Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 38(2); 2014 > Article
Response
Response: Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus (Diabetes Metab J 2013;37:423-8)
Jin Hwa Kim, Hak Yeon Bae, Sang Yong Kim
Diabetes & Metabolism Journal 2014;38(2):160-161.
DOI: https://doi.org/10.4093/dmj.2014.38.2.160
Published online: April 18, 2014
  • 3,320 Views
  • 30 Download
  • 5 Web of Science
  • 5 Crossref
  • 8 Scopus

Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea.

Corresponding author: Sang Yong Kim. Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University School of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Korea. diabetes@chosun.ac.kr

Copyright © 2014 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

We truly appreciate the interest and comments regarding our article, "Clinical marker of platelet hyperreactivity in diabetes mellitus," which was published in Diabetes & Metabolism Journal [1]. Our responses to the comments by Drs. Cengiz Beyan and Esin Beyan's are as follows:
We suggested that mean platelet volume (MPV), which is used to measure platelet size, is a potential marker of platelet hyperreactivity in diabetes. Although some uncertainty remain, previous studies have also shown that MPV is a potential predictive marker of platelet hyperreactivity in diabetes [2,3,4,5]. Furthermore, Shah et al. [6] reported a significant correlation between MPV and the degree of glycemic control only in diabetic patients. They suggested that the positive relationship between an increased glucose level and increased MPV is a unique phenomenon of diabetes. Recent data from our group supports this possibility. We found a contrasting relationship between MPV and fasting plasma glucose in the presence and absence of diabetes in a general Korean population [7]. Nevertheless, we think that further large prospective studies should be conducted to confirm the clinical utility of this marker and to clarify the association between MPV and platelet hyperreactivity in diabetes.
We agree with you about the correct measurement of MPV. There is a need for careful measurements and interpretation. However, current various methods that are used to measure platelet function are mostly complex and are not easily applicable in real clinical practice. On the other hand, although there are controversies about the most exact methodology for measuring MPV, it is easily accessible in the inpatient and outpatient settings at a relatively low cost. For this reason we believe that bolstering the strengths to make up for the weaknesses may provide an alternative route for better diagnosis, but further studies are still required.
Thank you for your interest in this article and for your thoughtful comments.

No potential conflict of interest relevant to this article was reported.

  • 1. Kim JH, Bae HY, Kim SY. Clinical marker of platelet hyperreactivity in diabetes mellitus. Diabetes Metab J 2013;37:423-428. ArticlePubMedPMC
  • 2. Unubol M, Ayhan M, Guney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012;23:475-480. ArticlePubMed
  • 3. Tavil Y, Sen N, Yazici H, Turfan M, Hizal F, Cengel A, Abaci A. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets 2010;21:368-372. ArticlePubMed
  • 4. Park BJ, Shim JY, Lee HR, Jung DH, Lee JH, Lee YJ. The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences. Platelets 2012;23:45-50. ArticlePubMed
  • 5. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58. ArticlePubMed
  • 6. Shah B, Sha D, Xie D, Mohler ER 3rd, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health and Nutrition Examination Survey, 1999-2004. Diabetes Care 2012;35:1074-1078. PubMedPMC
  • 7. Kim JH, Kang SB, Kang JI, Kim JW, Kim SY, Bae HY. The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean general population: gender differences. Platelets 2013;24:469-473. ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • The unique association between the level of plateletcrit and the prevalence of diabetic kidney disease: a cross-sectional study
      Shuwu Wei, Xinyu Pan, Yao Xiao, Ruishuang Chen, Junping Wei
      Frontiers in Endocrinology.2024;[Epub]     CrossRef
    • Impact of Uncontrolled Diabetes Mellitus on Blood Cells Indices and Plasma Components in Patients Without Nephropathy
      Hisham Ali Waggiallah, Hala Elsir Khair, Rania Saad Suliman, Humood Al Shmrany, Elturabi Elsayed Elkhider, Mudathir Mohamed Ahmed Eltayeb, Nermen Abdelftah Mohamed Ma, Yousif Mohammed Elmosaad
      Pakistan Journal of Biological Sciences.2023; 26(5): 279.     CrossRef
    • Effects of statin therapy on mean platelet volume in patients with risk of cardiovascular diseases: a systematic review and meta-analysis
      Shuaifei Ji, Babo Zhang, Xianda Wang, Heng Shi, Lixin Yu, Xiaocheng Wang
      Bioscience Reports.2019;[Epub]     CrossRef
    • The relationship between mean platelet volume and diabetic retinopathy: a systematic review and meta-analysis
      ShuaiFei Ji, Jie Zhang, XiuDe Fan, XiQiang Wang, XiaoNa Ning, BaBo Zhang, Heng Shi, Hong Yan
      Diabetology & Metabolic Syndrome.2019;[Epub]     CrossRef
    • Platelets volume indexes and cardiovascular risk factors
      Thaís Resende Batista, Roberta Carvalho de Figueiredo, Danyelle Romana Alves Rios
      Revista da Associação Médica Brasileira.2018; 64(6): 554.     CrossRef

    • PubReader PubReader
    • Cite this Article
      Cite this Article
      export Copy Download
      Close
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

      Format:
      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      Include:
      • Citation for the content below
      Response: Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus (Diabetes Metab J 2013;37:423-8)
      Diabetes Metab J. 2014;38(2):160-161.   Published online April 18, 2014
      Close
    • XML DownloadXML Download
    Related articles
    Kim JH, Bae HY, Kim SY. Response: Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus (Diabetes Metab J 2013;37:423-8). Diabetes Metab J. 2014;38(2):160-161.
    DOI: https://doi.org/10.4093/dmj.2014.38.2.160.

    Diabetes Metab J : Diabetes & Metabolism Journal
    Close layer