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HOME > Diabetes Metab J > Volume 33(2); 2009 > Article
Review Insulin Resistance During Pregnancy.
Kyu Jeung Ahn
Diabetes & Metabolism Journal 2009;33(2):77-82
DOI: https://doi.org/10.4093/kdj.2009.33.2.77
Published online: April 1, 2009
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Endocrinology and Metabolism, Kyunghee East-West Neo Medical Center, Seoul, Korea.

Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental lactogen, TNF-alpha, resistin, leptin, and a decrease in adiponectin) as well as an increasing burden of fuel utilization by the conceptus. Metabolically, the first trimester is characterized by increased insulin sensitivity and lipogenesis. The second and third trimesters, in contrast, are characterized by insulin resistance and increased lipolysis.

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    Insulin Resistance During Pregnancy.
    Korean Diabetes J. 2009;33(2):77-82.   Published online April 1, 2009
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