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Original Article Effect of Melatonin on the Diabetes Mellitus Induced by Streptozotocin in Rats.
Ri Ra Lee, You Hee Kim, Chun Sik Kwak, Mi Young Yeo, Kyo Cheol Mun
Diabetes & Metabolism Journal 2002;26(5):357-365
DOI: https://doi.org/
Published online: October 1, 2002
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Department of Biochemistry, Keimyung University School of Medicine, Taegu, Korea.

BACKGROUND
Oxygen free radicals are related to the pathogenesis and development of diabetes mellitus. The effect of melatonin, a known powerful antioxidant, was studied diabetes mellitus induced by streptozotocin in male Sprague-Dawley rats. METHODS: Diabetes was induced by the intraperitoneal injection of streptozotocin at 65 mg per kg of body weight. To know the effects of melatonin, two doses of 10 mg of melatonin per kg of body weight were administered intraperitoneally, the first simultaneously with the streptozotocin, and the second after a further 72 hours. The rats were then sacrificed at the 7th day after the first injection. The parameters including the levels of blood glucose, hemoglobin A1C, malondialdehyde and antioxidant enzymes were analysed to evaluate the diabetic state and the degree of lipid peroxidation by oxygen free radicals. RESULTS: The injection of streptozotocin caused significant increases in the levels of blood glucose, hemoglobin A1C and malondialdehyde. The injection of melatonin significantly reduced the levels of blood glucose and malondialdehyde. CONCLUSION: These results suggest melatonin may have a protective effect on the oxidative damage in the diabetes induced by streptozotocin.

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    Effect of Melatonin on the Diabetes Mellitus Induced by Streptozotocin in Rats.
    Korean Diabetes J. 2002;26(5):357-365.   Published online October 1, 2002
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Lee RR, Kim YH, Kwak CS, Yeo MY, Mun KC. Effect of Melatonin on the Diabetes Mellitus Induced by Streptozotocin in Rats.. Diabetes Metab J. 2002;26(5):357-365.
DOI: https://doi.org/.

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