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Diabetes Metab J : Diabetes & Metabolism Journal



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HOME > Diabetes Metab J > Volume 33(3); 2009 > Article
Review Diabetes and Osteoporosis.
Ki Won Oh
Diabetes & Metabolism Journal 2009;33(3):169-177
Published online: June 1, 2009
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Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of insulin and insulin-like growth factor I (IGF-I) system. Several clinical studies have reported adverse skeletal actions of peroxisome proliferator-activated receptor gamma (PPARgamma) agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but also by modulating adipokines that are known to affect bone remodeling.

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