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Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective
Junghyun Noh, Hyun-Ha Chang, In-Kyung Jeong, Kun Ho Yoon
Diabetes Metab J. 2020;44(3):372-381.   Published online June 29, 2020
DOI: https://doi.org/10.4093/dmj.2020.0138
  • 9,012 View
  • 144 Download
  • 11 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   

Diabetes has been associated with more severe outcomes and higher mortality in coronavirus disease 2019 (COVID-19) patients compare to morbidity and mortality in patients without diabetes. Several mechanisms may play a role in this greater morbidity and mortality, especially uncontrolled hyperglycemia, an impaired immune system, pre-existing proinflammatory states, multiple comorbidities, and dysregulated angiotensin-converting enzyme 2 signaling. Thus, the diabetes medical community emergently needs to know about COVID-19 and its effects on patients with diabetes, as they must take precautions to carefully manage these patients during the COVID-19 pandemic. The Korean Diabetes Association provides some guidance and practical recommendations for the management of diabetes during the pandemic. This report provides insight into the association between diabetes and COVID-19, proper management of diabetes in patients with COVID-19 and an official suggestion by the Korean Diabetes Association for managing the COVID-19 outbreak.

Citations

Citations to this article as recorded by  
  • Medical comorbidities as predictors of COVID-19 short-term mortality: A historical cohort study in Indonesia
    Rizaldy Taslim Pinzon, Vanessa Veronica
    Tzu Chi Medical Journal.2023; 35(1): 53.     CrossRef
  • A year of experience with COVID‐19 in patients with cancer: A nationwide study
    Mina Khosravifar, Sogol Koolaji, Negar Rezaei, Ali Ghanbari, Seyedeh Melika Hashemi, Erfan Ghasemi, Ali Bitaraf, Ozra Tabatabaei‐Malazy, Nazila Rezaei, Sahar Mohammadi Fateh, Arezou Dilmaghani‐Marand, Rosa Haghshenas, Ameneh Kazemi, Erfan Pakatchian, Farz
    Cancer Reports.2023;[Epub]     CrossRef
  • Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
    Yevgeniya Filippenko, Marianna Zagurovskaya, Aigul Abdrakhmanova, Saule Kassenova, Zhanar Zhakenova, Aizat Aimakhanova, Zhamilya Zholdybay
    Egyptian Journal of Radiology and Nuclear Medicine.2022;[Epub]     CrossRef
  • Being caught in the perfect storm of a diabetes epidemic and the COVID‐19 pandemic: What should we do for our patients?
    Yunjung Cho, Kun‐Ho Yoon
    Journal of Diabetes Investigation.2021; 12(3): 297.     CrossRef
  • COVID-19 associated with diabetes and other noncommunicable diseases led to a global health crisis
    Mark Thomaz Ugliara Barone, Belinda Ngongo, Simone Bega Harnik, Lucas Xavier de Oliveira, Dániel Végh, Patrícia Vieira de Luca, Hermelinda Cordeiro Pedrosa, Franco Giraudo, Roque Cardona-Hernandez, Nayanjeet Chaudhury, Luiz Menna-Barreto
    Diabetes Research and Clinical Practice.2021; 171: 108587.     CrossRef
  • Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
    Sang Chul Lee, Kang Ju Son, Chang Hoon Han, Seon Cheol Park, Ji Ye Jung
    Scientific Reports.2021;[Epub]     CrossRef
  • Effects of a DPP-4 Inhibitor and RAS Blockade on Clinical Outcomes of Patients with Diabetes and COVID-19
    Sang Youl Rhee, Jeongwoo Lee, Hyewon Nam, Dae-Sung Kyoung, Dong Wook Shin, Dae Jung Kim
    Diabetes & Metabolism Journal.2021; 45(2): 251.     CrossRef
  • Towards Telemedicine Adoption in Korea: 10 Practical Recommendations for Physicians
    Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Nutritional information access and dietary behavior among people with diabetes during Covid-19 pandemic
    Yovita Puri Subardjo, Gumintang Ratna Ramadhan, Dika Betaditya, Muflihatus Syarifah, Nurafifah Fauziana Abidin
    IOP Conference Series: Earth and Environmental Science.2021; 746(1): 012027.     CrossRef
  • Dissection of non-pharmaceutical interventions implemented by Iran, South Korea, and Turkey in the fight against COVID-19 pandemic
    Mohammad Keykhaei, Sogol Koolaji, Esmaeil Mohammadi, Reyhaneh Kalantar, Sahar Saeedi Moghaddam, Arya Aminorroaya, Shaghayegh Zokaei, Sina Azadnajafabad, Negar Rezaei, Erfan Ghasemi, Nazila Rezaei, Rosa Haghshenas, Yosef Farzi, Sina Rashedi, Bagher Larijan
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1919.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
  • Clinical Characteristics and Mortality Predictors of COVID-19 Patients Hospitalized at Nationally-Designated Treatment Hospitals
    Seong-Su Moon, Kwan Lee, Jungi Park, Seongcheol Yun, Yun Sik Lee, Dong Seok Lee
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Response: The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study (Diabetes Metab J 2020;44:405–13)
    Seung Min Chung, June Hong Ahn, Jun Sung Moon
    Diabetes & Metabolism Journal.2020; 44(4): 625.     CrossRef
  • Diabetes Mellitus and COVID-19
    Jeong Hyun Park
    The Journal of Korean Diabetes.2020; 21(3): 116.     CrossRef
Original Articles
Complications
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The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
Seung Min Chung, Yin Young Lee, Eunyeong Ha, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee, Jian Hur, Kyung Soo Hong, Jong Geol Jang, Hyun Jung Jin, Eun Young Choi, Kyeong-Cheol Shin, Jin Hong Chung, Kwan Ho Lee, June Hong Ahn, Jun Sung Moon
Diabetes Metab J. 2020;44(3):405-413.   Published online May 21, 2020
DOI: https://doi.org/10.4093/dmj.2020.0105
  • 11,269 View
  • 149 Download
  • 42 Web of Science
  • 50 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM.

Methods

This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group.

Results

After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045).

Conclusion

The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted.

Citations

Citations to this article as recorded by  
  • The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
    Hyeyeon Moon, Sunghwan Suh, Mi Kyoung Park
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Severity of Symptoms and Mortality in Diabetic Patients with COVID- 19 Infection. Review
    Zahraa ALBasry, Abeer Abdulhadi Rashid, Shaymaa Hasan Abbas
    Al Mustansiriyah Journal of Pharmaceutical Sciences.2023; 23(1): 91.     CrossRef
  • Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis
    Sabrina Schlesinger, Alexander Lang, Nikoletta Christodoulou, Philipp Linnerz, Kalliopi Pafili, Oliver Kuss, Christian Herder, Manuela Neuenschwander, Janett Barbaresko, Michael Roden
    Diabetologia.2023; 66(8): 1395.     CrossRef
  • COVID-19 and Cardiovascular Comorbidities
    Dirk Müller-Wieland, Nikolaus Marx, Michael Dreher, Katharina Fritzen, Oliver Schnell
    Experimental and Clinical Endocrinology & Diabetes.2022; 130(03): 178.     CrossRef
  • Prevalence and impact of diabetes in hospitalized COVID‐19 patients: A systematic review and meta‐analysis
    Sian A. Bradley, Maciej Banach, Negman Alvarado, Ivica Smokovski, Sonu M. M. Bhaskar
    Journal of Diabetes.2022; 14(2): 144.     CrossRef
  • Does metformin affect outcomes in COVID‐19 patients with new or pre‐existing diabetes mellitus? A systematic review and meta‐analysis
    Adithan Ganesh, Michael D. Randall
    British Journal of Clinical Pharmacology.2022; 88(6): 2642.     CrossRef
  • Cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocyte on hyperglycemic cardiomyocytes through alleviation of oxidative and endoplasmic reticulum stress
    Ceylan Verda Bitirim, Zeynep Busra Ozer, Dunya Aydos, Kardelen Genc, Seyma Demirsoy, Kamil Can Akcali, Belma Turan
    Scientific Reports.2022;[Epub]     CrossRef
  • Impact of diabetes on COVID‐19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta‐analysis
    Stavroula Kastora, Manisha Patel, Ben Carter, Mirela Delibegovic, Phyo Kyaw Myint
    Endocrinology, Diabetes & Metabolism.2022;[Epub]     CrossRef
  • Glycated Albumin and Glycated Albumin/HbA1c Predict the Progression of Coronavirus Disease 2019 from Mild to Severe Disease in Korean Patients with Type 2 Diabetes
    Jeongseon Yoo, Youngah Choi, Shin Ae Park, Ji Yeon Seo, Chul Woo Ahn, Jaehyun Han
    Journal of Clinical Medicine.2022; 11(9): 2327.     CrossRef
  • Novel Glycemic Index Based on Continuous Glucose Monitoring to Predict Poor Clinical Outcomes in Critically Ill Patients: A Pilot Study
    Eun Yeong Ha, Seung Min Chung, Il Rae Park, Yin Young Lee, Eun Young Choi, Jun Sung Moon
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Renin‐Angiotensin Aldosterone System Inhibitors and COVID‐19: A Systematic Review and Meta‐Analysis Revealing Critical Bias Across a Body of Observational Research
    Jordan Loader, Frances C. Taylor, Erik Lampa, Johan Sundström
    Journal of the American Heart Association.2022;[Epub]     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2022; 11: 729.     CrossRef
  • Evaluating the effect of COVID-19 on quality measures of patients with type 2 diabetes in two family nurse practitioner–owned clinics
    Wendy L. Wright, Patricia A. White, Meredith Welsh, Kelly Cutting
    Journal of the American Association of Nurse Practitioners.2022; 34(9): 1090.     CrossRef
  • Early glycaemic variability increases 28-day mortality and prolongs intensive care unit stay in critically ill patients with pneumonia
    Seong Ho Kim, Ji Young Kim, Eun Song Kim, Il Rae Park, Eun Yeong Ha, Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Annals of Medicine.2022; 54(1): 2724.     CrossRef
  • Anti-inflammatory drugs and the renin-angiotensin-aldosterone system: Current knowledge and potential effects on early SARS-CoV-2 infection
    Iris Louise N. Cabbab, Rafael Vincent M. Manalo
    Virus Research.2021; 291: 198190.     CrossRef
  • The Effect of Prior Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Treatment on Coronavirus Disease 2019 (COVID-19) Susceptibility and Outcome: A Systematic Review and Meta-analysis
    Jiuyang Xu, Yaqun Teng, Lianhan Shang, Xiaoying Gu, Guohui Fan, Yijun Chen, Ran Tian, Shuyang Zhang, Bin Cao
    Clinical Infectious Diseases.2021; 72(11): e901.     CrossRef
  • Diabetes predicts severity of COVID‐19 infection in a retrospective cohort: A mediatory role of the inflammatory biomarker C‐reactive protein
    Huilin Koh, Angela Mei Chung Moh, Ester Yeoh, Yi Lin, Serena Kiat Mun Low, Say Tat Ooi, Seng Kiong Tan, Jaime Hui Xian Lin, Caroline Wei Shan Hoong
    Journal of Medical Virology.2021; 93(5): 3023.     CrossRef
  • Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia
    Jesús Chávez-Reyes, Carlos E. Escárcega-González, Erika Chavira-Suárez, Angel León-Buitimea, Priscila Vázquez-León, José R. Morones-Ramírez, Carlos M. Villalón, Andrés Quintanar-Stephano, Bruno A. Marichal-Cancino
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis
    Giovanni Corona, Alessandro Pizzocaro, Walter Vena, Giulia Rastrelli, Federico Semeraro, Andrea M Isidori, Rosario Pivonello, Andrea Salonia, Alessandra Sforza, Mario Maggi
    Reviews in Endocrine and Metabolic Disorders.2021; 22(2): 275.     CrossRef
  • COVID-19 and diabetes: Analysis of the scientific production indexed in Scopus
    Ibraín Enrique Corrales-Reyes, Frank Hernández-García, Christian R. Mejia
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(3): 765.     CrossRef
  • Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
    Halla Kaminska, Lukasz Szarpak, Dariusz Kosior, Wojciech Wieczorek, Agnieszka Szarpak, Mahdi Al-Jeabory, Wladyslaw Gawel, Aleksandra Gasecka, Milosz J. Jaguszewski, Przemyslawa Jarosz-Chobot
    Acta Diabetologica.2021; 58(8): 1101.     CrossRef
  • Risk phenotypes of diabetes and association with COVID-19 severity and death: a living systematic review and meta-analysis
    Sabrina Schlesinger, Manuela Neuenschwander, Alexander Lang, Kalliopi Pafili, Oliver Kuss, Christian Herder, Michael Roden
    Diabetologia.2021; 64(7): 1480.     CrossRef
  • Evolution of a Cohort of COVID-19 Infection Suspects Followed-Up from Primary Health Care
    Valle Coronado-Vázquez, Maria del Valle Ramírez-Durán, Juan Gómez-Salgado, María Silvia Dorado-Rabaneda, Elena Benito-Alonso, Marina Holgado-Juan, Cristina Bronchalo-González
    Journal of Personalized Medicine.2021; 11(6): 459.     CrossRef
  • Efficacy and safety of dulaglutide 3.0 and 4.5 mg in patients aged younger than 65 and 65 years or older: Post hoc analysis of the AWARD‐11 trial
    Juan P. Frias, Enzo Bonora, Luis Nevárez Ruiz, Stanley H. Hsia, Heike Jung, Sohini Raha, David A. Cox, M. Angelyn Bethel, Manige Konig
    Diabetes, Obesity and Metabolism.2021; 23(10): 2279.     CrossRef
  • Renin‐Angiotensin Aldosterone System Inhibitors in Primary Prevention and COVID‐19
    Jordan Loader, Erik Lampa, Stefan Gustafsson, Thomas Cars, Johan Sundström
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Predictive value of HbA1c for in-hospital adverse prognosis in COVID-19: A systematic review and meta-analysis
    Zheng Zhu, Yaqian Mao, Gang Chen
    Primary Care Diabetes.2021; 15(6): 910.     CrossRef
  • High Fibrosis-4 Index Is Related with Worse Clinical Outcome in Patients with Coronavirus Disease 2019 and Diabetes Mellitus: A Multicenter Observational Study
    Sung-Woo Kim, Jae-Han Jeon, Jun Sung Moon, Mi Kyung Kim
    Endocrinology and Metabolism.2021; 36(4): 800.     CrossRef
  • COVID-19 Vaccination for Endocrine Patients: A Position Statement from the Korean Endocrine Society
    Cheol Ryong Ku, Kyong Yeun Jung, Chang Ho Ahn, Jun Sung Moon, Ju Hee Lee, Eun Heui Kim, Hyemi Kwon, Hee Kyung Kim, Sunghwan Suh, Sangmo Hong, Jeonghoon Ha, Eun Roh, Jin Hwa Kim, Mi-kyung Kim
    Endocrinology and Metabolism.2021; 36(4): 757.     CrossRef
  • A Systematic Review and Meta-analysis of Diabetes Associated Mortality in Patients with COVID-19
    Puneeta Gupta, Meeta Gupta, Neena KAtoch, Ketan Garg, Bhawna Garg
    International Journal of Endocrinology and Metabolism.2021;[Epub]     CrossRef
  • Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study
    Jennifer E. Nyland, Nazia T. Raja-Khan, Kerstin Bettermann, Philippe A. Haouzi, Douglas L. Leslie, Jennifer L. Kraschnewski, Leslie J. Parent, Patricia Sue Grigson
    Diabetes.2021; 70(12): 2903.     CrossRef
  • Impact of Diabetes on COVID-19 Mortality and Hospital Outcomes, a Global Perspective: An ONTOP Systematic Review and Meta-Analysis
    Stavroula Kastora, Manisha Patel, Ben Carter, Mirela Delibegovic, Phyo Kyaw Myint
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Response: Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports (Diabetes Metab J 2020;44:349–53)
    Na-young Kim, Eunyeong Ha, Jun Sung Moon, Yong-Hoon Lee, Eun Young Choi
    Diabetes & Metabolism Journal.2020; 44(3): 484.     CrossRef
  • Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis
    Luxiang Shang, Mengjiao Shao, Qilong Guo, Jia Shi, Yang Zhao, Jiasuoer Xiaokereti, Baopeng Tang
    Archives of Medical Research.2020; 51(7): 700.     CrossRef
  • Clinical Characteristics and Mortality Predictors of COVID-19 Patients Hospitalized at Nationally-Designated Treatment Hospitals
    Seong-Su Moon, Kwan Lee, Jungi Park, Seongcheol Yun, Yun Sik Lee, Dong Seok Lee
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes
    Dilaram Acharya, Kwan Lee, Dong Seok Lee, Yun Sik Lee, Seong-Su Moon
    Healthcare.2020; 8(3): 338.     CrossRef
  • Letter: The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study (Diabetes Metab J 2020;44:405–13)
    So-Yeon Kim, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2020; 44(4): 621.     CrossRef
  • Response: The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study (Diabetes Metab J 2020;44:405–13)
    Seung Min Chung, June Hong Ahn, Jun Sung Moon
    Diabetes & Metabolism Journal.2020; 44(4): 625.     CrossRef
  • The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea
    Mi Kyung Kim, Jae-Han Jeon, Sung-Woo Kim, Jun Sung Moon, Nan Hee Cho, Eugene Han, Ji Hong You, Ji Yeon Lee, Miri Hyun, Jae Seok Park, Yong Shik Kwon, Yeon-Kyung Choi, Ki Tae Kwon, Shin Yup Lee, Eon Ju Jeon, Jin-Woo Kim, Hyo-Lim Hong, Hyun Hee Kwon, Chi Yo
    Diabetes & Metabolism Journal.2020; 44(4): 602.     CrossRef
  • Fasting Plasma Glucose Level Independently Predicts the Mortality of Patients with Coronavirus Disease 2019 Infection: A Multicenter, Retrospective Cohort Study
    Min Cheol Chang, Jong-Moon Hwang, Jae-Han Jeon, Sang Gyu Kwak, Donghwi Park, Jun Sung Moon
    Endocrinology and Metabolism.2020; 35(3): 595.     CrossRef
  • Diabetes Mellitus and COVID-19
    Jeong Hyun Park
    The Journal of Korean Diabetes.2020; 21(3): 116.     CrossRef
  • Management of Diabetes in Coronavirus Disease 2019: Prognosis and Practical Issues
    Hye Soon Kim
    The Journal of Korean Diabetes.2020; 21(3): 120.     CrossRef
  • Independent Impact of Diabetes on the Severity of Coronavirus Disease 2019 in 5,307 Patients in South Korea: A Nationwide Cohort Study
    Sun Joon Moon, Eun-Jung Rhee, Jin-Hyung Jung, Kyung-Do Han, Sung-Rae Kim, Won-Young Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2020; 44(5): 737.     CrossRef
  • Adverse impact of renin–angiotensin system blockade on the clinical course in hospitalized patients with severe COVID-19: a retrospective cohort study
    Jeong-Hoon Lim, Jang-Hee Cho, Yena Jeon, Ji Hye Kim, Ga Young Lee, Soojee Jeon, Hee Won Noh, Yong-Hoon Lee, Jaehee Lee, Hyun-Ha Chang, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Shin-Woo Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective
    Junghyun Noh, Hyun-Ha Chang, In-Kyung Jeong, Kun Ho Yoon
    Diabetes & Metabolism Journal.2020; 44(3): 372.     CrossRef
  • Diabetes and COVID-19: Global and regional perspectives
    In-Kyung Jeong, Kun Ho Yoon, Moon Kyu Lee
    Diabetes Research and Clinical Practice.2020; 166: 108303.     CrossRef
Epidemiology
Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han
Diabetes Metab J. 2019;43(6):815-829.   Published online January 21, 2019
DOI: https://doi.org/10.4093/dmj.2018.0167
  • 5,724 View
  • 79 Download
  • 20 Web of Science
  • 19 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM).

