Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
150 "insulin resistance"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Cardiovascular Risk/Epidemiology
Article image
Artificial Light at Night and Type 2 Diabetes Mellitus
Jong-Ha Baek, Yong Zhu, Chandra L. Jackson, Yong-Moon Mark Park
Diabetes Metab J. 2024;48(5):847-863.   Published online September 12, 2024
DOI: https://doi.org/10.4093/dmj.2024.0237
  • 2,367 View
  • 202 Download
AbstractAbstract PDFPubReader   ePub   
The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor of natural circadian rhythms, potentially leading to a rise in unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon has been associated with an increased risk of type 2 diabetes mellitus (T2DM), which is a pressing global public health concern. However, to date, reviews summarizing associations between ALAN and T2DM have primarily focused on the limited characteristics of exposure (e.g., intensity) to ALAN. This literature review extends beyond prior reviews by consolidating recent studies from 2000 to 2024 regarding associations between both indoor and outdoor ALAN exposure and the incidence or prevalence of T2DM. We also described potential biological mechanisms through which ALAN modulates glucose metabolism. Furthermore, we outlined knowledge gaps and investigated how various ALAN characteristics beyond only light intensity (including light type, timing, duration, wavelength, and individual sensitivity) influence T2DM risk. Recognizing the detrimental impact of ALAN on sleep health and the behavioral correlates of physical activity and dietary patterns, we additionally summarized studies investigating the potential mediating role of each component in the relationship between ALAN and glucose metabolism. Lastly, we proposed implications of chronotherapies and chrononutrition for diabetes management in the context of ALAN exposure.
Original Article
Metabolic Risk/Epidemiology
Article image
A Prospective 1-Year Follow-up of Glycemic Status and C-Peptide Levels of COVID-19 Survivors with Dysglycemia in Acute COVID-19 Infection
David Tak Wai Lui, Chi Ho Lee, Ying Wong, Carol Ho Yi Fong, Kimberly Hang Tsoi, Yu Cho Woo, Kathryn Choon Beng Tan
Diabetes Metab J. 2024;48(4):763-770.   Published online March 11, 2024
DOI: https://doi.org/10.4093/dmj.2023.0175
  • 1,622 View
  • 143 Download
AbstractAbstract PDFPubReader   ePub   
Background
We evaluated changes in glycemic status, over 1 year, of coronavirus disease 2019 (COVID-19) survivors with dysglycemia in acute COVID-19.
Methods
COVID-19 survivors who had dysglycemia (defined by glycosylated hemoglobin [HbA1c] 5.7% to 6.4% or random glucose ≥10.0 mmol/L) in acute COVID-19 were recruited from a major COVID-19 treatment center from September to October 2020. Matched non-COVID controls were recruited from community. The 75-g oral glucose tolerance test (OGTT) were performed at baseline (6 weeks after acute COVID-19) and 1 year after acute COVID-19, with HbA1c, insulin and C-peptide measurements. Progression in glycemic status was defined by progression from normoglycemia to prediabetes/diabetes, or prediabetes to diabetes.
Results
Fifty-two COVID-19 survivors were recruited. Compared with non-COVID controls, they had higher C-peptide (P< 0.001) and trend towards higher homeostasis model assessment of insulin resistance (P=0.065). Forty-three COVID-19 survivors attended 1-year reassessment. HbA1c increased from 5.5%±0.3% to 5.7%±0.2% (P<0.001), with increases in glucose on OGTT at fasting (P=0.089), 30-minute (P=0.126), 1-hour (P=0.014), and 2-hour (P=0.165). At baseline, 19 subjects had normoglycemia, 23 had prediabetes, and one had diabetes. Over 1 year, 10 subjects (23.8%; of 42 non-diabetes subjects at baseline) had progression in glycemic status. C-peptide levels remained unchanged (P=0.835). Matsuda index decreased (P=0.007) and there was a trend of body mass index increase from 24.4±2.7 kg/m2 to 25.6±5.2 (P=0.083). Subjects with progression in glycemic status had more severe COVID-19 illness than non-progressors (P=0.030). Reassessment was not performed in the control group.
Conclusion
Subjects who had dysglycemia in acute COVID-19 were characterized by insulin resistance. Over 1 year, a quarter had progression in glycemic status, especially those with more severe COVID-19. Importantly, there was no significant deterioration in insulin secretory capacity.
Sulwon Lecture 2023
Metabolic Risk/Epidemiology
Article image
Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
Inha Jung, Dae-Jeong Koo, Won-Young Lee
Diabetes Metab J. 2024;48(3):327-339.   Published online February 2, 2024
DOI: https://doi.org/10.4093/dmj.2023.0350
  • 3,932 View
  • 454 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFPubReader   ePub   
It has been generally accepted that insulin resistance (IR) and reduced insulin secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, the persistence of systemic inflammation caused by obesity and the associated threat of lipotoxicity increase the risk of T2DM. In particular, the main cause of IR is obesity and subjects with T2DM have a higher body mass index (BMI) than normal subjects according to recent studies. The prevalence of T2DM with IR has increased with increasing BMI during the past three decades. According to recent studies, homeostatic model assessment of IR was increased compared to that of the 1990s. Rising prevalence of obesity in Korea have contributed to the development of IR, non-alcoholic fatty liver disease and T2DM and cutting this vicious cycle is important. My colleagues and I have investigated this pathogenic mechanism on this theme through clinical and experimental studies over 20 years and herein, I would like to summarize some of our studies with deep gratitude for receiving the prestigious 2023 Sulwon Award.

Citations

Citations to this article as recorded by  
  • Strategy for treating MAFLD: Electroacupuncture alleviates hepatic steatosis and fibrosis by enhancing AMPK mediated glycolipid metabolism and autophagy in T2DM rats
    Haoru Duan, Shanshan Song, Rui Li, Suqin Hu, Shuting Zhuang, Shaoyang liu, Xiaolu Li, Wei Gao
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
Original Articles
Drug/Regimen
Article image
Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
Ji Hye Heo, Kyung Ah Han, Jun Hwa Hong, Hyun-Ae Seo, Eun-Gyoung Hong, Jae Myung Yu, Hye Seung Jung, Bong-Soo Cha
Diabetes Metab J. 2024;48(5):937-948.   Published online February 2, 2024
DOI: https://doi.org/10.4093/dmj.2023.0314
  • 5,374 View
  • 410 Download
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study assessed the efficacy and safety of triple therapy with pioglitazone 15 mg add-on versus placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and dapagliflozin.
Methods
In this multicenter, double-blind, randomized, phase 3 study, patients with T2DM with an inadequate response to treatment with metformin (≥1,000 mg/day) plus dapagliflozin (10 mg/day) were randomized to receive additional pioglitazone 15 mg/day (n=125) or placebo (n=125) for 24 weeks. The primary endpoint was the change in glycosylated hemoglobin (HbA1c) levels from baseline to week 24 (ClinicalTrials.gov identifier: NCT05101135).
Results
At week 24, the adjusted mean change from baseline in HbA1c level compared with placebo was significantly greater with pioglitazone treatment (–0.47%; 95% confidence interval, –0.61 to –0.33; P<0.0001). A greater proportion of patients achieved HbA1c <7% or <6.5% at week 24 with pioglitazone compared to placebo as add-on to 10 mg dapagliflozin and metformin (56.8% vs. 28% for HbA1c <7%, and 23.2% vs. 9.6% for HbA1c <6.5%; P<0.0001 for all). The addition of pioglitazone also significantly improved triglyceride, highdensity lipoprotein cholesterol levels, and homeostatic model assessment of insulin resistance levels, while placebo did not. The incidence of treatment-emergent adverse events was similar between the groups, and the incidence of fluid retention-related side effects by pioglitazone was low (1.5%).
Conclusion
Triple therapy with the addition of 15 mg/day of pioglitazone to dapagliflozin plus metformin was well tolerated and produced significant improvements in HbA1c in patients with T2DM inadequately controlled with dapagliflozin plus metformin.

Citations

Citations to this article as recorded by  
  • Ideal Combination of Oral Hypoglycemic Agents for Patients with Type 2 Diabetes Mellitus
    Hye Soon Kim
    Diabetes & Metabolism Journal.2024; 48(5): 882.     CrossRef
Metabolic Risk/Epidemiology
Article image
Harnessing Metabolic Indices as a Predictive Tool for Cardiovascular Disease in a Korean Population without Known Major Cardiovascular Event
Hyun-Jin Kim, Byung Sik Kim, Yonggu Lee, Sang Bong Ahn, Dong Wook Kim, Jeong-Hun Shin
Diabetes Metab J. 2024;48(3):449-462.   Published online February 1, 2024
DOI: https://doi.org/10.4093/dmj.2023.0197
  • 2,258 View
  • 223 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study evaluated the usefulness of indices for metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and insulin resistance (IR), as predictive tools for cardiovascular disease in middle-aged Korean adults.
Methods
The prospective data obtained from the Ansan-Ansung cohort database, excluding patients with major adverse cardiac and cerebrovascular events (MACCE). The primary outcome was the incidence of MACCE during the follow-up period.
Results
A total of 9,337 patients were included in the analysis, of whom 1,130 (12.1%) experienced MACCE during a median follow-up period of 15.5 years. The metabolic syndrome severity Z-score, metabolic syndrome severity score, hepatic steatosis index, and NAFLD liver fat score were found to significantly predict MACCE at values above the cut-off point and in the second and third tertiles. Among these indices, the hazard ratios of the metabolic syndrome severity score and metabolic syndrome severity Z-score were the highest after adjusting for confounding factors. The area under the receiver operating characteristic curve (AUC) of the 10-year atherosclerotic cardiovascular disease (ASCVD) score for predicting MACCE was 0.716, and the metabolic syndrome severity Z-score had an AUC of 0.619.
Conclusion
The metabolic syndrome severity score is a highly reliable indicator and was closely associated with the 10-year ASCVD risk score in predicting MACCE in the general population. Given the specific characteristics and limitations of metabolic syndrome severity scores as well as the indices of NAFLD and IR, a more practical scoring system that considers these factors is essential to achieve greater accuracy in forecasting cardiovascular outcomes.

Citations

Citations to this article as recorded by  
  • Association between mixed exposure to per- and polyfluoroalkyl substances and metabolic syndrome in Korean adults: Data from the Korean National environmental health survey cycle 4
    Seung Min Chung, Kyun Hoo Kim, Jun Sung Moon, Kyu Chang Won
    International Journal of Hygiene and Environmental Health.2024; 261: 114427.     CrossRef
  • Estimated pulse wave velocity as a forefront indicator of developing metabolic syndrome in Korean adults
    Hyun-Jin Kim, Byung Sik Kim, Dong Wook Kim, Jeong-Hun Shin
    The Korean Journal of Internal Medicine.2024; 39(4): 612.     CrossRef
Pathophysiology
Article image
Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity
Xiaorui Yu, Jiawang Tao, Yuhang Wu, Yan Chen, Penghui Li, Fan Yang, Miaoxiu Tang, Abdul Sammad, Yu Tao, Yingying Xu, Yin-Xiong Li
Diabetes Metab J. 2024;48(4):802-815.   Published online February 1, 2024
DOI: https://doi.org/10.4093/dmj.2023.0124
  • 2,010 View
  • 122 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Insulin resistance (IR) is the key pathological basis of many metabolic disorders. Lack of asialoglycoprotein receptor 1 (ASGR1) decreased the serum lipid levels and reduced the risk of coronary artery disease. However, whether ASGR1 also participates in the regulatory network of insulin sensitivity and glucose metabolism remains unknown.
Methods
The constructed ASGR1 knockout mice and ASGR1-/- HepG2 cell lines were used to establish the animal model of metabolic syndrome and the IR cell model by high-fat diet (HFD) or drug induction, respectively. Then we evaluated the glucose metabolism and insulin signaling in vivo and in vitro.
Results
ASGR1 deficiency ameliorated systemic IR in mice fed with HFD, evidenced by improved insulin intolerance, serum insulin, and homeostasis model assessment of IR index, mainly contributed from increased insulin signaling in the liver, but not in muscle or adipose tissues. Meanwhile, the insulin signal transduction was significantly enhanced in ASGR1-/- HepG2 cells. By transcriptome analyses and comparison, those differentially expressed genes between ASGR1 null and wild type were enriched in the insulin signal pathway, particularly in phosphoinositide 3-kinase-AKT signaling. Notably, ASGR1 deficiency significantly reduced hepatic gluconeogenesis and glycogenolysis.
Conclusion
The ASGR1 deficiency was consequentially linked with improved hepatic insulin sensitivity under metabolic stress, hepatic IR was the core factor of systemic IR, and overcoming hepatic IR significantly relieved the systemic IR. It suggests that ASGR1 is a potential intervention target for improving systemic IR in metabolic disorders.
Review
Pathophysiology
Article image
Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
Yajie Fan, Zhipeng Yan, Tingting Li, Aolin Li, Xinbiao Fan, Zhongwen Qi, Junping Zhang
Diabetes Metab J. 2024;48(1):19-36.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2023.0110
  • 5,507 View
  • 261 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   ePub   
Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.

Citations

Citations to this article as recorded by  
  • Association between METS-IR and heart failure: a cross-sectional study
    Xiaozhou Su, Chunli Zhao, Xianwei Zhang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Insulin–Heart Axis: Bridging Physiology to Insulin Resistance
    Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Celestino Sardu, Luca Rinaldi, Vincenzo Russo, Marcellino Monda, Raffaele Marfella, Ferdinando Carlo Sasso
    International Journal of Molecular Sciences.2024; 25(15): 8369.     CrossRef
  • The web of intrigue: unraveling the role of NETosis within the gut-microbiome-immune-heart axis in acute myocardial infarction and heart failure
    Tai Yasuda, Kate Deans, Aditi Shankar, Robert Chilton
    Cardiovascular Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance
    Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Rocío Llamas-Ramos, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ruth Martí-Lluch, María Cortés Rodríguez, Inés Llamas-Ramos, Manuel A. Gómez-Marcos
    Nutrients.2024; 16(18): 3106.     CrossRef
  • Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
    Qin Ru, Yusheng Li, Lin Chen, Yuxiang Wu, Junxia Min, Fudi Wang
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
Original Articles
Drug/Regimen
Article image
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
Ji Hye Han, Kyong Hye Joung, Jun Choul Lee, Ok Soon Kim, Sorim Choung, Ji Min Kim, Yea Eun Kang, Hyon-Seung Yi, Ju Hee Lee, Bon Jeong Ku, Hyun Jin Kim
Diabetes Metab J. 2024;48(1):112-121.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2022.0402
  • 4,603 View
  • 393 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Type 2 diabetes mellitus (T2DM) induces endothelial dysfunction and inflammation, which are the main factors for atherosclerosis and cardiovascular disease. The present study aimed to compare the effects of rosuvastatin monotherapy and rosuvastatin/ezetimibe combination therapy on lipid profile, insulin sensitivity, and vascular inflammatory response in patients with T2DM.
Methods
A total of 101 patients with T2DM and dyslipidemia were randomized to either rosuvastatin monotherapy (5 mg/day, n=47) or rosuvastatin/ezetimibe combination therapy (5 mg/10 mg/day, n=45) and treated for 12 weeks. Serum lipids, glucose, insulin, soluble intercellular adhesion molecule-1 (sICAM-1), and peroxiredoxin 4 (PRDX4) levels were determined before and after 12 weeks of treatment.
Results
The reduction in low density lipoprotein cholesterol (LDL-C) by more than 50% from baseline after treatment was more in the combination therapy group. The serum sICAM-1 levels increased significantly in both groups, but there was no difference between the two groups. The significant changes in homeostasis model assessment of insulin resistance (HOMA-IR) and PRDX4 were confirmed only in the subgroup in which LDL-C was reduced by 50% or more in the combination therapy group. However, after adjusting for diabetes mellitus duration and hypertension, the changes in HOMA-IR and PRDX4 were not significant between the two groups.
Conclusion
Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.

Citations

Citations to this article as recorded by  
  • Combining Ezetimibe and Rosuvastatin: Impacts on Insulin Sensitivity and Vascular Inflammation in Patients with Type 2 Diabetes Mellitus
    Eun Roh
    Diabetes & Metabolism Journal.2024; 48(1): 55.     CrossRef
  • Does Rosuvastatin/Ezetimibe Combination Therapy Offer Potential Benefits for Glucose Metabolism beyond Lipid-Lowering Efficacy in T2DM?
    Il Rae Park, Jun Sung Moon
    Diabetes & Metabolism Journal.2024; 48(3): 387.     CrossRef
  • A Comparison of Rosuvastatin Monotherapy and Rosuvastatin Plus Ezetimibe Combination Therapy in Patients With Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
    Samuel K Dadzie, Godfrey Tabowei, Mandeep Kaur, Saeed Ahmed, Aayushi Thakur, Khaldoun Khreis, Monika Bai, Adil Amin
    Cureus.2024;[Epub]     CrossRef
  • The Pleiotropic Effects of Lipid-Modifying Interventions: Exploring Traditional and Emerging Hypolipidemic Therapies
    Dimitris Kounatidis, Nikolaos Tentolouris, Natalia G. Vallianou, Iordanis Mourouzis, Irene Karampela, Theodora Stratigou, Eleni Rebelos, Marina Kouveletsou, Vasileios Stamatopoulos, Eleni Tsaroucha, Maria Dalamaga
    Metabolites.2024; 14(7): 388.     CrossRef
Basic Research
Article image
A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc
Vladimir Vinokur, Eduard Berenshtein, Mordechai Chevion, Dror Chevion
Diabetes Metab J. 2024;48(1):59-71.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2022.0292
Retraction in: Diabetes Metab J 2024;48(2):325
  • 2,792 View
  • 178 Download
  • 2 Web of Science
  • 1 Crossref
Basic Research
Article image
Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis
Xuwen Tang, Qingxin Qin, Wenjing Xu, Xuezhen Zhang
Diabetes Metab J. 2023;47(2):267-286.   Published online January 19, 2023
DOI: https://doi.org/10.4093/dmj.2021.0216
  • 4,127 View
  • 212 Download
  • 6 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated gene 1 (TUG1) influences insulin resistance (IR) in a high-fat diet (HFD)-induced mouse model of GDM.
Methods
We initially developed a mouse model of HFD-induced GDM, from which islet tissues were collected for RNA and protein extraction. Interactions among lncRNA TUG1/microRNA (miR)-328-3p/sterol regulatory element binding protein 2 (SREBP-2) were assessed by dual-luciferase reporter assay. Fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA pancreatic β-cell function (HOMA-β), insulin sensitivity index for oral glucose tolerance tests (ISOGTT) and insulinogenic index (IGI) levels in mouse serum were measured through conducting gain- and loss-of-function experiments.
Results
Abundant expression of miR-328 and deficient expression of lncRNA TUG1 and SREBP-2 were characterized in the islet tissues of mice with HFD-induced GDM. LncRNA TUG1 competitively bound to miR-328-3p, which specifically targeted SREBP-2. Either depletion of miR-328-3p or restoration of lncRNA TUG1 and SREBP-2 reduced the FBG, FINS, HOMA-β, and HOMA-IR levels while increasing ISOGTT and IGI levels, promoting the expression of the extracellular signal-regulated kinase (ERK) signaling pathway-related genes, and inhibiting apoptosis of islet cells in GDM mice. Upregulation miR-328-3p reversed the alleviative effects of SREBP-2 and lncRNA TUG1 on IR.
Conclusion
Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR-328-3p and promoting the SREBP-2-mediated ERK signaling pathway inactivation.

Citations

Citations to this article as recorded by  
  • Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
    Mohammed Ageeli Hakami
    Saudi Journal of Biological Sciences.2024; 31(5): 103976.     CrossRef
  • Effect of Tinospora cordifolia on gestational diabetes mellitus and its complications
    Ritu Rani, Havagiray Chitme, Avinash Kumar Sharma
    Women & Health.2023; 63(5): 359.     CrossRef
  • Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model
    Ritu Rani, Avinash Kumar Sharma, Havagiray R Chitme
    Clinical Medicine Insights: Endocrinology and Diabetes.2023;[Epub]     CrossRef
  • The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes
    Dong Gao, Liping Ren, Yu-Duo Hao, Nalini Schaduangrat, Xiao-Wei Liu, Shi-Shi Yuan, Yu-He Yang, Yan Wang, Watshara Shoombuatong, Hui Ding
    Briefings in Bioinformatics.2023;[Epub]     CrossRef
  • lncRNA TUG1 as Potential Novel Biomarker for Prognosis of Cardiovascular Diseases
    Habib Haybar, Narjes Sadat Sadati, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
    Epigenomics.2023; 15(23): 1273.     CrossRef
Short Communication
Others
Article image
Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective
Insa Laspe, Juris J. Meier, Michael A. Nauck
Diabetes Metab J. 2023;47(1):140-146.   Published online March 22, 2022
DOI: https://doi.org/10.4093/dmj.2021.0322
  • 65,535 View
  • 201 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
In clinical practice, the distinction between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) can be challenging, leaving patients with “ambiguous” diabetes type. Insulin-treated patients (n=115) previously diagnosed with T2DM had to be re-classified based on clinical phenotype and laboratory results, and were operationally defined as having an ambiguous diabetes type. They were compared against patients with definite T1DM and T2DM regarding 12 clinical and laboratory features typically different between diabetes types. Characteristics of patients with ambiguous diabetes type, representing approximately 6% of all patients with T1DM or T2DM seen at our specialized clinic, fell in between those of patients with definite T1DM and T2DM, both regarding individual features and with respect to a novel classification based on multi-variable regression analysis (P<0.0001). In conclusion, a substantial proportion of diabetes patients in a tertiary care centre presented with an “ambiguous” diabetes type. Their clinical characteristics fall in between those of definite T1DM or T2DM patients.
Original Articles
Metabolic Risk/Epidemiology
Article image
Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study
Shanhu Qiu, Xue Cai, Bo Xie, Yang Yuan, Zilin Sun, Tongzhi Wu
Diabetes Metab J. 2022;46(3):476-485.   Published online March 7, 2022
DOI: https://doi.org/10.4093/dmj.2021.0074
  • 5,931 View
  • 223 Download
  • 11 Web of Science
  • 11 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Creatinine-to-cystatin C ratio is recently suggested to be a surrogate marker for sarcopenia. However, little is known about its association with diabetes. This study aimed to fill in this gap based on a large-scale prospective cohort.
Methods
A population-based representative sample of 5,055 participants aged ≥45 years from the China Health and Retirement Longitudinal Study was enrolled between 2011 and 2012 and followed at least once during the subsequent surveys at 2013, 2015, or 2018. Creatinine-to-cystatin C ratio was calculated and normalized by body weight. Incident diabetes was ascertained by plasma glucose, glycosylated hemoglobin, self-reported history, or use of anti-diabetic drugs. Logistic regression analysis and mediation analysis were employed.
Results
During follow-up, 634 participants developed diabetes. The risk of diabetes was gradually and significantly decreased with increased normalized creatinine–cystatin C ratio. The multivariable-adjusted odds ratio for diabetes was 0.91 (95% confidence interval, 0.83 to 0.99) per 1 standard deviation higher of normalized creatinine-to-cystatin C ratio, and this relationship remained significant after controlling for muscle strength. The risk reduction in diabetes was significantly larger in participants with normal-weight and high normalized creatinine-to-cystatin C ratio compared with those with overweight/obesity and high normalized creatinine-to-cystatin C ratio (Pinteraction=0.01). Insulin resistance and inflammation appeared to be key mediators accounting for the observed relationship between normalized creatinine-to-cystatin C ratio and risk of diabetes, with their mediating effect being 93.1% and 22.0%, respectively.
Conclusion
High normalized creatinine-to-cystatin C ratio is associated with reduced risk of diabetes in middle-aged and older adults.

Citations

Citations to this article as recorded by  
  • Muscle Quality in Relation to Prediabetes Phenotypes: A Population-Based Study With Mediation Analysis
    Shanhu Qiu, Xue Cai, Xiaoying Zhou, Jinshui Xu, Zilin Sun, Haijian Guo, Tongzhi Wu
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1151.     CrossRef
  • Sex‐specific associations between skeletal muscle mass and incident diabetes: A population‐based cohort study
    Dan Liu, Nan Li, Yiling Zhou, Miye Wang, Peige Song, Changzheng Yuan, Qingyang Shi, Hui Chen, Kaixin Zhou, Huan Wang, Tao Li, Xiong‐Fei Pan, Haoming Tian, Sheyu Li
    Diabetes, Obesity and Metabolism.2024; 26(3): 820.     CrossRef
  • Diabetes Mellitus Should Be Considered While Analysing Sarcopenia-Related Biomarkers
    Justyna Rentflejsz, Zyta Beata Wojszel
    Journal of Clinical Medicine.2024; 13(4): 1107.     CrossRef
  • Associations of muscle mass and strength with new-onset diabetes among middle-aged and older adults: evidence from the China health and retirement longitudinal study (CHARLS)
    Yun-Yun He, Mei-Ling Jin, Xiang-Yang Fang, Xiao-Juan Wang
    Acta Diabetologica.2024; 61(7): 869.     CrossRef
  • Lower serum creatinine to cystatin C ratio associated with increased incidence of frailty in community-dwelling elderly men but not in elderly women
    Shixian Zhou, Peixia Wang, Linlin Sun, Xinxiu Zhao, Caixia Gong, Yichen Yang, Wen Ren, Yunmei Yang, Qin Zhang, JingJin Jiang
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • Creatinine-to-cystatin C ratio and frailty in older adults: a longitudinal cohort study
    Quhong Song, Taiping Lin, Rui Liang, Yanli Zhao, Ning Ge, Jirong Yue
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Sex difference in the association between creatinine-to-cystatin C ratio and metabolic syndrome among Chinese adults
    Jo-Hsuan Chen, Jau-Yuan Chen, Yi-Chuan Chen, Wen-Cheng Li
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Sex and Age Influence the Relationship Between Serum Creatinine/Cystatin C and Carotid Plaque in Patients With Type 2 Diabetes Mellitus
    Dan Yang, Kexin Li, Qiujuan Zhang, Tian Yu, Ling Liu, You Wang, Shuyuan Kang, Shumiao Song, Baofeng Xu, Rui Liu
    Angiology.2024;[Epub]     CrossRef
  • The serum creatinine to cystatin C to waist circumference ratios predicts risk for type 2 diabetes: A Chinese cohort study
    Yinfei Chen, Weiheng Wen, Zhiliang Mai, Ming Wang, Hong Chen, Jia Sun
    Journal of Diabetes.2023; 15(10): 808.     CrossRef
  • Associations of sarcopenia with peak expiratory flow among community-dwelling elderly population: based on the China Health and Retirement Longitudinal Study (CHARLS)
    Yun-Yun He, Mei-Ling Jin, Jing Chang, Xiao-Juan Wang
    European Geriatric Medicine.2023; 15(1): 95.     CrossRef
  • Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study
    Eyun Song, Soon Young Hwang, Min Jeong Park, Ahreum Jang, Kyeong Jin Kim, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
    Metabolism.2023; 148: 155678.     CrossRef
Metabolic Risk/Epidemiology
Iron Overload and the Risk of Diabetes in the General Population: Results of the Chinese Health and Nutrition Survey Cohort Study
He Gao, Jinying Yang, Wenfei Pan, Min Yang
Diabetes Metab J. 2022;46(2):307-318.   Published online March 7, 2022
DOI: https://doi.org/10.4093/dmj.2020.0287
  • 6,311 View
  • 233 Download
  • 17 Web of Science
  • 17 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Recent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among iron overload (IO), insulin resistance (IR), and diabetes in Chinese adults, and to explore the sex difference.
Methods
Men and women (age >19 years) who participated in the Chinese Health and Nutrition Survey and did not have diabetes at baseline were followed between 2009 and 2015 (n=5,779). Over a mean of 6 years, 75 participants were diagnosed with incident diabetes. Logistic regression was used to assess the risk factors associated with IO. Cox proportional hazard regression was used to estimate the risk of incident diabetes and to determine whether the risk differed among subgroups. Causal mediation analysis (CMA) was used to explore the mechanism linking IO and diabetes.
Results
According to sex-stratified multivariable-adjusted Cox proportional hazards regression, IO increased the risk of incident diabetes. Women with IO had a higher risk of diabetes than men. Subgroup analysis with respect to age showed that the association between IO and diabetes was stronger in older women and younger men (P<0.001). CMA showed that liver injury (alanine transaminase) and lipid metabolism abnormalities (triglyceride, apolipoprotein B) contributed to the association between IO and diabetes.
Conclusion
IO is associated with diabetes and this association is sex-specific. IO may indirectly induce IR via liver injury and lipid metabolism abnormalities, resulting in diabetes.

Citations

Citations to this article as recorded by  
  • Micronutrient Patterns and Low Intake of Vitamin A, Vitamin D, Folate, Magnesium, and Potassium Among Prediabetes and Type 2 Diabetes Patients
    Oana C Iatcu, Andrei Lobiuc, Mihai Covasa
    Cureus.2024;[Epub]     CrossRef
  • The levels, single and multiple health risk assessment of 23 metals in enteral nutrition formulas
    Burhan Basaran, Hulya Turk
    Food and Chemical Toxicology.2024; 192: 114914.     CrossRef
  • Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis
    Sana Mohammadi, Sadegh Ghaderi, Fatemeh Sayehmiri, Mobina Fathi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Iron Overload Induces Hepatic Ferroptosis and Insulin Resistance by Inhibiting the Jak2/stat3/slc7a11 Signaling Pathway
    Manqiu Mo, Ling Pan, Ling Deng, Min Liang, Ning Xia, Yuzhen Liang
    Cell Biochemistry and Biophysics.2024; 82(3): 2079.     CrossRef
  • Diatom Chaetoceros Sp. as an Efficient Biological Antidote in Iron Toxicity: In‐Vitro and In‐Vivo Experiments
    Zeinab Janahmadi, Shadi Talebi, Fatemeh Farjadian, Safieh Momeni
    ChemistrySelect.2024;[Epub]     CrossRef
  • Endogenous iron biomineralization in the mouse spleen of metabolic diseases
    Ruowen Guo, Lei Zhang, Dongsheng Song, Biao Yu, Chao Song, Hanxiao Chen, Wenjing Xie, Chuanlin Feng, Guofeng Cheng, Kejun Hu, Jialiang Jiang, Zhe Qu, Haifeng Du, Xin Zhang
    Fundamental Research.2024;[Epub]     CrossRef
  • Plasma Ferritin Concentrations in the General Population: A Cross-Sectional Analysis of Anthropometric, Metabolic, and Dietary Correlates
    Cara Övermöhle, Sabina Waniek, Gerald Rimbach, Katharina Susanne Weber, Wolfgang Lieb
    The Journal of Nutrition.2023; 153(5): 1524.     CrossRef
  • Association of Body Iron Metabolism with Type 2 Diabetes Mellitus in Chinese Women of Childbearing Age: Results from the China Adult Chronic Disease and Nutrition Surveillance (2015)
    Jie Feng, Xiaoyun Shan, Lijuan Wang, Jiaxi Lu, Yang Cao, Lichen Yang
    Nutrients.2023; 15(8): 1935.     CrossRef
  • Iron overload induces islet β cell ferroptosis by activating ASK1/P-P38/CHOP signaling pathway
    Ling Deng, Man-Qiu Mo, Jinling Zhong, Zhengming Li, Guoqiao Li, Yuzhen Liang
    PeerJ.2023; 11: e15206.     CrossRef
  • The role of ferroptosis in metabolic diseases
    Ling Xie, Bin Fang, Chun Zhang
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(6): 119480.     CrossRef
  • Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes
    Xuekui Liu, Xiu Hong, Shiqiang Jiang, Rui Li, Qian Lv, Jie Wang, Xiuli Wang, Manqing Yang, Houfa Geng, Yang Li
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Association between serum iron and liver transaminases based on a large adult women population
    Andong He, Zhuoping Zhou, Lili Huang, Ka Cheuk Yip, Jing Chen, Ruiling Yan, Ruiman Li
    Journal of Health, Population and Nutrition.2023;[Epub]     CrossRef
  • Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population
    Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
    PeerJ.2023; 11: e16267.     CrossRef
  • The Role of Iron Overload in Diabetic Cognitive Impairment: A Review
    Ji-Ren An, Qing-Feng Wang, Gui-Yan Sun, Jia-Nan Su, Jun-Tong Liu, Chi Zhang, Li Wang, Dan Teng, Yu-Feng Yang, Yan Shi
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3235.     CrossRef
  • The Association Between METS-IR and Serum Ferritin Level in United States Female: A Cross-Sectional Study Based on NHANES
    Han Hao, Yan Chen, Ji Xiaojuan, Zhang Siqi, Chu Hailiang, Sun Xiaoxing, Wang Qikai, Xing Mingquan, Feng Jiangzhou, Ge Hongfeng
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus
    Zhongjing Wang, Shu Fang, Sheng Ding, Qin Tan, Xuyan Zhang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 2259.     CrossRef
  • Iron deficiency in cardiac surgical patients
    L Hof, O Old, A.U. Steinbicker, P Meybohm, S Choorapoikayil, K Zacharowski
    Acta Anaesthesiologica Belgica.2022; 73(4): 235.     CrossRef
Reviews
Pathophysiology
Article image
Insulin Resistance: From Mechanisms to Therapeutic Strategies
Shin-Hae Lee, Shi-Young Park, Cheol Soo Choi
Diabetes Metab J. 2022;46(1):15-37.   Published online December 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0280
  • 47,621 View
  • 3,715 Download
  • 286 Web of Science
  • 317 Crossref
AbstractAbstract PDFPubReader   ePub   
Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance.

Citations

Citations to this article as recorded by  
  • Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source
    Gandhar Pradhan, Yogesh A. Kulkarni
    Current Diabetes Reviews.2025;[Epub]     CrossRef
  • Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes
    Debashree Mazumdar, Santosh Singh
    Indian Journal of Clinical Biochemistry.2024; 39(1): 3.     CrossRef
  • Underlying mechanisms and molecular targets of genistein in the management of type 2 diabetes mellitus and related complications
    Tao Jiang, Yuhe Dong, Wanying Zhu, Tong Wu, Linyan Chen, Yuantong Cao, Xi Yu, Ye Peng, Ling Wang, Ying Xiao, Tian Zhong
    Critical Reviews in Food Science and Nutrition.2024; 64(31): 11543.     CrossRef
  • Validation of a physiological type 2 diabetes model in human periodontal ligament stem cells
    Dongqing Ai, Yuanyuan Yin, Xuyun Xia, Sihan Yang, Yu Sun, Jie Zhou, Han Qin, Xiaohui Xu, Jinlin Song
    Oral Diseases.2024; 30(5): 3363.     CrossRef
  • Materials and structure of polysaccharide-based delivery carriers for oral insulin: A review
    Xinran Wang, Hongnan Sun, Taihua Mu
    Carbohydrate Polymers.2024; 323: 121364.     CrossRef
  • β-Thalassemia and Diabetes Mellitus: Current State and Future Directions
    Jalal Taneera, Eglal Mahgoub, Reem Qannita, Ayah Alalami, Ola Al Shehadat, Mona Youssef, Ayah Dib, Alaa Al Hajji, Amani Al Hajji, Fatheya Al-Khaja, Hany Dewedar, Mawieh Hamad
    Hormone and Metabolic Research.2024; 56(04): 272.     CrossRef
  • Mulberry leaf multi-components exert hypoglycemic effects through regulation of the PI-3K/Akt insulin signaling pathway in type 2 diabetic rats
    Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
    Journal of Ethnopharmacology.2024; 319: 117307.     CrossRef
  • Thyroid cancer and insulin resistance
    Gabriela Brenta, Fernando Di Fermo
    Reviews in Endocrine and Metabolic Disorders.2024; 25(1): 19.     CrossRef
  • Comparative profiling of gut microbiota and metabolome in diet-induced obese and insulin-resistant C57BL/6J mice
    Hobby Aggarwal, Jyoti Gautam, Deepika Kumari, Sonu Kumar Gupta, Sneh Bajpai, Kartikey Chaturvedi, Yashwant Kumar, Madhu Dikshit
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2024; 1871(2): 119643.     CrossRef
  • CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation
    Patricia O. Benedet, Nooshin S. Safikhan, Maria J. Pereira, Bryan M. Lum, José Diego Botezelli, Cheng-Hsiang Kuo, Hua-Lin Wu, Barbara P. Craddock, W. Todd Miller, Jan W. Eriksson, Jessica T.Y. Yue, Edward M. Conway
    eBioMedicine.2024; 99: 104906.     CrossRef
  • The Antiobesity Effects and Potential Mechanisms of Theaflavins
    Yi Fang, Jun Wang, Yu Cao, Wenrui Liu, Lianxiang Duan, Jing Hu, Jinghua Peng
    Journal of Medicinal Food.2024; 27(1): 1.     CrossRef
  • The role of zinc finger proteins in the fate determination of mesenchymal stem cells during osteogenic and adipogenic differentiation
    Bolun Li, Shibo Liu, Ze He, En Luo, Hanghang Liu
    The International Journal of Biochemistry & Cell Biology.2024; 167: 106507.     CrossRef
  • Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action
    Ying Wei, Jiaxin Sun, Liya Su, Tunhai Xu
    Pharmacognosy Magazine.2024; 20(2): 646.     CrossRef
  • Hyperglycemia affects axial signs in patients with Parkinson’s disease through mechanisms of insulin resistance or non-insulin resistance
    Ruidan Wang, Zhaohui Jin, Qiaoxia Zhen, Lin Qi, Cui Liu, Ping Wang, Yonghong Liu, Jinping Fang, Yanjun Liu, Yuan Su, Yixuan Wang, Detao Meng, Hongjiao Yan, Yi Zhen, Zhenzhen Li, Boyan Fang
    Neurological Sciences.2024; 45(5): 2011.     CrossRef
  • Insulin resistance: Risk factors, diagnostic approaches and mathematical models for clinical practice, epidemiological studies, and beyond
    Janusz Krzymien, Piotr Ladyzynski
    Biocybernetics and Biomedical Engineering.2024; 44(1): 55.     CrossRef
  • Effects of silybin supplementation on growth performance, serum indexes and liver transcriptome of Peking ducks
    Ziyue Zhang, Bozhi Shi, Xueze Lv, Yingchao Dong, Lei Li, Zhaofei Xia
    Frontiers in Veterinary Science.2024;[Epub]     CrossRef
  • Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults
    Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle V. Nunez, Desiree M. Sigala, Andrew A. Bremer, Chad L. Cox, Nancy L. Keim, Jean-Marc Schwarz, Giovanni Pacini, Andrea Tura, Peter J. Havel, Kimber L. Stanhope
    Nutrients.2024; 16(1): 151.     CrossRef
  • Association Between Insulin Resistance Markers and Poor Prognosis in Patients With Acute Ischemic Stroke After Intravenous Thrombolysis
    Haimei Liu, Denglu Liu, Peng Zuo
    The Neurologist.2024; 29(4): 218.     CrossRef
  • Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus
    Ewa Szczepanska-Sadowska
    International Journal of Molecular Sciences.2024; 25(2): 1310.     CrossRef
  • High-Density Lipoprotein Is Located Alongside Insulin in the Islets of Langerhans of Normal and Rodent Models of Diabetes
    Sahar Mohsin, Haba Elabadlah, Mariam K. Alotaiba, Suhail AlAmry, Shamma J. Almehairbi, Maha M. K. Harara, Aisha M. H. Almuhsin, Saeed Tariq, Frank Christopher Howarth, Ernest A. Adeghate
    Nutrients.2024; 16(2): 313.     CrossRef
  • Sweet triterpenoid glycoside from Cyclocarya paliurus ameliorates obesity-induced insulin resistance through inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway
    Jie Li, Junyu He, Haibo He, Xiao Wang, Shuran Zhang, Yumin He, Jihong Zhang, Chengfu Yuan, HongWu Wang, Daoxiang Xu, Chaowang Pan, Huifan Yu, Kun Zou
    Current Research in Food Science.2024; 8: 100677.     CrossRef
  • Effect of supplementation with probiotics or synbiotics on cardiovascular risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomized clinical trials
    TingRui Chen, Jing Wang, ZeKun Liu, Fei Gao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Diabetes mellitus progression in β-thalassaemia major patients: The impact of iron overload
    Eglal Omer Mahgoub, Reem Qannita, Ayah Alalami, Ola Al Shehadat, Rabah Al Mahmoud, Ayah Dib, Alaa Al Hajji, Amani Al Hajji, Fatheya Al Khaja, Hany Dewedar, Mawieh Hamad, Jalal Taneera
    Advances in Biomedical and Health Sciences.2024; 3(1): 5.     CrossRef
  • Dietary Tomato Pectin Attenuates Hepatic Insulin Resistance and Inflammation in High-Fat-Diet Mice by Regulating the PI3K/AKT Pathway
    Jing Sun, Kongyan Wu, Pan Wang, Yubin Wang, Dan Wang, Wenting Zhao, Yuanyuan Zhao, Chunhong Zhang, Xiaoyan Zhao
    Foods.2024; 13(3): 444.     CrossRef
  • Atractylodes macrocephala Koidz. and Cuscuta chinensis Lam. extract relieves insulin resistance via PI3K/Akt signalling in diabetic Drosophila
    Yinghong Li, Ye Xu, Biwei Zhang, Zhigang Wang, Leilei Ma, Longyu Sun, Xiuping Wang, Yimin Lin, Ji-an Li, Chenxi Wu
    Journal of Traditional and Complementary Medicine.2024; 14(4): 424.     CrossRef
  • Ketogenic diet ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle by alleviating endoplasmic reticulum stress
    Qin Ma, Lincheng Jiang, Yuehua You, Hongbing Ni, Li Ma, Xiaojing Lin, Zhuyun Wang, Weiyan Yan, Xiaoqiu Xiao, Xinyu Li, Jibin Li
    Biochemical and Biophysical Research Communications.2024; 702: 149559.     CrossRef
  • Brain insulin resistance and Alzheimer’s disease: a systematic review
    Luis Jesuino de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Letícia Góes de Carvalho Lourenço, Gabriela Correia Matos de Oliveira
    Dementia & Neuropsychologia.2024;[Epub]     CrossRef
  • Poorly controlled glycemia and worse beta cell function associate with higher resting and total energy expenditure in adults with obesity and type 2 diabetes: A doubly labeled water study
    Kate Lillegard, John A. Del Castillo, Heidi J. Silver
    Clinical Nutrition.2024; 43(3): 729.     CrossRef
  • Gut microbiota in insulin resistance: a bibliometric analysis
    Weiwei Tian, Li Liu, Ruirui Wang, Yunyun Quan, Bihua Tang, Dongmei Yu, Lei Zhang, Hua Hua, Junning Zhao
    Journal of Diabetes & Metabolic Disorders.2024; 23(1): 173.     CrossRef
  • Association of the triglyceride glucose index with all-cause and cardiovascular mortality in a general population of Iranian adults
    Ghazaal Alavi Tabatabaei, Noushin Mohammadifard, Hamed Rafiee, Fatemeh Nouri, Asieh Maghami mehr, Jamshid Najafian, Masoumeh Sadeghi, Maryam Boshtam, Hamidreza Roohafza, Fahimeh Haghighatdoost, Marzieh Taheri, Nizal Sarrafzadegan
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Changes in Cells Associated with Insulin Resistance
    Leszek Szablewski
    International Journal of Molecular Sciences.2024; 25(4): 2397.     CrossRef
  • Assessment of insulin resistance using the HOMA index: a comparative approach between premenopausal and postmenopausal women
    Ericka Jazmín Tubón Luisa, Carlos Fernando Yauli Flores
    Salud, Ciencia y Tecnología.2024; 4: 729.     CrossRef
  • Insulin Resistance: The Increased Risk of Cancers
    Leszek Szablewski
    Current Oncology.2024; 31(2): 998.     CrossRef
  • Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
    Xuan-Yu Hao, Kai Zhang, Xing-Yong Huang, Fei Yang, Si-Yu Sun
    World Journal of Gastroenterology.2024; 30(7): 636.     CrossRef
  • Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance
    Thomas Ebert, Stefan D. Anker, Luis M. Ruilope, Paola Fioretto, Vivian Fonseca, Guillermo E. Umpierrez, Andreas L. Birkenfeld, Robert Lawatscheck, Charlie Scott, Katja Rohwedder, Peter Rossing
    Diabetes Care.2024; 47(3): 362.     CrossRef
  • Influence of Obesity and Insulin Resistance on the Reproductive Outcome of Iraqi Women Undergoing Intracytoplasmic Sperm Injection
    Sundus Ali Dawood, Hayder Ali Lafta Mossa, Mufeeda Ali Jwad
    Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2024; 6(1): 179.     CrossRef
  • Metabolic memory: mechanisms and diseases
    Hao Dong, Yuezhang Sun, Lulingxiao Nie, Aimin Cui, Pengfei Zhao, Wai Keung Leung, Qi Wang
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
  • Effect of preoperative oral carbohydrates on insulin resistance in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
    Xiaohan Wang, Jingwen Zhuang, Jianxin Cheng, Zeyang Wang, Jingyi Sheng, Shanshan Guo, Rui Wang, Zhiping Wang
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5
    Lu Ding, Yang Sun, Yan Liang, Jie Zhang, Zhendong Fu, Caiyue Ren, Pengfei Li, Wen Liu, Rong Xiao, Hao Wang, Zhaoying Zhang, Xuetian Yue, Chunyang Li, Zhuanchang Wu, Yuemin Feng, Xiaohong Liang, Chunhong Ma, Lifen Gao
    Advanced Science.2024;[Epub]     CrossRef
  • Metabolic syndrome awareness in the general Korean population: results from a nationwide survey
    Hyun-Jin Kim, Mi-Seung Shin, Kyung-Hee Kim, Mi-Hyang Jung, Dong-Hyuk Cho, Ju-Hee Lee, Kwang Kon Koh
    The Korean Journal of Internal Medicine.2024; 39(2): 272.     CrossRef
  • Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet
    Lidya H. Gebreyesus, Sora Choi, Prince Neequaye, Mattia Mahmoud, Mia Mahmoud, Malvin Ofosu-Boateng, Elizabeth Twum, Daniel O. Nnamani, Lijin Wang, Nour Yadak, Sujoy Ghosh, Frank J. Gonzalez, Maxwell A. Gyamfi
    Biomedicine & Pharmacotherapy.2024; 173: 116341.     CrossRef
  • TyG-GGT is a Reliable Non-Invasive Predictor of Advanced Liver Fibrosis in Overweight or Obese Individuals
    Lei Jin, Jing Gu, Zhe Zhang, Cheng-Fei Du, Fei-Qi Xu, Xiao-Kun Huang, Zhen-Yu Gao, Ying Li, Li-Li Yu, Xin Zhang, Guo-Qing Ru, Jun-Wei Liu, Lei Liang, Xiao-Dong Sun, Zun-Qiang Xiao
    Obesity Surgery.2024; 34(4): 1333.     CrossRef
  • Excess homocysteine inhibits pancreatic β-cell secretory function by repressing Zbtb20 expression
    Tianqi Ding, Bo Wen, Jian Chen, Wenbin Chu, Rong Fan, Xuewei Chen
    Molecular and Cellular Endocrinology.2024; 586: 112195.     CrossRef
  • Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase
    Yuliya Tishova, Svetlana Kalinchenko, George Mskhalaya, Geoffrey Hackett, Mark Livingston, Carola König, Richard Strange, Michael Zitzmann, Amar Mann, Amro Maarouf, Sudarshan Ramachandran
    Diabetes, Obesity and Metabolism.2024; 26(6): 2147.     CrossRef
  • Preoperative contributing factors and the remission of diabetes after metabolic surgery: the mediating role of preoperative triglyceride
    Lijuan Niu, Liqian Mu, Runda Wu, Shan Tong, Zhongqi Mao, Yi Yang, Jun Yin
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2024;[Epub]     CrossRef
  • Mechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila
    Yinghong Li, Fanwu Wu, Jianbo Zhang, Ye Xu, Hong Chang, Yueyue Yu, Chunhua Jiang, Xiujuan Gao, Huijuan Liu, Zhen Chen, Chenxi Wu, Ji-An Li
    Drug Design, Development and Therapy.2024; Volume 18: 747.     CrossRef
  • Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
    Mohammed Ageeli Hakami
    Saudi Journal of Biological Sciences.2024; 31(5): 103976.     CrossRef
  • Sleep quality of patients with diabetes mellitus: association with anxiety trait and state
    Lidiane Bernardes Faria Vilela, Larissa Cristina dos Santos Camargos, Guilherme Rocha Rodrigues, Adelzí Auto Alves Júnior, Renato Canevari Dutra da Silva, Elton Brás Camargo Júnior
    Revista Gaúcha de Enfermagem.2024;[Epub]     CrossRef
  • Qualidade do sono de pacientes com diabetes mellitus: associação com ansiedade traço e estado
    Lidiane Bernardes Faria Vilela, Larissa Cristina dos Santos Camargos, Guilherme Rocha Rodrigues, Adelzí Auto Alves Júnior, Renato Canevari Dutra da Silva, Elton Brás Camargo Júnior
    Revista Gaúcha de Enfermagem.2024;[Epub]     CrossRef
  • Association of the triglyceride-glucose index with severity of coronary stenosis and in-hospital mortality in patients with acute ST elevation myocardial infarction after percutaneous coronary intervention: a multicentre retrospective analysis cohort stud
    Xin Lu, Xin Lin, Yingying Cai, Xiaoxiao Zhang, Haoyu Meng, Weiwei Chen, Peng Yu, Xiaohu Chen
    BMJ Open.2024; 14(3): e081727.     CrossRef
  • Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
    Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song
    Brain Sciences.2024; 14(3): 284.     CrossRef
  • Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders
    Maha Alser, Khaled Naja, Mohamed A. Elrayess
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Regulation of lipid metabolism by E3 ubiquitin ligases in lipid-associated metabolic diseases
    Yuanming Zou, Ying Zhang, Mohan Li, Kexin Cao, Chunyu Song, Zhaobo Zhang, Kexin Cai, Danxi Geng, Shuxian Chen, Yanjiao Wu, Naijin Zhang, Guozhe Sun, Jing Wang, Yixiao Zhang, Yingxian Sun
    International Journal of Biological Macromolecules.2024; 265: 130961.     CrossRef
  • METS-IR and all-cause mortality in Korean over 60 years old: Korean genome and epidemiology study-health examinees (KoGES-HEXA) cohorts
    Ha Eun Ryu, Dong Hyuk Jung, Seok-Jae Heo, Byoungjin Park, Yong Jae Lee
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Effects of vitamin family members on insulin resistance and diabetes complications
    Hong-Jin Chen, Min Wang, Ding-Min Zou, Gui-You Liang, Si-Yuan Yang
    World Journal of Diabetes.2024; 15(3): 568.     CrossRef
  • Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms
    Qian Yu, Xiang Zuo, Huijuan Bai, Shuhui Zhang, Jialu Luan, Qili Zhao, Xin Zhao, Xizeng Feng
    European Journal of Pharmacology.2024; 971: 176529.     CrossRef
  • The genetic causal relationship between type 2 diabetes, glycemic traits and venous thromboembolism, deep vein thrombosis, pulmonary embolism: a two-sample Mendelian randomization study
    Mingyi Yang, Xianjie Wan, Yani Su, Ke Xu, Pengfei Wen, Binfei Zhang, Lin Liu, Zhi Yang, Peng Xu
    Thrombosis Journal.2024;[Epub]     CrossRef
  • Transgenerational inheritance of insulin resistance in offspring of white rice-fed female fruit flies
    Kehinde Ahmad Adeshina, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Mustapha Umar Imam
    Scientific African.2024; 24: e02208.     CrossRef
  • PPARβ/δ as a promising molecular drug target for liver diseases: A focused review
    Xin Meng, Lin Wang, Yan-Chao Du, Dong Cheng, Tao Zeng
    Clinics and Research in Hepatology and Gastroenterology.2024; 48(6): 102343.     CrossRef
  • EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation—targeting GPR120/PPARγ pathway
    Xian Yang, Xudong Li, Manjiang Hu, Jie Huang, Siyan Yu, Huanting Zeng, Limei Mao
    The Journal of Nutritional Biochemistry.2024; 130: 109648.     CrossRef
  • The impact of diabetes mellitus on the development of psychiatric and neurological disorders
    Olivia Kelly, Jillian Sullivan, Natalie Carris, Samantha Geci, Athena Martinez, Varvara Liashenko, James Colvin, Emily Misko, Gary Vanderlaan, He Liu, Prasad S. Dalvi
    Brain Disorders.2024; 14: 100135.     CrossRef
  • Oligonucleotide therapies for nonalcoholic steatohepatitis
    Sixu Li, Feng Xiong, Songbo Zhang, Jinghua Liu, Guangping Gao, Jun Xie, Yi Wang
    Molecular Therapy - Nucleic Acids.2024; 35(2): 102184.     CrossRef
  • The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology
    Samo Ribarič
    International Journal of Molecular Sciences.2024; 25(8): 4358.     CrossRef
  • Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride–glucose index with arterial stiffness risk
    Wenkai Zhang, Weifeng Huo, Huifang Hu, Tianze Li, Lijun Yuan, Jinli Zhang, Yifei Feng, Yuying Wu, Xueru Fu, Yamin Ke, Mengmeng Wang, Longkang Wang, Yaobing Chen, Yajuan Gao, Xi Li, Liang Sun, Jinyuan Pang, Zeqiang Zheng, Fulan Hu, Ming Zhang, Yu Liu, Dong
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Unraveling PCOS: Exploring its causes and diagnostic challenges
    Mohd Altaf Dar, Mudasir Maqbool, Zulfkar Qadrie, Irfat Ara, Afshana Qadir
    Open Health.2024;[Epub]     CrossRef
  • Association Between Triglyceride-Glucose Index and Diabetic Retinopathy: A Meta-Analysis
    Lanchu Yu, Bingqing Li
    Hormone and Metabolic Research.2024;[Epub]     CrossRef
  • Serum Klotho and insulin resistance: Insights from a cross-sectional analysis
    Laisha Yan, Xiaoyan Hu, Shanshan Wu, Shunying Zhao
    Medicine.2024; 103(17): e37971.     CrossRef
  • Research Progress of Correlation between Triglyceride Glucose Index and Kidney Disease
    伊琳 黄
    Advances in Clinical Medicine.2024; 14(04): 2137.     CrossRef
  • Oxygen-Dependent Aspects of Asprosin Action
    V. V. Zinchuk, J. S. O. Al-Jebur
    Journal of Evolutionary Biochemistry and Physiology.2024; 60(2): 818.     CrossRef
  • Differential Modulation by Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) of Mesenteric Fat and Macrophages and T Cells in Adipose Tissue of Obese fa/fa Zucker Rats
    Lena Hong, Peter Zahradka, Carla G. Taylor
    Nutrients.2024; 16(9): 1311.     CrossRef
  • Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case–control study
    Yang Yang, Shengru Liang, Jiangdong Liu, Minghao Man, Yue Si, Dengfeng Jia, Jianwei Li, Xiaoxi Tian, Lihong Li
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice
    Jiani Lu, Zhengshan Tang, Miaomiao Xu, Jianqiang Lu, Fengmei Wang, Xin Ni, Changnan Wang, Bo Yu
    Redox Report.2024;[Epub]     CrossRef
  • Significance of vitamin D responsiveness on the etiology of vitamin D-related diseases
    Ulla M. Järvelin, Juho M. Järvelin
    Steroids.2024; 207: 109437.     CrossRef
  • Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES
    Chao Wang, Mengdi Shi, Chunsheng Lin, Jingyi Wang, Liangzhen Xie, Yan Li
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults
    Armando Ramírez-Cruz, María Judith Rios-Lugo, Jacqueline Soto-Sánchez, Cuauhtémoc Arturo Juárez-Pérez, Alejandro Cabello-López, Carmina Jiménez-Ramírez, Consuelo Chang-Rueda, Miguel Cruz, Héctor Hernández-Mendoza, Miguel Vazquez-Moreno
    Metabolites.2024; 14(5): 282.     CrossRef
  • Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease
    Chaoyue Zhang, Yunke Shi, Changzhi Liu, Shivon Mirza Sudesh, Zhao Hu, Pengyang Li, Qi Liu, Yiming Ma, Ao Shi, Hongyan Cai
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study
    Hong Li, Liu Li, Qiu-Qing Huang, Si-Yao Yang, Jun-Ju Zou, Fan Xiao, Qin Xiang, Xiu Liu, Rong Yu
    World Journal of Diabetes.2024; 15(5): 1021.     CrossRef
  • Association of serum total IgE and allergen-specific IgE with insulin resistance in adolescents: an analysis of the NHANES database
    Yaping Liu, Xiaoxia Wang, Yong Liu
    BMC Pediatrics.2024;[Epub]     CrossRef
  • A national study exploring the association between triglyceride-glucose index and risk of hyperuricemia events in adults with hypertension
    Leixia Wang, Jianqian Chao, Na Zhang, Yanqian Wu, Min Bao, Chenyuan Yan, Tong Chen, Xinyue Li, Yiqin Chen
    Preventive Medicine Reports.2024; 43: 102763.     CrossRef
  • The association between triglyceride-glucose index and related parameters and risk of cardiovascular disease in American adults under different glucose metabolic states
    Yuansong Zhuang, Liliang Qiu, Dongjian Han, Zhentao Qiao, Fuhang Wang, Qingjiao Jiang, Quanxu An, Yuhang Li, Jiahong Shangguan, Xuanye Bi, Deliang Shen
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Recent advances in the effect of adipose tissue inflammation on insulin resistance
    Kaiyi Yan
    Cellular Signalling.2024; 120: 111229.     CrossRef
  • Umbilical Cord Mesenchymal Stem Cells Combined with Fufang Xueshuantong Capsule Attenuate Oxidative Stress and Vascular Lesions in Diabetic Rats by Activating Nrf-2/HO-1 Signaling Pathway
    Yunchao Sun, Yongzhang Li, Xueliang Gao, Limin Gao, Bingqi Yang, Jianing Zhao
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(8): 918.     CrossRef
  • Harnessing Metabolic Indices as a Predictive Tool for Cardiovascular Disease in a Korean Population without Known Major Cardiovascular Event
    Hyun-Jin Kim, Byung Sik Kim, Yonggu Lee, Sang Bong Ahn, Dong Wook Kim, Jeong-Hun Shin
    Diabetes & Metabolism Journal.2024; 48(3): 449.     CrossRef
  • Integrated insights into the synthesis and biological significances of novel benzofuran based oxadiazole/thiadiazole derivatives: A comprehensive computational and experimental study
    Hakimullah, Zahoor Ullah, Wajid Rehman, Mamoon Ur Rashid, Shoaib Khan, Rafaqat Hussain, Yousaf Khan, Tayyiaba Iqbal, Shifa Felemban, M.M. Khowdiary
    Journal of Molecular Structure.2024; 1314: 138726.     CrossRef
  • Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review
    Parisa Zare Mehrjerdi, Sara Asadi, Elham Ehsani, Vahid Reza Askari, Vafa Baradaran Rahimi
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(10): 7531.     CrossRef
  • Application of ERAS in older patients with gastric cancer
    Kuanxuan You, He Han
    Medicine.2024; 103(22): e38409.     CrossRef
  • Positive Effects of Physical Activity on Insulin Signaling
    Paulina Małkowska
    Current Issues in Molecular Biology.2024; 46(6): 5467.     CrossRef
  • Preventing High Fat Diet-Induced Obesity and Related Hepatic Steatosis by Chlorin e6-Mediated Photodynamic Therapy
    Pallavi Gurung, Junmo Lim, Yong-Wan Kim
    Pharmaceuticals.2024; 17(6): 729.     CrossRef
  • The Relationship Between Insulin Resistance Indicated by Triglyceride and Glucose Index and Left Ventricular Hypertrophy and Decreased Left Ventricular Diastolic Function with Preserved Ejection Fraction
    Chengzhang Yang, Weifang Liu, Zijia Tong, Fang Lei, Lijin Lin, Xuewei Huang, Xingyuan Zhang, Tao Sun, Gang Wu, Huajing Shan, Shaoze Chen, Hongliang Li
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2259.     CrossRef
  • Consumption of Chokeberry Bio-Products Improves Specific Metabolic Parameters and Increases the Plasma Antioxidant Status
    Ewa Olechno, Anna Puścion-Jakubik, Katarzyna Socha, Caterina Pipino, Małgorzata Elżbieta Zujko
    Antioxidants.2024; 13(6): 699.     CrossRef
  • The ketogenic diet and MetSyn in Parkinson’s disease – Symptoms, biomarkers, depression and anxiety: A case study
    Melanie M. Tidman
    Journal of Metabolic Health.2024;[Epub]     CrossRef
  • Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes
    Chengmeng Huang, Xiaolin Chen, Zedong Ouyang, Lingxue Meng, Jian Liu, Qihua Pang, Ruifang Fan
    Toxicology in Vitro.2024; 99: 105866.     CrossRef
  • A randomized double blind placebo controlled trial to assess the safety and efficacy of a patented fenugreek (Trigonella foenum-graecum) seed extract in Type 2 diabetics
    Rajinder Singh Gupta, Amarjit Singh Grover, Pawan Kumar, Apurva Goel, Samudra P. Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Partha Pal, Debasis Bagchi
    Food & Nutrition Research.2024;[Epub]     CrossRef
  • Ovalbumin Hydrolysates Enhance Skeletal Muscle Insulin-Dependent Signaling Pathway in High-Fat Diet-Fed Mice
    Nesma Elhadad, S. C. de Campos Zani, C. B. Chan, Jianping Wu
    Journal of Agricultural and Food Chemistry.2024; 72(27): 15248.     CrossRef
  • Effects of Preoperative Oral Carbohydrates on Recovery After Laparoscopic Cholecystectomy: A Meta-analysis of Randomized Controlled Trials
    Xiao-Han Wang, Ze-Yang Wang, Zheng-Ru Shan, Rui Wang, Zhi-Ping Wang
    Journal of PeriAnesthesia Nursing.2024;[Epub]     CrossRef
  • Metabolic Responses to High‐Fat Feeding and Chronic Psychological Stress Combination
    Marzieh Nemati, Fatemeh Rostamkhani, Roxana Karbaschi, Homeira Zardooz
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • Blue mussel (Mytilus edulis) lipid extract ameliorates insulin resistance in diabetic rats by regulating the SphK/So1P signaling pathway
    Xiaotong Kuang, Shiyi Liu, Huiying Li, Xiaolei Song, Xianfeng Shao, Kelei Li, Duo Li
    Journal of Functional Foods.2024; 119: 106307.     CrossRef
  • Association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with acute myocardial infarction: retrospective analysis of the MIMIC-IV database
    Chaodi Luo, Qian Li, Zhuoer Wang, Sifan Duan, Qiang Ma
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • High‐dose sinomenine attenuates ischemia/reperfusion‐induced hepatic inflammation and oxidative stress in rats with diabetes mellitus
    Bo Hui, Xiaogang Zhang, Dinghui Dong, Yantao Shu, Ren Li, Zhengan Yang
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • Endoplasmic reticulum stress in pancreatic β-cell dysfunctionality and diabetes mellitus: a promising target for generation of functional hPSC-derived β-cells in vitro
    Abdoulaye Diane, Asma Allouch, Razik Bin Abdul Mu-U-Min, Heba Hussain Al-Siddiqi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets
    Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng Li
    Biomedicine & Pharmacotherapy.2024; 177: 116917.     CrossRef
  • A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)-Associated Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation: Possible Links to Pregestational Prediabetes
    Mathuli Ngema, Nombuso D. Xulu, Phikelelani S. Ngubane, Andile Khathi
    Biomedicines.2024; 12(6): 1372.     CrossRef
  • The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective
    Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Peng
    BMC Women's Health.2024;[Epub]     CrossRef
  • Sodium–Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in the Lipid Metabolism and the Treatment of Chronic Kidney Disease Associated with Metabolic Syndrome
    Fernando Cortés-Camacho, Oscar René Zambrano-Vásquez, Elena Aréchaga-Ocampo, Jorge Ismael Castañeda-Sánchez, José Guillermo Gonzaga-Sánchez, José Luis Sánchez-Gloria, Laura Gabriela Sánchez-Lozada, Horacio Osorio-Alonso
    Antioxidants.2024; 13(7): 768.     CrossRef
  • The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance
    Hamish A. Deery, Emma Liang, Robert Di Paolo, Katharina Voigt, Gerard Murray, M. Navyaan Siddiqui, Gary F. Egan, Chris Moran, Sharna D. Jamadar
    Scientific Reports.2024;[Epub]     CrossRef
  • A comprehensive framework for managing metabolic dysfunction-associated steatotic liver disease: analyzing novel risk factors and advances in nanotechnology-based treatments and diagnosis
    Lucia M. Chávez-López, Gabriela I. Carballo-López, Karina del Carmen Lugo-Ibarra, Ana B. Castro-Ceseña
    RSC Medicinal Chemistry.2024; 15(8): 2622.     CrossRef
  • Effect of oral glucose tolerance test-based insulin resistance on embryo quality in women with/without polycystic ovary syndrome
    Zhengyan Hu, Rujun Zeng, Yuanting Tang, Yingjun Liao, Tao Li, Lang Qin
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Exogenous Nucleotides Ameliorate Insulin Resistance Induced by Palmitic Acid in HepG2 Cells through the IRS-1/AKT/FOXO1 Pathways
    Lixia Song, Yong Li, Meihong Xu
    Nutrients.2024; 16(12): 1801.     CrossRef
  • Putative mechanism of a multivitamin treatment against insulin resistance
    José Antonio Palma-Jacinto, Edgar López-López, José Luis Medina-Franco, Oreth Montero-Ruíz, Isela Santiago-Roque
    Adipocyte.2024;[Epub]     CrossRef
  • Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies
    Yu Luo, Dan Luo, Maojun Li, Binzhi Tang, Robert P. Hoffman
    Pediatric Diabetes.2024;[Epub]     CrossRef
  • Lysophosphatidylcholine trigger myocardial injury in diabetic cardiomyopathy via the TLR4/ZNF480/AP-1/NF-kB pathway
    Nannan Liu, Yang Chen, Tian An, Siyu Tao, Bohan Lv, Jinfang Dou, Ruxue Deng, Xianjie Zhen, Yuelin Zhang, Caizhong Lu, Zhongsheng Chang, Guangjian Jiang
    Heliyon.2024; 10(13): e33601.     CrossRef
  • John Yudkin’s hypothesis: sugar is a major dietary culprit in the development of cardiovascular disease
    Kenneth K.Y. Ting
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients
    Wenfeng Gong, Wenzhe Chen, Jianjun Dong, Lin Liao
    Journal of the Endocrine Society.2024;[Epub]     CrossRef
  • Triglyceride glucose-related indexes and lipid accumulation products—reliable markers of insulin resistance in the Chinese population
    Lei Liu, Yufang Luo, Min Liu, Chenyi Tang, Hong Liu, Guo Feng, Meng Wang, Jinru Wu, Wei Zhang
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Exploring the active components and potential mechanisms of Alpiniae oxyphyllae Fructus in treating diabetes mellitus with depression by UPLC-Q-Exactive Orbitrap/MS, network pharmacology and molecular docking
    Yue Qi, Qilun Zhou, Yongping Zhang, Jinlan Deng, Ruonan Li, Xiaofeng Zhang
    Metabolic Brain Disease.2024; 39(6): 1065.     CrossRef
  • A λ-Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor
    Monica P. Barron, Jonah Z. Vilseck
    Journal of Chemical Information and Modeling.2024; 64(14): 5657.     CrossRef
  • The dichloromethane fraction from Calotropis gigantea (L.) dryand. Stem bark extract prevents liver cancer in SDT rats with insulin-independent diabetes mellitus
    Thaiyawat Haewphet, Supawadee Parhira, Pattaraporn Chaisupasakul, Apirath Wangteeraprasert, Ittipon Phoungpetchara, Dumrongsak Pekthong, Worasak Kaewkong, Zhi-Hong Jiang, Li-Ping Bai, Julintorn Somran, Piyarat Srisawang
    Journal of Ethnopharmacology.2024; 334: 118516.     CrossRef
  • Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients
    Wei Wang, Yingqi Zhang, Wei Yao, Wanyun Tang, Yuhao Li, Hongbo Sun, Wenbo Ding
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Association between the triglyceride glucose index and the risk of acute kidney injury in critically ill patients with hypertension: analysis of the MIMIC-IV database
    Wenbin Zhang, Zewen Yang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity
    Mohammad Muzaffar Mir, Jaber Alfaifi, Shahzada Khalid Sohail, Syeda Fatima Rizvi, Md Tanwir Akhtar, Mushabab Ayed Abdullah Alghamdi, Rashid Mir, Javed Iqbal Wani, Zia Ul Sabah, Fahad A. Alhumaydhi, Fahad Alremthi, AbdulElah Al Jarallah AlQahtani, Muffarah
    Journal of Personalized Medicine.2024; 14(7): 743.     CrossRef
  • Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus
    Qianyu Chen, Xiaoqin Zhao, Zujie Xu, Yiyao Liu
    Biomedicine & Pharmacotherapy.2024; 177: 117122.     CrossRef
  • Advances in Nanomedicine for Precision Insulin Delivery
    Alfredo Caturano, Roberto Nilo, Davide Nilo, Vincenzo Russo, Erica Santonastaso, Raffaele Galiero, Luca Rinaldi, Marcellino Monda, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
    Pharmaceuticals.2024; 17(7): 945.     CrossRef
  • Association between triglyceride glucose body mass index and cardiovascular disease in adults: evidence from NHANES 2011- 2020
    Run Wang, Xiaobing Cheng, Weijun Tao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis
    Nhlakanipho Mzimela, Nosipho Dimba, Aubrey Sosibo, Andile Khathi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications
    Zhen Wang, Huadong Liu
    Biomolecules.2024; 14(7): 862.     CrossRef
  • Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9
    Zhao Qian, Liu Ping, Xu Dongming, Zhang Xuelin
    Medicine.2024; 103(29): e38855.     CrossRef
  • Common Denominator of MASLD and Some Non-Communicable Diseases
    Katarzyna Ferenc, Sara Jarmakiewicz-Czaja, Aneta Sokal-Dembowska, Katarzyna Stasik, Rafał Filip
    Current Issues in Molecular Biology.2024; 46(7): 6690.     CrossRef
  • Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation
    Xiaolei Miao, Arian Alidadipour, Vian Saed, Firooze Sayyadi, Yasaman Jadidi, Maryam Davoudi, Fatemeh Amraee, Nastaran Jadidi, Reza Afrisham
    Acta Diabetologica.2024; 61(11): 1339.     CrossRef
  • The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside
    Xiaofei Shen, Hongling Yang, Yang Yang, Xianjun Zhu, Qingxiang Sun
    MedComm.2024;[Epub]     CrossRef
  • Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies
    Rani Elkanawati, Sri Sumiwi, Jutti Levita
    Drug Design, Development and Therapy.2024; Volume 18: 3337.     CrossRef
  • Cysteine‐rich 61 inhibition attenuates hepatic insulin resistance and improves lipid metabolism in high‐fat diet fed mice and HepG2 cells
    Yu Jung Heo, Jieun Park, Nami Lee, Sung‐E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Kwan Woo Lee, Hae Jin Kim
    The FASEB Journal.2024;[Epub]     CrossRef
  • Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis
    Menglu Wu, Yongyi Cheng, Ruolin Zhang, Wenwen Han, Hanqi Jiang, Chenchen Bi, Ziyi Zhang, Mengfei Ye, Xiuqin Lin, Zheng Liu
    Biomedicine & Pharmacotherapy.2024; 178: 117228.     CrossRef
  • Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity
    Xiaorui Yu, Jiawang Tao, Yuhang Wu, Yan Chen, Penghui Li, Fan Yang, Miaoxiu Tang, Abdul Sammad, Yu Tao, Yingying Xu, Yin-Xiong Li
    Diabetes & Metabolism Journal.2024; 48(4): 802.     CrossRef
  • Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults
    Hamish A. Deery, Emma Liang, Robert Di Paolo, Katharina Voigt, Gerard Murray, M. Navyaan Siddiqui, Gary F. Egan, Chris Moran, Sharna D. Jamadar
    npj Metabolic Health and Disease.2024;[Epub]     CrossRef
  • Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
    Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
    Diabetes & Metabolism Journal.2024; 48(4): 487.     CrossRef
  • mTOR Dysregulation, Insulin Resistance, and Hypertension
    Silviu Marcel Stanciu, Mariana Jinga, Daniela Miricescu, Constantin Stefani, Remus Iulian Nica, Iulia-Ioana Stanescu-Spinu, Ileana Adela Vacaroiu, Maria Greabu, Silvia Nica
    Biomedicines.2024; 12(8): 1802.     CrossRef
  • Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives
    Aarti Nagayach, Rakesh Bhaskar, Shampa Ghosh, Krishna Kumar Singh, Sung Soo Han, Jitendra Kumar Sinha
    Ageing Research Reviews.2024; 100: 102450.     CrossRef
  • Impact of Smoking and Obesity on the Selected Peptide Hormones and Metabolic Parameters in the Blood of Women with Polycystic Ovary Syndrome—Preliminary Study
    Justyna Niepsuj, Agnieszka Piwowar, Grzegorz Franik, Anna Bizoń
    International Journal of Molecular Sciences.2024; 25(16): 8713.     CrossRef
  • Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study
    Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • In vitro digestive properties and the bioactive effect of walnut green husk on human gut microbiota
    Xiaolan Zhao, Jiabao Ying, Zhuochen Wang, Yulu Wang, Zhen Li, Tianyi Gu, Shujun Liu, Yulong Li, Bing Liu, Fengjiao Xin, Boting Wen
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose
    Sheng Li, Yiqing Wang, Xiangyi Zhu, He Zheng, Jianqiang Ni, Hao Li, Yi Yang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Impact of Rice Bran Oil Emulsified Formulation on Digestion and Glycemic Response to Japonica Rice: An In Vitro Test and a Clinical Trial in Adult Men
    Naoki Kawada, Keiko Kamachi, Masatsugu Tamura, Maki Tamura, Rika Kitamura, Kenta Susaki, Hiroyoshi Yamamoto, Hideaki Kobayashi, Ryosuke Matsuoka, Osamu Ishihara
    Foods.2024; 13(16): 2628.     CrossRef
  • Plant but not animal sourced nitrate intake is associated with lower dementia-related mortality in the Australian Diabetes, Obesity, and Lifestyle Study
    Anjana Rajendra, Nicola P. Bondonno, Liezhou Zhong, Simone Radavelli-Bagatini, Kevin Murray, Stephanie R. Rainey-Smith, Samantha L. Gardener, Lauren C. Blekkenhorst, Dianna J. Magliano, Jonathan E. Shaw, Robin M. Daly, Kaarin J. Anstey, Joshua R. Lewis, J
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • İnsülin Direncinin Beslenme Tedavisinde Güncel Diyet Modelleri
    Meryem Köpürlü, Elif Ede Çintesun
    İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi.2024; 6(1): 5.     CrossRef
  • Structural characterization, physicochemical properties and hypoglycemic activity of soluble dietary fibers from salt stressed mung bean sprouts
    Cong Teng, Jinge Liu, Suling Li, Kaiyang Ma, Lujing Xu, Jin Feng, Zhi Chai, Xindi Hu, Yifei Lu, Ying Li
    International Journal of Biological Macromolecules.2024; 278: 134979.     CrossRef
  • The synergistic effect of triglyceride-glucose index and HbA1c on blood pressure control in patients with hypertension: a retrospective cohort study
    Yugang Han, Jinghan Hai, Xiaojun Yang, Dongyue Lu, Jingyuan Li, Xuefang Yan, Peili Bu, Yun Ti, Xiaofeng Li
    Scientific Reports.2024;[Epub]     CrossRef
  • Nitric oxide in modulating oxidative stress mediated skeletal muscle insulin resistance
    Aamir Anwar, Shivang Shukla, Priya Pathak
    Molecular Biology Reports.2024;[Epub]     CrossRef
  • Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance
    Xiaoguang Liu, Lin Zhu, Jingxin Liu, Zichen Nie, Wenjun Qiu
    Amino Acids.2024;[Epub]     CrossRef
  • Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study
    Yang Li, Yahu Miao, Qing Feng, Weixi Zhu, Yijing Chen, Qingqing Kang, Zhen Wang, Fangting Lu, Qiu Zhang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Molecular Aspects in the Development of Type 2 Diabetes and Possible Preventive and Complementary Therapies
    Laura Simon-Szabó, Beáta Lizák, Gábor Sturm, Anikó Somogyi, István Takács, Zsuzsanna Németh
    International Journal of Molecular Sciences.2024; 25(16): 9113.     CrossRef
  • Effect of irisin on ovarian phosphatidylinositol‐3‐kinase/protein kinase B signaling pathway and mitogen‐activated protein kinase/extracellular signal‐regulated kinase pathways of rats with polycystic ovary syndrome
    Cheng‐gang Li, Li Zhou, Ying‐jun Zhang, Yong Li, Li‐yan Zhao
    Journal of Obstetrics and Gynaecology Research.2024; 50(10): 1945.     CrossRef
  • Linear positive association of metabolic score for insulin resistance with stroke risk among American adults: a cross-sectional analysis of National Health and Nutrition Examination Survey datasets
    Ruwen Zheng, Xu Dong, Tianyi Wang, Hongyan Zhang, Yihao Zhou, Dongyan Wang
    Journal of Stroke and Cerebrovascular Diseases.2024; 33(11): 107994.     CrossRef
  • Glycemic Control and Retinal Microvascular Changes in Type 2 Diabetes Mellitus Patients without Clinical Retinopathy
    Kangmin Lee, Ga Hye Lee, Seung Eun Lee, Jee Myung Yang, Kunho Bae
    Diabetes & Metabolism Journal.2024; 48(5): 983.     CrossRef
  • The Predictive Value of the Triglycerides/HDL-Cholesterol Ratio for Diabetes Incidence
    Bianca de Almeida-Pititto, Julia Ines Branda, Julia M. de Oliveira, Patrícia M. Dualib, Luisa Bittencourt de Aquino Fernandes Dias, Isabela M. Bensenor, Paulo A. Lotufo, Sandra Roberta G. Ferreira
    Endocrines.2024; 5(3): 418.     CrossRef
  • Associations of total protein, albumin, and globulin with insulin resistance: an NHANES study
    Rui-Xiang Zeng, Jun-Peng Xu, Yu-Zhuo Zhang, Jia-Wei Tan, Yong-Jie Kong, Min-Zhou Zhang, Li-Heng Guo
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey
    Zhiming Lu, Yaoda Hu, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Binbin Lin, Qihang Liu, Tianshu Xi, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Huijing He, Guangliang Shan
    Nutrition Journal.2024;[Epub]     CrossRef
  • Genistein mitigates diet-induced obesity and metabolic dysfunctions in gonadectomized mice with some sex-differential effects
    Weerapat Kositanurit, Natakorn Siritaweechai, Pachara Varachotisate, Chuti Burana, Narittee Sukswai, Jerasit Surintrspanont, Prasong Siriviriyakul, Kasiphak Kaikaew, Duangporn Werawatganon
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Initiating non-insulin-based treatment in adults with type 2 diabetes: a practical guide
    Martha Stewart
    Primary Health Care.2024;[Epub]     CrossRef
  • Therapeutic Potential of Luteolin for Diabetes Mellitus and Its Complications
    Xiao-qin Chang, Ren-song Yue
    Chinese Journal of Integrative Medicine.2024;[Epub]     CrossRef
  • Licochalcone D from Glycyrrhiza uralensis Improves High-Glucose-Induced Insulin Resistance in Hepatocytes
    Yu Geon Lee, Hee Min Lee, Jin-Taek Hwang, Hyo-Kyoung Choi
    International Journal of Molecular Sciences.2024; 25(18): 10066.     CrossRef
  • The emerging role of nanoscaffolds in chronic diabetic wound healing: a new horizon for advanced therapeutics
    Mehmet Ali Tibatan, Dzana Katana, Casey M. Yin
    Journal of Biomaterials Science, Polymer Edition.2024; : 1.     CrossRef
  • Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review
    Adekunle Babajide Rowaiye , Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua , Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu
    Academia Biology.2024;[Epub]     CrossRef
  • Influence of Type 2 Diabetes and Adipose Tissue Dysfunction on Breast Cancer and Potential Benefits from Nutraceuticals Inducible in Microalgae
    Domenico Sergi, Mattia Melloni, Angelina Passaro, Luca Maria Neri
    Nutrients.2024; 16(19): 3243.     CrossRef
  • Oxygen-Dependent Aspects of the Action of Asprosyn
    V. V. Zinchuk, J. S. O. Al-Jebur
    Rossijskij fiziologičeskij žurnal im. I.M. Sečenova.2024; 110(4): 547.     CrossRef
  • How Can Promoting Skeletal Muscle Health and Exercise in Children and Adolescents Prevent Insulin Resistance and Type 2 Diabetes?
    Valeria Calcaterra, Vittoria Carlotta Magenes, Alice Bianchi, Virginia Rossi, Alessandro Gatti, Luca Marin, Matteo Vandoni, Gianvincenzo Zuccotti
    Life.2024; 14(9): 1198.     CrossRef
  • Association between cardiometabolic index and gestational diabetes mellitus: a cross-sectional study
    Minchun Chen, Suqiang Xiong, Jie Zheng, Jingyi Zhang, Dan Ye, Yusan Xian, Qing Cao, Kangkang Yan
    Endocrine.2024;[Epub]     CrossRef
  • Association between diabetes mellitus and ossification of the spinal ligament: a systematic review and meta-analysis
    Bowen Lai, Yuan Gao, Yichen Meng, Rui Gao, Heng Jiang, Xuhui Zhou
    Neurosurgical Review.2024;[Epub]     CrossRef
  • Association of Insulin Resistance and Ectopic Fat Accumulation with HOMA Indices: A Single-Centre Observational Study
    Sevde Nur Emir, Servet Emir
    Turkish Journal of Diabetes and Obesity.2024; 8(2): 97.     CrossRef
  • Enteropancreatic hormone changes in caloric-restricted diet interventions associate with post-intervention weight maintenance
    Huibin Lin, Qiaoling Wang, Aibo Gao, Yingkai Sun, Chongrong Shen, Yufei Chen, Zhifeng Wang, Xiaoqiang Xu, Mengshan Ni, Yanru Chen, Juan Zhang, Yaogan Luo, Xu Lin, Yufang Bi, Guang Ning, Weiqing Wang, Jie Hong, Weiqiong Gu, Jiqiu Wang, Ruixin Liu
    Clinical Nutrition.2024; 43(12): 5.     CrossRef
  • Research Progress of the Correlation between Insulin Resistance and Its Novel Evaluation Indicators with Cardiovascular Disease
    高华 蒲
    Advances in Clinical Medicine.2024; 14(10): 76.     CrossRef
  • Hypoglycemic Effect of Rambutan (Nephelium lappaceum L.) Peel Polyphenols on Type 2 Diabetes Mice by Modulating Gut Microbiota and Metabolites
    Qiuming Liu, Qingyu Ma, Jiao Li, Liping Sun, Yongliang Zhuang
    Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
  • Gender Differences in the Predictive Value of Obesity Indices for Insulin Resistance in Adult Mexican Individuals
    Elizalde-Barrera Cesar Ivan, Estrada-Garcia Teresa, Lopez-Saucedo Catalina, Rubio-Guerra Alberto Francisco, Ramirez-Velasco Diana Elena
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(14): 1640.     CrossRef
  • Association between Dietary Antioxidants and Atherosclerotic Cardiovascular Disease in South Korea: Insights from a Comprehensive Cross-Sectional Analysis
    Jong-Ho Kim, Myeong Eun Lee, Sung-Mi Hwang, Jae-Jun Lee, Young-Suk Kwon
    Journal of Clinical Medicine.2024; 13(20): 6068.     CrossRef
  • Role of Akkermansia muciniphila in insulin resistance
    Zhijun Zeng, Mengjie Chen, Yimin Liu, Yun Zhou, Hongning Liu, Shaohua Wang, Yanhua Ji
    Journal of Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Elevated non-HDL-C to HDL-C ratio as a marker for NAFLD and liver fibrosis risk: a cross-sectional analysis
    Yanyan Xuan, Minghui Zhu, Linzhi Xu, Shujiao Huangfu, Tongyu Li, Chunbo Liu, Dongdong Zhou
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner
    Na Liu, Xin Cui, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Jieyun Liu, Yangyang Zhang, Weina Ma, Wenhui Yan, Lina Chen
    Antioxidants.2024; 13(10): 1246.     CrossRef
  • Insulin
    Wenqiang Chen, C. Ronald Kahn
    Trends in Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Prevalence of Functional Cobalamin Deficiency and Relevant Mortality Risk in the General Population: An Unheeded Phenotype Distinct from Cobalamin Deficiency
    Yan Liu, Yi Gao, Yige Liu, Yiying Zhang, Shanjie Wang, Bo Yu
    Journal of the American Nutrition Association.2024; : 1.     CrossRef
  • Interaction between green tea and metformin and its effects on oxidative stress and inflammation in overweight women: a randomised clinical trial
    Carolina de Oliveira Vogado, Monalisa Alves Ferreira, Eduardo Yoshio Nakano, Sabrina Azevedo, Kelly Grace Magalhães, Sandra Fernandes Arruda, Patrícia Borges Botelho
    British Journal of Nutrition.2024; : 1.     CrossRef
  • The protective effects of fisetin in metabolic disorders: a focus on oxidative stress and associated events
    Mahboobe Sattari, Jamal Amri, Mohammad Esmaeil Shahaboddin, Mohadese Sattari, Ozra Tabatabaei-Malazy, Marzyeh Azmon, Reza Meshkani, Ghodratollah Panahi
    Journal of Diabetes & Metabolic Disorders.2024;[Epub]     CrossRef
  • Early impaired insulin tolerance among Vietnamese diabetes with or without dyslipidemia
    Mai Ly Thi Nguyen, Khac Cuong Bui, Thu Hang Ngo, Tai Suc Nguyen, Phuong Linh Thi Nham, Chi Pham, Thi Minh Hoang, Quang Thuan Huynh, Thanh Thuy Tang, Thanh Chung Dang, Thuy Linh Dang, Linh Toan Nguyen, Van Mao Can
    Medicine.2024; 103(44): e40212.     CrossRef
  • Exploration and identification of diabetes targets in nursing: CDH1 and DVL1
    Fei Cheng, Lixia Li, Yanting Zhang
    Medicine.2024; 103(44): e40002.     CrossRef
  • KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle
    Shuying Fu, Xiaocheng Gong, Keying Liang, Ke Ding, Li Qiu, Huice Cen, Hongli Du
    American Journal of Physiology-Cell Physiology.2024; 327(5): C1219.     CrossRef
  • Development and validation of a predictive scoring system for hypoglycaemic agents for optimal control of blood glucose during glucocorticoid therapy
    Ayaka Kato, Masayuki Fuwa, Motochika Asano, Ichiro Mori, Saori Iida, Hideyuki Okada, Yoshihiro Uno, Kei Fujioka, Hiroyuki Morita
    Internal Medicine Journal.2024;[Epub]     CrossRef
  • Correlation between portal hypertension and somatic constitution: rationale behind the concept
    Yury O. Zharikov, Ilia A. Voloshin, Roman V. Maslennikov, Aida N. Gadzhiakhmedova, Tatiana S. Zharikova, Vladimir N. Nikolenko
    Science and Innovations in Medicine.2024;[Epub]     CrossRef
  • The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis
    Zhitong Li, Shiwei Liu, Xingyu Li, Jinchang Liu, Xin Li, Yuxiang Zhao, Yongliang Feng
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside
    Candelas Gross‐Valle, Tessa C. Jacobs, Janneke D. A. Dijck‐Brouwer, Janniek Lubberts, Barbara M. Bakker, Stephan J. L. Bakker, Yvonne van der Veen, Andrea B. Schreuder, Terry G. J. Derks, Jennifer van der Krogt, Joost Groen, M. Rebecca Heiner‐Fokkema
    Journal of Inherited Metabolic Disease.2024;[Epub]     CrossRef
  • Varicose vein disease in the context of insulin resistance
    Valeria Korolenya, Maxim Filipenko, Mariya Smetanina
    Vessel Plus.2024;[Epub]     CrossRef
  • Association of triglyceride-glucose index, low and high-density lipoprotein cholesterol with all-cause and cardiovascular disease mortality in generally Chinese elderly: a retrospective cohort study
    Donghai Su, Zhantian An, Liyuan Chen, Xuejiao Chen, Wencan Wu, Yufang Cui, Yulin Cheng, Songhe Shi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Targeting histamine in metabolic syndrome: Insights and therapeutic potential
    Yiting Wang, Fude Fang, Xiaojun Liu
    Life Sciences.2024; 358: 123172.     CrossRef
  • Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway
    Sisi Lei, Weihang Peng, Lulu Wu, Liyuan Yu, Meida Wang, Qingmin Li, Yi Deng, Shuai Zhao, Peiying Huang, Bojun Chen
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Acupuncture, a Promising Therapy for Insulin Resistance and Non-Alcoholic Fatty Liver Disease
    Hui Li, Dan Wang
    International Journal of General Medicine.2024; Volume 17: 4917.     CrossRef
  • Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics
    Gihan F. Asaad, Ahmed S. Doghish, Ahmed A. Rashad, Walaa A. El-Dakroury
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub]     CrossRef
  • Prevalence of Metabolic Syndrome and Insulin Resistance in Adult Patients with Acne: Association with Traditional Cardiovascular Risk Factors and Acne Severity
    Ana Cecília Arcanjo Carneiro, Jozélio Freire de Carvalho, Daniel Coelho de Sá, Carlos Ewerton Maia Rodrigues
    Metabolic Syndrome and Related Disorders.2023; 21(2): 109.     CrossRef
  • Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance
    Najeebul Tarfeen, Khair Ul Nisa, Mir Bilal Ahmad, Ajaz Ahmad Waza, Bashir Ahmad Ganai
    Indian Journal of Clinical Biochemistry.2023; 38(4): 407.     CrossRef
  • Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport through Both PI-3-Kinase- and AMPK-Dependent Mechanisms
    Akansha Mishra, Khushbu Sharma, Jyotsana Pandey, Kapil Dev, Sleman Kadan, Mahendra Sahai, Ishbal Ahmad, Arvind K. Srivastava, Akhilesh K. Tamrakar, Hilal Zaid, Rakesh Maurya
    Molecules.2023; 28(2): 483.     CrossRef
  • Pathophysiology of obesity and its associated diseases
    Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud, Tao Jiang
    Acta Pharmaceutica Sinica B.2023; 13(6): 2403.     CrossRef
  • Hypertension, type 2 diabetes, obesity, and p53 mutations negatively correlate with metastatic colorectal cancer patients’ survival
    Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Francesco Perri, Marco Cascella, Francesco Sabbatino, Maurizio Capuozzo, Vincenza Granata, Silvia Zappavigna, Angela Lombardi, Marianna Scrima, Nadia Petrillo, Monica Ianniello, Marika Casillo,
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Triglyceride glucose index and poor sleep patterns in non-diabetic adults: Evidence from NHANES 2005–2016
    Chi-Feng Liu, Li-Wei Chien
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Polyphenol-Rich Extract of Fermented Chili Pepper Alleviates Insulin Resistance in HepG2 Cells via Regulating INSR, PTP1B, PPAR-γ, and AMPK Pathways
    Tao Wang, Meiqi Li, Shengbao Cai, Linyan Zhou, Xiaosong Hu, Junjie Yi
    Fermentation.2023; 9(2): 84.     CrossRef
  • Effects of preoperative oral enzyme-hydrolyzed rice flour solution on gastric emptying and insulin resistance in patients undergoing laparoscopic cholecystectomy: a prospective randomized controlled trial
    Yang Yuan, Guangjun Shi, Huailong Chen, Mingshan Wang, Haofei Liu, Xiao Zhang, Bin Wang, Gaofeng Zhang, Lixin Sun
    BMC Anesthesiology.2023;[Epub]     CrossRef
  • Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
    Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Jerilee M. K. Azhary, Nozomi Takahashi, Yoko Urata, Yutaka Osuga
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The Metabolic Score for Insulin Resistance (METS-IR) Predicts Cardiovascular Disease and Its Subtypes in Patients with Hypertension and Obstructive Sleep Apnea
    Wenbo Yang, Xintian Cai, Junli Hu, Wen Wen, Heizhati Mulalibieke, Xiaoguang Yao, Ling Yao, Qing Zhu, Jing Hong, Qin Luo, Shasha Liu, Nanfang Li
    Clinical Epidemiology.2023; Volume 15: 177.     CrossRef
  • Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature
    Andrew Peel, Anmol Saini, Joshua C. Deluao, Nicole O. McPherson
    Andrology.2023; 11(8): 1635.     CrossRef
  • Glucose Homeostasis, Diabetes Mellitus, and Gender-Affirming Treatment
    Charalampos Milionis, Ioannis Ilias, Evangelia Venaki, Eftychia Koukkou
    Biomedicines.2023; 11(3): 670.     CrossRef
  • From Metabolic Syndrome to Type 2 Diabetes in Youth
    Dario Iafusco, Roberto Franceschi, Alice Maguolo, Salvatore Guercio Nuzio, Antonino Crinò, Maurizio Delvecchio, Lorenzo Iughetti, Claudio Maffeis, Valeria Calcaterra, Melania Manco
    Children.2023; 10(3): 516.     CrossRef
  • Kcnma1 is involved in mitochondrial homeostasis in diabetes‐related skeletal muscle atrophy
    Shan‐Yan Gao, Yong‐Ping Liu, Ri Wen, Xin‐Mei Huang, Ping Li, Yu‐Hang Yang, Ni Yang, Tie‐Ning Zhang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes
    Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
    Molecules.2023; 28(6): 2861.     CrossRef
  • Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption
    Keiko Unno, Kyoko Taguchi, Yoshiichi Takagi, Tadashi Hase, Shinichi Meguro, Yoriyuki Nakamura
    International Journal of Molecular Sciences.2023; 24(7): 6278.     CrossRef
  • Association between triglyceride-glucose index and carotid atherosclerosis in patients with psoriatic arthritis
    Wenhui Xie, Wei Bian, Zhibo Song, Xuerong Deng, Jiahao Qu, Zhuoli Zhang
    Rheumatology.2023; 62(11): 3584.     CrossRef
  • The relationship between HMGB1 and autophagy in the pathogenesis of diabetes and its complications
    Kun Yang, Feng Cao, Weili Wang, Zhenyu Tian, Lu Yang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases
    Wenqi Xu, Haiyan Zhao, Lishu Gao, Lu Guo, Jianrong Liu, Haixia Li, Junyan Sun, Aijun Xing, Shuohua Chen, Shouling Wu, Yuntao Wu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
    Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
    Nutrients.2023; 15(7): 1722.     CrossRef
  • Soy protein compared with whey protein ameliorates insulin resistance by regulating lipid metabolism, AMPK/mTOR pathway and gut microbiota in high-fat diet-fed mice
    Andong Ji, Wei Chen, Chang Liu, Tianyu Zhang, Runjia Shi, Xinqi Wang, Huina Xu, Duo Li
    Food & Function.2023; 14(12): 5752.     CrossRef
  • Hepatic Insulin Resistance Model in the Male Wistar Rat Using Exogenous Insulin Glargine Administration
    Victor Enrique Sarmiento-Ortega, Diana Moroni-González, Alfonso Diaz, Miguel Ángel García-González, Eduardo Brambila, Samuel Treviño
    Metabolites.2023; 13(4): 572.     CrossRef
  • Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome
    Jim Parker
    Life.2023; 13(4): 1056.     CrossRef
  • Metabolic dysfunction correction as a method of restoring the function of the reproductive system in women
    G. E. Chernukha, V. A. Pronina
    Meditsinskiy sovet = Medical Council.2023; (5): 90.     CrossRef
  • Associations between TyG-BMI and normal-high blood pressure values and hypertension: cross-sectional evidence from a non-diabetic population
    Nan Peng, Maobin Kuang, Yi Peng, Hang Yu, Shuhua Zhang, Guobo Xie, Guotai Sheng, Yang Zou
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais
    Natnicha Promyos, Pornpimol Panprathip Phienluphon, Naruemon Wechjakwen, Jirayu Lainampetch, Pattaneeya Prangthip, Karunee Kwanbunjan
    Nutrients.2023; 15(9): 2071.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • Oxygen-binding properties of blood in insulin resistance with different asprosin content
    V.V. Zinchuk, J.S.O. Al-Jebur, N.V. Glutkina
    Biomeditsinskaya Khimiya.2023; 69(2): 133.     CrossRef
  • Associations between basal metabolic rate and insulin resistance in non-diabetic obese adults: Evidence from NHANES 2011–2018
    Hai Guo, Dilihumaier Duolikun, Qiaoling Yao
    International Journal of Diabetes in Developing Countries.2023; 43(6): 946.     CrossRef
  • Biomarkers of Spinal Cord Injury in Patients Undergoing Complex Endovascular Aortic Repair Procedures—A Narrative Review of Current Literature
    Anna Sotir, Johannes Klopf, Christine Brostjan, Christoph Neumayer, Wolf Eilenberg
    Biomedicines.2023; 11(5): 1317.     CrossRef
  • The Hypoglycemic Activities and Underlying Mechanisms of Two Saponins‐Rich Components from Fried Ziziphus jujuba Mill. Kernel
    Yi‐Meng Li, Ke‐xin Hao, Hong Xie, Jian‐Guo Jiang
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia
    Yi-Shang Yan, Chun Feng, Dan-Qing Yu, Shen Tian, Yin Zhou, Yi-Ting Huang, Yi-Ting Cai, Jian Chen, Miao-Miao Zhu, Min Jin
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
    Byungyong Ahn
    International Journal of Molecular Sciences.2023; 24(10): 8811.     CrossRef
  • An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus
    Mohamed Omer Mahgoub, Ifrah Ismail Ali, Jennifer O. Adeghate, Kornélia Tekes, Huba Kalász, Ernest A. Adeghate
    International Journal of Molecular Sciences.2023; 24(11): 9328.     CrossRef
  • Study on the therapeutic effect and mechanism of Tangningtongluo Tablet on diabetic mice
    Zengxiaorui Cai, Xiangka Hu, Liuming Gui, Mushuang Qi, Wanjun Zhu, Ying Ren, Shuyu Yang, Chunmei Dai
    Journal of Diabetes and its Complications.2023; 37(8): 108523.     CrossRef
  • A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention
    Paolo Bellavite, Serafino Fazio, Flora Affuso
    Molecules.2023; 28(11): 4491.     CrossRef
  • Relationships of neck circumference and abdominal obesity with insulin resistance considering relative handgrip strength in middle-aged and older individuals
    Kayoung Lee
    Archives of Gerontology and Geriatrics.2023; 114: 105097.     CrossRef
  • Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress
    Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Selene Elizabeth Herrera-Vázquez, Karina Elisa Rosales-Pérez, Nely SanJuan-Reyes, Sandra García-Medina, Marcela Galar-Martínez
    Aquatic Toxicology.2023; 261: 106610.     CrossRef
  • Gαi‐coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals
    Do‐Hyung Lee, Kyung‐Sun Heo, Chang‐Seon Myung
    Obesity.2023; 31(7): 1871.     CrossRef
  • Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice
    Saori Kakehi, Yoshifumi Tamura, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watada
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Metabolic-Associated Fatty Liver Disease and Insulin Resistance: A Review of Complex Interlinks
    Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
    Metabolites.2023; 13(6): 757.     CrossRef
  • Metabolic Markers Associated with Progression of Type 2 Diabetes Induced by High-Fat Diet and Single Low Dose Streptozotocin in Rats
    Maria Andonova, Petko Dzhelebov, Krastina Trifonova, Penka Yonkova, Nikola Kostadinov, Krasimira Nancheva, Veselin Ivanov, Krasimira Gospodinova, Nikola Nizamov, Ilia Tsachev, Chavdar Chernev
    Veterinary Sciences.2023; 10(7): 431.     CrossRef
  • Research Progress Into Adipose Tissue Macrophages and Insulin Resistance
    M Fu, L Yang, H Wang, Y Chen, X Chen, Q Hu, H Sun
    Physiological Research.2023;[Epub]     CrossRef
  • Effects of aerobic exercises in prediabetes patients: a systematic review and meta-analysis
    Yifei Wang, Honglei Li, Dongxue Yang, Mengzhao Wang, Yanbai Han, Hongli Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Associations of C-peptide with cardiometabolic parameters in women aged 25–44 years with different metabolic phenotypes
    S. V. Mustafina, V. I. Alferova, L. V. Shcherbakova, E. V. Kashtanova, D. V. Denisova
    Ateroscleroz.2023; 19(2): 115.     CrossRef
  • Adipose-derived Mesenchymal Stem Cells Therapy as a new Treatment Option for Diabetes Mellitus
    Agnieszka Mikłosz, Adrian Chabowski
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(8): 1889.     CrossRef
  • Anthropometric Indices With Insulin Resistance in Obese Patients: A Literature Review
    Khalid Khan, Anil Wanjari, Sourya Acharya, Sabiha Quazi
    Cureus.2023;[Epub]     CrossRef
  • Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Yiming Cao, Xiaoxue Fang, Mingyang Sun, Yegang Zhang, Mengyao Shan, Xintian Lan, Difu Zhu, Haoming Luo
    Phytotherapy Research.2023; 37(9): 3867.     CrossRef
  • Tuina (Chinese massage) for insulin resistance and sensitivity: A protocol for systematic review and meta-analysis of animal and human studies
    Zhixuan Zhao, Jun Yan, Yuxin Ding, Yingji Wang, Yan Li, Ricardo Ney Oliveira Cobucci
    PLOS ONE.2023; 18(7): e0288414.     CrossRef
  • Rubus chingii Hu relieved the polycystic ovary syndrome with enhanced insulin sensitivity through inhibiting TXNIP/NLRP3 inflammasome signaling
    Huizhen Li, Yongping Li, Ying Zhang, Li Tong, Yuping Sa, Wenping Sun
    Gynecological Endocrinology.2023;[Epub]     CrossRef
  • The Research Role of Triglyceride Glucose Index in Pre-Type 2 Diabetes
    士博 徐
    Advances in Clinical Medicine.2023; 13(07): 11762.     CrossRef
  • Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice
    Xing Wang, Dongmei Long, Xianghong Hu, Nan Guo
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Review of the Case Reports on Metformin, Sulfonylurea, and Thiazolidinedione Therapies in Type 2 Diabetes Mellitus Patients
    Elis Susilawati, Jutti Levita, Yasmiwar Susilawati, Sri Adi Sumiwi
    Medical Sciences.2023; 11(3): 50.     CrossRef
  • Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation
    Zhen Fan, Rui Chen, Wen Yin, Xiaomei Xie, Shan Wang, Chunbo Hao
    Viral Immunology.2023; 36(7): 438.     CrossRef
  • PREDICTING PROGRESSION TYPE 2 DIABETES MELLITUS: A 3-YEAR FOLLOW-UP STUDY EXAMINING RISK FACTORS FOR TYPE 2 DIABETES IN PATIENTS WITH PREDIABETES
    Taras I. Griadil, Mykhaylo V. Bychko, Mykhaylo M. Hechko, Ksenia I. Chubirko, Ivan V. Chopey
    Polski Merkuriusz Lekarski.2023; 51(3): 245.     CrossRef
  • GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity
    Heegu Jin, Hyun-Ji Oh, Boo-Yong Lee
    Cells.2023; 12(17): 2146.     CrossRef
  • Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan
    Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards, Bradley T. Elliott
    Antioxidants.2023; 12(9): 1749.     CrossRef
  • Hyperinsulinemia Impairs Clathrin-Mediated Endocytosis of the Insulin Receptor and Activation of Endothelial Nitric Oxide Synthase in Brain Endothelial Cells
    Stephanie G. DiLucia, B. Jacob Kendrick, Catrina Sims-Robinson
    International Journal of Molecular Sciences.2023; 24(19): 14670.     CrossRef
  • Flavonoids from Lophatherum gracile Brongn. Ameliorate Liver Damages in High-Fat Diet and Streptozotocin-Induced Diabetic Mice by Regulating PI3K/AKT and NF-Kappa B Pathways
    Jian-Hua Zheng, Song-Xia Lin, Xiao-Yi Li, Chun-Yan Shen, Shao-Wei Zheng, Wen-Bin Chen, Walid Elfalleh
    Journal of Food Biochemistry.2023; 2023: 1.     CrossRef
  • Asprosin, a novel glucogenic adipokine implicated in type 2 diabetes mellitus
    Hongcui Diao, Xue Li, Yeqiu Xu, Xiuli Xing, Shuguang Pang
    Journal of Diabetes and its Complications.2023; 37(11): 108614.     CrossRef
  • Impact of Fixed Combination of Metformin and Pioglitazone on Insulin Resistance of Patients with Type 2 Diabetes: Results of a Randomized Open-Label Study
    Rui Sun, Lu Yuan, Yun Shen, Ziyang Shen, Bo Ding, Jianhua Ma
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2911.     CrossRef
  • Integrating network analysis and experimental validation to reveal the mechanism of pinocembrin in alleviating high glucose and free fatty acid-induced lipid accumulation in HepG2 cells
    Kun Hu, Yongjin Sun, Jie Wang, Shaojun Wu, Jie Ren, Dan Su, Lidan Tang, Jinhong Gong, Hufeng Fang, Shan Xu, Hao Yang
    Journal of Functional Foods.2023; 110: 105879.     CrossRef
  • A Literature Review and a Proposed Classification of the Relationships between Ovulatory Infertility and Lifestyle Factors Based on the Three Groups of Ovulation Disorders Classified by WHO
    Magdalena Skowrońska, Michał Pawłowski, Robert Milewski
    Journal of Clinical Medicine.2023; 12(19): 6275.     CrossRef
  • Targeting of insulin receptor endocytosis as a treatment to insulin resistance
    Bryce Tim, Valentina L. Kouznetsova, Santosh Kesari, Igor F. Tsigelny
    Journal of Diabetes and its Complications.2023; 37(11): 108615.     CrossRef
  • A U-shaped association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of incident type 2 diabetes mellitus in Japanese men with normal glycemic levels: a population-based longitudinal cohort study
    Bei Song, Kun Wang, Weilin Lu, Xiaofang Zhao, Tianci Yao, Ting Liu, Guangyu Gao, Haohui Fan, Chengyun Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study
    Yan Zeng, Li Yin, Xiaoping Yin, Danqing Zhao
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The protective role of resveratrol in diabetic wound healing
    Minglei Bi, Yonghong Qin, Lerong Wang, Jin Zhang
    Phytotherapy Research.2023; 37(11): 5193.     CrossRef
  • Correlation between alternative insulin resistance indexes and diabetic kidney disease: a retrospective study
    Xiaodie Mu, Aihua Wu, Huiyue Hu, Min Yang, Hua Zhou
    Endocrine.2023; 84(1): 136.     CrossRef
  • Enhancing Muscle Intracellular Ca2+ Homeostasis and Glucose Uptake: Passive Pulsatile Shear Stress Treatment in Type 2 Diabetes
    Arkady Uryash, Jordan Umlas, Alfredo Mijares, Jose A. Adams, Jose R. Lopez
    Biomedicines.2023; 11(10): 2596.     CrossRef
  • Review of Related Research on Type 2 Diabetes Related Macroangiopathy
    珊珊 李
    Advances in Clinical Medicine.2023; 13(09): 15001.     CrossRef
  • Association between lipoprotein(a) and insulin resistance in Chinese adults: results from the China health and nutrition survey
    Heng Wang, Jia-Li Fan
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association between the Triglyceride–Glucose Index and Non-Alcoholic Fatty Liver Disease in patients with Atrial Fibrillation
    Xiaozhong Li, Fenfang Zhan, Tian Peng, Zhen Xia, Juxiang Li
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • Resveratrol as a potential protective compound against skeletal muscle insulin resistance
    Arash Bahramzadeh, Kosar Bolandnazar, Reza Meshkani
    Heliyon.2023; 9(11): e21305.     CrossRef
  • The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging
    Zheng Ding, Yuqiu Wei, Jing Peng, Siyu Wang, Guixi Chen, Jiazeng Sun
    Biomedicines.2023; 11(10): 2711.     CrossRef
  • Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?
    Abdelaziz Ghanemi, Fabrice Mac-Way
    Life.2023; 13(11): 2172.     CrossRef
  • Correlation of Lipid Profile and Apolipoprotein B/A-I Ratio with Insulin Resistance in Non-Diabetes Mellitus Subjects
    Andi Heriadi Palloge, Liong Boy Kurniawan, Yuyun Widyaningsih, Husaini Umar, Nurahmi Nurahmi, Andi Alfian Zainuddin
    INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY.2023; 30(1): 6.     CrossRef
  • Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications
    Josefa Benítez-Camacho, Antonio Ballesteros, Lucía Beltrán-Camacho, Marta Rojas-Torres, Antonio Rosal-Vela, Margarita Jimenez-Palomares, Ismael Sanchez-Gomar, Mª Carmen Durán-Ruiz
    Stem Cell Research & Therapy.2023;[Epub]     CrossRef
  • Effects of ginseng peptides on the hypoglycemic activity and gut microbiota of a type 2 diabetes mellitus mice model
    Caijing Han, Xiaoting Kong, Xiaohong Xia, Xinyu Huang, Zhaojie Mao, Jiaxin Han, Fuyan Shi, Yaohui Liang, Anning Wang, Fengxiang Zhang
    Journal of Functional Foods.2023; 111: 105897.     CrossRef
  • Effects of theasaponin E1 on the regulationglucose uptake of C2C12 myoblasts PI3K/Akt/mTOR signaling pathway
    Ming Zhang, Zhiyun Chen, Di Tian, Zaiqiao Li, Shaning Wang, Yujie Huo, Ling Song, Juan Lu, Jun Sheng, Xu Ji, Xiao Ma
    CyTA - Journal of Food.2023; 21(1): 682.     CrossRef
  • Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review
    Yajie Cai, Qiaoning Yang, Yanqiao Yu, Furong Yang, Ruina Bai, Xiaodi Fan
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Adipocyte-derived exosomal miR-22-3p modulated by circadian rhythm disruption regulates insulin sensitivity in skeletal muscle cells
    Haohao Zhang, Xiaoning Zhang, Saifei Wang, Lu Zheng, Hengru Guo, Yanqi Ren, Bo Qiao, Jing Wu, Di Zhao, Lijun Xu, Shengnan Ma, Xiao Hao, Yushan Yan
    Journal of Biological Chemistry.2023; 299(12): 105476.     CrossRef
  • Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo
    Leilei Ma, Xiaojin La, Biwei Zhang, Wenxuan Xu, Chunyu Tian, Qianru Fu, Meng Wang, Chenxi Wu, Zhen Chen, Hong Chang, Ji-an Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function
    Shiqi Lu, Zhen-Bo Cao
    Nutrients.2023; 15(22): 4832.     CrossRef
  • Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study
    Shiming He, Changhui Yu, Maobin Kuang, Jiajun Qiu, Ruijuan Yang, Shuhua Zhang, Guotai Sheng, Yang Zou
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The association between the metabolic score for insulin resistance (METS-IR) index and urinary incontinence in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2018
    Shangqi Cao, Linghao Meng, Lede Lin, Xu Hu, Xiang Li
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle
    Francisco A. Monsalve, Fernando Delgado-López, Barbra Fernández-Tapia, Daniel R. González
    International Journal of Molecular Sciences.2023; 24(24): 17168.     CrossRef
  • Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
    Guizheng Wei, Ke Lu, Muhammad Umar, Zhenglin Zhu, William W. Lu, John R. Speakman, Yan Chen, Liping Tong, Di Chen
    Bone Research.2023;[Epub]     CrossRef
  • Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers
    Miguel Mestre Font, Carla Busquets-Cortés, José Ignacio Ramírez-Manent, Pilar Tomás-Gil, Hernán Paublini, Ángel Arturo López-González
    Nutrients.2023; 15(24): 5122.     CrossRef
  • Konjac flour-mediated gut microbiota alleviates insulin resistance and improves placental angiogenesis of obese sows
    Deyuan Wu, Wenyu Xiong, Shuo Ma, Jinxi Luo, Hongxuan Ye, Shuangbo Huang, Fuyong Li, Xi’en Xiang, Qiling Chen, Binghui Gao, Jinping Deng, Yulong Yin, Chengquan Tan
    AMB Express.2023;[Epub]     CrossRef
  • Physiological Adaptations to Life in Space: An Update
    Isadora de Carvalho e Silva, Thais Russomano, Ricardo Alves Ferreira, Marli do Carmo Cupertino, Fabíola Alves Alcântara, Mauro Geller, Oswaldo Monteiro Del Cima, Rodrigo Siqueira-Batista
    Journal of Aerospace Technology and Management.2023;[Epub]     CrossRef
  • Blood and Brain Metabolites after Cerebral Ischemia
    Eva Baranovicova, Dagmar Kalenska, Peter Kaplan, Maria Kovalska, Zuzana Tatarkova, Jan Lehotsky
    International Journal of Molecular Sciences.2023; 24(24): 17302.     CrossRef
  • Key Therapeutic Targets to Treat Hyperglycemia-Induced Atherosclerosis Analyzed Using a Petri Net-Based Model
    Agnieszka Rybarczyk, Dorota Formanowicz, Piotr Formanowicz
    Metabolites.2023; 13(12): 1191.     CrossRef
  • Exploration of the Mechanism of the Comorbidity Relationship between Alzheimer’s Disease and Diabetes Mellitus
    涛 温
    Medical Diagnosis.2023; 13(04): 440.     CrossRef
  • Postbiyotikler ve İnsülin Direnci
    Betül SARIDAĞ DEVRAN, Mendane SAKA
    Van Sağlık Bilimleri Dergisi.2023; 16(3): 268.     CrossRef
  • The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies
    Tomasz Szkudelski, Katarzyna Szkudelska
    International Journal of Molecular Sciences.2023; 25(1): 431.     CrossRef
  • Clinical application of Momordica charantia (Bitter Melon) for reducing blood sugar in type 2 diabetes mellitus
    Ashley Dahlquist, Dana Jandali, Mirielle C. Nauman, Jeremy J. Johnson, Sasho Stoleski
    International Journal of Nutrition.2023; 7(4): 8.     CrossRef
  • Alkaloids as Promising Agents for the Management of Insulin Resistance: A Review
    Ayoub Amssayef, Mohamed Eddouks
    Current Pharmaceutical Design.2023; 29(39): 3123.     CrossRef
  • A Brief Review of Commonly Used Indices for the Assessment of Insulin Sensitivity and Resistance
    Mudhafar S. Khazaal, Rawaa Hamid Abdulshahed, Alaa Khalid Ali Alabbas
    Academic International Journal of Medical Update.2023; 1(2): 01.     CrossRef
  • Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance
    Sindre Lee-Ødegård, Thomas Olsen, Frode Norheim, Christian Andre Drevon, Kåre Inge Birkeland
    Metabolites.2022; 12(3): 208.     CrossRef
  • Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas
    Jordan A. Higgs, Alyssa P. Quinn, Kevin D. Seely, Zeke Richards, Shad P. Mortensen, Cody S. Crandall, Amanda E. Brooks
    International Journal of Molecular Sciences.2022; 23(8): 4340.     CrossRef
  • The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults
    Desiree M. Sigala, Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle V. Nunez, Andrew A. Bremer, Chad L. Cox, Candice A. Price, Yanet Benyam, Yasser Abdelhafez, John P. McGahan, Nancy L. Keim, Michael I. Goran, Giovanni Pacini, Andrea Tura, Clau
    Nutrients.2022; 14(8): 1648.     CrossRef
  • Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism
    Mengyi Guo, Jiaokun Jia, Jia Zhang, Mingyue Zhou, Anxin Wang, Shengyun Chen, Xingquan Zhao
    BMC Neurology.2022;[Epub]     CrossRef
  • The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications
    Rossella Palma, Annamaria Pronio, Mario Romeo, Flavia Scognamiglio, Lorenzo Ventriglia, Vittorio Maria Ormando, Antonietta Lamazza, Stefano Pontone, Alessandro Federico, Marcello Dallio
    Journal of Clinical Medicine.2022; 11(13): 3649.     CrossRef
  • Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
    Kah Kheng Goh, Cynthia Yi-An Chen, Tzu-Hua Wu, Chun-Hsin Chen, Mong-Liang Lu
    International Journal of Molecular Sciences.2022; 23(13): 7092.     CrossRef
  • TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients
    Jianqi Zhao, Hongxuan Fan, Ting Wang, Bing Yu, Shaobin Mao, Xun Wang, Wenjing Zhang, Leigang Wang, Yao Zhang, Zhaoyu Ren, Bin Liang
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D
    Tammy Speelman, Lieke Dale, Ann Louw, Nicolette J. D. Verhoog
    Cells.2022; 11(14): 2163.     CrossRef
  • Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review
    Maša Pintarič, Tomaž Langerholc
    Life.2022; 12(8): 1187.     CrossRef
  • Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review
    Ángel Fernández-Aparicio, María Correa-Rodríguez, Jose M. Castellano, Jacqueline Schmidt-RioValle, Javier S. Perona, Emilio González-Jiménez
    Antioxidants.2022; 11(8): 1517.     CrossRef
  • Impact of Highly Saturated versus Unsaturated Fat Intake on Carbohydrate Metabolism and Vascular Reactivity in Rat
    Youzan Ferdinand Djohan, Fabrice Raynaud, Karen Lambert, Jean-Paul Cristol, Charles Coudray, Christine Feillet-Coudray, Anne Virsolvy, Eric Badia, Néstor Gutiérrez-Méndez
    Biochemistry Research International.2022; 2022: 1.     CrossRef
  • Mitophagy: A potential therapeutic target for insulin resistance
    Peng Ning, Xiaobo Jiang, Jing Yang, Jiaxing Zhang, Fan Yang, Hongyi Cao
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Higher neutrophil to lymphocyte ratio is associated with renal dysfunction and cardiac adverse remodeling in elderly with metabolic syndrome
    Yuqi Zhu, Gang Li, Jari A. Laukkanen, Xing Song, Jing Zhang, Linping Wei, Xinrui Chen, Yufeng Li, Cheng Liu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Lipid droplet accumulation in β cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and β cell dysfunction involving decreased insulin granules
    Tomomi Horii, Junji Kozawa, Yukari Fujita, Satoshi Kawata, Harutoshi Ozawa, Chisaki Ishibashi, Sho Yoneda, Takao Nammo, Jun-ichiro Miyagawa, Hidetoshi Eguchi, Iichiro Shimomura
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Comparing the long non-coding RNA expression profiles of skeletal muscle and kidney tissues from patients with diabetes
    Young-Kook Kim, Takahiro Nemoto
    PLOS ONE.2022; 17(9): e0274794.     CrossRef
  • The CCR2+ Monocyte Subsets Increase in Obese Boys but Not Girls with Abnormally High Carotid Intima-Media Thickness: A Pilot Study
    María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos López-Alv
    Journal of Cardiovascular Development and Disease.2022; 9(10): 330.     CrossRef
  • Effect of honey bee venom on the histological changes of testes and hormonal disturbance in diabetic mice
    Sattar J. J. AL-Shaeli, Talal Jabal Hussen, Ali M. Ethaeb
    Veterinary World.2022; : 2357.     CrossRef
  • Establishment and Validation of a New Predictive Model for Insulin Resistance based on 2 Chinese Cohorts: A Cross-Sectional Study
    Shi Zhang, Xin-Cheng Wang, Jing Li, Xiao-He Wang, Yi Wang, Yan-Ju Zhang, Mei-Yang Du, Min-Ying Zhang, Jing-Na Lin, Chun-Jun Li, Aman Rajpal
    International Journal of Endocrinology.2022; 2022: 1.     CrossRef
  • Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver
    You Wu, Boju Sun, Xiaoyuan Guo, Lili Wu, Yaomu Hu, Lingling Qin, Tao Yang, Mei Li, Tianyu Qin, Miao Jiang, Tonghua Liu
    Chinese Medicine.2022;[Epub]     CrossRef
  • Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin-Resistant Participants
    Lana Alghanem, Xiangmin Zhang, Ruchi Jaiswal, Berhane Seyoum, Abdullah Mallisho, Zaher Msallaty, Zhengping Yi
    ACS Omega.2022; 7(47): 42763.     CrossRef
  • Dietary Plant Protein Intake Can Reduce Maternal Insulin Resistance during Pregnancy
    Yuting Hong, Chen Yang, Jinjing Zhong, Yanmei Hou, Kui Xie, Linlin Wang
    Nutrients.2022; 14(23): 5039.     CrossRef
  • Preventive effect of probiotics supplementation on occurrence of gestational diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
    Azin Pakmehr, Hanieh-Sadat Ejtahed, Nooshin Shirzad, Mahboobeh Hemmatabadi, Sara Farhat, Bagher Larijani
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
    Peng-Fei Ding, Hua-Sheng Zhang, Jie Wang, Yong-Yue Gao, Jian-Nan Mao, Chun-Hua Hang, Wei Li
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
    Weili Yang, Yixiang Lyu, Rui Xiang, Jichun Yang
    International Journal of Molecular Sciences.2022; 23(24): 16054.     CrossRef
  • Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values
    Yanbei Duo, Shuoning Song, Yuemei Zhang, Xiaolin Qiao, Jiyu Xu, Jing Zhang, Zhenyao Peng, Yan Chen, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Ailing Wang, Wei Sun, Yong Fu, Yingyue Dong, Zechun Lu, Tao Yuan, Weigang Zhao
    Journal of Personalized Medicine.2022; 13(1): 60.     CrossRef
  • MODERN CONCEPTS OF THE PATHOGENESIS OF TYPE 2 DIABETES MELLITUS
    D.V. Kurkin, E.I. Morkovin, D.A. Bakulin, Yu.V. Gorbunova, A.V. Strygin, A.I. Robertus, I.E. Makarenko, V.B. Saparova, R.V. Drai, V.I. Petrov
    Journal of Volgograd State Medical University.2022; 19(4): 34.     CrossRef
Metabolic risk/Epidemiology
Article image
Obesity, Diabetes, and Increased Cancer Progression
Dae-Seok Kim, Philipp E. Scherer
Diabetes Metab J. 2021;45(6):799-812.   Published online November 22, 2021
DOI: https://doi.org/10.4093/dmj.2021.0077
  • 17,634 View
  • 789 Download
  • 108 Web of Science
  • 111 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including liver, pancreatic, endometrial, colorectal, and post-menopausal breast cancer. The path towards developing obesity and diabetes is affected by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, and hyperlipidemia. The metabolic abnormalities associated with changes in the levels of these factors in obesity and diabetes have the potential to significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways. Here, we highlight the cellular and molecular pathways that constitute the links between obesity, diabetes, cancer risk and mortality. This includes a description of the existing evidence supporting the obesity-driven morphological and functional alternations of cancer cells and adipocytes through complex interactions within the tumor microenvironment.

