Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
21 "Vascular complication"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Complications
The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both?
Dora M. Gorman, Carel W. le Roux, Neil G. Docherty
Diabetes Metab J. 2016;40(5):354-364.   Published online September 27, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.354
  • 4,652 View
  • 49 Download
  • 25 Web of Science
  • 28 Crossref
AbstractAbstract PDFPubReader   

Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals. Intensive medical management of hyperglycemia is associated with improved microvascular outcomes. Whether or not the reduction in hyperglycemia observed after bariatric surgery translates to improved microvascular outcomes is yet to be determined. There is substantial heterogeneity in the data relating to the impact of bariatric surgery on diabetic retinopathy (DR), the most common microvascular complication of diabetes. This review aims to collate the recent data on retinal outcomes after bariatric surgery. This comprehensive evaluation revealed that the majority of DR cases remain stable after surgery. However, risk of progression of pre-existing DR and the development of new DR is not eliminated by surgery. Instances of regression of DR are also noted. Potential risk factors for deterioration include severity of DR at the time of surgery and the magnitude of glycated hemoglobin reduction. Concerns also exist over the detrimental effects of postprandial hypoglycemia after surgery. In vivo studies evaluating the chronology of DR development and the impact of bariatric surgery could provide clarity on the situation. For now, however, the effect of bariatric surgery on DR remains inconclusive.

Citations

Citations to this article as recorded by  
  • Author response to: remission of diabetes mellitus after bariatric surgery: the putative link with worsening diabetic retinopathy and a need for ongoing postoperative follow-up retinal screening
    Karl Hage, Omar M. Ghanem
    Surgery for Obesity and Related Diseases.2024; 20(5): 499.     CrossRef
  • Impact of Bariatric Surgery on Treatment Burden and Progression of Diabetic Retinopathy
    Ariana Allen, Hemal Patel, Sandra S. Stinnett, Jullia A. Rosdahl, Stefanie Schuman
    Journal of VitreoRetinal Diseases.2024; 8(3): 263.     CrossRef
  • Role of Systemic Factors in Improving the Prognosis of Diabetic Retinal Disease and Predicting Response to Diabetic Retinopathy Treatment
    Joe Mellor, Anita Jeyam, Joline W.J. Beulens, Sanjeeb Bhandari, Geoffrey Broadhead, Emily Chew, Ward Fickweiler, Amber van der Heijden, Daniel Gordin, Rafael Simó, Janet Snell-Bergeon, Anniina Tynjälä, Helen Colhoun
    Ophthalmology Science.2024; 4(4): 100494.     CrossRef
  • The Importance of Glycaemic Control Before Bariatric Surgery: Preventing Microvascular and Metabolic Complications
    Adhithya Sankar, Rajshekhar N. Mudaliar, Rupinder S. Kochhar, Lucinda K. M. Summers, Akheel A. Syed, Waseem Majeed
    Obesity Surgery.2024; 34(6): 2248.     CrossRef
  • Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes
    Rafael Simó, Josep Franch-Nadal, Bogdan Vlacho, Jordi Real, Ester Amado, Juana Flores, Manel Mata-Cases, Emilio Ortega, Mercedes Rigla, Joan-Anton Vallés, Cristina Hernández, Didac Mauricio
    Diabetes Care.2023; 46(9): 1633.     CrossRef
  • Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates
    Kalie L. Tommerdahl, Allison L. B. Shapiro, Edward J. Nehus, Petter Bjornstad
    Pediatric Nephrology.2022; 37(1): 79.     CrossRef
  • New Insights into Treating Early and Advanced Stage Diabetic Retinopathy
    Rafael Simó, Cristina Hernández
    International Journal of Molecular Sciences.2022; 23(15): 8513.     CrossRef
  • Response to Letter to the Editor Concerning: Adam S. et al. Improvements in Diabetic Neuropathy and Nephropathy After Bariatric Surgery: a Prospective Cohort Study
    Safwaan Adam, Jan Hoong Ho, Akheel A. Syed, Rayaz A. Malik, Handrean Soran
    Obesity Surgery.2022; 32(10): 3460.     CrossRef
  • Weight management and multi-morbidity
    Carrie Ashby
    InnovAiT: Education and inspiration for general practice.2021; 14(8): 523.     CrossRef
  • The Safety of Pharmacological and Surgical Treatment of Diabetes in Patients with Diabetic Retinopathy—A Review
    Wojciech Matuszewski, Angelika Baranowska-Jurkun, Magdalena Maria Stefanowicz-Rutkowska, Katarzyna Gontarz-Nowak, Ewa Gątarska, Elżbieta Bandurska-Stankiewicz
    Journal of Clinical Medicine.2021; 10(4): 705.     CrossRef
  • Safety of Semaglutide
    Mark M. Smits, Daniël H. Van Raalte
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Outcomes of Diabetic Retinopathy Post-Bariatric Surgery in Patients with Type 2 Diabetes Mellitus
    Ana Maria Dascalu, Anca Pantea Stoian, Alina Popa Cherecheanu, Dragos Serban, Daniel Ovidiu Costea, Mihail Silviu Tudosie, Daniela Stana, Denisa Tanasescu, Alexandru Dan Sabau, Gabriel Andrei Gangura, Andreea Cristina Costea, Vanessa Andrada Nicolae, Cata
    Journal of Clinical Medicine.2021; 10(16): 3736.     CrossRef
  • Future perspectives in diabesity treatment: Semaglutide, a glucagon‑like peptide 1 receptor agonist (Review)
    Mariana Tilinca, Robert Tiuca, Cristina Niculas, Andreea Varga, Ioan Tilea
    Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
  • Safety of injectable semaglutide for type 2 diabetes
    Rajesh Peter, Steve C. Bain
    Expert Opinion on Drug Safety.2020; 19(7): 785.     CrossRef
  • Early worsening of diabetic retinopathy due to intensive glycaemic control
    Shueh Wen Lim, Peter van Wijngaarden, Colin A. Harper, Salmaan H. Al‐Qureshi
    Clinical & Experimental Ophthalmology.2019; 47(2): 265.     CrossRef
  • Worsening of diabetic retinopathy with rapid improvement in systemic glucose control: A review
    Stephen C. Bain, Michael A. Klufas, Allen Ho, David R. Matthews
    Diabetes, Obesity and Metabolism.2019; 21(3): 454.     CrossRef
  • Diabetische Retinopathie bei Patienten mit Diabetes mellitus
    Olga Simó-Servat, Cristina Hernández, Rafael Simó
    Kompass Ophthalmologie.2019; 5(4): 157.     CrossRef
  • Diabetic Retinopathy in the Context of Patients with Diabetes
    Olga Simó-Servat, Cristina Hernández, Rafael Simó
    Ophthalmic Research.2019; 62(4): 211.     CrossRef
  • MANAGEMENT OF ENDOCRINE DISEASE: Which metabolic procedure? Comparing outcomes in sleeve gastrectomy and Roux-en Y gastric bypass
    Adrian T Billeter, Javier R de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat P Müller-Stich
    European Journal of Endocrinology.2018; 179(2): R77.     CrossRef
  • Aggravation précoce de la rétinopathie diabétique lors de l’optimisation du contrôle glycémique
    S. Feldman-Billard
    Médecine des Maladies Métaboliques.2018; 12(7): 560.     CrossRef
  • Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy
    Tina Vilsbøll, Stephen C. Bain, Lawrence A. Leiter, Ildiko Lingvay, David Matthews, Rafael Simó, Ida Carøe Helmark, Nelun Wijayasinghe, Michael Larsen
    Diabetes, Obesity and Metabolism.2018; 20(4): 889.     CrossRef
  • Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Incident Diabetic Retinopathy
    Antonios Douros, Kristian B. Filion, Hui Yin, Oriana Hoi Yu, Mahyar Etminan, Jacob A. Udell, Laurent Azoulay
    Diabetes Care.2018; 41(11): 2330.     CrossRef
  • Early worsening of diabetic retinopathy after rapid improvement of blood glucose control in patients with diabetes
    S. Feldman-Billard, É. Larger, P. Massin
    Diabetes & Metabolism.2018; 44(1): 4.     CrossRef
  • Excess visceral adiposity is associated with diabetic retinopathy in a multiethnic Asian cohort with longstanding type 2 diabetes
    Angela Moh, Kumari Neelam, Xiao Zhang, Chee Fang Sum, Subramaniam Tavintharan, Keven Ang, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim
    Endocrine Research.2018; 43(3): 186.     CrossRef
  • GLP-1R as a Target for the Treatment of Diabetic Retinopathy: Friend or Foe?
    Rafael Simó, Cristina Hernández
    Diabetes.2017; 66(6): 1453.     CrossRef
  • The Long-Term Effects of Bariatric Surgery on Type 2 Diabetes Remission, Microvascular and Macrovascular Complications, and Mortality: a Systematic Review and Meta-Analysis
    Binwu Sheng, Khoa Truong, Hugh Spitler, Lu Zhang, Xuetao Tong, Liwei Chen
    Obesity Surgery.2017; 27(10): 2724.     CrossRef
  • Bariatric Surgery for Adolescents with Type 2 Diabetes: an Emerging Therapeutic Strategy
    M. A. Stefater, T. H. Inge
    Current Diabetes Reports.2017;[Epub]     CrossRef
  • The role of bariatric surgery to treat diabetes: current challenges and perspectives
    Chrysi Koliaki, Stavros Liatis, Carel W. le Roux, Alexander Kokkinos
    BMC Endocrine Disorders.2017;[Epub]     CrossRef
Original Articles
Epidemiology
The Association between Hypertension Comorbidity and Microvascular Complications in Type 2 Diabetes Patients: A Nationwide Cross-Sectional Study in Thailand
Cameron Hurst, Bandit Thinkhamrop, Hoang The Tran
Diabetes Metab J. 2015;39(5):395-404.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.395
  • 3,995 View
  • 51 Download
  • 28 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes mellitus (T2DM) is a global pandemic and its prevalence is rapidly increasing in developing countries, including Thailand. The most common comorbidity of T2DM is hypertension. T2DM with a hypertension comorbidity is likely to exacerbate the development of, or more severe microvascular complications. This study aims to determine the association between the hypertension comorbidity and microvascular complication among T2DM patients in Thailand.

