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Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function
Kwang-Sook Woo, Jae-Lim Choi, Bo-Ram Kim, Ji-Eun Kim, Jin-Yeong Han
Diabetes Metab J. 2014;38(4):278-284.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.278
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  • 24 Web of Science
  • 26 Crossref
AbstractAbstract PDFPubReader   
Background

Accurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status.

Methods

Our study included 37 samples from diabetic chronic kidney disease (CKD) patients for whom serum creatinine tests had been requested and 40 samples from a healthy populations in Dong-A University Hospital between May 2010 and June 2010. The assay precision (i.e., the coefficient of variation) and the reference range of the serum cystatin C test were evaluated. We compared the estimated glomerular filtration rates (GFRs) based on cystatin C with those based on creatinine. Moreover, we investigated the influences of age, gender, weight, and muscle mass on serum creatinine and serum cystatin C.

Results

There was a positive correlation between GFR based on creatinine and that based on cystatin C (r=0.79, P<0.0001) among the diabetic CKD patients. Serum creatinine and cystatin C were significantly correlated with body weight and muscle mass, but the strengths of these correlations were greater for serum creatinine. The precision study revealed excellent results for both the high and low controls. The 95% reference interval of cystatin C in the healthy population was 0.371 to 1.236 mg/L.

Conclusion

Based on these results, we conclude that, despite the strong correlation between serum creatinine and cystatin C, cystatin C is less affected by weight and muscle mass and might represent a better alternative for the assessment of renal function.

Citations

Citations to this article as recorded by  
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    Tadesse Asmamaw Dejenie, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizchew Ambaw Kassie, Amanuel Yosef Gebrekidan, Molalegn Mesele Gesese, Kirubel Dagnaw Tegegne, Denekew Tenaw A
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association between serum creatinine and type 2 diabetes in the Chinese population: a retrospective cohort study
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    Scientific Reports.2023;[Epub]     CrossRef
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    Jaehyun Bae, Byung-Wan Lee
    Biomedicines.2023; 11(7): 1928.     CrossRef
  • Reconsideration of the current models of estimated kidney function‐based drug dose adjustment in older adults: The role of biological age
    Radin Alikhani, Manjunath P. Pai
    Clinical and Translational Science.2023; 16(11): 2095.     CrossRef
  • The Level of Plasma Cystatin C in Patients with Chronic Kidney Disease
    Tuan Nguyen Van, Linh Phan Ha, Diep Pham Thao, Minh Nguyen Thi Binh, Minh Hoang Thi, Thuan Huynh Quang, Lan Thi Phuong Dam
    Nephro-Urology Monthly.2022;[Epub]     CrossRef
  • Role of cystatin C in urogenital malignancy
    Li Ding, Zijie Liu, Junqi Wang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Comparison of cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy
    Ching-Way Chen, Cheng-Hsuan Tsai, Chi-Sheng Hung, I-Jung Tsai, Yu-Wei Chiu, Chin-Cheng Chang, Kao-Lang Liu, Shih-Cheng Liao, Vin-Cent Wu, Yen-Hung Lin
    Clinica Chimica Acta.2021; 520: 147.     CrossRef
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  • Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury
    Yanqun Wu, Shunhua Wang, Xiaoqing Xu
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  • The role of serum cystatin C in estimation of renal function in survivors of critical illness
    Jirarat Eiamcharoenying, Win Kulvichit, Nuttha Lumlertgul, Tawatchai Chaiwatanarat, Sadudee Peerapornratana, Nattachai Srisawat
    Journal of Critical Care.2020; 59: 201.     CrossRef
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    James Roland Markos, Karen S. Schaepe, Hilary R. Teaford, Andrew D. Rule, Kianoush B. Kashani, John C. Lieske, Erin F. Barreto, Pierre Delanaye
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    Caroline Pereira Domingueti, Rodrigo Bastos Fóscolo, Ana Cristina Simões e Silva, Luci Maria S. Dusse, Janice Sepúlveda Reis, Maria das Graças Carvalho, Ana Paula Fernandes, Karina Braga Gomes
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  • Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis
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  • Performance of Cystatin C– and Creatinine-Based Estimated Glomerular Filtration Rate Equations Depends on Patient Characteristics
    Jeffrey W Meeusen, Andrew D Rule, Nikolay Voskoboev, Nikola A Baumann, John C Lieske
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    Mahmoud Omar, Wael Abdel-Razek, Gamal Abo-Raia, Medhat Assem, Gasser El-Azab
    International Journal of Hepatology.2015; 2015: 1.     CrossRef
  • Efficient expression, purification and characterization of native human cystatin C in Escherichia coli periplasm
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    Protein Expression and Purification.2015; 111: 18.     CrossRef
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Association of Serum Cystatin C with Metabolic Syndrome and Its Related Components in Korean Adults.
Sun Young Kim, Sang Heon Song, Yun Kyung Jeon, Ji Ryang Kim, Jung Ho Bae, Sang Soo Kim, Soo Hyung Lee, Seok Man Son, In Ju Kim, Yong Ki Kim, Yang Ho Kang
Korean Diabetes J. 2008;32(5):409-417.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.409
  • 2,473 View
  • 21 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
Serum cystatin C has been reported as a better marker than serum creatinine for estimation of kidney function and may be associated with cardiovascular disease. The aim of this study was to elucidate the association of serum cystatin C with metabolic syndrome (MS), a constellation of cardiovascular risk factors, and its related components and the usefulness of serum cystatin C for the cardiovascular risk assessment. METHODS: 1,468 healthy subjects (814 men and 655 women), who visited health promotion center of Pusan National University Hospital for routine medical checkup were included. MS was defined by modified, revised National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria. RESULTS: Mean serum cystatin C value was 0.87 +/- 0.17 mg/L. In partial correlation analysis adjusted by age, sex and Glomerular Filtration Rate (GFR), cystatin C was associated with most of metabolic parameters and especially had significant positive correlation with waist circumference (r = 0.215), triglyceride (TG) (r = 0.141), diastolic blood pressure (BP) (r = 0.116), and correlated negatively with high density lipoprotein (HDL) cholesterol (r = -0.152) (all P < 0.001). There were increasing trends of prevalence of MS with the increase of quartiles of cystatin C and as the number of MS components increased, cystatin C values significantly increased. Serum cystatin C was also significantly increased in MS (0.90 +/- 0.19 mg/L vs. 0.86 +/- 0.16 mg/L). In stepwise multiple regression analysis including the components of MS, Waist circumference, diastolic BP, triglyceride, and HDL cholesterol were independent determinants of serum cystatin C, but with creatinine, only waist circumference was independent determinant. CONCLUSIONS: Serum cystatin C was closely associated with MS and its related cardiovascular risk factors and might be useful as a tool of cardiovascular risk assessment.

Citations

Citations to this article as recorded by  
  • Cystatin C in Patients of Metabolic Syndrome and its Correlation with the Individual Components of Metabolic Syndrome
    Sunita Aghade, Jayshree S Bavikar, Pragati S Kadam, Reshakiran J Shendye
    Indian Journal of Medical Biochemistry.2019; 23(2): 293.     CrossRef
  • Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2016; 40(1): 32.     CrossRef
  • Association of Obesity with Serum Cystatin C in Korean Adults
    Yang Ho Kang
    The Korean Journal of Obesity.2015; 24(4): 199.     CrossRef

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