Methods

From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 million, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslipidemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10.

Results

The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P<0.001). The group with T2DM (n=95) had higher incidence of CMV diseases than the group without T2DM (n=3,361) (33.7% vs. 16.2%, P<0.001). In multivariate regression model adjusted by age, sex, lower income, HTN, and DYS, the incidence rate (IR) of T2DM in case group was significantly higher than that in the control group (IR per 1,000, 19.0 vs. 7.3; odds ratio, 2.1; 95% confidence interval, 1.3 to 3.2). The co-existence of HTN, DYS, and ESRD with CMV diseases did not influence the IR of T2DM.

Conclusion

CMV diseases increase the patients' risk of developing T2DM.

Citations

Citations to this article as recorded by  
  • An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta)
    John P. Capitanio, Laura A. Del Rosso, JoAnn Yee, Marie‐Josee Marie‐France Lemoy
    Journal of Medical Primatology.2024;[Epub]     CrossRef
  • Virus-induced diabetes mellitus: revisiting infection etiology in light of SARS-CoV-2
    Sundararaj Stanleyraj Jeremiah, Abu Saleh Md Moin, Alexandra E. Butler
    Metabolism.2024; 156: 155917.     CrossRef
  • Is Pollution the Primary Driver of Infectious Syndemics?
    Merrill Singer
    Pathogens.2024; 13(5): 370.     CrossRef
  • Connecting the Dots: How Herpes Viruses Influence Type 2 Diabetes: Insights from Experimental Researches
    Ushna Zameer, Eisha Saqib, Muhammad Salman Munshi, Samia Rohail
    Clinical Medicine Insights: Endocrinology and Diabetes.2024;[Epub]     CrossRef
  • Exploring pathological link between antimicrobial and amyloid peptides
    Yijing Tang, Yanxian Zhang, Dong Zhang, Yonglan Liu, Ruth Nussinov, Jie Zheng
    Chemical Society Reviews.2024; 53(17): 8713.     CrossRef
  • Infections and immunity: associations with obesity and related metabolic disorders
    Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
    Journal of Pathology and Translational Medicine.2023; 57(1): 28.     CrossRef
  • The effects of cytomegalovirus on brain structure following sport-related concussion
    Jonathan Savitz, Bryna D Goeckner, Bart N Ford, T Kent Teague, Haixia Zheng, Jaroslaw Harezlak, Rebekah Mannix, L Tugan Muftuler, Benjamin L Brett, Michael A McCrea, Timothy B Meier
    Brain.2023; 146(10): 4262.     CrossRef
  • Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence
    Rachel Wong, Emily Lam, Carolyn T. Bramante, Steven G. Johnson, Jane Reusch, Kenneth J. Wilkins, Hsin-Chieh Yeh
    Current Diabetes Reports.2023; 23(8): 207.     CrossRef
  • Epidemiological changes in cytomegalovirus end-organ diseases in a developed country: A nationwide, general-population-based study
    Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Joohee Lim, Yeonju La, Da Eun Kwon, Sang Hoon Han
    Journal of Microbiology, Immunology and Infection.2022; 55(5): 812.     CrossRef
  • Human MicroRNAs Attenuate the Expression of Immediate Early Proteins and HCMV Replication during Lytic and Latent Infection in Connection with Enhancement of Phosphorylated RelA/p65 (Serine 536) That Binds to MIEP
    Yeon-Mi Hong, Seo Yeon Min, Dayeong Kim, Subin Kim, Daekwan Seo, Kyoung Hwa Lee, Sang Hoon Han
    International Journal of Molecular Sciences.2022; 23(5): 2769.     CrossRef
  • Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
    Swapna Thomas, Allal Ouhtit, Hebah A. Al Khatib, Ali H. Eid, Shilu Mathew, Gheyath K. Nasrallah, Mohamed M. Emara, Muna A. Al Maslamani, Hadi M. Yassine
    Journal of Infection and Public Health.2022; 15(4): 412.     CrossRef
  • Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort
    Tim Woelfle, Birgit Linkohr, Tim Waterboer, Barbara Thorand, Jochen Seissler, Marc Chadeau-Hyam, Annette Peters
    Diabetologia.2022; 65(8): 1328.     CrossRef
  • Association of pyogenic spondylitis with congestive heart failure in Korea: a nationwide longitudinal cohort study
    Chong Jin Park, Seung Hun Sheen, Jeong Gyun Kim, Hakyung Kim, Yeo Song Kim, In-bo Han, Je Beom Hong, Chun Kee Chung, Seil Sohn
    Journal of Korean Society of Geriatric Neurosurgery.2022; 18(1): 8.     CrossRef
  • The Role of CMV Infection in Primary Lesions, Development and Clinical Expression of Atherosclerosis
    Carmen Valentina Cristescu, Sophie Alain, Simona Maria Ruță
    Journal of Clinical Medicine.2022; 11(13): 3832.     CrossRef
  • Type 2 diabetes and viral infection; cause and effect of disease
    Tamara Turk Wensveen, Dora Gašparini, Dario Rahelić, Felix M. Wensveen
    Diabetes Research and Clinical Practice.2021; 172: 108637.     CrossRef
  • Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence
    James S. Díaz, Fabián A. Jaimes
    Progress in Transplantation.2021; 31(2): 126.     CrossRef
  • Prevalence of carbohydrate metabolism disorders in patients with new coronavirus infection
    T. N. Markova, M. A. Lysenko, A. A. Ivanova, E. S. Pavlova, A. A. Ponomareva, V. V. Chibisova, T. K. Isaev, D. O. Sinyavkin, A. M. Mkrtumyan
    Diabetes mellitus.2021; 24(3): 222.     CrossRef
  • Immunological Mechanisms of Sickness Behavior in Viral Infection
    Mia Krapić, Inga Kavazović, Felix M. Wensveen
    Viruses.2021; 13(11): 2245.     CrossRef
  • Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study
    Kyoung Hwa Lee, Da Eun Kwon, Kyung Do Han, Yeonju La, Sang Hoon Han
    BMC Neurology.2020;[Epub]     CrossRef
Others
Factors Associated with Improved Glycemic Control by Direct-Acting Antiviral Agent Treatment in Egyptian Type 2 Diabetes Mellitus Patients with Chronic Hepatitis C Genotype 4
Alaaeldin Abdelsalam Dawood, Mohamed Zakarya Nooh, Ayman Abdelhaleem Elgamal
Diabetes Metab J. 2017;41(4):316-321.   Published online August 22, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.4.316
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AbstractAbstract PDFPubReader   
Background

The association of chronic hepatitis C virus (HCV) infection with type 2 diabetes mellitus (T2DM) was first reported in 1994. Little is known about the effect of direct-acting antiviral agents (DAAs) on glycemic control in T2DM patients. The aim of the present study was to evaluate the factors associated with improved glycemic control (IGC) by DAA treatment in Egyptian T2DM patients with chronic HCV genotype 4 infection.

Methods

This study included 460 T2DM patients with chronic HCV genotype 4 infection. Four hundred patients received DAAs and 60 patients did not receive DAAs. Patients with sustained virological response after 3 months of DAAs (378 patients) were allocated into two groups: first group included 292 patients (77.2%) with IGC and second group included 86 patients (22.8%) with non-improved glycemic control (NIGC).

Results

In IGC group, 78 patients (26.7%) needed to decrease the dose of antidiabetic treatment. There were no significant differences between IGC and NIGC groups as regards age, sex, and body mass index. The percentage of patients with positive family history of T2DM, those with Child B class and duration of T2DM were significantly higher in NIGC group compared to IGC.

Conclusion

Diabetic patients receiving DAAs should be closely monitored for reduction of antidiabetic drugs especially insulin and sulfonylurea to avoid hypoglycemic events. Improvement of glycemic control with DAAs is more in patients without family history of T2DM, short duration of diabetes mellitus, and mild liver disease.

Citations

Citations to this article as recorded by  
  • Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review
    Annalisa Cespiati, Inês Coelho Rodrigues, Inês Santos, Sara Policarpo, Sofia Carvalhana, Anna Ludovica Fracanzani, Helena Cortez‐Pinto
    Liver International.2024; 44(5): 1075.     CrossRef
  • The role of treatment of hepatitis C with direct‐acting antiviral agents on glycaemic control in diabetic patients: An updated systematic review and meta‐analysis
    Bing Chen, Umair Iqbal, Shivani K. Desai, Jacob Gries, Elijah Verheyen, Mengdan Xie, Maan El Halabi, Sara Gaines, Ilan Weisberg
    Journal of Viral Hepatitis.2024; 31(10): 633.     CrossRef
  • Prediction of response to sofosbuvir-based therapy using serum interleukin-12 and single nucleotide polymorphism of the interleukin 28B gene as predictive factors in HCV positive genotype-4 patients
    Doaa Mohamed Abdelnajid, Ahmed Y. Elmowafy, Lionel Rostaing, Marwa T. Elrakaiby
    Medicine.2023; 102(28): e34125.     CrossRef
  • Hypoglycemia associated with direct‐acting anti‐hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)
    Yu Zhou, Wenhuo Xie, Chenhua Zheng, Libin Liu, Zhou Chen, Xiaolu Wang
    Clinical Endocrinology.2022; 96(5): 690.     CrossRef
  • Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response
    Sara Cuesta-Sancho, Mercedes Márquez-Coello, Francisco Illanes-Álvarez, Denisse Márquez-Ruiz, Ana Arizcorreta, Fátima Galán-Sánchez, Natalia Montiel, Manuel Rodriguez-Iglesias, José-Antonio Girón-González
    World Journal of Hepatology.2022; 14(1): 62.     CrossRef
  • Therapy of Chronic Viral Hepatitis: The Light at the End of the Tunnel?
    Giorgio Maria Saracco, Alfredo Marzano, Mario Rizzetto
    Biomedicines.2022; 10(3): 534.     CrossRef
  • Hépatite B et C: une mise à jour sur lʼhépatite virale chronique
    Marie Ongaro, Francesco Negro
    Schweizer Gastroenterologie.2022; 3(1): 19.     CrossRef
  • Effect of achieving sustained virological response with direct-acting antiviral agents on glycemic control in diabetic patients with chronic hepatitis C infection
    Mohamed El-Kassas, Runia El-Folly, Maram Aboromia, Heba Aly, Mohamed Bahgat, Mostafa Hamed
    Egyptian Liver Journal.2022;[Epub]     CrossRef
  • Hepatitis C virus infection and diabetes: A complex bidirectional relationship
    Stefano Ciardullo, Alessandro Mantovani, Antonio Ciaccio, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
    Diabetes Research and Clinical Practice.2022; 187: 109870.     CrossRef
  • Does Hepatitis C Virus Treatment by Directly Acting Antivirals Obligate Shifting Patients with Type 2 Diabetes from Oral Hypoglycemic Drugs to Insulin Therapy?
    Rasha Youssef Hagag, Ahmed Fawzy Selim, Omneya Darrag, Hassan Zied, Mohamed Sabry Aboelnasr
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1261.     CrossRef
  • Metabolic changes in chronic hepatitis C patients receiving direct acting antivirals
    Nehal K. Abdel Fattah, Sara M. Shaheen, Osama A. Ahmed, Kadry Elsaeed, Nagwa A. Sabri
    F1000Research.2022; 11: 649.     CrossRef
  • Hepatitis C virus, insulin resistance, and diabetes: A review
    Nabeel Alzahrani
    Microbiology and Immunology.2022; 66(10): 453.     CrossRef
  • The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis
    Marian-Sorin Popescu, Andrei Ioan Drocas, Andrei Osman, Dan-Mihai Firu, Vlad Pădureanu, Cristina Maria Mărginean, Daniel-Cristian Pîrvu, Radu Mitruț, Dragoș Nicolae Mărgăritescu, Antonia Radu, Daniela Calina, Anca Oana Docea, Paul Mitruț
    Reports.2022; 5(4): 42.     CrossRef
  • Global longitudinal strain as a predictor of short-term effect of oral antiviral regimens on myocardium in Egyptian patients with chronic viral hepatitis C
    Hazem Mohammad-Ali Farrag, Mina Samir Monir, Wael Soliman Abdel-Dayem, Hisham Abdel-Haleem Ali, Alaa Mohammad Ibrahim
    The Egyptian Heart Journal.2021;[Epub]     CrossRef
  • Residual risk of liver disease after hepatitis C virus eradication
    Francesco Negro
    Journal of Hepatology.2021; 74(4): 952.     CrossRef
  • Extrahepatic Manifestations of Chronic HCV Infection
    Dan L. Longo, Patrice Cacoub, David Saadoun
    New England Journal of Medicine.2021; 384(11): 1038.     CrossRef
  • Metabolic Evaluation in Patients With Hepatitis C Treated With Direct Antiviral Agents
    Sergio Estefan, Carlos Eduardo Brandão-Melo, Cintia Marques dos Santos Silva, Danilo Cosme Klein Gomes, Paula Cardoso, Marcia Helena S. Costa
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Current situation of viral hepatitis in Egypt
    Ashraf Elbahrawy, Marwa K. Ibrahim, Ahmed Eliwa, Mohamed Alboraie, Ali Madian, Hussein Hassan Aly
    Microbiology and Immunology.2021; 65(9): 352.     CrossRef
  • The impact of direct-acting antiviral treatment on glycemic homeostasis in patients with chronic hepatitis C
    Marco SACCO, Giorgio M. SARACCO
    Minerva Gastroenterology.2021;[Epub]     CrossRef
  • The impact of HCV eradication on hyperglycemia, insulin resistance, cytokine production, and insulin receptor substrate-1 and 2 expression in patients with HCV infection
    Basant Mahmoud, Adel Abdel Moneim, Doaa Mabrouk
    Clinical and Experimental Medicine.2021; 22(4): 583.     CrossRef
  • Systematic review: chronic viral hepatitis and metabolic derangement
    Chia‐Chi Wang, Pin‐Nan Cheng, Jia‐Horng Kao
    Alimentary Pharmacology & Therapeutics.2020; 51(2): 216.     CrossRef
  • Effect of treatment with direct antiviral agents (DAAs) on glycemic control in patients with type 2 diabetes mellitus & hepatitis C virus genotype 4
    Hassan Yousef Zied, Nashwa Mohamed Abo Alnasr, Amal Said El-Bendary, Sherief Abd-Elsalam, Rasha Youssef Hagag
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(4): 679.     CrossRef
  • Impact of Treatment with Direct Acting Antiviral Drugs on Glycemic Control in Patients with Hepatitis C and Diabetes Mellitus
    Pradeep Kumar Mada, Matthew E. Malus, Arvin Parvathaneni, Bing Chen, Gabriel Castano, Sharon Adley, Maureen Moore, Michinari Hieda, Mohammed J. Alam, Mark Feldman, John William King
    International Journal of Hepatology.2020; 2020: 1.     CrossRef
  • Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments
    Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier
    Clinical Science.2020; 134(16): 2117.     CrossRef
  • Treatment of Hepatitis C Virus and Long-Term Effect on Glycemic Control
    Jennifer Andres, Michael Barros, Michael Arutunian, Huaqing Zhao
    Journal of Managed Care & Specialty Pharmacy.2020; 26(6): 775.     CrossRef
  • Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy
    Francesco Negro
    Cold Spring Harbor Perspectives in Medicine.2020; 10(4): a036921.     CrossRef
  • The Effect of Viral Clearance Achieved by Direct-Acting Antiviral Agents on Hepatitis C Virus Positive Patients with Type 2 Diabetes Mellitus: A Word of Caution after the Initial Enthusiasm
    Davide Giuseppe Ribaldone, Marco Sacco, Giorgio Maria Saracco
    Journal of Clinical Medicine.2020; 9(2): 563.     CrossRef
  • Metabolic and renal changes in patients with chronic hepatitis C infection after hepatitis C virus clearance by direct‐acting antivirals
    Riccardo Nevola, Luca Rinaldi, Letizia Zeni, Ferdinando C Sasso, Pia C Pafundi, Barbara Guerrera, Aldo Marrone, Mauro Giordano, Luigi E Adinolfi
    JGH Open.2020; 4(4): 713.     CrossRef
  • Effect of eradication of HCV infection by direct-acting antivirals in diabetic HCV-infected patients as regards glycemic control
    Mohamed Mohei El Badry, Doaa Abdelhady Ali, Noha Hamdy Eltaweel, Marwa A. Abdel-Wahed
    Egyptian Liver Journal.2020;[Epub]     CrossRef
  • Direct-acting antiviral agents decrease haemoglobin A1c level in patients with diabetes infected with hepatitis C virus: A systematic review & meta-analysis
    Kamolyut Lapumnuaypol, David Pisarcik, Prapaipan Putthapiban, Weera Sukhumthammarat, Karn Wijarnpreecha, Charat Thongprayoon, Patompong Ungprasert
    Indian Journal of Medical Research.2020; 152(6): 562.     CrossRef
  • Fisiopatología de la hepatitis C y diabetes mellitus. Hacia la cura de dos epidemias en el siglo XXI
    Harold Ariel Muñoz Díaz, Adán José Lúquez Mindiola, Andrés José Gómez Aldana
    Revista Colombiana de Gastroenterología.2019; 34(3): 277.     CrossRef
  • Treatment with direct-acting antivirals improves peripheral insulin sensitivity in non-diabetic, lean chronic hepatitis C patients
    Giacomo Gastaldi, Diana Gomes, Philippe Schneiter, Xavier Montet, Luc Tappy, Sophie Clément, Francesco Negro, Jee-Fu Huang
    PLOS ONE.2019; 14(6): e0217751.     CrossRef
  • The impact of a successful treatment of hepatitis C virus on glyco-metabolic control in diabetic patients: a systematic review and meta-analysis
    Carla Carnovale, Marco Pozzi, Alice Dassano, Francesca D’Addio, Marta Gentili, Carlo Magni, Emilio Clementi, Sonia Radice, Paolo Fiorina
    Acta Diabetologica.2019; 56(3): 341.     CrossRef
  • Sustained Improvement in Type 2 Diabetes Mellitus is Common After Treatment of Hepatitis C Virus With Direct-acting Antiviral Therapy
    Amir Gilad, Zachary P. Fricker, Adam Hsieh, Dylan D. Thomas, Toni Zahorian, David P. Nunes
    Journal of Clinical Gastroenterology.2019; 53(8): 616.     CrossRef
  • Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure
    Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
    Clinical Endocrinology.2019; 90(3): 440.     CrossRef
  • Direct‐acting antivirals for HCV treatment in older patients: A systematic review and meta‐analysis
    Rosanna Villani, Matteo Monami, Francesca Di Cosimo, Gilda Fioravanti, Edoardo Mannucci, Gianluigi Vendemiale, Gaetano Serviddio
    Journal of Viral Hepatitis.2019; 26(11): 1249.     CrossRef
  • Chronic Hepatitis C Association with Diabetes Mellitus and Cardiovascular Risk in the Era of DAA Therapy
    Sylvia Drazilova, Jakub Gazda, Martin Janicko, Peter Jarcuska
    Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1.     CrossRef
  • The comprehensive outcomes of hepatitis C virus infection: A multi‐faceted chronic disease
    Zobair Younossi, Georgios Papatheodoridis, Patrice Cacoub, Francesco Negro, Heiner Wedemeyer, Linda Henry, Angelos Hatzakis
    Journal of Viral Hepatitis.2018; 25(S3): 6.     CrossRef
  • Poor Glycemic Control and Abrupt Onset of Diabetes in HCV Patients Receiving direct-acting Antiviral Drugs: Case Series
    Braira Wahid, Muhammad Wasim, Komal Saleem, Muhammad Waqar, Sajjad, Khansa Wahid, Manzoor Hussain, Muhammad Idrees
    Future Virology.2018; 13(8): 525.     CrossRef
  • Risk of diabetes in HIV‐infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort
    A. Provoost, M. Dramé, L. Cotte, L. Cuzin, R. Garraffo, D. Rey, F. Raffi, I. Poizot‐Martin, P. Pugliese, F. Bani‐Sadr
    Alimentary Pharmacology & Therapeutics.2018; 48(3): 281.     CrossRef
  • The effect of sustained virological response by direct-acting antivirals on insulin resistance and diabetes mellitus in patients with chronic hepatitis C
    Luigi Elio Adinolfi, Luca Rinaldi, Aldo Marrone, Mauro Giordano
    Expert Review of Anti-infective Therapy.2018; 16(8): 595.     CrossRef
  • Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals
    Sylvia Drazilova, Martin Janicko, Lubomir Skladany, Pavol Kristian, Marian Oltman, Maria Szantova, Dusan Krkoska, Eva Mazuchova, Lubica Piesecka, Veronika Vahalova, Marek Rac, Ivan Schreter, Ladislav Virag, Tomas Koller, Adriana Liptakova, Miriam Ondrasov
    Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1.     CrossRef
  • INSULIN RESISTANCE REDUCTION AFTER SUSTAINED VIROLOGICAL RESPONSE WITH DIRECT ACTING ANTIVIRAL:NOT EVERY POPULATION IMPROVES
    Vanessa Gutierrez de ANDRADE, Fábio da Silva YAMASHIRO, Cássio Vieira OLIVEIRA, Alecsandro MOREIRA, Fernanda Cristina WINCKLER, Giovanni Faria SILVA
    Arquivos de Gastroenterologia.2018; 55(3): 274.     CrossRef
  • Expert Opinion on Managing Chronic HCV Infection in Patients with Type 2 Diabetes Mellitus
    Luigi Elio Adinolf, Ira Jacobson, Mark Bondin, Patrice Cacoub
    Antiviral Therapy.2018; 23(1_suppl): 11.     CrossRef
Review
Functional and Mechanistic Integration of Infection and the Metabolic Syndrome
Peter Sommer, Gary Sweeney
Korean Diabetes J. 2010;34(2):71-76.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.71
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AbstractAbstract PDFPubReader   

The metabolic syndrome refers to a well defined group of risk factors, including central obesity and inflammation, for the development of diabetes and cardiovascular disease. Interestingly, many studies have recently led to the emergence of somewhat unexpected relationships between several infectious diseases and various aspects of the metabolic syndrome. Our understanding of the mechanisms underlying these interactions is also rapidly developing and some of these are summarized in this article. We will focus first on bacterial infection, and most notably the role of gut microbiota in regulaton of both obesity and inflammation. In particular, we focus on the role of inflammasomes and propose that understanding the role of Toll-like receptors and Nod-like receptors in the pathogenesis of inflammatory disorders with or without infection may provide novel targets for prevention and/or treatment of associated diseases. Secondly, chronic bacterial or viral infection and emerging links with metabolism will be reviewed. Finally, consideratons of biomarkers for metabolic syndrome, in particular lipocalin-2, and their link with infection will be discussed.

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  • The immunology of sickness metabolism
    Felix M. Wensveen, Marko Šestan, Bojan Polić
    Cellular & Molecular Immunology.2024; 21(9): 1051.     CrossRef
  • The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome
    Timea Claudia Ghitea, Amina El-Kharoubi, Mariana Ganea, Erika Bimbo-Szuhai, Tiberiu Sebastian Nemeth, Gabriela Ciavoi, Monica Foghis, Luciana Dobjanschi, Annamaria Pallag, Otilia Micle
    Molecules.2021; 26(2): 283.     CrossRef
  • COVID-19 severity in relation to sociodemographics and vitamin D use
    Darya Saeed Abdulateef, Heshu Sulaiman Rahman, Jamal Mahmood Salih, Sangar Mahmoud Osman, Trifa Abdalla Mahmood, Shirwan Hama Salih Omer, Rana Adnan Ahmed
    Open Medicine.2021; 16(1): 591.     CrossRef
  • Iron Reshapes the Gut Microbiome and Host Metabolism
    Amy Botta, Nicole G. Barra, Nhat Hung Lam, Samantha Chow, Kostas Pantopoulos, Jonathan D. Schertzer, Gary Sweeney
    Journal of Lipid and Atherosclerosis.2021; 10(2): 160.     CrossRef
  • Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection
    Anil Pant, Lara Dsouza, Zhilong Yang, Benjamin Gewurz, Vinayaka R. Prasad
    mBio.2021;[Epub]     CrossRef
  • Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome
    Altansuvd Enkhtur, Joon-Sup Yoon, Chang-Woo Lee
    Precision and Future Medicine.2020; 4(3): 83.     CrossRef
  • Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes
    Erfei Song, Sofhia V. Ramos, Xiaojing Huang, Ying Liu, Amy Botta, Hye Kyoung Sung, Patrick C. Turnbull, Michael B. Wheeler, Thorsten Berger, Derek J. Wilson, Christopher G. R. Perry, Tak W. Mak, Gary Sweeney
    Proceedings of the National Academy of Sciences.2018; 115(7): 1576.     CrossRef
  • Tuberculosis of the Breast: An Initial Presentation of the Metabolic Syndrome with Type 2 Diabetes Mellitus in a Young Nigerian Woman
    M. A. Adeiza, R. Yusuf, A. A. Liman, P. Abur, F. Bello, A. A. Abba
    Case Reports in Infectious Diseases.2016; 2016: 1.     CrossRef
  • Systematic Review of the Relation Between Intestinal Microbiota and Toll-Like Receptors in the Metabolic Syndrome: What Do We Know So Far?
    José Pedro Portela-Cidade, Marta Borges-Canha, Adelino Ferreira Leite-Moreira, Pedro Pimentel-Nunes
    GE Portuguese Journal of Gastroenterology.2015; 22(6): 240.     CrossRef
  • Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
    Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
    International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
  • Regulation of Iron and Its Significance in Obesity and Complications
    Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney
    The Korean Journal of Obesity.2014; 23(4): 222.     CrossRef
  • Direct effects of adipokines on the heart: focus on adiponectin
    Min Park, Gary Sweeney
    Heart Failure Reviews.2013; 18(5): 631.     CrossRef
  • The Thioredoxin System as a Therapeutic Target in Human Health and Disease
    Dler Faieeq Darweesh Mahmood, Amna Abderrazak, Khadija El Hadri, Thomas Simmet, Mustapha Rouis
    Antioxidants & Redox Signaling.2013; 19(11): 1266.     CrossRef
  • Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Wei Qiu, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi
    Annals of Medicine.2013; 45(3): 220.     CrossRef
  • Immunoglobulin E and Mast Cell Proteases Are Potential Risk Factors of Human Pre-Diabetes and Diabetes Mellitus
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi, Yiqing Song
    PLoS ONE.2011; 6(12): e28962.     CrossRef
Original Articles
Treatment of Type 1 Diabetes through Genetically Engineered K-cell Transplantation in a Mouse Model.
Ju Yeon Sim, Ju Hee Kim, Yu Bae Ahn, Ki Ho Song, Je Ho Han, Bong Yun Cha, Sook Kyung Lee, Sung Dae Moon
Korean Diabetes J. 2009;33(6):466-474.   Published online December 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.6.466
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AbstractAbstract PDF
BACKGROUND
K-cells function as targets for insulin gene therapy. In a previous study, we constructed EBV-based plasmids expressing rat preproinsulin controlled by glucose-dependent insulinotropic polypeptide promoters. In the present study, we attempted to correct hyperglycemia in vivo using genetically engineered K-cells in a mouse model of type 1 diabetes. METHODS: K-cells expressing insulin were transplanted under the kidney capsules of STZ-induced diabetic mice. The blood glucose levels and body weights of the experimental animals were measured daily. After four weeks, the mice were injected intra-peritoneally with 2 g/kg glucose following a 6 hr fast. Blood glucose levels were measured immediately following glucose injections. All animals were sacrificed at the end of the glucose tolerance study, and pancreas and graft-bearing kidney tissue samples were stained with antibodies against insulin, glucagon, and C-peptide. RESULTS: The body weights of K-cell-transplanted diabetic mice increased after transplantation, whereas those of untreated diabetic control mice continued to decline. The blood glucose levels of K-cell-transplanted diabetic mice decreased gradually during the two weeks following transplantation. After intra-peritoneal injection of glucose into K-cell-transplanted diabetic mice, blood glucose levels increased at 30 minutes, and were restored to the normal range between 60 and 90 minutes, while untreated control diabetic mice continued to experience hyperglycemia. Kidney capsules containing transplanted K-cells were removed, and sections were stained with anti-insulin antibodies. We detected insulin-positive cells in the kidney capsules of K-cell-transplanted diabetic mice, but not in untreated control mice. CONCLUSION: We detected glucose-dependent insulin secretion in genetically engineered K-cells in a mouse model of type 1 diabetes. Our results suggest that genetically modified insulin producing K-cells may act as surrogate beta-cells to effectively treat type 1 diabetes.
Glucose-dependent Insulin Secretion from Genetically Engineered K-cells Using EBV-based Episomal Vector.
Ju Hee Kim, Sung Dae Moon, Seung Hyun Ko, Yu Bai Ahn, Ki Ho Song, Hyang Sook Lim, Sook Kyung Lee, Soon Jip Yoo, Hyun Shik Son, Kun Ho Yoon, Bong Yun Cha, Ho Young Son, Sung Joo Kim, Je Ho Han
Korean Diabetes J. 2007;31(1):9-21.   Published online January 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.1.9
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  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Type 1 diabetes mellitus is an autoimmune disease resulting in destruction of the pancreatic beta cells. Insulin gene therapy for these patients has been vigorously researched. The strategy for achieving glucose-dependent insulin secretion in gene therapy relies on glucose-responsive transcription of insulin mRNA and the constitutive secretory pathway of target non-beta cells. We observed that genetically engineered K-cells using Epstein-Barr virus (EBV)-based episomal vector can produce glucose-regulated insulin production. METHODS: Green fluorescent protein (GFP) or rat-preproinsulin (PPI) expression cassette transcriptionally controlled by the promoter of glucose dependent insulinotropic peptide (GIPP) is fused to pCEP4 containing the origin of replication (oriP) and Epstein-Barr virus nuclear antigen 1 (EBNA-1). CMV promoter was replaced by subcloning the GIPP into pCEP4 to generate pGIPP/CEP4. Two recombinant EBV-based episomal vectors, pGIPP/GFP/CEP4 and pGIPP/PPI/CEP4, were constructed. pGIPP/GFP/CEP4 and pGIPP/PPI/CEP4 containing K-cell specific GIPP were co-transfected into STC-1. K-cell was isolated from the clonal expansion of the fluorescent cells selected by hygromycin treatment in STC-1, and were analyzed for the expression of glucokinase (GK) or transcription factors involved in pancreas development. K-cells concurrently transfected with pGIPP/PPI/CEP4 and pGIPP/GFP/CEP4 were analyzed for the transcripts of PPI by RT-PCR, and for the glucose dependent insulin expression by immunocytochemistry or insulin assay using ultra-sensitive rat-specific insulin ELISA kit. RESULT: STC-1 was stably-transfected with pGIPP/GFP/CEP4 along with pGIPP/PPI/CEP4. Genetically selected fluorescent K-cells expressed GK and transcription factors involved in pancreas development. And K-cells transfected with pGIPP/PPI/CEP4 contained detectable levels of PPI transcripts and showed glucose-dependent immunoreactive insulin secretion. CONCLUSION: We identified genetically engineered K-cells which exert a glucose-dependent insulin expression using EBV-based episomal vector. The similarities between K-cells and pancreatic beta cells support that K-cells may make effective and ideal targeting cells for insulin gene therapy or alternative cell therapy.

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  • Relationship of traditional and nontraditional cardiovascular risk factors to coronary artery calcium in type 2 diabetes
    Ju-Yeon Sim, Ju-Hee Kim, Yu-Bae Ahn, Ki-Ho Song, Je-Ho Han, Bong-Yun Cha, Sook-Kyung Lee, Sung-Dae Moon
    Korean Diabetes Journal.2009; 33(6): 466.     CrossRef
  • Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells
    Esder Lee, Jun Mo Yu, Min Kyung Lee, Gyeong Ryul Ryu, Seung-Hyun Ko, Yu-Bae Ahn, Sung-Dae Moon, Ki-Ho Song
    Korean Diabetes Journal.2009; 33(6): 475.     CrossRef
Insulin Gene Therapy Using HVJ-liposome and Epstein-Barr Virus Plasmid in Murine Streptozotocin Induced Diabetes.
Yong Deuk Kim, Keun Gyu Park, Seong Wook Han, Jong Doek Ahn, Hyo Jung Lee, Mi Jung Kim, Hye Soon Kim, Nam Hee Park, In Kyu Lee
Korean Diabetes J. 2003;27(5):405-413.   Published online October 1, 2003
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BACKGROUND
Despite improvement in insulin preparation and delivery, the use of insulin therapy alone to maintain normal glucose concentration and prevent the development of diabetic complication is not easy. Therefore, there has been considerable interest in developing gene therapy to supply insulin. We investigated that the administration of hemagglutinating virus of Japan (HVJ)- liposome complex, containing human insulin construct into the portal vein to control the blood glucose level in murine streptozotocin (STZ)-induced diabetes. METHODS: Human insulin gene was delivered to STZ-induced diabetic rats through the portal vein using HVJ-liposome containing Epstein-Barr virus (EBV) replicon-based plasmid (pEB). Blood glucose and body weight were measured after insulin gene delivery. The animals were sacrificed 28 days later and the livers were collected for immuno-histochemical staining of insulin. In addition plasma insulin and C-peptide levels were measured. RESULTS: Significant decrease in blood glucose levels and an increase in insulin and C-peptide levels were observed in the insulin gene transfection group as compared to the control group. Immunohistochemical staining of insulin also showed significant differences between these two groups. CONCLUSION: This study demonstrated the possibility of insulin gene therapy through the portal vein using pEB and HVJ-liposome method to produce a sustained improvement of diabetic glucose metabolism.
Effect of Gi-proteins on Insulin Binding, Internalization and Recycling of Insulin Receptor in Bovine Aorta Endothelial Cell.
Hyuk Ho Kwon, Hyun Shik Son, Jung Min Lee, Seung Hyun Ko, Ok Ki Hong, Sung Dae Moon, Sang Ah Chang, Kun Ho Yoon, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang
Korean Diabetes J. 2003;27(1):26-38.   Published online February 1, 2003
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BACKGROUND
Guanine nucleotide binding proteins (G-proteins) play important roles in the hormonal actions of many signal transduction systems. Possible roles for the Gi-protein in insulin action have been suggested. It is reported that Gi-protein is associated with insulin actions to a greater extent than Gs-protein. There are at least three different subtypes of Gi-proteins (Gi(alpha1), Gi(alpha2), and Gi(alpha3)), however, it is not certain which subtypes are associated with insulin receptors and their action. METHODS: To investigate the effects of Gi-proteins on insulin action, the Gi-proteins were overexpressed in cultured bovine aortic endothelial cells (BAEC), using the DNA-polylysine-adenovirus complex transfection method. After incubating for 24 hours, the BAEC were treated with 200 ng/mL insulin to evaluate the insulin binding, receptor internalization and recycling. RESULTS: The following results were found : 1) The binding of specific insulin bindings to the insulin receptors of endothelial cells were time-dependent, reaching their maximal levels in all cells after 30 minutes. The maximal specific bindings of the control, Gi(alpha1), Gi(alpha2), and Gi(alpha3) were 0.58+/-0.1, 0.54+/-0.08, 0.54+/-0.1, 0.53+/-0.09%, respectively. 2) The internalization of 125I-insulin, into endothelial cells, was assessed by the acid washing dissociation method, and occurred rapidly. There was a significant difference in the internalized radioactivity of the 125I-insulin in the overexpressed Gi(alpha2) protein group compared to the two groups. 3) The recycling of the insulin receptors in the three types of Gi-protein showed no significant difference between the three group. CONCLUSION: In conclusion, the Gi(alpha2) protein may be associated with internalization of the insulin-insulin receptor complex, and appears to be important in both the action of insulin and the intracellular processing of insulin receptors.
The Role of Akt-1/PKBalpha on Insulin Action in 3T3-L1 Adipocyte.
Jung Min Lee, Hyun Shik Son, Hyuk Sang Kwon, Seung Ki Kwack, Seung Hyun Ko, Sang Ah Chang, Kun Ho Yoon, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang, Prem Sharma
Korean Diabetes J. 2002;26(4):274-285.   Published online August 1, 2002
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BACKGROUND
S: Akt/PKB as a serine/threonine kinase is stimulated by insulin and other growth factors. And insulin stimulates glucose uptake by promoting the translocation of glucose transporter 4 (GLUT4) to the cell membrane. But, it is not clear that Akt/PKB, a downstream target of PI 3-kinase, is involved in glucose uptake pathway. In this study, we investigated the role of Akt/PKB, especially Akt-1, on insulin action in 3T3-L1 adipocyte. METHODS: We made recombinant Ad5.Akt-1 vector by the insertion of Akt-1 gene to adenoviral vector. And then, we overexpressed Akt-1 proteins(wild type and kinase inactive type) in 3T3-L1 adipocytes by using a adenoviral transfection method. We observed the changes of glucose uptake, glycogen synthesis, activities of mitogen-activated protein kinase (MAPK, also called extracellular signal-regulated kinase), p70 ribosomal s6 protein kinase (p70s6k), and glycogen synthase kinase 3 (GSK3) according to Akt-1 activity and insulin treatment. RESULTS: First, overexpression of Akt-1 did not affect to glucose uptake, whether insulin stimulates or not. Second, overexpression of Akt-1 did not affect the phosphorylation of p44/42-MAPK, either. Third, the glycogen synthesis was increased by overexpression of Akt-1. CONCLUSION: Akt-1 activation is necessary for glycogen synthesis, but is not essential for glucose transport in 3T3-L1 adipocytes.

Diabetes Metab J : Diabetes & Metabolism Journal
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