Methods

The present study is a nationwide, multicenter, cross-sectional survey of T2DM outpatients across Thailand. Binary logistic mixed effect regression was used to investigate the effect of hypertension and other risk factors on the presence of microvascular complications. Imputation was used to investigate potential bias introduced by missing values.

Results

Of the 55,797 T2DM patients included in our sample, 55.35% were hypertensive. Prevalence of microvascular complication diagnosis in the last 12 months was higher in T2DM patients with hypertension than those without hypertension (12.12% vs. 9.80%, respectively). Patient with a hypertension comorbidity had 1.32 time the odds of developing microvascular complication (adjusted odds ratio [OR], 1.32; 95% confidence interval [CI], 1.20 to 1.46; P<0.001). Older age, longer diabetes duration had 1.07 and 1.21 times the odds of developing microvascular complication, per 10 years (age) and 5 years (duration), respectively (ORage, 1.07; 95% CI, 1.03 to 1.12; P<0.001; and ORduration, 1.12; 95% CI, 1.07 to 1.16; P<0.001; respectively). Minimal bias was introduced by missing values, and did not influence to the magnitude of effect of hypertension on the presence microvascular complication.

Conclusion

Hypertension comorbidity is highly associated with microvascular complication among T2DM patients. Patients with T2DM and physicians should pay attention to blood pressure control.

Citations

Citations to this article as recorded by  
  • Predictors of microvascular complications in patients with type 2 diabetes mellitus at regional referral hospitals in the central zone, Tanzania: a cross-sectional study
    Wilfred B. Shillah, James J. Yahaya, Emmanuel D. Morgan, Deogratius Bintabara
    Scientific Reports.2024;[Epub]     CrossRef
  • Trajectories of Body Mass Index and Risk for Diabetes Complications and All-Cause Mortality in Finnish Type 2 Diabetes Patients
    Zhiting Wang, Piia Lavikainen, Katja Wikström, Tiina Laatikainen
    Clinical Epidemiology.2024; Volume 16: 203.     CrossRef
  • Diabetic microvascular complications and associated factors in patients with type 2 diabetes in Southern Ethiopia
    Fasika Merid, Firdawek Getahun, Habtamu Esubalew, Tamirat Gezahegn
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population
    Asma Salauddin, Kallyan Chakma, Md. Mahbub Hasan, Farhana Akter, Nowshad Asgar Chowdhury, Sumon Rahman Chowdhury, Adnan Mannan
    Molecular Biology Reports.2023; 50(1): 609.     CrossRef
  • Virtual screening for chemical analogues similar to phytochemicals that inhibit aldose reductase in the development of diabetic microvascular complications
    Filex Otieno, Richard Kagia
    F1000Research.2023; 12: 314.     CrossRef
  • Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post‐hoc analysis of two randomized, placebo‐controlled trials
    Katsuhiko Hagi, Kenji Kochi, Hirotaka Watada, Kohei Kaku, Kohjiro Ueki
    Journal of Diabetes Investigation.2023; 14(9): 1101.     CrossRef
  • A FRAMEWORK FOR THE ANALYSIS OF COMORBID CONDITIONS USING INTELLIGENT EXTRACTION OF MULTIPLE FLUID BIOMARKERS
    PRIYANKA JADHAV, VINOTHINI SELVARAJU, SARITH P SATHIAN, RAMAKRISHNAN SWAMINATHAN
    Journal of Mechanics in Medicine and Biology.2023;[Epub]     CrossRef
  • Determinants of Hypertension Among Patients with Diabetes mellitus in Public Hospitals of Kembata Tambaro Zone, South Nations Nationalities and Peoples Region, Ethiopia, 2021; A Case Control Study
    Yeshialem Kenore, Solomon Abrha, Amanuel Yosef, Temesgen Bati Gelgelu
    Journal of Multidisciplinary Healthcare.2022; Volume 15: 2141.     CrossRef
  • The Magnitude of Diabetes Mellitus in Adult Hypertensive Patients in Northeast Ethiopia
    Mekuriaw Wuhib Shumye, Belachew Tegegne, Sewunet Ademe, Moges Workneh, Million Abera, Gugsa Nemera, Fikadu Balcha
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 37.     CrossRef
  • Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus
    Rujikorn Rattanatham, Nongnuch Settasatian, Nantarat Komanasin, Upa Kukongviriyapan, Kittisak Sawanyawisuth, Phongsak Intharaphet, Vichai Senthong, Chatri Settasatian
    Diabetes & Metabolism Journal.2021; 45(4): 578.     CrossRef
  • Determinants of hypertension among patients with type 2 diabetes mellitus on follow-up at Tikur Anbessa Specialized Hospital, Addis Ababa: A case-control study
    Kehabtimer Shiferaw Kotiso, Nabiha Degemu, Samson Gebremedhin, Melaku Taye, Adane Petros, Fanuel Belayneh, Deneke Wolde, Dejene Hailu, Yoshihiro Fukumoto
    PLOS ONE.2021; 16(8): e0256399.     CrossRef
  • Blood Pressure and Cardiovascular Disease in Older Patients With Diabetes: Retrospective Cohort Study
    Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • The role of text messaging intervention in Inner Mongolia among patients with type 2 diabetes mellitus: a randomized controlled trial
    Xuemei Wang, Dan Liu, Maolin Du, Ruiqi Hao, Huiqiu Zheng, Chaoli Yan
    BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
  • Nomogram for the prediction of diabetic nephropathy risk among patients with type 2 diabetes mellitus based on a questionnaire and biochemical indicators: a retrospective study
    Yuhong Hu, Rong Shi, Ruohui Mo, Fan Hu
    Aging.2020; 12(11): 10317.     CrossRef
  • Magnitude and determinants of drug therapy problems among type 2 diabetes mellitus patients with hypertension in Ethiopia
    Belayneh Kefale, Gobezie T Tegegne, Yitayih Kefale, Mulugeta Molla, Amien Ewunetei, Amsalu Degu
    SAGE Open Medicine.2020; 8: 205031212095469.     CrossRef
  • Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
    Martijn Hoevenaar, Dolf Goossens, Janne Roorda
    Journal of the Renin-Angiotensin-Aldosterone System.2020; 21(4): 147032032097909.     CrossRef
  • Impact of diabetes self-management, diabetes management self-efficacy and diabetes knowledge on glycemic control in people with Type 2 Diabetes (T2D): A multi-center study in Thailand
    Cameron P. Hurst, Nitchamon Rakkapao, Karen Hay, Chung-Ying Lin
    PLOS ONE.2020; 15(12): e0244692.     CrossRef
  • An evaluation of the impact of aggressive hypertension, diabetes and smoking cessation management on CVD outcomes at the population level: a dynamic simulation analysis
    John Pastor Ansah, Ryan Leung Hoe Inn, Salman Ahmad
    BMC Public Health.2019;[Epub]     CrossRef
  • Association between socioeconomic status and prevalence of non-communicable diseases risk factors and comorbidities in Bangladesh: findings from a nationwide cross-sectional survey
    Tuhin Biswas, Nick Townsend, Md Saimul Islam, Md Rajibul Islam, Rajat Das Gupta, Sumon Kumar Das, Abdullah Al Mamun
    BMJ Open.2019; 9(3): e025538.     CrossRef
  • Risk factors for diabetic nephropathy complications in community patients with type 2 diabetes mellitus in Shanghai: Logistic regression and classification tree model analysis
    Jieqiong Lou, Limei Jing, Hui Yang, Fei Qin, Wen Long, Rong Shi
    The International Journal of Health Planning and Management.2019; 34(3): 1013.     CrossRef
  • Retinopathy among Chinese subjects with type 2 diabetes mellitus in Shanghai: A community‐based follow‐up study
    Fei Qin, Limei Jing, Lili Jia, Jieqiong Lou, Yi Feng, Wen Long, Hui Yang, Rong Shi
    The International Journal of Health Planning and Management.2019; 34(3): 998.     CrossRef
  • Prevalence of Microvascular Complications in Type 2 Diabetics Attending a Primary Healthcare Centre in Sudan
    Mustafa Hussein, Sami Menasri
    Dubai Diabetes and Endocrinology Journal.2019; 25(3-4): 127.     CrossRef
  • Assessment of drug related problems among type 2 diabetes mellitus patients with hypertension in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia
    Yohanes Ayele, Kibkab Melaku, Mesay Dechasa, Mohammed Biset Ayalew, Boressa Adugna Horsa
    BMC Research Notes.2018;[Epub]     CrossRef
  • Neurosurgical position causes peripheral nerve injuries?
    Pedro Esquivel-Enríquez, Iván Pérez-Neri, Luisa Manrique-Carmona
    Cirugía y Cirujanos (English Edition).2017; 85(6): 493.     CrossRef
  • ¿La posición neuroquirúrgica ocasiona lesión de nervio periférico?
    Pedro Esquivel-Enríquez, Iván Pérez-Neri, Luisa Manrique-Carmona
    Cirugía y Cirujanos.2017; 85(6): 493.     CrossRef
Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients
Hye-Jin Yoon, Youn-Zoo Cho, Ji-young Kim, Byung-Joon Kim, Keun-Young Park, Gwan-Pyo Koh, Dae-Ho Lee, Dong-Mee Lim
Diabetes Metab J. 2012;36(5):379-387.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.379
  • 6,347 View
  • 44 Download
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM).

Methods

A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed.

