemia, and Oxidative Stress in Diabetic Rats
  Anmol Narang, Muzamil Rashid, Shubham Thakur, Subheet Kumar Jain, Amarjeet Kaur, Sukhraj Kaur
  Probiotics and Antimicrobial Proteins.2024;[Epub]     CrossRef
• The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review
  Xinyu Shen, Chunmin Ma, Yang Yang, Xiaofei Liu, Bing Wang, Yan Wang, Guang Zhang, Xin Bian, Na Zhang
  Foods.2024; 13(17): 2719.     CrossRef
• A study of granulysin and pentraxin 3 genetic polymorphisms and their contribution to acne susceptibility
  Sara Kamal Rizk, Azza Gaber Antar Farag, Safaa Mohamed Awadein Shaeir
  Archives of Dermatological Research.2024;[Epub]     CrossRef
• Ferulic Acid Relieves the Oxidative Stress Induced by Oxidized Fish Oil in Oriental River Prawn (Macrobrachium nipponense) with an Emphasis on Lipid Metabolism and Gut Microbiota
  Xin Liu, Cunxin Sun, Qunlan Zhou, Xiaochuan Zheng, Sufei Jiang, Aimin Wang, Yongquan Han, Gangchun Xu, Bo Liu
  Antioxidants.2024; 13(12): 1463.     CrossRef
• Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis
  Thanawit Chantanaskul, Preecha Patumcharoenpol, Sittirak Roytrakul, Amornthep Kingkaw, Wanwipa Vongsangnak
  International Journal of Molecular Sciences.2024; 25(24): 13533.     CrossRef
• Human Gut Microbiota and Drug Metabolism
  Archana Pant, Tushar K. Maiti, Dinesh Mahajan, Bhabatosh Das
  Microbial Ecology.2023; 86(1): 97.     CrossRef
• Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective
  Shoumi Haldar, Yuvashree Muralidaran, Diana Míguez, Sikandar I. Mulla, Prabhakar Mishra
  Science of The Total Environment.2023; 861: 160571.     CrossRef
• Is there a role for microbiome-based approach in common variable immunodeficiency?
  Remo Poto, Gianluca laniro, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Antonio Gasbarrini, Gilda Varricchi
  Clinical and Experimental Medicine.2023; 23(6): 1981.     CrossRef
• Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis
  Youdong Wan, Shuya Wang, Yifan Niu, Boyang Duo, Yinshuang Liu, Zhenzhen Lu, Ruixue Zhu
  Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
• Dietary fiber intake and fecal short-chain fatty acid concentrations are associated with lower plasma lipopolysaccharide-binding protein and inflammation
  Melisa A. Bailey, Sharon V. Thompson, Annemarie R. Mysonhimer, Jessica N. Bennett, James J. Vanhie, Michael De Lisio, Nicholas A. Burd, Naiman A. Khan, Hannah D. Holscher
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2023; 324(5): G369.     CrossRef
• Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?
  Cheng Zha, Zheng Peng, Kunyuan Huang, Kaifa Tang, Qiang Wang, Lihua Zhu, Bangwei Che, Wei Li, Shenghan Xu, Tao Huang, Ying Yu, Wenjun Zhang
  Frontiers in Oncology.2023;[Epub]     CrossRef
• The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception
  Imke Schamarek, Lars Anders, Rima M. Chakaroun, Peter Kovacs, Kerstin Rohde-Zimmermann
  Nutrition Journal.2023;[Epub]     CrossRef
• Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health
  Hemaa Sree Kumar, Alexander S. Wisner, Jeanine M. Refsnider, Christopher J. Martyniuk, Jasenka Zubcevic
  Frontiers in Physiology.2023;[Epub]     CrossRef
• New approach methodologies (NAMs) to study microbiome–host interactions
  Chen Liu, Jing Jin, Ivonne M.C.M. Rietjens
  Current Opinion in Toxicology.2023; 35: 100406.     CrossRef
• The benefits of edible mushroom polysaccharides for health and their influence on gut microbiota: a review
  Qilong Zhao, Yu Jiang, Qian Zhao, Habasi Patrick Manzi, Li Su, Diru Liu, Xiaodan Huang, Danfeng Long, Zhenchuang Tang, Ying Zhang
  Frontiers in Nutrition.2023;[Epub]     CrossRef
• Extension Region Domain of Soybean 7S Globulin Contributes to Serum Triglyceride‐Lowering Effect via Modulation of Bile Acids Homeostasis
  Kaining Han, Guangxin Feng, Tanghao Li, Zhili Wan, Wenjing Zhao, Xiaoquan Yang
  Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
• Gut microbiome and its clinical implications: exploring the key players in human health
  Sindhuja Koneru, Varshini Thiruvadi, Mayur Ramesh
  Current Opinion in Infectious Diseases.2023; 36(5): 353.     CrossRef
• Effects of probiotic administration on overweight or obese children: a meta-analysis and systematic review
  Ya Li, Tonghua Liu, Lingling Qin, Lili Wu
  Journal of Translational Medicine.2023;[Epub]     CrossRef
• Gut microbiome and prediabetes - a review
