Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
Chang-Myung Oh (Oh CM), Sangkyu Park (Park S), Hail Kim (Kim H)
Diabetes Metab J. 2016;40(2):89-98.   Published online 2016 Mar 27     DOI: https://doi.org/10.4093/dmj.2016.40.2.89
Citations to this article as recorded by Crossref logo
Targeting the Gut in Obesity: Signals from the Inner Surface
Natalia Petersen, Thomas U. Greiner, Lola Torz, Angie Bookout, Marina Kjærgaard Gerstenberg, Carlos M. Castorena, Rune Ehrenreich Kuhre
Metabolites.2022; 12(1): 39.     CrossRef
Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach
Hussein Kadhem Al-Hakeim, Hadi Hasan Hadi, Ghoufran Akeel Jawad, Michael Maes
Journal of Personalized Medicine.2022; 12(1): 23.     CrossRef
Tryptophan Metabolism in Atherosclerosis and Diabetes
Emina Sudar-Milovanovic, Zoran Gluvic, Milan Obradovic, Bozidarka Zaric, Esma R. Isenovic
Current Medicinal Chemistry.2022; 29(1): 99.     CrossRef
The Temporal Profile of Circulating miRNAs during Gestation in Overweight and Obese Women with or without Gestational Diabetes Mellitus
Anja Elaine Sørensen, Mireille N. M. van Poppel, Gernot Desoye, David Simmons, Peter Damm, Dorte Møller Jensen, Louise Torp Dalgaard
Biomedicines.2022; 10(2): 482.     CrossRef
Comparative effectiveness of Hypericum perforatum, acupuncture, and lifestyle modification in the management of obesity: A randomized clinical trial
Monirsadat Sahebkar-Khorasani, Mohammad Safarian, Lida Jarahi, Mahdi Yousefi, Roshanak Salari, Mojtaba Meshkat, Mohammad Hossein Ayati, Hamidreza Bahrami-Taghanaki, Raheleh Kargozar, Hoda Azizi
European Journal of Integrative Medicine.2022; 52: 102119.     CrossRef
Research Progresses for 5-Hydroxytryptamine in Lipid Metabolism
钰婷 吴
Bioprocess.2022; 12(01): 1.     CrossRef
Fast and Sensitive Quantification of AccQ-Tag Derivatized Amino Acids and Biogenic Amines by UHPLC-UV Analysis from Complex Biological Samples
Andrea Guba, Orsolya Bába, József Tőzsér, Éva Csősz, Gergő Kalló
Metabolites.2022; 12(3): 272.     CrossRef
Chronic Treatment With Psilocybin Decreases Changes in Body Weight in a Rodent Model of Obesity
Joyce Huang, Michelle Pham, William J. Panenka, William G. Honer, Alasdair M. Barr
Frontiers in Psychiatry.2022;[Epub]     CrossRef
Antidepressants for depressed patients with type 2 diabetes mellitus: A systematic review and network meta-analysis of short-term randomized controlled trials
Manit Srisurapanont, Sirijit Suttajit, Natapong Kosachunhanun, Surinporn Likhitsathian, Chawisa Suradom, Benchalak Maneeton
Neuroscience & Biobehavioral Reviews.2022; 139: 104731.     CrossRef
Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease
Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
European Journal of Medicinal Chemistry.2022; 239: 114517.     CrossRef
The serotonergic system dysfunction in diabetes mellitus
Yan Cai, Xiaolong Li, Hongli Zhou, Jiyin Zhou
Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
Journal of Medicinal Chemistry.2021; 64(2): 1037.     CrossRef
Serotonin level as a potent diabetes biomarker based on electrochemical sensing: a new approach in a zebra fish model
Kamyar Khoshnevisan, Hadi Baharifar, Farzad Torabi, Mahsa Sadeghi Afjeh, Hassan Maleki, Elham Honarvarfard, Hassan Mohammadi, Sayed Mahmoud Sajjadi-Jazi, Sadegh Mahmoudi-Kohan, Farnoush Faridbod, Bagher Larijani, Farshid Saadat, Reza Faridi Majidi, Mohamm
Analytical and Bioanalytical Chemistry.2021; 413(6): 1615.     CrossRef
Serotonin, food intake, and obesity
Katy A. Galen, Kasper W. Horst, Mireille J. Serlie
Obesity Reviews.2021;[Epub]     CrossRef
Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice
Luciano N. de Sousa, Débora S. Paraguassú Sant'ana, Rildo G. Siqueira dos Santos, Anita Eugênia A. dos Santos Ribeiro, Camila F. da Costa, Ana Paula de Oliveira, Jackson Roberto G. da Silva Almeida, Davi M. Jucá, Moisés Tolentino, Armênio A. dos Santos, R
Current Research in Pharmacology and Drug Discovery.2021; 2: 100018.     CrossRef
An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease
Xiaolan Li, Zhi‐Hong Zhang, Hossain M. Zabed, Junhua Yun, Guoyan Zhang, Xianghui Qi
Molecular Nutrition & Food Research.2021; 65(5): 2000461.     CrossRef
A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
Suhyeon Park, Yumin Kim, Jibeom Lee, Jeong Yun Lee, Hail Kim, Sunjae Lee, Chang-Myung Oh
International Journal of Molecular Sciences.2021; 22(5): 2452.     CrossRef
Loss of Znt8 function in diabetes mellitus: risk or benefit?
