Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 32(6); 2008 > Article
Original Article Effect of Valsartan on Blood Pressure and Urinary Albumin Excretion in Hypertensive Type 2 Diabetic Patients: An Open-Label, Multicenter Study.
Se Jun Park, Dae Jung Kim, Hae Jin Kim, Soo Yeon Park, Ji A Seo, Nan Hee Kim, Sung Hee Choi, Soo Lim, Hak Chul Jang, Seung Hyun Ko, Ki Ho Song, Yu Bae Ahn, Soo Kyoung Kim, Yong Wook Cho, Jun Goo Kang, Sung Hee Ihm, Cheol Young Park, Sung Woo Park, Dong Hyun Shin, Yong Hyun Kim, Kwan Woo Lee
Diabetes & Metabolism Journal 2008;32(6):513-521
DOI: https://doi.org/10.4093/kdj.2008.32.6.513
Published online: December 1, 2008
  • 2,334 Views
  • 25 Download
  • 0 Crossref
  • 0 Scopus
1Department of Endocrinology and Metabolism, Ajou University School of Medicine, Korea.
2Department of Internal Medicine, Korea University College of Medicine, Korea.
3Seoul National University College of Medicine, Seoul National University Bundang Hospital, Korea.
4Department of Internal Medicine, Catholic University College of Medicine, Korea.
5Department of Internal Medicine, Pochon CHA University, Korea.
6Department of Internal Medicine, Hallym University College of Medicine, Korea.
7Department of Internal Medicine, Sungkyunkwan University School of Medicine, Korea.
8Department of Internal Medicine, Bundang Jesaeng General Hospital, Korea.

BACKGROUND
Activation of renin-angiotensin system (RAS) has been an important mechanism of microvascular and macrovascular complications in diabetic patients. It has been reported that RAS blockades reduce the development and progression of diabetic nephropathy. The aim of this study was to evaluate whether valsartan, an angiotensin II receptor blocker (ARB), reduced blood pressure and urinary albumin excretion rate (UAER) in hypertensive type 2 diabetic patients. METHOD: Three hundred forty-seven hypertensive type 2 diabetic patients who had not taken angiotensin converting enzyme inhibitors or ARB for 6 months prior to this study were enrolled. We measured blood pressure and UAER before and after 24 weeks of valsartan treatment. RESULT: Baseline mean systolic and diastolic blood pressure was 143 +/- 15 and 87 +/- 11 mmHg, respectively and the median albumin excretion rate was 27 ug/mg. Reduction in systolic and diastolic blood pressure was 16 mmHg/10 mmHg and the median UAER was 19.3 ug/mg after 24 weeks (P < 0.01, respectively). When we divided the subjects into three groups according to the UAER (normoalbuminuria, microalbuminuria and macroalbuminuria), significant changes were reported in the microalbuminuria and the macroalbuminuria groups. Thirty-eight (42%) patients with microalbuminuria improved to normoalbuminuria and twelve (41%) patients with macroalbuminuria improved to microalbuminuria. We found an association between the improvement of blood pressure and UAER (R = 0.165, P = 0.015). CONCLUSION: We concluded that valsartan reduces urinary albumin excretion and blood pressure in hypertensive type 2 diabetic patients.

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Effect of Valsartan on Blood Pressure and Urinary Albumin Excretion in Hypertensive Type 2 Diabetic Patients: An Open-Label, Multicenter Study.
    Korean Diabetes J. 2008;32(6):513-521.   Published online December 1, 2008
    Close
Related articles
Park SJ, Kim DJ, Kim HJ, Park SY, Seo JA, Kim NH, Choi SH, Lim S, Jang HC, Ko SH, Song KH, Ahn YB, Kim SK, Cho YW, Kang JG, Ihm SH, Park CY, Park SW, Shin DH, Kim YH, Lee KW. Effect of Valsartan on Blood Pressure and Urinary Albumin Excretion in Hypertensive Type 2 Diabetic Patients: An Open-Label, Multicenter Study.. Diabetes Metab J. 2008;32(6):513-521.
DOI: https://doi.org/10.4093/kdj.2008.32.6.513.

Diabetes Metab J : Diabetes & Metabolism Journal