Citations

Citations to this article as recorded by  
  • Effects of T2DM on postoperative outcome of patients with colorectal cancer: a study on the relationship between blood glucose control and survival rate
    Kangzhong Wu
    American Journal of Cancer Research.2024; 14(4): 1892.     CrossRef
  • Triglyceride‐glucose index (TyG index) and endometrial carcinoma risk: A retrospective cohort study
    Haimeng Shi, Feifei Guo, Kang Zheng, Rong Li, Huaijun Zhou
    International Journal of Gynecology & Obstetrics.2024; 164(1): 298.     CrossRef
  • Association between total cholesterol levels and all-cause mortality among newly diagnosed patients with cancer
    Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • The Role of Adipokines in Tumor Progression and Its Association with Obesity
    Jae Won Kim, Jun Hyeok Kim, Yoon Jae Lee
    Biomedicines.2024; 12(1): 97.     CrossRef
  • Triglyceride-glucose index is a risk factor for breast cancer in China: a cross-sectional study
    Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Insulin Resistance: The Increased Risk of Cancers
    Leszek Szablewski
    Current Oncology.2024; 31(2): 998.     CrossRef
  • Epigenetic modifications in obesity‐associated diseases
    Yiqian Long, Chao Mao, Shuang Liu, Yongguang Tao, Desheng Xiao
    MedComm.2024;[Epub]     CrossRef
  • The Juncture of Diabetes, Cancer, and Observational Population-based Studies: Novel Insights From Canadian Provincial Health Records
    Terra Arnason, Kerry Mansell
    Canadian Journal of Diabetes.2024; 48(3): 145.     CrossRef
  • The impact of chemotherapy on adipose tissue remodeling: The molecular players involved in this tissue wasting
    Samuel Barbosa, Mafalda Barbosa Pedrosa, Rita Ferreira, Daniel Moreira-Gonçalves, Lúcio Lara Santos
    Biochimie.2024; 223: 1.     CrossRef
  • Epidemiological and transcriptome data identify shared gene signatures and immune cell infiltration in type 2 diabetes and non-small cell lung cancer
    Qian Yuan, Long Li, Liu-shun Wang, Shi-gui Xing
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • THE INFLUENCE OF DIABETES-ASSOCIATED FACTORS OF ONCOGENESIS ON THE RISK OF BREAST AND ENDOMETRIAL CANCER AND ON THE SURVIVAL OF WOMEN WITH THIS CANCER
    Tamara S. Vatseba, Liubov K. Sokolova, Vasyl Ye. Neyko, Valentyna V. Dzvonkovska, Oksana V. Muravlova, Volodymyr V. Derpak
    Clinical and Preventive Medicine.2024; (2): 99.     CrossRef
  • Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
    Heléna Safadi, Ágnes Balogh, Judit Lám, Attila Nagy, Éva Belicza
    Diabetes Research and Clinical Practice.2024; 211: 111665.     CrossRef
  • Colorectal Cancer: Epidemiology, Risk Factors, and Prevention
    Gholamreza Roshandel, Fatemeh Ghasemi-Kebria, Reza Malekzadeh
    Cancers.2024; 16(8): 1530.     CrossRef
  • Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer
    Antonino Colloca, Isabella Donisi, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D’Onofrio
    Cells.2024; 13(8): 663.     CrossRef
  • Changes in physical activity and diabetes risk after cancer diagnosis: a nationwide cohort study
    Wonyoung Jung, In Young Cho, Jinhyung Jung, Mi Hee Cho, Hye Yeon Koo, Yong-Moon Mark Park, Jong-Ha Baek, Kyungdo Han, Dong Wook Shin
    Journal of Cancer Survivorship.2024;[Epub]     CrossRef
  • Stratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes
    Dongjuan Chen, Zilu Xie, Jun Yang, Ting Zhang, Qiliang Xiong, Chen Yi, Shaofeng Jiang
    Discover Oncology.2024;[Epub]     CrossRef
  • Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation
    Annadurai Vinothkanna, Xiang Shi‐Liang, Durairaj Karthick Rajan, Ragothaman Prathiviraj, Soundarapandian Sekar, Shubing Zhang, Bo Wang, Zhu Liu, Ai‐Qun Jia
    Food Frontiers.2024; 5(4): 1476.     CrossRef
  • Glycometabolism and lipid metabolism related genes predict the prognosis of endometrial carcinoma and their effects on tumor cells
    Xuefen Lin, Jianfeng Zheng, Xintong Cai, Li Liu, Shan Jiang, Qinying Liu, Yang Sun
    BMC Cancer.2024;[Epub]     CrossRef
  • Diabetes and Cancer: A Twisted Bond
    Mihai Cosmin Stan, Doru Paul
    Oncology Reviews.2024;[Epub]     CrossRef
  • The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
    Shahad Sabaawi Ibrahim, Raghad Sabaawi Ibrahim, Batoul Arabi, Aranka Brockmueller, Mehdi Shakibaei, Dietrich Büsselberg
    Cancer and Metastasis Reviews.2024;[Epub]     CrossRef
  • Association of systemic inflammation markers in cancer mortality with diabetes: evidence from National Health and Nutrition Examination Survey
    Wenjie Li, Peixin Dong, Wei Wang
    Acta Diabetologica.2024; 61(11): 1403.     CrossRef
  • A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
    He-Zhou Guo, Rui-Xue Feng, Yan-Jie Zhang, Ye-Hua Yu, Wei Lu, Jia-Jia Liu, Shao-Xin Yang, Chong Zhao, Zhao-Li Zhang, Shan-He Yu, Hui Jin, Si-Xuan Qian, Jian-Yong Li, Jiang Zhu, Jun Shi
    Cell Reports Medicine.2024; 5(6): 101592.     CrossRef
  • Targeting SIRT3 signaling alleviates lung carcinoma progression by reducing hyperinsulinemia in postmenopausal obese mice: Protective intervention of betaxanthin
    Bobo Li, Jie Liu, Yuhui Sun, Mengmeng Song, Xiaoming Zhao, Yulan Sun
    Journal of Functional Foods.2024; 119: 106313.     CrossRef
  • Global prevalence of obesity and overweight among medical students: a systematic review and meta-analysis
    Arman Shafiee, Zahra Nakhaee, Razman Arabzadeh Bahri, Mohammad Javad Amini, Amirhossein Salehi, Kyana Jafarabady, Niloofar Seighali, Pegah Rashidian, Hanieh Fathi, Fatemeh Esmaeilpur Abianeh, Samira Parvizi Omran, Mahmood Bakhtiyari, Amirhesam Alirezaei
    BMC Public Health.2024;[Epub]     CrossRef
  • Association of body composition indicators with colorectal cancer: a hospital-based case-control study
    Qiujin Chen, Kai Li, Yang Liu, Xiaozhai Yu, Fengrong Ou
    Journal of Cancer Research and Clinical Oncology.2024;[Epub]     CrossRef
  • CD161 + CD127 + CD8 + T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus
    Jingjing Qu, Yuekang Li, Binggen Wu, Qian Shen, Lijun Chen, Wenjia Sun, Bo Wang, Lixiong Ying, Li Wu, Hong Zhou, Jianya Zhou, Jianying Zhou
    OncoImmunology.2024;[Epub]     CrossRef
  • The dichloromethane fraction from Calotropis gigantea (L.) dryand. Stem bark extract prevents liver cancer in SDT rats with insulin-independent diabetes mellitus
    Thaiyawat Haewphet, Supawadee Parhira, Pattaraporn Chaisupasakul, Apirath Wangteeraprasert, Ittipon Phoungpetchara, Dumrongsak Pekthong, Worasak Kaewkong, Zhi-Hong Jiang, Li-Ping Bai, Julintorn Somran, Piyarat Srisawang
    Journal of Ethnopharmacology.2024; 334: 118516.     CrossRef
  • Associations between Diabetes Mellitus and Selected Cancers
    Monika Pliszka, Leszek Szablewski
    International Journal of Molecular Sciences.2024; 25(13): 7476.     CrossRef
  • Combination of handgrip strength and high-sensitivity modified Glasgow prognostic score predicts survival outcomes in patients with colon cancer
    Yifan Shi, Yuting Sun, Xiaoming Shen, Zenghui Yang, Binghua Xu, Chuanqing Bao
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • DIABETES MELLITUS TIPO 2 E OBESIDADE, PRÓGONOS DE NEOPLASIAS?
    Victor Becchi, Luísa Emanoela Bandolin Goinski, Ana Letícia Loesch Wojcik, Patrícia Costa Mincoff Barbanti
    Revista Contemporânea.2024; 4(7): e5071.     CrossRef
  • Research Progress on the Association between Obesity and Prostate Cancer
    Hang Xu, Yingshuang Tang, Xiaorui Zhang, Xian Zhang, Along Kang
    annals of urologic oncology.2024;[Epub]     CrossRef
  • Associations Between Dietary Intake of Tomato and Lycopene with All-Cause and Cancer-Specific Mortality in US Adults with Diabetes: Results From a Cohort Study
    Yuqian Liu, Heyin Liu, Jinde Liu, Wen Liu, Yang Yang, Yiming Liu
    Nutrition and Cancer.2024; 76(10): 974.     CrossRef
  • Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer
    Chaojun Zhu, Yihong Lai, Chengdong Liu, Lan Teng, Yuxin Zhu, Xinyu Lin, Xinyi Fu, Qiuhua Lai, Side Liu, Xiaohan Zhou, Yuxin Fang
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Glycemic Burden and Clinical Outcomes of Early Stage Hepatocellular Carcinoma after Curative Treatment
    Hyun Joo Lee, Moon Seok Choi, Byeong Geun Song, Won Seok Kang, Geum Youn Gwak, Myung Ji Goh, Yong Han Paik, Joon Hyeok Lee, Dong Hyun Sinn
    Cancers.2024; 16(15): 2652.     CrossRef
  • The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside
    Xiaofei Shen, Hongling Yang, Yang Yang, Xianjun Zhu, Qingxiang Sun
    MedComm.2024;[Epub]     CrossRef
  • Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
    Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
    Diabetes & Metabolism Journal.2024; 48(4): 487.     CrossRef
  • Therapeutic advances of targeting receptor tyrosine kinases in cancer
    Ciprian Tomuleasa, Adrian-Bogdan Tigu, Raluca Munteanu, Cristian-Silviu Moldovan, David Kegyes, Anca Onaciu, Diana Gulei, Gabriel Ghiaur, Hermann Einsele, Carlo M. Croce
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
  • Clinical characteristics and complication risks in data‐driven clusters among Chinese community diabetes populations
    Binqi Li, Zizhong Yang, Yang Liu, Xin Zhou, Weiqing Wang, Zhengnan Gao, Li Yan, Guijun Qin, Xulei Tang, Qin Wan, Lulu Chen, Zuojie Luo, Guang Ning, Weijun Gu, Yiming Mu
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Optical imaging for brown or beige adipose tissue
    Jiamin Liu, Linjie Ni, Minmin Peng, Yiying Liang, Chan Lu, Hanying Zheng, Zicheng Huang, Jinde Zhang, Ronghe Chen
    VIEW.2024;[Epub]     CrossRef
  • Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis
    Zhou Liu, Longxuan Zheng
    Frontiers in Cardiovascular Medicine.2024;[Epub]     CrossRef
  • Evaluating coronary arteries and predicting MACEs using CCTA in lung cancer patients receiving chemotherapy or chemoradiotherapy
    Yuhang Xie, Hesong Shen, Qian Xu, Chunrong Tu, Rui Yang, Tao Liu, Hao Tang, Zhiming Miao, Jiuquan Zhang
    Radiotherapy and Oncology.2024; 200: 110498.     CrossRef
  • Risk factor analysis and nomogram development for predicting 28-day mortality in elderly ICU patients with sepsis and type 2 diabetes mellitus
    Haopeng Li, Yaru Zu, Qinghua Wang, Tong Zi, Xin Qin, Yan Zhao, Wei Jiang, Xin’an Wang, Chengdang Xu, Xi Chen, Gang Wu
    European Journal of Inflammation.2024;[Epub]     CrossRef
  • Analysis of the relationship between resistin with prognosis, cell migration, and p38 and ERK1/2 activation in breast cancer
    Reyna L. Cuachirria-Espinoza, Alin García-Miranda, Rafael Hernández-Barragán, Dania A. Nava-Tapia, Monserrat Olea-Flores, Napoleón Navarro-Tito
    Biochimie.2024;[Epub]     CrossRef
  • Relationship of body mass index and kidney outcomes in patients with primary glomerulonephritis: A systematic review and meta-analysis
    Qinling Liu, Tianhua Yao, Yan Chen, Fei Xiao, Yazhou Wu, Huanzi Dai
    Medicine.2024; 103(41): e39621.     CrossRef
  • The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer
    Wenzhe Li, Da Ke, Yi Xu, Ya Wang, Qian Wang, Jie Tan, Hongyan Wu, Xianglin Cheng
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Research status of anti-obesogenic functional foods: mechanism of endocrine-disrupting chemicals and glucocorticoid receptor pathway
    Ji-Hyun Im, Geon Oh, Xiaolu Fu, June Seok Lim, Sun-Il Choi, Ok-Hwan Lee
    Food Science and Biotechnology.2024;[Epub]     CrossRef
  • Histologic Characterization of Tumor-Adjacent Mammary Adipose Tissue in Normal-Weight and Overweight/Obese Patients with Triple-Negative Breast Cancer
    Marietta Wolf, Christoph Brochhausen, Vignesh Ramakrishnan, Sabine Iberl, Jonas Roth, Stephan Seitz, Ralph Burkhardt, Sonja C. Stadler
    Cancers.2024; 16(20): 3515.     CrossRef
  • Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells
    Maria Rosaria Ambrosio, Michiel Adriaens, Kasper Derks, Teresa Migliaccio, Valerio Costa, Domenico Liguoro, Simona Cataldi, Vittoria D’Esposito, Giovanni Maneli, Rita Bassolino, Simone Di Paola, Marinella Pirozzi, Fabrizio Schonauer, Francesco D’Andrea, F
    Scientific Reports.2024;[Epub]     CrossRef
  • Research Progress of Sodium-Glucose Co-Transporter Protein-2 Inhibitors in Lung Cancer
    晓倩 林
    Advances in Clinical Medicine.2024; 14(10): 1375.     CrossRef
  • Ultra‐processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Guo‐Chao Zhong, Qian Zhu, Dong Cai, Jie‐Jun Hu, Xin Dai, Jian‐Ping Gong, Wei‐Ping Sun
    International Journal of Cancer.2023; 152(5): 835.     CrossRef
  • Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay
    Cristina Pagano, Erika di Zazzo, Giorgio Avilia, Beatrice Savarese, Giovanna Navarra, Maria Chiara Proto, Donatella Fiore, Monica Rienzo, Patrizia Gazzerro, Chiara Laezza, Maurizio Bifulco
    International Journal of Cancer.2023; 152(12): 2464.     CrossRef
  • Metabolites as signalling molecules
    Steven Andrew Baker, Jared Rutter
    Nature Reviews Molecular Cell Biology.2023; 24(5): 355.     CrossRef
  • Characterization of neuroendocrine regulation- and metabolism-associated molecular features and prognostic indicators with aid to clinical chemotherapy and immunotherapy of patients with pancreatic cancer
    Biao Zhang, Qihang Yuan, Bolin Zhang, Shuang Li, Zhizhou Wang, Hangyu Liu, Fanyue Meng, Xu Chen, Dong Shang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Concentration of Selected Adipokines and Factors Regulating Carbohydrate Metabolism in Patients with Head and Neck Cancer in Respect to Their Body Mass Index
    Jarosław Nuszkiewicz, Jolanta Czuczejko, Wiktor Dróżdż, Alina Woźniak, Bogdan Małkowski, Karolina Szewczyk-Golec
    International Journal of Molecular Sciences.2023; 24(4): 3283.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • A novel five-gene metabolism-related risk signature for predicting prognosis and immune infiltration in endometrial cancer: A TCGA data mining
    Huaqing Huang, Xintong Cai, Jiexiang Lin, Qiaoling Wu, Kailin Zhang, Yibin Lin, Bin Liu, Jie Lin
    Computers in Biology and Medicine.2023; 155: 106632.     CrossRef
  • Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
    Ines D. Teixeira, Eugenia Carvalho, Ermelindo C. Leal
    Antibiotics.2023; 12(3): 467.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Relationship Between Physical Exercise and Cognitive Impairment Among Older Adults with Type 2 Diabetes: Chain Mediating Roles of Sleep Quality and Depression
    Han Zhang, Yefan Zhang, Sen Sheng, Yang Xing, Zhongchen Mou, Yanqiu Zhang, Zhixue Shi, Zhenjie Yu, Qianqian Gao, Weiqin Cai, Qi Jing
    Psychology Research and Behavior Management.2023; Volume 16: 817.     CrossRef
  • The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer
    Rosa Divella, Graziella Marino, Stefania Infusino, Laura Lanotte, Gaia Gadaleta-Caldarola, Gennaro Gadaleta-Caldarola
    Nutrients.2023; 15(7): 1667.     CrossRef
  • Distribution of ABO blood groups and Rh factor in benign and malign thyroid nodules
    Muzaffer Serdar DENİZ
    Journal of Health Sciences and Medicine.2023; 6(2): 462.     CrossRef
  • The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer
    Sebastian Stępień, Paweł Olczyk, Joanna Gola, Katarzyna Komosińska-Vassev, Aleksandra Mielczarek-Palacz
    Cells.2023; 12(8): 1118.     CrossRef
  • Coronary Revascularization in Patients With Cancer
    Bala Pushparaji, Teodora Donisan, Dinu Valentin Balanescu, Jong Kun Park, Dominique J. Monlezun, Abdelrahman Ali, Ibrahim Halil Inanc, Jaime Caballero, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, Cezar Iliescu
    Current Treatment Options in Cardiovascular Medicine.2023; 25(6): 143.     CrossRef
  • Hepatocellular carcinoma in a large cohort of type 2 diabetes patients
    Carlo B. Giorda, Roberta Picariello, Barbara Tartaglino, Elisa Nada, Giuseppe Costa, Roberta Manti, Luca Monge, Roberto Gnavi
    Diabetes Research and Clinical Practice.2023; 200: 110684.     CrossRef
  • Prediction of Hypoglycemia in Diabetic Patients During Colonoscopy Preparation
    Xiaohua Lu, Lingqiao Xie, Wane Zhao, Chuangbiao Zhang, Xixi Luo, Yan Zhou
    Experimental and Clinical Endocrinology & Diabetes.2023; 131(05): 274.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin
    Mike R. Wilson, Shannon Harkins, Jake J. Reske, Rebecca A. Siwicki, Marie Adams, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
    Reproductive Biology and Endocrinology.2023;[Epub]     CrossRef
  • The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
    Byungyong Ahn
    International Journal of Molecular Sciences.2023; 24(10): 8811.     CrossRef
  • Mechanism of Cephalophyllum cephalus Intervention in Diabetes Based on Network Pharmacology and Molecular Docking Technology
    志梁 范
    Hans Journal of Medicinal Chemistry.2023; 11(02): 81.     CrossRef
  • Development and validation of a prognostic model based on metabolic risk score to predict overall survival of endometrial cancer in Chinese patients
    Xingchen Li, Xiao Yang, Yuan Cheng, Yangyang Dong, Jingyuan Wang, Jianliu Wang
    Journal of Gynecologic Oncology.2023;[Epub]     CrossRef
  • Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness
    Ting-Yu Chang, Kuo-Cheng Lan, Chia-Hung Wu, Meei-Ling Sheu, Rong-Sen Yang, Shing-Hwa Liu
    Archives of Toxicology.2023; 97(8): 2231.     CrossRef
  • The Link between Diabetes, Pancreatic Tumors, and miRNAs—New Players for Diagnosis and Therapy?
    Małgorzata Kozłowska, Agnieszka Śliwińska
    International Journal of Molecular Sciences.2023; 24(12): 10252.     CrossRef
  • Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions
    Leonardo de Andrade Mesquita, Laura Fink Wayerbacher, Gilberto Schwartsmann, Fernando Gerchman
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • Distinct Lipid Phenotype of Cancer-Associated Fibroblasts (CAFs) Isolated From Overweight/Obese Endometrial Cancer Patients as Assessed Using Raman Spectroscopy
    Tze Hua Yeu, Intan Sofia Omar, S.F. Abdul Sani, Dharini Pathmanathan, Boon Tong Goh, Nithyialakshmi Ravindran, Ik Hui Teo, Yogeeta Gunasagran, Noor Azmi Mat Adenan, Ivy Chung, Amira Hajirah Abd Jamil
    Applied Spectroscopy.2023; 77(7): 723.     CrossRef
  • Global, Regional, and National Epidemiology of Diabetes in Children From 1990 to 2019
    Kexin Zhang, Chengxia Kan, Fang Han, Jingwen Zhang, Chuanhua Ding, Zhentao Guo, Na Huang, Yang Zhang, Ningning Hou, Xiaodong Sun
    JAMA Pediatrics.2023; 177(8): 837.     CrossRef
  • The effects of physical exercise therapy on weight control: its regulation of adipocyte physiology and metabolic capacity
    Hyun Jung Park, Sung Ja Rhie, Insop Shim
    Journal of Exercise Rehabilitation.2023; 19(3): 141.     CrossRef
  • The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells
    Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elv
    Journal of Experimental & Clinical Cancer Research.2023;[Epub]     CrossRef
  • Signal detection in real‐world data and confirmation in clinical trials: Diabetes as a case study for a conversation worth having
    Elad Sharon, Megan Othus, Zoe Eloise Quandt
    Cancer.2023; 129(18): 2769.     CrossRef
  • Ultra-Processed Food Consumption and Obesity in Korean Adults
    Jee-Seon Shim, Kyoung Hwa Ha, Dae Jung Kim, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2023; 47(4): 547.     CrossRef
  • Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer
    Vanda Marques, Fabiola Arella, Marta B. Afonso, André A. Santos, Cecília M.P. Rodrigues
    Clinical Science.2023; 137(15): 1095.     CrossRef
  • Diabetes and two kinds of primary tumors in a patient with thalassemia: a case report and literature review
    Xiaoyan Yu, Yi Peng, Tingting Nie, Wenjia Sun, Yajuan Zhou
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study
    Eyun Song, Soon Young Hwang, Min Jeong Park, Ahreum Jang, Kyeong Jin Kim, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
    Metabolism.2023; 148: 155678.     CrossRef
  • Obesity and Colorectal Cancer
    Jundeok Lee, Su Young Kim
    The Korean Journal of Gastroenterology.2023; 82(2): 63.     CrossRef
  • Cognitive Behavioural Therapies for Weight-Loss in Adults: A Scoping Review Protocol
    Laura María Compañ-Gabucio, Diana Mancheño-Bañón, Laura Torres-Collado, Jesús Vioque, Manuela García-de-la-Hera
    Healthcare.2023; 11(18): 2473.     CrossRef
  • Saxagliptin, a selective dipeptidyl peptidase-4 inhibitor, alleviates somatic cell aneugenicity and clastogenicity in diabetic mice
    Sabry M. Attia, Sheikh F. Ahmad, Ahmed Nadeem, Mohamed S.M. Attia, Mushtaq A. Ansari, Abdelkader E. Ashour, Norah A. Albekairi, Mohammed A. Al-Hamamah, Ali A. Alshamrani, Saleh A. Bakheet
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis.2023; 892: 503707.     CrossRef
  • Mechanisms of Linggui Zhugan Decoction in the Treatment of Obesity Based on Network Pharmacology
    Chunmei Liu, Li Zhang, Yubin Yang
    Science of Advanced Materials.2023; 15(9): 1265.     CrossRef
  • Beyond Body Size: Adiponectin as a Key Player in Obesity-Driven Cancers
    Maurizio Capuozzo, Venere Celotto, Loris Landi, Francesco Ferrara, Francesco Sabbatino, Francesco Perri, Marco Cascella, Vincenza Granata, Mariachiara Santorsola, Alessandro Ottaiano
    Nutrition and Cancer.2023; 75(10): 1848.     CrossRef
  • Impact of sarcopenic obesity on post-hepatectomy bile leakage for hepatocellular carcinoma
    Hikaru Hayashi, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Hitoshi Masuo, Takahiro Yoshizawa, Kiyotaka Hosoda, Hiroki Sakai, Koya Yasukawa, Yuji Soejima, Ezio Lanza
    PLOS ONE.2023; 18(10): e0286353.     CrossRef
  • Colorectal Cancer: From Risk Factors to Oncogenesis
    Vlad Alexandru Ionescu, Gina Gheorghe, Nicolae Bacalbasa, Alexandru Laurentiu Chiotoroiu, Camelia Diaconu
    Medicina.2023; 59(9): 1646.     CrossRef
  • The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
    Barbara Mensah Sankofi, Estefania Valencia-Rincón, Malika Sekhri, Adriana L. Ponton-Almodovar, Jamie J. Bernard, Elizabeth A. Wellberg
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis
    Tingting Kong, Yunpeng Gu, Lei Sun, Run Zhou, Jie Li, Junping Shi
    Endocrine Journal.2023; 70(10): 959.     CrossRef
  • Impact of Caloric Restriction in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Prospective Case Control Study
    Isabella Castellano, Francesco Gallo, Paola Durelli, Taira Monge, Maurizio Fadda, Jasna Metovic, Paola Cassoni, Fulvio Borella, Carlo Raucci, Monica Menischetti, Alessandra Beano, Giuseppe Migliaretti, Concetta Finocchiaro
    Nutrients.2023; 15(21): 4677.     CrossRef
  • Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia
    Na Cui, Wensen Zhang, Fazhi Su, Zhihong Zhang, Biao Li, Donghui Peng, Yanping Sun, Yuanning Zeng, Bingyou Yang, Haixue Kuang, Qiuhong Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Is MG53 a potential therapeutic target for cancer?
    Yunyu Du, Tieying Li, Muqing Yi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Blood Biomarkers Panels for Screening of Colorectal Cancer and Adenoma on a Machine Learning-Assisted Detection Platform
    Hui Wang, Zhiwei Zhou, Haijun Li, Weiguang Xiang, Yilin Lan, Xiaowen Dou, Xiuming Zhang
    Cancer Control.2023;[Epub]     CrossRef
  • Post-treatment serum triglyceride: An effective biomarker for body fat mass and overall survival in esophageal squamous cell cancer patients treated with chemoradiotherapy
    Jiahua Lyu, Ningjing Yang, Wang Guan, Ling Xiao, Xinyu Nie, Long Liang, Hansong Bai, Churong Li, Hao Kuang, Xiao Wang, Tao Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Research Progress of MicroRNA-122 in Obesity and Type 2 Diabetes
    路路 潘
    Advances in Clinical Medicine.2022; 12(06): 5706.     CrossRef
  • Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022
    Ethan Lazarus, Harold Edward Bays
    Obesity Pillars.2022; 3: 100026.     CrossRef
  • Obesity Fact Sheet in Korea, 2021: Trends in Obesity Prevalence and Obesity-Related Comorbidity Incidence Stratified by Age from 2009 to 2019
    Ye Seul Yang, Byoung-Duck Han, Kyungdo Han, Jin-Hyung Jung, Jang Won Son
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 169.     CrossRef
  • Fried food consumption and the risk of pancreatic cancer: A large prospective multicenter study
    Guo-Chao Zhong, Qian Zhu, Jian-Ping Gong, Dong Cai, Jie-Jun Hu, Xin Dai, Jun-Hua Gong
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Intermittent Fasting Is Associated With a Decreased Risk of Age-Related Macular Degeneration
    Eun Young Choi, Min Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Minyoung Lee
    American Journal of Ophthalmology.2022; 243: 1.     CrossRef
  • Metformin Mitigated Obesity-Driven Cancer Aggressiveness in Tumor-Bearing Mice
    Chun-Jung Chen, Chih-Cheng Wu, Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Wen-Ying Chen, Su-Lan Liao, Jiaan-Der Wang
    International Journal of Molecular Sciences.2022; 23(16): 9134.     CrossRef
  • Visceral fat area and body fat percentage measured by bioelectrical impedance analysis correlate with glycometabolism
    Shuying Li, Shaoping Li, Jie Ding, Weihong Zhou
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer
    Roberto Buonaiuto, Fabiana Napolitano, Sara Parola, Pietro De Placido, Valeria Forestieri, Giovanna Pecoraro, Alberto Servetto, Luigi Formisano, Pietro Formisano, Mario Giuliano, Grazia Arpino, Sabino De Placido, Carmine De Angelis
    Biomolecules.2022; 12(10): 1394.     CrossRef
  • Adipokines as Regulators of Autophagy in Obesity-Linked Cancer
    Alin García-Miranda, Alejandra Garcia-Hernandez, Eduardo Castañeda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
    Cells.2022; 11(20): 3230.     CrossRef
  • Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
    Linyue Dong, Heyao Wang, Kaixian Chen, Yiming Li
    Biomedicine & Pharmacotherapy.2022; 156: 113981.     CrossRef
  • Changes in the Fecal Metabolome Accompany an Increase in Aberrant Crypt Foci in the Colon of C57BL/6 Mice Fed with a High-Fat Diet
    Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Andrew D. Magnuson, Matthew J. Picklo
    Biomedicines.2022; 10(11): 2891.     CrossRef
  • Targeting Adiponectin in Breast Cancer
    Rawan Nehme, Mona Diab-Assaf, Caroline Decombat, Laetitia Delort, Florence Caldefie-Chezet
    Biomedicines.2022; 10(11): 2958.     CrossRef
  • Multidisciplinary Progress in Obesity Research
    Xiaoqing Lu, Yuxin Jin, Dexin Li, Jingxin Zhang, Jingyan Han, Yin Li
    Genes.2022; 13(10): 1772.     CrossRef
  • The association between serum copper and obesity and all-cause mortality: the NHANES 2011–2016
    Hongrong Wu, Qingqi Li, Kaifang Zhang, Jianfeng Zhao
    Environmental Science and Pollution Research.2022; 30(11): 31395.     CrossRef
  • The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities
    Christina S. Ennis, Pablo Llevenes, Yuhan Qiu, Ruben Dries, Gerald V. Denis
    Frontiers in Endocrinology.2022;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP