Abstract

The purpose of the preserit rcport is to analyse the significance of the insulin response and the insulinogenic index to oral glucose loads in normal and diabetic subjects. In this study, plasma insulin was determined by means of radioimmunonssay and insulinogenic index was obtaineel by dividing plasma insulin enhancement above fasting value be corresponding net of increase of blood glucose in 116 patients, The one hundred-sixteen patients included 13 nonobese and 7 obese normal subject:.36 nobese and 18 obese maderate diabetic patient and 42 severe. Diabetic patients. The results were as follows: 1)The plasma insulin level in l3 nonobese normal subjects were 14.0+-2. 8, 44.9+- 7.5, 37.9 +-5.1, and 24.8+- 3.2,U/ml (Mean +- S.E.) at fasting staie and at .30, 60, 90, and 120 min after oral glucose load, with a peak value at. 30. Min. 2) in 7 obese normal subjects the plasma insulin concentratiorn were 32. 7 +-8. 6. 81.8+-15.4, 74.8+-15.0. 53.0+-12.7 and 46.3+- 10.8pU/ml which were greater responses than nonobese ones. 3), ln 36 nonobes moderate diabetics patient. The plasma insulin were 19.8 +-2,2 ,39.5+- 2.6, 42.9+-3.3, 39.8+-4.2 and 29.8+-4.0 ,U/ml. There were little significance compared to nonobese normal control but slighitly delayed response was demonstrated. 4) Theplasma insulin concentration in 8 obese moderated dlabetics were 22.3+-2.8, 73.2+-11.0, 94.8 +-14.7, 60.5+-8, and 50.8+-5.8 'U/ml with greater than that of nonobese moderate dlabetics. 5) In 42 severe dlabetic subjects, plasma insulin level were 6.8+-1.0, 12.2+-1.1, 15.5+-1.4, 14.9+-1.8 and 11.5+-0.2,U/ml with significantly reduced response. 6) The inisuinogenie index at 30,60,90 and 120 min after glucose loads were 0.65+-0.11, 0.67+-0.17 ,0.93+-0.20 and 1.27 +- 0.20, in nonobse normal subjects, 0.22+-0.03, 0.23+-0.03, 0.21+-0.03 and in nonobse moderate diabetic and 0.05+- 0 01. 0.08+-0.01. 0.06+-0.01 and 0.06+-0.01 in severe diabetics. There were significant differnces between each groups of patient of patients magnitude of insulngenic index regardles of body weight especially at 90 min.