Diabetes & Metabolism Journal

Brief Report

Genetics
Clinical Characteristics of Diabetes in People with Mitochondrial DNA 3243A>G Mutation in Korea: Eun Hoo Rho, Sang Ik Baek, Heerah Lee, Moon-Woo Seong, Jong-Hee Chae, Kyong Soo Park, Soo Heon Kwak; Diabetes Metab J. 2024;48(3):482-486. Published online February 1, 2024; DOI: https://doi.org/10.4093/dmj.2023.0078

1,654 View
238 Download
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Maternally inherited diabetes and deafness (MIDD) is a rare mitochondrial disorder primarily resulting from m.3243A>G mutation. The clinical characteristics of MIDD exhibit significant heterogeneity. Our study aims to delineate these characteristics and determine the potential correlation with m.3243A>G heteroplasmy levels. This retrospective, descriptive study encompassed patients with confirmed m.3243A>G mutation and diabetes mellitus at Seoul National University Hospital. Our cohort comprises 40 patients with MIDD, with a mean age at study enrollment of 33.3±12.9 years and an average % of heteroplasmy of 30.0%± 14.6% in the peripheral blood. The most prevalent comorbidity was hearing loss (90%), followed by albuminuria (61%), seizure (38%), and stroke (33%). We observed a significant negative correlation between % of heteroplasmy and age at diabetes diagnosis. These clinical features can aid in the suspicion of MIDD and further consideration of genetic testing for m.3243A>G mutation.

Citations

Citations to this article as recorded by

Clinical Characteristics of Diabetes in People with Mitochondrial DNA 3243A>G Mutation in Korea (Diabetes Metab J 2024;48:482-6)
Eun Hoo Rho, Soo Heon Kwak
Diabetes & Metabolism Journal.2024; 48(4): 818. CrossRef
MIDD Patients Should Not Be Confused with MELAS Patients, Even Though Both Carry the m.3243A>G Variant
Josef Finsterer, Sounira Mehri
Diabetes & Metabolism Journal.2024; 48(4): 816. CrossRef

Review

Pathophysiology
Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance: Yajie Fan, Zhipeng Yan, Tingting Li, Aolin Li, Xinbiao Fan, Zhongwen Qi, Junping Zhang; Diabetes Metab J. 2024;48(1):19-36. Published online January 3, 2024; DOI: https://doi.org/10.4093/dmj.2023.0110

5,159 View
248 Download
4 Web of Science
4 Crossref

Abstract PDF PubReader ePub

Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.

Citations

Citations to this article as recorded by

Association between METS-IR and heart failure: a cross-sectional study
Xiaozhou Su, Chunli Zhao, Xianwei Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Insulin–Heart Axis: Bridging Physiology to Insulin Resistance
Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Celestino Sardu, Luca Rinaldi, Vincenzo Russo, Marcellino Monda, Raffaele Marfella, Ferdinando Carlo Sasso
International Journal of Molecular Sciences.2024; 25(15): 8369. CrossRef
The web of intrigue: unraveling the role of NETosis within the gut-microbiome-immune-heart axis in acute myocardial infarction and heart failure
Tai Yasuda, Kate Deans, Aditi Shankar, Robert Chilton
Cardiovascular Endocrinology & Metabolism.2024;[Epub] CrossRef
Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance
Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Rocío Llamas-Ramos, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ruth Martí-Lluch, María Cortés Rodríguez, Inés Llamas-Ramos, Manuel A. Gómez-Marcos
Nutrients.2024; 16(18): 3106. CrossRef

Original Articles

Basic Research
DWN12088, A Prolyl-tRNA Synthetase Inhibitor, Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis: Dong-Keon Lee, Su Ho Jo, Eun Soo Lee, Kyung Bong Ha, Na Won Park, Deok-Hoon Kong, Sang-In Park, Joon Seok Park, Choon Hee Chung; Diabetes Metab J. 2024;48(1):97-111. Published online January 3, 2024; DOI: https://doi.org/10.4093/dmj.2022.0367

3,166 View
230 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Nonalcoholic steatohepatitis (NASH) is a liver disease caused by obesity that leads to hepatic lipoapoptosis, resulting in fibrosis and cirrhosis. However, the mechanism underlying NASH is largely unknown, and there is currently no effective therapeutic agent against it. DWN12088, an agent used for treating idiopathic pulmonary fibrosis, is a selective prolyl-tRNA synthetase (PRS) inhibitor that suppresses the synthesis of collagen. However, the mechanism underlying the hepatoprotective effect of DWN12088 is not clear. Therefore, we investigated the role of DWN12088 in NASH progression.
Methods
Mice were fed a chow diet or methionine-choline deficient (MCD)-diet, which was administered with DWN12088 or saline by oral gavage for 6 weeks. The effects of DWN12088 on NASH were evaluated by pathophysiological examinations, such as real-time quantitative reverse transcription polymerase chain reaction, immunoblotting, biochemical analysis, and immunohistochemistry. Molecular and cellular mechanisms of hepatic injury were assessed by in vitro cell culture.
Results
DWN12088 attenuated palmitic acid (PA)-induced lipid accumulation and lipoapoptosis by downregulating the Rho-kinase (ROCK)/AMP-activated protein kinase (AMPK)/sterol regulatory element-binding protein-1c (SREBP-1c) and protein kinase R-like endoplasmic reticulum kinase (PERK)/α subunit of eukaryotic initiation factor 2 (eIF2α)/activating transcription factor 4 (ATF4)/C/EBP-homologous protein (CHOP) signaling cascades. PA increased but DWN12088 inhibited the phosphorylation of nuclear factor-κB (NF-κB) p65 (Ser536, Ser276) and the expression of proinflammatory genes. Moreover, the DWN12088 inhibited transforming growth factor β (TGFβ)-induced pro-fibrotic gene expression by suppressing TGFβ receptor 1 (TGFβR1)/Smad2/3 and TGFβR1/glutamyl-prolyl-tRNA synthetase (EPRS)/signal transducer and activator of transcription 6 (STAT6) axis signaling. In the case of MCD-diet-induced NASH, DWN12088 reduced hepatic steatosis, inflammation, and lipoapoptosis and prevented the progression of fibrosis.
Conclusion
Our findings provide new insights about DWN12088, namely that it plays an important role in the overall improvement of NASH. Hence, DWN12088 shows great potential to be developed as a new integrated therapeutic agent for NASH.

Drug/Regimen
Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial: Nikolai N. Scherbak, Robert Kruse, Thomas Nyström, Johan Jendle; Diabetes Metab J. 2023;47(5):668-681. Published online June 22, 2023; DOI: https://doi.org/10.4093/dmj.2022.0342

3,424 View
152 Download
2 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Diabetes is a chronic disease with several long-term complications. Several glucose-lowering drugs are used to treat type 2 diabetes mellitus (T2DM), e.g., glimepiride and liraglutide, in which both having different modes of action. Circulating microRNAs (miRNAs) are suggested as potential biomarkers that are associated with the disease development and the effects of the treatment. In the current study we evaluated the effect of glimepiride, liraglutide on the expression of the circulating miRNAs.
Methods
The present study is a post hoc trial from a previously randomized control trial comparing liraglutide versus glimepiride both in combination with metformin in subjects with T2DM, and subclinical heart failure. miRNAs were determined in the subjects’ serum samples with next generation sequencing. Expression patterns of the circulating miRNAs were analyzed using bioinformatic univariate and multivariate analyses (clinical trial registration: NCT01425580).
Results
Univariate analyses show that treatment with glimepiride altered expression of three miRNAs in patient serum, miR-206, miR-182-5p, and miR-766-3p. Both miR-182-5p and miR-766-3p were also picked up among the top contributing miRNAs with penalized regularised logistic regressions (Lasso). The highest-ranked miRNAs with respect to Lasso coefficients were miR-3960, miR-31-5p, miR-3613-3p, and miR-378a-3p. Liraglutide treatment did not significantly influence levels of circulating miRNAs.
Conclusion
Present study indicates that glucose-lowering drugs differently affect the expression of circulating miRNAs in serum in individuals with T2DM. More studies are required to investigate possible mechanisms by which glimepiride is affecting the expression of circulating miRNAs.

Citations

Citations to this article as recorded by

Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2023;47:668-81)
Nikolai N. Scherbak, Robert Kruse, Thomas Nyström, Johan Jendle
Diabetes & Metabolism Journal.2023; 47(6): 882. CrossRef
Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2023;47:668-81)
Da Young Lee
Diabetes & Metabolism Journal.2023; 47(6): 879. CrossRef

Others
Change Profiles and Functional Targets of MicroRNAs in Type 2 Diabetes Mellitus Patients with Obesity: Guanhua Lu, Huanhuan Gao, Zhiyong Dong, Shuwen Jiang, Ruixiang Hu, Cunchuan Wang; Diabetes Metab J. 2023;47(4):559-570. Published online April 25, 2023; DOI: https://doi.org/10.4093/dmj.2022.0226

2,517 View
95 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
MicroRNAs (miRNAs) exert an essential contribution to obesity and type 2 diabetes mellitus (T2DM). This study aimed to investigate the differences of miRNAs in the presence and absence of T2DM in patients with obesity, as well as before and after bariatric surgery in T2DM patients with obesity. Characterization of the common changes in both was further analyzed.
Methods
We enrolled 15 patients with obesity but without T2DM and 15 patients with both obesity and T2DM. Their preoperative clinical data and serum samples were collected, as well as 1 month after bariatric surgery. The serum samples were analyzed by miRNA sequencing, and the miRNAs profiles and target genes characteristics were compared.
Results
Patients with T2DM had 16 up-regulated and 32 down-regulated miRNAs compared to patients without T2DM. Improvement in metabolic metrics after bariatric surgery of T2DM patients with obesity was correlated with changes in miRNAs, as evidenced by the upregulation of 20 miRNAs and the downregulation of 30 miRNAs. Analysis of the two miRNAs profiles identified seven intersecting miRNAs that showed opposite changes. The target genes of these seven miRNAs were substantially enriched in terms or pathways associated with T2DM.
Conclusion
We determined the expression profiles of miRNAs in the obese population, with and without diabetes, before and after bariatric surgery. The miRNAs that intersected in the two comparisons were discovered. Both the miRNAs discovered and their target genes were closely associated with T2DM, demonstrating that they might be potential targets for the regulation of T2DM.

Citations

Citations to this article as recorded by

Early changes of microRNAs in blood one month after bariatric surgery
Guanhua Lu, Huanhuan Gao, Ruixiang Hu, Ji Miao, Zhiyong Dong, Cunchuan Wang, Xinxin Chen
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef

Basic Research
N⁶-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis: Yuan Tian, Yue-Hai Xiao, Chao Sun, Bei Liu, Fa Sun; Diabetes Metab J. 2023;47(2):287-300. Published online January 19, 2023; DOI: https://doi.org/10.4093/dmj.2021.0306

3,027 View
164 Download
4 Web of Science
4 Crossref

Abstract PDF PubReader ePub

Background
The present study investigated the regulatory effects of N6-methyladenosine (m6A) methyltransferase like-3 (METTL3) in diabetes-induced testicular damage.
Methods
In vivo diabetic mice and high glucose (HG) treated GC-1 spg cells were established. The mRNA and protein expressions were determined by real-time quantitative polymerase chain reaction, Western blot, immunofluorescence and immunohistochemistry staining. Levels of testosterone, blood glucose, cell viability, and apoptosis were detected by enzyme-linked immunosorbent assay, MTT, and flow cytometry, respectively. Molecular interactions were verified by RNA immunoprecipitation and RNA pull-down assay. Histopathological staining was performed to evaluate testicular injury.
Results
METTL3 and long non-coding RNA taurine up-regulated 1 (lncRNA TUG1) were downregulated in testicular tissues of diabetic mice and HG-treated GC-1 spg cells. METTL3 overexpression could reduce the blood glucose level, oxidative stress and testicular damage but enhance testosterone secretion in diabetic mouse model and HG-stimulated GC-1 spg cells. Mechanically, METTL3-mediated m6A methylation enhanced the stability of TUG1, then stabilizing the clusterin mRNA via recruiting serine and arginine rich splicing factor 1. Moreover, inhibition of TUG1/clusterin signaling markedly reversed the protective impacts of METTL3 overexpression on HG-stimulated GC-1 spg cells.
Conclusion
This study demonstrated that METTL3 ameliorated diabetes-induced testicular damage by upregulating the TUG1/clusterin signaling. These data further elucidate the potential regulatory mechanisms of m6A modification on diabetes-induced testicular injury.

Citations

Citations to this article as recorded by

Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre‐Osteoblast Cells Induced by Hydrogen Peroxide
Jiaxin Song, Yuejun Wang, Zhao Zhu, Wanqing Wang, Haoqing Yang, Zhaochen Shan
Advanced Biology.2024;[Epub] CrossRef
Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
Mohammed Ageeli Hakami
Saudi Journal of Biological Sciences.2024; 31(5): 103976. CrossRef
BRD7 facilitates ferroptosis via modulating clusterin promoter hypermethylation and suppressing AMPK signaling in diabetes-induced testicular damage
Yuehai Xiao, Zongjian Liang, Jun Qiao, Zhiqiang Zhu, Bei Liu, Yuan Tian
Molecular Medicine.2024;[Epub] CrossRef
Roles of m6A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death
Yifei Sun, Rongxian Li, Wenhong Li, Nan Zhang, Guofen Liu, Bo Zhao, Zongqin Mei, Shiyan Gu, Zuoshun He
Ecotoxicology and Environmental Safety.2024; 282: 116672. CrossRef

Basic Research
Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis: Xuwen Tang, Qingxin Qin, Wenjing Xu, Xuezhen Zhang; Diabetes Metab J. 2023;47(2):267-286. Published online January 19, 2023; DOI: https://doi.org/10.4093/dmj.2021.0216

3,977 View
207 Download
6 Web of Science
5 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated gene 1 (TUG1) influences insulin resistance (IR) in a high-fat diet (HFD)-induced mouse model of GDM.
Methods
We initially developed a mouse model of HFD-induced GDM, from which islet tissues were collected for RNA and protein extraction. Interactions among lncRNA TUG1/microRNA (miR)-328-3p/sterol regulatory element binding protein 2 (SREBP-2) were assessed by dual-luciferase reporter assay. Fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA pancreatic β-cell function (HOMA-β), insulin sensitivity index for oral glucose tolerance tests (ISOGTT) and insulinogenic index (IGI) levels in mouse serum were measured through conducting gain- and loss-of-function experiments.
Results
Abundant expression of miR-328 and deficient expression of lncRNA TUG1 and SREBP-2 were characterized in the islet tissues of mice with HFD-induced GDM. LncRNA TUG1 competitively bound to miR-328-3p, which specifically targeted SREBP-2. Either depletion of miR-328-3p or restoration of lncRNA TUG1 and SREBP-2 reduced the FBG, FINS, HOMA-β, and HOMA-IR levels while increasing ISOGTT and IGI levels, promoting the expression of the extracellular signal-regulated kinase (ERK) signaling pathway-related genes, and inhibiting apoptosis of islet cells in GDM mice. Upregulation miR-328-3p reversed the alleviative effects of SREBP-2 and lncRNA TUG1 on IR.
Conclusion
Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR-328-3p and promoting the SREBP-2-mediated ERK signaling pathway inactivation.

Citations

Citations to this article as recorded by

Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
Mohammed Ageeli Hakami
Saudi Journal of Biological Sciences.2024; 31(5): 103976. CrossRef
Effect of Tinospora cordifolia on gestational diabetes mellitus and its complications
Ritu Rani, Havagiray Chitme, Avinash Kumar Sharma
Women & Health.2023; 63(5): 359. CrossRef
Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model
Ritu Rani, Avinash Kumar Sharma, Havagiray R Chitme
Clinical Medicine Insights: Endocrinology and Diabetes.2023;[Epub] CrossRef
The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes
Dong Gao, Liping Ren, Yu-Duo Hao, Nalini Schaduangrat, Xiao-Wei Liu, Shi-Shi Yuan, Yu-He Yang, Yan Wang, Watshara Shoombuatong, Hui Ding
Briefings in Bioinformatics.2023;[Epub] CrossRef
lncRNA TUG1 as Potential Novel Biomarker for Prognosis of Cardiovascular Diseases
Habib Haybar, Narjes Sadat Sadati, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Epigenomics.2023; 15(23): 1273. CrossRef

Type 1 Diabetes
Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus: Yangyang Li, Ying Zhou, Minghui Zhao, Jing Zou, Yuxiao Zhu, Xuewen Yuan, Qianqi Liu, Hanqing Cai, Cong-Qiu Chu, Yu Liu; Diabetes Metab J. 2020;44(6):854-865. Published online July 13, 2020; DOI: https://doi.org/10.4093/dmj.2019.0151

6,881 View
151 Download
24 Web of Science
23 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that have been documented as potential biomarkers for various diseases. Our objective was to identify and analyze plasma circRNAs altered in T1DM.

Methods

We used microarray to screen differentially expressed plasma circRNAs in patients with new onset T1DM (n=3) and age-/gender-matched healthy controls (n=3). Then, we selected six candidates with highest fold-change and validated them by quantitative real-time polymerase chain reaction in independent human cohort samples (n=12). Bioinformatic tools were adopted to predict putative microRNAs (miRNAs) sponged by these validated circRNAs and their downstream messenger RNAs (mRNAs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to gain further insights into T1DM pathogenesis.

Results

We identified 68 differentially expressed circRNAs, with 61 and seven being up- and downregulated respectively. Four of the six selected candidates were successfully validated. Curations of their predicted interacting miRNAs revealed critical roles in inflammation and pathogenesis of autoimmune disorders. Functional relations were visualized by a circRNA-miRNA-mRNA network. GO and KEGG analyses identified multiple inflammation-related processes that could be potentially associated with T1DM pathogenesis, including cytokine-cytokine receptor interaction, inflammatory mediator regulation of transient receptor potential channels and leukocyte activation involved in immune response.

Conclusion

Our study report, for the first time, a profile of differentially expressed plasma circRNAs in new onset T1DM. Further in silico annotations and bioinformatics analyses supported future application of circRNAs as novel biomarkers of T1DM.

Citations

Citations to this article as recorded by

Non-coding RNAs and exosomal non-coding RNAs in diabetic retinopathy: A narrative review
Yuhong Zhong, Juan Xia, Li Liao, Mohammad Reza Momeni
International Journal of Biological Macromolecules.2024; 259: 128182. CrossRef
Circular RNAs: Potential biomarkers and therapeutic targets for autoimmune diseases
Ren-Jie Zhao, Wan-Ying Zhang, Xing-Xing Fan
Heliyon.2024; 10(1): e23694. CrossRef
Hsa_circRNA_405498 and hsa_circRNA_100033 Serve as Potential Biomarkers for Differential Diagnosis of Type 1 Diabetes
Ziwei Zhang, Shuoming Luo, Zilin Xiao, Wenfeng Yin, Xiajie Shi, Hongzhi Chen, Zhiguo Xie, Zhenqi Liu, Xia Li, Zhiguang Zhou
The Journal of Clinical Endocrinology & Metabolism.2024; 109(6): 1464. CrossRef
A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond
Pengqiang Zhong, Lu Bai, Mengzhi Hong, Juan Ouyang, Ruizhi Wang, Xiaoli Zhang, Peisong Chen
Diagnostics.2024; 14(10): 1045. CrossRef
Circulating non-coding RNA in type 1 diabetes mellitus as a source of potential biomarkers – An emerging role of sex difference
Lucyna Stachowiak, Weronika Kraczkowska, Aleksandra Świercz, Paweł Piotr Jagodziński
Biochemical and Biophysical Research Communications.2024; 736: 150482. CrossRef
Importance of Studying Non-Coding RNA in Children and Adolescents with Type 1 Diabetes
Manuela Cabiati, Giovanni Federico, Silvia Del Ry
Biomedicines.2024; 12(9): 1988. CrossRef
Circular RNAs in human diseases
Yuanyong Wang, Jin Zhang, Yuchen Yang, Zhuofeng Liu, Sijia Sun, Rui Li, Hui Zhu, Tian Li, Jin Zheng, Jie Li, Litian Ma
MedComm.2024;[Epub] CrossRef
Research progress of circular RNA molecules in aging and age-related diseases
Zhidan Zhang, Yuling Huang, AYao Guo, Lina Yang
Ageing Research Reviews.2023; 87: 101913. CrossRef
CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders
Yuka Ikeda, Sae Morikawa, Moeka Nakashima, Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Naoko Suga, Ai Tsuji, Satoru Matsuda
Non-Coding RNA.2023; 9(2): 23. CrossRef
Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications
Zi Li, Yuanyuan Ren, Ziwei Lv, Man Li, Yujia Li, Xiaobin Fan, Yuyan Xiong, Lu Qian
Biomedicine & Pharmacotherapy.2023; 168: 115744. CrossRef
Circular RNA PIP5K1A Promotes Glucose and Lipid Metabolism Disorders and Inflammation in Type 2 Diabetes Mellitus
Ge Song, YiQian Zhang, YiHua Jiang, Huan Zhang, Wen Gu, Xiu Xu, Jing Yao, ZhengFang Chen
Molecular Biotechnology.2023;[Epub] CrossRef
Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1
Lei Ren
Bioengineered.2022; 13(3): 5724. CrossRef
Circular RNAs in diabetes mellitus and its complications
Wenqi Fan, Haipeng Pang, Zhiguo Xie, Gan Huang, Zhiguang Zhou
Frontiers in Endocrinology.2022;[Epub] CrossRef
Type 1 Diabetes Mellitus-Related circRNAs Regulate CD4+ T Cell Functions
Jianni Chen, Guanfei Jia, Xue Lv, Shufa Li, Christos K. Kontos
BioMed Research International.2022; 2022: 1. CrossRef
An intriguing role of circular RNA in insulin resistance and endothelial dysfunction: the future perspectives
Monisha Prasad, Selvaraj Jayaraman, Vishnu Priya Veeraraghavan
Hypertension Research.2022; 45(11): 1843. CrossRef
Circular RNAs in Diabetic Nephropathy: Updates and Perspectives
Miao Liu, Junli Zhao
Aging and disease.2022; 13(5): 1365. CrossRef
CircRNAs: Key molecules in the prevention and treatment of ischemic stroke
Zeyu Liu, Yanhong Zhou, Jian Xia
Biomedicine & Pharmacotherapy.2022; 156: 113845. CrossRef
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Simranjeet Kaur, Caroline Frørup, Aashiq H. Mirza, Tina Fløyel, Reza Yarani, Maikel L. Colli, Jesper Johannesen, Joachim Størling, Decio L. Eizirik, Flemming Pociot
Non-Coding RNA.2022; 8(5): 69. CrossRef
Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus
Haipeng Pang, Wenqi Fan, Xiajie Shi, Shuoming Luo, Yimeng Wang, Jian Lin, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou, Jinhui Liu
Journal of Immunology Research.2022; 2022: 1. CrossRef
Circular RNAs in diabetes and its complications: Current knowledge and future prospects
Wenfeng Yin, Ziwei Zhang, Zilin Xiao, Xia Li, Shuoming Luo, Zhiguang Zhou
Frontiers in Genetics.2022;[Epub] CrossRef
Circular RNA in autoimmune diseases: special emphasis on regulation mechanism in RA and SLE
Yurong Huang, Qiuyun Xue, Chenglong Cheng, Yuting Wang, Xiao Wang, Jun Chang, Chenggui Miao
Journal of Pharmacy and Pharmacology.2022;[Epub] CrossRef
Emerging roles of circular RNAs in systemic lupus erythematosus
Xin Wang, Rui Ma, Weimin Shi, Zhouwei Wu, Yuling Shi
Molecular Therapy - Nucleic Acids.2021; 24: 212. CrossRef
Understanding Competitive Endogenous RNA Network Mechanism in Type 1 Diabetes Mellitus Using Computational and Bioinformatics Approaches
Xuanzi Yi, Xu Cheng
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3865. CrossRef

Short Communication

Clinical Diabetes & Therapeutics
Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients: Ilenia Cirilli, Sonia Silvestri, Fabio Marcheggiani, Fabiola Olivieri, Roberta Galeazzi, Roberto Antonicelli, Rina Recchioni, Fiorella Marcheselli, Tiziana Bacchetti, Luca Tiano, Patrick Orlando; Diabetes Metab J. 2019;43(6):893-897. Published online June 27, 2019; DOI: https://doi.org/10.4093/dmj.2018.0254

4,550 View
53 Download
9 Web of Science
10 Crossref

Abstract PDF PubReader

Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

Citations

Citations to this article as recorded by

Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
Dharmsheel Shrivastav, Desh Deepak Singh
World Journal of Clinical Cases.2024; 12(3): 525. CrossRef
Is It Possible to Train the Endothelium?—A Narrative Literature Review
Karolina Biernat, Natalia Kuciel, Justyna Mazurek, Katarzyna Hap
Life.2024; 14(5): 616. CrossRef
The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases—A Systematic Review
Moomna Afzal, Francesca Greco, Federico Quinzi, Francesca Scionti, Samantha Maurotti, Tiziana Montalcini, Annamaria Mancini, Pasqualina Buono, Gian Pietro Emerenziani
International Journal of Molecular Sciences.2024; 25(13): 6813. CrossRef
Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies
Yang Chen, Xingsheng Jin, Guochong Chen, Ru Wang, Haili Tian
JMIR Public Health and Surveillance.2024; 10: e54318. CrossRef
Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases
Waleska Dornas, Maisa Silva
Nutrition, Metabolism and Cardiovascular Diseases.2024;[Epub] CrossRef
Effects of Seven Weeks of Combined Physical Training on High-Density Lipoprotein Functionality in Overweight/Obese Subjects
Tiziana Bacchetti, Camilla Morresi, Gianna Ferretti, Anders Larsson, Torbjörn Åkerfeldt, Michael Svensson
Metabolites.2023; 13(10): 1068. CrossRef
Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
Juan Gao, Xue Pan, Guoping Li, Emeli Chatterjee, Junjie Xiao
Journal of Cardiovascular Translational Research.2022; 15(3): 604. CrossRef
Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells
William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
International Journal of Sports Medicine.2021; 42(12): 1047. CrossRef
Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes
Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Aneta Balcerczyk, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
International Journal of Molecular Sciences.2021; 22(13): 6964. CrossRef
The Potential Role of MicroRNA in Diabetic Cardiomyopathy
Jin Hwa Kim
Diabetes & Metabolism Journal.2020; 44(1): 54. CrossRef

Original Articles

Technology/Device
Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy: In-Hwa Park, Yi-Sun Song, Hyun-Woo Joo, Guang-Yin Shen, Jin-Hee Seong, Na-Kyoung Shin, Young Jong Cho, Yonggu Lee, Jeong Hun Shin, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim; Diabetes Metab J. 2020;44(1):173-185. Published online April 23, 2019; DOI: https://doi.org/10.4093/dmj.2018.0211

6,122 View
81 Download
12 Web of Science
11 Crossref

Abstract PDF Supplementary Material PubReader

Background

Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated cardiomyocyte apoptosis in a rat model of diabetic cardiomyopathy. In this study, we hypothesized a regulatory role of cardiac miRNAs in the mechanism of the anti-apoptotic effect of G-CSF in a diabetic cardiomyopathy rat model.

Methods

Rats were given a high-fat diet and low-dose streptozotocin injection and then randomly allocated to receive treatment with either G-CSF or saline. H9c2 rat cardiomyocytes were cultured under a high glucose (HG) condition to induce diabetic cardiomyopathy in vitro. We examined the extent of apoptosis, miRNA expression, and miRNA target genes in the myocardium and H9c2 cells.

Results

G-CSF treatment significantly decreased apoptosis and reduced miR-34a expression in diabetic myocardium and H9c2 cells under the HG condition. G-CSF treatment also significantly increased B-cell lymphoma 2 (Bcl-2) protein expression as a target for miR-34a. In addition, transfection with an miR-34a mimic significantly increased apoptosis and decreased Bcl-2 luciferase activity in H9c2 cells.

Conclusion

Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model.

Citations

Citations to this article as recorded by

The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy
Bingrui Zhang, Hua Wu, Jingwen Zhang, Cong Cong, Lin Zhang
Molecular and Cellular Biochemistry.2024; 479(7): 1673. CrossRef
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction
Elisabeth A. Jalink, Amber W. Schonk, Reinier A. Boon, Rio P. Juni
Frontiers in Cardiovascular Medicine.2024;[Epub] CrossRef
The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy
Hao Wu, Yan Liu, Chunli Liu
Non-coding RNA Research.2024; 9(4): 1080. CrossRef
Dynamic interplay of microRNA in diseases and therapeutic
Neha Kargutkar, Priya Hariharan, Anita Nadkarni
Clinical Genetics.2023; 103(3): 268. CrossRef
LGR5+ Intestinal Stem Cells Display Sex-Dependent Radiosensitivity
Ryan C. Zitter, Rishi Man Chugh, Payel Bhanja, Bruce F. Kimler, Subhrajit Saha
Cells.2023; 13(1): 46. CrossRef
Female Mice are More Resistant to the Mixed-Field (67% Neutron + 33% Gamma) Radiation-Induced Injury in Bone Marrow and Small Intestine than Male Mice due to Sustained Increases in G-CSF and the Bcl-2/Bax Ratio and Lower miR-34a and MAPK Activation
Juliann G. Kiang, Georgetta Cannon, Matthew G. Olson, Joan T. Smith, Marsha N. Anderson, Min Zhai, M. Victoria Umali, Kevin Ho, Connie Ho, Wanchang Cui, Mang Xiao
Radiation Research.2022;[Epub] CrossRef
Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of Type 2 Diabetes Mellitus
Han Wang, Cheng Tang, Zezheng Gao, Yishan Huang, Boxun Zhang, Jiahua Wei, Linhua Zhao, Xiaolin Tong, Yong Xu
Journal of Diabetes Research.2021; 2021: 1. CrossRef
Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma
Juliann G. Kiang, Joan T. Smith, Georgetta Cannon, Marsha N. Anderson, Connie Ho, Min Zhai, Wanchang Cui, Mang Xiao
Cell & Bioscience.2020;[Epub] CrossRef
Evaluation of biomarkers in liver following Solanum melongena green calyx administration in diabetic rats
Shiva Roshankhah, Ahmad Shabanizadeh, Amir Abdolmaleki, Mohammad Reza Gholami, Mohammad Reza Salahshoor
Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1115. CrossRef
Diabetic cardiomyopathy: definition, diagnosis criteria, treatment directions and prevention of heart failure
N. A. Koziolova, P. G. Karavaev, A. S. Veklich
South Russian Journal of Therapeutic Practice.2020; 1(2): 93. CrossRef
The Potential Role of MicroRNA in Diabetic Cardiomyopathy
Jin Hwa Kim
Diabetes & Metabolism Journal.2020; 44(1): 54. CrossRef

Clinical Care/Education
Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients: Mei Uemura, Yutaka Yano, Toshinari Suzuki, Taro Yasuma, Toshiyuki Sato, Aya Morimoto, Samiko Hosoya, Chihiro Suminaka, Hiromu Nakajima, Esteban C. Gabazza, Yoshiyuki Takei; Diabetes Metab J. 2017;41(4):265-274. Published online July 31, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.4.265

5,159 View
59 Download
4 Web of Science
2 Crossref

Abstract PDF PubReader

Background

Continuous glucose monitoring (CGM) is reported to be a useful technique, but difficult or inconvenient for some patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hyperglycemia using CGM data as a reference.

Methods

Thirty-eight inpatients with diabetes undergoing CGM were enrolled. MIET comprised a pretreatment step using a plastic microneedle array and glucose accumulation step with a hydrogel patch, which was placed on two sites from 9:00 AM to 5:00 PM or from 10:00 PM to 6:00 AM. IG AUC was calculated by accumulated glucose extracted by hydrogel patches using sodium ion as standard.

Results

A significant correlation was observed between the predicted AUC by MIET and CGM in daytime (r=0.76) and nighttime (r=0.82). The optimal cutoff for the IG AUC value of MIET to predict hyperglycemia over 200 mg/dL measured by CGM for 8 hours was 1,067.3 mg·hr/dL with 88.2% sensitivity and 81.5% specificity.

Conclusion

We showed that 8-hour IG AUC levels using MIET were valuable in estimating the blood glucose AUC without blood sampling. The results also supported the concept of using this technique for evaluating glucose excursion and for screening hyperglycemia during 8 hours in patients with diabetes at any time of day.

Citations

Citations to this article as recorded by

Efficacy of Postprandial Exercise in Mitigating Glycemic Responses in Overweight Individuals and Individuals with Obesity and Type 2 Diabetes—A Systematic Review and Meta-Analysis
Jie Kang, Brian M. Fardman, Nicholas A. Ratamess, Avery D. Faigenbaum, Jill A. Bush
Nutrients.2023; 15(20): 4489. CrossRef
Multifunctional Wearable System that Integrates Sweat‐Based Sensing and Vital‐Sign Monitoring to Estimate Pre‐/Post‐Exercise Glucose Levels
Yongseok Joseph Hong, Hyunjae Lee, Jaemin Kim, Minha Lee, Hyung Jin Choi, Taeghwan Hyeon, Dae‐Hyeong Kim
Advanced Functional Materials.2018;[Epub] CrossRef

Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells: Hae-Jung Lee, Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Jong-Keun Son, Yong-Woon Kim; Diabetes Metab J. 2015;39(1):51-58. Published online February 16, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.1.51

4,908 View
74 Download
11 Web of Science
8 Crossref

Abstract PDF PubReader

Background

Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic β-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is essential for the management of type 2 diabetes. In this study, we evaluated the ability of an Orthosiphon stamineus (OS) extract to prevent glucotoxicity in insulin-producing cells.

Methods

We measured insulin mRNA expression and glucose-stimulated insulin secretion (GSIS) in OS-treated INS-1 cells after exposure to a high glucose (HG; 30 mM) concentration.

Results

The hexane extract of OS elevated mRNA expression of insulin as well as pancreatic and duodenal homeobox-1 of INS-1 cells in a dose-dependent manner. The hexane OS extract also increased the levels of phosphorylated phosphatidylinositol 3-kinase (PI3K) in a concentration-dependent manner. Additionally, Akt phosphorylation was elevated by treatment with 100 and 200 µmol of the hexane OS extract. Three days of HG exposure suppressed insulin mRNA expression and GSIS; these expressions were restored by treatment with the hexane OS extract. HG elevated peroxide levels in the INS-1 cells. These levels were unaffected by OS treatment under both normal and hyperglycemic conditions.

Conclusion

Our results suggested that the hexane extract of OS elevates insulin mRNA expression and prevents glucotoxicity induced by a 3-day treatment with HG. This was associated with the activation of PI-3K and Akt.

Citations

Citations to this article as recorded by

An Updated Review of Ethnobotany, Ethnopharmacology, Phytochemistry and Pharmacological Activities of Orthosiphon stamineus Benth
Anandarajagopal Kalusalingam, Dania Najiha Hasnu, Abdullah Khan, Ching Siang Tan, Bama Menon, Venkateshan Narayanan, Khang Wen Goh, Asmuni Mohd Ikmal, Noraini Talip, Poonguzhali Subramanian, Long Chiau Ming
Malaysian Applied Biology.2024; 53(1): 1. CrossRef
Scopoletin protects INS-1 pancreatic β cells from glucotoxicity by reducing oxidative stress and apoptosis
Jae Eun Park, Ji Sook Han
Toxicology in Vitro.2023; 93: 105665. CrossRef
A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications
Qirou Wang, Jia Wang, Nannan Li, Junyu Liu, Jingna Zhou, Pengwei Zhuang, Haixia Chen
Molecules.2022; 27(2): 444. CrossRef
Comprehensive chemical and metabolic profiling of anti‐hyperglycemic active fraction from Clerodendranthi Spicati Herba
Yun Luo, Yue Liu, Quan Wen, Yulin Feng, Ting Tan
Journal of Separation Science.2021; 44(9): 1805. CrossRef
Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect
Krista Minéia Wartchow, Letícia Rodrigues, Lucas Zingano Suardi, Barbara Carolina Federhen, Nicholas Guerini Selistre, Carlos-Alberto Gonçalves, Patrícia Sesterheim
International Journal of Molecular Sciences.2019; 20(10): 2458. CrossRef
Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
Chintha Lankatillake, Tien Huynh, Daniel A. Dias
Plant Methods.2019;[Epub] CrossRef
50% Ethanol extract of Orthosiphon stamineus modulates genotoxicity and clastogenicity induced by mitomycin C
Dhamraa Waleed Al-dualimi, Aman Shah Abdul Majid, Sarah Furqan Faisal Al-Shimary, Amal Aziz Al-Saadi, Raghdaa Al Zarzour, Muhammad Asif, Chern Ein Oon, Amin Malik Shah Abdul Majid
Drug and Chemical Toxicology.2018; 41(1): 82. CrossRef
Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?
Heeyoung Chae, Patrick Gilon
Diabetes & Metabolism Journal.2015; 39(1): 27. CrossRef

Perspective

Journal Metrics-Based Position of Diabetes & Metabolism Journal after the Change of Its Text Language to English: Sun Huh; Diabetes Metab J. 2014;38(3):187-193. Published online June 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.3.187

4,012 View
29 Download
7 Web of Science
8 Crossref

Abstract PDF PubReader

After changing its language from Korean or English to English only in 2010, the journal metrics of Diabetes & Metabolism Journal (DMJ) were analyzed to assess whether this change in the journal policy was successful. The journal metric items that were analyzed were the following: impact factor; total citations; countries of authors; proportion of the articles funded out of the total number of original articles; and Hirsch-index (H-index). A retrospective, descriptive analysis was carried out using various databases, such as KoreaMed, Korean Medical Citation Index (KoMCI), KoreaMed Synapse, Web of Science, and Journal Citation Ranking. The journal's impact factor was 2.054, which corresponds to 83/122 (68.0%) out of the 2012 JCR endocrinology and metabolism category. The number of the journal's total citations was 330 in 2013. In addition to Korean authors, authors from 13 other countries published papers in the journal from 2010 to 2013. The number of funded papers from 2010 to 2013 was 65 out of 148 original articles (43.9%). The journal's H-index from KoreaMed Synapse was 7, and that from Web of Science was 9. It can be concluded that changing the journal's language to English was successful based on journal metrics. DMJ is currently positioned as an international journal based on the international diversity of authors and editors, its sufficiently high proportion of funded articles, its relatively high impact factor, and the number of total citations.

Citations

Citations to this article as recorded by

Journal of Gastric Cancer's Promotion to International Journal from the Perspective of Biliometric Analysis
Sun Huh
Journal of Gastric Cancer.2016; 16(1): 8. CrossRef
Clinics in Orthopedic Surgery's Evolution into an International Journal Based on Journal Metrics
Sun Huh
Clinics in Orthopedic Surgery.2016; 8(2): 127. CrossRef
Promotion ofNeurointerventionto International Journal Based on Journal Metrics
Sun Huh
Neurointervention.2016; 11(1): 5. CrossRef
How much progress has been made in journal metrics two years after the citation analysis of theKorean Journal of Urology?
Sun Huh
Korean Journal of Urology.2015; 56(4): 276. CrossRef
Evidence of the Internationalization ofClinical EndoscopyBased on Journal Metrics
Sun Huh
Clinical Endoscopy.2015; 48(4): 317. CrossRef
The Elevation ofAnnals of Rehabilitation Medicineto the Status of an International Journal After Adopting an English-Only Policy
Sun Huh
Annals of Rehabilitation Medicine.2015; 39(5): 661. CrossRef
What is the position ofClinical and Experimental Reproductive Medicinein its scholarly journal network based on journal metrics?
Sun Huh
Clinical and Experimental Reproductive Medicine.2014; 41(4): 147. CrossRef
How Journal Metrics Illustrate the Transformation of Archives of Plastic Surgery into an International Journal
Sun Huh
Archives of Plastic Surgery.2014; 41(06): 617. CrossRef

Original Articles

Low Levels of Physical Activity Are Associated with Increased Metabolic Syndrome Risk Factors in Korean Adults: Dong Hoon Lee, Yoon Myung Kim, Yoonsuk Jekal, Sukyung Park, Kyong-Chol Kim, Masayo Naruse, Sun Hyun Kim, Sang-Hwan Kim, Ji-Hye Park, Mi Kyung Lee, Sang Hui Chu, Justin Y. Jeon; Diabetes Metab J. 2013;37(2):132-139. Published online April 16, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.2.132

5,138 View
34 Download
22 Crossref

Abstract PDF PubReader

Background

Low levels of physical activity (PA) are strongly associated with the development of metabolic syndrome (MetS) and chronic diseases. However, few studies have examined this association in Koreans. The primary purpose of this study was to examine the associations between PA and MetS risks in Korean adults.

Methods

A total of 1,016 Korean adults (494 males and 522 females) participated in this study. PA levels were assessed using the International PA Questionnaire. MetS risk factors were determined using clinically established diagnostic criteria.

Results

Compared with the highest PA group, the group with the lowest level of PA was at greater risk of high triglyceride (TG) in males (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.07 to 3.24) and of hemoglobin A1c ≥5.5% in females (OR, 1.75; 95% CI, 1.00 to 3.04) after adjusting for age and body mass index. Compared with subjects who met the PA guidelines, those who did not meet the guidelines were more likely to have low high density lipoprotein cholesterol in both males (OR, 1.69; 95% CI, 1.11 to 2.58), and females (OR, 1.82; 95% CI, 1.20 to 2.77). Furthermore, those who did not meet the PA guidelines were at increased risk of high TG levels in males (OR, 1.69; 95% CI, 1.23 to 2.86) and abnormal fasting glucose (OR, 1.93; 95% CI, 1.17 to 3.20) and MetS (OR, 2.10; 95% CI, 1.15 to 3.84) in females.

Conclusion

Increased levels of PA are significantly associated with a decreased risk of abnormal MetS components.

Citations

Citations to this article as recorded by

Effects of a Physical Exercise Programme through Service-Learning Methodology on Physical Activity, Physical Fitness and Perception of Physical Fitness and Health in University Students from Spain: A Preliminary Study
Antonio Jesús Casimiro-Andújar, Eva Artés-Rodríguez, David M. Díez-Fernández, María-Jesús Lirola
International Journal of Environmental Research and Public Health.2023; 20(4): 3377. CrossRef
The Effect of a Mobile and Wearable Device Intervention on Increased Physical Activity to Prevent Metabolic Syndrome: Observational Study
Hee Jin Kim, Kang Hyun Lee, Jung Hun Lee, Hyun Youk, Hee Young Lee
JMIR mHealth and uHealth.2022; 10(2): e34059. CrossRef
Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?
Şeyda TOPRAK ÇELENAY, Derya ÖZER KAYA, Senem ŞAŞ
Clinical and Experimental Health Sciences.2022; 12(4): 793. CrossRef
Associations of Preoperative Irisin Levels of Paired Cerebrospinal Fluid and Plasma with Physical Dysfunction and Muscle Wasting Severity in Residents of Surgery Wards
Q. Ruan, Y. Huang, L. Yang, J. Li, W. Gu, Z. Bao, X. Zhang, Zhuowei Yu
The Journal of nutrition, health and aging.2020; 24(4): 412. CrossRef
The mulberry-derived 1-deoxynojirimycin (DNJ) inhibits high-fat diet (HFD)-induced hypercholesteremia and modulates the gut microbiota in a gender-specific manner
Yougui Li, Shi Zhong, Jiaqi Yu, Yuqing Sun, Jianxun Zhu, Dongfeng Ji, Chongming Wu
Journal of Functional Foods.2019; 52: 63. CrossRef
Association between Metabolic Syndrome Criteria and Lifestyle Category among University Academic Staff in West Java, Indonesia
Vita Murniati T, Siti Nur Fatima, Titing Nurhayati, Mohammad Rizki Akba, Putri Teesa Radh, Ambrosius Purba, Ieva Baniasih A, Hanna Goenawan
Pakistan Journal of Nutrition.2018; 17(12): 709. CrossRef
Association between serum lipids concentration and patients with age-related cataract in China: a cross-sectional, case–control study
Shengjie Li, Danhui Li, Yudong Zhang, Jisen Teng, Mingxi Shao, Wenjun Cao
BMJ Open.2018; 8(4): e021496. CrossRef
Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) style diet, and metabolic health in U.S. adults
Yong-Moon Mark Park, Susan E. Steck, Teresa T. Fung, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Hyuk-Sang Kwon, Anwar T. Merchant
Clinical Nutrition.2017; 36(5): 1301. CrossRef
The association between metabolic health, obesity phenotype and the risk of breast cancer
Yong‐Moon Mark Park, Alexandra J. White, Hazel B. Nichols, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler
International Journal of Cancer.2017; 140(12): 2657. CrossRef
Sedentary Occupation Workers Who Meet the Physical Activity Recommendations Have a Reduced Risk for Metabolic Syndrome
Rodrigo Alberto Vieira Browne, Luiz Fernando Farias-Junior, Yuri Alberto Freire, Daniel Schwade, Geovani de Araújo Dantas de Macêdo, Vilma Bayma Montenegro, Thiago Jambo Alves Lopes, Filipe Fernandes Oliveira Dantas, Eduardo Caldas Costa
Journal of Occupational & Environmental Medicine.2017; 59(11): 1029. CrossRef
Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
International Journal of Obesity.2016; 40(10): 1541. CrossRef
Diet Quality and Mortality Risk in Metabolically Obese Normal-Weight Adults
Yong-Moon Mark Park, Teresa T. Fung, Susan E. Steck, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T. Merchant
Mayo Clinic Proceedings.2016; 91(10): 1372. CrossRef
Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey
Se-Hwan Hwang, Jun-Myung Kang, Jae-Hyun Seo, Kyung-do Han, Young-Hoon Joo, Yiqing Song
PLOS ONE.2016; 11(2): e0148813. CrossRef
Renal posttransplantation diabetes mellitus: An overview
Ana Laura Pimentel, Andrea Carla Bauer, Joíza Lins Camargo
Clinica Chimica Acta.2015; 450: 327. CrossRef
Metabolic Syndrome and Chronic Laryngitis
Choung-Soo Kim, Seong-Soo Lee, Kyung-do Han, Young-Hoon Joo
Medicine.2015; 94(43): e1890. CrossRef
Gender differences in the association between food insecurity and insulin resistance among U.S. adults: National Health and Nutrition Examination Survey, 2005–2010
Junxiu Liu, Yong-Moon Mark Park, Seth A. Berkowitz, Qingwei Hu, Kyungdo Han, Andrew Ortaglia, Robert E. McKeown, Angela D. Liese
Annals of Epidemiology.2015; 25(9): 643. CrossRef
Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans
Hae Yoon Choi, Sungeun Kim, Ji Woo Park, Nam Seok Lee, Soon Young Hwang, Joo Young Huh, Ho Cheol Hong, Hye Jin Yoo, Sei Hyun Baik, Byung-Soo Youn, Christos S. Mantzoros, Kyung Mook Choi
The Journal of Clinical Endocrinology & Metabolism.2014; 99(8): 2778. CrossRef
Relationship between Physical Activity Level, Amount of Alcohol Consumption and Metabolic Syndrome in Korean Male Drinkers
Byung-Sung Kim, Myeong-Jin Kim, Hyun-Rim Choi, Cahng-Won Won, Sun-Young Kim
The Korean Journal of Sports Medicine.2014; 32(2): 97. CrossRef
Association between cardiorespiratory fitness and the prevalence of metabolic syndrome among Korean adults: a cross sectional study
Sunghyun Hong, Junga Lee, Jihye Park, Mikyung Lee, Ji Young Kim, Kyong-Chol Kim, Sun Hyun Kim, Jee Aee Im, Sang Hui Chu, Sang Hoon Suh, Sang Hwan Kim, Justin Y Jeon
BMC Public Health.2014;[Epub] CrossRef
Impact of lifestyle on metabolic syndrome in apparently healthy people
Silvio Buscemi, Delia Sprini, Giuseppe Grosso, Fabio Galvano, Antonio Nicolucci, Giuseppe Lucisano, Fatima M. Massenti, Emanuele Amodio, Giovam B. Rini
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2014; 19(2): 225. CrossRef
Gender Difference in the Association of Metabolic Syndrome and Its Components with Age-Related Cataract: The Korea National Health and Nutrition Examination Survey 2008-2010
Young-Hoon Park, Jeong Ah Shin, Kyungdo Han, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park, Yingfeng Zheng
PLoS ONE.2014; 9(1): e85068. CrossRef
Prevalence of Metabolic Syndrome and Its Relationship with Physical Activity in Suburban Beijing, China
Wei-Hong Zhang, Peng Xue, Meng-Ying Yao, Hai-Min Chang, Yan Wu, Lei Zhang
Annals of Nutrition and Metabolism.2013; 63(4): 298. CrossRef

Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers: Sang Ah Lee, Eunheiu Jeong, Eun Hee Kim, Mi-Seon Shin, Jenie Yoonoo Hwang, Eun Hee Koh, Woo Je Lee, Joong-Yeol Park, Min-Seon Kim; Diabetes Metab J. 2012;36(1):29-36. Published online February 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.1.29

4,215 View
39 Download
13 Crossref

Abstract PDF PubReader

Background

Fibroblast growth factor 21 (FGF21) was originally identified as a paroxysm proliferator activated receptor-α target gene product and is a hormone involved in metabolic regulation. The purpose of this study was to investigate the diurnal variation of serum FGF21 concentration in obese and non-obese healthy volunteers.

Methods

Blood samples were collected from five non-obese (body mass index [BMI] ≤23 kg/m²) and five obese (BMI ≥25 kg/m²) healthy young men every 30 to 60 minutes over 24 hours. Serum FGF21 concentrations were determined by radioimmunoassay. Anthropometric parameters, glucose, free fatty acid, insulin, leptin, and cortisol concentrations were also measured.

Results

The serum FGF21 concentrations displayed various individual oscillation patterns. The oscillation frequency ranged between 6 and 12 times per day. The average duration of oscillation was 2.52 hours (range, 1.9 to 3.0 hours). The peaks and troughs of FGF21 oscillation showed no circadian rhythm. However, the oscillation frequency had a diurnal variation and was lower during the light-off period than during the light-on period (2.4 vs. 7.3 times, P<0.001). There was no difference in the total frequency or duration of oscillations between non-obese and obese subjects, but obese individuals had increased numbers of larger oscillations (amplitude ≥0.19 ng/mL).

Conclusion

Various oscillation patterns in serum FGF21 concentration were observed, and reduced oscillation frequencies were seen during sleep. The oscillation patterns of serum FGF21 concentration suggest that FGF21 may be secreted into systemic circulation in a pulsatile manner. Obesity appeared to affect the amplitude of oscillations of serum FGF21.

Citations

Citations to this article as recorded by

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism
Zhenning Yang, Helmut Zarbl, Grace L. Guo
Molecular Pharmacology.2024; : MOLPHARM-MR-2023-000831. CrossRef
Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial
Luiz Eduardo Mateus Brandão, Daniel Espes, Jakub Orzechowski Westholm, Teemu Martikainen, Nestori Westerlund, Lauri Lampola, Alexandru Popa, Heike Vogel, Annette Schürmann, Suzanne L. Dickson, Christian Benedict, Jonathan Cedernaes
Journal of Sleep Research.2022;[Epub] CrossRef
Metabolic Stress Index Including Mitochondrial Biomarker for Noninvasive Diagnosis of Hepatic Steatosis
Jae Seung Chang, Jhii-Hyun Ahn, Seong Hee Kang, Sang-Baek Koh, Jang-Young Kim, Soon Koo Baik, Ji Hye Huh, Samuel S. Lee, Moon Young Kim, Kyu-Sang Park
Frontiers in Endocrinology.2022;[Epub] CrossRef
Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults
Melissa M. Markofski, Kristofer Jennings, Chad Dolan, Natalie A. Davies, Emily C. LaVoy, Edward J. Ryan, Andres E. Carrillo
American Journal of Lifestyle Medicine.2021; 15(6): 690. CrossRef
Diurnal rhythm in clinical chemistry: An underrated source of variation
Mohamed Abou El Hassan, Edgard Delvin, Manal O. Elnenaei, Barry Hoffman
Critical Reviews in Clinical Laboratory Sciences.2018; 55(8): 516. CrossRef
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Antero Salminen, Kai Kaarniranta, Anu Kauppinen
Cellular Signalling.2017; 40: 10. CrossRef
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Chiara Degirolamo, Carlo Sabbà, Antonio Moschetta
Nature Reviews Drug Discovery.2016; 15(1): 51. CrossRef
Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis
Mark Reinhard, Jan Frystyk, Bente Jespersen, Else Randers, Bo Martin Bibby, Per Ivarsen
Clinical Endocrinology.2015; 83(2): 187. CrossRef
Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice
Xi Wu, Yong-Fen Qi, Jin-Rui Chang, Wei-Wei Lu, Jin-Sheng Zhang, Shao-Ping Wang, Shu-Juan Cheng, Ming Zhang, Qian Fan, Yuan Lv, Hui Zhu, Man-Kun Xin, Yun Lv, Jing-Hua Liu
Heart and Vessels.2015; 30(5): 657. CrossRef
Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal
Bo Angelin, Tobias E. Larsson, Mats Rudling
Cell Metabolism.2012; 16(6): 693. CrossRef
Metabolic actions of fibroblast growth factor 21
Daniel Cuevas-Ramos, Carlos A. Aguilar-Salinas, Francisco J. Gómez-Pérez
Current Opinion in Pediatrics.2012; 24(4): 523. CrossRef
Fibroblast Growth Factor 21: A Novel Metabolic Regulator
Ji A Seo, Nan Hee Kim
Diabetes & Metabolism Journal.2012; 36(1): 26. CrossRef
MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21
Pedro Iglesias, Rafael Selgas, Sara Romero, Juan J Díez
European Journal of Endocrinology.2012; 167(3): 301. CrossRef

First
Prev
Page of 2
Next
Last

Search