Results

In patients with retinopathy, basal C-peptide was 1.9±1.2 ng/mL, and stimulated C-peptide was 2.7±1.6 ng/mL; values were significantly lower compared with patients without retinopathy (P=0.031 and P=0.002, respectively). In patients with nephropathy, basal C-peptide was 1.6±0.9 ng/mL, and stimulated C-peptide was 2.8±1.6 ng/mL; values were significantly lower than those recorded in patients without nephropathy (P=0.020 and P=0.026, respectively). Stimulated C-peptide level was associated with increased prevalence of microvascular complications. Age-, DM duration-, and hemoglobin A1c-adjusted odds ratios for retinopathy in stimulated C-peptide value were 4.18 (95% confidence interval [CI], 1.40 to 12.51) and 3.35 (95% CI, 1.09 to 10.25), respectively. The multiple regression analysis between nephropathy and C-peptide showed that stimulated C-peptide was statistically correlated with nephropathy (P=0.03).

Conclusion

In patients with type 2 diabetes, the glucagon stimulation test was a relatively simple method of short duration for stimulating C-peptide response. Stimulated C-peptide values were associated with microvascular complications to a greater extent than basal C-peptides.

Citations

Citations to this article as recorded by  
  • A Nomogram for Predicting Vision-Threatening Diabetic Retinopathy Among Mild Diabetic Retinopathy Patients: A Case–Control and Prospective Study of Type 2 Diabetes
    Jing Ke, Kun Li, Bin Cao
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 275.     CrossRef
  • The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study
    Ting Pan, Jie Gao, Xinghua Cai, Huihui Zhang, Jun Lu, Tao Lei
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Dysregulation of miR-374a is involved in the progression of diabetic retinopathy and regulates the proliferation and migration of retinal microvascular endothelial cells
    Zhanhong Wang, Xiao Zhang, Yanjun Wang, Dailing Xiao
    Clinical and Experimental Optometry.2022; 105(3): 287.     CrossRef
  • The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey
    Hye Eun Cho, Seung Bum Yang, Mi Young Gi, Ju Ae Cha, so Young Park, Hyun Yoon
    Endocrine Research.2022; 47(2): 80.     CrossRef
  • Effects of Serum C-Peptide Level on Blood Lipid and Cardiovascular and Cerebrovascular Injury in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis
    Juan Qin, Rongli Sun, Ding Ding, Yuvaraja Teekaraman
    Contrast Media & Molecular Imaging.2022; 2022: 1.     CrossRef
  • Investigation of Diabetes Complication Risk Perception and Diabetes Self-Management Skills in Individuals with Diabetes
    Mehmet AYTEMUR, Bahar İNKAYA
    Turkish Journal of Diabetes and Obesity.2022; 6(2): 121.     CrossRef
  • Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness
    Eli Ipp
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association of C-peptide with diabetic vascular complications in type 2 diabetes
    Y. Wang, H. Wan, Y. Chen, F. Xia, W. Zhang, C. Wang, S. Fang, K. Zhang, Q. Li, N. Wang, Y. Lu
    Diabetes & Metabolism.2020; 46(1): 33.     CrossRef
  • Variations in glucose/C-peptide ratio in patients with type 2 diabetes associated with renal function
    John A. D'Elia, Christopher Mulla, Jiankang Liu, Larry A. Weinrauch
    Diabetes Research and Clinical Practice.2019; 150: 1.     CrossRef
  • The pharmacokinetics of porcine C‐peptide after intraperitoneal injection
    Naho Iizuka, Masuhiro Nishimura, Yasutaka Fujita, Osamu Sawamoto, Shinichi Matsumoto
    Xenotransplantation.2019;[Epub]     CrossRef
  • Association of KCNJ11(RS5219) gene polymorphism with biochemical markers of glycemic status and insulin resistance in gestational diabetes mellitus
    Lenin M, Ramesh Ramasamy, Sweta Kulkarani, Seetesh Ghose, Srinivasan A.R.S., Sathish Babu M
    Meta Gene.2018; 16: 134.     CrossRef
  • Glucagon secretion is increased in patients with Type 2 diabetic nephropathy
    Xiaoyu Wang, Juhong Yang, Baocheng Chang, Chunyan Shan, Yanguang Xu, Miaoyan Zheng, Ying Wang, Huizhu Ren, Liming Chen
    Journal of Diabetes and its Complications.2016; 30(3): 488.     CrossRef
  • Relationship between serum C-peptide level and diabetic retinopathy according to estimated glomerular filtration rate in patients with type 2 diabetes
    Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
    Journal of Diabetes and its Complications.2015; 29(3): 350.     CrossRef
  • Independent association between serum C‐peptide levels and fat mass‐to‐lean mass ratio in the aging process
    Ying Li, Lian Shun Zheng, Yue Li, Duo Duo Zhao, Lu Meng
    Geriatrics & Gerontology International.2015; 15(7): 918.     CrossRef
  • Relationship Between β-Cell Function, Metabolic Control, and Microvascular Complications in Type 2 Diabetes Mellitus
    Lihua Zhao, Jing Ma, Shaoxin Wang, Yun Xie
    Diabetes Technology & Therapeutics.2015; 17(1): 29.     CrossRef
  • Association of fasting insulin and C peptide with diabetic retinopathy in Latinos with type 2 diabetes
    Jane Z Kuo, Xiuqing Guo, Ronald Klein, Barbara E Klein, Robert N Weinreb, Pauline Genter, Fone-Ching Hsiao, Mark O Goodarzi, Jerome I Rotter, Yii-Der Ida Chen, Eli Ipp
    BMJ Open Diabetes Research & Care.2014; 2(1): e000027.     CrossRef
  • Association between physical activity and serum C‐peptide levels among the elderly
    Ying Li, Lu Meng, QianQian Miao, Yasuto Sato
    Geriatrics & Gerontology International.2014; 14(3): 647.     CrossRef
  • Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese
    Xiaoling Cai, Xueyao Han, Simin Zhang, Yingying Luo, Yingli Chen, Linong Ji, Alfred S. Lewin
    PLoS ONE.2014; 9(3): e91174.     CrossRef
  • Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset Type 1 and Type 2 Diabetes
    Ramachandran Rajalakshmi, Anandakumar Amutha, Harish Ranjani, Mohammed K. Ali, Ranjit Unnikrishnan, Ranjit Mohan Anjana, K.M. Venkat Narayan, Viswanathan Mohan
    Journal of Diabetes and its Complications.2014; 28(3): 291.     CrossRef
  • Prediction of response to GLP-1 receptor agonist therapy in Japanese patients with type 2 diabetes
    Kenjiro Imai, Tetsuro Tsujimoto, Atsushi Goto, Maki Goto, Miyako Kishimoto, Ritsuko Yamamoto-Honda, Hiroshi Noto, Hiroshi Kajio, Mitsuhiko Noda
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
  • The Association between the Serum C-Peptide Level and Bone Mineral Density
    Ying Li, Hua Liu, Yasuto Sato, Bin He
    PLoS ONE.2013; 8(12): e83107.     CrossRef
  • C-Peptide and Its Career from Innocent Bystander to Active Player in Diabetic Atherogenesis
    Corinna Lebherz, Nikolaus Marx
    Current Atherosclerosis Reports.2013;[Epub]     CrossRef
  • C-Peptide and Vascular Complications in Type 2 Diabetic Subjects
    Seok Man Son
    Diabetes & Metabolism Journal.2012; 36(5): 345.     CrossRef
Reviews
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Seok Man Son
Diabetes Metab J. 2012;36(3):190-198.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.190
  • 5,500 View
  • 59 Download
  • 83 Crossref
AbstractAbstract PDFPubReader   

