Citations

Citations to this article as recorded by  

• From aging to space: A comparative biology of skeletal muscle degeneration
  Rizwan Qaisar
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(1): 168058.     CrossRef
• Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence
  Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo
  The Kaohsiung Journal of Medical Sciences.2026;[Epub]     CrossRef
• High-concentration Mg2+ stress improves L-lactic acid biosynthesis of Bacillus coagulans revealed by combined analysis of transcriptome and metabolome
  Zhitong Sun, Jiaxin Liang, Gang Wang, Yumeng Zhen, Jinlong Liu, Di Cai, Bin Wang, Yong Wang
  Journal of Biotechnology.2026; 409: 1.     CrossRef
• PDK4 is critical for metabolic regulation and progesterone production in bovine granulosa cells
  Xuelian Tao, Dirk Koczan, Julia Brenmoehl, Jens Vanselow, Vijay Simha Baddela
  Biology of Reproduction.2026; 114(3): 952.     CrossRef
• Targeting PDK4 attenuates neointimal hyperplasia and regulates VSMC phenotypic switching, apoptosis, and autophagy
  Ankan Sarkar, Sakeel Ahmed, Monika Singh, Zahid Bashir Zargar, Sandip V Pawar, Shyam Sunder Sharma, Kanwaljit Chopra, Manish Jain
  Biochemical Pharmacology.2026; 247: 117805.     CrossRef
• Multi-dimensional analysis reveals the potential of PDK4 as a tumor biomarker and target for immunotherapy
  Yaxing Deng, Xin Wang, Mei Zeng, Chenglin Wang
  Discover Oncology.2026;[Epub]     CrossRef
• Research progress on the molecular mechanism and clinical evidence of glucagon-like peptide-1 receptor agonists in improving sarcopenia
  Qun Yang, Yuting Wang, Ge Gao, Haitao Li, Yu Gao, Jianqiu He
  Diabetology & Metabolic Syndrome.2026;[Epub]     CrossRef
• Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials
  Xiaoqin Xu, Xiaoqi Bai, Wei Cao, Danting Fei, Dandan Yang, Xuning Shen, Jun Xu, Dongjun Xu
  Clinics.2026; 81: 100901.     CrossRef
• Mitochondrial ROS dyshomeostasis: a key driver of accelerated supraspinatus atrophy after rotator cuff injury
  Erkai Pang, Yijin Zou, Kongye Lu, Jian Li, Xuxu Chen, Yu Zhu, Tao Wang, Linlin Shi, Hui Kang
  Frontiers in Physiology.2026;[Epub]     CrossRef
• Molecular and Cellular Mechanisms of Sarcopenia: Integrating Fiber‐Type Remodeling, Contractile Protein Dynamics, and Systemic Regulatory Pathways
  Nikam Rutuja Dilesh, Divyansh Khatri, Richa Shrivastava, Sapana Kushwaha
  Cell Biochemistry and Function.2026;[Epub]     CrossRef
• Targeting the activin/myostatin - actrii pathway to preserve skeletal muscle mass in obesity: mechanistic insights and therapeutic perspectives
  Giuseppe Lisco, Anna De Tullio, Olga Eugenia Disoteo, Palma Dicorato, Anna Tortora, Vincenzo De Geronimo, Vincenzo Triggiani
  Reviews in Endocrine and Metabolic Disorders.2026;[Epub]     CrossRef
• Piceatannol-3′-O-β-d-glucopyranoside mitigates myocardial ischemia-reperfusion injury by inhibiting ferroptosis through the regulation of NDUFS1 lactylation via metabolic reprogramming
  Genhao Fan, Chidao Zhang, Wenqing Zhang, Xuli Ji, Menglin Liu, Peng Chen, Boyong Qiu, Yankun Song, Min Zhang, Teng Ma, Zhengwei Dong, Zuoying Xing, Yuhong Huang, Mingjun Zhu, Yongxia Wang
  Redox Biology.2026; 94: 104198.     CrossRef
• The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications
  Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci
  Molecular Nutrition & Food Research.2026;[Epub]     CrossRef
• PDK4 knockdown suppresses osteoclast differentiation in osteoporosis through glycolytic flux suppression and AMPK activation
  Yanling Huang, Rong Zhou, Rulian Liang, Jiping Shen
  Bone.2026; 209: 117911.     CrossRef
• The immunometabolic role of pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis in cardiovascular disease and beyond
  Andrietta Grentzmann, Daniel F J Ketelhuth
  Cardiovascular Research.2026;[Epub]     CrossRef
• Repairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies
  Thomas Lilley, Donny M. Camera, Faith A.A. Kwa
  Drug Discovery Today.2025; 30(1): 104283.     CrossRef
• Could Sarcopenia Be Related to Chemotherapy in Gastrointestinal Cancer? A Cross-Sectional Study Including Comprehensive Geriatric Assessment
  Kamile Sılay, Gökhan Uçar, Tülay Eren, Hande Selvi Öztorun, Ozan Yazıcı, Nuriye Özdemir
  Journal of Clinical Medicine.2025; 14(3): 711.     CrossRef
• The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States
  Jianqiang Zhang, Huifeng Zhang
  Lipids in Health and Disease.2025;[Epub]     CrossRef
• Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
  Hui Bang Cho, Hye‐Ryoung Kim, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Hye Jin Kim, Keun‐Hong Park
  Advanced Science.2025;[Epub]     CrossRef
• The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS)
  Yuting Yang, Yan Wang, Qiao Chen, Ling Li, Wangping Jia
  Brain and Behavior.2025;[Epub]     CrossRef
• Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
  Xiangyuan Meng, Hui Zhang, Zhenhu Zhao, Siyao li, Xin Zhang, Ruihan Guo, Huimin Liu, Yiling Yuan, Wanrui Li, Qi Song, Jinyu Liu
  Molecular Medicine.2025;[Epub]     CrossRef
• Dipalmitoylphosphatidylcholine Lipid Vesicles for Delivering HMB, NMN, and L-Leucine in Sarcopenia Therapy
  Alfred Najm, Alexandra Cătălina Bîrcă, Adelina-Gabriela Niculescu, Adina Alberts, Alexandru Mihai Grumezescu, Bianca Gălățeanu, Bogdan Ștefan Vasile, Mircea Beuran, Bogdan Severus Gaspar, Ariana Hudiță
  Molecules.2025; 30(7): 1437.     CrossRef
• Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4
  Stephanie E. Areloegbe, Chukwubueze L. Atuma, Ayodeji Aturamu, Isaac O. Ajadi, Oluseyi E. Adelekan, Mary B. Ajadi, Christopher O. Akintayo, Gloria O. Omoruyi, Samuel O. Onyekweli, Omosola F. Anifowose, Oluwatobi A. Amusa, Kayode Ajayi, Paul A. Oyewole, To
  BMC Nephrology.2025;[Epub]     CrossRef
• Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia
  Marina Ribas Losasso, Maria Luiza Cesto Parussolo, Antony Oliveira Silva, Rosa Direito, Karina Quesada, Claudia Rucco Penteado Detregiachi, Marcelo Dib Bechara, Nahum Méndez-Sánchez, Ludovico Abenavoli, Adriano Cressoni Araújo, Ricardo de Alvares Goulart,
  International Journal of Molecular Sciences.2025; 26(10): 4673.     CrossRef
• Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation
  Zhaobin Wang, Kunyang Li, Xiaoqi Yi, Yichen Wu, Yang Zhao, Pingping He, Qinghua Zeng, Enxiang Zhang
  Food and Chemical Toxicology.2025; 203: 115592.     CrossRef
• FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis
  Peixuan Wu, Nan Song, Yang Xiang, Zhe Tao, Bing Mao, Ruochen Guo, Xin Wang, Dan Wu, Zhenzhen Zhang, Xin Chen, Duan Ma, Tianyu Zhang, Bingtao Hao, Jing Ma
  EMBO Molecular Medicine.2025; 17(7): 1599.     CrossRef
• Molecular Network Analysis and Effector Gene Prioritization of Endurance-Training-Influenced Modulation of Cardiac Aging
  Mingrui Wang, Samuhaer Azhati, Hangyu Chen, Yanyan Zhang, Lijun Shi
  Genes.2025; 16(7): 814.     CrossRef
• Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine
  Xiangliang Liu, Xinqiao Chen, Jiuwei Cui
  Clinical Nutrition.2025; 51: 187.     CrossRef
• An in vitro model to study molecular pathogenesis of sarcopenia established by a SASP-dependent human myotube culture
  Kiyo-aki Ishii, Ryo Hashimoto, Chikako Umeda, Tohru Hosoyama, Ken Watanabe, Keisuke Hitachi
  PLOS One.2025; 20(7): e0326968.     CrossRef
• Postbiotic Intervention in Sarcopenia: The Role of Lactiplantibacillus plantarum HY7715 and Its Extracellular Vesicles
  Kippeum Lee, Soo Dong Park, Joo Yun Kim, Jae Jung Shim, Jae Hwan Lee
  Life.2025; 15(7): 1101.     CrossRef
• Targeting ALDH2 to promote skeletal muscle health: A novel strategy against mitochondrial dysfunction
  Katia S. G. Andrade, Jianming Liu, Dimitrius Santiago P. S. F. Guimarães, Julio C.B. Ferreira, Zhigao Wang, Da‐Zhi Wang, Leonardo R. Silveira
  The Journal of Physiology.2025; 603(16): 4483.     CrossRef
• Healthy Dietary Patterns and Risk of Sarcopenia in Adults Aged > 50 Years: A Systematic Review and Meta-Analysis Considering EWGSOP1 and EWGSOP2 Criteria
  Roxana E. Ruiz-Valenzuela, Reyes Artacho, María Dolores Ruiz-López, Esther Molina-Montes
  Nutrients.2025; 17(17): 2764.     CrossRef
• The Role of Methylmalonic Acid in the Risk of Sarcopenia and All‐Cause Mortality Among Individuals With Sarcopenia: Evidence From NHANES
  Ping Zhu, Jie Zhang, Xue‐Chun Liu, Ming Song, Bin Lu, Zhi‐Cheng Yang, Hui Pan, Ya‐Qiong Jiao, Ya‐Fei Guo, Fang‐Fang Chen, Zhi‐Hao Wang, Bo‐Ang Hu, Ming Zhong
  Food Science & Nutrition.2025;[Epub]     CrossRef
• Mechanical Stimulation Induces Yap Mediated OCTN2 Transcription to Enhance Carnitine Metabolism in Sarcopenia
  Yahong Lu, Yu Bai, Weiqing Li, Zhiguo Zhou, Heihuan Lai, Xingyu Hu, Tao Yang, Chendi Wang, Yitao Chen, Keping Gan, Kechi Li, Haiwei Ma, Lin Shen, Dengwei He
  Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub]     CrossRef
• Skeletal muscle alterations in type 2 diabetes mellitus with and without dyslipidemia
  Safak Yigit, Busra Ulker Eksi, Ilhan Satman, Damla Korkmaz Dayican, Fulya Calikoglu, Humeyra Rekali Sahin, Francesco Perone, Buket Akinci
  Lipids in Health and Disease.2025;[Epub]     CrossRef
• Targeting mitochondrial transporters and metabolic reprogramming for disease treatment
  Mboneye Anselme, Huafeng He, Chengyang Lai, Wenwei Luo, Shilong Zhong
  Journal of Translational Medicine.2025;[Epub]     CrossRef
• Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health program
  Maryam kheirandish, Neda Cheraghloo, Nafiseh Tavasoli, Farideh Razi, Farima Farsi, Atefeh Amrollahi Bioky, Hamid Reza Aghaei Meybodi, Kazem Khalagi, Ramin Heshmat, Niloufar Najjar, Maryam Amini Shirkouhi, Iraj Nabipour, Gita Shafiee, Bagher Larijani
  Journal of Diabetes & Metabolic Disorders.2025;[Epub]     CrossRef
• The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia
  Aniket S Joshi, Meiricris Tomaz da Silva, Anh Tuan Vuong, Bowen Xu, Ravi K Singh, Ashok Kumar
  EMBO Molecular Medicine.2025; 17(12): 3607.     CrossRef
• Genomic Insights into Bear Hibernation
  Blair W. Perry, Heiko T. Jansen, Alexis N. Enstrom, Joanna L. Kelley
  Annual Review of Genetics .2025; 59(1): 147.     CrossRef
• From mitochondrial dysfunction to frailty and sarcopenia: genetic evidence from multi-omics data via Mendelian randomization and colocalization
  Abudunaibi Wupuer, Xing Peng, Jie Wang, Yihan Li, Kaidiriyan Kuribanjiang, Shikang Yan, Lei Yang, Gustavo Duque
  The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2025;[Epub]     CrossRef
• Recent advances in the research of sarcopenia in colorectal cancer
  Yang Wang, Yuliuming Wang, Ming Liu
  Holistic Integrative Oncology.2025;[Epub]     CrossRef
• Metabolic score for visceral fat as a superior predictor of frailty in overweight and obese adults: a cross-sectional NHANES analysis (2007–2020)
  Yiming Zhan, Jeffrey William Ripley-Gonzalez, Yuhang Liu, Yang Gao, Jialing Tang, Siyao Gao
  Diabetology & Metabolic Syndrome.2025;[Epub]     CrossRef
• PROPHYLACTIC EFFICACY OF GLYCOSIDES RICH STANDARDIZED FENUGREEK SEED EXTRACT ON EXPERIMENTAL RENAL INTERSTITIAL FIBROSIS IN MICE
  PRASAD THAKURDESAI, ROHINI PUJARI
  International Journal of Pharmacy and Pharmaceutical Sciences.2025; : 42.     CrossRef
• Synthesis, activatory effects, molecular docking and ADME studies as rabbit muscle pyruvate kinase activators of ureido phenyl substituted 1,4-dihydropyridine derivatives
  Mustafa Oğuzhan Kaya, Tuna Demirci, Ümit Çalışır, Oğuzhan Özdemir, Yeşim Kaya, Mustafa Arslan
  Research on Chemical Intermediates.2024; 50(1): 437.     CrossRef
• Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction
  Yanmei Miao, Leiyu Xie, Jiamei Song, Xing Cai, Jinghe Yang, Xinglong Ma, Shaolin Chen, Peng Xie
  Physiological Reports.2024;[Epub]     CrossRef
• Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
  Zonghao Qian, Yuzhen Huang, Yucong Zhang, Ni Yang, Ziwei Fang, Cuntai Zhang, Le Zhang
  Frontiers in Genetics.2024;[Epub]     CrossRef
• Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation
  Tangtian Chen, Qiumin Xie, Bin Tan, Qin Yi, Han Xiang, Rui Wang, Qin Zhou, Bolin He, Jie Tian, Jing Zhu, Hao Xu
  Inflammation.2024; 47(4): 1356.     CrossRef
• Effect of resistance training plus enriched probiotic supplement on sestrin2, oxidative stress, and mitophagy markers in elderly male Wistar rats
  Majid Mohabbat, Hamid Arazi
  Scientific Reports.2024;[Epub]     CrossRef
• Comparison between single-muscle evaluation and cross-sectional area muscle evaluation for predicting the prognosis in patients with oral squamous cell carcinoma: a retrospective cohort study
  Hirotaka Takayama, Takuya Yoshimura, Hajime Suzuki, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasunori Nakamura, Yasushi Imamura, Akio Inui, Norifumi Nakamura
  Frontiers in Oncology.2024;[Epub]     CrossRef
• Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia
  Cristina Russo, Maria Stella Valle, Floriana D’Angeli, Sofia Surdo, Lucia Malaguarnera
  International Journal of Molecular Sciences.2024; 25(14): 7503.     CrossRef
• Unveiling the crucial role of peroxisomal acyl-CoA metabolism in muscle atrophy: Insights from genetic models and therapeutic interventions
  Songling Jiang, Han Sol Kim, Ji Hyun Ryu, Yong-Soo Lee, Dong-Ik Kim, Eun-Jung Jin
  Nano Today.2024; 58: 102417.     CrossRef
• Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3
  Xuliang Huang, Yuhao Zheng, Nan Wang, Mingming Zhao, Jinhui Liu, Wen Lin, Ye Zhu, Xiaofan Xie, Ya Lv, Junlu Wang, Yunchang Mo
  Inflammation.2024; 48(3): 1159.     CrossRef
• The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue
  Ester Sara Di Filippo, Sara Chiappalupi, Stefano Falone, Vincenza Dolo, Fernanda Amicarelli, Silvia Marchianò, Adriana Carino, Gabriele Mascetti, Giovanni Valentini, Sara Piccirillo, Michele Balsamo, Marco Vukich, Stefano Fiorucci, Guglielmo Sorci, Stefan
  npj Microgravity.2024;[Epub]     CrossRef
• Mitochondria in skeletal system-related diseases
  Liang Pei, Zhuo Yao, Dong Liang, Keda Yang, Lin Tao
  Biomedicine & Pharmacotherapy.2024; 181: 117505.     CrossRef
• Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia
  Raniah I. Alnaser, Fawaz A. Alassaf, Mohammed N. Abed
  Journal of Bone Metabolism.2024; 31(4): 251.     CrossRef
• Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
  Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon
  Biomedicines.2024; 12(12): 2815.     CrossRef
• Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases
  Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao
  International Journal of Nanomedicine.2023; Volume 18: 7559.     CrossRef

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to acetyl-CoA. Tight control of PDC is critical because it plays a key role in glucose disposal. PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns, kinetic properties, and sensitivities to regulatory molecules. During the last decades, the up-regulation of PDKs has been observed in the tissues of patients and mammals with metabolic diseases, which suggests that the inhibition of these kinases may have beneficial effects for treating metabolic diseases. This review summarizes the recent advances in the role of specific PDK isoenzymes on the induction of metabolic diseases and describes the effects of PDK inhibition on the prevention of metabolic diseases using pharmacological inhibitors. Based on these reports, PDK isoenzymes are strong therapeutic targets for preventing and treating metabolic diseases.

Citations

Citations to this article as recorded by  

• Coordination of Glucose and Glutamine Metabolism in Tendon Is Lost in Aging
  Samuel J. Mlawer, Felicia R. Pinto, Katie J. Sikes, Brianne K. Connizzo
  Journal of Orthopaedic Research.2026;[Epub]     CrossRef
• Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer
  Mulchand S. Patel, Todd C. Rideout
  International Journal of Cancer.2026; 158(6): 1464.     CrossRef
• Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer
  Yan Ye, Zuli Ou, Canling Li, Qingyu Liao, Qian Zeng, Xiaoqian Ju, Dian Zhang, Yu Wei, Xiang Zhang, Tao Zhang, Kejia Wu
  Cancer Science.2026; 117(2): 335.     CrossRef
• Mitochondrial pyruvate dehydrogenase kinase 1 drives bevacizumab resistance and malignant phenotype of TNBC by enhancing mitophagy
  Yan Ye, Qian Zeng, Zuli Ou, Xiaoqian Ju, Qingyu Liao, Canling Li, Dian Zhang, Yu Wei, Xiang Zhang, Kejia Wu, Tingmei Chen
  Pharmacological Research.2026; 224: 108081.     CrossRef
• NF-κB activation as a pro-survival signal from pharmacological inhibition of pyruvate dehydrogenase kinase 1 in non-small-cell lung carcinoma cell models
  Quan Liu, Maoxin Ran, Wenying Shan, Shao-Lin Zhang, Kin Yip Tam
  Translational Oncology.2026; 65: 102681.     CrossRef
• Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions
  Zhi He, Jie Diao, Frederick G. Hamel, Bin Duan
  Bioactive Materials.2026; 61: 312.     CrossRef
• Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption
  Sifan Xu, Na Xu, Hongbao Fang, Zhirong Zhu, Yan Su, Zhi Su
  Journal of Inorganic Biochemistry.2026; 280: 113317.     CrossRef
• Drugging non-canonical kinases in cancer therapeutics: Molecular targets, underlying mechanisms and small-molecule inhibitors
  Xuelan Ma, Zhifeng Wen, Zhiwen Wang, Zhiqi Peng, Dongbo Wu, Jun Wang, Bo Liu
  Acta Pharmaceutica Sinica B.2026;[Epub]     CrossRef
• Pharmacological Inhibition of Pyruvate Dehydrogenase Kinase 4 Enhances Insulin Sensitivity in Mouse Models of Diabetes and Obesity
  Min-Ji Kim, Bitna Ha, Ran Ryeong Kim, Jung-Yi Lee, Chae Won Lim, Jin Hee Ahn, In-Kyu Lee, Jae-Han Jeon
  Journal of Obesity & Metabolic Syndrome.2026; 35(2): 247.     CrossRef
• Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration
  Xiangli Zhang, Pengfei Du, Ziyang Wang, Yao Zhu, Xuemeng Si, Wen Chen, Yanqun Huang
  Poultry Science.2025; 104(1): 104619.     CrossRef
• Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis
  Chen Wang, Cheng Ma, Yuanyou Xu, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Xiakun Chu, Haichun Gao, Xing Zhang, Yunjie Chang
  Nature Communications.2025;[Epub]     CrossRef
• A review of cutting-edge biomarkers for diagnosing coronary artery disease
  Pouria Azami, Sahand Mohammadzadeh, Soroush Seirafi, Iman Razeghian-Jahromi
  Medicine.2025; 104(4): e41377.     CrossRef
• Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase
  Mya D. Gough, Matthew B. Robers, Cesear R. Corona, Ranjit K. Mehta, Mukesh K. Nyati, Peter L. Toogood
  SLAS Discovery.2025; 32: 100227.     CrossRef
• Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications
  Archee Panwar, Sufyan O. Malik, Muhtasim Adib, Gary D. Lopaschuk
  American Journal of Physiology-Heart and Circulatory Physiology.2025; 328(5): H1089.     CrossRef
• Lactate-mediated metabolic reprogramming of tumor-associated macrophages: implications for tumor progression and therapeutic potential
  Xiaohan Jin, Ni Zhang, Tinghao Yan, Jingyang Wei, Lingli Hao, Changgang Sun, Haibo Zhao, Shulong Jiang
  Frontiers in Immunology.2025;[Epub]     CrossRef
• Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism
  Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li
  Antioxidants.2025; 14(5): 603.     CrossRef
• PDK1-dependent metabolic reprogramming regulates stemness and tumorigenicity of osteosarcoma stem cells through ATF3
  Kazuya Tokumura, Kazuya Fukasawa, Jiro Ichikawa, Koki Sadamori, Manami Hiraiwa, Eiichi Hinoi
  Cell Death & Disease.2025;[Epub]     CrossRef
• Structural diversity of pyruvate dehydrogenase complexes
  Sarah N. Bothe, Rafal Zdanowicz
  FEBS Letters.2025;[Epub]     CrossRef
• PDHA1-mediated H3K18 lactylation is involved in arsenic-induced nonalcoholic fatty liver disease by activating the CD36–NLRP3 inflammasome axis
  Han Li, Zhenyang Li, Lin Chen, Xiaoshan Peng, Dapeng Wang, Qian Sun, Yuting Chen, Aihua Zhang, Qizhan Liu, Huanwen Tang
  Journal of Hazardous Materials.2025; 498: 139852.     CrossRef
• The cancer-induced lactate load and oncologic remodeling hypothesis: lactate as a driver of biosynthesis and epigenetics in cancer
  Hüseyin Aydin
  Frontiers in Oncology.2025;[Epub]     CrossRef
• BACH1 promotes hepatocellular carcinoma progression by targeting PDP1 towards the PI3K-AKT-mTOR signaling activation
  Qiqi Bu, Xiaojing Qi, Qing Wang, Shujuan Liu, Shanshan Lin, Zhanhang Wang, Yiguo Zhang
  Bioorganic Chemistry.2025; 166: 109188.     CrossRef
• Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds
  Yi Zhao, Wenxiu Hu, Xinnan Wang, Zhiyue Ren, Yumeng Gong, Lu Liu, Youzhi Sun
  International Journal of Molecular Sciences.2025; 26(24): 11970.     CrossRef
• MetaboLM: a metabolomic language model for multi-disease early prediction and risk stratification
  Shizheng Qiu, Jirui Guo, Zhishuai Zhang, Haozheng Liang, Huanyu You, Yang Hu, Guiyou Liu, Yadong Wang
  Nature Communications.2025;[Epub]     CrossRef
• Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
  Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu
  The Journal of Infectious Diseases.2024; 229(4): 1178.     CrossRef
• Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria
  Konstantin S. Plokhikh, Semen V. Nesterov, Yuriy M. Chesnokov, Anton G. Rogov, Roman A. Kamyshinsky, Aleksandr L. Vasiliev, Lev S. Yaguzhinsky, Raif G. Vasilov
  The FEBS Journal.2024; 291(1): 132.     CrossRef
• Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
  Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha
  International Journal of Molecular Sciences.2024; 25(2): 807.     CrossRef
• Gamut of glycolytic enzymes in vascular smooth muscle cell proliferation: Implications for vascular proliferative diseases
  Ankan Sarkar, Sandip V. Pawar, Kanwaljit Chopra, Manish Jain
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(3): 167021.     CrossRef
• Recent advances in pyruvate dehydrogenase kinase inhibitors: Structures, inhibitory mechanisms and biological activities
  Yiyang Li, Zhizhong Xie, Xiaoyong Lei, Xiaoyan Yang, Sheng Huang, Weixi Yuan, Xiangping Deng, Zhe Wang, Guotao Tang
  Bioorganic Chemistry.2024; 144: 107160.     CrossRef
• Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments
  Jianda Yue, Jiawei Xu, Yekui Yin, Yuanyuan Shu, Yaqi Li, Tingting Li, Zirui Zou, Zihan Wang, Fengjiao Li, Mengqi Zhang, Songping Liang, Xiao He, Zhonghua Liu, Ying Wang
  International Journal of Biological Macromolecules.2024; 262: 129970.     CrossRef
