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Basic Research
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Serotonin Regulates Lipogenesis and Endoplasmic Reticulum Stress in Alcoholic Liver Disease
Inseon Hwang, Jung Eun Nam, Wonsuk Choi, Won Gun Choi, Eunji Lee, Hyeongseok Kim, Young-Ah Moon, Jun Yong Park, Hail Kim
Received April 26, 2024  Accepted September 21, 2024  Published online February 5, 2025  
DOI: https://doi.org/10.4093/dmj.2024.0215    [Epub ahead of print]
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AbstractAbstract PDF
Background
Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine neurotransmitter that has various functions in central and peripheral tissues. While 5-HT is known to regulate various biological processes in liver, direct role of 5-HT and its receptors, especially 5-HT receptor 2A (HTR2A) and HTR2B, in development and progression of alcoholic liver disease (ALD) in vivo is not well understood.
Methods
Blood 5-HT level was measured from both human ALD patients and ethanol (EtOH) diet-fed mouse models. Gut-specific tryptophan hydroxylase 1 (Tph1) knockout mice, liver-specific Htr2a knockout mice, and liver-specific Htr2b knockout mice were fed with EtOH diet. Then we evaluated liver damage, hepatic steatosis, endoplasmic reticulum (ER) stress, and inflammation.
Results
Blood 5-HT concentrations are increased in both humans and mice with ALD. Both gut-specific Tph1 knockout and liver- specific Htr2a knockout mice are resistant to steatosis by down-regulating lipogenic pathways in liver of chronic EtOH diet-fed mice. Moreover, genetic inhibition of both gut-derived serotonin (GDS) synthesis and hepatic HTR2A signaling prevents ER stress in liver of chronic EtOH diet-fed mice. Additionally, we found that ablation of HTR2A signaling protects against disease progression by attenuating liver injury and inflammation in chronic plus binge EtOH diet-fed mice. Also, inhibiting HTR2A signaling ameliorates alcohol-induced liver injury and ER stress in an acute EtOH diet-fed mice model.
Conclusion
GDS directly regulates lipogenesis and ER stress via signaling through hepatic HTR2A in the context of ALD. Inhibiting HTR2A signaling protects against alcohol-induced steatosis, liver injury and disease progression in various ALD mouse models and may also provide a novel therapeutic strategy for ALD.
Basic Research
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Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
Praise Chanmee Kim, Ji Seon Lee, Sung Soo Chung, Kyong Soo Park
Diabetes Metab J. 2023;47(3):382-393.   Published online March 6, 2023
DOI: https://doi.org/10.4093/dmj.2022.0156
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  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Leptin is a 16-kDa fat-derived hormone with a primary role in controlling adipose tissue levels. Leptin increases fatty acid oxidation (FAO) acutely through adenosine monophosphate-activated protein kinase (AMPK) and on delay through the SUMO-specific protease 2 (SENP2)–peroxisome proliferator-activated receptor δ/γ (PPARδ/γ) pathway in skeletal muscle. Leptin also directly increases FAO and decreases lipogenesis in adipocytes; however, the mechanism behind these effects remains unknown. Here, we investigated the role of SENP2 in the regulation of fatty acid metabolism by leptin in adipocytes and white adipose tissues.
Methods
The effects of leptin mediated by SENP2 on fatty acid metabolism were tested by siRNA-mediated knockdown in 3T3-L1 adipocytes. The role of SENP2 was confirmed in vivo using adipocyte-specific Senp2 knockout (Senp2-aKO) mice. We revealed the molecular mechanism involved in the leptin-induced transcriptional regulation of carnitine palmitoyl transferase 1b (Cpt1b) and long-chain acyl-coenzyme A synthetase 1 (Acsl1) using transfection/reporter assays and chromatin immunoprecipitation.
Results
SENP2 mediated the increased expression of FAO-associated enzymes, CPT1b and ACSL1, which peaked 24 hours after leptin treatment in adipocytes. In contrast, leptin stimulated FAO through AMPK during the initial several hours after treatment. In white adipose tissues, FAO and mRNA levels of Cpt1b and Acsl1 were increased by 2-fold 24 hours after leptin injection in control mice but not in Senp2-aKO mice. Leptin increased PPARα binding to the Cpt1b and Acsl1 promoters in adipocytes through SENP2.
Conclusion
These results suggest that the SENP2-PPARα pathway plays an important role in leptin-induced FAO in white adipocytes.

Citations

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  • Intermittent cold stimulation affects energy metabolism and improves stress resistance in broiler heart
    Tingting Li, Haidong Wei, Shijie Zhang, Xiaotao Liu, Lu Xing, Yuanyuan Liu, Rixin Gong, Jianhong Li
    Poultry Science.2024; 103(1): 103190.     CrossRef
Short Communication
Basic Research
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GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells
Joo Won Kim, Eun Roh, Kyung Mook Choi, Hye Jin Yoo, Hwan-Jin Hwang, Sei Hyun Baik
Diabetes Metab J. 2022;46(3):506-511.   Published online January 24, 2022
DOI: https://doi.org/10.4093/dmj.2021.0092
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  • 253 Download
  • 13 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   ePub   
Endothelial dysfunction is strongly linked with inflammatory responses, which can impact cardiovascular disease. Recently, G protein-coupled receptor 40 (GPR40) has been investigated as a modulator of metabolic stress; however, the function of GPR40 in vascular endothelial cells has not been reported. We analyzed whether treatment of GPR40-specific agonists modulated the inflammatory responses in human umbilical vein endothelial cells (HUVECs). Treatment with LY2922470, a GPR40 agonist, significantly reduced lipopolysaccharide (LPS)-mediated nuclear factor-kappa B (NF-κB) phosphorylation and movement into the nucleus from the cytosol. However, treatment with another GPR40 agonist, TAK875, did not inhibit LPS-induced NF-κB activation. LPS treatment induced expression of adhesion molecules vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) and attachment of THP-1 cells to HUVECs, which were all decreased by LY2922470 but not TAK875. Our results showed that ligand-dependent agonism of GPR40 is a promising therapeutic target for overcoming inflammatory reactions in the endothelium.

Citations

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  • Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships
    Abhik Paul, Sourin Nahar, Pankaj Nahata, Arnab Sarkar, Avik Maji, Ajeya Samanta, Sanmoy Karmakar, Tapan Kumar Maity
    European Journal of Medicinal Chemistry.2024; 264: 115990.     CrossRef
  • Metabolite-sensing GPCRs in rheumatoid arthritis
    Xuezhi Yang, Wankang Zhang, Luping Wang, Yingjie Zhao, Wei Wei
    Trends in Pharmacological Sciences.2024; 45(2): 118.     CrossRef
  • Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity
    Weilian Bao, Jiaren Lyu, Guize Feng, Linfeng Guo, Dian Zhao, Keyuan You, Yang Liu, Haidong Li, Peng Du, Daofeng Chen, Xiaoyan Shen
    Acta Pharmaceutica Sinica B.2024; 14(9): 3964.     CrossRef
  • IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-κB signaling pathways to promote wound healing
    Xin Zhang, Fei Hu, Jie Li, Lin Chen, Yu-fei Mao, Qiu-bo Li, Chen-yao Nie, Cai Lin, Jian Xiao
    European Journal of Pharmaceutical Sciences.2024; 200: 106847.     CrossRef
  • Free Fatty Acids and Free Fatty Acid Receptors: Role in Regulating Arterial Function
    Fengzhi Yu, Boyi Zong, Lili Ji, Peng Sun, Dandan Jia, Ru Wang
    International Journal of Molecular Sciences.2024; 25(14): 7853.     CrossRef
  • Critical role of G protein-coupled receptor 40 in B cell response and the pathogenesis of rheumatoid arthritis in mice and patients
    Anqi Li, Xiaoyi Wang, Jingwen Li, Xiaoyu Li, Jue Wang, Yang Liu, Zhihong Wang, Xiaobing Yang, Jiapeng Gao, Juanjie Wu, Tao Sun, Lixia Huo, Yanfeng Yi, Jiantong Shen, Jiexun Cai, Yunliang Yao
    Cell Reports.2024; 43(10): 114858.     CrossRef
  • Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists
    Lei Liu, Qinghua Zhang, Yichuan Ma, Ling Lin, Wenli Liu, Aizhong Ding, Chunjian Wang, Shuiping Zhou, Jinyong Cai, Hai Tang
    Drug Design, Development and Therapy.2024; Volume 18: 5961.     CrossRef
  • GPR40 deficiency worsens metabolic syndrome‐associated periodontitis in mice
    Yanchun Li, Zhongyang Lu, Cameron L. Kirkwood, Keith L. Kirkwood, Stephen A. Wank, Ai‐Jun Li, Maria F. Lopes‐Virella, Yan Huang
    Journal of Periodontal Research.2023; 58(3): 575.     CrossRef
  • Signaling pathways and intervention for therapy of type 2 diabetes mellitus
    Rong Cao, Huimin Tian, Yu Zhang, Geng Liu, Haixia Xu, Guocheng Rao, Yan Tian, Xianghui Fu
    MedComm.2023;[Epub]     CrossRef
  • G Protein-Coupled Receptor 40 Agonist LY2922470 Alleviates Ischemic-Stroke-Induced Acute Brain Injury and Functional Alterations in Mice
    Yingyu Lu, Wanlu Zhou, Qinghua Cui, Chunmei Cui
    International Journal of Molecular Sciences.2023; 24(15): 12244.     CrossRef
  • AM1638, a GPR40-Full Agonist, Inhibited Palmitate- Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner
    Hwan-Jin Hwang, Joo Won Kim, SukHwan Yun, Min Jeong Park, Eyun Song, Sooyeon Jang, Ahreum Jang, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Endocrinology and Metabolism.2023; 38(6): 760.     CrossRef
  • Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders
    Hong-Ping Guan, Yusheng Xiong
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
Original Article
Genetics
Article image
Enhancer-Gene Interaction Analyses Identified the Epidermal Growth Factor Receptor as a Susceptibility Gene for Type 2 Diabetes Mellitus
Yang Yang, Shi Yao, Jing-Miao Ding, Wei Chen, Yan Guo
Diabetes Metab J. 2021;45(2):241-250.   Published online June 10, 2020
DOI: https://doi.org/10.4093/dmj.2019.0204
  • 7,237 View
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  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Genetic interactions are known to play an important role in the missing heritability problem for type 2 diabetes mellitus (T2DM). Interactions between enhancers and their target genes play important roles in gene regulation and disease pathogenesis. In the present study, we aimed to identify genetic interactions between enhancers and their target genes associated with T2DM.

Methods

We performed genetic interaction analyses of enhancers and protein-coding genes for T2DM in 2,696 T2DM patients and 3,548 controls of European ancestry. A linear regression model was used to identify single nucleotide polymorphism (SNP) pairs that could affect the expression of the protein-coding genes. Differential expression analyses were used to identify differentially expressed susceptibility genes in diabetic and nondiabetic subjects.

Results

We identified one SNP pair, rs4947941×rs7785013, significantly associated with T2DM (combined P=4.84×10−10). The SNP rs4947941 was annotated as an enhancer, and rs7785013 was located in the epidermal growth factor receptor (EGFR) gene. This SNP pair was significantly associated with EGFR expression in the pancreas (P=0.033), and the minor allele “A” of rs7785013 decreased EGFR gene expression and the risk of T2DM with an increase in the dosage of “T” of rs4947941. EGFR expression was significantly upregulated in T2DM patients, which was consistent with the effect of rs4947941×rs7785013 on T2DM and EGFR expression. A functional validation study using the Mouse Genome Informatics (MGI) database showed that EGFR was associated with diabetes-relevant phenotypes.

Conclusion

Genetic interaction analyses of enhancers and protein-coding genes suggested that EGFR may be a novel susceptibility gene for T2DM.

Citations

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  • Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design
    Xiaoyi Li, Zechen Zhou, Yujia Ma, Kexin Ding, Han Xiao, Tao Wu, Dafang Chen, Yiqun Wu
    Biomedicines.2025; 13(1): 120.     CrossRef
  • Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach
    Jianing Ren, Jing Dai, Yue Chen, Zhenzhen Wang, Ruyi Sha, Jianwei Mao, Yangchen Mao
    Metabolites.2024; 14(4): 224.     CrossRef
  • Association of Uterine Leiomyoma with Type 2 Diabetes Mellitus in Young Women: A Population-Based Cohort Study
    Ji-Hee Sung, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    Diabetes & Metabolism Journal.2024; 48(6): 1105.     CrossRef
  • Genome-Wide Epistasis Study of Cerebrospinal Fluid Hyperphosphorylated Tau in ADNI Cohort
    Dandan Chen, Jin Li, Hongwei Liu, Xiaolong Liu, Chenghao Zhang, Haoran Luo, Yiming Wei, Yang Xi, Hong Liang, Qiushi Zhang
    Genes.2023; 14(7): 1322.     CrossRef
  • Investigation of the mechanism of Shen Qi Wan prescription in the treatment of T2DM via network pharmacology and molecular docking
    Piaopiao Zhao, Xiaoxiao Zhang, Yuning Gong, Weihua Li, Zengrui Wu, Yun Tang, Guixia Liu
    In Silico Pharmacology.2022;[Epub]     CrossRef
  • The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
    Raymond C. Harris
    Cells.2022; 11(21): 3416.     CrossRef
  • Co-expression Network Revealed Roles of RNA m6A Methylation in Human β-Cell of Type 2 Diabetes Mellitus
    Cong Chen, Qing Xiang, Weilin Liu, Shengxiang Liang, Minguang Yang, Jing Tao
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
Review
Drug/Regimen
Fibrates Revisited: Potential Role in Cardiovascular Risk Reduction
Nam Hoon Kim, Sin Gon Kim
Diabetes Metab J. 2020;44(2):213-221.   Published online April 23, 2020
DOI: https://doi.org/10.4093/dmj.2020.0001
  • 9,926 View
  • 378 Download
  • 55 Web of Science
  • 57 Crossref
AbstractAbstract PDFPubReader   

Fibrates, peroxisome proliferator-activated receptor-α agonists, are potent lipid-modifying drugs. Their main effects are reduction of triglycerides and increase in high-density lipoprotein levels. Several randomized controlled trials have not demonstrated their benefits on cardiovascular risk reduction, especially as an “add on” to statin therapy. However, subsequent analyses by major clinical trials, meta-analyses, and real-world evidence have proposed their potential in specific patient populations with atherogenic dyslipidemia and metabolic syndrome. Here, we have reviewed and discussed the accumulated data on fibrates to understand their current status in cardiovascular risk management.

