Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.

Jun Hwa Hong; Ji Hye Lee; Jong Ho Shin; Dong Pil Kim; Bong Suk Ko; Byung Joon Kim; Hyun Jin Kim; Kang Seo Park

doi:10.4093/kdj.2008.32.6.529

Articles

Page Path: HOME > Diabetes Metab J > Volume 32(6); 2008 > Article

Case Report Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.: Jun Hwa Hong, Ji Hye Lee, Jong Ho Shin, Dong Pil Kim, Bong Suk Ko, Byung Joon Kim, Hyun Jin Kim, Kang Seo Park; Diabetes & Metabolism Journal 2008;32(6):529-531
DOI: https://doi.org/10.4093/kdj.2008.32.6.529
Published online: December 1, 2008

2,497 Views
32 Download
4 Crossref
0 Scopus

Department of Internal Medicine, Eulji University School of Medicine, Korea.

prev next

Full Article

Download PDF

Abstract

Allergic reaction to human insulin is uncommon. But they can cause mild to severe symptoms such as dyspnea, hypotensive shock, etc. Here we report the case of a patient with type 2 diabetes and insulin allergy successfully managed with desensitization. A 60-year-old man with insulin allergy was transferred. He had poorly controlled type 2 diabetes (fasting blood glucose 230 mg/dL). He developed itching sense and erythema at the injection sites of human insulin in a few minutes. And serum IgE level was elevated to 1618.0 IU/mL. The insulin was changed to other preparations, including short and long-acting insulin analogues, with similar responses. He was commenced on twice a day injection protocol in addition to his oral hypoglycemic agents, and achieved fair control (fasting blood glucose 100 mg/dL) on 24 units of Novomix Flex Pen per day, with little or no skin or systemic reaction. This is the case report of insulin allergy in type 2 diabetes being successfully managed by desensitization.

Keywords: Allergy;Desensitization;Insulin

Figure & Data

References

Citations

Citations to this article as recorded by

Allergic reaction to recombinant human insulin
Seong Jin Choi, Min Kwan Kwon, Moon Park, Soo Ya Bae, Hyun Ho Oh, Jong Ho Lee, Ji In Moon, Chan Sun Park, Jong Chul Won, Kyung Soo Ko, Byoung Doo Rhee, Jung Min Kim
Allergy, Asthma & Respiratory Disease.2015; 3(4): 302. CrossRef
Two Cases of Allergy to Insulin in Gestational Diabetes
Gi Jun Kim, Shin Bum Kim, Seong Il Jo, Jin Kyeong Shin, Hee Sun Kwon, Heekyung Jeong, Jang Won Son, Seong Su Lee, Sung Rae Kim, Byung Kee Kim, Soon Jib Yoo
Endocrinology and Metabolism.2015; 30(3): 402. CrossRef
Successful Management of Insulin Allergy and Autoimmune Polyendocrine Syndrome Type 4 with Desensitization Therapy and Glucocorticoid Treatment: A Case Report and Review of the Literature
Joselyn Rojas, Marjorie Villalobos, María Sofía Martínez, Mervin Chávez-Castillo, Wheeler Torres, José Carlos Mejías, Edgar Miquilena, Valmore Bermúdez
Case Reports in Immunology.2014; 2014: 1. CrossRef
Clinical applications of drug desensitization in the Asia-Pacific region
Bernard Yu-Hor Thong
Asia Pacific Allergy.2011; 1(1): 2. CrossRef

Cite

CITE: export Copy Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.

Korean Diabetes J. 2008;32(6):529-531. Published online December 1, 2008

DOI: https://doi.org/10.4093/kdj.2008.32.6.529

Related articles

About this article

Hong JH, Lee JH, Shin JH, Kim DP, Ko BS, Kim BJ, Kim HJ, Park KS. Maintenance of Insulin Therapy by Desensitization in Insulin Allergy Patient.. Diabetes Metab J. 2008;32(6):529-531.

DOI: https://doi.org/10.4093/kdj.2008.32.6.529.

Download citation ↓