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Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
Diabetes Metab J. 2024;48(3):405-417.   Published online February 1, 2024
DOI: https://doi.org/10.4093/dmj.2023.0196
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury. The present study investigated the role of pyruvate dehydrogenase kinase 4 (PDK4) in ROS production and inflammation following IR injury.
Methods
We used a streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected to IR by clamping both renal pedicles. Cellular apoptosis and inflammatory markers were evaluated in NRK-52E cells and mouse primary tubular cells after hypoxia and reoxygenation using a hypoxia work station.
Results
Following IR injury in diabetic mice, the expression of PDK4, rather than the other PDK isoforms, was induced with a marked increase in pyruvate dehydrogenase E1α (PDHE1α) phosphorylation. This was accompanied by a pronounced ROS activation, as well as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) production. Notably, sodium dichloroacetate (DCA) attenuated renal IR injury-induced apoptosis which can be attributed to reducing PDK4 expression and PDHE1α phosphorylation levels. DCA or shPdk4 treatment reduced oxidative stress and decreased TNF-α, IL-6, IL-1β, and MCP-1 production after IR or hypoxia-reoxygenation injury.
Conclusion
PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.

Citations

Citations to this article as recorded by  
  • Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury
    Jaemin Lee
    Diabetes & Metabolism Journal.2024; 48(3): 385.     CrossRef
  • Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
    Seahyoung Lee
    Antioxidants.2024; 13(6): 656.     CrossRef
Review
Basic Research
The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
Diabetes Metab J. 2020;44(2):222-233.   Published online April 23, 2020
DOI: https://doi.org/10.4093/dmj.2020.0053
  • 8,985 View
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  • 21 Web of Science
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AbstractAbstract PDFPubReader   

Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for decades, but not yet fully understood. Fatty acid translocase cluster determinant 36 (CD36), which is part of the free fatty acid (FFA) transporter system, has been identified in several tissues such as muscle, liver, and insulin-producing cells. Several studies have reported that induction of CD36 increases uptake of FFA in several cells, suggesting the functional interplay between glucose and FFA in terms of insulin secretion and oxidative metabolism. However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. Also, the downstream and upstream targets of CD36 related signaling have not been defined. In the present review, we will focus on the expression and function of CD36 related signaling in the pancreatic β-cells in response to hyperglycemia and hyperlipidemia (ceramide) along with the clinical studies on the association between CD36 and metabolic disorders.

Citations

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  • CD36 inhibition corrects lipid-FetuinA mediated insulin secretory defects by preventing intracellular lipid accumulation and inflammation in the pancreatic beta cells
    Samanwita Mandal, Snehasish Nag, Oindrila Mukherjee, Nandita Das, Priyajit Banerjee, Tanmay Majumdar, Satinath Mukhopadhyay, Kathrin Maedler, Rakesh Kundu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2025; 1871(2): 167580.     CrossRef
  • Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
    Alpana Mukhuty, Samanwita Mandal, Chandrani Fouzder, Snehasis Das, Dipanjan Chattopadhyay, Tanmay Majumdar, Rakesh Kundu
    Molecular and Cellular Endocrinology.2024; 581: 112112.     CrossRef
  • CD36 gene variant rs1761667(G/A) as a biomarker in obese type 2 diabetes mellitus cases
    Ashwin Kumar Shukla, Amreen Shamsad, Atar Singh Kushwah, Shalini Singh, Kauser Usman, Monisha Banerjee
    Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
  • CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis
    Xiang Zhang, Catherine King, Alexander Dowell, Paul Moss, Lorraine Harper, Dimitrios Chanouzas, Xiong-zhong Ruan, Alan David Salama
    Clinical Immunology.2024; 260: 109914.     CrossRef
  • Identification and validation of oxidative stress-related genes in sepsis-induced myopathy
    Ning Zhang, Dan Huang, Xiang Li, JinXia Yan, Qi Yan, WeiXing Ge, Jun Zhou
    Medicine.2024; 103(18): e37933.     CrossRef
  • Monocyte CD36 Expression Predicts Disease Activity in Patients With Crohn’s Disease
    Jiejie Zhu, Nannan Zhu, Jiren Wang, Qiuyuan Liu, Qiao Mei, Andrew S. Day
    Gastroenterology Research and Practice.2024;[Epub]     CrossRef
  • The identification of key genes and pathways in polycystic ovary syndrome by bioinformatics analysis of next-generation sequencing data
    Varun Alur, Basavaraj Vastrad, Varshita Raju, Chanabasayya Vastrad, Shivakumar Kotturshetti
    Middle East Fertility Society Journal.2024;[Epub]     CrossRef
  • The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target
    Yun Li, Yaxi Chen, Xiong Z. Ruan
    Pediatric Discovery.2023;[Epub]     CrossRef
  • The role of candidate transport proteins in β‐cell long‐chain fatty acid uptake: Where are we now?
    Christina Clavelo‐Farrow, Patricia Thomas
    Diabetic Medicine.2023;[Epub]     CrossRef
  • SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
    Ningfei Ji, Mingshun Zhang, Liang Ren, Yunyun Wang, Bicheng Hu, Jie Xiang, Yingyun Gong, Chaojie Wu, Guoqiang Qu, Wenqiu Ding, Zhiqiang Yin, Shan Li, Zhengxia Wang, Lianzheng Zhou, Xueqin Chen, Yuan Ma, Jinhai Tang, Yun Liu, Liang Liu, Mao Huang
    Emerging Microbes & Infections.2022; 11(1): 1115.     CrossRef
  • Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
    Diabetes Research and Clinical Practice.2022; 189: 109939.     CrossRef
  • Lipotoxicity in a Vicious Cycle of Pancreatic Beta Cell Exhaustion
    Vladimir Grubelnik, Jan Zmazek, Matej Završnik, Marko Marhl
    Biomedicines.2022; 10(7): 1627.     CrossRef
  • Association of cluster determinant 36, scavenger receptor class B type 1, and major facilitator superfamily domain containing the 2a genetic polymorphism with serum lipid profile in aging population with type 2 diabetes mellitus
    Xixiang Wang, Xiaojun Ma, Jingjing Xu, Yujie Guo, Shaobo Zhou, Huiyan Yu, Linhong Yuan
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
    Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean-Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Wan-Hee Cheng, Kok-Song Lai, Nik Mohd Afizan Nik Abd Rahman
    Cells.2022; 11(22): 3556.     CrossRef
  • The Past and Present Lives of the Intraocular Transmembrane Protein CD36
    Rucui Yang, Qingping Liu, Mingzhi Zhang
    Cells.2022; 12(1): 171.     CrossRef
  • Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
    Sachin Kumar, Tapan Behl, Monika Sachdeva, Aayush Sehgal, Shilpa Kumari, Arun Kumar, Gagandeep Kaur, Harlokesh Narayan Yadav, Simona Bungau
    Life Sciences.2021; 264: 118661.     CrossRef
  • Contribution of rs3211938 polymorphism at CD36 to glucose levels, oxidized low-density lipoproteins, insulin resistance, and body mass index in Mexican mestizos with type-2 diabetes from western Mexico
    Beatriz Teresita Martín-Márquez, Flavio Sandoval-Garcia, Mónica Vazquez-Del Mercado, Erika-Aurora Martínez-García, Fernanda-Isadora Corona-Meraz, Ana-Lilia Fletes-Rayas, Soraya-Amalí Zavaleta-Muñiz
    Nutrición Hospitalaria.2021;[Epub]     CrossRef
  • Investigating the association of CD36 gene polymorphisms (rs1761667 and rs1527483) with T2DM and dyslipidemia: Statistical analysis, machine learning based prediction, and meta-analysis
    Ma’mon M. Hatmal, Walhan Alshaer, Ismail S. Mahmoud, Mohammad A. I. Al-Hatamleh, Hamzeh J. Al-Ameer, Omar Abuyaman, Malek Zihlif, Rohimah Mohamud, Mais Darras, Mohammad Al Shhab, Rand Abu-Raideh, Hilweh Ismail, Ali Al-Hamadi, Ali Abdelhay, Kanhaiya Singh
    PLOS ONE.2021; 16(10): e0257857.     CrossRef
  • Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
    Mustafa Karabicici, Yagmur Azbazdar, Evin Iscan, Gunes Ozhan
    Membranes.2021; 11(11): 844.     CrossRef
  • CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting
    Udayakumar Karunakaran, Suma Elumalai, Jun-Sung Moon, Kyu-Chang Won
    Cells.2021; 10(7): 1833.     CrossRef
Original Article
Basic Research
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Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy
Chang-Yun Woo, Ji Yeon Baek, Ah-Ram Kim, Chung Hwan Hong, Ji Eun Yoon, Hyoun Sik Kim, Hyun Ju Yoo, Tae-Sik Park, Ranjan Kc, Ki-Up Lee, Eun Hee Koh
Diabetes Metab J. 2020;44(4):581-591.   Published online November 4, 2019
DOI: https://doi.org/10.4093/dmj.2019.0063
  • 7,377 View
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  • 33 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Ceramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also, mitochondrial dysfunction is known to be an early event in podocyte injury. Thus, we tested the hypothesis that ceramide accumulation in podocytes induces mitochondrial damage through reactive oxygen species (ROS) production in patients with diabetic nephropathy.

Methods

We used Otsuka Long Evans Tokushima Fatty (OLETF) rats and high-fat diet (HFD)-fed mice. We fed the animals either a control- or a myriocin-containing diet to evaluate the effects of the ceramide. Also, we assessed the effects of ceramide on intracellular ROS generation and on podocyte autophagy in cultured podocytes.

Results

OLETF rats and HFD-fed mice showed albuminuria, histologic features of diabetic nephropathy, and podocyte injury, whereas myriocin treatment effectively treated these abnormalities. Cultured podocytes exposed to agents predicted to be risk factors (high glucose, high free fatty acid, and angiotensin II in combination [GFA]) showed an increase in ceramide accumulation and ROS generation in podocyte mitochondria. Pretreatment with myriocin reversed GFA-induced mitochondrial ROS generation and prevented cell death. Myriocin-pretreated cells were protected from GFA-induced disruption of mitochondrial integrity.

Conclusion

We showed that mitochondrial ceramide accumulation may result in podocyte damage through ROS production. Therefore, this signaling pathway could become a pharmacological target to abate the development of diabetic kidney disease.

Citations

Citations to this article as recorded by  
  • Interplay of lipid metabolism and inflammation in podocyte injury
    Zilv Luo, Zhaowei Chen, Jijia Hu, Guohua Ding
    Metabolism.2024; 150: 155718.     CrossRef
  • Associations of plasma sphingolipids with measures of insulin sensitivity, β-cell function, and incident diabetes in Japanese Americans
    Ji Cheol Bae, Pandora L. Wander, Rozenn N. Lemaitre, Amanda M. Fretts, Colleen M. Sitlani, Hai H. Bui, Melissa K. Thomas, Donna Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko, Kristina M. Utzschneider
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 633.     CrossRef
  • A review of the mechanisms of abnormal ceramide metabolism in type 2 diabetes mellitus, Alzheimer’s disease, and their co-morbidities
    Yun Pan, Jieying Li, Panjie Lin, Lihua Wan, Yiqian Qu, Lingyong Cao, Lei Wang
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Ceramides and mitochondrial homeostasis
    Song Ding, Guorui Li, Tinglv Fu, Tianyu Zhang, Xiao Lu, Ning Li, Qing Geng
    Cellular Signalling.2024; 117: 111099.     CrossRef
  • The Influence of Soy Isoflavones and Soy Isoflavones with Inulin on Kidney Morphology, Fatty Acids, and Associated Parameters in Rats with and without Induced Diabetes Type 2
    Kamila Misiakiewicz-Has, Dominika Maciejewska-Markiewicz, Dagmara Szypulska-Koziarska, Agnieszka Kolasa, Barbara Wiszniewska
    International Journal of Molecular Sciences.2024; 25(10): 5418.     CrossRef
  • Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice
    Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus
    Scientific Reports.2024;[Epub]     CrossRef
  • Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy
    Yichen Yang, Jiahui Liu, Qiling Shi, Buyu Guo, Hanbing Jia, Yuxuan Yang, Songbo Fu
    Biomolecules.2024; 14(6): 733.     CrossRef
  • Lipidomic study of kidney in a mouse model with urine flow obstruction
    Divyavani Gowda, Md. Abdul Masum, Siddabasave Gowda B. Gowda, Chandra Shekhar, Md. Zahir Uddin Rubel, Shunnosuke Kira, Osamu Ichii, Yasuhiro Kon, Hitoshi Chiba, Shu-Ping Hui
    Scientific Reports.2024;[Epub]     CrossRef
  • Sphingolipids and Chronic Kidney Disease
    Zrinka Šakić, Armin Atić, Slavica Potočki, Nikolina Bašić-Jukić
    Journal of Clinical Medicine.2024; 13(17): 5050.     CrossRef
  • A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling
    Yinghong Liu, Xiaojuan Yang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity
    Nathaniel L. Hepowit, Eric Blalock, Sangderk Lee, Kimberly M. Bretland, Jason A. MacGurn, Robert C. Dickson
    Aging.2023; 15(2): 472.     CrossRef
  • Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction
    Peng Liu, Yao Chen, Jing Xiao, Wenhui Zhu, Xiaoming Yan, Ming Chen
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
    Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li,
    EMBO Molecular Medicine.2023;[Epub]     CrossRef
  • Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease
    Peng Liu, Wenhui Zhu, Yang Wang, Guijie Ma, Hailing Zhao, Ping Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Integrated gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐mass spectrometry renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney‐yang‐deficiency‐syndrome rats
    Qing Lu, Jing Zhang, Ling Xin, Yanwei Lou, Feng Qin, Longshan Zhao, Zhili Xiong
    Journal of Separation Science.2023;[Epub]     CrossRef
  • Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress
    Ming Chen, Yao Chen, Wenhui Zhu, Xiaoming Yan, Jing Xiao, Peiqing Zhang, Peng Liu, Ping Li
    Biomedicine & Pharmacotherapy.2023; 165: 115088.     CrossRef
  • Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy
    Amit Talukdar, Mandira Basumatary
    Molecular Biology Reports.2023; 50(9): 7759.     CrossRef
  • Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
    Nathaniel L. Hepowit, Bradley Moon, Adam C. Ebert, Robert C. Dickson, Jason A. MacGurn
    Journal of Cell Science.2023;[Epub]     CrossRef
  • Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
    Alla Mitrofanova, Sandra Merscher, Alessia Fornoni
    Nature Reviews Nephrology.2023; 19(10): 629.     CrossRef
  • Research progress of autophagy in pathogenesis of diabetes nephropathy
    Shengnan Zeng, Ying Li
    Diabetic Nephropathy.2023; 3(3): 51.     CrossRef
  • Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease
    Judy Baek, Chenchen He, Farsad Afshinnia, George Michailidis, Subramaniam Pennathur
    Nature Reviews Nephrology.2022; 18(1): 38.     CrossRef
  • Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria
    Irena Audzeyenka, Agnieszka Bierżyńska, Abigail C Lay
    Endocrinology.2022;[Epub]     CrossRef
  • Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?
    Xiaodie Mu, Min Yang, Peiyao Ling, Aihua Wu, Hua Zhou, Jingting Jiang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 247.     CrossRef
  • Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
    Jinshan He, Sicong Li, Yumeng Ding, Yujia Tong, Xuebin Li, Simona Saponara
    Cardiovascular Therapeutics.2022; 2022: 1.     CrossRef
  • Mechanisms of podocyte injury and implications for diabetic nephropathy
    Federica Barutta, Stefania Bellini, Gabriella Gruden
    Clinical Science.2022; 136(7): 493.     CrossRef
  • A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
    Norishi Ueda
    International Journal of Molecular Sciences.2022; 23(7): 4010.     CrossRef
  • Implications of Sphingolipid Metabolites in Kidney Diseases
    Shamroop kumar Mallela, Sandra Merscher, Alessia Fornoni
    International Journal of Molecular Sciences.2022; 23(8): 4244.     CrossRef
  • Role of ceramides in the pathogenesis of diabetes mellitus and its complications
    Nawajes Mandal, Richard Grambergs, Koushik Mondal, Sandip K. Basu, Faiza Tahia, Sam Dagogo-Jack
    Journal of Diabetes and its Complications.2021; 35(2): 107734.     CrossRef
  • Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease
    Rebekah J. Nicholson, Marcus G. Pezzolesi, Scott A. Summers
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools
    Nathaniel L. Hepowit, Jessica K. A. Macedo, Lyndsay E. A. Young, Ke Liu, Ramon C. Sun, Jason A. MacGurn, Robert C. Dickson
    Aging.2021; 13(6): 7846.     CrossRef
  • New insights into renal lipid dysmetabolism in diabetic kidney disease
    Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
    World Journal of Diabetes.2021; 12(5): 524.     CrossRef
  • Excessively Enlarged Mitochondria in the Kidneys of Diabetic Nephropathy
    Kiyoung Kim, Eun-Young Lee
    Antioxidants.2021; 10(5): 741.     CrossRef
  • Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review
    Saba Noor, Taj Mohammad, Gulam M. Ashraf, Joviana Farhat, Anwar L. Bilgrami, Mathew Suji Eapen, Sukhwinder Singh Sohal, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
    International Journal of Biological Macromolecules.2021; 193: 562.     CrossRef
  • The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
    Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
    Kidney Diseases.2021; 7(6): 438.     CrossRef
  • Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1
    Benoit Denhez, Marina Rousseau, Crysta Spino, David-Alexandre Dancosst, Marie-Ève Dumas, Andréanne Guay, Farah Lizotte, Pedro Geraldes
    Scientific Reports.2020;[Epub]     CrossRef
Reviews
Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue
Chang Yeop Han
Diabetes Metab J. 2016;40(4):272-279.   Published online June 28, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.4.272
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  • 118 Web of Science
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AbstractAbstract PDFPubReader   

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive oxygen species (ROS) have been implicated as contributors to both the onset and the progression of insulin resistance. ROS can be generated by overloading the mitochondrial oxidative phosphorylation system, and also by nicotinamide adenine dinucleotide phosphate oxidases (NOX) produced by either adipocytes, which only produce NOX4, or by macrophages, which produce mainly NOX2. The source of the ROS might differ in the early, intermediate and late stages of obesity, switching from NOX4-dependence in the early phases to NOX2-dependence, in the intermediate phase, and transiting to mitochondria-dependence later in the time course of obesity. Thus, depending on the stage of obesity, ROS can be generated by three distinct mechanisms: i.e., NOX4, NOX2, and mitochondria. In this review, we will discuss whether NOX4-, NOX2-, and/or mitochondria-derived ROS is/are causal in the onset of adipocyte insulin resistance as obesity progresses. Moreover, we will review the pathophysiological roles of NOX4, NOX2, and mitochondria-derived ROS on adipose tissue inflammation.

Citations

Citations to this article as recorded by  
  • The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
    Mikiko Shibata, Kyoko Kogawa Sato, Hideo Koh, Izumi Shibata, Kaori Okamura, Yuka Takeuchi, Keiko Oue, Michio Morimoto, Tomoshige Hayashi
    Journal of Epidemiology.2024; 34(3): 137.     CrossRef
  • Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity
    J. P. Shirley Niveta, Cordelia Mano John, Sumathy Arockiasamy
    Molecular Biology Reports.2024;[Epub]     CrossRef
  • The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
    Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
    Seminars in Cancer Biology.2024; 99: 24.     CrossRef
  • Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
    Fani-Niki Varra, Michail Varras, Viktoria-Konstantina Varra, Panagiotis Theodosis‑Nobelos
    Molecular Medicine Reports.2024;[Epub]     CrossRef
  • Pathogenesis and management of diabetic gastroparesis: An updated clinically oriented review
    Srikar Uppaluri, Manisha Ashok Jain, Hira Ali, Jay Shingala, Dhruti Amin, Trisha Ajwani, Irum Fatima, Neil Patel, Nirja Kaka, Yashendra Sethi, Nitin Kapoor
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(3): 102994.     CrossRef
  • The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
    Helen Ye Rim Huang, Sarah Badar, Mohammad Said, Siddiqah Shah, Hareesha Rishab Bharadwaj, Krishna Ramamoorthy, Maen Monketh Alrawashdeh, Faaraea Haroon, Jawad Basit, Sajeel Saeed, Narjiss Aji, Gary Tse, Priyanka Roy, Mainak Bardhan
    Molecular Biology Reports.2024;[Epub]     CrossRef
  • The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids
    Angelina Passaro, Juana Maria Sanz, Nenad Naumovski, Domenico Sergi
    Advances in Redox Research.2024; 11: 100100.     CrossRef
  • The Interplay between Obesity and Inflammation
    Ilinca Savulescu-Fiedler, Razvan Mihalcea, Serban Dragosloveanu, Cristian Scheau, Radu Octavian Baz, Ana Caruntu, Andreea-Elena Scheau, Constantin Caruntu, Serban Nicolae Benea
    Life.2024; 14(7): 856.     CrossRef
  • Dietary fatty acid pattern and its association with metabolic profile among overweight and obese adults
    Reyhaneh Mokhtari Hemami, Mahdieh Abbasalizad Farhangi, Mohammad Dehghan Rouzi, Fatemeh Abdi
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • Anti-diabetic effects of marine natural products through redox modulation via Nrf2/HO-1 cytoprotective pathways
    Muhammad Farrukh Nisar, Mingxi Li, Jialin Xu, Chunpeng Wan
    Frontiers in Marine Science.2024;[Epub]     CrossRef
  • Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases
    Biao Li, Wan Li, Tiancai Liu, Longying Zha
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Oxidative stress in metabolic diseases: current scenario and therapeutic relevance
    Satish K. Raut, Madhu Khullar
    Molecular and Cellular Biochemistry.2023; 478(1): 185.     CrossRef
  • Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities
    Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d’Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi
    Nutrients.2023; 15(4): 829.     CrossRef
  • Current Status of Obesity: Protective Role of Catechins
    Tanisha Basu, Ashley Selman, Arubala P. Reddy, P. Hemachandra Reddy
    Antioxidants.2023; 12(2): 474.     CrossRef
  • Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation
    Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama
    Toxins.2023; 15(3): 179.     CrossRef
  • The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
    Iwona Świątkiewicz, Marcin Wróblewski, Jarosław Nuszkiewicz, Paweł Sutkowy, Joanna Wróblewska, Alina Woźniak
    International Journal of Molecular Sciences.2023; 24(7): 6382.     CrossRef
  • Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism
    S.G. Chowdhury, S. Misra, Parimal Karmakar
    The Journal of nutrition, health and aging.2023; 27(5): 314.     CrossRef
  • Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis
    Priyanshy Sharma, V. Sri Swetha Victoria, P. Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Reddy
    International Immunopharmacology.2023; 122: 110472.     CrossRef
  • Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies
    D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
    Applied Biochemistry and Microbiology.2023; 59(6): 754.     CrossRef
  • Mechanism and application of Lactobacillus in type 2 diabetes-associated periodontitis
    Sisi Chen, Yuhan Zhang
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Mechanisms of Formation and Persistence of Ige Products and Potential Innovative Means of Therapy for Allergic Pathologies
    D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
    Прикладная биохимия и микробиология.2023; 59(6): 538.     CrossRef
  • Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
    Siphamandla R. Ngcobo, Bongani B. Nkambule, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Aviwe Ntsethe, Vuyolwethu Mxinwa, Khanyisani Ziqubu, Yonela Ntamo, Thembeka A. Nyawo, Phiwayinkosi V. Dludla
    Biomedicine & Pharmacotherapy.2022; 146: 112579.     CrossRef
  • Genomic Analysis of Visceral Fat Accumulation in Holstein Cows
    Larissa C. Novo, Ligia Cavani, Pablo Pinedo, Pedro Melendez, Francisco Peñagaricano
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Regulation of immune cell function by nicotinamide nucleotide transhydrogenase
    Thomas Regan, Rachel Conway, Leena P. Bharath
    American Journal of Physiology-Cell Physiology.2022; 322(4): C666.     CrossRef
  • d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
    Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
    Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
  • Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets
    Sinenhlanhla X.H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Khanyisani Ziqubu, Thembeka A. Nyawo, Nnini Obonye, Tawanda M. Nyambuya, Bongani B. Nkambule, Sonia Silvestri, Luca Tiano, Christo J.F. Muller, Phiwayinkosi V. Dludla
    Life Sciences.2022; 297: 120467.     CrossRef
  • The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity
    Judy Fieres, Marvin Fischer, Christine Sauter, Maria Moreno-Villanueva, Alexander Bürkle, Petra H. Wirtz
    DNA Repair.2022; 114: 103323.     CrossRef
  • The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
    Anushka C. Wickramaratne, Li Li, Jesse B. Hopkins, Lukasz A. Joachimiak, Carla B. Green
    Biochemistry.2022; 61(11): 1091.     CrossRef
  • Oxidative stress and obesity
    Maja Malenica, Neven Meseldžić
    Arhiv za farmaciju.2022; 72(2): 166.     CrossRef
  • Transcriptomic analysis of Simpson Golabi Behmel Syndrome cells during differentiation exhibit BAT-like function
    M. Colitti, U. Ali, M. Wabitsch, D. Tews
    Tissue and Cell.2022; : 101822.     CrossRef
  • Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials
    Sebastián Yalle-Vásquez, Karem Osco-Rosales, Wendy Nieto-Gutierrez, Vicente Benites-Zapata, Faustino R. Pérez-López, Christoper A. Alarcon-Ruiz
    Gynecological Endocrinology.2022; 38(7): 548.     CrossRef
  • The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity
    Orestes López-Ortega, Nidia Carolina Moreno-Corona, Victor Javier Cruz-Holguin, Luis Didier Garcia-Gonzalez, Addy Cecilia Helguera-Repetto, Mirza Romero-Valdovinos, Haruki Arevalo-Romero, Leticia Cedillo-Barron, Moisés León-Juárez
    International Journal of Molecular Sciences.2022; 23(11): 6154.     CrossRef
  • Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review
    Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Nilmara Cunha da
    Biological Trace Element Research.2022; 200(8): 3545.     CrossRef
  • Nrf2a dependent and independent effects of early life exposure to 3,3’-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio)
    Monika A. Roy, Charlotte K. Gridley, Sida Li, Yeonhwa Park, Alicia R. Timme-Laragy
    Aquatic Toxicology.2022; 249: 106219.     CrossRef
  • Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats
    Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Sheu Oluwadare Sulaiman, Edwin Coleridge Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu
    IBRO Neuroscience Reports.2022; 13: 57.     CrossRef
  • Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
    Chung-Lin Jiang, Chang-Yu Tsao, Yi-Ching Lee
    Genes & Nutrition.2022;[Epub]     CrossRef
  • Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
    Xiujuan Wang, Meihong Xu, Yong Li
    Nutrients.2022; 14(15): 3134.     CrossRef
  • Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis
    Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Kharitonova, Sergey L. Andreev, Alexander S. Gorbunov, Boris K. Kurbatov, Alla A. Boshchenko
    Biomedicines.2022; 10(8): 2054.     CrossRef
  • Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer
    Konstantinos Prokopidis, Panagiotis Giannos, Oliver C. Witard, Daniel Peckham, Theocharis Ispoglou, Ajay Pratap Singh
    PLOS ONE.2022; 17(9): e0273766.     CrossRef
  • Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress
    Mark F. McCarty, James J. DiNicolantonio, James H. O’Keefe
    Current Issues in Molecular Biology.2022; 44(9): 4314.     CrossRef
  • Fructose promotes more than glucose the adipocytic differentiation of pig mesenchymal stem cells
    Francisco Campos‐Maldonado, María L. González‐Dávalos, Enrique Piña, Miriam Aracely Anaya‐Loyola, Armando Shimada, Alfredo Varela‐Echavarria, Ofelia Mora
    Journal of Food Biochemistry.2022;[Epub]     CrossRef
  • Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management?
    Antonio Matrone, Alessio Basolo, Ferruccio Santini, Rossella Elisei
    Expert Review of Endocrinology & Metabolism.2022; 17(6): 475.     CrossRef
  • The Role of Inflammation as a Preponderant Risk Factor in Cardiovascular Diseases
    Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de los Ángeles Peral
    Current Vascular Pharmacology.2022; 20(3): 244.     CrossRef
  • Synthesis and Catalytic Studies of Nanoalloy Particles Based on Bismuth, Silver, and Rhenium
    Konrad Wojtaszek, Katarzyna Skibińska, Filip Cebula, Tomasz Tokarski, Marc Escribà-Gelonch, Volker Hessel, Marek Wojnicki
    Metals.2022; 12(11): 1819.     CrossRef
  • Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review
    Francesco Nappi, Antonio Fiore, Joyce Masiglat, Teresa Cavuoti, Michela Romandini, Pierluigi Nappi, Sanjeet Singh Avtaar Singh, Jean-Paul Couetil
    Biomedicines.2022; 10(11): 2884.     CrossRef
  • MicroRNAs in the Regulation of NADPH Oxidases in Vascular Diabetic and Ischemic Pathologies: A Case for Alternate Inhibitory Strategies?
    Sean R. Wallace, Patrick J. Pagano, Damir Kračun
    Antioxidants.2022; 12(1): 70.     CrossRef
  • Nanopolyphenols
    Priyanka Rathod, Raman P. Yadav
    MGM Journal of Medical Sciences.2022; 9(3): 419.     CrossRef
  • Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance
    Yujeong Kim, Ok-Kyung Kim
    Advances in Nutrition.2021; 12(2): 566.     CrossRef
  • Mesenchymal stem cell conditioned medium ameliorates diabetic serum‐induced insulin resistance in 3T3‐L1 cells
    Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
    Chronic Diseases and Translational Medicine.2021; 7(1): 47.     CrossRef
  • F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes
    M. T. Kaartinen, M. Arora, S. Heinonen, A. Hang, A. Barry, J. Lundbom, A. Hakkarainen, N. Lundholm, A. Rissanen, J. Kaprio, K. H. Pietiläinen
    International Journal of Obesity.2021; 45(3): 577.     CrossRef
  • Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer – Pooled results of 24 million cohorts
    Mohanad R. Youssef, Adin S.C. Reisner, Abdallah S. Attia, Mohamed Hosny Hussein, Mahmoud Omar, Anna LaRussa, Carlos A. Galvani, Mohamed Aboueisha, Mohamed Abdelgawad, Eman Ali Toraih, Gregory W. Randolph, Emad Kandil
    Oral Oncology.2021; 112: 105085.     CrossRef
  • Thioredoxin deficiency exacerbates vascular dysfunction during diet‐induced obesity in small mesenteric artery in mice
    Shannon Dunn, Robert H. Hilgers, Kumuda C. Das
    Microcirculation.2021;[Epub]     CrossRef
  • Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes
    Mariana Grancieri, Hércia Stampini Duarte Martino, Elvira Gonzalez de Mejia
    Nutrients.2021; 13(1): 176.     CrossRef
  • The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
    Yawen Zhou, Huige Li, Ning Xia
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
    Safaa H. Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H. Eid, Assaad A. Eid, Ahmed F. El-Yazbi
    Biochemical Pharmacology.2021; 186: 114491.     CrossRef
  • Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents
    Li Xiao, Nobuhiko Miwa
    Cells.2021; 10(3): 626.     CrossRef
  • Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
    Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá
    Antioxidants.2021; 10(4): 526.     CrossRef
  • Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes
    Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu
    Redox Biology.2021; 41: 101948.     CrossRef
  • Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
    Mark F. McCarty
    International Journal of Molecular Sciences.2021; 22(7): 3321.     CrossRef
  • Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
    Pamela A. Nono Nankam, Télesphore B. Nguelefack, Julia H. Goedecke, Matthias Blüher
    Antioxidants.2021; 10(4): 622.     CrossRef
  • Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats
    Joanna Sadowska, Wioleta Dudzińska, Izabela Dziaduch, Mahmoud A.O. Dawood
    PLOS ONE.2021; 16(5): e0251789.     CrossRef
  • Oxidative stress in oocyte aging and female reproduction
    Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
    Journal of Cellular Physiology.2021; 236(12): 7966.     CrossRef
  • Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
    Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
    BioFactors.2021; 47(5): 837.     CrossRef
  • Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
    Letícia Mattei, Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Junio Togneri Ferron, Carol Cristina Vágula de Almeida Silva, Cristina Schmitt Gregolin, Erika Tiemi Nakandakare-Maia, Janaína das Chagas Paixão Silva, Fernando Moreto, Igo
    Molecular and Cellular Endocrinology.2021; 537: 111423.     CrossRef
  • Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses
    Lovro Žiberna, Zala Jenko-Pražnikar, Ana Petelin
    Antioxidants.2021; 10(9): 1352.     CrossRef
  • The level of reactive oxygen species production by adipocytes of epicardial adipose tissue is associated with an increase in postprandial glycemia in patients with severe coronary atherosclerosis
    O. A. Koshelskaya, N. V. Naryzhnaya, I. V. Kologrivova, T. E. Suslova, O. A. Kharitonova, V. V. Evtushenko, S. L. Andreev, A. S. Gorbunov, A. A. Gudkova
    The Siberian Journal of Clinical and Experimental Medicine.2021; 36(3): 59.     CrossRef
  • Untargeted Metabolomic Approach Shows No Differences in Subcutaneous Adipose Tissue of Diabetic and Non-Diabetic Subjects Undergoing Bariatric Surgery: An Exploratory Study
    Carlotta Vizioli, Rosario B. Jaime-Lara, Alexis T. Franks, Rodrigo Ortiz, Paule V. Joseph
    Biological Research For Nursing.2021; 23(1): 109.     CrossRef
  • Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
    Amy E. Mendham, Steen Larsen, Cindy George, Kevin Adams, Jon Hauksson, Tommy Olsson, Melony C. Fortuin-de Smidt, Pamela A. Nono Nankam, Olah Hakim, Louise M. Goff, Carmen Pheiffer, Julia H. Goedecke
    Scientific Reports.2020;[Epub]     CrossRef
  • Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes
    Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Seung-Soon Im, Jae-Hoon Bae, Dae-Kyu Song
    Redox Biology.2020; 37: 101749.     CrossRef
  • Pathogenic Role of Air Pollution Particulate Matter in Cardiometabolic Disease: Evidence from Mice and Humans
    Timoteo Marchini, Andreas Zirlik, Dennis Wolf
    Antioxidants & Redox Signaling.2020; 33(4): 263.     CrossRef
  • Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte
    Allison M. Manuel, Michael D. Walla, Margaret T. Dorn, Ross M. Tanis, Gerardo G. Piroli, Norma Frizzell
    Free Radical Biology and Medicine.2020; 148: 70.     CrossRef
  • TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women
    Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka
    Molecular Biology Reports.2020; 47(2): 855.     CrossRef
  • Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows
    G. Andres Contreras, Jenne De Koster, Jonas de Souza, Juliana Laguna, Vengai Mavangira, Rahul K. Nelli, Jeff Gandy, Adam L. Lock, Lorraine M. Sordillo
    Journal of Dairy Science.2020; 103(2): 1944.     CrossRef
  • Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
    Bianka Bojková, Pawel J. Winklewski, Magdalena Wszedybyl-Winklewska
    International Journal of Molecular Sciences.2020; 21(11): 4114.     CrossRef
  • Adipose tissue macrophages: Unique polarization and bioenergetics in obesity
    Heather L. Caslin, Monica Bhanot, W. Reid Bolus, Alyssa H. Hasty
    Immunological Reviews.2020; 295(1): 101.     CrossRef
  • Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases
    Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
    European Journal of Pharmacology.2020; 881: 173215.     CrossRef
  • Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro
    María Herranz-López, Mariló Olivares-Vicente, Esther Rodríguez Gallego, Jose Antonio Encinar, Almudena Pérez-Sánchez, Verónica Ruiz-Torres, Jorge Joven, Enrique Roche, Vicente Micol
    Food and Chemical Toxicology.2020; 144: 111606.     CrossRef
  • Elastin-derived peptide VGVAPG decreases differentiation of mouse embryo fibroblast (3T3-L1) cells into adipocytes
    Konrad A. Szychowski, Bartosz Skóra, Jakub Tobiasz, Jan Gmiński
    Adipocyte.2020; 9(1): 234.     CrossRef
  • Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications
    John O. Orgah, Shuang He, Yule Wang, Miaomiao Jiang, Yuefei Wang, Emmanuel A. Orgah, Yajun Duan, Buchang Zhao, Boli Zhang, Jihong Han, Yan Zhu
    Pharmacological Research.2020; 153: 104654.     CrossRef
  • Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
    Teresa Vezza, Zaida Abad-Jiménez, Miguel Marti-Cabrera, Milagros Rocha, Víctor Manuel Víctor
    Antioxidants.2020; 9(9): 848.     CrossRef
  • Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
    Mari T. Kaartinen, Mansi Arora, Sini Heinonen, Aila Rissanen, Jaakko Kaprio, Kirsi H. Pietiläinen
    International Journal of Molecular Sciences.2020; 21(21): 8289.     CrossRef
  • Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders
    Teresa Vezza, Francisco Canet, Aranzazu M. de Marañón, Celia Bañuls, Milagros Rocha, Víctor Manuel Víctor
    Antioxidants.2020; 9(12): 1266.     CrossRef
  • Metabolic programming of macrophage functions and pathogens control
    Sue-jie Koo, Nisha J. Garg
    Redox Biology.2019; 24: 101198.     CrossRef
  • Effects of bariatric surgery on telomere length and T-cell aging
    F. Jongbloed, R. W. J. Meijers, J. N. M. IJzermans, R. A. Klaassen, M. E. T. Dollé, S. van den Berg, M. G. H. Betjes, R. W. F. de Bruin, E. van der Harst, N. H. R. Litjens
    International Journal of Obesity.2019; 43(11): 2189.     CrossRef
  • Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
    Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder, Michael Berk
    Neuroscience & Biobehavioral Reviews.2019; 107: 862.     CrossRef
  • Adipose oxidative stress and protein carbonylation
    Amy K. Hauck, Yimao Huang, Ann V. Hertzel, David A. Bernlohr
    Journal of Biological Chemistry.2019; 294(4): 1083.     CrossRef
  • Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis
    Priyanka Sarkar, Kavitha Thirumurugan
    Journal of Functional Foods.2019; 53: 318.     CrossRef
  • Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
    Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
    Diabetologia.2019; 62(5): 779.     CrossRef
  • Obesity, DNA Damage, and Development of Obesity-Related Diseases
    Marta Włodarczyk, Grażyna Nowicka
    International Journal of Molecular Sciences.2019; 20(5): 1146.     CrossRef
  • Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
    Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
    Scientific Reports.2019;[Epub]     CrossRef
  • The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology
    Evan DeVallance, Yao Li, Michael J. Jurczak, Eugenia Cifuentes-Pagano, Patrick J. Pagano
    Antioxidants & Redox Signaling.2019; 31(10): 687.     CrossRef
  • Phenolic compounds as natural and multifunctional anti-obesity agents: A review
    Celia Rodríguez-Pérez, Antonio Segura-Carretero, María del Mar Contreras
    Critical Reviews in Food Science and Nutrition.2019; 59(8): 1212.     CrossRef
  • Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C
    Eraci Drehmer, Mari Ángeles Navarro-Moreno, Sandra Carrera, Vincent M. Villar, Mari Luz Moreno
    Food & Function.2019; 10(6): 3567.     CrossRef
  • High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production
    Tareck Rharass, Stéphanie Lucas
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation
    Pratik Adhya, Shyam Sunder Sharma
    Pharmacological Research.2019; 146: 104271.     CrossRef
  • Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
    Maria A. Pabon, Kevin Manocha, Jim W. Cheung, James C. Lo
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Strawberry extract attenuates oxidative stress in 3T3-L1 cells
    Tamara Y. Forbes-Hernández, Sadia Afrin, Danila Cianciosi, Piera Pia Manna, Jiaojiao Zhang, Massimiliano Gasparrini, Patricia Reboredo-Rodríguez
    Journal of Berry Research.2018; 8(3): 193.     CrossRef
  • The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
    Hyon-Seung Yi, Joon Young Chang, Minho Shong
    Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
  • Emerging Roles for Adipose Tissue in Cardiovascular Disease
    Elizabeth E. Ha, Robert C. Bauer
    Arteriosclerosis, Thrombosis, and Vascular Biology.2018;[Epub]     CrossRef
  • miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway
    Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
    Molecular and Cellular Endocrinology.2018; 476: 155.     CrossRef
  • Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
    Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
    Scientific Reports.2018;[Epub]     CrossRef
  • Zanthoxylum ailanthoides Suppresses Oleic Acid‐Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
    Eun-Bin Kwon, Myung-Ji Kang, Soo-Yeon Kim, Yong-Moon Lee, Mi-Kyeong Lee, Heung Joo Yuk, Hyung Won Ryu, Su Ui Lee, Sei-Ryang Oh, Dong-Oh Moon, Hyun-Sun Lee, Mun-Ock Kim, Shao-Hsuan Kao
    Evidence-Based Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet
    Alice Martinic, Javad Barouei, Zach Bendiks, Darya Mishchuk, Dustin D. Heeney, Roy Martin, Maria L. Marco, Carolyn M. Slupsky
    Journal of Proteome Research.2018; 17(8): 2790.     CrossRef
  • The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
    Xuan Wang, Andris Elksnis, Per Wikström, Erik Walum, Nils Welsh, Per-Ola Carlsson, Harald H. H. W. Schmidt
    PLOS ONE.2018; 13(9): e0204271.     CrossRef
  • Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes
    James C Needell, Madalyn N Brown, Danny Zipris
    Journal of Endocrinology.2018; 238(1): 61.     CrossRef
  • Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
    Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers, Jun Ren
    Pharmacology & Therapeutics.2018; 191: 1.     CrossRef
  • Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
    Phiwayinkosi V. Dludla, Bongani B. Nkambule, Babalwa Jack, Zibusiso Mkandla, Tinashe Mutize, Sonia Silvestri, Patrick Orlando, Luca Tiano, Johan Louw, Sithandiwe E. Mazibuko-Mbeje
    Nutrients.2018; 11(1): 23.     CrossRef
  • Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity
    Laura J. Den Hartigh, Mohamed Omer, Leela Goodspeed, Shari Wang, Tomasz Wietecha, Kevin D. O’Brien, Chang Yeop Han
    Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(3): 466.     CrossRef
  • Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue
    Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
    European Journal of Medicinal Chemistry.2017; 135: 77.     CrossRef
  • Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients
    Morana Jaganjac, Shamma Almuraikhy, Fatima Al-Khelaifi, Mashael Al-Jaber, Moataz Bashah, Nayef A. Mazloum, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Wael Kafienah, Mohamed A. Elrayess
    Redox Biology.2017; 12: 483.     CrossRef
  • A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
    Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Endocrinology and Metabolism.2017; 32(3): 375.     CrossRef
  • Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
    Maimaiti Yisireyili, Motoharu Hayashi, Hongxian Wu, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Mohammad Shoaib Hamrah, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita
    Scientific Reports.2017;[Epub]     CrossRef
  • Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress
    Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando Tovar, Nimbe Torres
    Nutrients.2017; 9(4): 393.     CrossRef
  • Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome
    Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
    Metabolism.2017; 71: 132.     CrossRef
  • Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling
    Ann V. Hertzel, Hongliang Xu, Michael Downey, Nicholas Kvalheim, David A. Bernlohr
    Journal of Lipid Research.2017; 58(7): 1354.     CrossRef
  • Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
    Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
    Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
  • Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice
    Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
    Vascular Pharmacology.2017; 96-98: 19.     CrossRef
  • Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
    Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A. Toque, Jijun Chen, Reem T. Atawia, Abdelrahman Y. Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B. Caldwell, Robert W. Caldwell
    Cardiovascular Research.2017; 113(13): 1664.     CrossRef
  • Change in serum albumin concentration is inversely and independently associated with risk of incident metabolic syndrome
    Sang-Man Jin, Yong Joo Hong, Jae Hwan Jee, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
    Metabolism.2016; 65(11): 1629.     CrossRef
A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
Udayakumar Karunakaran, Keun-Gyu Park
Diabetes Metab J. 2013;37(2):106-112.   Published online April 16, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.2.106
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AbstractAbstract PDFPubReader   

A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic β-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and β-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect β-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with β-cell failure.

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  • Association Between Serum Ferritin and the Duration of Type 2 Diabetes Mellitus in a Tertiary Care Hospital in Chennai
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    Cureus.2024;[Epub]     CrossRef
  • Pancreatic Parenchymal Atrophy and Pancreatic Fat Accumulation Measured by Multidetector Computed Tomography as a Stable Marker of Chronic Progressive Type 2 Diabetes Mellitus—A Cross Sectional Observational Study
    Kshipra Devadiga, Khanak K Nandolia, Mahendra Singh, Pankaj Sharma, Udit Chauhan, Ravi Kant
    Avicenna Journal of Medicine.2024; 14(01): 060.     CrossRef
  • Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges
    Jiahan Liu, Chen Wang, Shuo Qiu, Wenqi Sun, Guodong Yang, Lijun Yuan
    ACS Applied Bio Materials.2024; 7(3): 1416.     CrossRef
  • Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes
    Chengmeng Huang, Xiaolin Chen, Zedong Ouyang, Lingxue Meng, Jian Liu, Qihua Pang, Ruifang Fan
    Toxicology in Vitro.2024; 99: 105866.     CrossRef
  • Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
    Aikaterini E. Mantadaki, Manolis Linardakis, Maria Tsakiri, Stella Baliou, Persefoni Fragkiadaki, Elena Vakonaki, Manolis N. Tzatzarakis, Aristidis Tsatsakis, Emmanouil K. Symvoulakis
    Journal of Clinical Medicine.2024; 13(12): 3504.     CrossRef
  • Effect of Vitamin C on Blood Glucose Levels, Glycosylated Hemoglobin, and Serum Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Prospective Study
    Fehmi M. Mukadam, Ujwala P. Gawali, Shraddha M. Pore
    Journal of Diabetology.2024; 15(3): 273.     CrossRef
  • A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke
    Namra Aziz, Pranay Wal, Rishika Sinha, Prashant Ramesh Shirode, GunoSindhu Chakraborthy, Mukesh Chandra Sharma, Pankaj Kumar
    Current Protein & Peptide Science.2024; 25(9): 682.     CrossRef
  • A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin
    Ana María García-Muñoz, Desirée Victoria-Montesinos, Pura Ballester, Begoña Cerdá, Pilar Zafrilla
    Molecules.2024; 29(19): 4576.     CrossRef
  • Exploring the antioxidant properties of semaglutide: A comprehensive review
    Habib Yaribeygi, Mina Maleki, Behina Forouzanmehr, Prashant Kesharwani, Tannaz Jamialahmadi, Sercan Karav, Amirhossein Sahebkar
    Journal of Diabetes and its Complications.2024; 38(12): 108906.     CrossRef
  • Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium
    Asma Bouazza, Eric Fontaine, Xavier Leverve, Elhadj-Ahmed Koceir
    Archives of Physiology and Biochemistry.2023; 129(2): 505.     CrossRef
  • Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H2O2-induced oxidative stress
    Chandan Muddahally Naganna, K. Yogendra Prasad, V. P. Mahendra, P. Ganesan, Ravi Kumar
    Molecular Biology Reports.2023; 50(2): 1311.     CrossRef
  • Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
    Phiwayinkosi V Dludla, Sihle E Mabhida, Khanyisani Ziqubu, Bongani B Nkambule, Sithandiwe E Mazibuko-Mbeje, Sidney Hanser, Albert Kotze Basson, Carmen Pheiffer, Andre Pascal Kengne
    World Journal of Diabetes.2023; 14(3): 130.     CrossRef
  • Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
    Lital Argaev-Frenkel, Tovit Rosenzweig
    Antioxidants.2023; 12(5): 994.     CrossRef
  • Polygenic Variants Linked to Oxidative Stress and the Antioxidant System Are Associated with Type 2 Diabetes Risk and Interact with Lifestyle Factors
    Youngjin Choi, Hyuk-Ku Kwon, Sunmin Park
    Antioxidants.2023; 12(6): 1280.     CrossRef
  • Food Anthocyanins: Malvidin and Its Glycosides as Promising Antioxidant and Anti-Inflammatory Agents with Potential Health Benefits
    Anna Merecz-Sadowska, Przemysław Sitarek, Tomasz Kowalczyk, Karolina Zajdel, Mariusz Jęcek, Paweł Nowak, Radosław Zajdel
    Nutrients.2023; 15(13): 3016.     CrossRef
  • Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
    Luisa B. Maia, Biplab K. Maiti, Isabel Moura, José J. G. Moura
    Molecules.2023; 29(1): 120.     CrossRef
  • Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging
    Ken-ichiro Matsumoto, Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, Ichio Aoki
    Antioxidants & Redox Signaling.2022; 36(1-3): 95.     CrossRef
  • Speciation study and biological activity of copper (II) complexes with picolinic and 6-methylpicolinic acid with different components of blood serum of low molecular mass in KNO3 1.0 mol·L−1 at 25 °C
    Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
    Polyhedron.2022; 211: 115562.     CrossRef
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    Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Hani Al-Salami
    Therapeutic Delivery.2022; 13(1): 51.     CrossRef
  • Racial Differences in Pain, Nutrition, and Oxidative Stress
    Larissa J. Strath, Robert E. Sorge
    Pain and Therapy.2022; 11(1): 37.     CrossRef
  • Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
    Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide
    Bushra Waheed, Syed Muhammad Mukarram Shah, Fida Hussain, Mohammad Ijaz Khan, Anwar Zeb, Muhammad Saeed Jan, Arpita Roy
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles
    Neetu Tripathi, Manoj Kumar Goshisht
    ACS Applied Bio Materials.2022; 5(4): 1391.     CrossRef
  • Chemical speciation, antioxidant activity and molecular docking of copper(II) complexes with pyridinedicarboxylic acids and different ligands of low molecular mass
    Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
    Physics and Chemistry of Liquids.2022; 60(6): 943.     CrossRef
  • Inflammaging and Osteoarthritis
    Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi
    Clinical Reviews in Allergy & Immunology.2022; 64(2): 222.     CrossRef
  • Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation
    Thobekile S. Leyane, Sandy W. Jere, Nicolette N. Houreld
    International Journal of Molecular Sciences.2022; 23(13): 7273.     CrossRef
  • Validation of the traditional medicinal use of a Mexican endemic orchid (Prosthechea karwinskii) through UPLC-ESI-qTOF-MS/MS characterization of its bioactive compounds
    Gabriela Soledad Barragán-Zarate, Luicita Lagunez-Rivera, Rodolfo Solano, Candy Carranza-Álvarez, Diego Manuel Hernández-Benavides, Gerard Vilarem
    Heliyon.2022; 8(7): e09867.     CrossRef
  • N-acetyl-L-cysteine ameliorates hepatocyte pyroptosis of dog type 1 diabetes mellitus via suppression of NLRP3/NF-κB pathway
    Haihua Huo, Haitong Wu, Feiyang Ma, Xinrun Li, Jianzhao Liao, Lianmei Hu, Qingyue Han, Ying Li, Jiaqiang Pan, Hui Zhang, Zhaoxin Tang, Jianying Guo
    Life Sciences.2022; 306: 120802.     CrossRef
  • Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes
    Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
    Environmental Science and Pollution Research.2022; 29(60): 90219.     CrossRef
  • Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale in Streptozotocin-Induced Diabetic Rats
    F. A Bamisaye, R. A Ibrahim, A.O. Sulyman, A.O. Jubril, Olawale Ajuwon
    Nigerian Journal of Physiological Sciences.2022; 37(1): 137.     CrossRef
  • Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats
    Qiang Su, Jing Dong, Donglei Zhang, Lu Yang, Rupak Roy
    Applied Biochemistry and Biotechnology.2022; 194(12): 6407.     CrossRef
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    Biomolecules.2022; 12(10): 1535.     CrossRef
  • Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice
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    Brazilian Journal of Pharmaceutical Sciences.2022;[Epub]     CrossRef
  • Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development
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    Phytotherapy Research.2021; 35(1): 223.     CrossRef
  • Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin
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    Journal of Psychiatric Research.2021; 133: 82.     CrossRef
  • Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice
    Dou Niu, Xue Chen, Ting Wang, Fuxing Wang, Qiusheng Zhang, Xiaochang Xue, Jiefang Kang, Dan Qian Chen
    BioMed Research International.2021; 2021: 1.     CrossRef
  • Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes
    Jiahui Zhang, Fnu Anshul, Deepak K. Malhotra, Juan Jaume, Lance D. Dworkin, Rujun Gong
    Antioxidants.2021; 10(1): 138.     CrossRef
  • p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities
    Yanchao Xu, Yong Wang, Dan Wu, Wenwen He, Liping Wang, Weiming Zhu
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Updated Role of Neuropeptide Y in Nicotine-Induced Endothelial Dysfunction and Atherosclerosis
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    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • IRS‐2/Akt/GSK‐3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity
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    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages
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    Molecules.2021; 26(8): 2198.     CrossRef
  • Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials
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  • Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis
    Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
    Journal of Functional Foods.2021; 87: 104774.     CrossRef
  • The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
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    Antioxidants.2021; 10(11): 1834.     CrossRef
  • Роль системы врождённого иммунитета и окислительного стресса в развитии сахарного диабета 1-типа. Пероксиредоксин 6 как новый антидиабетический препарат
    Е.Г. Новосёлова, О.В. Глушкова, М.О. Хренов, С.М. Лунин, Т.В. Новосёлова, С.Б. Парфенюк
    Биохимия.2021; 86(12): 1840.     CrossRef
  • Role of Innate Immunity and Oxidative Stress in the Development of Type 1 Diabetes Mellitus. Peroxiredoxin 6 as a New Anti-Diabetic Agent
    Elena G. Novoselova, Olga V. Glushkova, Maxim O. Khrenov, Sergey M. Lunin, Tatyana V. Novoselova, Svetlana B. Parfenuyk
    Biochemistry (Moscow).2021; 86(12-13): 1579.     CrossRef
  • Participation of Hsp70 and Hsp90α Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus
    E. G. Novoselova, O. V. Glushkova, M. O. Khrenov, S. B. Parfenyuk, S. M. Lunin, T. V. Novoselova, E. E. Fesenko
    Doklady Biological Sciences.2020; 493(1): 124.     CrossRef
  • The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia
    Sedigheh Shahvali, Armita Shahesmaeili, Mojgan Sanjari, Somayyeh Karami-Mohajeri
    Diabetology International.2020; 11(1): 19.     CrossRef
  • Green synthesis of gold nanoparticles from Fritillaria cirrhosa and its anti-diabetic activity on Streptozotocin induced rats
    Ying Guo, Nan Jiang, Li Zhang, Min Yin
    Arabian Journal of Chemistry.2020; 13(4): 5096.     CrossRef
  • The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases
    Andrés García-Sánchez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations
    Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian, Hani Al-Salami
    Pharmaceutics.2020; 12(8): 708.     CrossRef
  • Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states
    Minglei Ma, Haibin Liu, Jie Yu, Shuli He, Pingping Li, Chunxiao Ma, Huabing Zhang, Lingling Xu, Fan Ping, Wei Li, Qi Sun, Yuxiu Li
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway
    Yusong Ding, Haiyan Li, Yang Li, Dandan Liu, Liyuan Zhang, Tongling Wang, Tao Liu, Long Ma, Rocío De la Puerta
    Evidence-Based Complementary and Alternative Medicine.2020;[Epub]     CrossRef
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    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • Roles of Autophagy in Oxidative Stress
    Hyeong Rok Yun, Yong Hwa Jo, Jieun Kim, Yoonhwa Shin, Sung Soo Kim, Tae Gyu Choi
    International Journal of Molecular Sciences.2020; 21(9): 3289.     CrossRef
  • Antioxidant and prebiotic effects of a beverage composed by tropical fruits and yacon in alloxan-induced diabetic rats
    Ana Paula DIONISIO, Luciano Bruno de CARVALHO-SILVA, Nara Menezes VIEIRA, Nedio Jair WURLITZER, Ana Carolina da Silva PEREIRA, Maria de Fatima BORGES, Deborah dos Santos GARRUTI, Idila dos Santos ARAÚJO
    Food Science and Technology.2020; 40(1): 202.     CrossRef
  • Pro-oxidant–antioxidant balance (PAB) as a prognostic index in assessing the cardiovascular risk factors: A narrative review
    Hamideh Ghazizadeh, Maryam Saberi-Karimian, Maliheh Aghasizadeh, Reza Sahebi, Hamed Ghazavi, Hamed Khedmatgozar, Ameneh Timar, Mohadeseh Rohban, Ali Javandoost, Majid Ghayour-Mobarhan
    Obesity Medicine.2020; 19: 100272.     CrossRef
  • Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks
    Yixiao Shen, Jing Han, Xiaoyan Zheng, Binling Ai, Yang Yang, Dao Xiao, Lili Zheng, Zhanwu Sheng
    Applied Sciences.2020; 10(7): 2249.     CrossRef
  • Trigonella stellata reduced the deleterious effects of diabetes mellitus through alleviation of oxidative stress, antioxidant- and drug-metabolizing enzymes activities
    Salah A. Sheweita, Sara A. ElHady, Hala M. Hammoda
    Journal of Ethnopharmacology.2020; 256: 112821.     CrossRef
  • A Shift Toward a Plant-Centered Diet From Young to Middle Adulthood and Subsequent Risk of Type 2 Diabetes and Weight Gain: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Yuni Choi, Nicole Larson, Daniel D. Gallaher, Andrew O. Odegaard, Jamal S. Rana, James M. Shikany, Lyn M. Steffen, David R. Jacobs
    Diabetes Care.2020; 43(11): 2796.     CrossRef
  • Ascorbic acid supplementation in type 2 diabetes mellitus
    Lipeng Shi, Xuqin Du, Pei Guo, Lumei Huang, Peng Qi, Qianhui Gong
    Medicine.2020; 99(45): e23125.     CrossRef
  • Analysis of the Effect of Fish Bars Made of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour to Reduce Oxidative Stress in a Diabetic Rat Model
    Deni ELNOVRIZA, Hadi RIYADI, Rimbawan RIMBAWAN, Evy DAMAYANTHI, Adi WINARTO
    Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S36.     CrossRef
  • Antioxidant activity of crude ethanolic extract and fractions of Ziziphus mauritiana Lam. (Rhamnaceae) leaves from Burkina Faso
    Estelle N.H. Youl, Cyrille A.P. Ouédraogo, Moustapha Gambo, Moussa Ouédraogo, Martin Kiendrebéogo, Aristide Traoré, Innocent Pierre Guissou
    Journal of Basic and Clinical Physiology and Pharmacology.2019;[Epub]     CrossRef
  • CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation
    Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Free Radical Biology and Medicine.2019; 134: 505.     CrossRef
  • Comparative proteomic analysis reveals drug resistance of Staphylococcus xylosus ATCC700404 under tylosin stress
    Xin Liu, Jinpeng Wang, Mo Chen, Ruixiang Che, Wenya Ding, Fei Yu, Yonghui Zhou, Wenqiang Cui, Xing Xiaoxu, Bello-Onaghise God’spower, Yanhua Li
    BMC Veterinary Research.2019;[Epub]     CrossRef
  • The Potential of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour as a Zinc Source to Control Blood Glucose and Impact on Oxidative Stress in a Diabetic Rat Model
    Deni Elnovriza, Hadi Riyadi, Rimbawan ., Evy Damayanthi, Adi Winarto
    Pakistan Journal of Nutrition.2019; 18(3): 264.     CrossRef
  • Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
    Li Zuo, Evan R. Prather, Mykola Stetskiv, Davis E. Garrison, James R. Meade, Timotheus I. Peace, Tingyang Zhou
    International Journal of Molecular Sciences.2019; 20(18): 4472.     CrossRef
  • The variations of some salivary parameters as probable indices of the hereditary diabetes
    Menicagli Roberto, Marotta Ortensio
    International Journal of Preventive Medicine.2019; 10(1): 11.     CrossRef
  • The Interrelationship between Job Stress with the Immune System and Functional Memory of Women Working in Diagnostic Laboratories
    Mansoureh Sadeghi-Yarandi, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad, Neda Khaletbari
    The Neuroscience Journal of Shefaye Khatam.2019; 7(2): 23.     CrossRef
  • Effect of Cinnamon Administration on Fertility of Normal and Diabetic Male Rats
    Mahmoud Al-Shawabk, Abdulrahim Al Jamal
    Pakistan Journal of Nutrition.2019; 18(5): 491.     CrossRef
  • White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus
    Farhan Aslam, Sanaullah Iqbal, Muhammad Nasir, Aftab Ahmad Anjum
    Journal of the American College of Nutrition.2019; 38(3): 235.     CrossRef
  • Effect of combination of Gynura procumbens aqueous extract and Trigona spp. honey on fertility and libido of streptozotocin-induced hyperglycaemic male rats
    Khaidatul Akmar, MahanemMat Noor
    Asian Pacific Journal of Reproduction.2019; 8(2): 56.     CrossRef
  • Serum Antioxidant Parameters are Significantly Increased in Patients with Type 2 Diabetes Mellitus after Consumption of Chinese Propolis: A Randomized Controlled Trial Based on Fasting Serum Glucose Level
    Weina Gao, Lingling Pu, Jingyu Wei, Zhanxin Yao, Yawen Wang, Tala Shi, Liting Zhao, Changya Jiao, Changjiang Guo
    Diabetes Therapy.2018; 9(1): 101.     CrossRef
  • Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes
    Natália Nogueira do Nascimento Kaut, Ana Carolina Silveira Rabelo, Glaucy Rodrigues Araujo, Jason Guy Taylor, Marcelo Eustáquio Silva, Maria Lúcia Pedrosa, Miriam Martins Chaves, Joamyr Victor Rossoni Junior, Daniela Caldeira Costa, Laura De Martino
    Evidence-Based Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • The Potential of South African Herbal Tisanes, Rooibos and Honeybush in the Management of Type 2 Diabetes Mellitus
    Olawale R. Ajuwon, Ademola O. Ayeleso, Gbenga A. Adefolaju
    Molecules.2018; 23(12): 3207.     CrossRef
  • Clinical variables and ethnicity may influenced by polymorphism of CAT −262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications
    A. Eddaikra, H. Amroun, R. Raache, A. Galleze, N. Abdallah-Elhadj, M. Azzouz, F. Meçabih, B. Mechti, M.C. Abbadi, C. Touil-Boukoffa, N. Attal
    Gene.2018; 670: 182.     CrossRef
  • Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
    Astrid Borchert, Jacqueline Kalms, Sophia R. Roth, Marlena Rademacher, Andrea Schmidt, Hermann-Georg Holzhutter, Hartmut Kuhn, Patrick Scheerer
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2018; 1863(9): 1095.     CrossRef
  • The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
    Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • Mice pancreatic islets protection from oxidative stress induced by single-walled carbon nanotubes through naringin
    A Ahangarpour, S Alboghobeish, AA Oroojan, MA Dehghani
    Human & Experimental Toxicology.2018; 37(12): 1268.     CrossRef
  • Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity
    Biplab Giri, Sananda Dey, Tanaya Das, Mrinmoy Sarkar, Jhimli Banerjee, Sandeep Kumar Dash
    Biomedicine & Pharmacotherapy.2018; 107: 306.     CrossRef
  • Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists?
    Rodrigo B. Mansur, Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Roger S. McIntyre
    Neuropharmacology.2018; 136: 335.     CrossRef
  • The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways
    Khalil Ali Ahmad, Hong Ze, Jichao Chen, Farhan Ullah Khan, Chen Xuezhuo, Jinyi Xu, Ding Qilong
    Biomedicine & Pharmacotherapy.2018; 106: 1734.     CrossRef
  • Curcumin alleviates liver oxidative stress in type 1 diabetic rats
    Zhenglu Xie, Binbin Wu, Guozhi Shen, Xiaqing Li, Qianying Wu
    Molecular Medicine Reports.2017;[Epub]     CrossRef
  • Treatment with a GLP−1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders
    Rodrigo B. Mansur, Andre Zugman, Juhie Ahmed, Danielle S. Cha, Mehala Subramaniapillai, Yena Lee, Julie Lovshin, Jung G. Lee, Jae-Hon Lee, Vladislav Drobinin, Jason Newport, Elisa Brietzke, Eva Z. Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas
    European Neuropsychopharmacology.2017; 27(11): 1153.     CrossRef
  • Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell
    J. Wu, H. Wei, H. Qu, Z. Feng, J. Long, Q. Ge, H. Deng
    Journal of Endocrinological Investigation.2017; 40(11): 1219.     CrossRef
  • Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey
    Dan Quansah, Kyungho Ha, Shinyoung Jun, Seong-Ah Kim, Sangah Shin, Gyung-Ah Wie, Hyojee Joung
    Molecules.2017; 22(10): 1664.     CrossRef
  • Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats
    Zhenglu Xie, Xinqi Zeng, Xiaqing Li, Binbin Wu, Guozhi Shen, Qianying Wu, Changbiao Wu
    Open Life Sciences.2017; 12(1): 452.     CrossRef
  • Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset
    Cüneyt A. Aral, Özlem Nalbantoğlu, Bilge G. Nur, Mustafa Altunsoy, Kübra Aral
    Archives of Oral Biology.2017; 82: 115.     CrossRef
  • Evaluation and Application of a Novel Quantitative Antioxidant Activity Assay Based on Cellular Metabolomics
    Jianteng Wei, Qingping Hu, Ningli Wang, Yewei Liu, Dong Pei, Duolong Di
    Chromatographia.2017; 80(4): 617.     CrossRef
  • C-X-C motif chemokine ligand 8 promotes endothelial cell homing via the Akt-signal transducer and activator of transcription pathway to accelerate healing of ischemic and hypoxic skin ulcers
    Lei Shen, Peng Zhang, Shanqiang Zhang, Liping Xie, Lijie Yao, Weiya Lang, Jie Lian, Wei Qin, Meng Zhang, Liang Ji
    Experimental and Therapeutic Medicine.2017; 13(6): 3021.     CrossRef
  • STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper
    Rachel T Scarl, C Martin Lawrence, Hannah M Gordon, Craig S Nunemaker
    Journal of Endocrinology.2017; 234(3): R123.     CrossRef
  • Current views on neuropeptide Y and diabetes-related atherosclerosis
    Wei-wei Sun, Ping Zhu, Yan-chuan Shi, Chen-liang Zhang, Xu-feng Huang, Shi-yu Liang, Zhi-yuan Song, Shu Lin
    Diabetes and Vascular Disease Research.2017; 14(4): 277.     CrossRef
  • Teucrium polium extract reverses symptoms of streptozotocin-induced diabetes in rats via rebalancing the Pdx1 and FoxO1 expressions
    Parvaneh Sadat Tabatabaie, Razieh Yazdanparast
    Biomedicine & Pharmacotherapy.2017; 93: 1033.     CrossRef
  • Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells
    Pachamuthu Vanitha, Sankareswaran Senthilkumar, Sireesh Dornadula, Sundaramurthy Anandhakumar, Palanisamy Rajaguru, Kunka Mohanram Ramkumar
    European Journal of Pharmacology.2017; 801: 9.     CrossRef
  • Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir
    Jian Zhang, Xiao Zhao, Yunyun Jiang, Wen Zhao, Ting Guo, Yongqiang Cao, Junwei Teng, Xiaona Hao, Juan Zhao, Zhennai Yang
    Journal of Dairy Science.2017; 100(8): 6025.     CrossRef
  • Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
    Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
    Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
  • Differential dose-dependent Effects of Zinc Oxide Nanoparticles on Oxidative stress-mediated Pancreatic β-cell Death
    Swati C Asani, Rinku D Umrani, Kishore M Paknikar
    Nanomedicine.2017; 12(7): 745.     CrossRef
  • Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy
    Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
    International Journal of Molecular Sciences.2017; 18(3): 569.     CrossRef
  • Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells
    Suma Elumalai, Udayakumar Karunakaran, In Kyu Lee, Jun Sung Moon, Kyu Chang Won
    Redox Biology.2017; 11: 126.     CrossRef
  • Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin
    Samsulrizal Nurdiana, Yong Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal’ain Azmi, Noor Syaffinaz Noor Mohamad Zin, Mahdi Ebrahimi
    BMC Complementary and Alternative Medicine.2017;[Epub]     CrossRef
  • Murraya paniculata(L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats
    Cicero Diego Almino Menezes, Francisca Adilfa de Oliveira Garcia, Glauce Socorro de Barros Viana, Patricia Gonçalves Pinheiro, Cícero Francisco Bezerra Felipe, Thaís Rodrigues de Albuquerque, Alisson Cordeiro Moreira, Enaide Soares Santos, Maynara Rodrigu
    Phytotherapy Research.2017; 31(11): 1747.     CrossRef
  • Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review
    K. K. Asanka Sanjeewa, Won Woo Lee, Jae-Il Kim, You-Jin Jeon
    Journal of Applied Phycology.2017; 29(6): 3109.     CrossRef
  • The thioredoxin and glutathione-dependent H2O2 consumption pathways in muscle mitochondria: Involvement in H2O2 metabolism and consequence to H2O2 efflux assays
    Daniel Munro, Sheena Banh, Emianka Sotiri, Nahid Tamanna, Jason R. Treberg
    Free Radical Biology and Medicine.2016; 96: 334.     CrossRef
  • Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial
    I. Nikbakht-Jam, M. Khademi, M. Nosrati, S. Eslami, M. Foroutan-Tanha, A. Sahebkar, S. Tavalaie, M. Ghayour-Mobarhan, G.A.A. Ferns, F. Hadizadeh, S.A.S. Tabassi, S.A. Mohajeri, M. Emamian
    European Journal of Integrative Medicine.2016; 8(3): 307.     CrossRef
  • Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line
    Armin Mooranian, Rebecca Negrulj, Frank Arfuso, Hani Al-Salami
    Artificial Cells, Nanomedicine, and Biotechnology.2016; 44(7): 1642.     CrossRef
  • Lipid peroxidation is associated with poor control of type-2 diabetes mellitus
    Sameer Hassan Fatani, Abdullatif Taha Babakr, EssamEldin Mohamed NourEldin, Abdalla A. Almarzouki
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(2): S64.     CrossRef
  • Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer’s disease Mouse Brain
    Du Fang, Zhihua Zhang, Hang Li, Qing Yu, Justin T. Douglas, Anna Bratasz, Periannan Kuppusamy, Shirley ShiDu Yan, Hemachandra Reddy
    Journal of Alzheimer's Disease.2016; 51(2): 571.     CrossRef
  • Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic INS-1E beta cells
    Beatriz Fernandez-Gomez, Sonia Ramos, Luis Goya, María Dolores Mesa, María Dolores del Castillo, María Ángeles Martín
    Food Research International.2016; 89: 1015.     CrossRef
  • Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene
    Simone Hanna Brütsch, Marlena Rademacher, Sophia Regina Roth, Karin Müller, Susanne Eder, Dagmar Viertel, Christiane Franz, Hartmut Kuhn, Astrid Borchert
    Journal of Biological Chemistry.2016; 291(45): 23578.     CrossRef
  • Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5
    C.S. Moura, P.C.B. Lollo, P.N. Morato, E.A. Esmerino, L.P. Margalho, V.A. Santos-Junior, P.T. Coimbra, L.P. Cappato, M.C. Silva, A.S. Garcia-Gomes, D. Granato, H.M. A. Bolini, A.S. Sant'Ana, A.G. Cruz, Jaime Amaya-Farfan
    Food Research International.2016; 90: 275.     CrossRef
  • Discovery of biomarkers for oxidative stress based on cellular metabolomics
    Ningli Wang, Jianteng Wei, Yewei Liu, Dong Pei, Qingping Hu, Yu Wang, Duolong Di
    Biomarkers.2016; 21(5): 449.     CrossRef
  • Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study
    Wilson KC Leung, L Gao, Parco M Siu, Christopher WK Lai
    Life Sciences.2016; 166: 121.     CrossRef
  • Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus
    Liting Zhao, Lingling Pu, Jingyu Wei, Jinghua Li, Jianquan Wu, Zhonghao Xin, Weina Gao, Changjiang Guo
    International Journal of Environmental Research and Public Health.2016; 13(5): 498.     CrossRef
  • Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
    Stephen F. Vatner, Ronald E. Pachon, Dorothy E. Vatner
    Oxidative Medicine and Cellular Longevity.2015; 2015: 1.     CrossRef
  • Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species
    Bruno Silva, Ana Seca, Maria Barreto, Diana Pinto
    International Journal of Molecular Sciences.2015; 16(8): 17160.     CrossRef
  • Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells
    Nathalie Auberval, Stéphanie Dal, William Bietiger, Elodie Seyfritz, Jean Peluso, Christian Muller, Minjie Zhao, Eric Marchioni, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Valérie Schini-Kerth, Séverine Sigrist
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells
    Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(11): 2414.     CrossRef
  • Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health
    James P. Kehrer, Lars-Oliver Klotz
    Critical Reviews in Toxicology.2015; 45(9): 765.     CrossRef
  • Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of theAlox15Gene Does Not Rescue Such Knock-In Mice
    Simone Hanna Brütsch, Chi Chiu Wang, Lu Li, Hannelore Stender, Nilgün Neziroglu, Constanze Richter, Hartmut Kuhn, Astrid Borchert
    Antioxidants & Redox Signaling.2015; 22(4): 281.     CrossRef
  • Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids
    Justyna Janikiewicz, Katarzyna Hanzelka, Kamil Kozinski, Katarzyna Kolczynska, Agnieszka Dobrzyn
    Biochemical and Biophysical Research Communications.2015; 460(3): 491.     CrossRef
  • Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals
    C. Mozzini, U. Garbin, C. Stranieri, A. Pasini, E. Solani, I. A. Tinelli, L. Cominacini, A.M. Fratta Pasini
    Free Radical Research.2015; 49(3): 244.     CrossRef
  • El estrés oxidativo como predictor de longevidad; estudio de casos y controles
    Ángel Belenguer Varea, Kheira Mohamed Abdelaziz, Juan Antonio Avellana Zaragoza, Consuelo Borrás Blasco, Paula Sanchis Aguilar, José Viña Ribes
    Revista Española de Geriatría y Gerontología.2015; 50(1): 16.     CrossRef
  • Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways
    Elisa Fernández-Millán, Sonia Ramos, Carmen Alvarez, Laura Bravo, Luis Goya, María Ángeles Martín
    Food and Chemical Toxicology.2014; 66: 245.     CrossRef
  • Decreased serum CA19‐9 is associated with improvement of insulin resistance and metabolic control in patients with obesity and type 2 diabetes after Roux‐en‐Y gastric bypass
    Yinfang Tu, Haoyong Yu, Pin Zhang, Jianzhong Di, Xiaodong Han, Songhua Wu, Yuqian Bao, Weiping Jia
    Journal of Diabetes Investigation.2014; 5(6): 694.     CrossRef
  • Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach
    Gemma Flores-Mateo, Roberto Elosua, Teresa Rodriguez-Blanco, Josep Basora-Gallisà, Mònica Bulló, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Ramon Estruch, Dolores Corella, Montserrat Fitó, Miquel Fiol, Fernando Arós, Enrique Gómez-Gracia, Isaac
    PLoS ONE.2014; 9(9): e105881.     CrossRef
  • Inflamed moods: A review of the interactions between inflammation and mood disorders
    Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur, Roger S. McIntyre
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 53: 23.     CrossRef
  • Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes
    Soo Lim, Jae Hyun Bae, Eun Ju Chun, Haeryoung Kim, So Yeon Kim, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Jose C. Florez, Hak Chul Jang
    Acta Diabetologica.2014; 51(5): 739.     CrossRef
  • Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics
    Sylwia Dzięgielewska-Gęsiak, Ewa Wysocka, Sławomir Michalak, Ewa Nowakowska-Zajdel, Teresa Kokot, Małgorzata Muc-Wierzgoń
    Oxidative Medicine and Cellular Longevity.2014; 2014: 1.     CrossRef
  • Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus
    Hong Hanh Thi Tran, Minh Chau Nguyen, Hoang Tram Le, Thi Luyen Nguyen, Thanh Binh Pham, Van Minh Chau, Hoai Nam Nguyen, Tien Dat Nguyen
    Pharmaceutical Biology.2014; 52(1): 74.     CrossRef
  • Diabetes Mellitus and Disturbances in Brain Connectivity: A Bidirectional Relationship?
    Rodrigo B. Mansur, Danielle S. Cha, Hanna O. Woldeyohannes, Joanna K. Soczynska, Andre Zugman, Elisa Brietzke, Roger S. McIntyre
    NeuroMolecular Medicine.2014; 16(4): 658.     CrossRef
  • Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
    Liang-Jun Yan
    Journal of Diabetes Research.2014; 2014: 1.     CrossRef
  • Vitamin C Protects against INS832/13 ^|^beta;-Cell Death and/or Dysfunction Caused by Glucolipotoxicity or 3T3-L1 Adipocyte Coculture
    Ruojun WANG, Jia LIU, Xiaoxuan GUO, Fengyi GAO, Baoping JI, Feng ZHOU
    Journal of Nutritional Science and Vitaminology.2014; 60(5): 313.     CrossRef
  • Antioxidant activities of novel small-molecule polysaccharide fractions purified from Portulaca oleracea L.
    Yu-Ping Li, Li-Hua Yao, Guan-Jie Wu, Xiao-Fang Pi, Yan-Chun Gong, Ruo-Shong Ye, Chen-Xi Wang
    Food Science and Biotechnology.2014; 23(6): 2045.     CrossRef
  • Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice
    Michela Novelli, Donatella Canistro, Manuela Martano, Niccola Funel, Andrea Sapone, Simone Melega, Matilde Masini, Vincenzo De Tata, Anna Pippa, Cecilia Vecoli, Daniela Campani, Rocco De Siena, Antonio Soleti, Moreno Paolini, Pellegrino Masiello
    European Journal of Pharmacology.2014; 729: 37.     CrossRef
  • Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1
    Yong Son, Ju Hwan Lee, Hun-Taeg Chung, Hyun-Ock Pae
    Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
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    Jordan Wright, Julia Birk, Leena Haataja, Ming Liu, Thomas Ramming, Michael A. Weiss, Christian Appenzeller-Herzog, Peter Arvan
    Journal of Biological Chemistry.2013; 288(43): 31010.     CrossRef
  • Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose
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    Current Diabetes Reports.2013; 13(6): 768.     CrossRef
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Seok Man Son
Diabetes Metab J. 2012;36(3):190-198.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.190
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AbstractAbstract PDFPubReader   

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

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  • Association between composite dietary antioxidant index and stroke among individuals with diabetes
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    World Journal of Diabetes.2024; 15(8): 1742.     CrossRef
  • In Vitro and in-silico Anti-diabetic Evaluation of the Combination of Annona squamosa Linn., Leaf Extract and Oleanolic Acid
    Sasmita Dash, Nityananda Sahoo, Gurudutta Pattnaik, Chandan Das, Sovan Pattanaik, Goutam Ghosh, Goutam Rath, Biswakanth Kar
    Current Bioactive Compounds.2024;[Epub]     CrossRef
  • The Relationship Between Lycopene and Metabolic Diseases
    Anna Kulawik, Judyta Cielecka-Piontek, Bogusław Czerny, Adam Kamiński, Przemysław Zalewski
    Nutrients.2024; 16(21): 3708.     CrossRef
  • The Potential of Neuregulin 4 as a Novel Biomarker and Therapeutic Agent for Vascular Complications in Type 2 Diabetes Mellitus
    Xiaofang Dan, Ke Li, Jiali Xu, Pijun Yan
    Journal of Inflammation Research.2024; Volume 17: 8543.     CrossRef
  • High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
    Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
    Life Sciences.2023; 312: 121208.     CrossRef
  • Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
    Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
    Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
    Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
    Aquaculture Research.2023; 2023: 1.     CrossRef
  • Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
    Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
    Cells.2023; 12(4): 583.     CrossRef
  • In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
    Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
    Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
  • Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
    Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
    Biochimie.2022; 195: 114.     CrossRef
  • Effects of Smoking on Diabetic Nephropathy
    Yasemin Gündoğdu, İnan Anaforoğlu
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
    Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
    Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
    Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
  • Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
    Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
    Aquatic Toxicology.2022; 250: 106259.     CrossRef
  • “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
    Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
  • Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
    Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
    Molecules.2022; 27(22): 8043.     CrossRef
  • p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
    Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
    Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
  • Elucidation of phytochemicals and antioxidants properties ofSasa quelpaertensis
    Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
    International Journal of Food Properties.2021; 24(1): 210.     CrossRef
  • Organelle dynamics of endothelial mitochondria in diabetic angiopathy
    Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
    European Journal of Pharmacology.2021; 895: 173865.     CrossRef
  • Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
    Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
    Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
    Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
  • NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
    Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
    Cells.2021; 10(2): 314.     CrossRef
  • Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
    Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
    Sweta Pal, G. Nageswar Rao, Arttatrana Pal
    Life Sciences.2021; 279: 119693.     CrossRef
  • The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
    Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
    Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
  • The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
    V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
    Cytology and Genetics.2021; 55(4): 331.     CrossRef
  • Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
    Hollie Speer, Andrew J. McKune
    Antioxidants.2021; 10(8): 1247.     CrossRef
  • Natural Antioxidants in New Age-Related Diseases
    Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
    Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
  • Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
    Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
    Obesity Medicine.2020; 19: 100274.     CrossRef
  • Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
    Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
    Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
  • Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
    Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
    Industrial Crops and Products.2020; 146: 112158.     CrossRef
  • Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
    Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Heme on Pulmonary Malaria: Friend or Foe?
    Tatiana Almeida Pádua, Mariana Conceição Souza
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
    Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
    Experimental Eye Research.2020; 201: 108255.     CrossRef
  • The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
    Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
    Nutrients.2020; 12(7): 2108.     CrossRef
  • Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
    Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
    Antioxidants.2020; 9(6): 491.     CrossRef
  • Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
    Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
  • Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
    M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
    Surfaces and Interfaces.2020; 19: 100540.     CrossRef
  • The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
    Sheetal Panday, Raghav Talreja, Mahendra Kavdia
    Microvascular Research.2020; 131: 104010.     CrossRef
  • Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
    V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
    Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
  • Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
    Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
    Frontiers in Veterinary Science.2020;[Epub]     CrossRef
  • Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
    Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
  • Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
    J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
    Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
  • Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
    Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • The impact of xanthine oxidase (XO) on hemolytic diseases
    Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
    Redox Biology.2019; 21: 101072.     CrossRef
  • What is responsible for antioxidant properties of polyphenolic compounds from plants?
    Małgorzata Olszowy
    Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
  • Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
    Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
    Cells.2019; 8(5): 464.     CrossRef
  • Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
    Xiaojuan Yang, Jing Song, Liang-Jun Yan
    Antioxidants.2019; 8(2): 32.     CrossRef
  • Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
    Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
    Current Eye Research.2019; 44(3): 294.     CrossRef
  • Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
    Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Novel Curcumin C66 That Protects Diabetes‐Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
    Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang, Ayman M. Mahmoud
    Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
  • Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
    Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
    Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
  • Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
    Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
    Reproductive Sciences.2018; 25(11): 1531.     CrossRef
  • Nutrients and Oxidative Stress: Friend or Foe?
    Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew, Rodrigo Valenzuela
    Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
  • Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
    Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • An Update on Hypertension in Children With Type 1 Diabetes
    Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
    Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
  • Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
    Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
    Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
    Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
  • Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
    Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
    Food Research International.2017; 95: 117.     CrossRef
  • Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
    Veerappan Ramanathan, Malarvili Thekkumala
    Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
  • Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
    Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
    Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
  • Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
    Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
    BioImpacts.2017; 7(4): 219.     CrossRef
  • The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
    Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
    The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
  • Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
    Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
    Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
    Aging and disease.2016; 7(1): 90.     CrossRef
  • İNSAN VE HAYVANLARDA DİABETES MELLİTUS
    Özlem ÖZMEN, Senay TOPSAKAL
    Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
  • The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
    Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
    Pharmacological Research.2016; 113: 186.     CrossRef
  • Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
    Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
    Food Chemistry.2016; 201: 315.     CrossRef
  • Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
    Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
    Endocrine.2015; 50(2): 405.     CrossRef
  • Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
    Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
    International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
  • Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
    L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
    British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
  • Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
    Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
    Pathophysiology.2015; 22(4): 189.     CrossRef
  • Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
    J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
    Oral Diseases.2015; 21(5): 634.     CrossRef
  • Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
    Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
    PLOS ONE.2015; 10(4): e0123987.     CrossRef
  • Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
    Abeer Hanafy, Jihan M. Badr
    Natural Product Research.2014; 28(24): 2351.     CrossRef
  • Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
    TM Boĭchuk, TP Savchuk
    Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
  • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    Paulo Zoé Costa, Raquel Soares
    Life Sciences.2013; 92(22): 1037.     CrossRef
  • Oxidative-stress-induced epigenetic changes in chronic diabetic complications
    Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
    Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
  • Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
    Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
    Archives of Medical Research.2013; 44(7): 514.     CrossRef
  • Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
    Daye Cheng, Bin Liang, Yunhui Li
    BioMed Research International.2013; 2013: 1.     CrossRef
Original Articles
Glucose Oxidation and Production of Reactive Oxygen Species (ROS) in INS-1 Cells and Rat Islet Cells Exposed to High Glucose.
Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Korean Diabetes J. 2006;30(4):246-253.   Published online July 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.4.246
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AbstractAbstract PDF
BACKGROUND
Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes beta cell dysfunction that is a process known as glucose toxicity. It has been reported that hyperglycemia increases the production of reactive oxygen species (ROS) in human islets and that ROS accumulation causes beta cell dysfunction associated with low capacity of intrinsic antioxidant enzymes. Also it has been postulated that this increase in ROS is prevented by an inhibitor of electron transport chain complex. The purpose of this study were to determine whether prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations disrupts the intracellular balance between ROS thereby causing defective insulin secretion and to evaluate the site of hyperglycemia-induced ROS production. METHODS: INS-1 cells & rat islets were incubated in increasing concentrations of glucose and either an inhibitor of complex I & II (TTFA), an uncoupler of oxidative phosphorylation (CCCP), aCCA, etc and also incubated in increasing concentration of glyceraldehyde and N-acetylcystein. Then intracellular peroxide levels by flow cytometric analysis and glucose induced insulin secretion were detected. RESULTS: We observed that incubation with 30 mM glucose increased intracellular peroxide levels but decreased glucose-stimulated insulin secretion (GSIS) (P < 0.05). Exposure to TTFA, CCCP, aCCA did not reduce this increased intracellular peroxide levels, and did not increase GSIS (P < 0.05). 24-h incubation with glyceraldehyde at 5.6 mM glucose increased intracellular peroxide levels and decreased insulin content. CONCLUSION: These observations indicate that there might be other origins in which ROS species are produced besides electron transport chain in mitochondria and glyceraldehyde may be a key molecule to produce ROS, and induce beta cell dysfunction.

Citations

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  • Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review
    Abdur Rauf, Anees Ahmed Khalil, Samir Awadallah, Shahid Ali Khan, Tareq Abu‐Izneid, Muhammad Kamran, Hassan A. Hemeg, Mohammad S. Mubarak, Ahood Khalid, Polrat Wilairatana
    Food Science & Nutrition.2024; 12(2): 675.     CrossRef
  • The Protective Effects of Chrysanthemum cornarium L. var. spatiosum Extract on HIT-T15 Pancreatic β-Cells against Alloxan-induced Oxidative Stress
    In-Hye Kim, Kang-Jin Cho, Jeong-Sook Ko, Jae-Hyun Kim, Ae-Son Om
    The Korean Journal of Food And Nutrition.2012; 25(1): 123.     CrossRef
Oxidative Stress of INS-1 Cell, HIT-T15 Cell and Rat Islet Cell as a Mechanism of Glucose Toxicity.
Mi Jung Eun, Kyu Chang Won, Jun Sung Moon, Sun Jung Mun, Ji Eun Lee, Ji Sung Yoon, Kyung Ah Chun, Ihn Ho Cho, Hyoung Woo Lee
Korean Diabetes J. 2005;29(5):393-400.   Published online September 1, 2005
  • 1,407 View
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AbstractAbstract PDF
BACKGOUND: Chronic hyperglycemia is the proximate cause of many complications of diabetes. The beta cells in type 2 diabetes are also adversely affected by chronic hyperglycemia, with this relentless deterioration in cell function, due to constant exposure to supraphysiologic concentrations of glucose, is termed glucose toxicity; however, the mechanism of glucose toxicity is uncertain. The purpose of this study was to determine whether prolonged exposure of pancreatic islets to supraphysiologic glucose concentration disrupts the intracellular balance between reactive oxygen species(ROS) and antioxidant enzyme; thereby, causing defective insulin secretion. METHODS: HIT-T15 cells were treated with H2O2(20, 50 and 100micrometer) directly added to the culture media, and then intracellular peroxide and insulin mRNA were then measured. The effects of H2O2 on the total peroxide level and insulin secretion were also examined. Isolated pancreatic islet cells from Wistar and 2 beta cell lines (INS-1, HIT-T15) were cultured in either a glucose or ribose (5.6, 11.1, 22.2, 30 and 50mM) containing culture media for 72hours. The intracellular peroxide was measured using flow cytometry and glucose stimulated insulin secretion(GSIS). RESULTS: The intracellular peroxide levels due to H2O2 in HIT-T15 cells were higher with a high concentration of H2O2, and the insulin mRNA in HIT-T15 cells decreased when the cells are treated with a high concentration H2O2. The insulin mRNA of the HIT-T15 cells cultured in a high concentration of ribose was lower than of those cultured in a low concentration of glucose. INS-1, HIT-T15 and rat islet cells, cultured for 72 hours, had progressively greater peroxide levels with higher concentrations of both glucose and ribose. The GSIS in the cells cultured in high concentrations of both glucose and ribose were decreased. CONCLUSION: These results suggest only one potential central mechanism for glucose toxicity in beta cells, this being the formation of excess ROS.
Review
Disturbed Shear Stress Induces Inflammation and Atherosclerosis-Role of BMP4 as a Mechanosensitive and Inflammatory Cytokine.
Hanjoong Jo, Hannah Song
Korean Diabetes J. 2005;29(4):271-281.   Published online July 1, 2005
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Atherosclerosis is an inflammatory disease occurring preferentially in arterial regions exposed to disturbed flow conditions including oscillatory shear stress(OS). In contrast, the arterial regions exposed to laminar shear(LS) are relatively lesion-free. The opposite effects of LS(atheroprotective) and OS(atherogenic) are likely to be determined by differential expression of genes and proteins. Therefore, numerous investigators including us carried out transcript profiling studies to identify mechanosensitive genes that are turned on or off in response to different shear conditions. Through this and subsequent verification approaches using both cultured endothelial cells and human coronary arteries containing atherosclerotic lesions, we discovered that BMP4 expression is a highly regulated by different shear conditions. More importantly, we discovered a novel role of BMP4 as a mechanosensitive pro-inflammatory cytokine. Exposing endothelial cells to OS increased BMP4 protein expression while LS decreased it. Also, we found BMP4 expression only in the selective patches of endothelial cells overlying foam cell lesions in human coronary arteries. Chronic exposure of endothelial cells to OS stimulates inflammatory responses in endothelial cells such as production of intercellular adhesion molecule 1(ICAM-1) leading to monocyte adhesion to endothelium. A series of studies have revealed that exposure to OS induces inflammatory responses by producing BMP4 in endothelial cells. BMP4 then stimulates ICAM-1 expression and monocyte adhesion by the reactive oxygen species(ROS) and NF kappa B-dependent mechanisms. ROS produced in response to OS and BMP4 are derived from NADPH oxidase involving nox1 and p47phox components. These findings strongly suggest that BMP4 is a mechanosensitive, inflammatory factor playing a critical role in early steps of atherogenesis in atheroprone areas. This review is written to summarize this emerging field of shear stress, inflammation and atherosclerosis.

Diabetes Metab J : Diabetes & Metabolism Journal
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