• Metabolic regulation of skeletal cell fate and function
  Steve Stegen, Geert Carmeliet
  Nature Reviews Endocrinology.2024; 20(7): 399.     CrossRef
• Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer
  Wonyoung Park, Shibo Wei, Chu-Long Xie, Jung Ho Han, Bo-Sung Kim, Bosung Kim, Jung-Sook Jin, Eun-Sun Yang, Min Kyoung Cho, Dongryeol Ryu, Hao-Xian Yang, Sung-Jin Bae, Ki-Tae Ha
  Experimental & Molecular Medicine.2024; 56(5): 1137.     CrossRef
• Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase
  Masafumi Inoue, Hironobu Nagamori, Toru Morita, Satoru Kobayashi, Koichi Suzawa, Yuki Kitao, Tomoyuki Saito, Iichiro Kawahara, Takuya Orita, Shota Akai, Tsuyoshi Adachi, Takahisa Motomura
  Bioorganic & Medicinal Chemistry Letters.2024; 109: 129839.     CrossRef
• Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
  Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
  Diabetes & Metabolism Journal.2024; 48(3): 405.     CrossRef
• Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads
  Yuejiao Wang, Xue Wang, Chaoqi Du, Zeming Wang, Jiahui Wang, Nan Zhou, Baohua Wang, Ke Tan, Yumei Fan, Pengxiu Cao
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Research into how carvacrol and metformin affect several human proteins in a hyperglycemic condition: A comparative study in silico and in vitro
  Nail Besli, Nilufer Ercin, Miguel Carmena-Bargueño, Bahar Sarikamis, Rabia Kalkan Cakmak, Guven Yenmis, Horacio Pérez-Sánchez, Merve Beker, Ulkan Kilic
  Archives of Biochemistry and Biophysics.2024; 758: 110062.     CrossRef
• Glycolysis, the sweet appetite of the tumor microenvironment
  Zeinab Kooshan, Lilibeth Cárdenas-Piedra, Judith Clements, Jyotsna Batra
  Cancer Letters.2024; 600: 217156.     CrossRef
• Anaerobic Glycolysis and Ischemic Stroke: From Mechanisms and Signaling Pathways to Natural Product Therapy
  Jia Pu, Jin Han, Jiehong Yang, Li Yu, Haitong Wan
  ACS Chemical Neuroscience.2024; 15(17): 3090.     CrossRef
• Effective strategies alleviate mitochondrial toxicity of perfluorooctanoic acid: Modification of functional head group and inhibition of toxic target
  Ruijia Zhang, Lanyin Tu, Yingshi Lin, Jiahui Liu, Tong Liang, Wenhua Lu, Baowei Chen, Tiangang Luan
  Journal of Hazardous Materials.2024; 479: 135733.     CrossRef
• MicroRNA-382 as a tumor suppressor during tumor progression
  Yalda Samsami, Iman Akhlaghipour, Negin Taghehchian, Mahsa Palizkaran Yazdi, Saba Farrokhi, Hamid Reza Rahimi, Meysam Moghbeli
  Bioorganic & Medicinal Chemistry Letters.2024; 113: 129967.     CrossRef
• The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
  Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao
  Frontiers in Bioscience-Landmark.2024;[Epub]     CrossRef
• Identifying selective PDHK inhibitors using coupled tensor matrix completion and experimental validation
  Flora Rajaei, Peter Toogood, Renju Jacob, Mason Baber, Mya Gough, Harm Derksen, Emily Wittrup, Kayvan Najarian
  Discover Artificial Intelligence.2024;[Epub]     CrossRef
• Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
  Hui-fang Zhang, Hui-ming Liu, Jia-yi Xiang, Xing-cheng Zhou, Dan Wang, Rong-yu Chen, Wan-lin Tan, Lu-qun Liang, Ling-ling Liu, Ming-jun Shi, Fan Zhang, Ying Xiao, Yu-xia Zhou, Tian Zhang, Lei Tang, Bing Guo, Yuan-yuan Wang
  Acta Pharmacologica Sinica.2023; 44(5): 1051.     CrossRef
• Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer
  Weijing He, Qingguo Li, Xinxiang Li
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(1): 188837.     CrossRef
• Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3
  Kehinde S. Olaniyi, Stephanie E. Areloegbe
  Nutrition.2023; 107: 111914.     CrossRef
• Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines
  Lijun Gong, Fang Wei, Frank J. Gonzalez, Guolin Li
  Hepatology.2023; 78(5): 1625.     CrossRef
• The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
  Peter W. Stacpoole, Charles E. McCall
  Mitochondrion.2023; 70: 59.     CrossRef
• Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors
  Deniz Arslan, Matthieu Schoumacher, Sébastien Dilly, Benaïssa Elmoualij, Danièle Zorzi, Pascale Quatresooz, Vincent Lambert, Agnès Noël, Bernard Pirotte, Pascal de Tullio
  Medicinal Chemistry.2023; 19(3): 276.     CrossRef
• AP2α negatively regulates PDHA1 in cervical cancer cells to promote aggressive features and aerobic glycolysis in vitro and in vivo
  Lijie Zhao, Rong Geng, Yi Huang, Jiping Zhang, Haiying Cheng, Cankun Zhou, Yifeng Wang
  Journal of Gynecologic Oncology.2023;[Epub]     CrossRef
• Pyruvate dehydrogenase kinase inhibitor dichloroacetate augments autophagy mediated constraining the replication of Mycobacteroides massiliense in macrophages
  Hailian Quan, Hyewon Chung, Sungmo Je, Jung Joo Hong, Bum-Joon Kim, Yi Rang Na, Seung Hyeok Seok
  Microbes and Infection.2023; 25(7): 105139.     CrossRef
• Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
  Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan
  Blood Advances.2023; 7(11): 2347.     CrossRef
• Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue
  Zhi-Hong Wen, Chun-Sung Sung, Sung-Chun Lin, Zhi-Kang Yao, Yu-Cheng Lai, Yu-Wei Liu, Yu-Yan Wu, Hsi-Wen Sun, Hsin-Tzu Liu, Wu-Fu Chen, Yen-Hsuan Jean
  International Journal of Molecular Sciences.2023; 24(13): 10770.     CrossRef
• TUG1 protects against ferroptosis of hepatic stellate cells by upregulating PDK4-mediated glycolysis
  Xiangting Zhang, Luying Zhao, Kanglei Ying, Jun Xu, Yangjin Huang, Ruhuang Zhu, Yinrong Ding, Weimin Cai, Xiao Wu, Dan Miao, Qian Xu, Yuan Zeng, Fujun Yu
  Chemico-Biological Interactions.2023; 383: 110673.     CrossRef
• Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
  Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
  Cell Death & Disease.2023;[Epub]     CrossRef
• Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
  Chenyu Li, Chuanbin Liu, Junfeng Zhang, Yanyu Lu, Bingtong Jiang, Huabao Xiong, Chunxia Li
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Implications of tempol in pyruvate dehydrogenase kinase 3 targeted anticancer therapeutics: Computational, spectroscopic, and calorimetric studies
  Saleha Anwar, Debarati DasGupta, Alaa Shafie, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Moyad Shahwan, Farah Anjum, Waleed Al Abdulmonem, Sharaf E. Sharaf, Md. Imtaiyaz Hassan
  Journal of Molecular Liquids.2022; 350: 118581.     CrossRef
• Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect
  Mohamed A. Nassan, Adil Aldhahrani, Hamada H. Amer, Ahmed Elhenawy, Ayman A. Swelum, Omar M. Ali, Yasser H. Zaki
  Molecules.2022; 27(3): 756.     CrossRef
• An enzyme-responsive and NIR-triggered lipid–polymer hybrid nanoplatform for synergistic photothermal/chemo cancer therapy
  Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
  Biomaterials Science.2022; 10(9): 2370.     CrossRef
• BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway
  Huashun Li, Dongyang Yu, Lianbing Li, Juanjuan Xiao, Yijian Zhu, Yi Liu, Li Mou, Yafei Tian, Linbo Chen, Feng Zhu, Qiuhong Duan, Peipei Xue, Dali Zheng
  Journal of Oncology.2022; 2022: 1.     CrossRef
• Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
  Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
  Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
• Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs
  Fereydoon Abedi-Gaballu, Elham Kamal Kazemi, Seyed Ahmad Salehzadeh, Behnaz Mansoori, Farhad Eslami, Ali Emami, Gholamreza Dehghan, Behzad Baradaran, Behzad Mansoori, William C. Cho
  Cells.2022; 11(19): 2973.     CrossRef
• PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level
  Yan Song, Juan Zhang, Lei Zhang, Suxia Zhang, Chengcheng Shen, Jincheng Wang
  Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
• Changes in the Expression of Pyruvate Dehydrogenase Kinase Isoenzymes During Early Differentiation of Mouse Embryonic Stem Cells
  Saime GÜZEL
  Journal of Research in Veterinary Medicine.2022; 41(2): 92.     CrossRef
• Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation
  Sunil Poudel, Gil Martins, M. Leonor Cancela, Paulo J. Gavaia
  International Journal of Molecular Sciences.2022; 23(23): 15160.     CrossRef
• Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer
  Taj Mohammad, Kaynat Arif, Mohamed F. Alajmi, Afzal Hussain, Asimul Islam, Md. Tabish Rehman, Imtaiyaz Hassan
  Journal of Biomolecular Structure and Dynamics.2021; 39(2): 586.     CrossRef
• Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
  Russel J. Reiter, Ramaswamy Sharma, Sergio Rosales-Corral
  International Journal of Molecular Sciences.2021; 22(2): 764.     CrossRef
• BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
  Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
  Developmental Cell.2021; 56(8): 1182.     CrossRef
• Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
  Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li
  Bioscience Reports.2021;[Epub]     CrossRef
• Identification of differentially expressed genes and the role of PDK4 in CD14+ monocytes of coronary artery disease
  Pei Du, Ren Guo, Keqin Gao, Shuang Yang, Baige Yao, Haobo Cui, Ming Zhao, Sujie Jia
  Bioscience Reports.2021;[Epub]     CrossRef
• Radiation-Induced Metabolic Shifts in the Hepatic Parenchyma: Findings from 18F-FDG PET Imaging and Tissue NMR Metabolomics in a Mouse Model for Hepatocellular Carcinoma
  Yi-Hsiu Chung, Cheng-Kun Tsai, Ching-Fang Yu, Wan-Ling Wang, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen, Gigin Lin
  Molecules.2021; 26(9): 2573.     CrossRef
• Long non-coding RNA AFAP1-AS1 facilitates ovarian cancer progression by regulating the miR-107/PDK4 axis
  Bao Liu, Li Yan, Yugang Chi, Yuhan Sun, Xiaoyu Yang
  Journal of Ovarian Research.2021;[Epub]     CrossRef
• Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
  Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568.     CrossRef
• Metabolic Alterations in Sepsis
  Weronika Wasyluk, Agnieszka Zwolak
  Journal of Clinical Medicine.2021; 10(11): 2412.     CrossRef
• Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex
  Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao, Chenji Wang
  Cell Death & Disease.2021;[Epub]     CrossRef
• circ_0005962 functions as an oncogene to aggravate NSCLC progression
  Zhihong Zhang, Zhenxiu Shan, Rubin Chen, Xiaorong Peng, Bin Xu, Liang Xiao, Guofei Zhang
  Open Medicine.2021; 16(1): 997.     CrossRef
• Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways
  Yu Liu, Yan-Qing Li, Shi-Hao Huang, Yong-Long Li, Jia-Wei Xia, Jun-Shuang Jia, Fang Wei, Jia-Hong Wang, Guan-Qi Dai, Yu-Cai Wang, Xiao-Yan Li, Liu-Xin Han, Xiao-Ling Zhang, Xu-Dong Xiang, Wen-Tao Zhao, Dong Xiao, Xiao-Lin Lin
  Aging.2021; 13(17): 21155.     CrossRef
• Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis
  Yihong Huang, Shuo Zheng, Ying Lin, Liming Ke
  Molecular and Cellular Biology.2021;[Epub]     CrossRef
• Odontogenic gene expression profile of human dental pulp-derived cells under high glucose influence: a microarray analysis
  Sivaporn HORSOPHONPHONG, Hathaitip SRITANAUDOMCHAI, Siriruk NAKORNCHAI, Nakarin KITKUMTHORN, Rudee SURARIT
  Journal of Applied Oral Science.2021;[Epub]     CrossRef
• Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
  I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva
  Cellular and Molecular Life Sciences.2021; 78(23): 7451.     CrossRef
• Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells
  Ling Jin, Minkyoung Cho, Bo-Sung Kim, Jung Ho Han, Sungmi Park, In-Kyu Lee, Dongryeol Ryu, Jae Ho Kim, Sung-Jin Bae, Ki-Tae Ha
  BMB Reports.2021; 54(11): 563.     CrossRef
• Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area
  Giovanni Tulipano
  International Journal of Molecular Sciences.2021; 22(23): 13068.     CrossRef
• Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
  Choong-Hwan Kwak, Ling Jin, Jung Ho Han, Chang Woo Han, Eonmi Kim, MyoungLae Cho, Tae-Wook Chung, Sung-Jin Bae, Se Bok Jang, Ki-Tae Ha
  International Journal of Molecular Sciences.2020; 21(17): 6021.     CrossRef
• Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy
  Chung-Yu Huang, Li-Han Hsu, Chung-Yeh Chen, Gee-Chen Chang, Hui-Wen Chang, Yi-Mei Hung, Ko-Jiunn Liu, Shu-Huei Kao
  Cancers.2020; 12(1): 181.     CrossRef
• Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
  Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
  Molecular Medicine Reports.2020;[Epub]     CrossRef
• STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
  Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger, Jan Pencik, Petra Kodajova, Sandra Högler, Georg Stockmaier, Sandra Grund‐Gröschk
  Molecular Systems Biology.2020;[Epub]     CrossRef
• Differential effects of metformin on reductive activity and energy production in pituitary tumor cells compared to myogenic precursors
  Giovanni Tulipano, Simone Paghera, Cristina Missale, Andrea Giustina
  Endocrine.2020; 69(3): 604.     CrossRef
• Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
  Xiqiong Han, Wenqi Ma, Yi Zhu, Xuejiao Sun, Naifeng Liu
  Molecular and Cellular Endocrinology.2020; 514: 110878.     CrossRef
• Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells
  Giovanni Tulipano, Andrea Giustina
  Pituitary.2020; 23(3): 223.     CrossRef
• Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
  Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
  Cancer & Metabolism.2020;[Epub]     CrossRef
• miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer
  Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li
  Molecular Therapy - Oncolytics.2020; 17: 509.     CrossRef
• Bayesian variable selection for high dimensional predictors and self-reported outcomes
  Xiangdong Gu, Mahlet G Tadesse, Andrea S Foulkes, Yunsheng Ma, Raji Balasubramanian
  BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
• Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?
  Jordy M. M. Kocken, Paula A. da Costa Martins
  International Journal of Molecular Sciences.2020; 21(23): 8901.     CrossRef
• Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
  Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha
  Scientific Reports.2020;[Epub]     CrossRef
• Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
  Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Ri
  eLife.2019;[Epub]     CrossRef
• Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
  Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
  Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
• Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
  Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo
  European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
• Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
  Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
• Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells
  Rokibul Islam, Jae-Gyu Kim, Yohan Park, Jung-Yoon Cho, Kim-Cuong Cap, A-Ra Kho, Won-Suk Chung, Sang-Won Suh, Jae-Bong Park
  The FASEB Journal.2019; 33(2): 2072.     CrossRef
• ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts
  Tatsufumi Goto, Kumi Ubukawa, Isuzu Kobayashi, Kotomi Sugawara, Ken Asanuma, Yumi Sasaki, Yong-Mei Guo, Naoto Takahashi, Kenichi Sawada, Hideki Wakui, Wataru Nunomura
  Experimental Hematology.2019; 72: 14.     CrossRef
• Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity
  Choong-Hwan Kwak, Jung-Hee Lee, Eun-Yeong Kim, Chang Woo Han, Keuk-Jun Kim, Hanna Lee, MyoungLae Cho, Se Bok Jang, Cheorl-Ho Kim, Tae-Wook Chung, Ki-Tae Ha
  Cancers.2019; 11(5): 712.     CrossRef
• Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server
  Andreia S.P. Pereira, Helena den Haan, Jorge Peña-García, Marién M. Moreno, Horacio Pérez-Sánchez, Zeno Apostolides
  Molecules.2019; 24(10): 2002.     CrossRef
• Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
  Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez, Zeno Apostolides
  Molecules.2019; 24(22): 4030.     CrossRef
• Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
  Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
  Cells.2019; 8(11): 1449.     CrossRef
• Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
  Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
  Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
• Molecular interactions underpinning the phenotype of hibernation in mammals
  Matthew T. Andrews
  Journal of Experimental Biology.2019;[Epub]     CrossRef
• Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma
  Surangkana Sanmai, Tanakorn Proungvitaya, Temduang Limpaiboon, Daraporn Chua‑On, Wunchana Seubwai, Sittiruk Roytrakul, Sopit Wongkham, Chaisiri Wongkham, Ongart Somintara, Sakkarn Sangkhamanon, Siriporn Proungvitaya
  Oncology Letters.2019;[Epub]     CrossRef
• Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells
  Li Xie, Junqing Miao, Xiangchao Li, Xiaoping Yi, Ju Chu
  RSC Advances.2019; 9(61): 35760.     CrossRef
• Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
  F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
  Oncogene.2018; 37(8): 1062.     CrossRef
• Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
  Lise Van Wyngene, Jolien Vandewalle, Claude Libert
  EMBO Molecular Medicine.2018;[Epub]     CrossRef
• Effects of β-caryophyllene on arginine ADP-ribosyltransferase 1-mediated regulation of glycolysis in colorectal cancer under high-glucose conditions
  Li Zhou, Mu-Lu Zhan, Yi Tang, Ming Xiao, Ming Li, Qing-Shu Li, Lian Yang, Xian Li, Wen-Wen Chen, Ya-Lan Wang
  International Journal of Oncology.2018;[Epub]     CrossRef
• PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
  Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
  Diabetes.2018; 67(10): 2054.     CrossRef
• Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer
  Bojana Ristic, Yangzom D. Bhutia, Vadivel Ganapathy
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(1): 246.     CrossRef
• Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
  Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
  Oncotarget.2017; 8(68): 112841.     CrossRef
• Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth
  Tae-Wook Chung, Jung Hee Lee, Hee-Jung Choi, Mi-Ju Park, Eun-Yeong Kim, Jung Ho Han, Se Bok Jang, Syng-Ook Lee, Sang Woo Lee, Jin Hang, Li Wan Yi, Ki-Tae Ha
  Journal of Ethnopharmacology.2017; 203: 47.     CrossRef
• Spatial Organization of Metabolic Enzyme Complexes in Cells
  Danielle L. Schmitt, Songon An
  Biochemistry.2017; 56(25): 3184.     CrossRef
• Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells
  Wenjia Zhang, Jing Su, Huadan Xu, Shanshan Yu, Yanan Liu, Yong Zhang, Liankun Sun, Ying Yue, Xiaoli Zhou, Aamir Ahmad
  PLOS ONE.2017; 12(6): e0179672.     CrossRef
• Metabonomic Strategy for the Evaluation of Chinese Medicine Salvia miltiorrhiza and Dalbergia odorifera Interfering with Myocardial Ischemia/Reperfusion Injury in Rats
  Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
  Rejuvenation Research.2017; 20(4): 263.     CrossRef
• Regulation of pyruvate dehydrogenase (PDH) in the hibernating ground squirrel, ( Ictidomys tridecemlineatus )
  Sanoji Wijenayake, Shannon N. Tessier, Kenneth B. Storey
  Journal of Thermal Biology.2017; 69: 199.     CrossRef
• Nuclear localization of metabolic enzymes in immunity and metastasis
  Yuchen He, Menghui Gao, Yiqu Cao, Haosheng Tang, Shuang Liu, Yongguang Tao
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(2): 359.     CrossRef
• The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism
  Ewa Jablonska, Edyta Reszka, Jolanta Gromadzinska, Edyta Wieczorek, Magdalena Krol, Sara Raimondi, Katarzyna Socha, Maria Borawska, Wojciech Wasowicz
  Nutrients.2016; 8(12): 772.     CrossRef
• Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
  Jaechan Leem, In-Kyu Lee
  Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
• Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
  Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
  Scientific Reports.2016;[Epub]     CrossRef
• Drugs that Affect Cardiac Metabolism: Focus on Perhexiline
  Cher-Rin Chong, Benedetta Sallustio, John D. Horowitz
  Cardiovascular Drugs and Therapy.2016; 30(4): 399.     CrossRef
• Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
  Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
  International Journal of Molecular Sciences.2016; 17(3): 340.     CrossRef
• Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
  Camille Lehuédé, Fanny Dupuy, Rebecca Rabinovitch, Russell G. Jones, Peter M. Siegel
  Cancer Research.2016; 76(18): 5201.     CrossRef

In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In the fasted state a relatively low activity of the PDC helps maintain blood glucose levels by conserving pyruvate and other three carbon compounds for gluconeogenesis. The relative activities of the pyruvate dehydrogenase kinases (PDKs) and the opposing pyruvate dehydrogenase phosphatases determine the activity of PDC in the fed and fasted states. Up regulation of PDK4 is largely responsible for inactivation of PDC in the fasted state. PDK4 knockout mice have lower fasting blood glucose levels than wild type mice, proving that up regulation of PDK4 is important for normal glucose homeostasis. In type 2 diabetes, up regulation of PDK4 also inactivates PDC, which promotes gluconeogenesis and thereby contributes to the hyperglycemia characteristic of this disease. When fed a high fat diet, wild type mice develop fasting hyperglycemia but PDK4 knockout mice remain euglycemic, proving that up regulation of PDK4 contributes to hyperglycemia in diabetes. These finding suggest PDK4 inhibitors might prove useful in the treatment of type 2 diabetes.

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Citations to this article as recorded by  

• PDK4 is critical for metabolic regulation and progesterone production in bovine granulosa cells
  Xuelian Tao, Dirk Koczan, Julia Brenmoehl, Jens Vanselow, Vijay Simha Baddela
  Biology of Reproduction.2026; 114(3): 952.     CrossRef
• Androgen deprivation induces distinct muscle-specific transcriptional changes to genes regulating glucose, lipid, and amino acid metabolism
  Wayne A. Ayers-Creech, Jennifer L. Steiner, Grant R. Laskin, Bradley S. Gordon
  Molecular and Cellular Endocrinology.2026; 612: 112704.     CrossRef
• Functional analysis of glucocorticoid treatment associated astrocyte-proteins
  Chuin Hau Teo, Liau Ze Huai, Ishwar S. Parhar, Tomoko Soga
  Neuroscience.2026; 595: 50.     CrossRef
• Diabetic ketoacidosis is not a simple consequence of hyperglycemia, it is biochemical event driven by PDK4-mediated inhibition of PDC
  Ayah Al-Qasrawi
  Medical Hypotheses.2026; 208: 111898.     CrossRef
• Systems Biology Approach to Unraveling Transcriptomic Mechanisms of Ganfule Capsules in Ameliorating Nonalcoholic Fatty Liver Disease
  Yu Pan, Yunkun Zhang, Suren R. Sooranna, Xiaonan Yang, Yaqin Zhou, Lu Chen, Fei Xu, Danna Huang
  Combinatorial Chemistry & High Throughput Screening.2026; 29(2): 207.     CrossRef
• Liver transcriptome dynamics in Holstein cows during the periparturient transition
  Nayan Bhowmik, Mariana da Silva, Alejandro Castaneda, Asha M. Miles, Congjun Li, Curtis P. Van Tassell, Ransom L. Baldwin, J. Eduardo Rico, George E. Liu
  Scientific Reports.2026;[Epub]     CrossRef
• The immunometabolic role of pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis in cardiovascular disease and beyond
  Andrietta Grentzmann, Daniel F J Ketelhuth
  Cardiovascular Research.2026;[Epub]     CrossRef
• Metabolic Flexibility Following High-Intensity Interval Exercise in Active Females: Effect of Feeding State
  Maryam Ebrahimi
  Pamukkale Journal of Sport Sciences.2025; 16(2): 387.     CrossRef
• Acute Cold Exposure Improves Glucose Tolerance and Induces Beta-Cell Secretion Response Linked to Lipid Utilization in Young Male with Obesity
  Rodrigo Chamorro, Beatrice Bertozzi, Jenny Backhaus, Karl A Iwen, Leonie Rademacher, Svenja Meyhoefer, Hendrik Lehnert, Sebastian M Meyhöfer, Britta Wilms
  Experimental and Clinical Endocrinology & Diabetes.2025; 133(12): 532.     CrossRef
• Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women
  Zhaleh Pashaei, Abbas Malandish, Shahriar Alipour, Afshar Jafari, Ismail Laher, Anthony C. Hackney, Katsuhiko Suzuki, Urs Granacher, Ayoub Saeidi, Hassane Zouhal
  BMC Sports Science, Medicine and Rehabilitation.2024;[Epub]     CrossRef
• The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse
  Michael S. Dodd, Lucy Ambrose, Vicky Ball, Kieran Clarke, Carolyn A. Carr, Damian J. Tyler
  Atherosclerosis.2024; 399: 118599.     CrossRef
• Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines
  Lijun Gong, Fang Wei, Frank J. Gonzalez, Guolin Li
  Hepatology.2023; 78(5): 1625.     CrossRef
• microRNA-15b-5p shuttled by mesenchymal stem cell-derived extracellular vesicles protects podocytes from diabetic nephropathy via downregulation of VEGF/PDK4 axis
  Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li
  Journal of Bioenergetics and Biomembranes.2022; 54(1): 17.     CrossRef
• Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation
  Chen Bai, Yisi Liu, Yichen Zhao, Qing Ye, Cheng Zhao, Yang Liu, Jiangang Wang
  Journal of Cardiovascular Translational Research.2022; 15(6): 1393.     CrossRef
• The impact of different feeds on DNA methylation, glycolysis/gluconeogenesis signaling pathway, and gene expression of sheep muscle
  Feng Song, Zaccheaus Pazamilala Akonyani, Ying Li, Deqiqige Su, Lantuya Wu, Yue Pang, Sile Hu, Dubala Wu, Chun Li, Ding Yang, Jianghong Wu
  PeerJ.2022; 10: e13455.     CrossRef
• Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1‐13C]‐l‐lactate
  Jun Chen, Edward P. Hackett, Zoltan Kovacs, Craig R. Malloy, Jae Mo Park
  Magnetic Resonance in Medicine.2021; 85(3): 1175.     CrossRef
• Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
  Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
  Journal of Diabetes Investigation.2021; 12(1): 21.     CrossRef
• Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
  Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Gokhan Zengin, Nicoleta Negrut, Delia Carmen Nistor-Cseppento, Flavia Maria Pavel, Raluca Anca Corb Aron, Simona Bungau
  International Journal of Molecular Sciences.2021; 22(6): 3179.     CrossRef
• Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
  Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li
  Bioscience Reports.2021;[Epub]     CrossRef
• PDK2: An Underappreciated Regulator of Liver Metabolism
  Benjamin L. Woolbright, Robert A. Harris
  Livers.2021; 1(2): 82.     CrossRef
• Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
  Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
  Experimental & Molecular Medicine.2021; 53(9): 1390.     CrossRef
• Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells
  Ling Jin, Minkyoung Cho, Bo-Sung Kim, Jung Ho Han, Sungmi Park, In-Kyu Lee, Dongryeol Ryu, Jae Ho Kim, Sung-Jin Bae, Ki-Tae Ha
  BMB Reports.2021; 54(11): 563.     CrossRef
• Aberrant PDK4 Promoter Methylation Preceding Hyperglycemia in a Mouse Model
  Sulistyo Emantoko Dwi Putra, Stephanie Singajaya, Ferensia Thesman, Dicky Andhika Pranoto, Ricky Sanjaya, Yoanes Maria Vianney, Ida Bagus Made Artadana
  Applied Biochemistry and Biotechnology.2020; 190(3): 1023.     CrossRef
• Plasma Lipid Profile and Cardiac Risk Markers in Diabetic Nephropathy
  Nagendra Subba Rammaiah, Praveenkumar Deverbhavi, Kashinath Rattihalli Thirumala
  Journal of Evolution of Medical and Dental Sciences.2020; 9(8): 516.     CrossRef
• The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis
  Khalia R. Primer, Peter J. Psaltis, Joanne T.M. Tan, Christina A. Bursill
  International Journal of Molecular Sciences.2020; 21(10): 3633.     CrossRef
• The lncRNA ENST00000608794 acts as a competing endogenous RNA to regulate PDK4 expression by sponging miR-15b-5p in dexamethasone induced steatosis
  Fengqiong Liu, Qing Chen, Fa Chen, Jing Wang, Ruijie Gong, Baochang He
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(10): 1449.     CrossRef
• The Changing Landscape of Pharmacotherapy for Diabetes Mellitus: A Review of Cardiovascular Outcomes
  Linda Wu, Jenny E. Gunton
  International Journal of Molecular Sciences.2019; 20(23): 5853.     CrossRef
• Emerging role of the orphan nuclear receptor estrogen-related receptor gamma in liver metabolic diseases
  Don-Kyu Kim, Hueng-Sik Choi
  Liver Research.2019; 3(2): 99.     CrossRef
• Characterization ofin vitroandin vivometabolism of leelamine using liquid chromatography-tandem mass spectrometry
