Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Vaspin"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance
Alireza Esteghamati, Sina Noshad, Mostafa Mousavizadeh, Ali Zandieh, Manouchehr Nakhjavani
Diabetes Metab J. 2014;38(2):143-149.   Published online April 18, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.2.143
  • 3,147 View
  • 33 Download
  • 24 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   
Background

Previous studies evaluating the relationship between serum vaspin concentrations and metabolic syndrome (MetS) have yielded contrasting results. Additionally, contribution of general and abdominal obesity, chronic inflammation, and insulin resistance to this relationship remains unknown.

Methods

In a cross-sectional setting, we investigated the association between vaspin and MetS in 145 subjects ranging from normoglycemia to type 2 diabetes. Vaspin concentrations were measured using enzyme-linked immunosorbent assay.

Results

Women had 29% higher vaspin concentrations compared with men. Subjects with MetS (51% of all participants) had higher vaspin concentrations (P=0.019 in women and P<0.001 in men). In logistic regression, vaspin significantly predicted raised fasting plasma glucose (P<0.001), and raised triglycerides (P<0.001) after controlling for age in both sexes. Moreover, vaspin was the significant predictor for reduced high-density lipoprotein cholesterol and raised waist circumference in women and men, respectively. Considering MetS as a whole, vaspin predicted MetS even after adjustment for age, medications, diabetes, total cholesterol, and waist circumference in both sexes (odds ratio [OR], 3.88; 95% confidence interval [CI], 1.36 to 11.05; P=0.011 for women; OR, 3.16; 95% CI, 1.28 to 7.78; P=0.012 for men). However, this relationship rendered nonsignificant after introducing homeostasis model assessment of insulin resistance (HOMA-IR) in women (P=0.089) and high-sensitivity C-reactive protein (P=0.073) or HOMA-IR in men (P=0.095).

Conclusion

Vaspin is associated with some but not all components of MetS. Vaspin is a predictor of MetS as a single entity, independent of obesity. This relationship is largely ascribed to the effects of insulin resistance and chronic inflammation.

Citations

Citations to this article as recorded by  
  • The role of rs2236242 at SERPINA12 gene and vaspin level on papillary thyroid carcinoma
    Sahar Torki, Masoumeh Nezhadali, Mehdi Hedayati, Helma Karimi, S. Adeleh Razavi, Leila Najd Hassan Bonab
    Nucleosides, Nucleotides & Nucleic Acids.2024; : 1.     CrossRef
  • Association of vaspin rs2236242 gene polymorphism with serum vaspin level, insulin resistance and diabetes in an Iranian diabetic/pre-diabetic population
    Maria Hosseini, Masoumeh Nezhadali, Mehdi Hedayati
    Journal of Medical Biochemistry.2021; 40(1): 33.     CrossRef
  • Adipokines in vascular calcification
    Xuan Xiao, Yi-Zhang Liu, Zhe-Bin Cheng, Jia-Xiang Sun, Yi-Duo Shao, Shun-Lin Qu, Liang Huang, Chi Zhang
    Clinica Chimica Acta.2021; 516: 15.     CrossRef
  • Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
    Javier Rueda-Gotor, Raquel López-Mejías, Sara Remuzgo-Martínez, Verónica Pulito-Cueto, Alfonso Corrales, Leticia Lera-Gómez, Virginia Portilla, Íñigo González-Mazón, Ricardo Blanco, Rosa Expósito, Cristina Mata, Javier Llorca, Vanesa Hernández-Hernández,
    Arthritis Research & Therapy.2021;[Epub]     CrossRef
  • Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
    Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Małgorzata Jurek, Dominika Klimczyk, Joelle Dupont, Agnieszka Rak
    Cells.2021; 10(7): 1710.     CrossRef
  • The Role of Anti-Inflammatory Adipokines in Cardiometabolic Disorders: Moving beyond Adiponectin
    Han Na Jung, Chang Hee Jung
    International Journal of Molecular Sciences.2021; 22(24): 13529.     CrossRef
  • Pathophysiology of Type 2 Diabetes Mellitus
    Unai Galicia-Garcia, Asier Benito-Vicente, Shifa Jebari, Asier Larrea-Sebal, Haziq Siddiqi, Kepa B. Uribe, Helena Ostolaza, César Martín
    International Journal of Molecular Sciences.2020; 21(17): 6275.     CrossRef
  • Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome
    E Suliga, D Kozieł, E Cieśla, D Rębak, M Wawszczak, W Adamus-Białek, E Naszydłowska, A Piechowska, S Głuszek
    Balkan Journal of Medical Genetics.2019; 22(1): 41.     CrossRef
  • Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity
    Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker, Simon W Jones
    Journal of Endocrinology.2019; 241(1): 31.     CrossRef
  • Anti-Atherogenic Effects of Vaspin on Human Aortic Smooth Muscle Cell/Macrophage Responses and Hyperlipidemic Mouse Plaque Phenotype
    Kengo Sato, Remina Shirai, Maho Yamaguchi, Tomoyuki Yamashita, Koichiro Shibata, Taisuke Okano, Yusaku Mori, Taka-aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
    International Journal of Molecular Sciences.2018; 19(6): 1732.     CrossRef
  • Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?
    Fereshteh Aliasghari, Azimeh Izadi, Masoumeh Jabbari, Bahareh Imani, Bahram Pourghassem Gargari, Foad Asjodi, Sara Ebrahimi
    Journal of Medical Biochemistry.2018; 37(4): 470.     CrossRef
  • Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus
    Dalia H. El-Lebedy, Alshaymaa A. Ibrahim, Ingy O. Ashmawy
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(5): 643.     CrossRef
  • Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population
    F Genske, J-P Kühn, M Pietzner, G Homuth, W Rathmann, H J Grabe, H Völzke, H Wallaschofski, N Friedrich
    International Journal of Obesity.2018; 42(2): 183.     CrossRef
  • Obesity risk prediction among women of Upper Egypt: The impact of serum vaspin and vaspin rs2236242 gene polymorphism
    Soad M. Abdel Ghany, Ayat A. Sayed, Sahar E.M. El-Deek, Hala M. ElBadre, Marwa A. Dahpy, Medhat A. Saleh, Hanan Sharaf El-Deen, Mohamed H. Mustafa
    Gene.2017; 626: 140.     CrossRef
  • Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size
    Shahab Alizadeh, Khadijeh Mirzaei, Chonur Mohammadi, Seyed Ali Keshavarz, Zhila Maghbooli
    Archives of Endocrinology and Metabolism.2017; 61(6): 567.     CrossRef
  • Changes in four plasma adipokines before and after sleep in OSAS patients
    Ting Xu, Yong Lin, Siqing Sun, Qiang Zhang
    The Clinical Respiratory Journal.2017; 11(6): 968.     CrossRef
  • Association of circulating adipokines with metabolic dyslipidemia in obese versus non-obese individuals
    Mehran Rahimlou, Khadijeh Mirzaei, Seyed Ali Keshavarz, Arash Hossein-nezhad
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(1): S60.     CrossRef
  • The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy
    Umut Balli, Seyma Bozkurt Dogan, Figen Ongoz Dede, Erdim Sertoglu, Gonca Cayır Keles
    Journal of Oral Science.2016; 58(4): 465.     CrossRef
  • The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis
    Rumyana Dimova, Tsvetalina Tankova
    BioMed Research International.2015; 2015: 1.     CrossRef
  • Letter: Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance (Diabetes Metab J2014;38:143-9)
    Sung Hee Choi
    Diabetes & Metabolism Journal.2014; 38(3): 240.     CrossRef
  • Response: Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance (Diabetes Metab J2014;38:143-9)
    Alireza Esteghamati, Sina Noshad, Mostafa Mousavizadeh, Ali Zandieh, Manouchehr Nakhjavani
    Diabetes & Metabolism Journal.2014; 38(3): 242.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer