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Original Article Leptin Concentration in Diabetin and Non-diabetin Subjects in the Community Population.
Kee Up Lee, Seong Kwan Hong, Sang Wook Kim, Young Il Kim, Yun Ey Chung, Moo Song Lee, Joong Yeoul Park, Jin Yup Kim
Diabetes & Metabolism Journal 1999;23(4):592-600
DOI: https://doi.org/
Published online: January 1, 2001
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1Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.

BACKGROUND
It has been suggested that adipose tissue releases leptin, a satiety factor, which circulates in blood and acts on the hypothalamus to suppress appetite. However, serum leptin concentration in obese human subjects is higher than that in lean subjects, suggesting leptin resistance. Although there have been several studies investigating serum leptin concentrations in Korean subjects, there has been no population-based study. This study was undertaken to investigate serum leptin concentration and associated factors in diabetic and non-diabetic subjects living in a rural area of Korea. METHOD: Among 898 subjects originally included in the Jung-up epidemiologic study, 119 men and 124 women with varying degrees of glucose tolerance were randomly selected. Serum leptin concentration was measured by radioimmunoassay. RESULTS: In agreement with previous studies, women had significantly higher serum leptin concentration than men. Serum leptin concentration in Korean men and women was apparently lower than in other populations, even after adjustment for BMI. Leptin concentration was not different among the three groups of glucose tolerance (normal glucose tolerance, impaired glucose tolerance and diabetes). Serum leptin concentration was positively correlated with serum true insulin, proinsulin and BMI in non-diabetic subjects. Serum leptin concentration was also significantly related with serum proinsulin/true insulin ratio in non-diabetic women. CONCLUSION: Serum leptin concentration in Korean subjects was lower than that reported in other populations. Serum leptin concentration was associated with BMI, serum true insulin and proinsulin levels in non-diabetic subjects, but not in diabetic ubjects.

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    Leptin Concentration in Diabetin and Non-diabetin Subjects in the Community Population.
    Korean Diabetes J. 1999;23(4):592-600.   Published online January 1, 2001
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Lee KU, Hong SK, Kim SW, Kim YI, Chung YE, Lee MS, Park JY, Kim JY. Leptin Concentration in Diabetin and Non-diabetin Subjects in the Community Population.. Diabetes Metab J. 1999;23(4):592-600.
DOI: https://doi.org/.

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