  Kartik Kumar Rathi, Nimrata Kumari, Muhammad Daniyal Javaid, Umair Saleem, Eric Mortensen, Yanjiao Zhou, Narinder Maheshwari
  Frontiers in Bacteriology.2023;[Epub]     CrossRef
• Analysis of gut bacteriome of in utero arsenic-exposed mice using 16S rRNA-based metagenomic approach
  Shagun Shukla, Ankita Srivastava, Digvijay Verma, Siddhartha Gangopadhyay, Anchal Chauhan, Vikas Srivastava, Savita Budhwar, Dushyant Tyagi, Deepak Chand Sharma
  Frontiers in Microbiology.2023;[Epub]     CrossRef
• Multi-omics analysis of zebrafish response to tick saliva reveals biological processes associated with alpha-Gal syndrome
  Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Marinela Contreras, Sara Artigas-Jerónimo, Almudena González-García, Christian Gortázar, José de la Fuente
  Biomedicine & Pharmacotherapy.2023; 168: 115829.     CrossRef
• Obesity under the moonlight of c-MYC
  Yulia A. Nevzorova, Francisco Javier Cubero
  Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
• Functional alterations and predictive capacity of gut microbiome in type 2 diabetes
  Nihar Ranjan Dash, Mohammad T. Al Bataineh, Rohia Alili, Habiba Al Safar, Noura Alkhayyal, Edi Prifti, Jean-Daniel Zucker, Eugeni Belda, Karine Clément
  Scientific Reports.2023;[Epub]     CrossRef
• Postbiyotikler ve İnsülin Direnci
  Betül SARIDAĞ DEVRAN, Mendane SAKA
  Van Sağlık Bilimleri Dergisi.2023; 16(3): 268.     CrossRef
• Effects of synbiotic supplementation on the components of metabolic syndrome in military personnel: a double-blind randomised controlled trial
  Karim Parastouei, S Saeidipoor, M Sepandi, S Abbaszadeh, M Taghdir
  BMJ Military Health.2022; 168(5): 362.     CrossRef
• Screening strategies for quorum sensing inhibitors in combating bacterial infections
  Lan Lu, Mingxing Li, Guojuan Yi, Li Liao, Qiang Cheng, Jie Zhu, Bin Zhang, Yingying Wang, Yong Chen, Ming Zeng
  Journal of Pharmaceutical Analysis.2022; 12(1): 1.     CrossRef
• Gut Microbiome Composition and Serum Metabolome Profile Among Individuals With Spinal Cord Injury and Normal Glucose Tolerance or Prediabetes/Type 2 Diabetes
  Jia Li, Casey Morrow, Stephen Barnes, Landon Wilson, Erika D. Womack, Amie McLain, Ceren Yarar-Fisher
  Archives of Physical Medicine and Rehabilitation.2022; 103(4): 702.     CrossRef
• Effect of synbiotic supplementation on asprosin level in high fat diet-induced metabolic disorder in pregnant rats
  Mehrdad Naghizadeh, Mansour Karajibani, Hamed Fanaei, Farzaneh Montazerifar, Alireza Dashipour
  Mediterranean Journal of Nutrition and Metabolism.2022; 15(1): 81.     CrossRef
• Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats
  Rubiya Khursheed, Sachin Kumar Singh, Bimlesh Kumar, Sheetu Wadhwa, Monica Gulati, Anupriya A, Ankit Awasthi, Sukriti Vishwas, Jaskiran Kaur, Leander Corrie, Arya K.R., Rajan Kumar, Niraj Kumar Jha, Piyush Kumar Gupta, Flavia Zacconi, Kamal Dua, Nitin Chi
  International Journal of Pharmaceutics.2022; 612: 121306.     CrossRef
• Impact of synbiotic supplementation on cardiometabolic and anthropometric indices in patients with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials
  Seyyed Mostafa Arabi, Leila Sadat Bahrami, Iman Rahnama, Amirhossein Sahebkar
  Pharmacological Research.2022; 176: 106061.     CrossRef
• Susceptibility to Metabolic Diseases in COVID-19: To be or Not to be an Issue
  Maryam Kaviani, Somayeh Keshtkar, Saeede Soleimanian, Fatemeh Sabet Sarvestani, Negar Azarpira, Sara Pakbaz
  Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
• Mediating effects of gut microbiota in the associations of air pollutants exposure with adverse pregnancy outcomes
  Qiangsheng Gan, Weitao Ye, Xueqin Zhao, Yaoyao Teng, Shanshan Mei, Yan Long, Jun Ma, Rehemayi Rehemutula, Xiaoyan Zhang, Fangling Zeng, Hongmei Jin, Fei Liu, Yaogang Huang, Xiaoli Gao, Chunyan Zhu
  Ecotoxicology and Environmental Safety.2022; 234: 113371.     CrossRef
• Neurohormonal Changes in the Gut–Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery
  Eirini Martinou, Irena Stefanova, Evangelia Iosif, Angeliki M. Angelidi
  International Journal of Molecular Sciences.2022; 23(6): 3339.     CrossRef
• Gut microbiome and prostate cancer
  Kazutoshi Fujita, Makoto Matsushita, Eri Banno, Marco A De Velasco, Koji Hatano, Norio Nonomura, Hirotsugu Uemura
  International Journal of Urology.2022; 29(8): 793.     CrossRef
• Does Lactobacillus reuteri influence ergothioneine levels in the human body?
  Irwin K. Cheah, Jovan Z. Lee, Richard M. Y. Tang, Pei Wen Koh, Barry Halliwell
  FEBS Letters.2022; 596(10): 1241.     CrossRef
• Postbiotics as potential new therapeutic agents for metabolic disorders management
  Yasmina Bourebaba, Krzysztof Marycz, Malwina Mularczyk, Lynda Bourebaba
  Biomedicine & Pharmacotherapy.2022; 153: 113138.     CrossRef
• Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals
  Line Gaundal, Mari C. W. Myhrstad, Ida Rud, Terje Gjøvaag, Marte G. Byfuglien, Kjetil Retterstøl, Kirsten B. Holven, Stine M. Ulven, Vibeke H. Telle-Hansen
  Food & Nutrition Research.2022;[Epub]     CrossRef
• Xanthan gum oligosaccharides ameliorate glucose metabolism and related gut microbiota dysbiosis in type 2 diabetic mice
  Jingjing Xu, Wu Sun, Huan Li, Zexin Gao, Guoao Hu, Jianrong Wu, Hongtao Zhang, Zhitao Li, Minjie Gao, Li Zhu, Xiaobei Zhan
  Food Bioscience.2022; 50: 102002.     CrossRef
• Study and determination of fructan-type polysaccharide content in Erigeron annuus L
  Sergey Kovalev, A. Golovach, Vladimir Kovalev, Ewa Poleszak, Elshan Akhmedov, Olga Bobrytska
  Current Issues in Pharmacy and Medical Sciences.2022; 35(2): 95.     CrossRef
• Searching for a Link between Bone Decay and Diabetes Type 2
  Ciro G. Isacco, Kieu C.D. Nguyen, Van H. Pham, Gianna Di Palma, Sergey K. Aityan, Diego Tomassone, Pietro Distratis, Rita Lazzaro, Mario G. Balzanelli, Francesco Inchingolo
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(9): 904.     CrossRef
• Morchella esculenta mushroom polysaccharide attenuates diabetes and modulates intestinal permeability and gut microbiota in a type 2 diabetic mice model
  Ata Ur Rehman, Nimra Zafar Siddiqui, Nabeel Ahmed Farooqui, Gulzar Alam, Aneesa Gul, Bashir Ahmad, Muhammad Asim, Asif Iqbal Khan, Yi Xin, Wang Zexu, Hyo Song Ju, Wang Xin, Sun Lei, Liang Wang
  Frontiers in Nutrition.2022;[Epub]     CrossRef
• Bacillus subtilis-Fermented Amomum xanthioides Ameliorates Metabolic-Syndrome-Like Pathological Conditions in Long-Term HFHFD-Fed Mice
  Jing-Hua Wang, Seung-Ju Hwang, Kwang-Soo Shin, Dong-Woo Lim, Chang-Gue Son
  Antioxidants.2022; 11(11): 2254.     CrossRef
• Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet
  Yu Wang, Ting Li, Yueyue Liu, Chengcheng Yang, Lei Liu, Xiangnan Zhang, Xingbin Yang
  Food & Function.2022; 13(24): 13014.     CrossRef
• SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role
  Ahmad Ud Din, Maryam Mazhar, Muhammed Waseem, Waqar Ahmad, Asma Bibi, Adil Hassan, Niaz Ali, Wang Gang, Gao Qian, Razi Ullah, Tariq Shah, Mehraj Ullah, Israr Khan, Muhammad Farrukh Nisar, Jianbo Wu
  Biomedicine & Pharmacotherapy.2021; 133: 110947.     CrossRef
• Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota
  Faraz Bishehsari, Phillip A. Engen, Darbaz Adnan, Shahram Sarrafi, Sherry Wilber, Maliha Shaikh, Stefan J. Green, Ankur Naqib, Leila B. Giron, Mohamed Abdel-Mohsen, Ali Keshavarzian
  Translational Research.2021; 231: 113.     CrossRef
• The Multiomics Analyses of Fecal Matrix and Its Significance to Coeliac Disease Gut Profiling
  Sheeana Gangadoo, Piumie Rajapaksha Pathirannahalage, Samuel Cheeseman, Yen Thi Hoang Dang, Aaron Elbourne, Daniel Cozzolino, Kay Latham, Vi Khanh Truong, James Chapman
  International Journal of Molecular Sciences.2021; 22(4): 1965.     CrossRef
• Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models
  Maria Jose Carranza-Naval, Maria Vargas-Soria, Carmen Hierro-Bujalance, Gloria Baena-Nieto, Monica Garcia-Alloza, Carmen Infante-Garcia, Angel del Marco
  Biomolecules.2021; 11(2): 262.     CrossRef
• Effect of a Humanized Diet Profile on Colonization Efficiency and Gut Microbial Diversity in Human Flora-Associated Mice
  Sashuang Dong, BenHua Zeng, Ling Hu, Yuling Zhang, Jiaqi Xiong, Jing Deng, Liyan Huang, ZhenLin Liao, Jie Wang, Hong Wei, Xiang Fang
  Frontiers in Nutrition.2021;[Epub]     CrossRef
• Gut-Lung Axis in COVID-19
  Imane Allali, Youssef Bakri, Saaïd Amzazi, Hassan Ghazal, Mary E. Marquart
  Interdisciplinary Perspectives on Infectious Diseases.2021; 2021: 1.     CrossRef
• The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients
  Qiang Li, Fang Cheng, Qiling Xu, Yuyong Su, Xuefeng Cai, Fang Zeng, Yu Zhang
  International Immunopharmacology.2021; 95: 107531.     CrossRef
• Screening of Lactobacillus strains that enhance SCFA uptake in intestinal epithelial cells
  Da-wei Chen, Chun-meng Chen, Heng-xian Qu, Chen-yu Ren, Xian-tao Yan, Yu-jun Huang, Cheng-ran Guan, Chen-chen Zhang, Qi-ming Li, Rui-xia Gu
  European Food Research and Technology.2021; 247(5): 1049.     CrossRef
• Probiotics-rich emulsion improves insulin signalling in Palmitate/Oleate-challenged human hepatocarcinoma cells through the modulation of Fetuin-A/TLR4-JNK-NF-κB pathway
  Malwina Mularczyk, Yasmina Bourebaba, Anna Kowalczuk, Krzyzstof Marycz, Lynda Bourebaba
  Biomedicine & Pharmacotherapy.2021; 139: 111560.     CrossRef
• Metabolic profiles of oligosaccharides derived from four microbial polysaccharides by faecal inocula from type 2 diabetes patients
  Jingjing Xu, Weibao Liu, Jianrong Wu, Wen Wang, Zhuoping Wang, Xun Yu, Hongtao Zhang, Li Zhu, Xiaobei Zhan
  International Journal of Food Sciences and Nutrition.2021; 72(8): 1083.     CrossRef
• Using nanoselenium to combat Minamata disease in rats: the regulation of gut microbes
  Yang Liu, Wei Zhang, Jiating Zhao, Xiaoying Lin, Liming Wang, Liwei Cui, Junfang Zhang, Bai Li, Yu-Feng Li
  Environmental Science: Nano.2021; 8(5): 1437.     CrossRef
• Diabetes Mellitus’ta Mikrobiyotanın Rolü ve Hedeflenmesi
  Zinnet Şevval AKSOYALP, Cahit NACİTARHAN
  Turkish Journal of Diabetes and Obesity.2021; 5(1): 51.     CrossRef
• Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis
  Ye Yang, Yujun Long, Dongyu Kang, Chenchen Liu, Jingmei Xiao, Renrong Wu, Jingping Zhao
  Psychopharmacology.2021; 238(9): 2449.     CrossRef
• Epigenome – A mediator for host-microbiome crosstalk
  Robert C. Peery, Mohan Pammi, Erika Claud, Lanlan Shen
  Seminars in Perinatology.2021; 45(6): 151455.     CrossRef
• Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases
  Jing Xu, Yuejin Yang
  Gut Microbes.2021;[Epub]     CrossRef
• Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters
  Stefani A. Derrick, Aleksandra S. Kristo, Scott K. Reaves, Angelos K. Sikalidis
  International Journal of Environmental Research and Public Health.2021; 18(17): 9364.     CrossRef
• Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites
  Zhuye Jie, Suisha Liang, Qiuxia Ding, Fei Li, Xiaohuan Sun, Yuxiang Lin, Peishan Chen, Kaiye Cai, Hongcheng Zhou, Haorong Lu, Xiaohan Wang, Tao Zhang, Liang Xiao, Huanming Yang, Jian Wang, Yong Hou, Karsten Kristiansen, Huijue Jia, Xun Xu
  Medicine in Microecology.2021; 9: 100037.     CrossRef
• Lipid Metabolism, Disorders and Therapeutic Drugs - Review
  Vijayakumar Natesan, Sung-Jin Kim
  Biomolecules & Therapeutics.2021; 29(6): 596.     CrossRef
• Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
  Mahesh Raj Nepal, Mi Jeong Kang, Geon Ho Kim, Dong Ho Cha, Ju-Hyun Kim, Tae Cheon Jeong
  Diabetes & Metabolism Journal.2020; 44(6): 908.     CrossRef
• Dissecting genome-wide studies for microbiome-related metabolic diseases
  Denis Awany, Imane Allali, Emile R Chimusa
  Human Molecular Genetics.2020; 29(R1): R73.     CrossRef
• Gastrointestinal Disorders and Metabolic Syndrome: Dysbiosis as a Key Link and Common Bioactive Dietary Components Useful for their Treatment
  Anna De Filippis, Hammad Ullah, Alessandra Baldi, Marco Dacrema, Cristina Esposito, Emanuele Ugo Garzarella, Cristina Santarcangelo, Ariyawan Tantipongpiradet, Maria Daglia
  International Journal of Molecular Sciences.2020; 21(14): 4929.     CrossRef
• The public health rationale for increasing dietary fibre: Health benefits with a focus on gut microbiota
  F. Koç, S. Mills, C. Strain, R. P. Ross, C. Stanton
  Nutrition Bulletin.2020; 45(3): 294.     CrossRef
• Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin–nicotinamide-induced diabetic rats
  Kehinde S Olaniyi, Oluwatobi A Amusa, Emmanuel D Areola, Lawrence A Olatunji
  Experimental Biology and Medicine.2020; 245(7): 667.     CrossRef
• Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials
  Michał Wiciński, Jakub Gębalski, Jakub Gołębiewski, Bartosz Malinowski
  Microorganisms.2020; 8(8): 1148.     CrossRef
• Exploring role of probiotics and Ganoderma lucidum extract powder as solid carriers to solidify liquid self-nanoemulsifying delivery systems loaded with curcumin
  Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Ankit Awasthi, Rajan Kumar, Arya Kadukkattil Ramanunny, Bhupinder Kapoor, Pushpendra Kumar, Leander Corrie
  Carbohydrate Polymers.2020; 250: 116996.     CrossRef
• A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats
  Fuqiang Zhao, Qibing Liu, Jun Cao, Yunsheng Xu, Zhisheng Pei, Haofei Fan, Yiqiong Yuan, Xuanri Shen, Chuan Li
  Food and Chemical Toxicology.2020; 135: 110886.     CrossRef
• Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study
  Dong-Wook Park, Hyo Serk Lee, Myeong-Seung Shim, Kyu Jin Yum, Ju Tae Seo
  The World Journal of Men's Health.2020; 38(1): 95.     CrossRef
• Gut microbiota of obese and diabetic Thai subjects and interplay with dietary habits and blood profiles
  Lucsame Gruneck, Niwed Kullawong, Kongkiat Kespechara, Siam Popluechai
  PeerJ.2020; 8: e9622.     CrossRef
• Relationship Between the Gastrointestinal Side Effects of an Anti-Hypertensive Medication and Changes in the Serum Lipid Metabolome
  Yoomin Ahn, Myung Hee Nam, Eungbin Kim
  Nutrients.2020; 12(1): 205.     CrossRef
• Temporal and region-specific effects of sleep fragmentation on gut microbiota and intestinal morphology in Sprague Dawley rats
  Judy Triplett, David Ellis, Amber Braddock, Erin Roberts, Katherine Ingram, Eric Perez, Amanda Short, Dominique Brown, Victoria Hutzley, Chelsey Webb, Armando Soto, Victor Chan
  Gut Microbes.2020; 11(4): 706.     CrossRef
• Impact of probiotics and prebiotics targeting metabolic syndrome
  Douglas Xavier-Santos, Raquel Bedani, Egidio Dorea Lima, Susana Marta Isay Saad
  Journal of Functional Foods.2020; 64: 103666.     CrossRef
• Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model
  Dong Dai, Shu-geng Wu, Hai-jun Zhang, Guang-hai Qi, Jing Wang
  Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
• The possible role of a bacterial aspartate β-decarboxylase in the biosynthesis of alamandine
  Shalinee Jha, Robert C. Speth, Peter Macheroux
  Medical Hypotheses.2020; 144: 110038.     CrossRef
• Antibiotic-induced changes in the human gut microbiota for the most commonly prescribed antibiotics in primary care in the UK: a systematic review
  Karen T Elvers, Victoria J Wilson, Ashley Hammond, Lorna Duncan, Alyson L Huntley, Alastair D Hay, Esther T van der Werf
  BMJ Open.2020; 10(9): e035677.     CrossRef
• Microbiota Transplant in the Treatment of Obesity and Diabetes: Current and Future Perspectives
  Michael Napolitano, Mihai Covasa
  Frontiers in Microbiology.2020;[Epub]     CrossRef
• Maternal Microdeletion at the H19/Igf2 ICR in Mice Increases Offspring Susceptibility to In Utero Environmental Perturbation
  Anandita Pal, Judy Oakes, Marwa Elnagheeb, Folami Y Ideraabdullah
  Epigenetics Insights.2020;[Epub]     CrossRef
• Exploring the Triple Interaction between the Host Genome, the Epigenome, and the Gut Microbiome in Type 1 Diabetes
  Duaa Ahmed Elhag, Manoj Kumar, Souhaila Al Khodor
  International Journal of Molecular Sciences.2020; 22(1): 125.     CrossRef
• Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: A randomized controlled trial
  Nazila Kassaian, Awat Feizi, Ashraf Aminorroaya, Masoud Amini
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(5): 2991.     CrossRef
• The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study
  Yuling Dong, Hao Sun, Weichao Yang, Shuang Ma, Beibei Du, Hui Xu
  Nutrients.2019; 11(3): 636.     CrossRef
• Dietary wood pulp-derived sterols modulation of cholesterol metabolism and gut microbiota in high-fat-diet-fed hamsters
  Xiang Li, Huali Wang, Tianxin Wang, Fuping Zheng, Hao Wang, Chengtao Wang
  Food & Function.2019; 10(2): 775.     CrossRef
• Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study
  Tao Liu, Xiaojiao Chen, Yanjun Xu, Wei Wu, Wenli Tang, Zihui Chen, Guiyuan Ji, Jiewen Peng, Qi Jiang, Jianpeng Xiao, Xing Li, Weilin Zeng, Xiaojun Xu, Jianxiong Hu, Yuming Guo, Fei Zou, Qingfeng Du, Hongwei Zhou, Yan He, Wenjun Ma
  Environment International.2019; 130: 104882.     CrossRef
• A systematic literature review of the effect of anthocyanins on gut microbiota populations
  E. O. Igwe, K. E. Charlton, Y. C. Probst, K. Kent, M. E. Netzel
  Journal of Human Nutrition and Dietetics.2019; 32(1): 53.     CrossRef
• Selenium modulated gut flora and promoted decomposition of methylmercury in methylmercury-poisoned rats
  Yang Liu, Jun Ji, Wei Zhang, Yao Suo, Jiating Zhao, Xiaoying Lin, Liwei Cui, Bai Li, Huaiqiang Hu, Chunying Chen, Yu-Feng Li
  Ecotoxicology and Environmental Safety.2019; 185: 109720.     CrossRef
• Modulation of Gut Microbiota by Soybean 7S Globulin Peptide That Involved Lipopolysaccharide–Peptide Interaction
  Kaining Han, Danyang Luo, Yuan Zou, Shiyuan Dong, Zhili Wan, Xiaoquan Yang
  Journal of Agricultural and Food Chemistry.2019; 67(8): 2201.     CrossRef
• The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology
  Hui Yun Penny Oh, Vivegan Visvalingam, Walter Wahli
  The FASEB Journal.2019; 33(9): 9706.     CrossRef
• Quorum sensing inhibitors as antipathogens: biotechnological applications
  Vipin Chandra Kalia, Sanjay K.S. Patel, Yun Chan Kang, Jung-Kul Lee
  Biotechnology Advances.2019; 37(1): 68.     CrossRef
• Bacillus subtilis 29784 induces a shift in broiler gut microbiome toward butyrate-producing bacteria and improves intestinal histomorphology and animal performance
  V. Jacquier, A. Nelson, M. Jlali, L. Rhayat, K.S. Brinch, E. Devillard
  Poultry Science.2019; 98(6): 2548.     CrossRef
• The alteration of gut microbiota in newly diagnosed type 2 diabetic patients
  Pei-Chi Chen, Yi-Wen Chien, Suh-Ching Yang
  Nutrition.2019; 63-64: 51.     CrossRef
• Mechanisms of Action of Probiotics
  Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Mercedes Gil-Campos, Angel Gil
  Advances in Nutrition.2019; 10: S49.     CrossRef
• Decrease in αβ/γδ T‐cell ratio is accompanied by a reduction in high‐fat diet‐induced weight gain, insulin resistance, and inflammation
  Gwenaëlle Le Menn, Brigitte Sibille, Joseph Murdaca, Anne-Sophie Rousseau, Raphaëlle Squillace, Bastien Vergoni, Mireille Cormont, Isabelle Niot, Paul A. Grimaldi, Isabelle Mothe-Satney, Jaap G. Neels
  The FASEB Journal.2019; 33(2): 2553.     CrossRef
• Akkermansia muciniphila is a new universal probiotic on the basis of live human commensal gut bacteria: the reality or legend?
  B. A. Shenderov, S. M. Yudin, A. V. Zagaynova, M. P. Shevyreva
  Journal of microbiology, epidemiology and immunobiology.2019; 96(4): 105.     CrossRef
• Dietary metabolism, the gut microbiome, and heart failure
  W. H. Wilson Tang, Daniel Y. Li, Stanley L. Hazen
  Nature Reviews Cardiology.2019; 16(3): 137.     CrossRef
• Probiotic properties of Lactobacillus strains from traditional fermented yogurt in Xinjiang
  Ruokun Yi, Fang Tan, Xin Zhao, Z.B. Xu, D.Q. Chen, J.Y. Liu
  E3S Web of Conferences.2019; 131: 01121.     CrossRef
• Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives
  Adriana Florinela Cӑtoi, Dan Cristian Vodnar, Andreea Corina, Dragana Nikolic, Roberto Citarrella, Pablo Pérez-Martínez, Manfredi Rizzo
  Current Pharmaceutical Design.2019; 25(18): 2038.     CrossRef
• Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity
  Mary Jane West-Eberhard
  Proceedings of the National Academy of Sciences.2019; 116(3): 723.     CrossRef
• Impact of intestinal microbiota in patients with heart failure: A systematic review
  Francesc Formiga, Cristiana Isabel Ferreira Teles, David Chivite
  Medicina Clínica (English Edition).2019; 153(10): 402.     CrossRef
• Impacto de la microbiota intestinal en los pacientes con insuficiencia cardíaca: revisión sistemática
  Francesc Formiga, Cristiana Isabel Ferreira Teles, David Chivite
  Medicina Clínica.2019; 153(10): 402.     CrossRef
• Additional Effect of Dietary Fiber in Patients with Type 2 Diabetes Mellitus Using Metformin and Sulfonylurea: An Open-Label, Pilot Trial
  Seung-Eun Lee, Yongbin Choi, Ji Eun Jun, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gwang Pyo Ko, Moon-Kyu Lee
  Diabetes & Metabolism Journal.2019; 43(4): 422.     CrossRef
• Human Milk Oligosaccharides and Immune System Development
  Julio Plaza-Díaz, Luis Fontana, Angel Gil
  Nutrients.2018; 10(8): 1038.     CrossRef
• Oil tea improves glucose and lipid levels and alters gut microbiota in type 2 diabetic mice
  Rui Lin, Xuan He, Huafeng Chen, Qin He, Ziting Yao, Yuanfan Li, Hui Yang, Steve Simpson
  Nutrition Research.2018; 57: 67.     CrossRef
• The journey of gut microbiome – An introduction and its influence on metabolic disorders
  Ankita Chattopadhyay, S. Mythili
  Frontiers in Biology.2018; 13(5): 327.     CrossRef
• The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into “Old” Diseases
  Igor Alexander Harsch, Peter Christopher Konturek
  Medical Sciences.2018; 6(2): 32.     CrossRef
• Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications
  Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase
  Journal of Diabetes Research.2018; 2018: 1.     CrossRef
• An alternative storage method for characterization of the intestinal microbiota through next generation sequencing
  Roberto Marques Ribeiro, Marcela de Souza-Basqueira, Léa Campos de Oliveira, Flavia Cristina Salles, Natalia Bueno Pereira, Ester Cerdeira Sabino
  Revista do Instituto de Medicina Tropical de São Paulo.2018;[Epub]     CrossRef
• Dietary fibers, prebiotics, and exopolysaccharides produced by lactic acid bacteria: potential health benefits with special regard to cholesterol-lowering effects
  E. Korcz, Z. Kerényi, L. Varga
  Food & Function.2018; 9(6): 3057.     CrossRef
• Intestinal Bacterial Flora and Alzheimer’s Disease
  M. Bostanciklioğlu
  Neurophysiology.2018; 50(2): 140.     CrossRef
• Capsaicin in Metabolic Syndrome
  Sunil K. Panchal, Edward Bliss, Lindsay Brown
  Nutrients.2018; 10(5): 630.     CrossRef
• Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut
  Ajay Kumar Jain, Carel W. le Roux, Puneet Puri, Ali Tavakkoli, Nana Gletsu‐Miller, Blandine Laferrère, Richard Kellermayer, John K. DiBaise, Robert G. Martindale, Bruce M. Wolfe
  Journal of Parenteral and Enteral Nutrition.2018; 42(2): 279.     CrossRef
• Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial
  Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Yan Zheng, Catherine M. Champagne, George A. Bray, Frank M. Sacks, Lu Qi
  International Journal of Obesity.2018; 42(9): 1565.     CrossRef
• Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice
  Siyu Chen, Xiao Li, Li Liu, Chang Liu, Xiao Han
  The FASEB Journal.2018; 32(3): 1139.     CrossRef
• Differences in intestinal microflora and metabolites between patients with schizophrenia, depression, bipolar disorder, and healthy subjects: protocol for a case-control study
  Yi-Huan Chen, Zheng-Wu Peng, Xuan Zhang, Jie Bai, Shou-Fen Yu, Xiao-Sa Li, Xiao-Ling Qiang, Ping Zhou, Hong He, Hua-Ning Wang
  Asia Pacific Journal of Clinical Trials: Nervous System Diseases.2018; 3(3): 120.     CrossRef
• Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
  David Ma, Amy C. Wang, Ishita Parikh, Stefan J. Green, Jared D. Hoffman, George Chlipala, M. Paul Murphy, Brent S. Sokola, Björn Bauer, Anika M. S. Hartz, Ai-Ling Lin
  Scientific Reports.2018;[Epub]     CrossRef
• Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes
  Xinpu Chen, Sridevi Devaraj
  Current Diabetes Reports.2018;[Epub]     CrossRef
• Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism
  Juan Liu, Shijun Yue, Zhirui Yang, Wuwen Feng, Xintong Meng, Aiting Wang, Cheng Peng, Changyun Wang, Dan Yan
  Pharmacological Research.2018; 134: 40.     CrossRef
• Nutrients and Oxidative Stress: Friend or Foe?
  Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew, Rodrigo Valenzuela
  Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
• Fäkaler Mikrobiomtransfer
  C. Lübbert, B. Salzberger, J. Mössner
  Der Internist.2017; 58(5): 456.     CrossRef
• Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases
  Xuan Li, Keita Watanabe, Ikuo Kimura
  Frontiers in Immunology.2017;[Epub]     CrossRef
• Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment
  Giorgia Spaggiari, Giulia Brigante, Sara De Vincentis, Umberto Cattini, Laura Roli, Maria Cristina De Santis, Enrica Baraldi, Simonetta Tagliavini, Manuela Varani, Tommaso Trenti, Vincenzo Rochira, Manuela Simoni, Daniele Santi
  Frontiers in Endocrinology.2017;[Epub]     CrossRef
• Microbiota manipulation for weight change
  Tal Dror, Yaakov Dickstein, Grégory Dubourg, Mical Paul
  Microbial Pathogenesis.2017; 106: 146.     CrossRef
• Prevention and treatment of cancer targeting chronic inflammation: research progress, potential agents, clinical studies and mechanisms
  Yong Zhang, Weijia Kong, Jiandong Jiang
  Science China Life Sciences.2017; 60(6): 601.     CrossRef
• Gut Microbiota in Health and Probiotics in Functional Bowel Disease
  Jai Hyun Rhyou
  The Ewha Medical Journal.2017; 40(1): 22.     CrossRef
• Effects of mutation of Asn694 in Aspergillus niger α-glucosidase on hydrolysis and transglucosylation
  Min Ma, Masayuki Okuyama, Megumi Sato, Takayoshi Tagami, Patcharapa Klahan, Yuya Kumagai, Haruhide Mori, Atsuo Kimura
  Applied Microbiology and Biotechnology.2017; 101(16): 6399.     CrossRef
• A Fermented Whole Grain Prevents Lipopolysaccharides‐Induced Dysfunction in Human Endothelial Progenitor Cells
  Laura Giusti, Morena Gabriele, Giuseppe Penno, Monia Garofolo, Vincenzo Longo, Stefano Del Prato, Daniela Lucchesi, Laura Pucci, Grant N. Pierce
  Oxidative Medicine and Cellular Longevity.2017;[Epub]     CrossRef
• What Bariatric Surgery Can Teach Us About Endoluminal Treatment of Obesity and Metabolic Disorders
  Lee M. Kaplan
  Gastrointestinal Endoscopy Clinics of North America.2017; 27(2): 213.     CrossRef
• An Extracellular Cell-Attached Pullulanase Confers Branched α-Glucan Utilization in Human Gut Lactobacillus acidophilus
  Marie S. Møller, Yong Jun Goh, Kasper Bøwig Rasmussen, Wojciech Cypryk, Hasan Ufuk Celebioglu, Todd R. Klaenhammer, Birte Svensson, Maher Abou Hachem, Patrick D. Schloss
  Applied and Environmental Microbiology.2017;[Epub]     CrossRef
• Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis and Glucose Intolerance in Association with Gut Microbiota Modulation
  Na R. Shin, Shambhunath Bose, Jing-Hua Wang, AbuZar Ansari, Soo-Kyoung Lim, Young-won Chin, Han-seok Choi, Hojun Kim
  Frontiers in Microbiology.2017;[Epub]     CrossRef
• Preserved Gut Microbial Diversity Accompanies Upregulation of TGR5 and Hepatobiliary Transporters in Bile Acid–Treated Animals Receiving Parenteral Nutrition
  Ajay Kumar Jain, Abhineet Sharma, Sumit Arora, Keith Blomenkamp, Ik Chan Jun, Robert Luong, David John Westrich, Aayush Mittal, Paula M. Buchanan, Miguel A. Guzman, John Long, Brent A. Neuschwander‐Tetri, Jeffery Teckman
  Journal of Parenteral and Enteral Nutrition.2017; 41(2): 198.     CrossRef
• Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics
  Mingqian He, Bingyin Shi
  Cell & Bioscience.2017;[Epub]     CrossRef
• Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D
  Kenneth K. Barfod, Michael Roggenbuck, Suzan Al-Shuweli, Dalia Fakih, Søren J. Sørensen, Grith L. Sørensen
  Heliyon.2017; 3(3): e00262.     CrossRef
• Gut microbiota: its development and relation to certain diseases
  Hana Kiňová Sepová, Boris Dudík, Andrea Bilková
  Česká a slovenská farmacie.2017; 66(6): 267.     CrossRef
• Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals
  Sabri Rial, Antony Karelis, Karl-F. Bergeron, Catherine Mounier
  Nutrients.2016; 8(5): 281.     CrossRef
• Emerging Technologies for Gut Microbiome Research
  Jason W. Arnold, Jeffrey Roach, M. Andrea Azcarate-Peril
  Trends in Microbiology.2016; 24(11): 887.     CrossRef
• Network-Thinking: Graphs to Analyze Microbial Complexity and Evolution
  Eduardo Corel, Philippe Lopez, Raphaël Méheust, Eric Bapteste
  Trends in Microbiology.2016; 24(3): 224.     CrossRef
• Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota
  Blanca S. Noriega, Marcos A. Sanchez-Gonzalez, Daria Salyakina, Jonathan Coffman
  Case Reports in Medicine.2016; 2016: 1.     CrossRef
• Human Microbiome and its Association With Health and Diseases
  Asmaa A. Althani, Hany E. Marei, Wedad S. Hamdi, Gheyath K. Nasrallah, Mohamed E. El Zowalaty, Souhaila Al Khodor, Maha Al-Asmakh, Hassan Abdel-Aziz, Carlo Cenciarelli
  Journal of Cellular Physiology.2016; 231(8): 1688.     CrossRef
• Redefining Healthy Urine: A Cross-Sectional Exploratory Metagenomic Study of People With and Without Bladder Dysfunction
  Suzanne L. Groah, Marcos Pérez-Losada, Ljubica Caldovic, Inger H. Ljungberg, Bruce M. Sprague, Eduardo Castro-Nallar, Neel J. Chandel, Michael H. Hsieh, Hans G. Pohl
  Journal of Urology.2016; 196(2): 579.     CrossRef
• Sasa quelpaertensis leaf extract regulates microbial dysbiosis by modulating the composition and diversity of the microbiota in dextran sulfate sodium-induced colitis mice
  Yiseul Yeom, Bong-Soo Kim, Se-Jae Kim, Yuri Kim
  BMC Complementary and Alternative Medicine.2016;[Epub]     CrossRef
• Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes
  Theresa D'Aquila, Yu-Han Hung, Alicia Carreiro, Kimberly K. Buhman
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2016; 1861(8): 730.     CrossRef
• The Janus-Face of Bacteriophages across Human Body Habitats
  Adam Wahida, Klaus Ritter, Hans-Peter Horz, James B. Bliska
  PLOS Pathogens.2016; 12(6): e1005634.     CrossRef
• Obesity and Cancer—Opportunities to Break the Link
  Daniel F. Argolo, Clifford A. Hudis, Neil M. Iyengar
  Current Breast Cancer Reports.2016; 8(1): 22.     CrossRef
• Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds
  Meng Li, Xiangbing Shu, Hanchen Xu, Chunlei Zhang, Lili Yang, Li Zhang, Guang Ji
  Journal of Translational Medicine.2016;[Epub]     CrossRef
• Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome
  Lukasz Kaska, Tomasz Sledzinski, Agnieszka Chomiczewska, Agnieszka Dettlaff-Pokora, Julian Swierczynski
  World Journal of Gastroenterology.2016; 22(39): 8698.     CrossRef
• Fäkale Mikrobiotatransplantation (FMT)
  C. Lübbert
  Der Diabetologe.2016; 12(6): 409.     CrossRef
• Metformin and the gastrointestinal tract
  Laura J. McCreight, Clifford J. Bailey, Ewan R. Pearson
  Diabetologia.2016; 59(3): 426.     CrossRef
• Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats
  Julie Reygner, Lydia Lichtenberger, Ghada Elmhiri, Samir Dou, Narges Bahi-Jaber, Larbi Rhazi, Flore Depeint, Veronique Bach, Hafida Khorsi-Cauet, Latifa Abdennebi-Najar, Hauke Smidt
  PLOS ONE.2016; 11(10): e0164614.     CrossRef
• The human gut microbiome in health: establishment and resilience of microbiota over a lifetime
  Kacy Greenhalgh, Kristen M. Meyer, Kjersti M. Aagaard, Paul Wilmes
  Environmental Microbiology.2016; 18(7): 2103.     CrossRef
• Surgical Management of Metabolic Syndrome Related to Morbid Obesity
  Scott T. Rehrig
  Primary Care: Clinics in Office Practice.2016; 43(1): 145.     CrossRef
• Dietary silver nanoparticles can disturb the gut microbiota in mice
  Sybille van den Brule, Jérôme Ambroise, Hélène Lecloux, Clément Levard, Romain Soulas, Pieter-Jan De Temmerman, Mihaly Palmai-Pallag, Etienne Marbaix, Dominique Lison
  Particle and Fibre Toxicology.2015;[Epub]     CrossRef
• Probiotics as Complementary Treatment for Metabolic Disorders
  Mélanie Le Barz, Fernando F. Anhê, Thibaut V. Varin, Yves Desjardins, Emile Levy, Denis Roy, Maria C. Urdaci, André Marette
  Diabetes & Metabolism Journal.2015; 39(4): 291.     CrossRef
• Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk
  Luca Miele, Valentina Giorgio, Maria Adele Alberelli, Erica De Candia, Antonio Gasbarrini, Antonio Grieco
  Current Cardiology Reports.2015;[Epub]     CrossRef
• Disease Prevention and Health Promotion
  Ather Ali, David L. Katz
  American Journal of Preventive Medicine.2015; 49(5): S230.     CrossRef
• Creating Healthier Microbiomes, from Conception to Childhood: A Clinical Conversation with Geeta Maker-Clark, MD, and Robert Rountree, MD
  
  Alternative and Complementary Therapies.2015; 21(5): 189.     CrossRef
• Prebiotic consumption and the incidence of overweight in a Mediterranean cohort: the Seguimiento Universidad de Navarra Project
  Aurora Perez-Cornago, Miguel A Martinez-Gonzalez, Miguel Ruiz-Canela, Ignacio Jaurrieta, Silvia Carlos, Carmen Sayon-Orea, Maira Bes-Rastrollo
  The American Journal of Clinical Nutrition.2015; 102(6): 1554.     CrossRef

About this article

Hur KY, Lee MS. Gut Microbiota and Metabolic Disorders. Diabetes Metab J. 2015;39(3):198-203.

DOI: https://doi.org/10.4093/dmj.2015.39.3.198.

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