The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes.

Seo,  Hyun Ae; Choi,  Yeon Kyung; Jeon,  Jae Han; Lee,  Jung Eun; Jeong,  Ji Yun; Moon,  Seong Su; Lee,  In Kyu; Kim,  Bo Wan; Kim,  Jung Guk

doi:2009.33.6.485

Diabetes Metab J > Volume 33(6); 2009 > Article

Original Article

Korean Diabetes Journal 2009;33(6):485-493.
DOI: https://doi.org/10.4093/kdj.2009.33.6.485 Published online December 1, 2009.

The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes.

Hyun Ae Seo, Yeon Kyung Choi, Jae Han Jeon, Jung Eun Lee, Ji Yun Jeong, Seong Su Moon, In Kyu Lee, Bo Wan Kim, Jung Guk Kim

Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jugkim@knu.ac.kr

Abstract

BACKGROUND
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. METHODS: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. RESULTS: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. CONCLUSION: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.

Key Words: Apolipoproteins, Atherosclerosis, Cardiovascular diseases, Lipids, Type 2 diabetes mellitus