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

Citations

Citations to this article as recorded by  
  • Relationship of phytochemicals and antioxidant activities in Gymnema inodorum leaf extracts
    Onanong Nuchuchua, Wanwisa Srinuanchai, Chaisak Chansriniyom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Nitra Nuengchamnong, Uracha Ruktanonchai
    Heliyon.2024; 10(1): e23175.     CrossRef
  • The Role of Glutathione and Its Precursors in Type 2 Diabetes
    Dawn Tuell, George Ford, Evan Los, William Stone
    Antioxidants.2024; 13(2): 184.     CrossRef
  • Combined toxicity of microplastics and copper on Goniopora columns
    Ya-Ting Chen, De-Sing Ding, Yee Cheng Lim, Cheng-Di Dong, Shu-Ling Hsieh
    Environmental Pollution.2024; 345: 123515.     CrossRef
  • Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics
    Divinah Manoharan, Liu‐Chun Wang, Ying‐Chi Chen, Wei‐Peng Li, Chen‐Sheng Yeh
    Advanced Healthcare Materials.2024;[Epub]     CrossRef
  • Oxidative Stress, Endothelial Dysfunction, and N-Acetylcysteine in Type 2 Diabetes Mellitus
    Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
    Antioxidants & Redox Signaling.2024; 40(16-18): 968.     CrossRef
  • Acacia gum: Chemistry, properties & food applications
    Deepak Mudgil, Sheweta Mudgil
    Food and Humanity.2024; 2: 100264.     CrossRef
  • High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
    Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
    Life Sciences.2023; 312: 121208.     CrossRef
  • Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
    Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
    Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
    Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
    Aquaculture Research.2023; 2023: 1.     CrossRef
  • Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
    Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
    Cells.2023; 12(4): 583.     CrossRef
  • In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
    Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
    Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
  • Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
    Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
    Biochimie.2022; 195: 114.     CrossRef
  • Effects of Smoking on Diabetic Nephropathy
    Yasemin Gündoğdu, İnan Anaforoğlu
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
    Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
    Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
    Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
  • Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
    Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
    Aquatic Toxicology.2022; 250: 106259.     CrossRef
  • “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
    Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
  • Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
    Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
    Molecules.2022; 27(22): 8043.     CrossRef
  • p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
    Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
    Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
  • Elucidation of phytochemicals and antioxidants properties of Sasa quelpaertensis
    Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
    International Journal of Food Properties.2021; 24(1): 210.     CrossRef
  • Organelle dynamics of endothelial mitochondria in diabetic angiopathy
    Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
    European Journal of Pharmacology.2021; 895: 173865.     CrossRef
  • Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
    Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
    Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
    Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
  • NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
    Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
    Cells.2021; 10(2): 314.     CrossRef
  • Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
    Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
    Sweta Pal, G. Nageswar Rao, Arttatrana Pal
    Life Sciences.2021; 279: 119693.     CrossRef
  • The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
    Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
    Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
  • The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
    V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
    Cytology and Genetics.2021; 55(4): 331.     CrossRef
  • Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
    Hollie Speer, Andrew J. McKune
    Antioxidants.2021; 10(8): 1247.     CrossRef
  • Natural Antioxidants in New Age-Related Diseases
    Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
    Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
  • Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
    Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
    Obesity Medicine.2020; 19: 100274.     CrossRef
  • Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
    Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
    Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
  • Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
    Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
    Industrial Crops and Products.2020; 146: 112158.     CrossRef
  • Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
    Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Heme on Pulmonary Malaria: Friend or Foe?
    Tatiana Almeida Pádua, Mariana Conceição Souza
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
    Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
    Experimental Eye Research.2020; 201: 108255.     CrossRef
  • The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
    Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
    Nutrients.2020; 12(7): 2108.     CrossRef
  • Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
    Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
    Antioxidants.2020; 9(6): 491.     CrossRef
  • Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
    Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
  • Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
    M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
    Surfaces and Interfaces.2020; 19: 100540.     CrossRef
  • The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
    Sheetal Panday, Raghav Talreja, Mahendra Kavdia
    Microvascular Research.2020; 131: 104010.     CrossRef
  • Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
    V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
    Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
  • Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
    Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
    Frontiers in Veterinary Science.2020;[Epub]     CrossRef
  • Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
    Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
  • Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
    J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
    Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
  • Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
    Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • The impact of xanthine oxidase (XO) on hemolytic diseases
    Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
    Redox Biology.2019; 21: 101072.     CrossRef
  • What is responsible for antioxidant properties of polyphenolic compounds from plants?
    Małgorzata Olszowy
    Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
  • Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
    Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
    Cells.2019; 8(5): 464.     CrossRef
  • Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
    Xiaojuan Yang, Jing Song, Liang-Jun Yan
    Antioxidants.2019; 8(2): 32.     CrossRef
  • Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
    Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
    Current Eye Research.2019; 44(3): 294.     CrossRef
  • Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
    Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
    Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
    Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
    Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
  • Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
    Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
    Reproductive Sciences.2018; 25(11): 1531.     CrossRef
  • Nutrients and Oxidative Stress: Friend or Foe?
    Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
    Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • An Update on Hypertension in Children With Type 1 Diabetes
    Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
    Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
  • Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
    Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
    Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
    Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
  • Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
    Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
    Food Research International.2017; 95: 117.     CrossRef
  • Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
    Veerappan Ramanathan, Malarvili Thekkumala
    Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
  • Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
    Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
    Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
  • Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
    Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
    BioImpacts.2017; 7(4): 219.     CrossRef
  • The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
    Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
    The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
  • Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
    Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
    Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
    Aging and disease.2016; 7(1): 90.     CrossRef
  • İNSAN VE HAYVANLARDA DİABETES MELLİTUS
    Özlem ÖZMEN, Senay TOPSAKAL
    Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
  • The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
    Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
    Pharmacological Research.2016; 113: 186.     CrossRef
  • Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
    Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
    Food Chemistry.2016; 201: 315.     CrossRef
  • Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
    Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
    Endocrine.2015; 50(2): 405.     CrossRef
  • Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
    Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
    International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
  • Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
    L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
    British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
  • Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
    Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
    Pathophysiology.2015; 22(4): 189.     CrossRef
  • Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
    J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
    Oral Diseases.2015; 21(5): 634.     CrossRef
  • Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
    Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
    PLOS ONE.2015; 10(4): e0123987.     CrossRef
  • Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
    Abeer Hanafy, Jihan M. Badr
    Natural Product Research.2014; 28(24): 2351.     CrossRef
  • Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
    TM Boĭchuk, TP Savchuk
    Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
  • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    Paulo Zoé Costa, Raquel Soares
    Life Sciences.2013; 92(22): 1037.     CrossRef
  • Oxidative-stress-induced epigenetic changes in chronic diabetic complications
    Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
    Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
  • Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
    Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
    Archives of Medical Research.2013; 44(7): 514.     CrossRef
  • Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
    Daye Cheng, Bin Liang, Yunhui Li
    BioMed Research International.2013; 2013: 1.     CrossRef
Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
Diabetes Metab J. 2011;35(6):571-577.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.571
  • 63,574 View
  • 63 Download
  • 34 Crossref
AbstractAbstract PDFPubReader   

The prevalence of diabetes in Korea has increased six- to sevenfold over the past 40 years with its complications becoming major causes of morbidity and mortality. The rate of death among patients with diabetes is about twice as high as that among persons without diabetes and the most common cause of death is cardiovascular disease (30.6%). Despite the seriousness of diabetic complications, 30 to 70% of patients receive inadequate care, and only 40% of treated diabetic patients achieve the optimal control with HbA1c level <7% in Korea. In 2006, over 30 to 40% of patients with diabetes have microvascular complications and around 10% of them have macrovascular complications from our national data. Despite there are some debates about intensive glycemic control resulting in the deterioration of macrovascular complication, multifactorial treatment approaches including proper glycemic control are important to prevent diabetic complications. There have been needs for finding proper biomarkers for predicting diabetic complications properly but we still need more longitudinal studies to find this correlation with causal relationship. In this article, we wanted to review the recent status of micro- and macrovascular complications of type 2 diabetes in Korea from integration of many epidemiologic studies.

Citations

Citations to this article as recorded by  
  • Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
    Jonnell C. Small, Aidan Joblin-Mills, Kaycee Carbone, Maria Kost-Alimova, Kumiko Ayukawa, Carol Khodier, Vlado Dancik, Paul A. Clemons, Andrew B. Munkacsi, Bridget K. Wagner
    ACS Chemical Biology.2022; 17(5): 1131.     CrossRef
  • Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea
    Hye Soon Kim, Jae Myung Yu, Hak Chul Jang, Eui Kwang Choi, Jeong Hyun Park, Ho Sang Shon, Choon Hee Chung, Keun-Gyu Park, Jae Hyoung Cho, Won Kim, Kyoung Hwa Lee, Jee Hyun Lee, Soon Jib Yoo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1495.     CrossRef
  • Validity of the diagnosis of diabetic microvascular complications in Korean national health insurance claim data
    Hyung Jun Kim, Moo-Seok Park, Jee-Eun Kim, Tae-Jin Song
    Annals of Clinical Neurophysiology.2022; 24(1): 7.     CrossRef
  • Effects of Jerusalem Artichoke Extract and Inulin on Blood Glucose Levels and Insulin Secretion in Streptozotocin Induced Diabetic Mice
    Seung Hee Kim, Byung Ki Kim, Boo Yeun Park, Jung Min Kim, Young Jik Lee, Mi Kyung Lee, Sung-Tae Yee, Mi Yeon Kang
    The Journal of Korean Diabetes.2021; 22(1): 60.     CrossRef
  • Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim
    Diabetes & Metabolism Journal.2020; 44(6): 928.     CrossRef
  • A prospective cohort study on effects of gemigliptin on cardiovascular outcomes in patients with type 2 diabetes (OPTIMUS study)
    Eun Heui Kim, Sang Soo Kim, Dong Jun Kim, Young Sik Choi, Chang Won Lee, Bon Jeong Ku, Kwang Soo Cha, Kee Ho Song, Dae Kyeong Kim, In Joo Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea
    Kyoung Hwa Ha, Bongseong Kim, Hae Sol Shin, Jinhee Lee, Hansol Choi, Hyeon Chang Kim, Dae Jung Kim
    Korean Circulation Journal.2018; 48(5): 395.     CrossRef
  • High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
    Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte
    Salih Awla Hamzah, Luqman Awla Hamza, Heshu Sulaman Rahman
    Kurdistan Journal of Applied Research.2018; 3(1): 58.     CrossRef
  • Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
    Giorgia Pierelli, Rosita Stanzione, Maurizio Forte, Serena Migliarino, Marika Perelli, Massimo Volpe, Speranza Rubattu
    Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
  • Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association
    Hyun Jin Kim, Seok O Park, Seung-Hyun Ko, Sang Youl Rhee, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Byung-Wan Lee, Jin Hwa Kim, Kyung Mook Choi
    Diabetes & Metabolism Journal.2017; 41(6): 423.     CrossRef
  • Management of Hypertension in Diabetic Patients
    Sang Yong Kim
    The Journal of Korean Diabetes.2016; 17(2): 88.     CrossRef
  • Cardiovascular Autonomic Dysfunction Predicts Diabetic Foot Ulcers in Patients With Type 2 Diabetes Without Diabetic Polyneuropathy
    Jae-Seung Yun, Seon-Ah Cha, Tae-Seok Lim, Eun-Young Lee, Ki-Ho Song, Yu-Bae Ahn, Ki-Dong Yoo, Joon-Sung Kim, Yong-Moon Park, Seung-Hyun Ko
    Medicine.2016; 95(12): e3128.     CrossRef
  • Obesity and Insulin Resistance According to Age in Newly Diagnosed Type 2 Diabetes Patients in Korea
    Ju Won Lee, Nam Kyu Kim, Hyun Joon Park, Jun Yeob Lee, Seon Yoon Choi, Eun Mi Lee, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
    Kosin Medical Journal.2016; 31(2): 157.     CrossRef
  • Exercise is associated with metabolism regulation and complications in Korean patients with type 2 diabetes
    Jin-Won Noh, Jeong Eun Park, Jin Hee Jung, Jung Hwa Lee, Kang Hee Sim, Min Hee Kim
    Journal of Physical Therapy Science.2015; 27(7): 2189.     CrossRef
  • Diabetes in Asians
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
  • Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
    Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
    The Diabetes Educator.2015; 41(2): 203.     CrossRef
  • Association of adiponectin polymorphisms with the risk of diabetic nephropathy in type 2 diabetes: A meta‐analysis 脂联素基因多态性与2型糖尿病肾病的相关性:一项meta分析
    Yuli Cai, Tianshu Zeng, Lulu Chen
    Journal of Diabetes.2015; 7(1): 31.     CrossRef
  • Association between the extent of urinary albumin excretion and glycaemic variability indices measured by continuous glucose monitoring
    S.‐M. Jin, T.‐H. Kim, S. Oh, J. Baek, J. Y. Joung, S.‐M. Park, Y. Y. Cho, S. Y. Sohn, K. Y. Hur, M.‐S. Lee, M.‐K. Lee, J. H. Kim
    Diabetic Medicine.2015; 32(2): 274.     CrossRef
  • Association Between Heme Oxygenase-1 Promoter Polymorphisms and the Development of Albuminuria in Type 2 Diabetes
    Eun Young Lee, Yong-ho Lee, Soo Hyun Kim, Kyu Sik Jung, Obin Kwon, Beom Seok Kim, Chung Mo Nam, Chun Sik Park, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee
    Medicine.2015; 94(43): e1825.     CrossRef
  • Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
    Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
    Diabetes & Metabolism Journal.2015; 39(4): 307.     CrossRef
  • Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?
    Akanksha Gupta, Sonika Bhatnagar
    OMICS: A Journal of Integrative Biology.2015; 19(12): 733.     CrossRef
  • Assessment of glycemic control in patients with type 2 diabetes mellitus treated with metformin–sulfonylurea combination: Results of a multicenter, cross‐sectional, observational study in Korea
    Sin Gon Kim, Jong Ryeal Hahm, Duk Kyu Kim, Sung Rae Cho, Dong Seop Choi
    Journal of Diabetes Investigation.2015; 6(3): 317.     CrossRef
  • Sleep Duration and Glycemic Control in Patients with Diabetes Mellitus: Korea National Health and Nutrition Examination Survey 2007-2010
    Bu Kyung Kim, Bong Sun Kim, So-Yeon An, Min Suk Lee, Yong Jun Choi, Seung Jin Han, Yoon-sok Chung, Kwan-Woo Lee, Dae Jung Kim
    Journal of Korean Medical Science.2013; 28(9): 1334.     CrossRef
  • Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes
    Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Ihn-Ho Cho, Hyoung Woo Lee
    Diabetes & Metabolism Journal.2013; 37(1): 54.     CrossRef
  • Prevalence and factors associated with diabetic retinopathy in a Korean adult population: The 2008–2009 Korea National Health and Nutrition Examination Survey
    Ju Yean Yang, Na Kyung Kim, Yun Jeong Lee, Jung Hyun Noh, Dae Jung Kim, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
    Diabetes Research and Clinical Practice.2013; 102(3): 218.     CrossRef
  • Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and Risk of Diabetic Microvascular Complications: A Meta-Analysis
    Xianghui Su, Xi Chen, Lei Liu, Xiangyun Chang, Xuefeng Yu, Kan Sun, Rudolf Kirchmair
    PLoS ONE.2013; 8(7): e69940.     CrossRef
  • Variants of the Adiponectin Gene and Diabetic Microvascular Complications in Patients with Type 2 Diabetes
    Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Kwang Joon Kim, Bum Seok Kim, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang, Christos S. Mantzoros
    Metabolism.2013; 62(5): 677.     CrossRef
  • Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension
    Dong Il Shin, Ki-Bae Seung, Hye Eun Yoon, Byung-Hee Hwang, Suk Min Seo, Seok Joon Shin, Pum-Joon Kim, Kiyuk Chang, Sang Hong Baek
    Journal of Korean Medical Science.2013; 28(2): 252.     CrossRef
  • Comparison of Two Creatinine-Based Equations for Predicting Decline in Renal Function in Type 2 Diabetic Patients with Nephropathy in a Korean Population
    Eun Young Lee, Young-Mi Lee, Kyu Hun Choi, Hyun Chul Lee, Byung-Wan Lee, Beom Seok Kim
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Physical Fitness in Children with Type 1 Diabetes Measured with Six-Minute Walk Test
    Vladimir Jegdic, Zeljko Roncevic, Veselin Skrabic
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Long-term changes of the prevalence and control rate of hypertension among Korean adults with diagnosed diabetes: 1998–2008 Korean National Health and Nutrition Examination Survey
    Seung-Hyun Ko, Hyuk-Sang Kwon, Ki-Ho Song, Yu-Bae Ahn, Kun-Ho Yoon, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park
    Diabetes Research and Clinical Practice.2012; 97(1): 151.     CrossRef
  • Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography
    Sanghoon Shin, Kwang-Joon Kim, Hyuk-Jae Chang, Iksung Cho, Young Jin Kim, Byoung-Wook Choi, Yumie Rhee, Sung-Kil Lim, Woo-In Yang, Chi-Young Shim, Jong-Won Ha, Yangsoo Jang, Namsik Chung
    European Heart Journal.2012; 33(22): 2873.     CrossRef
  • Contributions of diabetic macro-vascular complications and hip fracture to depression onset in elderly patients with diabetes: An 8-year population-based follow-up study
    Hsueh-Hsing Pan, Chung-Yi Li, Pei-Chun Chen, Ming-Der Lee, Chun-Yu Liang, Wen-Hsuan Hou, Kwua-Yun Wang
    Journal of Psychosomatic Research.2012; 73(3): 180.     CrossRef
New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia
In-Kyung Jeong, George L. King
Diabetes Metab J. 2011;35(1):8-11.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.8
  • 6,466 View
  • 35 Download
  • 24 Crossref
AbstractAbstract PDFPubReader   

Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications via the formation of toxic metabolites such as oxidative stress, advanced glycosylated end products, persistent activation of protein kinase C, and increased sorbitol concentrations. However, vascular complications result from imbalances caused by increases in systemic toxic metabolites, such as those that occur under conditions of hyperglycemia and dyslipidemia, and by reductions in endogenous protective factors such as insulin, vascular endothelial growth factor, and platelet derived growth factor. This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors.