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  • Apolipoprotein B-containing lipoproteins in atherogenesis
    Jan Borén, Chris J. Packard, Christoph J. Binder
    Nature Reviews Cardiology.2025;[Epub]     CrossRef
  • Associations of omega-3 fatty acids vs. fenofibrate with adverse cardiovascular outcomes in people with metabolic syndrome: propensity matched cohort study
    Nam Hoon Kim, Ji Yoon Kim, Jimi Choi, Sin Gon Kim
    European Heart Journal - Cardiovascular Pharmacotherapy.2024; 10(2): 118.     CrossRef
  • Role of PPARα in inflammatory response of C2C12 myotubes
    Yuki Shimizu, Keiko Hamada, Tingting Guo, Chie Hasegawa, Yusuke Kuga, Katsushi Takeda, Takashi Yagi, Hiroyuki Koyama, Hiroshi Takagi, Daisuke Aotani, Hiromi Kataoka, Tomohiro Tanaka
    Biochemical and Biophysical Research Communications.2024; 694: 149413.     CrossRef
  • Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
    John J. P. Kastelein, Andrew Hsieh, Mary R. Dicklin, Marc Ditmarsch, Michael H. Davidson
    Current Atherosclerosis Reports.2024; 26(2): 35.     CrossRef
  • Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases
    Virginia Actis Dato, Stephan Lange, Yoshitake Cho
    International Journal of Molecular Sciences.2024; 25(2): 1211.     CrossRef
  • ApoB100 and Atherosclerosis: What’s New in the 21st Century?
    Dimitris Kounatidis, Natalia G. Vallianou, Aikaterini Poulaki, Angelos Evangelopoulos, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Maria Dalamaga
    Metabolites.2024; 14(2): 123.     CrossRef
  • Follistatin-like 1 (FSTL1) levels as potential early biomarker of cardiovascular disease in a Mexican population
    N. Ponce-Ruíz, J. F. Herrera-Moreno, A. E. Rojas-García, B. S. Barrón-Vivanco, C. A. González-Arias, Y. Y. Bernal-Hernández, L. Ortega-Cervantes, J. Ponce-Gallegos, J. A. Hernández-Nolasco, I. M. Medina-Díaz
    Heart and Vessels.2024; 39(6): 563.     CrossRef
  • Role of Fenofibrate Use in Dyslipidemia and Related Comorbidities in the Asian Population: A Narrative Review
    Chaicharn Deerochanawong, Sin Gon Kim, Yu-Cheng Chang
    Diabetes & Metabolism Journal.2024; 48(2): 184.     CrossRef
  • Coenzyme Q10 in atherosclerosis
    Minjun Liao, Xueke He, Yangyang Zhou, Weiqiang Peng, Xiao-Mei Zhao, Miao Jiang
    European Journal of Pharmacology.2024; 970: 176481.     CrossRef
  • Onion Polyphenols as Multi-Target-Directed Ligands in MASLD: A Preliminary Molecular Docking Study
    Maria Rosaria Paravati, Anna Caterina Procopio, Maja Milanović, Giuseppe Guido Maria Scarlata, Nataša Milošević, Maja Ružić, Nataša Milić, Ludovico Abenavoli
    Nutrients.2024; 16(8): 1226.     CrossRef
  • Therapeutic approach in the treatment of dyslipidemia: Novelties and challenges
    Katarina Lalić, Nataša Rajković, Ljiljana Popović, Sandra Singh-Lukač, Iva Rasulić, Ana Petakov, Milica Krstić, Marija Mitrović
    Galenika Medical Journal.2024; 3(9): 31.     CrossRef
  • Research trends in lipid-lowering therapies for coronary heart disease combined with hyperlipidemia: a bibliometric study and visual analysis
    Quankai Cheng, Jingjing Sun, Haicheng Zhong, Ziming Wang, Chang Liu, Sheng Zhou, Jie Deng
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Expression of FAM159B in Humans, Rats, and Mice: A Cross-species Examination
    Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Amelie Lupp
    Journal of Histochemistry & Cytochemistry.2024; 72(7): 467.     CrossRef
  • The Pleiotropic Effects of Lipid-Modifying Interventions: Exploring Traditional and Emerging Hypolipidemic Therapies
    Dimitris Kounatidis, Nikolaos Tentolouris, Natalia G. Vallianou, Iordanis Mourouzis, Irene Karampela, Theodora Stratigou, Eleni Rebelos, Marina Kouveletsou, Vasileios Stamatopoulos, Eleni Tsaroucha, Maria Dalamaga
    Metabolites.2024; 14(7): 388.     CrossRef
  • Fenofibrate’s impact on cardiovascular risk in patients with diabetes: a nationwide propensity-score matched cohort study
    Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review
    Leisheng Wang, Shiwei Xu, Mengzhen Zhou, Hao Hu, Jinyou Li
    International Journal of Biological Macromolecules.2024; 278: 134835.     CrossRef
  • Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin in Patients with Type 2 Diabetes and Modifiable Cardiovascular Risk Factor
    Nam Hoon Kim, Juneyoung Lee, Suk Chon, Jae Myung Yu, In-Kyung Jeong, Soo Lim, Won Jun Kim, Keeho Song, Ho Chan Cho, Hea Min Yu, Kyoung-Ah Kim, Sang Soo Kim, Soon Hee Lee, Chong Hwa Kim, Soo Heon Kwak, Yong‐ho Lee, Choon Hee Chung, Sihoon Lee, Heung Yong J
    Endocrinology and Metabolism.2024; 39(5): 722.     CrossRef
  • Safety and Efficacy of the Novel RNA Interference Therapies for Hypertriglyceridemia and Mixed Hyperlipidemia Management: A Systematic Review and Meta-analysis
    A.B.M. Kamrul-Hasan, Deep Dutta, Lakshmi Nagendra, Sunetra Mondal, Saptarshi Bhattacharya, Sanjay Kalra
    Endocrine Practice.2024; 30(11): 1103.     CrossRef
  • Effects of Fatty Acid Metabolism on Heart Failure
    日娜 萨
    Advances in Clinical Medicine.2024; 14(09): 787.     CrossRef
  • Revisiting PPAR agonists: novel perspectives in the treatment of primary biliary cholangitis
    Yiran Chen, Kunyu Zheng, Gahu Da, Xu Wang, Yi Wei, Guochun Wang, Fengchun Zhang, Li Wang
    Expert Opinion on Pharmacotherapy.2024; 25(13): 1825.     CrossRef
  • Integrated review of cardiometabolic biomarkers and dietary nutrients
    Ravindra Verma, Prakash S Bisen, Mònica Bulló
    Journal of Food Bioactives.2024; : 44.     CrossRef
  • Cardiovascular Diseases and Metabolic Medications in the Lebanese Population: A Post Hoc Analysis from a Nationwide Cross-Sectional Study
    Rony M. Zeenny, Rachel Abdo, Chadia Haddad, Aline Hajj, Rouba Karen Zeidan, Pascale Salameh, Jean Ferrieres
    Pharmacy.2024; 12(6): 171.     CrossRef
  • From Adipose to Ailing Kidneys: The Role of Lipid Metabolism in Obesity-Related Chronic Kidney Disease
    Wenchao Xu, Yuting Zhu, Siyuan Wang, Jihong Liu, Hao Li
    Antioxidants.2024; 13(12): 1540.     CrossRef
  • Exploring the mechanism of fibrates regulating HIF-1A in the treatment of ischemic stroke based on network pharmacology and molecular docking
    Fengjiao Yang, Zixuan Yang, Ya Yan, Yun Gu, Pengyu Wang, Min Wang, Jianjie Chen, Xiaoshan Du, Guangming Wang
    BMC Research Notes.2024;[Epub]     CrossRef
  • Present and Future of Dyslipidaemia Treatment—A Review
    Iveta Merćep, Andro Vujević, Dominik Strikić, Ivana Radman, Ivan Pećin, Željko Reiner
    Journal of Clinical Medicine.2023; 12(18): 5839.     CrossRef
  • VLDL receptor gene therapy for reducing atherogenic lipoproteins
    Ronald M. Krauss, Jonathan T. Lu, Joseph J. Higgins, Cathryn M. Clary, Ray Tabibiazar
    Molecular Metabolism.2023; 69: 101685.     CrossRef
  • The emerging role of PPAR-alpha in breast cancer
    Zhiwen Qian, Lingyan Chen, Jiayu Liu, Ying Jiang, Yan Zhang
    Biomedicine & Pharmacotherapy.2023; 161: 114420.     CrossRef
  • Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease
    Yujie Pu, Chak Kwong Cheng, Hongsong Zhang, Jiang‐Yun Luo, Li Wang, Brian Tomlinson, Yu Huang
    Medicinal Research Reviews.2023; 43(6): 2086.     CrossRef
  • Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism
    DuoYao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A Bernstein, Aaron R Victor, Faizan Ahmed, Aoi O Hoshi, Luciana C Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Michifumi Yamashita, Ryan E Temel, Jorge F Giani, Daniel J Luthringer, Ajit S Divakar
    Cardiovascular Research.2023; 119(9): 1825.     CrossRef
  • Rapid flow synthesis of fenofibrate via scalable flash chemistry with in-line Li recovery
    Sanket A. Kawale, Dong-Chang Kang, Gwang-Noh Ahn, Amirreza Mottafegh, Ji-Ho Kang, Gi-Su Na, Dong-Pyo Kim
    Chemical Engineering Journal.2023; 477: 147033.     CrossRef
  • Effectiveness and Safety of Fenofibrate in Routine Treatment of Patients with Hypertriglyceridemia and Metabolic Syndrome
    Marat V. Ezhov, Gregory P. Arutyunov
    Diseases.2023; 11(4): 140.     CrossRef
  • Development of New Genome Editing Tools for the Treatment of Hyperlipidemia
    Giulio Preta
    Cells.2023; 12(20): 2466.     CrossRef
  • Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment
    Li Zhang, Yingying Tong, Yan Fang, Jinjin Pei, Qilan Wang, Gang Li
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Obesity and Dyslipidemia
    Barbora Nussbaumerova, Hana Rosolova
    Current Atherosclerosis Reports.2023; 25(12): 947.     CrossRef
  • Bibliometric analysis of residual cardiovascular risk: trends and frontiers
    Lin Wang, Sutong Wang, Chaoyuan Song, Yiding Yu, Yuehua Jiang, Yongcheng Wang, Xiao Li
    Journal of Health, Population and Nutrition.2023;[Epub]     CrossRef
  • Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen
    Ye Yang, Anne P. Beigneux, Wenxin Song, Le Phuong Nguyen, Hyesoo Jung, Yiping Tu, Thomas A. Weston, Caitlyn M. Tran, Katherine Xie, Rachel G. Yu, Anh P. Tran, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Yan Q. Chen, Eugene Y. Zhen, Joonyoung R.
    Journal of Clinical Investigation.2023;[Epub]     CrossRef
  • Blood-Derived Lipid and Metabolite Biomarkers in Cardiovascular Research from Clinical Studies: A Recent Update
    Dipali Kale, Amol Fatangare, Prasad Phapale, Albert Sickmann
    Cells.2023; 12(24): 2796.     CrossRef
  • Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridaemia
    Gary F Lewis, Robert A Hegele
    The Lancet Diabetes & Endocrinology.2022; 10(2): 142.     CrossRef
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    Biomedicines.2022; 10(1): 193.     CrossRef
  • Is there a role of lipid-lowering therapies in the management of fatty liver disease?
    Ismini Tzanaki, Aris P Agouridis, Michael S Kostapanos
    World Journal of Hepatology.2022; 14(1): 119.     CrossRef
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    Ana Clara Aprotosoaie, Alexandru-Dan Costache, Irina-Iuliana Costache
    Pharmaceutics.2022; 14(4): 722.     CrossRef
  • The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation
    Qinyue Lu, Weicheng Zong, Mingyixing Zhang, Zhi Chen, Zhangping Yang
    Agriculture.2022; 12(7): 947.     CrossRef
  • Current Trends of Big Data Research Using the Korean National Health Information Database
    Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee
    Diabetes & Metabolism Journal.2022; 46(4): 552.     CrossRef
  • New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
    Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
    Diabetes & Metabolism Journal.2022; 46(4): 517.     CrossRef
  • Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure
    Agata Jedrzejewska, Alicja Braczko, Ada Kawecka, Marcin Hellmann, Piotr Siondalski, Ewa Slominska, Barbara Kutryb-Zajac, Magdi H. Yacoub, Ryszard T. Smolenski
    International Journal of Molecular Sciences.2022; 23(17): 9886.     CrossRef
  • Lipoprotein Lipase: Is It a Magic Target for the Treatment of Hypertriglyceridemia
    Joon Ho Moon, Kyuho Kim, Sung Hee Choi
    Endocrinology and Metabolism.2022; 37(4): 575.     CrossRef
  • Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Metabolism.2022; 137: 155327.     CrossRef
  • Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies
    Veronika Vyletelová, Mária Nováková, Ľudmila Pašková
    Pharmaceuticals.2022; 15(10): 1278.     CrossRef
  • Cardiovascular Risk Profile and Lipid Management in the Population-Based Cohort Study LATINO: 20 Years of Real-World Data
    Cristina Gavina, Daniel Seabra Carvalho, Marisa Pardal, Marta Afonso-Silva, Diana Grangeia, Ricardo Jorge Dinis-Oliveira, Francisco Araújo, Tiago Taveira-Gomes
    Journal of Clinical Medicine.2022; 11(22): 6825.     CrossRef
  • New and Emerging lipid-lowering Therapy
    James M Backes, Daniel E Hilleman
    Future Cardiology.2021; 17(8): 1407.     CrossRef
  • Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
    Styliani Fragki, Hubert Dirven, Tony Fletcher, Bettina Grasl-Kraupp, Kristine Bjerve Gützkow, Ron Hoogenboom, Sander Kersten, Birgitte Lindeman, Jochem Louisse, Ad Peijnenburg, Aldert H. Piersma, Hans M. G. Princen, Maria Uhl, Joost Westerhout, Marco J. Z
    Critical Reviews in Toxicology.2021; 51(2): 141.     CrossRef
  • A network pharmacology analysis on drug‐like compounds from Ganoderma lucidum for alleviation of atherosclerosis
    Ki Kwang Oh, Md. Adnan, Dong Ha Cho
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Efficacy and Safety of Fenofibrate-Statin Combination Therapy in Patients With Inadequately Controlled Triglyceride Levels Despite Previous Statin Monotherapy: A Multicenter, Randomized, Double-blind, Phase IV Study
    Myung Soo Park, Jong-Chan Youn, Eung Ju Kim, Ki Hoon Han, Sang Hak Lee, Sung Hea Kim, Byung Jin Kim, Sung Uk Kwon, Kyu-Hyung Ryu
    Clinical Therapeutics.2021; 43(10): 1735.     CrossRef
  • Prevalence of and Factors Associated With the Prescription of Fibrates Among Patients Receiving Lipid-Lowering Drugs in Germany
    Louis Jacob, Roger-Axel Greiner, Mark Luedde, Karel Kostev
    Journal of Cardiovascular Pharmacology.2021; 78(6): 885.     CrossRef
  • Challenging Issues in the Management of Cardiovascular Risk Factors in Diabetes During the COVID-19 Pandemic: A Review of Current Literature
    Leili Rahimi, Mojtaba Malek, Faramarz Ismail-Beigi, Mohammad E. Khamseh
    Advances in Therapy.2020; 37(8): 3450.     CrossRef
  • Treatment With Gemfibrozil Prevents the Progression of Chronic Kidney Disease in Obese Dahl Salt-Sensitive Rats
    Corbin A. Shields, Bibek Poudel, Kasi C. McPherson, Andrea K. Brown, Ubong S. Ekperikpe, Evan Browning, Lamari Sutton, Denise C. Cornelius, Jan M. Williams
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes
    Amelia Charlton, Jessica Garzarella, Karin A. M. Jandeleit-Dahm, Jay C. Jha
    Biology.2020; 10(1): 18.     CrossRef
Original Article
Basic Research
Article image
Notch1 Has an Important Role in β-Cell Mass Determination and Development of Diabetes
Young Sil Eom, A-Ryeong Gwon, Kyung Min Kwak, Jin-Young Youn, Heekyoung Park, Kwang-Won Kim, Byung-Joon Kim
Diabetes Metab J. 2021;45(1):86-96.   Published online February 26, 2020
DOI: https://doi.org/10.4093/dmj.2019.0160
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Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Notch signaling pathway plays an important role in regulating pancreatic endocrine and exocrine cell fate during pancreas development. Notch signaling is also expressed in adult pancreas. There are few studies on the effect of Notch on adult pancreas. Here, we investigated the role of Notch in islet mass and glucose homeostasis in adult pancreas using Notch1 antisense transgenic (NAS).

Methods

Western blot analysis was performed for the liver of 8-week-old male NAS mice. We also conducted an intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test in 8-week-old male NAS mice and male C57BL/6 mice (control). Morphologic observation of pancreatic islet and β-cell was conducted in two groups. Insulin secretion capacity in islets was measured by glucose-stimulated insulin secretion (GSIS) and perifusion.

Results

NAS mice showed higher glucose levels and lower insulin secretion in IPGTT than the control mice. There was no significant difference in insulin resistance. Total islet and β-cell masses were decreased in NAS mice. The number of large islets (≥250 µm) decreased while that of small islets (<250 µm) increased. Reduced insulin secretion was observed in GSIS and perifusion. Neurogenin3, neurogenic differentiation, and MAF bZIP transcription factor A levels increased in NAS mice.

Conclusion

Our study provides that Notch1 inhibition decreased insulin secretion and decreased islet and β-cell masses. It is thought that Notch1 inhibition suppresses islet proliferation and induces differentiation of small islets. In conclusion, Notch signaling pathway may play an important role in β-cell mass determination and diabetes.

Citations

Citations to this article as recorded by  
  • The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight
    Elena Klyosova, Iuliia Azarova, Irina Petrukhina, Ramis Khabibulin, Alexey Polonikov
    International Journal of Obesity.2024; 48(11): 1638.     CrossRef
  • Identification of Immune Gene Signature Associated with T Cells and Natural Killer Cells in Type 1 Diabetes
    Na Wang, Guofeng Wang, Xiuli Feng, Teng Yang
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2983.     CrossRef
  • N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway
    Ying Cai, Tao Chen, Mingzhu Wang, Lihua Deng, Cui Li, Siqian Fu, Kangling Xie
    Diabetes Research and Clinical Practice.2023; 197: 110261.     CrossRef
  • Single‐cell RNA sequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia
    Yunqian Yao, Ling Wei, Zhenhua Chen, Hao Li, Jiao Qi, Qingfeng Wu, Xingtao Zhou, Yi Lu, Xiangjia Zhu
    Cell Proliferation.2023;[Epub]     CrossRef
  • Micro ribonucleic acid‐363 regulates the phosphatidylinositol 3‐kinase/threonine protein kinase axis by targeting NOTCH1 and forkhead box C2, leading to hepatic glucose and lipids metabolism disorder in type 2 diabetes mellitus
    Yu‐Huan Peng, Ping Wang, Xiao‐Qun He, Ming‐Zhao Hong, Feng Liu
    Journal of Diabetes Investigation.2022; 13(2): 236.     CrossRef
  • Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling
    Tomonori Okita, Shunbun Kita, Shiro Fukuda, Keita Fukuoka, Emi Kawada-Horitani, Masahito Iioka, Yuto Nakamura, Yuya Fujishima, Hitoshi Nishizawa, Dan Kawamori, Taka-aki Matsuoka, Maeda Norikazu, Iichiro Shimomura
    iScience.2022; 25(11): 105404.     CrossRef
  • Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture
    Kyungmin Kwak, Jae‐kyung Park, Joohyun Shim, Nayoung Ko, Hyoung‐Joo Kim, Yongjin Lee, Jun‐Hyeong Kim, Michael Alexander, Jonathan R. T. Lakey, Hyunil Kim, Kimyung Choi
    Xenotransplantation.2021;[Epub]     CrossRef
  • Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas
    Adem Y. Dawed, Sook Wah Yee, Kaixin Zhou, Nienke van Leeuwen, Yanfei Zhang, Moneeza K. Siddiqui, Amy Etheridge, Federico Innocenti, Fei Xu, Josephine H. Li, Joline W. Beulens, Amber A. van der Heijden, Roderick C. Slieker, Yu-Chuan Chang, Josep M. Mercade
    Diabetes Care.2021; 44(12): 2673.     CrossRef
Reviews
Obesity and Metabolic Syndrome
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Jessica M. Ferrell, John Y. L. Chiang
Diabetes Metab J. 2019;43(3):257-272.   Published online June 13, 2019
DOI: https://doi.org/10.4093/dmj.2019.0043
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AbstractAbstract PDFPubReader   

Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by  
  • Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders
    Nitu L. Wankhede, Mayur B. Kale, Ashishkumar Kyada, Rekha M M, Kamlesh Chaudhary, K.Satyam Naidu, Sandip Rahangdale, Prajwali V. Shende, Brijesh G. Taksande, Mohammad Khalid, Monica Gulati, Milind J. Umekar, Mohammad Fareed, Spandana Rajendra Kopalli, Sus
    Neuroscience.2025; 565: 99.     CrossRef
  • Host metabolism balances microbial regulation of bile acid signalling
    Tae Hyung Won, Mohammad Arifuzzaman, Christopher N. Parkhurst, Isabella C. Miranda, Bingsen Zhang, Elin Hu, Sanchita Kashyap, Jeffrey Letourneau, Wen-Bing Jin, Yousi Fu, Douglas V. Guzior, Randy Longman, Gregory F. Sonnenberg, Ellen Scherl, Robbyn Sockolo
    Nature.2025;[Epub]     CrossRef
  • Gut microbiome-derived secondary bile acids: therapeutic targets for reducing cardiovascular disease in type 2 diabetes?
    Sarah A. Johnson, Tiffany L. Weir
    The American Journal of Clinical Nutrition.2024; 119(2): 241.     CrossRef
  • Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: A systematic review
    Soumik Das, V Devi Rajeswari, Ganesh Venkatraman, Ramprasad Elumalai, Sivaraman Dhanasekaran, Gnanasambandan Ramanathan
    Translational Research.2024; 265: 71.     CrossRef
  • The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
    Yuchang Li, Liting Chen, Vassilios Papadopoulos
    Biochimie.2024; 224: 91.     CrossRef
  • Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes
    Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A. Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M. Rebholz, Tao Wang, Carmen R. Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D. Burk, Rober
    Nature Metabolism.2024; 6(1): 169.     CrossRef
  • Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a prospective cohort study
    Wen Wen, Qinze Li, Jianqing She, Xiaofang Bai, Lisha Zhang, Ruifeng Li, Yan Wu, Juan Zhou, Zuyi Yuan
    Scientific Reports.2024;[Epub]     CrossRef
  • Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism
    John C. Rowe, Jenessa A. Winston
    Veterinary Sciences.2024; 11(2): 94.     CrossRef
  • The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
    Olga Golubnitschaja, Jiri Polivka, Pavel Potuznik, Martin Pesta, Ivana Stetkarova, Alena Mazurakova, Lenka Lackova, Peter Kubatka, Martina Kropp, Gabriele Thumann, Carl Erb, Holger Fröhlich, Wei Wang, Babak Baban, Marko Kapalla, Niva Shapira, Kneginja Ric
    EPMA Journal.2024; 15(1): 1.     CrossRef
  • Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats
    Yadi Hou, Yanmei Huang, Zihui Shang, Shichao Ma, Tianyi Cui, Ali Chen, Yongxia Cui, Suiqing Chen
    Journal of Ethnopharmacology.2024; 328: 118065.     CrossRef
  • Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders
    Bandar D. Alrehaili
    Saudi Journal of Gastroenterology.2024; 30(5): 283.     CrossRef
  • Cichorium glandulosum Ameliorates HFD-Induced Obesity in Mice by Modulating Gut Microbiota and Bile Acids
    Yewei Zhong, Hurxida Emam, Wenhui Hou, Junlin Yan, Adalaiti Abudurexiti, Rui Zhang, Shuwen Qi, Yi Lei, Xiaoli Ma
    Journal of Medicinal Food.2024; 27(7): 601.     CrossRef
  • Exercise Training Independent of Intensity Lowers Plasma Bile Acids in Prediabetes
    STEVEN K. MALIN, U.S. AFSHEEN SYEDA
    Medicine & Science in Sports & Exercise.2024; 56(6): 1009.     CrossRef
  • Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism
    Annika Wahlström, Ariel Brumbaugh, Wilhelm Sjöland, Lisa Olsson, Hao Wu, Marcus Henricsson, Annika Lundqvist, Kassem Makki, Stanley L. Hazen, Göran Bergström, Hanns-Ulrich Marschall, Michael A. Fischbach, Fredrik Bäckhed
    Nature Communications.2024;[Epub]     CrossRef
  • Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases
    Yanyan Wang, Huangru Xu, Xiqiao Zhou, Weidong Chen, Huiping Zhou
    Medical Review.2024; 4(4): 262.     CrossRef
  • A Mixture of Lactobacillus HY7601 and KY1032 Regulates Energy Metabolism in Adipose Tissue and Improves Cholesterol Disposal in High-Fat-Diet-Fed Mice
    Kippeum Lee, Hyeon-Ji Kim, Joo-Yun Kim, Jae-Jung Shim, Jae-Hwan Lee
    Nutrients.2024; 16(15): 2570.     CrossRef
  • Pathophysiological Relationship between Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Therapeutic Approaches
    Shifat-E Ferdous, Jessica M. Ferrell
    International Journal of Molecular Sciences.2024; 25(16): 8731.     CrossRef
  • An efficient regioconvergent synthesis of 3-aza-obeticholic acid
    Lawrence D. Harris, Roselis A. Landaeta Aponte, Wanting Jiao, Scott A. Cameron, Alex Weymouth-Wilson, Richard H. Furneaux, Benjamin J. Compton, Andreas Luxenburger
    Steroids.2024; 212: 109517.     CrossRef
  • A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents
    Bantayehu Addis Tegegne, Adane Adugna, Aderaw Yenet, Wubetu Yihunie Belay, Yared Yibeltal, Abebe Dagne, Zigale Hibstu Teffera, Gashaw Azanaw Amare, Desalegn Abebaw, Haymanot Tewabe, Rahel Belete Abebe, Tirsit Ketsela Zeleke
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes
    Marina Hernández-Martín, Alba Garcimartín, Aránzazu Bocanegra, Adrián Macho-González, Rosa A. García-Fernández, Sonia de Pascual-Teresa, Rocío Redondo-Castillejo, Sara Bastida, Francisco J. Sánchez-Muniz, Juana Benedí, Mª Elvira López-Oliva
    International Journal of Molecular Sciences.2024; 25(21): 11405.     CrossRef
  • Unveiling Role of Serum Total Bile Acid in Diabetic Osteopathy, the Unexplored Complication of Diabetes
    Mantu Jain, Chhabi Rani Panda, Paulson Varghese, Saurav Nayak, Sujit Tripathy, Gautom Kumar Saharia, Manaswini Mangaraj
    Indian Journal of Clinical Biochemistry.2024;[Epub]     CrossRef
  • Regulation of bile acids and their receptor FXR in metabolic diseases
    Yao Li, Lulu Wang, Qing Yi, Linsong Luo, Yuxia Xiong
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Editorial: Bile acids in obesity-related diseases
    Yun Shen, Xiaojiao Zheng, Ying Hu, Youping Deng, Qin Xiong
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Improvement of myocardial injury and gut microbiota disturbance in type 2 diabetic mice by inulin with various degrees of polymerization
    Siqiang Jia, Jianpeng Li, Bin Yu, Mengjie Li, Bo Cui
    Food Bioscience.2023; 51: 102318.     CrossRef
  • Bile acids and their receptors in regulation of gut health and diseases
    Sen Lin, Sutian Wang, Peng Wang, Cuiming Tang, Zhenjiang Wang, Lian Chen, Guoqing Luo, Hong Chen, Yuntao Liu, Bin Feng, De Wu, Douglas G. Burrin, Zhengfeng Fang
    Progress in Lipid Research.2023; 89: 101210.     CrossRef
  • Effects of dietary oat supplementation on carcass traits, muscle metabolites, amino acid profiles, and its association with meat quality of Small-tail Han sheep
    Li-wei Wang, Shao-feng Su, Jie Zhao, Xiao-long He, Shao-yin Fu, Biao Wang, Yun-fei Wang, Da-qing Wang, Na-na Yun, Xin Chen, Damien P Belobrajdic, Terigele, Xiao-dong Li, Li-li Jiang, Jiang-feng He, Yong-bin Liu
    Food Chemistry.2023; 411: 135456.     CrossRef
  • Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism
    Wenjing Mo, Jiaqi Zou, Ming Wu, Zijun Peng, Wenjiang He, Wenzhi Li, Xiaoyong Wu
    Journal of Functional Foods.2023; 101: 105408.     CrossRef
  • Sodium glucose co-transporter 2 (SGLT2) inhibition via dapagliflozin improves diabetic kidney disease (DKD) over time associatied with increasing effect on the gut microbiota in db/db mice
    Jiajia Wu, Yan Chen, Huinan Yang, Leyi Gu, Zhaohui Ni, Shan Mou, Jianxiao Shen, Xiajing Che
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Short communication: unique metabolic signature of proliferative retinopathy in the tear fluid of diabetic patients with comorbidities — preliminary data for PPPM validation
    Martina Kropp, Eline De Clerck, Trong-Tin Kevin Steve Vo, Gabriele Thumann, Vincenzo Costigliola, Olga Golubnitschaja
    EPMA Journal.2023; 14(1): 43.     CrossRef
  • Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice
    Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, Kiyoshi Takatsu, Kazuyuki Tobe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
    International Journal of Molecular Sciences.2023; 24(4): 4050.     CrossRef
  • Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis
    Genta Kakiyama, Daniel Rodriguez-Agudo, William M. Pandak
    Cells.2023; 12(10): 1434.     CrossRef
  • Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
    Kevin M. Tveter, Esther Mezhibovsky, Yue Wu, Diana E. Roopchand
    Pharmacology & Therapeutics.2023; 248: 108457.     CrossRef
  • Role of liver parameters in diabetes mellitus – a narrative review
    Sana Rafaqat, Aqsa Sattar, Amber Khalid, Saira Rafaqat
    Endocrine Regulations.2023; 57(1): 200.     CrossRef
  • Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
    Ewa Oleszycka, Eoin C. O’Brien, Michael Freeley, Ed C. Lavelle, Aideen Long
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Machine learning for predicting diabetic metabolism in the Indian population using polar metabolomic and lipidomic features
    Nikita Jain, Bhaumik Patel, Manjesh Hanawal, Anurag R. Lila, Saba Memon, Tushar Bandgar, Ashutosh Kumar
    Metabolomics.2023;[Epub]     CrossRef
  • Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
    Ahmad Salhab, Johnny Amer, Yinying Lu, Rifaat Safadi
    Gut.2022; 71(7): 1373.     CrossRef
  • Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet
    Nan Hu, Qi Zhang, Hui Wang, Xuping Yang, Yan Jiang, Rong Chen, Liying Wang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Immunomodulatory functions of FXR
    Stefano Fiorucci, Angela Zampella, Patrizia Ricci, Eleonora Distrutti, Michele Biagioli
    Molecular and Cellular Endocrinology.2022; 551: 111650.     CrossRef
  • Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota
    Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova
    Biomolecules.2022; 12(5): 687.     CrossRef
  • Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus
    liying he, Fang-Qing Yang, Pan Tang, Ting-Hui Gao, Cai-Xia Yang, Li Tan, Pan Yue, Ya-Nan Hua, Si-Jing Liu, Jin-Lin Guo
    Biomedicine & Pharmacotherapy.2022; 151: 113091.     CrossRef
  • Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosis and changed bile acids metabolism
    Zonghao Yue, Yanjuan Chen, Qian Dong, Dan Li, Meng Guo, Li Zhang, Yini Shi, Huiting Wu, Lili Li, Zhongke Sun
    Food Research International.2022; 157: 111405.     CrossRef
  • Effects of Herbal Therapy on Intestinal Microbiota and Serum Metabolomics in Different Rat Models of Mongolian Medicine
    Guniang Jiu, Riao Dao, Dongxing Wu, Wang Hung, Haburi Jin, Li Li, Xiquan Fu, Chula Sa, Eerdunchaolu, Maulidiani .M
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors
    Tomonori Kamiya, Naoko Ohtani
    International Immunology.2022; 34(9): 467.     CrossRef
  • Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study
    Armin Mooranian, Jacqueline Chester, Edan Johnston, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Momir Mikov, Hani Al-Salami
    Biomolecules.2022; 12(7): 877.     CrossRef
  • Crisis of the Asian gut: associations among diet, microbiota, and metabolic diseases
    Phatthanaphong THERDTATHA, Akari SHINODA, Jiro NAKAYAMA
    Bioscience of Microbiota, Food and Health.2022; 41(3): 83.     CrossRef
  • Valorization of avocado seeds with antioxidant capacity using pressurized hot water extraction
    Eng Shi Ong, Janelle Low, Joseph Choon Wee Tan, Su Yi Foo, Chen Huei Leo
    Scientific Reports.2022;[Epub]     CrossRef
  • The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice
    Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian, Yuanxiang Jin
    Chemosphere.2022; 307: 136141.     CrossRef
  • Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study
    Yueh-Hsiang Huang, Yi-Hong Wu, Hsiang-Yu Tang, Szu-Tah Chen, Chih-Ching Wang, Wan-Jing Ho, Yi-Hsuan Lin, Geng-Hao Liu, Pei-Yeh Lin, Chi-Jen Lo, Yuan-Ming Yeh, Mei-Ling Cheng
    Pharmaceutics.2022; 14(9): 1857.     CrossRef
  • Gut–Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome
    Salvatore Pezzino, Maria Sofia, Gloria Faletra, Chiara Mazzone, Giorgia Litrico, Gaetano La Greca, Saverio Latteri
    Biology.2022; 11(11): 1622.     CrossRef
  • The Role of Bile Acids in Cardiovascular Diseases: from Mechanisms to Clinical Implications
    Shuwen Zhang, Junteng Zhou, Wenchao Wu, Ye Zhu, Xiaojing Liu
    Aging and disease.2022;[Epub]     CrossRef
  • Role of bile acids in overweight and obese children and adolescents
    Cosimo Giannini, Concetta Mastromauro, Serena Scapaticci, Cristina Gentile, Francesco Chiarelli
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Bile acids and microbes in metabolic disease
    Dhiraj Kumar Sah, Archana Arjunan, Sun Young Park, Young Do Jung
    World Journal of Gastroenterology.2022; 28(48): 6846.     CrossRef
  • The Fungicide Prothioconazole and its Metabolite Prothioconazole-Desthio Disturbed the Liver-Gut Axis in Mice
    Yuanxiang Jin, Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The Critical Effect of Bile Acids in Atherosclerosis
    Shangwen Qi, Xu Luo, Shuangfang Liu, Bishi Ling, Hua Jin
    Journal of Cardiovascular Pharmacology.2022; 80(4): 562.     CrossRef
  • Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
    Ye-Jee Lee, Esder Lee, Young-Hye You, Yu-Bae Ahn, Ki-Ho Song, Ji-Won Kim, Seung-Hyun Ko
    Journal of Drug Targeting.2021; 29(1): 88.     CrossRef
  • Impact of gut microbiota: How it could play roles beyond the digestive system on development of cardiovascular and renal diseases
    Kanmani Suganya, Taekwon Son, Kyu-Won Kim, Byung-Soo Koo
    Microbial Pathogenesis.2021; 152: 104583.     CrossRef
  • Determination of bile acids from human gallbladder by 1H‐MRS—Protocol optimization and estimation of reproducibility
    Peter Vermathen, Gaëlle Diserens, Dino Kröll, Philipp Nett, Guido Stirnimann, Reiner Wiest
    NMR in Biomedicine.2021;[Epub]     CrossRef
  • The gut microbiome-bile acid axis in hepatocarcinogenesis
    Liwei Wu, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
    Biomedicine & Pharmacotherapy.2021; 133: 111036.     CrossRef
  • Gut microbiome and bile acids in obesity-related diseases
    Rumei Li, Sergio Andreu-Sánchez, Folkert Kuipers, Jingyuan Fu
    Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(3): 101493.     CrossRef
  • Gut Microbiome of Indonesian Adults Associated with Obesity and Type 2 Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta
    Phatthanaphong Therdtatha, Yayi Song, Masaru Tanaka, Mariyatun Mariyatun, Maisaroh Almunifah, Nancy Eka Putri Manurung, Siska Indriarsih, Yi Lu, Koji Nagata, Katsuya Fukami, Tetsuo Ikeda, Yuan-Kun Lee, Endang Sutriswati Rahayu, Jiro Nakayama
    Microorganisms.2021; 9(5): 897.     CrossRef
  • Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
    Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 1841.     CrossRef
  • Role of bile acids in inflammatory liver diseases
    Ioannis Evangelakos, Joerg Heeren, Esther Verkade, Folkert Kuipers
    Seminars in Immunopathology.2021; 43(4): 577.     CrossRef
  • Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
    Alessandro Mantovani, Andrea Dalbeni, Denise Peserico, Filippo Cattazzo, Michele Bevilacqua, Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Elisa Danese, Cristiano Fava
    Metabolites.2021; 11(7): 453.     CrossRef
  • Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice
    Xue-Song Zhang, Yue Sandra Yin, Jincheng Wang, Thomas Battaglia, Kimberly Krautkramer, Wei Vivian Li, Jackie Li, Mark Brown, Meifan Zhang, Michelle H. Badri, Abigail J.S. Armstrong, Christopher M. Strauch, Zeneng Wang, Ina Nemet, Nicole Altomare, Joseph C
    Cell Host & Microbe.2021; 29(8): 1249.     CrossRef
  • Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature
    Sarah Kim, Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken, Frank J. Gonzalez, Julia Yue Cui, Maxwell A. Gyamfi
    Biochemical Pharmacology.2021; 193: 114698.     CrossRef
  • Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products
    Fan Xia, Lu-Ping Wen, Bing-Chen Ge, Yu-Xin Li, Fang-Ping Li, Ben-Jie Zhou
    World Journal of Diabetes.2021; 12(8): 1146.     CrossRef
  • Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus
    Youngae Jung, Bo Kyung Koo, Seo Young Jang, Dain Kim, Heeyeon Lee, Dong Hyeon Lee, Sae Kyung Joo, Yong Jin Jung, Jeong Hwan Park, Taekyeong Yoo, Murim Choi, Min Kyung Lee, Sang Won Kang, Mee Soo Chang, Won Kim, Geum‐Sook Hwang
    Liver International.2021; 41(12): 2892.     CrossRef
  • Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease
    Michele Biagioli, Stefano Fiorucci
    Liver Research.2021; 5(3): 119.     CrossRef
  • Synthesis of 12β-Methyl-18-nor-bile Acids
    Andreas Luxenburger, Lawrence D. Harris, Elizabeth M. Ure, Roselis A. Landaeta Aponte, Anthony D. Woolhouse, Scott A. Cameron, Chris D. Ling, Ross O. Piltz, Andrew R. Lewis, Graeme J. Gainsford, Alex Weymouth-Wilson, Richard H. Furneaux
    ACS Omega.2021; 6(38): 25019.     CrossRef
  • Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification
    Kamil Borkowski, Ameer Y. Taha, Theresa L. Pedersen, Philip L. De Jager, David A. Bennett, Matthias Arnold, Rima Kaddurah-Daouk, John W. Newman
    Scientific Reports.2021;[Epub]     CrossRef
  • Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids
    Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)
    Xian Wei, Ting Yao, Fatou Ndoye Fall, Min Xue, Xiaofang Liang, Jie Wang, Wenlong Du, Xu Gu
    Foods.2021; 10(10): 2465.     CrossRef
  • Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
    Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim, Ji Hye Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids
    Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu, Xuebo Liu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(11): 165908.     CrossRef
  • Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
    Yingjie Wu, An Zhou, Li Tang, Yuanyuan Lei, Bo Tang, Linjing Zhang
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
    John Y. L. Chiang, Jessica M. Ferrell
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 318(3): G554.     CrossRef
  • Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice
    Guiling Yang, Xianling Yuan, Cuiyuan Jin, Dou Wang, Yanhua Wang, Wenyu Miao, Yuanxiang Jin
    Environmental Pollution.2020; 266: 115290.     CrossRef
  • Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
    John Y.L. Chiang, Jessica M. Ferrell
    Liver Research.2020; 4(2): 47.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • Healthy dietary patterns to reduce obesity-related metabolic disease: polyphenol-microbiome interactions unifying health effects across geography
    Camilla Diotallevi, Francesca Fava, Marco Gobbetti, Kieran Tuohy
    Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(6): 437.     CrossRef
  • Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery
    Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum, Mohamed A. Elrayess
    Journal of Translational Medicine.2020;[Epub]     CrossRef
  • Quantification of common and planar bile acids in tissues and cultured cells
    Stephanie J. Shiffka, Jace W. Jones, Linhao Li, Ann M. Farese, Thomas J. MacVittie, Hongbing Wang, Peter W. Swaan, Maureen A. Kane
    Journal of Lipid Research.2020; 61(11): 1524.     CrossRef
  • Influência da microbiota intestinal na Doença Hepática Gordurosa Não Alcoólica
    Isadora Barbosa de Almeida, Wermerson Assunção Barroso, Caroline Amélia Gonçalves
    Revista Científica Multidisciplinar Núcleo do Conhecimento.2020; : 14.     CrossRef
  • Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients
    Adriana Florinela Cӑtoi, Alina Elena Pârvu, Aurel Mironiuc, Horațiu Silaghi, Ioana Delia Pop, Andra Diana Andreicuț
    Medicina.2019; 55(12): 757.     CrossRef
Pathophysiology
Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
Jae Man Lee
Diabetes Metab J. 2017;41(1):10-19.   Published online February 16, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.1.10
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AbstractAbstract PDFPubReader   

Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have emerged as potential treatments for insulin resistance. The mechanistic basis for these antidiabetic effects has primarily been attributed to multiple metabolic and inflammatory functions. Here we review recent advances in our understanding of the association of ER stress with insulin resistance and the role of nuclear receptors in promoting ER stress resolution and improving insulin resistance in the liver.

Citations

Citations to this article as recorded by  
  • Ancient Secretory Pathways Contributed to the Evolutionary Origin of an Ecologically Impactful Bioluminescence System
    Lisa Y Mesrop, Geetanjali Minsky, Michael S Drummond, Jessica A Goodheart, Stephen R Proulx, Todd H Oakley, Belinda Chang
    Molecular Biology and Evolution.2024;[Epub]     CrossRef
  • Duality of Nrf2 in iron-overload cardiomyopathy
    Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Matte, Serge Cedrick Mbiandjeu Toya, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, Steven Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Manuela Iezzi, Alessia
    Haematologica.2023; 108(5): 1335.     CrossRef
  • Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated
    Gyuhui Kim, Jiyoon Lee, Joohun Ha, Insug Kang, Wonchae Choe
    Nutrients.2023; 15(24): 5082.     CrossRef
  • Qingluotongbi formula regulates the LXRα-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by Tripterygium wilfordii Hook. f.
    Zhichao Yu, Zhe Feng, Ling Fu, Jing Wang, Changqing Li, Huaxu Zhu, Tong Xie, Jie Zhou, Lingling Zhou, Xueping Zhou
    Journal of Ethnopharmacology.2022; 287: 114952.     CrossRef
  • Nuclear‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer
    Svenja Michalek, Thomas Brunner
    IUBMB Life.2021; 73(3): 592.     CrossRef
  • NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity
    Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan
    Journal of Biological Chemistry.2021; 296: 100624.     CrossRef
  • Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress
    Chunjie Jiang, Shanshan Zhang, Dan Li, Li Chen, Ying Zhao, Guibin Mei, Jingjing Liu, Yuhan Tang, Chao Gao, Ping Yao
    Food and Chemical Toxicology.2020; 140: 111329.     CrossRef
  • Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression
    Minyoung Lee, Eugene Shin, Jaehyun Bae, Yongin Cho, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Scientific Reports.2020;[Epub]     CrossRef
  • Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study
    Nam Hoon Kim, Ki Hoon Han, Jimi Choi, Juneyoung Lee, Sin Gon Kim
    BMJ.2019; : l5125.     CrossRef
  • Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity—Short Communication
    Michalina Alicka, Katarzyna Kornicka-Garbowska, Michael Roecken, Krzysztof Marycz
    International Journal of Molecular Sciences.2019; 20(23): 5873.     CrossRef
  • Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction
    Udayakumar Karunakaran, Ji Eun Lee, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Free Radical Biology and Medicine.2019; 141: 59.     CrossRef
  • Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
    Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
    Diabetologia.2019; 62(5): 779.     CrossRef
  • CCAAT/enhancer binding protein homologous protein knockdown alleviates hypoxia-induced myocardial injury in rat cardiomyocytes exposed to high glucose
    Wenqi Yang, Fang Wu, Ting Luo, Yuelan Zhang
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate
    Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jiang
    Food and Chemical Toxicology.2017; 110: 325.     CrossRef
Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes
Timothy S. Kern
Diabetes Metab J. 2014;38(3):163-170.   Published online June 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.3.163
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AbstractAbstract PDFPubReader   

For years, diabetic retinopathy has been defined based on vascular lesions, and neural abnormalities were not regarded as important. This review summarizes evidence that the neural retina has important effects on the retinal vasculature under normal conditions, and the interaction between the retinal neuroglial cells and vascular function is altered in diabetes. Importantly, new evidence raises a possibility that abnormalities within retinal neuroglial cells (notably photoreceptors) might actually be causing or initiating the vascular disease in diabetic retinopathy.

Citations

Citations to this article as recorded by  
  • Cellular and Molecular Mechanisms of Neuronal Degeneration in Early-Stage Diabetic Retinopathy
    Andrew Callan, Sonal Jha, Laura Valdez, Andrew Tsin
    Current Vascular Pharmacology.2024; 22(5): 301.     CrossRef
  • Thioredoxin 1 overexpression attenuated diabetes‐induced endoplasmic reticulum stress in Müller cells via apoptosis signal‐regulating kinase 1
    Xuebin Yu, Qiufeng Teng, Kaimin Bao, Maryam Chudhary, Hui Qi, Wenying Zhou, Hongxin Che, Junli Liu, Xiang Ren, Li Kong
    Journal of Cellular Biochemistry.2023; 124(3): 421.     CrossRef
  • Visual acuity changes associated with foveal ischemia detected by optical coherence tomography angiography in type II diabetic patients without diabetic retinopathy
    Moataz A. Sallam, Mohamed E. Shahin, Esraa A. Ali
    Delta Journal of Ophthalmology.2023; 24(1): 23.     CrossRef
  • Implications of Diabetes-Induced Altered Metabolites on Retinal Neurodegeneration
    Dalia I. Aldosari, Ajamaluddin Malik, Abdullah S. Alhomida, Mohammad S. Ola
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy
    Drake W. Lem, Dennis L. Gierhart, Pinakin Gunvant Davey
    Nutrients.2021; 13(7): 2441.     CrossRef
  • Bioactive Compound and Nanotechnology: A Novel Delivery Perspective for Diabetic Retinopathy
    Anima Debbarma, Probin Kr Roy, Samia B. Barbhuiya, Jayita Das, Laldinchhana, Hauzel Lalhlenmawia
    Current Bioactive Compounds.2021;[Epub]     CrossRef
  • Looking Ahead: Visual and Anatomical Endpoints in Future Trials of Diabetic Macular Ischemia
    Chui Ming Gemmy Cheung, Elizabeth Pearce, Beau Fenner, Piyali Sen, Victor Chong, Sobha Sivaprasad
    Ophthalmologica.2021; 244(5): 451.     CrossRef
  • Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice
    Fang Liu, Alan B. Saul, Prahalathan Pichavaram, Zhimin Xu, Madhuri Rudraraju, Payaningal R. Somanath, Sylvia B. Smith, Ruth B. Caldwell, S. Priya Narayanan
    Journal of Clinical Medicine.2020; 9(2): 340.     CrossRef
  • Targeting Neurovascular Interaction in Retinal Disorders
    Zhongjie Fu, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang, Zhongxiao Wang, Chi-Hsiu Liu, Steve S. Cho, William Britton, Timothy S. Kern, David A. Antonetti, Ann Hellström, Lois E.H. Smith
    International Journal of Molecular Sciences.2020; 21(4): 1503.     CrossRef
  • Glycine receptor is differentially expressed in the rat retina at early stages of streptozotocin-induced diabetes
    Elizabeth Morales-Calixto, Miguel Ángel Velázquez-Flores, Gustavo Sánchez-Chávez, Ruth Ruiz Esparza-Garrido, Rocío Salceda
    Neuroscience Letters.2019; 712: 134506.     CrossRef
  • Effect of Autophagy Modulators on Vascular, Glial, and Neuronal Alterations in the Oxygen-Induced Retinopathy Mouse Model
    Paula V. Subirada, María C. Paz, Magali E. Ridano, Valeria E. Lorenc, Claudio M. Fader, Gustavo A. Chiabrando, María C. Sánchez
    Frontiers in Cellular Neuroscience.2019;[Epub]     CrossRef
  • Retinal Sensitivity Loss Correlates with Deep Capillary Plexus Impairment in Diabetic Macular Ischemia
    Fabio Scarinci, Monica Varano, Mariacristina Parravano
    Journal of Ophthalmology.2019; 2019: 1.     CrossRef
  • Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy
    S. Priya Narayanan, Esraa Shosha, Chithra D Palani
    Pharmacological Research.2019; 147: 104299.     CrossRef
  • Translational research in retinal vascular disease. An approach
    Toke Bek
    Acta Ophthalmologica.2019; 97(5): 441.     CrossRef
  • Protective Effects of Leukemia Inhibitory Factor on Retinal Vasculature and Cells in Streptozotocin-induced Diabetic Mice
    Xiu-Fen Yang, Ying-Xiang Huang, Ming Lan, Tao-Ran Zhang, Jie Zhou
    Chinese Medical Journal.2018; 131(1): 75.     CrossRef
  • SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets
    Maria Vähätupa, Janika Nättinen, Antti Jylhä, Ulla Aapola, Marko Kataja, Peeter Kööbi, Tero A. H. Järvinen, Hannu Uusitalo, Hannele Uusitalo-Järvinen
    Investigative Opthalmology & Visual Science.2018; 59(8): 3294.     CrossRef
  • Association Between Vessel Density and Visual Acuity in Patients With Diabetic Retinopathy and Poorly Controlled Type 1 Diabetes
    Bénédicte Dupas, Wilfried Minvielle, Sophie Bonnin, Aude Couturier, Ali Erginay, Pascale Massin, Alain Gaudric, Ramin Tadayoni
    JAMA Ophthalmology.2018; 136(7): 721.     CrossRef
  • Diabetic macular oedema: clinical risk factors and emerging genetic influences
    Ebony Liu, Jamie E Craig, Kathryn Burdon
    Clinical and Experimental Optometry.2017; 100(6): 569.     CrossRef
  • Comparison of spectral-domain optical coherence tomography for intra-retinal layers thickness measurements between healthy and diabetic eyes among Chinese adults
    Shu-ting Li, Xiang-ning Wang, Xin-hua Du, Qiang Wu, Demetrios G. Vavvas
    PLOS ONE.2017; 12(5): e0177515.     CrossRef
  • RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis
    Ye Sun, Chi‐Hsiu Liu, Zhongxiao Wang, Steven S. Meng, Samuel B. Burnim, John Paul SanGiovanni, Theodore M. Kamenecka, Laura A. Solt, Jing Chen
    The FASEB Journal.2017; 31(10): 4492.     CrossRef
  • Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina
    Dalia Al-Dosari, Mohammed Ahmed, Salim Al-Rejaie, Abdullah Alhomida, Mohammad Ola
    Nutrients.2017; 9(10): 1161.     CrossRef
  • Do photoreceptor cells cause the development of retinal vascular disease?
    Timothy S. Kern
    Vision Research.2017; 139: 65.     CrossRef
  • Putative protective role of lutein and zeaxanthin in diabetic retinopathy
    Kumari Neelam, Catherina J Goenadi, Katherine Lun, Chee Chew Yip, Kah-Guan Au Eong
    British Journal of Ophthalmology.2017; 101(5): 551.     CrossRef
  • Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
    Katherine J Wert, Vinit B Mahajan, Lijuan Zhang, Yuanqing Yan, Yao Li, Joaquin Tosi, Chun Wei Hsu, Takayuki Nagasaki, Kerstin M Janisch, Maria B Grant, MaryAnn Mahajan, Alexander G Bassuk, Stephen H Tsang
    Signal Transduction and Targeted Therapy.2016;[Epub]     CrossRef
  • Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors Reduce Reactive Gliosis and Improve Angiostatin Levels in Retina of Diabetic Rats
    Mykhailo M. Guzyk, Artem A. Tykhomyrov, Victor S. Nedzvetsky, Irina V. Prischepa, Tatiana V. Grinenko, Lesya V. Yanitska, Tamara M. Kuchmerovska
    Neurochemical Research.2016; 41(10): 2526.     CrossRef
  • Neuroprotective actions of progesterone in an in vivo model of retinitis pigmentosa
    V. Sánchez-Vallejo, S. Benlloch-Navarro, R. López-Pedrajas, F.J. Romero, M. Miranda
    Pharmacological Research.2015; 99: 276.     CrossRef
  • Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
    Andrea Matteucci, Monica Varano, Cinzia Mallozzi, Lucia Gaddini, Marika Villa, Sara Gabrielli, Giuseppe Formisano, Flavia Pricci, Fiorella Malchiodi-Albedi
    BioMed Research International.2015; 2015: 1.     CrossRef
  • Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy
    Renu A. Kowluru, Anjan Kowluru, Manish Mishra, Binit Kumar
    Progress in Retinal and Eye Research.2015; 48: 40.     CrossRef
  • Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence
    Rafael Simó, Cristina Hernández
    Progress in Retinal and Eye Research.2015; 48: 160.     CrossRef
  • SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth
    Ye Sun, Meihua Ju, Zhiqiang Lin, Thomas W. Fredrick, Lucy P. Evans, Katherine T. Tian, Nicholas J. Saba, Peyton C. Morss, William T. Pu, Jing Chen, Andreas Stahl, Jean-Sébastien Joyal, Lois E. H. Smith
    Science Signaling.2015;[Epub]     CrossRef
  • Enriched Environment Protects the Optic Nerve from Early Diabetes-Induced Damage in Adult Rats
    Damián Dorfman, Marcos L. Aranda, Ruth E. Rosenstein, Rafael Linden
    PLOS ONE.2015; 10(8): e0136637.     CrossRef
  • Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy
    Lorena Perrone, Carmela Matrone, Lalit P. Singh
    Journal of Ophthalmology.2014; 2014: 1.     CrossRef
Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity
Cesar Corzo, Patrick R. Griffin
Diabetes Metab J. 2013;37(6):395-403.   Published online December 12, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.6.395
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AbstractAbstract PDFPubReader   

Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.

Citations

Citations to this article as recorded by  
  • Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification
    Yucheng Fan, Fangjing Xu, Rui Wang, Jun He
    Scientific Reports.2023;[Epub]     CrossRef
  • Heart failure and diabetes: Clinical significance and epidemiology of this two‐way association
    Terri Jerkins, Janet B. McGill, David S. H. Bell
    Diabetes, Obesity and Metabolism.2023; 25(S3): 3.     CrossRef
  • The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics
    Gargi Dixit, Arati Prabhu
    Experimental and Molecular Pathology.2022; 124: 104723.     CrossRef
  • The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis
    Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Sui-Lung Su
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
    Hyunmi Kim, Da Som Lee, Tae Hyeon An, Hyun-Ju Park, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh
    International Journal of Molecular Sciences.2021; 22(9): 4495.     CrossRef
  • Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study
    P. Nakandakare, C. F. Nicoletti, N. Y. Noronha, C. B. Nonino, P. P. Argentato, N. N. Dejani, L. A. Luzia, M. M. Rogero, P. H. C. Rondó
    International Journal of Obesity.2021; 45(9): 1958.     CrossRef
  • PPARG Pro12Ala Polymorphism with CKD in Asians: A Meta-Analysis Combined with a Case-Control Study—A Key for Reaching Null Association
    Hsiang-Cheng Chen, Wei-Teing Chen, Tzu-Ling Sung, Dung-Jang Tsai, Chin Lin, Hao Su, Yuh-Feng Lin, Hung-Yi Chiu, Sui-Lung Su
    Genes.2020; 11(6): 705.     CrossRef
  • Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
    Mebrahtom Gebrelibanos Hiben, Laura de Haan, Bert Spenkelink, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens
    BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
  • UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis
    Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
    Clinical Science.2020; 134(14): 1911.     CrossRef
  • Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
    Ioannis Koutroulis, Rachael Batabyal, Brittany McNamara, Matthew Ledda, Claire Hoptay, Robert J. Freishtat
    Critical Care Explorations.2019; 1(11): e0061.     CrossRef
  • Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus
    Eugene Han, Eugene Shin, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Role of oral hypoglycemic drugs on inflammatory condition associated with type 2 diabetes mellitus
    Shamim Shaikh Mohiuddin
    Journal of Diabetes, Metabolic Disorders & Control.2018; 5(2): 78.     CrossRef
  • Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
    Bong-Hoi Choi, Zhen Jin, Chin-ok Yi, Juhong Oh, Eun Ae Jeong, Jong Youl Lee, Kyung-ah Park, Kyung Eun Kim, Jung Eun Lee, Hyun-Jin Kim, Jong Ryeal Hahm, Gu Seob Roh, Jonathan M Peterson
    PLOS ONE.2018; 13(7): e0200336.     CrossRef
  • Cucurbita ficifolia (Cucurbitaceae) modulates inflammatory cytokines and IFN-γ in obese mice
    Á. Fortis-Barrera, R. García-Macedo, J.C. Almanza-Perez, G. Blancas-Flores, A. Zamilpa-Alvarez, J.L. Flores-Sáenz, M. Cruz, R. Román-Ramos, F.J. Alarcón-Aguilar
    Canadian Journal of Physiology and Pharmacology.2017; 95(2): 170.     CrossRef
  • Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
    Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
    Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
  • Peroxisome proliferator‐activated receptor‐γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
    Brahmchetna Bedi, Nicholas M. Maurice, Vincent T. Ciavatta, K. Sabrina Lynn, Zhihong Yuan, Samuel A. Molina, Myungsoo Joo, William R. Tyor, Joanna B. Goldberg, Michael Koval, C. Michael Hart, Ruxana T. Sadikot
    The FASEB Journal.2017; 31(8): 3608.     CrossRef
  • Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials
    Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren, Jan Westerink
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation
    Shih-Chun Pan, Ching-Chun Huang, Shio-Jean Lin, Bing-Yu Chen, Chang-Chuan Chan, Yue-Liang Leon Guo
    Environmental Research.2017; 158: 318.     CrossRef
  • The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism
    Margherita Maffei, Ilaria Barone, Gaia Scabia, Ferruccio Santini
    Endocrine Reviews.2016; 37(4): 403.     CrossRef
  • Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma
    Brahmchetna Bedi, Zhihong Yuan, Myungsoo Joo, Susu M. Zughaier, Joanna B. Goldberg, Jack L. Arbiser, C. Michael Hart, Ruxana T. Sadikot, B. A. McCormick
    Infection and Immunity.2016; 84(7): 1975.     CrossRef
  • F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
    Kyeong Won Lee, Soo Heon Kwak, Young Do Koo, Yun-Kyung Cho, Hak Mo Lee, Hye Seung Jung, Young Min Cho, Young Joo Park, Sung Soo Chung, Kyong Soo Park
    Experimental & Molecular Medicine.2016; 48(5): e234.     CrossRef
  • The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
    Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • Lobeglitazone and pioglitazone as add‐ons to metformin for patients with type 2 diabetes: a 24‐week, multicentre, randomized, double‐blind, parallel‐group, active‐controlled, phase III clinical trial with a 28‐week extension
    S.‐M. Jin, C.‐Y. Park, Y. M. Cho, B. J. Ku, C. W. Ahn, B.‐S. Cha, K. W. Min, Y. A. Sung, S. H. Baik, K. W. Lee, K.‐H. Yoon, M.‐K. Lee, S. W. Park
    Diabetes, Obesity and Metabolism.2015; 17(6): 599.     CrossRef
  • Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection
    Travis S. Hughes, Henry D. Wilson, Ian Mitchelle S. de Vera, Douglas J. Kojetin, Paul C. Driscoll
    PLOS ONE.2015; 10(8): e0134474.     CrossRef
  • PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
    Flora Aparecida Milton, Aleksandra Cvoro, Angelica A. Amato, Douglas H. Sieglaff, Carly S. Filgueira, Anithachristy Sigamani Arumanayagam, Maria do Carmo Alves de Lima, Ivan Rocha Pitta, Francisco de Assis Rocha Neves, Paul Webb
    Biochemical and Biophysical Research Communications.2015; 464(3): 718.     CrossRef
  • Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity
    Wei-Xin Liu, Ting Wang, Feng Zhou, Ying Wang, Jun-Wei Xing, Shen Zhang, Shou-Zhi Gu, Li-Xuan Sang, Cong Dai, Hai-Lan Wang
    Biochemical and Biophysical Research Communications.2015; 459(3): 475.     CrossRef
  • Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
    Soo Lim, Kuy-Sook Lee, Jie Eun Lee, Ho Seon Park, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Young Bum Kim, Hak Chul Jang
    Atherosclerosis.2015; 243(1): 107.     CrossRef
  • Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
    A.J. Scheen, N. Esser, N. Paquot
    Diabetes & Metabolism.2015; 41(3): 183.     CrossRef
  • Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein
    Yanxiao Zhang, Jingcheng Yu, Chee Lee, Bin Xu, Maureen A. Sartor, Ronald J. Koenig
    Oncotarget.2015; 6(38): 40418.     CrossRef
  • Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
    Santiago Garcia-Vallvé, Laura Guasch, Sarah Tomas-Hernández, Josep Maria del Bas, Vincent Ollendorff, Lluís Arola, Gerard Pujadas, Miquel Mulero
    Journal of Medicinal Chemistry.2015; 58(14): 5381.     CrossRef
  • Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts
    Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim
    Genomics & Informatics.2014; 12(4): 195.     CrossRef
  • Pax-8–PPAR-γ fusion protein in thyroid carcinoma
    Priyadarshini Raman, Ronald J. Koenig
    Nature Reviews Endocrinology.2014; 10(10): 616.     CrossRef
  • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis
    Shinan Yin, Hua Bai, Danqing Jing
    Diagnostic Pathology.2014;[Epub]     CrossRef
  • Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation
    Ajaykumar N. Sharma, Isabelle E. Bauer, Marsal Sanches, Juan F. Galvez, Giovana B. Zunta-Soares, Joao Quevedo, Flavio Kapczinski, Jair C. Soares
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 54: 289.     CrossRef
Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
Dumitru Constantin-Teodosiu
Diabetes Metab J. 2013;37(5):301-314.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.301
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AbstractAbstract PDFPubReader   

Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset of type 2 diabetes (T2D). There are also situations where muscle insulin resistance can occur independently from high-fat dietary intake such as sepsis, inflammation, or drug administration though they all may share the same underlying mechanism, i.e., via activation of forkhead box family of transcription factors, and to a lower extent via peroxisome proliferator-activated receptors. The main feature of T2D is a chronic elevation in blood glucose levels. Chronic systemic hyperglycaemia is toxic and can lead to cellular dysfunction that may become irreversible over time due to deterioration of the pericyte cell's ability to provide vascular stability and control to endothelial proliferation. Therefore, it may not be surprising that T2D's complications are mainly macrovascular and microvascular related, i.e., neuropathy, retinopathy, nephropathy, coronary artery, and peripheral vascular diseases. However, life style intervention such as exercise, which is the most potent physiological activator of muscle PDC, along with pharmacological intervention such as administration of dichloroacetate or L-carnitine can prove to be viable strategies for treating muscle insulin resistance in obesity and T2D as they can potentially restore whole body glucose disposal.

Citations

Citations to this article as recorded by  
  • Oxidative stress and metabolism meet epigenetic modulation in physical exercise
    José Luis García-Giménez, Irene Cánovas-Cervera, Federico V. Pallardó
    Free Radical Biology and Medicine.2024; 213: 123.     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger
    Nick Schoenmann, Nicholas Tannenbaum, Ryan M. Hodgeman, Raghavan Pillai Raju
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(7): 166769.     CrossRef
  • Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
    Héctor F. Escobar-Morreale, María Ángeles Martínez-García, María Insenser, Nicolau Cañellas, Xavier Correig, Manuel Luque-Ramírez
    Biology of Sex Differences.2023;[Epub]     CrossRef
  • Metabolomics and mitochondrial dysfunction in cardiometabolic disease
    Abhishek Shastry, Kimberly Dunham-Snary
    Life Sciences.2023; 333: 122137.     CrossRef
  • Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
    Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
    Journal of Diabetes Investigation.2021; 12(1): 21.     CrossRef
  • Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
    Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568.     CrossRef
  • Effect of exercise training on skeletal muscle protein expression in relation to insulin sensitivity: Per‐protocol analysis of a randomized controlled trial (GO‐ACTIWE)
    Lea Bruhn, Rasmus Kjøbsted, Jonas Salling Quist, Anne Sofie Gram, Mads Rosenkilde, Kristine Færch, Jørgen F.P. Wojtaszewski, Bente Stallknecht, Martin Bæk Blond
    Physiological Reports.2021;[Epub]     CrossRef
  • The Mechanism behind Influenza Virus Cytokine Storm
    Yinuo Gu, Xu Zuo, Siyu Zhang, Zhuoer Ouyang, Shengyu Jiang, Fang Wang, Guoqiang Wang
    Viruses.2021; 13(7): 1362.     CrossRef
  • Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
    Nives Škorja Milić, Klemen Dolinar, Katarina Miš, Urška Matkovič, Maruša Bizjak, Mojca Pavlin, Matej Podbregar, Sergej Pirkmajer
    International Journal of Molecular Sciences.2021; 22(16): 8610.     CrossRef
  • The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis
    Hannah Crossland, Dumitru Constantin-Teodosiu, Paul L. Greenhaff
    International Journal of Molecular Sciences.2021; 22(18): 9775.     CrossRef
  • PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
    Hung-Che Chien, Despina Constantin, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
    Biology.2021; 10(11): 1098.     CrossRef
  • Molecular Mechanisms of Muscle Fatigue
    Dumitru Constantin-Teodosiu, Despina Constantin
    International Journal of Molecular Sciences.2021; 22(21): 11587.     CrossRef
  • Coronavirus Disease-19 (COVID-19) and Modern Lifestyle Diseases
    Pallav Sengupta, Sulagna Dutta
    Biomedical and Pharmacology Journal.2021; 14(4): 2245.     CrossRef
  • A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes
    Adam J. Bittel, Daniel C. Bittel, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Jun Yoshino, Lane C. Porter, Nada A. Abumrad, Dominic N. Reeds, W. Todd Cade
    Diabetologia.2020; 63(3): 611.     CrossRef
  • An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
    Jose A.L. Calbet, Saúl Martín-Rodríguez, Marcos Martin-Rincon, David Morales-Alamo
    Redox Biology.2020; 35: 101478.     CrossRef
  • PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation
    Hung-Che Chien, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
    International Journal of Molecular Sciences.2020; 21(16): 5942.     CrossRef
  • Cancer cachexia has many symptoms but only one cause: anoxia
    Tomas Koltai
    F1000Research.2020; 9: 250.     CrossRef
  • Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds
    Jihoon Kang, Haushabhau S. Pagire, Donguk Kang, Yo Han Song, In Kyu Lee, Kang Taek Lee, Chin-Ju Park, Jin Hee Ahn, Jungwook Kim
    Biochemical and Biophysical Research Communications.2020; 527(3): 778.     CrossRef
  • Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
    Livio Luzi, Maria Grazia Radaelli
    Acta Diabetologica.2020; 57(6): 759.     CrossRef
  • Changes in gene expression of lactate carriers (MCT1 and CD147) in cardiac muscle of diabetic male rats: the effect of dichloroacetate and endurance training
    H. Rezaeinasab, A. Habibi, M. Nikbakht, M. Rashno, S. Shakerian
    The Ukrainian Biochemical Journal.2020; 92(5): 111.     CrossRef
  • Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
    Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li
    Diabetes.2019; 68(12): 2197.     CrossRef
  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice
    Takuya Ohba, Shinichi Domoto, Miyu Tanaka, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
    Biological and Pharmaceutical Bulletin.2019; 42(7): 1140.     CrossRef
  • The Beta Cell in Type 2 Diabetes
    Ashley A. Christensen, Maureen Gannon
    Current Diabetes Reports.2019;[Epub]     CrossRef
  • Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
    Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
    Scientific Reports.2018;[Epub]     CrossRef
  • PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
    Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
    Diabetes.2018; 67(10): 2054.     CrossRef
  • Differences in Muscle Metabolism Between Triathletes and Normally Active Volunteers Investigated Using Multinuclear Magnetic Resonance Spectroscopy at 7T
    Radka Klepochová, Ladislav Valkovič, Thomas Hochwartner, Christoph Triska, Norbert Bachl, Harald Tschan, Siegfried Trattnig, Michael Krebs, Martin Krššák
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action
    Kristoffer Svensson, Jessica R. Dent, Shahriar Tahvilian, Vitor F. Martins, Abha Sathe, Julien Ochala, Mulchand S. Patel, Simon Schenk
    American Journal of Physiology-Endocrinology and Metabolism.2018; 315(5): E1034.     CrossRef
  • Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
    María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O’Hanlon, Antonio Gomez, Laura R. de la Ballina, Manel Esteller, Manuel Palacin, Donal J. O’Gorman, Joh
    Scientific Reports.2017;[Epub]     CrossRef
  • Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
    Peter W Stacpoole
    JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
  • Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4
    Luis V. Portela, Andressa W. Brochier, Clarissa B. Haas, Afonso Kopczynski de Carvalho, Jussania A. Gnoato, Eduardo R. Zimmer, Eduardo Kalinine, Luc Pellerin, Alexandre P. Muller
    Molecular Neurobiology.2017; 54(8): 5807.     CrossRef
  • Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock
    Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
    Scientific Reports.2017;[Epub]     CrossRef
  • The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate‐intensity exercise in human skeletal muscle
    A. Vigelsø, M. Gram, R. Dybboe, A. B. Kuhlman, C. Prats, P. L. Greenhaff, D. Constantin‐Teodosiu, J. B. Birk, J. F. P. Wojtaszewski, F. Dela, J. W. Helge
    The Journal of Physiology.2016; 594(8): 2339.     CrossRef
  • Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum
    Michael A. Moxley, Daniel A. Beard, Jason N. Bazil
    Journal of Biological Chemistry.2016; 291(6): 2712.     CrossRef
  • Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
    Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
    Scientific Reports.2016;[Epub]     CrossRef
  • Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A
    S.A. Ljunggren, M. Iggland, M. Rönn, L. Lind, P.M. Lind, H. Karlsson
    Toxicology.2016; 347-349: 6.     CrossRef
  • Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
    Bjorn T. Tam, Xiao M. Pei, Benjamin Y. Yung, Shea P. Yip, Lawrence W. Chan, Cesar S. Wong, Parco M. Siu
    Pflügers Archiv - European Journal of Physiology.2015; 467(12): 2555.     CrossRef
  • Sex-related differences in the effects of high-fat diets on DHEA-treated rats
    Ana Lúcia Cecconello, Marcia Trapp, Ana Lúcia Hoefel, Cláudia Vieira Marques, Bruno Dutra Arbo, Gabriela Osterkamp, Luiz Carlos Rios Kucharski, Maria Flávia Marques Ribeiro
    Endocrine.2015; 48(3): 985.     CrossRef
  • Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
    Sergio Arrabal, Miguel Angel Lucena, Miren Josune Canduela, Almudena Ramos-Uriarte, Patricia Rivera, Antonia Serrano, Francisco Javier Pavón, Juan Decara, Antonio Vargas, Elena Baixeras, Mercedes Martín-Rufián, Javier Márquez, Pedro Fernández-Llébrez, Bau
    PLOS ONE.2015; 10(12): e0145244.     CrossRef
  • A glance at … exercise and glucose uptake
    Michael J. Glade, Kyl Smith
    Nutrition.2015; 31(6): 893.     CrossRef
  • Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding–induced muscle insulin resistance
    Dumitru Constantin-Teodosiu, Francis B. Stephens, Paul L. Greenhaff
    Proceedings of the National Academy of Sciences.2015;[Epub]     CrossRef
  • Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content
    Craig A. Goodman, Derk Pol, Evelyn Zacharewicz, Robert S. Lee-Young, Rod J. Snow, Aaron P. Russell, Glenn K. McConell, Ashok Kumar
    PLOS ONE.2015; 10(5): e0128398.     CrossRef
  • 13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
    Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
    BMC Systems Biology.2014;[Epub]     CrossRef
  • Translational Research: From Biological Discovery to Public Benefit (or Not)
    Michael R. Emmert-Buck
    Advances in Biology.2014; 2014: 1.     CrossRef
  • Diabetic Worker with History of Falls: A Case Study
    Ann R. Lurati
    Workplace Health & Safety.2014; 62(5): 175.     CrossRef
  • Diabetic Worker With History of Falls: A Case Study
    Ann R. Lurati
    Workplace Health & Safety.2014; 62(5): 175.     CrossRef
  • Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
    Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
    Cell Reports.2014; 7(6): 2042.     CrossRef
Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee
Diabetes Metab J. 2012;36(5):328-335.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.328
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AbstractAbstract PDFPubReader   

The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it has been reported that PDC is phosphorylated and inactivated by PDK2 and PDK4 in metabolically active tissues including liver, skeletal muscle, heart, and kidney during starvation and diabetes, the precise mechanisms by which expression of PDK2 and PDK4 are transcriptionally regulated still remains unclear. Insulin represses the expression of PDK2 and PDK4 via phosphorylation of FOXO through PI3K/Akt signaling pathway. Several nuclear hormone receptors activated due to fasting or increased fat supply, including peroxisome proliferator-activated receptors, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors, also participate in the up-regulation of PDK2 and PDK4; however, the endogenous ligands that bind those nuclear receptors have not been identified. It has been recently suggested that growth hormone, adiponectin, epinephrine, and rosiglitazone also control the expression of PDK4 in tissue-specific manners. In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.

Citations

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  • Molecules and targets of antidiabetic interest
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    Phytomedicine Plus.2024; 4(1): 100506.     CrossRef
  • Transcriptome analysis reveals dysfunction of the endoplasmic reticulum protein processing in the sonic muscle of small yellow croaker (Larimichthys polyactis) following noise exposure
    Xuguang Zhang, Xianming Tang, Jianan Xu, Yueping Zheng, Jun Lin, Huafeng Zou
    Marine Environmental Research.2024; 194: 106299.     CrossRef
  • Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation
    Jinyong Chen, Tanchen Ren, Lan Xie, Haochang Hu, Xu Li, Miribani Maitusong, Xuhao Zhou, Wangxing Hu, Dilin Xu, Yi Qian, Si Cheng, Kaixiang Yu, Jian`an Wang, Xianbao Liu
    Nature Communications.2024;[Epub]     CrossRef
  • Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
    Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha
    International Journal of Molecular Sciences.2024; 25(2): 807.     CrossRef
  • Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women
    Zhaleh Pashaei, Abbas Malandish, Shahriar Alipour, Afshar Jafari, Ismail Laher, Anthony C. Hackney, Katsuhiko Suzuki, Urs Granacher, Ayoub Saeidi, Hassane Zouhal
    BMC Sports Science, Medicine and Rehabilitation.2024;[Epub]     CrossRef
  • Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOS
    Ling Hong, Shan Xiao, Lianghui Diao, Ruochun Lian, Cong Chen, Yong Zeng, Su Liu
    Cellular and Molecular Life Sciences.2024;[Epub]     CrossRef
  • Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes
    Ayami Kita, Ryota Araki, Takeshi Yabe
    Biological and Pharmaceutical Bulletin.2024; 47(9): 1542.     CrossRef
  • 1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation
    Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju
    BMC Cancer.2023;[Epub]     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • A Conceptual Approach for Examining Effects of the Adolescent Bone Marrow Milieu on MSC Phenotype
    Sanjana Kannikeswaran, Daniel G Whitney, Maureen J Devlin, Ying Li, Michelle S Caird, Andrea I Alford
    JBMR Plus.2023;[Epub]     CrossRef
  • Targeting PDK2 rescues stress-induced impaired brain energy metabolism
    Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang
    Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
    Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah
    Kidney International.2023; 104(4): 724.     CrossRef
  • High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression
    Pengyu Wei, Dongxu Lin, Changcheng Luo, Mengyang Zhang, Bolang Deng, Kai Cui, Zhong Chen
    Scientific Reports.2023;[Epub]     CrossRef
  • PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression
    Zhouji Ma, Ran Mo, Ping Yang, Youjun Ding, Hao Zhang, Zheng Dong, Yutong Chen, Qian Tan
    The FASEB Journal.2023;[Epub]     CrossRef
  • PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
    Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan
    Cell Death Discovery.2023;[Epub]     CrossRef
  • CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function
    Huimin Niu, Xiayu Ren, Enxue Tan, Xing Wan, Yu Wang, Honghong Shi, Yanjuan Hou, Lihua Wang
    Renal Failure.2023;[Epub]     CrossRef
  • PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
    Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li
    Antioxidants & Redox Signaling.2022; 36(7-9): 505.     CrossRef
  • microRNA-15b-5p shuttled by mesenchymal stem cell-derived extracellular vesicles protects podocytes from diabetic nephropathy via downregulation of VEGF/PDK4 axis
    Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li
    Journal of Bioenergetics and Biomembranes.2022; 54(1): 17.     CrossRef
  • Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
    Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer’s Disease Consistent With Cerebral Pantothenate Deficiency
    Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Identification of candidate aberrant differentially methylated/expressed genes in asthma
    Zongling Wang, Lizhi Wang, Lina Dai, Yanan Wang, Erhong Li, Shuyuan An, Fengliang Wang, Dan Liu, Wen Pan
    Allergy, Asthma & Clinical Immunology.2022;[Epub]     CrossRef
  • Innervation and electrical pulse stimulation — in vitro effects on human skeletal muscle cells
    Tomaz Marš, Katarina Miš, Marija Meznarič, Sonja Prpar Mihevc, Vid Jan, Fred Haugen, Boris Rogelj, Arild C. Rustan, G. Hege Thoresen, Sergej Pirkmajer, Nataša Nikolić
    Applied Physiology, Nutrition, and Metabolism.2021; 46(4): 299.     CrossRef
  • Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?
    Kanchan Phadwal, Christina Vrahnas, Ian G. Ganley, Vicky E. MacRae
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
    Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
    Developmental Cell.2021; 56(8): 1182.     CrossRef
  • Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows
    Valentino Palombo, Abdulrahman Alharthi, Fernanda Batistel, Claudia Parys, Jessie Guyader, Erminio Trevisi, Mariasilvia D’Andrea, Juan J. Loor
    BMC Genomics.2021;[Epub]     CrossRef
  • PDK2: An Underappreciated Regulator of Liver Metabolism
    Benjamin L. Woolbright, Robert A. Harris
    Livers.2021; 1(2): 82.     CrossRef
  • Endocrine Influence on Cardiac Metabolism in Development and Regeneration
    Niall Graham, Guo N Huang
    Endocrinology.2021;[Epub]     CrossRef
  • Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas
    Kristina M. Cook, Han Shen, Kelly J. McKelvey, Harriet E. Gee, Eric Hau
    International Journal of Molecular Sciences.2021; 22(14): 7265.     CrossRef
  • Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20
    Duanfeng Jiang, Qiuyu Mo, Xiaoying Sun, Xiaotao Wang, Min Dong, Guozhen Zhang, Fangping Chen, Qiangqiang Zhao
    Cancer Science.2021; 112(9): 3585.     CrossRef
  • Skeletal muscle energy metabolism in obesity
    Abel M. Mengeste, Arild C. Rustan, Jenny Lund
    Obesity.2021; 29(10): 1582.     CrossRef
  • Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
    Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Je
    PLOS Pathogens.2021; 17(10): e1009991.     CrossRef
  • Transcriptional and free radical responses to LVAD therapy
    Kajari Dhar, Asmini KC, Fang Qiu, Hesham Basma, Krupa K. Savalia, Jocelyn Jones, Alexandra M. Moulton, Matthew C. Zimmerman, John Um, Daniel Anderson, Marshall Hyden, Brian D. Lowes
    Translational Medicine Communications.2020;[Epub]     CrossRef
  • Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
    Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
    Cancer & Metabolism.2020;[Epub]     CrossRef
  • Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply
    Emilio Mármol-Sánchez, Yuliaxis Ramayo-Caldas, Raquel Quintanilla, Tainã Figueiredo Cardoso, Rayner González-Prendes, Joan Tibau, Marcel Amills
    Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
  • Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
    Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall
    Journal of Leukocyte Biology.2020; 107(3): 467.     CrossRef
  • GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia
    Masahiro Hata, Hiroto Kinoshita, Yoku Hayakawa, Mitsuru Konishi, Mayo Tsuboi, Yukiko Oya, Ken Kurokawa, Yuki Hayata, Hayato Nakagawa, Keisuke Tateishi, Hiroaki Fujiwara, Yoshihiro Hirata, Daniel L. Worthley, Yuki Muranishi, Takahisa Furukawa, Shunsuke Kon
    Gastroenterology.2020; 158(6): 1650.     CrossRef
  • The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
    Tao Gao, Dan He, Xin Liu, Fang Ji, Jianhong Xu, Jianrong Shi
    Food Production, Processing and Nutrition.2020;[Epub]     CrossRef
  • PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis
    Ji-Min Lee, Min-Ji Kim, Sun Joo Lee, Byung-Gyu Kim, Je-Yong Choi, Seung Mi Lee, Hye Jin Ham, Jung-Min Koh, Jae-Han Jeon, In-Kyu Lee
    Journal of Bone and Mineral Research.2020; 36(3): 553.     CrossRef
  • Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
    Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha
    Scientific Reports.2020;[Epub]     CrossRef
  • Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
    Marlena Zyśk, Piotr Pikul, Robert Kowalski, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk
    International Journal of Molecular Sciences.2020; 21(22): 8541.     CrossRef
  • PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
    Wen-Qi Ma, Xue-Jiao Sun, Yi Zhu, Nai-Feng Liu
    Cell Death & Disease.2020;[Epub]     CrossRef
  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
    Yan Li, Haiou Pan, Xuetong Zhang, Hui Wang, Shengnan Liu, Hui Zhang, Haifeng Qian, Li Wang, Hao Ying
    Journal of Agricultural and Food Chemistry.2019; 67(16): 4483.     CrossRef
  • The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
    A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Beom Seok Kang, Dong Hyeon Kang, Kyoung-Ha Park, Jae Bong Park, Sang Won Suh
    Cells.2019; 8(5): 405.     CrossRef
  • Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
    Gyuri Kim, Myungeun Yoo, Min Hee Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hye Ryun Kim, Yong-ho Lee, Byoung Chul Cho
    Cancer Chemotherapy and Pharmacology.2019; 84(2): 405.     CrossRef
  • Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
    Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
    Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
  • PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
    Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee
    Diabetes.2019; 68(3): 571.     CrossRef
  • Membrane-initiated cortisol action modulates early pyruvate dehydrogenase kinase 2 (pdk2) expression in fish skeletal muscle
    Jorge E. Aedo, Rodrigo Zuloaga, Sebastián Boltaña, Alfredo Molina, Juan Antonio Valdés
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2019; 233: 24.     CrossRef
  • Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
    Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
    Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
  • Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
    Azuma Kosai, Nanao Horike, Yoshiaki Takei, Akihiro Yamashita, Kaori Fujita, Takashi Kamatani, Noriyuki Tsumaki
    Biochemical and Biophysical Research Communications.2019; 516(4): 1097.     CrossRef
  • Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
    Maria F. Newhardt, Albert Batushansky, Satoshi Matsuzaki, Zachary T. Young, Melinda West, Ngun Cer Chin, Luke I. Szweda, Michael Kinter, Kenneth M. Humphries
    Journal of Biological Chemistry.2019; 294(45): 16831.     CrossRef
  • Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
    Ina Katrine Nitschke Pettersen, Deusdedit Tusubira, Hanan Ashrafi, Sissel Elisabeth Dyrstad, Lena Hansen, Xiao-Zheng Liu, Linn Iren Hodneland Nilsson, Nils Gunnar Løvsletten, Kjetil Berge, Hege Wergedahl, Bodil Bjørndal, Øystein Fluge, Ove Bruland, Arild
    Mitochondrion.2019; 49: 97.     CrossRef
  • Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
    Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris, John A. Taylor
    Molecular Cancer Therapeutics.2019; 18(10): 1673.     CrossRef
  • Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
    Patricia G. Rosenstein, Brett S. Tennent‐Brown, Dez Hughes
    Journal of Veterinary Emergency and Critical Care.2018; 28(2): 85.     CrossRef
  • SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
    Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S. Atreya, Ullas Kolthur‐Seetharam, Nagalingam R. Sundaresan
    Journal of Cellular Physiology.2018; 233(7): 5478.     CrossRef
  • Metabolic Changes Associated With Muscle Expression of SOD1G93A
    Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musarò
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue
    Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López, María del Mar Romero, Marià Alemany
    PeerJ.2018; 6: e5440.     CrossRef
  • Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
    Lidan Zhao, Ryan P. McMillan, Guohao Xie, Samantha G. L. W. Giridhar, Lance H. Baumgard, Samer El-Kadi, Joshua Selsby, Jason Ross, Nicholas Gabler, Matthew W. Hulver, Robert P. Rhoads
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1096.     CrossRef
  • Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
    Rong Ke, Qicao Xu, Cong Li, Lingyu Luo, Deqiang Huang
    Cell Biology International.2018; 42(4): 384.     CrossRef
  • Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism
    Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu
    Scientific Reports.2018;[Epub]     CrossRef
  • Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
    Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
    Oncotarget.2017; 8(68): 112841.     CrossRef
  • Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
    Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
    Kidney International.2017; 91(4): 880.     CrossRef
  • PPARβ/δ in human cancer
    Rolf Müller
    Biochimie.2017; 136: 90.     CrossRef
  • The physiological and molecular response of Aurelia sp.1 under hypoxia
    Guoshan Wang, Yu Zhen, Zhigang Yu, Yan Shi, Qing Zhao, Jianyan Wang, Tiezhu Mi
    Scientific Reports.2017;[Epub]     CrossRef
  • A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration
    Víctor López del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 801.     CrossRef
  • Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
    Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
    The Journal of Nutritional Biochemistry.2017; 39: 126.     CrossRef
  • Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
    Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier
    PLOS ONE.2017; 12(10): e0186021.     CrossRef
  • Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy
    Sahoko Ichihara, Yuka Suzuki, Jie Chang, Kentaro Kuzuya, Chisa Inoue, Yuki Kitamura, Shinji Oikawa
    Scientific Reports.2017;[Epub]     CrossRef
  • Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
    Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli, Sylvie Bortoli
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Oncogenic role of PDK4 in human colon cancer cells
    D Leclerc, D N T Pham, N Lévesque, M Truongcao, W D Foulkes, C Sapienza, R Rozen
    British Journal of Cancer.2017; 116(7): 930.     CrossRef
  • Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
    Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama
    The Journal of Poultry Science.2017; 54(4): 292.     CrossRef
  • Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
    Peter W Stacpoole
    JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
  • Reference Gene Selection and Prednisolone Target Gene Expression in Adipose Tissues of Friesian Cattle
    Sara Divari, Enrica Berio, Bartolomeo Biolatti, Francesca Tiziana Cannizzo
    Journal of Agricultural and Food Chemistry.2017; 65(50): 11140.     CrossRef
  • Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
    Luana Naia, Teresa Cunha-Oliveira, Joana Rodrigues, Tatiana R. Rosenstock, Ana Oliveira, Márcio Ribeiro, Catarina Carmo, Sofia I. Oliveira-Sousa, Ana I. Duarte, Michael R. Hayden, A. Cristina Rego
    The Journal of Neuroscience.2017; 37(10): 2776.     CrossRef
  • Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
    Mina Kim, Dae Keun Kim, Youn-Soo Cha
    Journal of Medicinal Food.2016; 19(5): 442.     CrossRef
  • Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
    Hana Park, Nam Ho Jeoung
    Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
  • Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
    Jaechan Leem, In-Kyu Lee
    Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
  • Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
    Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress
    Frontiers in Physiology.2016;[Epub]     CrossRef
  • MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
    Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
    PLOS Genetics.2016; 12(10): e1006308.     CrossRef
  • Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
    Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, Jing Wang
    Journal of Biological Chemistry.2016; 291(33): 17405.     CrossRef
  • Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk
    Franziska Koch, Ole Lamp, Mehdi Eslamizad, Joachim Weitzel, Björn Kuhla, Andrew C. Gill
    PLOS ONE.2016; 11(8): e0160912.     CrossRef
  • Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver
    Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland, Brenda K. Richards
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
    Mithilesh Kumar Jha, In-Kyu Lee, Kyoungho Suk
    Neuroscience & Biobehavioral Reviews.2016; 68: 1.     CrossRef
  • 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
    Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar
    Journal of Biological Chemistry.2016; 291(3): 1514.     CrossRef
  • Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
    Sina Oppermann, Avery J. Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, Guizhei Wang, Jarkko Ylanko, Brian Leber, David Andrews, David E. Spaner
    Oncotarget.2016; 7(45): 72608.     CrossRef
  • Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments
    Hiroshi Kido, Irene L. Indalao, Hyejin Kim, Takashi Kimoto, Satoko Sakai, Etsuhisa Takahashi
    Respiratory Investigation.2016; 54(5): 312.     CrossRef
  • Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity
    Tao Gao, Jian Chen, Zhiqi Shi, Yin-Won Lee
    PLOS ONE.2016; 11(6): e0158077.     CrossRef
  • Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
    Michael J. Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F. Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E. Scott, Lubos Bohunek, Jerzy E. Kulpa, S. R. Wayne Chen, David Fedida, Roger W. Brownsey, Christoph H. Borchers, Leonard J. Fo
    Journal of Biological Chemistry.2016; 291(45): 23490.     CrossRef
  • Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
    Nam Ho Jeoung
    Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
  • Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells
    Mariana Regueira, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, María Fernanda Riera
    REPRODUCTION.2015; 150(4): 311.     CrossRef
  • Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes
    Anna Polus, Beata Kiec-Wilk, Urszula Razny, Anna Gielicz, Gerd Schmitz, Aldona Dembinska-Kiec
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2015; 1851(9): 1146.     CrossRef
  • A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
    Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René
    EMBO Molecular Medicine.2015; 7(5): 526.     CrossRef
  • A genetic perspective on rapid evolution in cane toads (Rhinella marina)
    Lee A. Rollins, Mark F. Richardson, Richard Shine
    Molecular Ecology.2015; 24(9): 2264.     CrossRef
  • Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
    Qin Hao, Rachita Yadav, Astrid L. Basse, Sidsel Petersen, Si B. Sonne, Simon Rasmussen, Qianhua Zhu, Zhike Lu, Jun Wang, Karine Audouze, Ramneek Gupta, Lise Madsen, Karsten Kristiansen, Jacob B. Hansen
    American Journal of Physiology-Endocrinology and Metabolism.2015; 308(5): E380.     CrossRef
  • Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
    Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myeong Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A
    Scientific Reports.2015;[Epub]     CrossRef
  • Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
    Laura D. Brown, Paul J. Rozance, Jennifer L. Bruce, Jacob E. Friedman, William W. Hay, Stephanie R. Wesolowski
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R920.     CrossRef
  • The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
    T Joshi, M Johnson, R Newton, M A Giembycz
    British Journal of Pharmacology.2015; 172(10): 2634.     CrossRef
  • The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
    Jianrong Lu, Ming Tan, Qingsong Cai
    Cancer Letters.2015; 356(2): 156.     CrossRef
  • The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
    In-Kyu Lee
    Diabetes & Metabolism Journal.2014; 38(3): 181.     CrossRef
  • Rapid in Vitro Metabolism of the Flame Retardant Triphenyl Phosphate and Effects on Cytotoxicity and mRNA Expression in Chicken Embryonic Hepatocytes
    Guanyong Su, Doug Crump, Robert J. Letcher, Sean W. Kennedy
    Environmental Science & Technology.2014; 48(22): 13511.     CrossRef
  • Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury
    Michael A. Petrie, Manish Suneja, Elizabeth Faidley, Richard K. Shields
    Physiological Reports.2014; 2(2): e00248.     CrossRef
  • Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
    Kazuhiko Yamane, Irene L. Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido, Amy Lynn Adamson
    PLoS ONE.2014; 9(5): e98032.     CrossRef
  • Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal
    Maria Guitart, Óscar Osorio-Conles, Thais Pentinat, Judith Cebrià, Judit García-Villoria, David Sala, David Sebastián, Antonio Zorzano, Antonia Ribes, Josep C. Jiménez-Chillarón, Celia García-Martínez, Anna M. Gómez-Foix, Cedric Moro
    PLoS ONE.2014; 9(5): e98109.     CrossRef
  • CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
    Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2014; 1843(2): 372.     CrossRef
  • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
    Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, Anne C. Ferguson-Smith
    Proceedings of the National Academy of Sciences.2014; 111(45): 16088.     CrossRef
  • The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
    Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
    Nutrition & Metabolism.2014;[Epub]     CrossRef
  • Time-dependent effects of the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds
    Amani Farhat, Doug Crump, Emily Porter, Suzanne Chiu, Robert J. Letcher, Guanyong Su, Sean W. Kennedy
    Environmental Toxicology and Chemistry.2014; 33(12): 2842.     CrossRef
  • Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue
    S Zhang, R P McMillan, M W Hulver, P B Siegel, L H Sumners, W Zhang, M A Cline, E R Gilbert
    International Journal of Obesity.2014; 38(10): 1374.     CrossRef
  • Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
    Yolanda F. Otero, John M. Stafford, Owen P. McGuinness
    Journal of Biological Chemistry.2014; 289(30): 20462.     CrossRef
  • Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells
    Eili Tranheim Kase, Nataša Nikolić, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan, Darcy Johannsen
    PLoS ONE.2013; 8(4): e59972.     CrossRef
  • Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
    Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian
    Diabetes & Metabolism Journal.2013; 37(4): 270.     CrossRef
  • The orphan nuclear receptors in cancer and diabetes
    Harmit S. Ranhotra
    Journal of Receptors and Signal Transduction.2013; 33(4): 207.     CrossRef
  • Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
    Daniel Leclerc, Nancy Lévesque, Yuanhang Cao, Liyuan Deng, Qing Wu, Jasmine Powell, Carmen Sapienza, Rima Rozen
    Cancer Prevention Research.2013; 6(11): 1171.     CrossRef
Original Article
Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park
Diabetes Metab J. 2011;35(4):340-347.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.340
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AbstractAbstract PDFPubReader   
Background

Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ), one of the nuclear receptors. In this study, we investigated the effects of sulfonylurea on PPARγ transcriptional activity and on the glucose uptake via PPARγ.

Methods

Transcription reporter assays using Cos7 cells were performed to determine if specific sulfonylureas stimulate PPARγ transactivation. Glimepiride, gliquidone, and glipizide (1 to 500 µM) were used as treatment, and rosiglitazone at 1 and 10 µM was used as a control. The effects of sulfonylurea and rosiglitazone treatments on the transcriptional activity of endogenous PPARγ were observed. In addition, 3T3-L1 adipocytes were treated with rosiglitazone (10 µM), glimepiride (100 µM) or both to verify the effect of glimepiride on rosiglitazone-induced glucose uptake.

Results

Sulfonylureas, including glimepiride, gliquidone and glipizide, increased PPARγ transcriptional activity, gliquidone being the most potent PPARγ agonist. However, no additive effects were observed in the presence of rosiglitazone. When rosiglitazone was co-treated with glimepiride, PPARγ transcriptional activity and glucose uptake were reduced compared to those after treatment with rosiglitazone alone. This competitive effect of glimepiride was observed only at high concentrations that are not achieved with clinical doses.

Conclusion

Sulfonylureas like glimepiride, gliquidone and glipizide increased the transcriptional activity of PPARγ. Also, glimepiride was able to reduce the effect of rosiglitazone on PPARγ agonistic activity and glucose uptake. However, the competitive effect does not seem to occur at clinically feasible concentrations.

Citations

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  • Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation
    Bodo Haas, Moritz David Sebastian Hass, Alexander Voltz, Matthias Vogel, Julia Walther, Arijit Biswas, Daniela Hass, Alexander Pfeifer
    Molecular Metabolism.2024; 85: 101956.     CrossRef
  • Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats
    Omayma A. R. Abozaid, Sawsan M. El-Sonbaty, Neama M. A. Hamam, Moustafa A. Farrag, Ahmad S. Kodous
    Biological Trace Element Research.2023; 201(1): 306.     CrossRef
  • Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus
    Ayesha Fauzi, Ewen Se Thoe, Tang Yin Quan, Adeline Chia Yoke Yin
    Journal of Diabetes and its Complications.2023; 37(11): 108629.     CrossRef
  • Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes
    Mika E. A. Berg, Jette-Britt Naams, Laura C. Hautala, Tuomas A. Tolvanen, Jari P. Ahonen, Sanna Lehtonen, Kristiina Wähälä
    ACS Omega.2020; 5(3): 1430.     CrossRef
  • Diabetic Theory in Anti-Alzheimer’s Drug Research and Development - Part 1: Therapeutic Potential of Antidiabetic Agents
    Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa
    Current Medicinal Chemistry.2020; 27(39): 6658.     CrossRef
  • Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats
    Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Vijayakumar Mayakrishnan, Arokiyaraj Selvaraj
    Biomedicine & Pharmacotherapy.2019; 112: 108688.     CrossRef
  • PPARγ Agonistic Activity of Sulphonylureas
    Debjani Banerjee, Harnovdeep Singh Bharaj, Moulinath Banerjee
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(4): 467.     CrossRef
  • Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene
    Zhimin Huang, Juan Liu, Kaka Ng, Xuesi Wan, Lijuan Xu, Xiaoying He, Zhihong Liao, Yanbing Li
    Journal of Diabetes Investigation.2018; 9(5): 1075.     CrossRef
  • Arsenic, Cadmium, and Lead Like Troglitazone Trigger PPARγ-Dependent Poly (ADP-Ribose) Polymerase Expression and Subsequent Apoptosis in Rat Brain Astrocytes
    Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Puneet Khare, Sanghamitra Bandyopadhyay
    Molecular Neurobiology.2018; 55(3): 2125.     CrossRef
  • Docosahexaenoic acid up‐regulates both PI3K/AKT‐dependent FABP7–PPARγ interaction and MKP3 that enhance GFAP in developing rat brain astrocytes
    Sachin Tripathi, Rajesh Kushwaha, Juhi Mishra, Manoj Kumar Gupta, Harish Kumar, Somali Sanyal, Dhirendra Singh, Sabyasachi Sanyal, Amogh Anant Sahasrabuddhe, Mohan Kamthan, Mohana Krishna Reddy Mudiam, Sanghamitra Bandyopadhyay
    Journal of Neurochemistry.2017; 140(1): 96.     CrossRef
  • Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes
    Krishna Adeshara, Rashmi Tupe
    Molecular Biology Reports.2016; 43(3): 195.     CrossRef
  • The therapeutic journey of pyridazinone
    Wasim Akhtar, M. Shaquiquzzaman, Mymoona Akhter, Garima Verma, Mohemmed Faraz Khan, M. Mumtaz Alam
    European Journal of Medicinal Chemistry.2016; 123: 256.     CrossRef
  • Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect
    Chetna Kharbanda, Mohammad Sarwar Alam, Hinna Hamid, Kalim Javed, Abhijeet Dhulap, Sameena Bano, Yakub Ali
    Bioorganic & Medicinal Chemistry Letters.2015; 25(20): 4601.     CrossRef
  • Method Development and Validation of Amlodipine, Gliquidone and Pioglitazone: Application in the Analysis of Human Serum
    Agha Zeeshan Mirza, M. Saeed Arayne, Najma Sultana
    Analytical Chemistry Letters.2014; 4(5-6): 302.     CrossRef
  • Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats
    Jian-Ting Ke, Mi Li, Shi-Qing Xu, Wen-Jian Zhang, Yong-Wei Jiang, Lan-yun Cheng, Li Chen, Jin-Ning Lou, Wei Wu
    Journal of Endocrinology.2014; 220(2): 129.     CrossRef
  • Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico
    Samuel E. Schriner, Steven Kuramada, Terry E. Lopez, Stephanie Truong, Andrew Pham, Mahtab Jafari
    Experimental Gerontology.2014; 60: 220.     CrossRef
  • Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice
    Min Jeong Ryu, Soung Jung Kim, Yong Kyung Kim, Min Jeong Choi, Surendar Tadi, Min Hee Lee, Seong Eun Lee, Hyo Kyun Chung, Saet Byel Jung, Hyun-Jin Kim, Young Suk Jo, Koon Soon Kim, Sang-Hee Lee, Jin Man Kim, Gi Ryang Kweon, Ki Cheol Park, Jung Uee Lee, Yo
    PLoS Genetics.2013; 9(3): e1003356.     CrossRef
  • Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons
    Feiyang Liu, Yijin Wang, Ming Yan, Luyong Zhang, Tao Pang, Hong Liao
    Neuroscience Letters.2013; 557: 90.     CrossRef
  • Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis
    A. Cignarelli, F. Giorgino, R. Vettor
    Archives of Physiology and Biochemistry.2013; 119(4): 139.     CrossRef
  • Labisia pumilaUpregulates Peroxisome Proliferator-Activated Receptor Gamma Expression in Rat Adipose Tissues and 3T3-L1 Adipocytes
    Fazliana Mansor, Harvest F. Gu, Claes-Göran Östenson, Louise Mannerås-Holm, Elisabet Stener-Victorin, Wan Nazaimoon Wan Mohamud
    Advances in Pharmacological Sciences.2013; 2013: 1.     CrossRef
  • Protocol for effective differentiation of 3T3-L1 cells to adipocytes
    Katja Zebisch, Valerie Voigt, Martin Wabitsch, Matthias Brandsch
    Analytical Biochemistry.2012; 425(1): 88.     CrossRef
Review
Functional and Mechanistic Integration of Infection and the Metabolic Syndrome
Peter Sommer, Gary Sweeney
Korean Diabetes J. 2010;34(2):71-76.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.71
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AbstractAbstract PDFPubReader   

The metabolic syndrome refers to a well defined group of risk factors, including central obesity and inflammation, for the development of diabetes and cardiovascular disease. Interestingly, many studies have recently led to the emergence of somewhat unexpected relationships between several infectious diseases and various aspects of the metabolic syndrome. Our understanding of the mechanisms underlying these interactions is also rapidly developing and some of these are summarized in this article. We will focus first on bacterial infection, and most notably the role of gut microbiota in regulaton of both obesity and inflammation. In particular, we focus on the role of inflammasomes and propose that understanding the role of Toll-like receptors and Nod-like receptors in the pathogenesis of inflammatory disorders with or without infection may provide novel targets for prevention and/or treatment of associated diseases. Secondly, chronic bacterial or viral infection and emerging links with metabolism will be reviewed. Finally, consideratons of biomarkers for metabolic syndrome, in particular lipocalin-2, and their link with infection will be discussed.

Citations

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  • The immunology of sickness metabolism
    Felix M. Wensveen, Marko Šestan, Bojan Polić
    Cellular & Molecular Immunology.2024; 21(9): 1051.     CrossRef
  • The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome
    Timea Claudia Ghitea, Amina El-Kharoubi, Mariana Ganea, Erika Bimbo-Szuhai, Tiberiu Sebastian Nemeth, Gabriela Ciavoi, Monica Foghis, Luciana Dobjanschi, Annamaria Pallag, Otilia Micle
    Molecules.2021; 26(2): 283.     CrossRef
  • COVID-19 severity in relation to sociodemographics and vitamin D use
    Darya Saeed Abdulateef, Heshu Sulaiman Rahman, Jamal Mahmood Salih, Sangar Mahmoud Osman, Trifa Abdalla Mahmood, Shirwan Hama Salih Omer, Rana Adnan Ahmed
    Open Medicine.2021; 16(1): 591.     CrossRef
  • Iron Reshapes the Gut Microbiome and Host Metabolism
    Amy Botta, Nicole G. Barra, Nhat Hung Lam, Samantha Chow, Kostas Pantopoulos, Jonathan D. Schertzer, Gary Sweeney
    Journal of Lipid and Atherosclerosis.2021; 10(2): 160.     CrossRef
  • Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection
    Anil Pant, Lara Dsouza, Zhilong Yang, Benjamin Gewurz, Vinayaka R. Prasad
    mBio.2021;[Epub]     CrossRef
  • Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome
    Altansuvd Enkhtur, Joon-Sup Yoon, Chang-Woo Lee
    Precision and Future Medicine.2020; 4(3): 83.     CrossRef
  • Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes
    Erfei Song, Sofhia V. Ramos, Xiaojing Huang, Ying Liu, Amy Botta, Hye Kyoung Sung, Patrick C. Turnbull, Michael B. Wheeler, Thorsten Berger, Derek J. Wilson, Christopher G. R. Perry, Tak W. Mak, Gary Sweeney
    Proceedings of the National Academy of Sciences.2018; 115(7): 1576.     CrossRef
  • Tuberculosis of the Breast: An Initial Presentation of the Metabolic Syndrome with Type 2 Diabetes Mellitus in a Young Nigerian Woman
    M. A. Adeiza, R. Yusuf, A. A. Liman, P. Abur, F. Bello, A. A. Abba
    Case Reports in Infectious Diseases.2016; 2016: 1.     CrossRef
  • Systematic Review of the Relation Between Intestinal Microbiota and Toll-Like Receptors in the Metabolic Syndrome: What Do We Know So Far?
    José Pedro Portela-Cidade, Marta Borges-Canha, Adelino Ferreira Leite-Moreira, Pedro Pimentel-Nunes
    GE Portuguese Journal of Gastroenterology.2015; 22(6): 240.     CrossRef
  • Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
    Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
    International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
  • Regulation of Iron and Its Significance in Obesity and Complications
    Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney
    The Korean Journal of Obesity.2014; 23(4): 222.     CrossRef
  • Direct effects of adipokines on the heart: focus on adiponectin
    Min Park, Gary Sweeney
    Heart Failure Reviews.2013; 18(5): 631.     CrossRef
  • The Thioredoxin System as a Therapeutic Target in Human Health and Disease
    Dler Faieeq Darweesh Mahmood, Amna Abderrazak, Khadija El Hadri, Thomas Simmet, Mustapha Rouis
    Antioxidants & Redox Signaling.2013; 19(11): 1266.     CrossRef
  • Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Wei Qiu, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi
    Annals of Medicine.2013; 45(3): 220.     CrossRef
  • Immunoglobulin E and Mast Cell Proteases Are Potential Risk Factors of Human Pre-Diabetes and Diabetes Mellitus
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi, Yiqing Song
    PLoS ONE.2011; 6(12): e28962.     CrossRef

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