Carla P. Barragán-Álvarez, Eduardo Padilla-Camberos, Nestor F. Díaz, Agustín Cota-Coronado, Claudia Hernández-Jiménez, Carlos C. Bravo-Reyna, Nestor E. Díaz-Martínez
Molecular and Cellular Biochemistry.2021; 476(7): 2703.     CrossRef
Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark
Pukar Khanal, B. M. Patil
3 Biotech.2021;[Epub]     CrossRef
A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes
Chun-Feng Huang, Ann Chen, Siao-Yun Lin, Mei-Ling Cheng, Ming-Shi Shiao, Tso-Yen Mao
Saudi Journal of Biological Sciences.2021; 28(8): 4762.     CrossRef
Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
Maja Kesić, Petra Baković, Ranko Stojković, Jasminka Štefulj, Lipa Čičin-Šain
International Journal of Molecular Sciences.2021; 22(10): 5400.     CrossRef
The effects of 5-hydroxytryptophan on carrageenan-induced mouse paw oedemas
Gokçen TELLI, Inci KAZKAYASI, Serdar UMA
Revista de Nutrição.2021;[Epub]     CrossRef
Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
Helen Irving, Ilona Turek, Christine Kettle, Nor Yaakob
International Journal of Molecular Sciences.2021; 22(21): 11910.     CrossRef
Serotonergic Regulation of Hepatic Energy Metabolism
Jiwon Park, Wooju Jeong, Chahyeon Yun, Hail Kim, Chang-Myung Oh
Endocrinology and Metabolism.2021; 36(6): 1151.     CrossRef
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease
Minhee Kim, Inseon Hwang, Haushabhau S. Pagire, Suvarna H. Pagire, Wonsuk Choi, Won Gun Choi, Jihyeon Yoon, Won Mi Lee, Jin Sook Song, Eun Kyung Yoo, Seung Mi Lee, Mi-jin Kim, Myung Ae Bae, Dooseop Kim, Heejong Lee, Eun-Young Lee, Jae-Han Jeon, In-Kyu Lee
Journal of Medicinal Chemistry.2020; 63(8): 4171.     CrossRef
Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis
Maja Kesić, Petra Baković, Marina Horvatiček, Bastien Lucien Jean Proust, Jasminka Štefulj, Lipa Čičin-Šain
Frontiers in Neuroscience.2020;[Epub]     CrossRef
Appetite and weight control by Hypericum perforatum and acupuncture added to lifestyle modification: Study protocol for a randomized clinical trial
Monirsadat Sahebkar-Khorasani, Mohammad Safarian, Lida Jarahi, Mahdi Yousefi, Roshanak Salari, Hoda Azizi
Advances in Integrative Medicine.2020; 7(2): 101.     CrossRef
Update on the genetic and epigenetic etiology of gestational diabetes mellitus: a review
Tajudeen O. Yahaya, Titilola Salisu, Yusuf B. Abdulrahman, Abdulrazak K. Umar
Egyptian Journal of Medical Human Genetics.2020;[Epub]     CrossRef
Paraben Exposure Related To Purine Metabolism and Other Pathways Revealed by Mass Spectrometry-Based Metabolomics
Hongzhi Zhao, Yuanyuan Zheng, Lin Zhu, Li Xiang, Yanqiu Zhou, Jiufeng Li, Jing Fang, Shunqing Xu, Wei Xia, Zongwei Cai
Environmental Science & Technology.2020; 54(6): 3447.     CrossRef
An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model
Tugba Gurpinar Çavuşoğlu, Ertan Darıverenli, Kamil Vural, Nuran Ekerbicer, Cevval Ulman, Ercüment Ölmez, Nazan Uysal
Turkish Journal of Biochemistry.2020; 45(4): 397.     CrossRef
Pomegranate Metabolites Impact Tryptophan Metabolism in Humans and Mice
Jieping Yang, Yuanqiang Guo, Rupo Lee, Susanne M Henning, Jing Wang, Yajing Pan, Tianyu Qing, Mark Hsu, Alex Nguyen, Siddarth Prabha, Rashi Ojha, Gary W Small, David Heber, Zhaoping Li
Current Developments in Nutrition.2020;[Epub]     CrossRef
Network pharmacology-based assessment to elucidate the molecular mechanism of anti-diabetic action of Tinospora cordifolia
Pukar Khanal, B. M. Patil, Bijendra K. Mandar, Yadu Nandan Dey, Taaza Duyu
Clinical Phytoscience.2019;[Epub]     CrossRef
The distribution of serotonergic nerve on the hippocampus of the fruit bats (Rousettus amplexicaudatus)
Vivin Wirawati, Nourrisma D. A. Widiati, Geraldus Gunawan, Golda R. Saragih, Puspa Hening, Hevi Wihadmadyatami
Veterinary World.2019; 12(9): 1460.     CrossRef
How important is tryptophan in human health?
Joanna Kałużna-Czaplińska, Paulina Gątarek, Salvatore Chirumbolo, Max Stanley Chartrand, Geir Bjørklund
Critical Reviews in Food Science and Nutrition.2019; 59(1): 72.     CrossRef
Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats
Tetiana Halenova, Igor Zlatskiy, Anton Syroeshkin, Tatiana Maximova, Tatiana Pleteneva
Molecules.2019; 25(1): 23.     CrossRef
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions
Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen, Hanne D. Hansen
EJNMMI Research.2019;[Epub]     CrossRef
Biological activities of water‐soluble polysaccharides from Opuntia humifusa stem in high‐fat‐diet‐fed mice
Eun‐In Yang, Chang‐Hyun Lee, Denis Nchang Che, Seon‐Il Jang, Young‐Soo Kim
Journal of Food Biochemistry.2019; 43(4): e12806.     CrossRef
Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment
Ian Pepper, Aaron Vinik, Frank Lattanzio, William McPheat, Anca Dobrian
Frontiers in Endocrinology.2019;[Epub]     CrossRef
The regulation of insulin secretion via phosphoinositide-specific phospholipase Cβ signaling
Hyeon-Jeong Hwang, Hyun-Jun Jang, Lucio Cocco, Pann-Ghill Suh
Advances in Biological Regulation.2019; 71: 10.     CrossRef
Clostridium ramosum regulates enterochromaffin cell development and serotonin release
Ana D. Mandić, Anni Woting, Tina Jaenicke, Anika Sander, Wiebke Sabrowski, Ulrike Rolle-Kampcyk, Martin von Bergen, Michael Blaut
Scientific Reports.2019;[Epub]     CrossRef
Estrogen – serotonin interaction and its implication on insulin resistance
Zulvikar Syambani Ulhaq
Alexandria Journal of Medicine.2019; 55(1): 76.     CrossRef
Serotonin prevents differentiation into brown adipocytes and induces transdifferentiation into white adipocytes
S Rozenblit-Susan, N Chapnik, O Froy
International Journal of Obesity.2018; 42(4): 704.     CrossRef
Combined brain Fe, Cu, Zn and neurometabolite analysis – a new methodology for unraveling the efficacy of transcranial direct current stimulation (tDCS) in appetite control
Agata Ziomber, Artur Dawid Surowka, Lucyna Antkiewicz-Michaluk, Irena Romanska, Pawel Wrobel, Magdalena Szczerbowska-Boruchowska
Metallomics.2018; 10(3): 397.     CrossRef
The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation
Jeffrey S. Kruk, Sandra Bermeo, Kristen K. Skarratt, Stephen J. Fuller, Gustavo Duque
Journal of Bone Metabolism.2018; 25(1): 43.     CrossRef
Acute anti-obesity effects of intracerebroventricular 11β-HSD1 inhibitor administration in diet-induced obese mice
M. Seo, S. A. Islam, S.-S. Moon
Journal of Neuroendocrinology.2018; 30(3): e12580.     CrossRef
Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications
Jeffery A. Goldstein, Lisa A. Bastarache, Joshua C. Denny, Dan M. Roden, Jill M. Pulley, David M. Aronoff
Pharmacological Research.2018; 130: 44.     CrossRef
Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat
Xiaowen Han, Mengjun Min, Juan Wang, Zejun Bao, Hongbin Fan, Xinyu Li, Temitope Isaac Adelusi, Xueyan Zhou, Xiaoxing Yin
Journal of Neuroscience Research.2018; 96(1): 138.     CrossRef
A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion- and stress-related eating, food cravings and appetite
A. M. Chao, T. A. Wadden, R. L. Pearl, N. Alamuddin, S. M. Leonard, Z. M. Bakizada, E. Pinkasavage, K. A. Gruber, O. A. Walsh, R. I. Berkowitz, N. Alfaris, J. S. Tronieri
Clinical Obesity.2018; 8(6): 383.     CrossRef
Lorcaserin and metabolic disease: weight‐loss dependent and independent effects
H. Bays, C. Perdomo, E. Nikonova, R. Knoth, M. Malhotra
Obesity Science & Practice.2018; 4(6): 499.     CrossRef
Rol del sistema serotoninérgico en la diabetes mellitus y sus dianas farmacológicas
Victor Orozco, Camilo Caicedo
Revista Médica Sanitas.2018; 21(3): 125.     CrossRef
Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats
O. O. Kalmukova, A. V. Yurchenko, V. M. Kyryk, V. M. Nepomnyaschy, O. M. Savchuk, M. E. Dzerzhynsky
Neurophysiology.2018; 50(6): 398.     CrossRef
Role of central and peripheral serotonin in obesity: what to expect in the near pharmacotherapy future?
Mina T Kelleni
Advances in Obesity, Weight Management & Control.2018;[Epub]     CrossRef
Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation
Samantha R. Weaver, Allan S. Prichard, Noah L. Maerz, Austin P. Prichard, Elizabeth L. Endres, Lorenzo E. Hernández-Castellano, Matthew S. Akins, Rupert M. Bruckmaier, Laura L. Hernandez, Juan J. Loor
PLOS ONE.2017; 12(9): e0184939.     CrossRef
Biology of obesity and weight regain
Mary Madeline Rogge, Bibha Gautam
Journal of the American Association of Nurse Practitioners.2017; 29(S1): S15.     CrossRef
5-HT 2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
Minal Jaggar, Noelia Weisstaub, Jay A. Gingrich, Vidita A. Vaidya
Neurobiology of Stress.2017; 7: 89.     CrossRef
Serotonergic Control of Metabolic Homeostasis
Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu
Frontiers in Cellular Neuroscience.2017;[Epub]     CrossRef
Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan
Journal of Diabetes Research.2017; 2017: 1.     CrossRef
Bivalent role of intra-platelet serotonin in liver regeneration and tumor recurrence in humans
Robin Padickakudy, David Pereyra, Florian Offensperger, Philipp Jonas, Lukas Oehlberger, Christian Schwarz, Stefanie Haegele, Alice Assinger, Christine Brostjan, Thomas Gruenberger, Patrick Starlinger
Journal of Hepatology.2017; 67(6): 1243.     CrossRef
Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review
T. Montanari, N. Pošćić, M. Colitti
Obesity Reviews.2017; 18(5): 495.     CrossRef
Cross-Talk Between Insulin Signaling and G Protein–Coupled Receptors
Qin Fu, Qian Shi, Toni M. West, Yang K. Xiang
Journal of Cardiovascular Pharmacology.2017; 70(2): 74.     CrossRef
P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions
Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B. Komissarov, Franco Venanzi, Sergey I. Kolesnikov, Albert A. Sufianov, Michael Y. Sherman, Vladimir L. Gabai, Alexander M. Shneider
Oncotarget.2017; 8(34): 56030.     CrossRef
Regulation of Systemic Energy Homeostasis by Peripheral Serotonin
Jun Namkung, Chang-Myung Oh, Sangkyu Park, Hail Kim
Journal of mucopolysaccharidosis and rare disease.2016; 2(2): 43.     CrossRef
Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo
Cell Reports.2016; 17(12): 3281.     CrossRef