Citations

Citations to this article as recorded by  
  • Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases
    Adriana Grismaldo, Luis Sobrevia, Ludis Morales
    Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(10): 130188.     CrossRef
  • Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis
    Yue Li, Ke Wang, Xue Zhu, Zhengqi Cheng, Ling Zhu, Michael Murray, Fanfan Zhou
    Journal of Pharmacy and Pharmacology.2022;[Epub]     CrossRef
  • Organic Isothiocyanates as Hydrogen Sulfide Donors
    Alma Martelli, Valentina Citi, Lara Testai, Simone Brogi, Vincenzo Calderone
    Antioxidants & Redox Signaling.2020; 32(2): 110.     CrossRef
  • PGC‐1α, a potential therapeutic target against kidney aging
    Gayoung Lee, Md Jamal Uddin, Yoojeong Kim, Minji Ko, Inyoung Yu, Hunjoo Ha
    Aging Cell.2019;[Epub]     CrossRef
  • Glucometabolic characteristics and higher vascular complication risk in Korean patients with type 2 diabetes with non-albumin proteinuria
    Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-wan Lee
    Journal of Diabetes and its Complications.2019; 33(8): 585.     CrossRef
  • Ameliorative effects of taurine against diabetes: a review
    Inam-u-llah, Fengyuan Piao, Rana Muhammad Aadil, Raheel Suleman, Kaixin Li, Mengren Zhang, Pingan Wu, Muhammad Shahbaz, Zulfiqar Ahmed
    Amino Acids.2018; 50(5): 487.     CrossRef
  • Notoginsenoside Fc attenuates high glucose-induced vascular endothelial cell injury via upregulation of PPAR-γ in diabetic Sprague–Dawley rats
    Jingjing Liu, Chunyu Jiang, Xu Ma, Jianbo Wang
    Vascular Pharmacology.2018; 109: 27.     CrossRef
  • Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway
    YAN SUN, CAIMEI XIU, WEI LIU, YUAN TAO, JIANRONG WANG, YI QU
    Experimental and Therapeutic Medicine.2016; 11(4): 1253.     CrossRef
  • Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway
    Wensong Zhang, Yi Li, Hanlu Ding, Yaqin Du, Li Wang
    Renal Failure.2016; 38(7): 1099.     CrossRef
  • TNFSF15 Inhibits Blood Retinal Barrier Breakdown Induced by Diabetes
    Feng Jiang, Qingzhong Chen, Liming Huang, Ying Wang, Zhuhong Zhang, Xiangda Meng, Yuanyuan Liu, Chunjie Mao, Fang Zheng, Jingkai Zhang, Hua Yan
    International Journal of Molecular Sciences.2016; 17(5): 615.     CrossRef
  • Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
    Sanghoon Shin, Kwang-Joon Kim, In-Jeong Cho, Geu-Ru Hong, Yangsoo Jang, Namsik Chung, Young Min Rah, Hyuk-Jae Chang
    Yonsei Medical Journal.2015; 56(5): 1227.     CrossRef
  • NRF2 plays a protective role in diabetic retinopathy in mice
    Zhenhua Xu, Yanhong Wei, Junsong Gong, Hongkwan Cho, James K. Park, Ee-Rah Sung, Hu Huang, Lijuan Wu, Charles Eberhart, James T. Handa, Yunpeng Du, Timothy S. Kern, Rajesh Thimmulappa, Alistair J. Barber, Shyam Biswal, Elia J. Duh
    Diabetologia.2014; 57(1): 204.     CrossRef
  • Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ‐induced diabetes
    Yucheng Liu, Yonggang Wang, Xiao Miao, Shanshan Zhou, Yi Tan, Guang Liang, Yang Zheng, Quan Liu, Jian Sun, Lu Cai
    Journal of Cellular and Molecular Medicine.2014; 18(6): 1203.     CrossRef
  • Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function
    Yonggang Wang, Zhiguo Zhang, Wanqing Sun, Yi Tan, Yucheng Liu, Yang Zheng, Quan Liu, Lu Cai, Jian Sun
    Oxidative Medicine and Cellular Longevity.2014; 2014: 1.     CrossRef
  • Therapeutic Effect of MG132 on the Aortic Oxidative Damage and Inflammatory Response in OVE26 Type 1 Diabetic Mice
    Xiao Miao, Wenpeng Cui, Weixia Sun, Ying Xin, Bo Wang, Yi Tan, Lu Cai, Lining Miao, Yaowen Fu, Guanfang Su, Yuehui Wang
    Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
  • Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
    Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
    Diabetes & Metabolism Journal.2013; 37(5): 365.     CrossRef
  • Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
    Susana Siewert, Irma González, Lucas Santillán, Roberto Lucero, Marta S. Ojeda, María S. Gimenez
    Journal of Diabetes Mellitus.2013; 03(02): 71.     CrossRef
  • The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double‐blind, randomized, controlled trial
    S. Shin, K. J. Kim, H. ‐J. Chang, B. ‐W. Lee, W. ‐I. Yang, B. ‐S. Cha, D. Choi
    Diabetes, Obesity and Metabolism.2013; 15(2): 185.     CrossRef
  • Areca nut procyanidins ameliorate streptozocin-induced hyperglycemia by regulating gluconeogenesis
    Pei-Ling Huang, Chin-Wen Chi, Tsung-Yun Liu
    Food and Chemical Toxicology.2013; 55: 137.     CrossRef
  • Serum glycated albumin predicts the progression of carotid arterial atherosclerosis
    Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
    Atherosclerosis.2012; 225(2): 450.     CrossRef
  • Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants
    Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su, Lu Cai
    Nutrition & Metabolism.2012;[Epub]     CrossRef
  • Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients
    Hyun Min Kim, Kwang Joon Kim, Jae Hoon Moon, Hye-Jeong Lee, Min Kyung Chae, Hyuk-Jae Chang, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Young Jin Kim, Byung-Wan Lee
    Acta Diabetologica.2012; 49(6): 413.     CrossRef
  • Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
    Kyoung Soo Kim, Da Hee Oh, Jung Yeon Kim, Bong Gn Lee, Jeong Soon You, Kyung Ja Chang, Hyunju Chung, Myung Chul Yoo, Hyung-In Yang, Ja-Heon Kang, Yoo Chul Hwang, Kue Jeong Ahn, Ho-Yeon Chung, In-Kyung Jeong
    Experimental & Molecular Medicine.2012; 44(11): 665.     CrossRef
  • Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
    In-Kyung Jeong, Da Hee Oh, Seung-Joon Park, Ja-Heon Kang, Sunshin Kim, Myung-Shik Lee, Myung-Jun Kim, Yoo-Chul Hwang, Kyu Jeong Ahn, Ho-Yeon Chung, Min-Kyung Chae, Hyung-Joon Yoo
    Experimental and Molecular Medicine.2011; 43(12): 684.     CrossRef
Original Articles
Clinical Characteristics and Direct Medical Costs of Type 2 Diabetic Patients.
Eun Joon Moon, Young Eun Jo, Tae Chin Park, Yun Kyung Kim, Sun Hye Jung, Hae Jin Kim, Dae Jung Kim, Yoon Sok Chung, Kwan Woo Lee
Korean Diabetes J. 2008;32(4):358-365.   Published online August 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.4.358
  • 2,555 View
  • 38 Download
  • 15 Crossref
AbstractAbstract PDF
BACKGROUND
Type 2 diabetes mellitus is an expensive chronic metabolic disorder and its prevalence has been increasing rapidly in South Korea, owing to a westernized lifestyle. We analyzed the annual direct medical costs attributable to type 2 diabetes and its chronic complications in Korea retrospectively. METHODS: We randomly selected 1,051 patients with type 2 diabetes who visited Ajou University Hospital as an outpatient in 2005. Clinical characteristics, duration of diabetes, and microvascular and macrovascular complications were assessed from a medical chart review. The annual direct medical costs included insurance covered and uncovered medical costs. RESULTS: Of the 1,051 patients with type 2 diabetes, 48.2% had at least one microvascular complication, 5.6% had at least one macrovascular complication, and 12.4% of the patients had both microvascular and macrovascular complications. The average annual direct medical cost was found to be 3,348,488won per patient. In patients with microvascular complications, the total cost of management was increased 1.4 times compared to those without complications. Direct medical costs for patients with macrovascular complications were 2.1-fold as high as patients with no complications. Those patients with both microvascular and macrovascular complications, increased costs by 3.1-fold over those without complications. CONCLUSION: Chronic complications have a substantial impact on the direct medical costs of type 2 diabetes. The prevention of chronic diabetic complications will not only influence the mortality and morbidity of patients with type 2 diabetes, but also potentially reduce medical costs.

Citations

Citations to this article as recorded by  
  • Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
    Morena Ustulin, Sang Youl Rhee, Suk Chon, Kyu Keung Ahn, Ji Eun Lim, Bermseok Oh, Sung-Hoon Kim, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Young Seol Kim, Jeong-Taek Woo
    Scientific Reports.2018;[Epub]     CrossRef
  • Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data
    Sejeong Park, Sang Youl Rhee, Su Jin Jeong, Kiyoung Kim, Suk Chon, Seung-Young Yu, Jeong-Taek Woo
    Diabetes & Metabolism Journal.2017; 41(5): 393.     CrossRef
  • Association between Sleep Duration and Impaired Fasting Glucose in Korean Adults: Results from the Korean National Health and Nutrition Examination Survey 2011–2012
    Cho-Rong Kim, Yun-Mi Song, Jin-Young Shin, Wook Gim
    Korean Journal of Family Medicine.2016; 37(1): 51.     CrossRef
  • Trends in the Diabetes Epidemic in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    Endocrinology and Metabolism.2015; 30(2): 142.     CrossRef
  • Economic Evaluation of Diabetes Education
    Jin-Won Noh, Young Dae Kwon, Jin-Hee Jung, Kang Hee Sim, Hee-Sook Kim, Minjae Choi, Jumin Park
    The Journal of Korean Diabetes.2015; 16(4): 293.     CrossRef
  • Association between diabetes-related factors and clinical periodontal parameters in type-2 diabetes mellitus
    Eun-Kyong Kim, Sang Gyu Lee, Youn-Hee Choi, Kyu-Chang Won, Jun Sung Moon, Anwar T Merchant, Hee-Kyung Lee
    BMC Oral Health.2013;[Epub]     CrossRef
  • Cytoprotective Effect of Ethanol Extract from Maesil (Prunus mume Sieb. et Zucc.) on Alloxan-induced Oxidative Damage in Pancreatic-cell, HIT-T15
    In-Hye Kim, Jong-Bae Kim, Kang-Jin Cho, Jae-Hyun Kim, Ae-Son Om
    Korean Journal of Plant Resources.2012; 25(2): 184.     CrossRef
  • The Protective Effects of Chrysanthemum cornarium L. var. spatiosum Extract on HIT-T15 Pancreatic β-Cells against Alloxan-induced Oxidative Stress
    In-Hye Kim, Kang-Jin Cho, Jeong-Sook Ko, Jae-Hyun Kim, Ae-Son Om
    The Korean Journal of Food And Nutrition.2012; 25(1): 123.     CrossRef
  • Outcome Research in Diabetes
    Kwan Woo Lee
    Journal of Korean Diabetes.2011; 12(1): 2.     CrossRef
  • Costs of Diabetes Mellitus in Korea
    Kwan Woo Lee
    Diabetes & Metabolism Journal.2011; 35(6): 567.     CrossRef
  • The Epidemiology of Diabetes in Korea
    Dae Jung Kim
    Diabetes & Metabolism Journal.2011; 35(4): 303.     CrossRef
  • The Hypoglycemic Effect of Complex of Chinese Traditional Herbs (CTH) and Macelignan in Type 2 Diabetic Animal Model

    Journal of Life Science.2010; 20(7): 1113.     CrossRef
  • Epidemiologic Characteristics of Diabetes Mellitus in Korea: Current Status of Diabetic Patients Using Korean Health Insurance Database
    Ie Byung Park, Sei Hyun Baik
    Korean Diabetes Journal.2009; 33(5): 357.     CrossRef
  • Management of Diabetic Mellitus in Low-income Rural Patients
    Hye-Yeon Kim, Woo-Jun Yun, Min-Ho Shin, Sun-Seong Kweon, Hye-Ran Ahn, Seong-Woo Choi, Young-Hoon Lee, Dong-Hyeok Cho, Jung-Ae Rhee
    Journal of Preventive Medicine and Public Health.2009; 42(5): 315.     CrossRef
  • Prevalence of Pancreatic Cancer in Diabetics and Clinical Characteristics of Diabetes-associated with Pancreatic Cancer - Comparison between Diabetes with and without Pancreatic Cancer -
    Seung Goun Hong, Jae Seon Kim, Sung Joo Jung, Moon Kyung Joo, Beom Jae Lee, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak
    The Korean Journal of Gastroenterology.2009; 54(3): 167.     CrossRef
Direct Medical Costs of Type 2 Diabetic Patients in the Tertiary Hospital.
Joo An Hwang, Tae Chin Park, Sun Hye Jung, Hae Jin Kim, Dae Jung Kim, So Hun Kim, Moon Suk Nam, Tae Hyun Kim, Moon Kyu Lee, Kwan Woo Lee
Korean Diabetes J. 2008;32(3):259-268.   Published online June 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.3.259
  • 2,365 View
  • 36 Download
  • 8 Crossref
AbstractAbstract PDF
BACKGROUND
Type 2 diabetes mellitus is a common, chronic and costly disease. Its prevalence is rapidly increasing worldwide. Diabetes has big economic burden mainly because of its chronic complications. We analyzed the annual direct medical costs of type 2 diabetic patients, including the costs associated with its complications in Korea retrospectively. METHODS: We enrolled 531 type 2 diabetic patients who had been treated in the 3 Tertiary Hospital in 2005. Clinical characteristics, duration of diabetes, modality of glycemic control, and presence of microvascular and macrovascular complications were assessed by the review of medical records. The annual direct medical costs were assessed using the hospital electronic database and included insurance covered and uncovered medical costs. RESULTS: The annual direct medical costs of type 2 diabetic patients without any complications was 1,184,563 won (95% CI for mean: 973,006~1,396,121 won). Compared to diabetic patients without complications, annual total medical costs increased 4.7-fold, 10.7-fold, and 8.8-fold in patients with microvascular complications, macrovascular complications and both complications, respectively. Hospitalization costs largely increased by 78.7-fold and 61.0-fold in patients with macrovascular complications and both complications, respectively. Major complications to increase medical costs were kidney transplantation (23.1-fold), dialysis (21.0-fold), PTCA or CABG (12.4-fold), and leg amputation (11.8-fold). The total medical costs dramatically increased according to the stage of diabetic retinopathy and nephropathy. CONCLUSION: Diabetic complications have a substantial impact on the direct medical costs of type 2 diabetic patients. The prevention of diabetic complications will benefit the patients as well as the overall healthcare expenditures.

Citations

Citations to this article as recorded by  
  • Policy Proposals for Infection Control in Patients with Chronic Wounds
    Kyung-Chul Moon, Donghyeok Shin, Kyu-Won Baek, Changsik John Pak, Young-Joon Jun
    Journal of Wound Management and Research.2022; 18(3): 249.     CrossRef
  • Effects of Co‐administration of Sulfonylureas and Antimicrobial Drugs on Hypoglycemia in Patients with Type 2 Diabetes Using a Case‐Crossover Design
    Sera Lee, Miyoung Ock, Hun‐Sung Kim, Hyunah Kim
    Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.2020; 40(9): 902.     CrossRef
  • The effect of continuity of care on the incidence of end-stage renal disease in patients with newly detected type 2 diabetic nephropathy: a retrospective cohort study
    Yun Jung Jang, Yoon Soo Choy, Chung Mo Nam, Ki Tae Moon, Eun-Cheol Park
    BMC Nephrology.2018;[Epub]     CrossRef
  • Social Welfare Information for Patients with Diabetes Mellitus
    Jea Yeon Lee
    The Journal of Korean Diabetes.2016; 17(2): 117.     CrossRef
  • Hypoglycemia and Health Costs
    Yong-ho Lee, Gyuri Kim, Eun Seok Kang
    The Journal of Korean Diabetes.2016; 17(1): 11.     CrossRef
  • Outcome Research in Diabetes
    Kwan Woo Lee
    Journal of Korean Diabetes.2011; 12(1): 2.     CrossRef
  • Costs of Diabetes Mellitus in Korea
    Kwan Woo Lee
    Diabetes & Metabolism Journal.2011; 35(6): 567.     CrossRef
  • How Much Amount of Socioeconomic Loss Is Caused by Digestive Diseases?
    Kyung Sik Park
    The Korean Journal of Gastroenterology.2011; 58(6): 297.     CrossRef
Prevalence and Clinical Characteristics of Aspirin Resistance in the Patients with Type 2 Diabetes Mellitus.
Mi Yeon Kang, Young Min Cho, Hyun Kyung Kim, Jee Hyun An, Hwa Young Ahn, Ji Won Yoon, Hoon Sung Choi, Jie Seon Lee, Kyong Soo Park, Seong Yeon Kim, Hong Kyu Lee
Korean Diabetes J. 2008;32(1):53-59.   Published online February 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.1.53
  • 2,626 View
  • 26 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
We examined the prevalence and clinical characteristics of aspirin resistance in the Korean patients with type 2 diabetes mellitus. METHODS: We studied 181 Korean patients with type 2 diabetes mellitus who were taking aspirin (100 mg/day for > or = 3 months) and no other antiplatelet agents. The VerifyNow System was used to determine aspirin responsiveness. Aspirin resistance was defined as an aspirin reaction unit (ARU) > or = 550. We measured the cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) to evaluate arteriosclerosis. The anthropometric parameters, electrocardiogram, blood pressure, fasting plasma glucose, lipid profiles, hemoglobin A1c, highly sensitive C-reactive protein (hsCRP), homocysteine, and microalbuminuria were measured in each patient. RESULTS: The prevalence of aspirin resistance in type 2 diabetic patients was 9.4% (17 of 181). Those who had aspirin resistance were older than those without aspirin resistance (64.6 +/- 10.6 vs. 59.8 +/- 8.1, P = 0.024). Aspirin resistance was not associated with fasting plasma glucose, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, hemoglobin A1c, hsCRP, homocysteine, microalbuminuria, ABI, CAVI, and body mass index. CONCLUSION: Prevalence of aspirin resistance in the Korean patients with type 2 diabetes mellitus was 9.4%. Although aspirin resistance was associated with old age, we could not find any good clinical parameter to predict it. Therefore, aspirin resistance should be evaluated in diabetic patients taking aspirin for prevention of cardiovascular complications.

Citations

Citations to this article as recorded by  
  • Long Non-Coding RNA H19 Positively Associates With Aspirin Resistance in the Patients of Cerebral Ischemic Stroke
    Jue Wang, Bin Cao, Yan Gao, Dong Han, Haiping Zhao, Yuhua Chen, Yumin Luo, Juan Feng, Yanxia Guo
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • 6th Asian PAD Workshop

    Annals of Vascular Diseases.2015; 8(2): 135.     CrossRef
  • Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes
    Jong Dai Kim, Cheol-Young Park, Kue Jeong Ahn, Jae Hyoung Cho, Kyung Mook Choi, Jun Goo Kang, Jae Hyeon Kim, Ki Young Lee, Byung Wan Lee, Ji Oh Mok, Min Kyong Moon, Joong Yeol Park, Sung Woo Park
    Atherosclerosis.2014; 234(1): 146.     CrossRef
Inflammatory Markers are Associated with Microvascular Complications in Type 2 Diabetes.
Sun Mee Yang, Sung Yong Kim, Ki Young Lee, Yeun Sun Kim, Moon Suk Nam, Ie Byung Park
Korean Diabetes J. 2007;31(6):472-479.   Published online November 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.6.472
  • 2,330 View
  • 37 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Inflammatory markers are known to be sensitive predictors of atherosclerotic disease such as coronary heart disease. Diabetic patients have higher level of inflammatory markers such as fibrinogen, high sensitivity C-reactive protein (hsCRP) or IL-6. We investigated the association of inflammatory markers with microvascular complications in type 2 diabetes. METHODS: We studied cross-sectionally 244 consecutive patients with type 2 diabetes without macrovascular disease such as cerebral infarct, coronary heart disease and peripheral arterial disease. The urinary albumin/creatinine ratio was determined in a morning, untimed, urine specimen. Ophthalmoscopic examinations were performed to evaluate diabetic retinopathy. Diabetic neuropathy was examined by 10-g monofilament, Neuropathic Disability Score and Michigan Neuropathy Screening Instrument. RESULTS: 47 patients (23.5%) had diabetic retinopathy, 81 (34.6%) had nephropathy and 132 (54.2%) had neuropathy. Fibrinogen and erythrocyte sedimentation rate (ESR) were significantly higher in the patients with nephropathy, retinopathy and neuropathy than in those without (P = 0.009, 0.003 and 0.047; P = 0.011, 0.02 and 0.006 , respectively). There were no differences in the hsCRP and IL-6 level between in patients with microvascular complications and in those without. Inflammatory parameters were correlated with each other. The hsCRP was correlated with IL-6 (r = 0.40, P < 0.001) and fibrinogen (r = 0.45, P < 0.001), but fibrinogen was not significantly correlated with IL-6 (r = 0.13, P = 0.08). CONCLUSION: Although IL-6, hsCRP and fibrinogen may be associated with microvascular complications in type 2 diabetes, we show that fibrinogen is a strong marker of microvascular complications.

Citations

Citations to this article as recorded by  
  • Hesperetin suppresses LPS/high glucose-induced inflammatory responses via TLR/MyD88/NF-κB signaling pathways in THP-1 cells
    Aeri Lee, HyunJi Gu, Min-Hee Gwon, Jung-Mi Yun
    Nutrition Research and Practice.2021; 15(5): 591.     CrossRef
In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications.
Ji Sun Nam, Young Jae Cho, Tae Woong Noh, Chul Sik Kim, Jong Suk Park, Min ho Cho, Hai Jin Kim, Ji Eun Yoon, Han Young Jung, Eun Seok Kang, Yu Mie Rhee, Hyung Keun Lee, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
Korean Diabetes J. 2007;31(4):351-361.   Published online July 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.4.351
  • 2,692 View
  • 19 Download
AbstractAbstract PDF
BACKGROUND
In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. From IVCCM, we measured corneal nerve density, branch, and tortuosity, total corneal/epithelial thickness, and the number of endothelial/keratocyte cells, and we checked patients' biochemical profiles and serum and tear NGF levels. RESULTS: Patients with more severe neuropathy had less corneal endothelial cells (3105 +/- 218 vs. 2537 +/- 142 vs. 2350 +/- 73/mm3 vs. 1914 +/- 465/mm3, P = 0.02), higher serum NGF (36 +/- 15 vs. 60 +/- 57.66 vs. 80 +/- 57.63 vs. 109 +/- 60.81 pg/mL, P = 0.39) and tear NGF levels (135.00 +/- 11.94 vs. 304.29 +/- 242.44 vs. 538.50 +/- 251.92 vs. 719.50 +/- 92.63 pg/mL, P = 0.01). There was a positive correlation between neuropathy and corneal nerve tortuosity (r2 = 0.479, P = 0.044) and negative correlation between neuropathy and endothelial cell count (r2 = -0.709, P = 0.002). Interestingly, similar changes were seen in other microvascular complications as well. CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study.
High Glucose Modulates Vascular Smooth Muscle Cell Proliferation Through Activation of PKC-sigma-dependent NAD(P)H oxidase.
Bo Hyun Kim, Chang Won Lee, Jung Lae Park, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
Korean Diabetes J. 2006;30(6):416-427.   Published online November 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.6.416
  • 1,983 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Oxidative stress is thought to be one of the causative factors contributing to macrovascular complications in diabetes. However, the mechanisms of development and progression of diabetic vascular complications are poorly understood. We hypothesized that PKC-sigma isozyme contributes to ROS generation and determined their roles in the critical intermediary signaling events in high glucose-induced proliferation of vascular smooth muscle (VSM) cells. METHODS: We treated primary cultured rat aortic smooth muscle cells for 72 hours with medium containing 5.5 mmol/L D-glucose (normal glucose), 30 mmol/L D-glucose (high glucose) or 5.5 mmol/L D-glucose plus 24.5 mmol/L mannitol (osmotic control). We then measured cell number, BrdU incorporation, cell cycle and superoxide production in VSM cells. Immunoblotting of PKC isozymes using phoshospecific antibodies was performed, and PKC activity was also measured. RESULTS: High glucose increased VSM cell number and BrdU incorporation and displayed significantly greater percentages of S and G2/M phases than compared to 5.5 mmol/L glucose and osmotic control. The nitroblue tetrazolium (NBT) staining in high glucose-treated VSM cell was more prominent compared with normal glucose-treated VSM cell, which was significantly inhibited by DPI (10 micrometer), but not by inhibitors for other oxidases. High glucose also markedly increased activity of PKC-sigma isozyme. When VSM cells were treated with rottlerin, a specific inhibitor of PKC-sigma or transfected with PKC-sigma siRNA, NBT staining and NAD(P)H oxidase activity were significantly attenuated in the high glucose-treated VSM cells. Furthermore, inhibition of PKC-sigma markedly decreased VSM cell number by high glucose. CONCLUSION: These results suggest that high glucose-induced VSM cell proliferation is dependent upon activation of PKC-sigma, which may responsible for elevated intracellular ROS production in VSM cells, and this is mediated by NAD(P)H oxidase.

Citations

Citations to this article as recorded by  
  • High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils
    Sang Soo Kim, Sun Young Kim, Soo Hyung Lee, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
    Korean Diabetes Journal.2009; 33(2): 94.     CrossRef
Mitochondrial DNA 5178 C>A Polymorphism is Associated with Serum Lipid Levels.
Hyeon Jae Kim, Min Young Cho, Min Kim, Ku Cheol Park, Goo Jun Kang, Cheol Hak Jang, Yeon Seong Kim, Kyu Hong Lee, Soo Kyong Park
Korean Diabetes J. 2004;28(6):501-510.   Published online December 1, 2004
  • 995 View
  • 18 Download
AbstractAbstract PDF
BACKGROUND
The mitochondrial DNA 5178 C>A polymorphism (Mt5178A) has been reported to the be associated with longevity, serum lipid levels and acute myocardial infarction in Japanese population. However, most of the studies on this subject have been confined to the Japanese population, and there have been fewer studies that tried to prove the association between Mt5178A polymorphism and type 2 diabetes or diabetic macrovascular complication. METHODS: The mt5178A polymorphism was genotyped in 658 type 2 diabetic patients and 334 non-diabetic controls subjects, and information on all the subjects' coronary heart disease and cerebrovascular disease was obtained from chart records. The anthropometric parameters, fasting blood glucose, insulin and lipid profiles were then measured. RESULTS: The frequency of the Mt5178A genotype in the control group (109/334; 32.6%) was not different from that found in the type 2 diabetic patients (223/658; 33.9%). The prevalence of cerebrovascular disease and coronary heart disease in the type 2 diabetic patients was not different between the Mt5178A genotype and the Mt5178C genotype. However, after adjustments for age and the body mass index, the HDL cholesterol concentration in men carrying the Mt5178A genotype was significantly higher than the HDL cholesterol concentration in men carrying the Mt5178C genotype (P = 0.007). The triglyceride concentration in women carrying the Mt5178A genotype was significantly lower than that in women carrying the Mt5178C genotype (P = 0.007). In addition, the frequency of the Mt5178A genotype in the control group increased with advanced age (P = 0.002). CONCLUSION: We could not find the association between Mt5178A and type 2 diabetes or diabetic macrovascular complication. However, the Mt5178 C>A polymorphism is associated with serum lipid levels and its frequency is increased with advanced age
The Relation Between Serum and Intracellular Magnesium Level And Diabetic Microvascular Complications.
Kyung Hoon Min, Ji Hye Kim, Eun Kyung Choi, Ji Hyun Park, Hong Sun Baek, Tian Ze Ma, Bing Zhe Hong, Yong Geun Kwak, Hyung Sub Kang, Tae Sun Park
Korean Diabetes J. 2004;28(4):284-292.   Published online August 1, 2004
  • 1,328 View
  • 19 Download
AbstractAbstract PDF
BACKGROUND
Low serum magnesium levels are related to diabetes mellitus (DM), high blood pressure (HBP) and metabolic syndrome (MS). However, as far as is known, there have been no previous studies analyzing the relevance of the serum and intracellular magnesium concentrations in diabetic microvascular complication individuals compared with healthy individuals. SUBJECTS AND METHODS: A pilot study was performed to compare 35 individuals with DM with 22 disease-free control subjects. The serum and intracellular magnesium levels of each group were measured, and found to be elevated in the diabetic group with diabetic microvascular complications. RESULTS: The mean serum magnesium levels among the subjects with DM and the control subjects were 0.0503 +/- 0.0750 and 0.9166 0.1149 mmol/L (p<0.001), respectively. The mean intracellular magnesium levels among the subjects with DM and the control subjects were 3.3548+/-0.1863 and 3.6732 0.2428 mM/mg protein (p<0.001), respectively. In those diabetic subjects whose serum magnesium concentration was measured, 28 had diabetic retinopathy, 30 diabetic nephropathy and 20 diabetic neuropathy. The mean serum magnesium concentrations of each diabetic microvascular complication were 0.9320 0.2813, 0.9259 0.1188 and 0.9305 0.1293 mmol/L, respectively, which that were significantly lower than those of the healthy subjects (p<0.001, p<0.001 and p<0.01). Also, the diabetic subjects whose intracellular magnesium concentrations were measured, 13 had diabetic retinopathy, 15 diabetic nephropathy and 9 diabetic neuropathy. The mean intracellular magnesium concentrations of each diabetic microvascular complication were 3.3484 0.1607, 3.3289 0.1832 and 3.3768 0.2096 mM/mg protein, respectively, and were also significantly lower than those of the healthy subjects (p<0.001and p<0.01). Each diabetic microvascular complication was also negatively correlated with the serum magnesium and intracellular magnesium levels. CONCLUSION: This study reveals that a significant relation ship exists between low serum and intracellular magnesium levels and diabetic microvascular complications, particularly retinopathy and nephropathy. A large scale study on these subjects will be required to generalize our results.
Relationship between Serum Homocysteine Levels and Vascular Complications in Type 2 Diabetic Patients.
Seung Jin Choi, Jae Taek Kim, Yeon Sahng Oh, Soon Hyun Shinn
Korean Diabetes J. 2002;26(2):112-125.   Published online April 1, 2002
  • 888 View
  • 18 Download
AbstractAbstract PDF
BACKGROUND
Chronic complications in type 2 diabetic patients have microvascular and macrovascular components. Previous studies have shown that incidence of macrovascular complications correlates with the serum homocysteine levels, but the relationship is unclear. In addition, the connection between the microvascular complications and the serum homocysteine levels is still obscure and controversial. In this study, the relationship between the serum homocysteine levels and microvascular and macrovascular complications were evaluated in type 2 diabetic patients. METHODS: In 58 type 2 diabetic patients, the serum homocysteine levels, folic acid levels, Vit B12 levels, PAI-1 levels, the standard risk factors for macrovascular complications, the fasting serum glucose levels, the HbA1C levels, and the fasting insulin and C-peptide concentrations, the renal function tests, and the carotid intima-media thickness were measured and the relationship between them and the serum homocysteine level was analyzed according to the presence and absence of macrovascular and microvascular complications. RESULTS: 1) In type 2 diabetic patients, the mean serum homocysteine level was 9.9+/-.2 mol/L. The serum homocysteine level showed no relationship with the clinical and biochemical variables including the risk factors for atherosclerosis except the serum creatinine and creatinine clearance. 2) The maximum, minimum, and mean of the intima- media thickness of right carotid artery were 4.00+/-.20, 0.50+/-.04, 1.04+/-.62 mm, of left carotid artery were 3.54+/-.00, 0.31+/-.02, 1.03+/-.55 mm, and means were 3.77+/-.10, 0.44+/-.03, 1.03+/-.54 mm, and correlated with the serum homocysteine leve l (p=0.03), but only the serum LDL cholesterol level independently correlated with the intima-media thickness (p=0.04). 3) The serum homocysteine level (p=0.01) and intima-media thickness (p<0.01) was significantly higher in type 2 diabetic patients with macrovascular complications than without it. 4) The serum homocysteine level did not correlate with the incidence microvascular complications, but the intima-media thickness did correlate with diabetic nephropathy (p=0.03). CONCLUSIONS: The serum homocysteine level did not correlated with the incidence of diabetic microvascular complications. However, there was a small correlation with the risk factors of macrovascular complications. The intima- media thickness correlated with the incidence of macrovascular complications, and the relationship with diabetic nephropathy requires further study.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer