Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 38(6); 2014 > Article
Letter
Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J 2014;38:375-87)
Soo Heon Kwak
Diabetes & Metabolism Journal 2014;38(6):484-486.
DOI: https://doi.org/10.4093/dmj.2014.38.6.484
Published online: December 15, 2014
  • 3,262 Views
  • 34 Download

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

corresp_icon Corresponding author: Soo Heon Kwak. Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. shkwak@snu.ac.kr

Copyright © 2014 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

prev next
Type 2 diabetes is a multigenic disorder where genetic and environmental factors and their interactions play crucial roles in the pathogenesis. The recent technological advancement in genome analyses enabled us to identify at least 70 genetic loci for type 2 diabetes [1,2]. Collaborative efforts led by Korea National Institute of Health have laid the basis for the Asian Genetic Epidemiology Consortium and have identified eight novel genetic variants associated with type 2 diabetes in more than 54,000 East Asians subjects including Korean, Chinese, Japanese, Taiwanese, and Singaporeans [3].
The article entitled "Genome-wide association study identifies two novel Loci with sex-specific effects for type 2 diabetes mellitus and glycemic traits in a korean population" [4] is a two staged genome-wide association study on type 2 diabetes in a Korean population. In this study, the authors investigated more than 4.5 million genotyped and imputed single nucleotide polymorphisms to identify genetic risk factors for type 2 diabetes. The authors found that genetic variants in or near CDKAL1 (rs7754840) and CDKN2A/2B (rs10811661) genes are associated with diabetes with odds ratio of 1.30 and 1.29, respectively, at genome-wide significance level of P<5.0×10-8. These two variants are also strong genetic risk factors in Europeans and other population, which suggests that genetic risk factors are shared across ethnicities [5]. The novel finding of this study is the association between variants in CCDC63 (rs11065756) and C12orf51 (rs2074356) with the risk of type 2 diabetes.
This study deserves much attention as it provides detailed information on genetic risk factors of type 2 diabetes in Koreans. However, it should be clarified whether the novel genetic association between variants in CCDC63 and C12orf51 and type 2 diabetes is confounded by alcohol consumption. In a previous study using the same discovery set, the very same variants (rs11065756 in CCDC63 and rs2074356 in C12orf51) were significantly associated with alcohol consumption [6]. When the direction of association is considered, it is also true that alleles associated with increased risk of diabetes are associated with increased alcohol consumption. The fact that the association of these two variants with type 2 diabetes was only specific to men is also true for alcohol consumption. It could be possible that the variants have pleiotropic effect and are associated with both alcohol consumption and type 2 diabetes in an independent manner. This could be clarified by reanalyzing the data with an adjustment to the amount of alcohol consumption.

No potential conflict of interest relevant to this article was reported.

  • 1. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segre AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Bostrom K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jorgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proenca C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparso T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI. MAGIC investigators. GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589. ArticlePubMedPMCPDF
  • 2. Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Muller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ, Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR, Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stancakova A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutskov K, Langford C, Leander K, Lindholm E, Lobbens S, Mannisto S, Mirza G, Muhleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurdsson G, Silveira A, Steinbach G, Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C, Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi NG, Syvanen AC, Eriksson JG, Peltonen L, Nothen MM, Balkau B, Palmer CN, Lyssenko V, Tuomi T, Isomaa B, Hunter DJ, Qi L. Wellcome Trust Case Control Consortium. Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators. Genetic Investigation of ANthropometric Traits (GIANT) Consortium. Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium. South Asian Type 2 Diabetes (SAT2D) Consortium. ShuldinerAR. RodenM. BarrosoI. WilsgaardT. BeilbyJ. HovinghK. PriceJF. WilsonJF. RauramaaR. LakkaTA. LindL. DedoussisG. NjolstadI. PedersenNL. KhawKT. WarehamNJ. Keinanen-KiukaanniemiSM. SaaristoTE. Korpi-HyovaltiE. SaltevoJ. LaaksoM. KuusistoJ. MetspaluA. CollinsFS. MohlkeKL. BergmanRN. TuomilehtoJ. BoehmBO. GiegerC. HveemK. CauchiS. FroguelP. BaldassarreD. TremoliE. HumphriesSE. SaleheenD. DaneshJ. IngelssonE. RipattiS. SalomaaV. ErbelR. JockelKH. MoebusS. PetersA. IlligT. de FaireU. HamstenA. MorrisAD. DonnellyPJ. FraylingTM. HattersleyAT. BoerwinkleE. MelanderO. KathiresanS. NilssonPM. DeloukasP. ThorsteinsdottirU. GroopLC. StefanssonK. HuF. PankowJS. DupuisJ. MeigsJB. AltshulerD. BoehnkeM. McCarthyMI. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;44:981-990. ArticlePubMedPMCPDF
  • 3. Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman AK, Morris AP, McCarthy MI; DIAGRAM Consortium; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 2011;44:67-72. ArticlePubMedPMCPDF
  • 4. Go MJ, Hwang JY, Park TJ, Kim YJ, Oh JH, Kim YJ, Han BG, Kim BJ. Genome-wide association study identifies two novel Loci with sex-specific effects for type 2 diabetes mellitus and glycemic traits in a korean population. Diabetes Metab J 2014;38:375-387. ArticlePubMedPMC
  • 5. Cho YS, Lee JY, Park KS, Nho CW. Genetics of type 2 diabetes in East Asian populations. Curr Diab Rep 2012;12:686-696. ArticlePubMedPDF
  • 6. Baik I, Cho NH, Kim SH, Han BG, Shin C. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. Am J Clin Nutr 2011;93:809-816. ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  

      • PubReader PubReader
      • Cite this Article
        Cite this Article
        export Copy Download
        Close
        Download Citation
        Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

        Format:
        • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
        • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
        Include:
        • Citation for the content below
        Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J 2014;38:375-87)
        Diabetes Metab J. 2014;38(6):484-486.   Published online December 15, 2014
        Close
      • XML DownloadXML Download
      Related articles
      Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J 2014;38:375-87)
      Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J 2014;38:375-87)
      Kwak SH. Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J 2014;38:375-87). Diabetes Metab J. 2014;38(6):484-486.
      DOI: https://doi.org/10.4093/dmj.2014.38.6.484.

      Diabetes Metab J : Diabetes & Metabolism Journal
      Close layer
      TOP