  Riya Shrestha, Jung Jae Jo, DooHyun Lee, Taeho Lee, Sangkyu Lee
  Xenobiotica.2019; 49(5): 577.     CrossRef
• Proteomics of Rat Lungs Infected by Cryptococcus gattii Reveals a Potential Warburg-like Effect
  Rafael L. Rosa, Markus Berger, Lucélia Santi, David Driemeier, Paula Barros Terraciano, Alexandre R. Campos, Jorge A. Guimarães, Marilene H. Vainstein, John R. Yates, Walter O. Beys-da-Silva
  Journal of Proteome Research.2019; 18(11): 3885.     CrossRef
• Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease
  Waqar Ahmad
  Experimental Brain Research.2018; 236(11): 2857.     CrossRef
• Peroxisome proliferator-activated receptor β/δ does not regulate glucose uptake and lactose synthesis in bovine mammary epithelial cells cultivated in vitro
  Jayant Lohakare, Johan S Osorio, Massimo Bionaz
  Journal of Dairy Research.2018; 85(3): 295.     CrossRef
• Protective potential of Averrhoa bilimbi fruits in ameliorating the hepatic key enzymes in streptozotocin-induced diabetic rats
  Surya B Kurup, Mini S
  Biomedicine & Pharmacotherapy.2017; 85: 725.     CrossRef
• Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
  Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
  Kidney International.2017; 91(4): 880.     CrossRef
• PDK4 Deficiency Induces Intrinsic Apoptosis in Response to Starvation in Fibroblasts from Doberman Pinschers with Dilated Cardiomyopathy
  Kathryn Taggart, Amara Estrada, Patrick Thompson, Francisco Lourenco, Sara Kirmani, Silveli Suzuki-Hatano, Christina A. Pacak
  BioResearch Open Access.2017; 6(1): 182.     CrossRef
• High-salt intake negatively regulates fat deposition in mouse
  Huanxian Cui, Shuyan Yang, Maiqing Zheng, Ranran Liu, Guiping Zhao, Jie Wen
  Scientific Reports.2017;[Epub]     CrossRef
• The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus
  Jasmine Plows, Florence Budin, Rebecka Andersson, Valerie Mills, Katherine Mace, Sandra Davidge, Mark Vickers, Philip Baker, Irma Silva-Zolezzi, Joanna Stanley
  Nutrients.2017; 9(2): 141.     CrossRef
• Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis
  John A Burns, Huanjia Zhang, Elizabeth Hill, Eunsoo Kim, Ryan Kerney
  eLife.2017;[Epub]     CrossRef
• Equine performance genes and the future of doping in horseracing
  Tessa Wilkin, Anna Baoutina, Natasha Hamilton
  Drug Testing and Analysis.2017; 9(9): 1456.     CrossRef
• Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model
  Tao WANG, Hong-Guo SUN, Yong-Li HUA, Peng-Ling LI, Yan-Ming WEI
  Chinese Journal of Natural Medicines.2016; 14(3): 210.     CrossRef
• MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
  Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
  PLOS Genetics.2016; 12(10): e1006308.     CrossRef
• Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats
  Subramani Srinivasan, Udaiyar Muruganathan
  Chemico-Biological Interactions.2016; 250: 38.     CrossRef
• Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
  Hana Park, Nam Ho Jeoung
  Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
• Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion
  Kripa Raman, Stefanie Aeschbacher, Matthias Bossard, Thomas Hochgruber, Andreas J. Zimmermann, Beat A. Kaufmann, Katrin Pumpol, Peter Rickenbacker, Guillaume Paré, David Conen, Alena Talkachova
  PLOS ONE.2016; 11(6): e0157550.     CrossRef
• Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver
  Poonamjot Deol, Jane R. Evans, Joseph Dhahbi, Karthikeyani Chellappa, Diana S. Han, Stephen Spindler, Frances M. Sladek, Jonathan Peterson
  PLOS ONE.2015; 10(7): e0132672.     CrossRef
• Type 2 diabetes mellitus
  Ralph A. DeFronzo, Ele Ferrannini, Leif Groop, Robert R. Henry, William H. Herman, Jens Juul Holst, Frank B. Hu, C. Ronald Kahn, Itamar Raz, Gerald I. Shulman, Donald C. Simonson, Marcia A. Testa, Ram Weiss
  Nature Reviews Disease Primers.2015;[Epub]     CrossRef
• Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
  Nam Ho Jeoung
  Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
• Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: Functions of glucose and lipid metabolism in the feed intake of chickens
  Xin-Ling Fang, Xiao-Tong Zhu, Sheng-Feng Chen, Zhi-Qi Zhang, Qing-Jie Zeng, Lin Deng, Jian-Long Peng, Jian-Jian Yu, Li-Na Wang, Song-Bo Wang, Ping Gao, Qing-Yan Jiang, Gang Shu
  Poultry Science.2014; 93(11): 2841.     CrossRef
• The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
  Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
  Nutrition & Metabolism.2014;[Epub]     CrossRef
• Proteome-Based Systems Biology Analysis of the Diabetic Mouse Aorta Reveals Major Changes in Fatty Acid Biosynthesis as Potential Hallmark in Diabetes Mellitus–Associated Vascular Disease
  Holger Husi, Tom Van Agtmael, William Mullen, Ferdinand H. Bahlmann, Joost P. Schanstra, Antonia Vlahou, Christian Delles, Paul Perco, Harald Mischak
  Circulation: Cardiovascular Genetics.2014; 7(2): 161.     CrossRef
• Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice
  Sasmita Tripathy, Kelli A. Lytle, Robert D. Stevens, James R. Bain, Christopher B. Newgard, Andrew S. Greenberg, Li-Shin Huang, Donald B. Jump
  Journal of Lipid Research.2014; 55(7): 1448.     CrossRef
• Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum
  Elaine M. Richards, Charles E. Wood, Maria Belen Rabaglino, Andrew Antolic, Maureen Keller-Wood
  Physiological Genomics.2014; 46(15): 547.     CrossRef
• Novel Agents for the Treatment of Type 2 Diabetes
  Ralph A. DeFronzo, Curtis L. Triplitt, Muhammad Abdul-Ghani, Eugenio Cersosimo
  Diabetes Spectrum.2014; 27(2): 100.     CrossRef
• Serotonin (5-HT) Affects Expression of Liver Metabolic Enzymes and Mammary Gland Glucose Transporters during the Transition from Pregnancy to Lactation
  Jimena Laporta, Tonia L. Peters, Kathryn E. Merriman, Chad M. Vezina, Laura L. Hernandez, Julie A. Chowen
  PLoS ONE.2013; 8(2): e57847.     CrossRef
• Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats
  Deon B. Williams, Zhongxiao Wan, Bruce C. Frier, Rhonda C. Bell, Catherine J. Field, David C. Wright
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2012; 302(1): R49.     CrossRef
• Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome
  Seong-Su Moon, Jung-Eun Lee, Young-Sil Lee, Su-Won Kim, Nam Ho Jeoung, In-Kyu Lee, Jung-Guk Kim
  Diabetes Research and Clinical Practice.2012; 95(2): 230.     CrossRef
• Sex-dependent differences in rat hepatic lipid accumulation and insulin sensitivity in response to diet-induced obesity
  Antònia Nadal-Casellas, Ana Maria Proenza, Isabel Lladó, Magdalena Gianotti
  Biochemistry and Cell Biology.2012; 90(2): 164.     CrossRef
• Prednisolone-Induced Changes in Gene-Expression Profiles in Healthy Volunteers
  Erik JM Toonen, Wilco WM Fleuren, Ulla Nässander, Marie-José C van Lierop, Susanne Bauerschmidt, Wim HA Dokter, Wynand Alkema
  Pharmacogenomics.2011; 12(7): 985.     CrossRef