Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "RSPO1 protein, human"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
Others
Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance
Yea Eun Kang, Ji Min Kim, Hyon-Seung Yi, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2019;43(3):368-376.   Published online October 23, 2018
DOI: https://doi.org/10.4093/dmj.2018.0066
  • 4,941 View
  • 75 Download
  • 6 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   
Background

Recent in vivo studies indicated that R-spondin 1 (RSPO1) regulates food intake and increases insulin secretion, but its role in humans remains unknown. This study investigated the association between serum levels of RSPO1 and diverse metabolic parameters in humans.

Methods

The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed.

Results

Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects.

Conclusion

This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown.

Citations

Citations to this article as recorded by  
  • LGR4: A New Receptor Member in Endocrine and Metabolic Diseases
    Ningning Zhang, Mingyang Yuan, Jiqiu Wang
    Endocrine Reviews.2023; 44(4): 647.     CrossRef
  • R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters
    Tuğba GÜRBÜZ, Oya GÖKMEN, Asena AYAR MADENLİ, Berna DİLBAZ
    Journal of Health Sciences and Medicine.2023; 6(2): 449.     CrossRef
  • An early prediction model for type 2 diabetes mellitus based on genetic variants and nongenetic risk factors in a Han Chinese cohort
    Jinjin Li, Qun Ye, Hongxiao Jiao, Wanyao Wang, Kai Zhang, Chen Chen, Yuan Zhang, Shuzhi Feng, Ximo Wang, Yubao Chen, Huailin Gao, Fengjiang Wei, Wei-Dong Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/β-Catenin Signaling
    Lichao Hu, Mengyuan Ding, Weichun He
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Does Serum R-Spondin-1 Play a Role in PCOS Pathophysiology?
    Osman BAŞPINAR, Yasin ŞİMŞEK, Derya KOÇER, Oğuzhan Sıtkı DİZDAR, Hatice KAYIŞ TOPALOĞLU
    Genel Tıp Dergisi.2022; 32(5): 490.     CrossRef
  • Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway
    Xuesong Su, Guangyu Zhou, Mi Tian, Si Wu, Yanqiu Wang
    Experimental Cell Research.2021; 405(2): 112713.     CrossRef
  • Exosome miR‐27a‐3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma
    Xuehan Fan, Jingya Wang, Tingting Qin, Yujia Zhang, Wenting Liu, Kaiting Jiang, Dingzhi Huang
    Thoracic Cancer.2020; 11(6): 1453.     CrossRef
  • Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance
    Manoj Kumar Pujar, Basavaraj Vastrad, Chanabasayya Vastrad
    Biomolecules.2019; 9(2): 37.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal